                              Sequence Listing

<110> GENENTECH, INC. et al.

<120> NOVEL RECEPTOR-LIGAND INTERACTION AND USES THEREOF

<130> P4549R1-WO

<141> 2011-12-01

<150> US 61/419,209
<151> 2010-02-12

<160> 33

<210> 1
<211> 355
<212> PRT
<213> Homo sapiens

<400> 1
 Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala
   1               5                  10                  15

 Leu Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu
                  20                  25                  30

 Tyr Trp Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg
                  35                  40                  45

 Phe Gly Pro Pro Pro Cys Pro Asp Tyr Glu Phe Arg Glu Asn Cys
                  50                  55                  60

 Gly Leu Asn Asp His Gly Asp Phe Val Thr Pro Pro Phe Arg Lys
                  65                  70                  75

 Cys Ser Ser Gly Gln Cys Asn Pro Asp Gly Ala Glu Leu Cys Ser
                  80                  85                  90

 Pro Cys Gly Gly Gly Ala Val Thr Pro Thr Pro Ala Ala Gly Gly
                  95                 100                 105

 Gly Arg Thr Pro Trp Arg Cys Arg Glu Arg Pro Val Pro Ala Lys
                 110                 115                 120

 Gly His Cys Pro Leu Thr Pro Gly Asn Pro Gly Ala Pro Ser Ser
                 125                 130                 135

 Gln Glu Arg Ser Ser Pro Ala Ser Ser Ile Ala Trp Arg Thr Pro
                 140                 145                 150

 Glu Pro Val Pro Gln Gln Ala Trp Pro Asn Phe Leu Pro Leu Val
                 155                 160                 165

 Val Leu Val Leu Leu Leu Thr Leu Ala Val Ile Ala Ile Leu Leu
                 170                 175                 180

 Phe Ile Leu Leu Trp His Leu Cys Trp Pro Lys Glu Lys Ala Asp
                 185                 190                 195

 Pro Tyr Pro Tyr Pro Gly Leu Val Cys Gly Val Pro Asn Thr His
                 200                 205                 210

 Thr Pro Ser Ser Ser His Leu Ser Ser Pro Gly Ala Leu Glu Thr
                 215                 220                 225

 Gly Asp Thr Trp Lys Glu Ala Ser Leu Leu Pro Leu Leu Ser Arg
                 230                 235                 240

 Glu Leu Ser Ser Leu Ala Ser Gln Pro Leu Ser Arg Leu Leu Asp
                 245                 250                 255

 Glu Leu Glu Val Leu Glu Glu Leu Ile Val Leu Leu Asp Pro Glu
                 260                 265                 270

 Pro Gly Pro Gly Gly Gly Met Ala His Gly Thr Thr Arg His Leu
                 275                 280                 285

 Ala Ala Arg Tyr Gly Leu Pro Ala Ala Trp Ser Thr Phe Ala Tyr
                 290                 295                 300

 Ser Leu Arg Pro Ser Arg Ser Pro Leu Arg Ala Leu Ile Glu Met
                 305                 310                 315

 Val Val Ala Arg Glu Pro Ser Ala Ser Leu Gly Gln Leu Gly Thr
                 320                 325                 330

 His Leu Ala Gln Leu Gly Arg Ala Asp Ala Leu Arg Val Leu Ser
                 335                 340                 345

 Lys Leu Gly Ser Ser Gly Val Cys Trp Ala
                 350                 355

<210> 2
<211> 22
<212> PRT
<213> Homo sapiens

<400> 2
 Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala
   1               5                  10                  15

 Leu Ala Pro Pro Pro Glu Ala
                  20        

<210> 3
<211> 345
<212> PRT
<213> Mus musculus

<400> 3
 Met Gly Pro Ser Trp Leu Leu Trp Thr Val Ala Val Ala Val Leu
   1               5                  10                  15

 Leu Leu Thr Arg Ala Ala Ser Met Glu Ala Ser Ser Phe Cys Gly
                  20                  25                  30

 His Leu Glu Tyr Trp Asn Ser Asp Lys Arg Cys Cys Ser Arg Cys
                  35                  40                  45

 Leu Gln Arg Phe Gly Pro Pro Ala Cys Pro Asp His Glu Phe Thr
                  50                  55                  60

 Glu Asn Cys Gly Leu Asn Asp Phe Gly Asp Thr Val Ala His Pro
                  65                  70                  75

 Phe Lys Lys Cys Ser Pro Gly Tyr Cys Asn Pro Asn Gly Thr Glu
                  80                  85                  90

 Leu Cys Ser Gln Cys Ser Ser Gly Ala Ala Ala Ala Pro Ala His
                  95                 100                 105

 Val Glu Ser Pro Gly Arg Thr His Lys Gln Cys Arg Lys Lys Pro
                 110                 115                 120

 Val Pro Pro Lys Asp Val Cys Pro Leu Lys Pro Glu Asp Ala Gly
                 125                 130                 135

 Ala Ser Ser Ser Pro Gly Arg Trp Ser Leu Gly Gln Thr Thr Lys
                 140                 145                 150

