                         SEQUENCE LISTING

<110>  Albert Einstein College of Medicine of Yeshiva University
       Industrial Research Limited
 
<120>  METHODS, ASSAYS AND COMPOUNDS FOR TREATING BACTERIAL INFECTIONS 
       BY INHIBITING METHYLTHIOINOSINE PHOSPHORYLASE

<130>  96700/1776

<150>  US 61/458,660
<151>  2010-11-29

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  272
<212>  PRT
<213>  Escherichia coli

<400>  1

Phe Ser His Asn Pro Leu Phe Cys Ile Asp Ile Ile Lys Thr Tyr Lys 
1               5                   10                  15      


Pro Asp Phe Thr Pro Arg Val Ala Phe Ile Leu Gly Ser Gly Leu Gly 
            20                  25                  30          


Ala Leu Ala Asp Gln Ile Glu Asn Ala Val Ala Ile Ser Tyr Glu Lys 
        35                  40                  45              


Leu Pro Gly Phe Pro Val Ser Thr Val His Gly His Ala Gly Glu Leu 
    50                  55                  60                  


Val Leu Gly His Leu Gln Gly Val Pro Val Val Cys Met Lys Gly Arg 
65                  70                  75                  80  


Gly His Phe Tyr Glu Gly Arg Gly Met Thr Ile Met Thr Asp Ala Ile 
                85                  90                  95      


Arg Thr Phe Lys Leu Leu Gly Cys Glu Leu Leu Phe Cys Thr Asn Ala 
            100                 105                 110         


Ala Gly Ser Leu Arg Pro Glu Val Gly Ala Gly Ser Leu Val Ala Leu 
        115                 120                 125             


Lys Asp His Ile Asn Thr Met Pro Gly Thr Pro Met Val Gly Leu Asn 
    130                 135                 140                 


Asp Asp Arg Phe Gly Glu Arg Phe Phe Ser Leu Ala Asn Ala Tyr Asp 
145                 150                 155                 160 


Ala Glu Tyr Arg Ala Leu Leu Gln Lys Val Ala Lys Glu Glu Gly Phe 
                165                 170                 175     


Pro Leu Thr Glu Gly Val Phe Val Ser Tyr Pro Gly Pro Asn Phe Glu 
            180                 185                 190         


Thr Ala Ala Glu Ile Arg Met Met Gln Ile Ile Gly Gly Asp Val Val 
        195                 200                 205             


Gly Met Ser Val Val Pro Glu Val Ile Ser Ala Arg His Cys Asp Leu 
    210                 215                 220                 


Lys Val Val Ala Val Ser Ala Ile Thr Asn Met Ala Glu Gly Leu Ser 
225                 230                 235                 240 


Asp Val Lys Leu Ser His Ala Gln Thr Leu Ala Ala Ala Glu Leu Ser 
                245                 250                 255     


Lys Gln Asn Phe Ile Asn Leu Ile Cys Gly Phe Leu Arg Lys Ile Ala 
            260                 265                 270         


<210>  2
<211>  260
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  2

Asp Glu Leu Ala Arg Arg Ala Ala Gln Val Ile Ala Asp Arg Thr Gly 
1               5                   10                  15      


Ile Gly Glu His Asp Val Ala Val Val Leu Gly Ser Gly Trp Leu Pro 
            20                  25                  30          


Ala Val Ala Ala Leu Gly Ser Pro Thr Thr Val Leu Pro Gln Ala Glu 
        35                  40                  45              


Leu Pro Gly Phe Val Pro Pro Thr Ala Ala Gly His Ala Gly Glu Leu 
    50                  55                  60                  


Leu Ser Val Pro Ile Gly Ala His Arg Val Leu Val Leu Ala Gly Arg 
65                  70                  75                  80  


Ile His Ala Tyr Glu Gly His Asp Leu Arg Tyr Val Val His Pro Val 
                85                  90                  95      


Arg Ala Ala Arg Ala Ala Gly Ala Gln Ile Met Val Leu Thr Asn Ala 
            100                 105                 110         


Ala Gly Gly Leu Arg Ala Asp Leu Gln Val Gly Gln Pro Val Leu Ile 
        115                 120                 125             


Ser Asp His Leu Asn Leu Thr Ala Arg Ser Pro Leu Val Gly Gly Glu 
    130                 135                 140                 


Phe Val Asp Leu Thr Asp Ala Tyr Ser Pro Arg Leu Arg Glu Leu Ala 
145                 150                 155                 160 


Arg Gln Ser Asp Pro Gln Leu Ala Glu Gly Val Tyr Ala Gly Leu Pro 
                165                 170                 175     


Gly Pro His Tyr Glu Thr Pro Ala Glu Ile Arg Met Leu Gln Thr Leu 
            180                 185                 190         


Gly Ala Asp Leu Val Gly Met Ser Thr Val His Glu Thr Ile Ala Ala 
        195                 200                 205             


Arg Ala Ala Gly Ala Glu Val Leu Gly Val Ser Leu Val Thr Asn Leu 
    210                 215                 220                 


Ala Ala Gly Ile Thr Gly Glu Pro Leu Ser His Ala Glu Val Leu Ala 
225                 230                 235                 240 


Ala Gly Ala Ala Ser Ala Thr Arg Met Gly Ala Leu Leu Ala Asp Val 
                245                 250                 255     


Ile Ala Arg Phe 
            260 


<210>  3
<211>  280
<212>  PRT
<213>  Grouper iridoviurs

<400>  3

Asp Tyr Asp Leu Ala Lys Glu Thr Ala Ala Trp Leu Asn Lys Gln Leu 
1               5                   10                  15      


Gln Ile Arg Pro Val Leu Gly Ile Val Cys Gly Ser Gly Leu Gly Lys 
            20                  25                  30          


Ile Gly Asp Ser Leu Glu Thr Ser Ile Thr Val Ala Tyr Ser Asp Ile 
        35                  40                  45              


Pro Asn Phe Pro Val Gly Ser Val Lys Gly His Ala Gly Ser Leu Ile 
    50                  55                  60                  


Phe Gly Ser Val Asn Gly Val Ser Cys Val Cys Met Lys Gly Arg Phe 
65                  70                  75                  80  


His Leu Tyr Glu Gly His Thr Ala Ala Arg Ala Thr Phe Pro Met Arg 
                85                  90                  95      


Val Phe Lys Ala Leu Gly Val Lys Ile Val Val Leu Thr Asn Ala Ala 
            100                 105                 110         


Gly Gly Leu Asn Pro Ser Tyr Arg Pro Gly Asp Phe Met Val Val Arg 
        115                 120                 125             


Asp His Ile Asn Leu Pro Gly Leu Ala Gly Ala Asn Pro Leu Thr Gly 
    130                 135                 140                 


Pro Asn Asp Asp Thr Glu Gly Glu Arg Phe Pro Ser Met Thr Ser Val 
145                 150                 155                 160 


Tyr Asp Lys Thr Leu Arg Lys Tyr Ala Ile Ser Ala Ala Arg Glu Leu 
                165                 170                 175     


Gly Met Ser Tyr Ala Thr His Glu Gly Val Tyr Cys Cys Val Asn Gly 
            180                 185                 190         


Pro Ser Phe Glu Thr Pro Ala Glu Cys Lys Ile Leu Arg Leu Met Gly 
        195                 200                 205             


Ser Asp Ala Val Gly Met Ser Thr Ala Pro Glu Thr Ile Val Ala Lys 
    210                 215                 220                 


His Gly Gly Met Arg Cys Leu Ala Val Ser Leu Ile Ser Asn Val Ile 
225                 230                 235                 240 


Ala Ser Asn Cys Glu Thr Pro Ala Glu Pro Thr His Glu Glu Val Leu 
                245                 250                 255     


Arg Ala Gly Glu Glu Ala Ser Ala Arg Met Thr Ala Leu Val Lys Leu 
            260                 265                 270         


Val Ile Glu Lys Ile Arg Gly Glu 
        275                 280 


<210>  4
<211>  281
<212>  PRT
<213>  Anopheles gambia

<400>  4

Tyr Thr Tyr Asp Thr Leu Gln Glu Ile Ala Thr Tyr Leu Leu Glu Arg 
1               5                   10                  15      


Thr Glu Leu Arg Pro Lys Val Gly Ile Ile Cys Gly Ser Gly Leu Gly 
            20                  25                  30          


Thr Leu Ala Glu Gln Leu Thr Asp Val Asp Ser Phe Asp Tyr Glu Thr 
        35                  40                  45              


Ile Pro His Phe Pro Val Ser Thr Val Ala Gly His Val Gly Arg Leu 
    50                  55                  60                  


Val Phe Gly Tyr Leu Ala Gly Val Pro Val Met Cys Met Gln Gly Arg 
65                  70                  75                  80  


Phe His His Tyr Glu Gly Tyr Pro Leu Ala Lys Cys Ala Met Pro Val 
                85                  90                  95      


Arg Val Met His Leu Ile Gly Cys Thr His Leu Ile Ala Thr Asn Ala 
            100                 105                 110         


Ala Gly Gly Ala Asn Pro Lys Tyr Arg Val Gly Asp Ile Met Leu Ile 
        115                 120                 125             


Lys Asp His Ile Asn Leu Met Gly Phe Ala Gly Asn Asn Pro Leu Gln 
    130                 135                 140                 


Gly Pro Asn Asp Glu Arg Phe Gly Pro Arg Phe Gly Met Ala Asn Thr 
145                 150                 155                 160 


Tyr Asp Pro Lys Leu Asn Gln Gln Ala Lys Val Ile Ala Arg Gln Ile 
                165                 170                 175     


Gly Ile Glu Asn Glu Leu Arg Glu Gly Val Tyr Thr Cys Leu Gly Gly 
            180                 185                 190         


Pro Asn Phe Glu Thr Val Ala Glu Val Lys Met Leu Ser Met Leu Gly 
        195                 200                 205             


Val Asp Ala Ile Gly Met Ser Thr Val His Glu Ile Ile Thr Ala Arg 
    210                 215                 220                 


His Cys Gly Met Thr Cys Phe Ala Phe Ser Leu Ile Thr Asn Met Cys 
225                 230                 235                 240 


Thr Met Ser Tyr Glu Glu Glu Glu Glu His Cys His Asp Ser Ile Val 
                245                 250                 255     


Gly Val Gly Lys Asn Arg Glu Lys Thr Leu Gly Glu Phe Val Ser Arg 
            260                 265                 270         


Ile Val Lys His Ile His Tyr Glu Ala 
        275                 280     


<210>  5
<211>  265
<212>  PRT
<213>  Thermotoga maritime

<400>  5

Met Met Lys Lys Ile Glu Glu Ala Arg Thr Phe Ile Ser Glu Arg Thr 
1               5                   10                  15      


Asn Leu Ser Pro Asp Ile Leu Ile Ile Leu Gly Ser Gly Phe Gly Pro 
            20                  25                  30          


Phe Ile Glu Lys Val Glu Asp Pro Val Ile Ile Asp Tyr Lys Asp Ile 
        35                  40                  45              


Pro His Phe Pro Gln Pro Thr Val Glu Gly His Ser Gly Lys Leu Val 
    50                  55                  60                  


Phe Gly Arg Ile Ser Asp Lys Pro Val Met Ile Met Ala Gly Arg Phe 
65                  70                  75                  80  


His Leu Tyr Glu Gly His Asp Pro Ala Thr Val Ala Phe Pro Val Tyr 
                85                  90                  95      


Leu Ala Lys Tyr Val Gly Val Lys Gly Val Val Val Thr Asn Ala Ala 
            100                 105                 110         


Gly Ala Ile Asn Pro Glu Phe Lys Pro Gly Glu Ile Ile Leu Val Arg 
        115                 120                 125             


Asp Ile Ile Asn Phe Met Phe Arg Asn Pro Leu Arg Gly Pro Asn Asp 
    130                 135                 140                 


Glu Lys Ile Gly Pro Arg Phe Pro Asp Met Ser Ser Val Val Asp Pro 
145                 150                 155                 160 


Glu Trp Ala Arg Lys Ile Gln Glu Arg Leu Ser Leu Lys Glu Gly Val 
                165                 170                 175     


Tyr Ile Gly Val Leu Gly Pro Ser Tyr Glu Thr Pro Ala Glu Ile Arg 
            180                 185                 190         


Val Phe Glu Lys Leu Gly Ala Asp Leu Val Gly Met Ser Thr Val Pro 
        195                 200                 205             


Glu Val Ile Ala Ala Lys His Cys Gly Leu Lys Val Val Val Phe Ser 
    210                 215                 220                 


Cys Val Thr Asn Met Ala Ala Gly Ile Thr His Gly Arg Leu Ser His 
225                 230                 235                 240 


Glu Glu Val Val Arg Thr Thr Lys Met Ala Gln Gly Lys Ile Glu Lys 
                245                 250                 255     


Ala Leu Thr Thr Ala Val Glu Val Phe 
            260                 265 


<210>  6
<211>  278
<212>  PRT
<213>  Bos taurus

<400>  6

Tyr Thr Tyr Glu Asp Tyr Gln Asp Thr Ala Lys Trp Leu Leu Ser His 
1               5                   10                  15      


Thr Glu Gln Arg Pro Gln Val Ala Val Ile Cys Gly Ser Gly Leu Gly 
            20                  25                  30          


Gly Leu Val Asn Lys Leu Thr Gln Ala Gln Thr Phe Asp Tyr Ser Glu 
        35                  40                  45              


Ile Pro Asn Phe Pro Glu Ser Thr Val Pro Gly His Ala Gly Arg Leu 
    50                  55                  60                  


Val Phe Gly Ile Leu Asn Gly Arg Ala Cys Val Met Met Gln Gly Arg 
65                  70                  75                  80  


Phe His Met Tyr Glu Gly Tyr Pro Phe Trp Lys Val Thr Phe Pro Val 
                85                  90                  95      


Arg Val Phe Arg Leu Leu Gly Val Glu Thr Leu Val Val Thr Asn Ala 
            100                 105                 110         


Ala Gly Gly Leu Asn Pro Asn Phe Glu Val Gly Asp Ile Met Leu Ile 
        115                 120                 125             


Arg Asp His Ile Asn Leu Pro Gly Phe Ser Gly Glu Asn Pro Leu Arg 
    130                 135                 140                 


Gly Pro Asn Glu Glu Arg Phe Gly Val Arg Phe Pro Ala Met Ser Asp 
145                 150                 155                 160 


Ala Tyr Asp Arg Asp Met Arg Gln Lys Ala His Ser Thr Trp Lys Gln 
                165                 170                 175     


Met Gly Glu Gln Arg Glu Leu Gln Glu Gly Thr Tyr Val Met Leu Gly 
            180                 185                 190         


Gly Pro Asn Phe Glu Thr Val Ala Glu Cys Arg Leu Leu Arg Asn Leu 
        195                 200                 205             


Gly Ala Asp Ala Val Gly Met Ser Thr Val Pro Glu Val Ile Val Ala 
    210                 215                 220                 


Arg His Cys Gly Leu Arg Val Phe Gly Phe Ser Leu Ile Thr Asn Lys 
225                 230                 235                 240 


Val Ile Met Asp Thr Glu Ser Gln Gly Lys Ala Asn His Glu Glu Val 
                245                 250                 255     


Leu Glu Ala Gly Lys Gln Ala Ala Gln Lys Leu Glu Gln Phe Val Ser 
            260                 265                 270         


Leu Leu Met Ala Ser Ile 
        275             


<210>  7
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  7

Tyr Thr Tyr Glu Asp Tyr Lys Asn Thr Ala Glu Trp Leu Leu Ser His 
1               5                   10                  15      


Thr Lys His Arg Pro Gln Val Ala Ile Ile Cys Gly Ser Gly Leu Gly 
            20                  25                  30          


Gly Leu Thr Asp Lys Leu Thr Gln Ala Gln Ile Phe Asp Tyr Ser Glu 
        35                  40                  45              


Ile Pro Asn Phe Pro Arg Ser Thr Val Pro Gly His Ala Gly Arg Leu 
    50                  55                  60                  


Val Phe Gly Phe Leu Asn Gly Arg Ala Cys Val Met Met Gln Gly Arg 
65                  70                  75                  80  


Phe His Met Tyr Glu Gly Tyr Pro Leu Trp Lys Val Thr Phe Pro Val 
                85                  90                  95      


Arg Val Phe His Leu Leu Gly Val Asp Thr Leu Val Val Thr Asn Ala 
            100                 105                 110         


Ala Gly Gly Leu Asn Pro Lys Phe Glu Val Gly Asp Ile Met Leu Ile 
        115                 120                 125             


Arg Asp His Ile Asn Leu Pro Gly Phe Ser Gly Gln Asn Pro Leu Arg 
    130                 135                 140                 


Gly Pro Asn Asp Glu Arg Phe Gly Asp Arg Phe Pro Ala Met Ser Asp 
145                 150                 155                 160 


Ala Tyr Asp Arg Thr Met Arg Gln Arg Ala Leu Ser Thr Trp Lys Gln 
                165                 170                 175     


Met Gly Glu Gln Arg Glu Leu Gln Glu Gly Thr Tyr Val Met Val Ala 
            180                 185                 190         


Gly Pro Ser Phe Glu Thr Val Ala Glu Cys Arg Val Leu Gln Lys Leu 
        195                 200                 205             


Gly Ala Asp Ala Val Gly Met Ser Thr Val Pro Glu Val Ile Val Ala 
    210                 215                 220                 


Arg His Cys Gly Leu Arg Val Phe Gly Phe Ser Leu Ile Thr Asn Lys 
225                 230                 235                 240 


Val Ile Met Asp Tyr Glu Ser Leu Glu Lys Ala Asn His Glu Glu Val 
                245                 250                 255     


Leu Ala Ala Gly Lys Gln Ala Ala Gln Lys Leu Glu Gln Phe Val Ser 
            260                 265                 270         


Ile Leu Met Ala Ser Ile 
        275             


<210>  8
<211>  242
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  8

Val Tyr Ala Ile Ile Gly Gly Thr Gly Leu Thr Gln Leu Glu Gly Leu 
1               5                   10                  15      


Thr Leu Ser Glu Ser Leu Pro Ile Glu Thr Pro Tyr Gly Ala Pro Ser 
            20                  25                  30          


Ala Pro Leu Gln Arg Gly Arg Tyr Ala Gly Arg Glu Val Leu Phe Leu 
        35                  40                  45              


Ala Arg His Gly His Pro His Arg Phe Pro Pro His Gln Val Asn Tyr 
    50                  55                  60                  


Arg Ala Asn Leu Trp Ala Leu Lys Gln Ala Gly Ala Glu Ala Val Ile 
65                  70                  75                  80  


Ala Val Asn Ala Val Gly Gly Ile His Ala Ala Met Gly Thr Gly His 
                85                  90                  95      


Leu Cys Val Pro His Gln Leu Ile Asp Tyr Thr Ser Gly Arg Glu His 
            100                 105                 110         


Thr Tyr Phe Ala Gly Asp Ile Glu His Val Thr His Ile Asp Phe Ser 
        115                 120                 125             


His Pro Tyr Asp Glu Pro Leu Arg Gln Arg Leu Ile Glu Ala Leu Arg 
    130                 135                 140                 


Ala Leu Gly Leu Ala His Ser Ser His Gly Val Tyr Ala Cys Thr Gln 
145                 150                 155                 160 


Gly Pro Arg Leu Glu Thr Val Ala Glu Ile Ala Arg Leu Glu Arg Asp 
                165                 170                 175     


Gly Asn Asp Ile Val Gly Met Thr Gly Met Pro Glu Ala Ala Leu Ala 
            180                 185                 190         


Arg Glu Leu Asp Leu Pro Tyr Ala Cys Leu Ala Leu Val Val Asn Pro 
        195                 200                 205             


Ala Ala Gly Lys Ser Ala Gly Ile Ile Thr Met Ala Glu Ile Glu Gln 
    210                 215                 220                 


Ala Leu His Asp Gly Ile Gly Lys Val Arg Glu Val Leu Ala Arg Val 
225                 230                 235                 240 


Leu Ala 
        


<210>  9
<211>  246
<212>  PRT
<213>  Sulfolobus tokodaii

<400>  9

Glu Lys Ala Ser Ile Gly Ile Ile Gly Gly Ser Gly Leu Tyr Asp Pro 
1               5                   10                  15      


Gln Ile Leu Thr Asn Val Lys Glu Ile Lys Val Tyr Thr Pro Tyr Gly 
            20                  25                  30          


Glu Pro Ser Asp Asn Ile Ile Leu Gly Glu Leu Glu Gly Arg Lys Val 
        35                  40                  45              


Ala Phe Leu Pro Arg His Gly Arg Gly His Arg Ile Pro Pro His Lys 
    50                  55                  60                  


Ile Asn Tyr Arg Ala Asn Ile Trp Ala Leu Lys Ser Leu Gly Val Lys 
65                  70                  75                  80  


Trp Val Ile Ala Val Ser Ala Val Gly Ser Leu Arg Leu Asp Tyr Lys 
                85                  90                  95      


Pro Gly Asp Phe Val Val Pro Asn Gln Phe Ile Asp Met Thr Lys Gly 
            100                 105                 110         


Arg Thr Tyr Thr Phe Phe Asp Gly Pro Thr Val Ala His Val Ser Met 
        115                 120                 125             


Ala Asp Pro Phe Cys Glu His Leu Arg Ser Ile Ile Leu Asp Ser Ala 
    130                 135                 140                 


Lys Asp Leu Gly Ile Thr Thr His Asp Lys Gly Thr Tyr Ile Cys Ile 
145                 150                 155                 160 


Glu Gly Pro Arg Phe Ser Thr Arg Ala Glu Ser Ile Val Trp Lys Glu 
                165                 170                 175     


Val Phe Lys Ala Asp Ile Ile Gly Met Thr Leu Val Pro Glu Val Asn 
            180                 185                 190         


Leu Ala Cys Glu Ala Glu Met Cys Tyr Ser Val Ile Gly Met Val Thr 
        195                 200                 205             


Asp Tyr Asp Val Phe Ala Asp Ile Pro Val Thr Ala Glu Glu Val Thr 
    210                 215                 220                 


Lys Val Met Ala Glu Asn Thr Ala Lys Val Lys Lys Leu Leu Tyr Glu 
225                 230                 235                 240 


Val Ile Arg Arg Leu Pro 
                245     


<210>  10
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  10

Lys Ile Gly Ile Ile Gly Gly Thr Gly Leu Asp Asp Pro Glu Ile Leu 
1               5                   10                  15      


Glu Gly Arg Thr Glu Lys Tyr Val Asp Thr Pro Phe Gly Lys Pro Ser 
            20                  25                  30          


Asp Ala Leu Ile Leu Gly Lys Ile Lys Asn Val Asp Cys Val Leu Leu 
        35                  40                  45              


Ala Arg His Gly Arg Gln His Thr Ile Met Pro Ser Lys Val Asn Tyr 
    50                  55                  60                  


Gln Ala Asn Ile Trp Ala Leu Lys Glu Glu Gly Cys Thr His Val Ile 
65                  70                  75                  80  


Val Thr Thr Ala Cys Gly Ser Leu Arg Glu Glu Ile Gln Pro Gly Asp 
                85                  90                  95      


Ile Val Ile Ile Asp Gln Phe Ile Asp Arg Thr Thr Met Arg Pro Gln 
            100                 105                 110         


Ser Phe Tyr Asp Gly Ser His Ser Cys Ala Arg Gly Val Cys His Ile 
        115                 120                 125             


Pro Met Ala Glu Pro Phe Cys Pro Lys Thr Arg Glu Val Leu Ile Glu 
    130                 135                 140                 


Thr Ala Lys Lys Leu Gly Leu Arg Cys His Ser Lys Gly Thr Met Val 
145                 150                 155                 160 


Thr Ile Glu Gly Pro Arg Phe Ser Ser Arg Ala Glu Ser Phe Met Phe 
                165                 170                 175     


Arg Thr Trp Gly Ala Asp Val Ile Asn Met Thr Thr Val Pro Glu Val 
            180                 185                 190         


Val Leu Ala Lys Glu Ala Gly Ile Cys Tyr Ala Ser Ile Ala Met Ala 
        195                 200                 205             


Thr Asp Tyr Asp Cys Trp Lys Glu His Glu Glu Ala Val Ser Val Asp 
    210                 215                 220                 


Arg Val Leu Lys Thr Leu Lys Glu Asn Ala Asn Lys Ala Lys Ser Leu 
225                 230                 235                 240 


Leu Leu Thr Thr Ile Pro Gln Ile Gly Ser Thr Glu 
                245                 250         


<210>  11
<211>  256
<212>  PRT
<213>  Aeropyrum pernix

<400>  11

Glu Ile Thr Arg Pro Pro Gly Val Arg Ala His Val Gly Val Ile Gly 
1               5                   10                  15      


Gly Ser Gly Leu Tyr Asp Pro Gly Ile Val Glu Asn Pro Val Glu Val 
            20                  25                  30          


Lys Val Ser Thr Pro Tyr Gly Asn Pro Ser Asp Phe Ile Val Val Gly 
        35                  40                  45              


Asp Val Ala Gly Val Lys Val Ala Phe Leu Pro Arg His Gly Arg Gly 
    50                  55                  60                  


His Arg Ile Pro Pro His Ala Ile Asn Tyr Arg Ala Asn Ile Trp Ala 
65                  70                  75                  80  


Leu Lys Ala Leu Gly Val Lys Trp Val Ile Ser Val Ser Ala Val Gly 
                85                  90                  95      


Ser Leu Arg Glu Asp Tyr Arg Pro Gly Asp Phe Val Val Pro Asp Gln 
            100                 105                 110         


Phe Ile Asp Met Thr Lys Asn Arg Arg His Tyr Thr Phe Tyr Asp Gly 
        115                 120                 125             


Pro Val Thr Val His Val Ser Met Ala Asp Pro Phe Cys Glu Asp Leu 
    130                 135                 140                 


Arg Gln Arg Leu Ile Asp Ser Gly Arg Arg Leu Gly Tyr Thr Val His 
145                 150                 155                 160 


Glu Arg Gly Thr Tyr Val Cys Ile Glu Gly Pro Arg Phe Ser Thr Arg 
                165                 170                 175     


Ala Glu Ser Arg Val Trp Lys Asp Val Phe Lys Ala Asp Ile Ile Gly 
            180                 185                 190         


Met Thr Leu Val Pro Glu Ile Asn Leu Ala Cys Glu Ala Gln Leu Cys 
        195                 200                 205             


Tyr Ala Thr Leu Ala Met Val Thr Asp Tyr Asp Val Trp Ala Asp Arg 
    210                 215                 220                 


Pro Val Thr Ala Glu Glu Val Glu Arg Val Met Ile Ser Asn Val Glu 
225                 230                 235                 240 


Arg Ala Arg Arg Met Leu Tyr Asp Val Ile Pro Lys Leu Ala Gly Glu 
                245                 250                 255     


<210>  12
<211>  253
<212>  PRT
<213>  Sulfolobus solfataricus

<400>  12

Ile Glu Gln Asn Glu Lys Ala Ser Ile Gly Ile Ile Gly Gly Ser Gly 
1               5                   10                  15      


Leu Tyr Asp Pro Gly Ile Phe Ser Glu Ser Lys Glu Ile Lys Val Tyr 
            20                  25                  30          


Thr Pro Tyr Gly Gln Pro Ser Asp Phe Ile Thr Ile Gly Lys Ile Gly 
        35                  40                  45              


Asn Lys Ser Val Ala Phe Leu Pro Arg His Gly Arg Gly His Arg Ile 
    50                  55                  60                  


Pro Pro His Lys Ile Asn Tyr Arg Ala Asn Ile Trp Ala Leu Lys Glu 
65                  70                  75                  80  


Leu Gly Val Arg Trp Val Ile Ser Val Ser Ala Val Gly Ser Leu Arg 
                85                  90                  95      


Met Asp Tyr Lys Leu Gly Asp Phe Val Ile Pro Asp Gln Phe Ile Asp 
            100                 105                 110         


Met Thr Lys Asn Arg Glu Tyr Ser Phe Phe Asp Gly Pro Val Val Ala 
        115                 120                 125             


His Val Ser Met Ala Asp Pro Phe Cys Asn Ser Leu Arg Lys Leu Ala 
    130                 135                 140                 


Ile Glu Thr Ala Lys Glu Leu Asn Ile Lys Thr His Glu Ser Gly Thr 
145                 150                 155                 160 


Tyr Ile Cys Ile Glu Gly Pro Arg Phe Ser Thr Arg Ala Glu Ser Arg 
                165                 170                 175     


Thr Trp Arg Glu Val Tyr Lys Ala Asp Ile Ile Gly Met Thr Leu Val 
            180                 185                 190         


Pro Glu Val Asn Leu Ala Cys Glu Ala Gln Met Cys Tyr Ala Thr Ile 
        195                 200                 205             


Ala Met Val Thr Asp Tyr Asp Val Phe Ala Glu Ile Pro Val Thr Ala 
    210                 215                 220                 


Glu Glu Val Thr Arg Val Met Ala Glu Asn Thr Glu Lys Ala Lys Lys 
225                 230                 235                 240 


Leu Leu Tyr Ala Leu Ile Gln Lys Leu Pro Glu Lys Pro 
                245                 250             