 Asn Glu Val Ser Ser Arg Pro Gly Phe Val Ser Ala Ser Val Leu
                 155                 160                 165

 Pro Leu Ala Val Leu Pro Leu Leu Leu Val Leu Leu Leu Ile Leu
                 170                 175                 180

 Ala Val Val Leu Leu Ser Leu Phe Lys Arg Lys Val Arg Ser Arg
                 185                 190                 195

 Pro Gly Ser Ser Ser Ala Phe Gly Asp Pro Ser Thr Ser Leu His
                 200                 205                 210

 Tyr Trp Pro Cys Pro Gly Thr Leu Glu Val Leu Glu Ser Arg Asn
                 215                 220                 225

 Arg Gly Lys Ala Asn Leu Leu Gln Leu Ser Ser Trp Glu Leu Gln
                 230                 235                 240

 Gly Leu Ala Ser Gln Pro Leu Ser Leu Leu Leu Asp Glu Leu Glu
                 245                 250                 255

 Val Leu Glu Glu Leu Ile Met Leu Leu Asp Pro Glu Pro Gly Pro
                 260                 265                 270

 Ser Gly Ser Thr Ala Tyr Gly Thr Thr Arg His Leu Ala Ala Arg
                 275                 280                 285

 Tyr Gly Leu Pro Ala Thr Trp Ser Thr Phe Ala Tyr Ser Leu Arg
                 290                 295                 300

 Pro Ser Arg Ser Pro Leu Arg Ala Leu Ile Glu Met Val Val Ala
                 305                 310                 315

 Arg Glu Pro Ser Ala Thr Leu Gly Gln Phe Gly Thr Tyr Leu Ala
                 320                 325                 330

 Gln Leu Gly Arg Thr Asp Ala Leu Gln Val Leu Ser Lys Leu Gly
                 335                 340                 345

<210> 4
<211> 22
<212> PRT
<213> Mus musculus

<400> 4
 Met Gly Pro Ser Trp Leu Leu Trp Thr Val Ala Val Ala Val Leu
   1               5                  10                  15

 Leu Leu Thr Arg Ala Ala Ser
                  20        

<210> 5
<211> 20
<212> PRT
<213> Mus musculus

<400> 5
 Met Gly Pro Ser Trp Leu Leu Trp Thr Val Ala Val Ala Val Leu
   1               5                  10                  15

 Leu Leu Thr Arg Ala
                  20

<210> 6
<211> 110
<212> PRT
<213> Homo sapiens

<400> 6
 Met Ala Pro Arg Gly Cys Ile Val Ala Val Phe Ala Ile Phe Cys
   1               5                  10                  15

 Ile Ser Arg Leu Leu Cys Ser His Gly Ala Pro Val Ala Pro Met
                  20                  25                  30

 Thr Pro Tyr Leu Met Leu Cys Gln Pro His Lys Arg Cys Gly Asp
                  35                  40                  45

 Lys Phe Tyr Asp Pro Leu Gln His Cys Cys Tyr Asp Asp Ala Val
                  50                  55                  60

 Val Pro Leu Ala Arg Thr Gln Thr Cys Gly Asn Cys Thr Phe Arg
                  65                  70                  75

 Val Cys Phe Glu Gln Cys Cys Pro Trp Thr Phe Met Val Lys Leu
                  80                  85                  90

 Ile Asn Gln Asn Cys Asp Ser Ala Arg Thr Ser Asp Asp Arg Leu
                  95                 100                 105

 Cys Arg Ser Val Ser
                 110

<210> 7
<211> 123
<212> PRT
<213> Homo sapiens

<400> 7
 Met Arg Thr Asp Tyr Pro Arg Ser Val Leu Ala Pro Ala Tyr Val
   1               5                  10                  15

 Ser Val Cys Leu Leu Leu Leu Cys Pro Arg Glu Val Ile Ala Pro
                  20                  25                  30

 Ala Gly Ser Glu Pro Trp Leu Cys Gln Pro Ala Pro Arg Cys Gly
                  35                  40                  45

 Asp Lys Ile Tyr Asn Pro Leu Glu Gln Cys Cys Tyr Asn Asp Ala
                  50                  55                  60

 Ile Val Ser Leu Ser Glu Thr Arg Gln Cys Gly Pro Pro Cys Thr
                  65                  70                  75

 Phe Trp Pro Cys Phe Glu Leu Cys Cys Leu Asp Ser Phe Gly Leu
                  80                  85                  90

 Thr Asn Asp Phe Val Val Lys Leu Lys Val Gln Gly Val Asn Ser
                  95                 100                 105

 Gln Cys His Ser Ser Pro Ile Ser Ser Lys Cys Glu Ser Arg Arg
                 110                 115                 120

 Arg Phe Pro
            

<210> 8
<211> 125
<212> PRT
<213> Homo sapiens

<400> 8
 Met Arg Pro Arg Cys Cys Ile Leu Ala Leu Val Cys Trp Ile Thr
   1               5                  10                  15

 Val Phe Leu Leu Gln Cys Ser Lys Gly Thr Thr Asp Ala Pro Val
                  20                  25                  30

 Gly Ser Gly Leu Trp Leu Cys Gln Pro Thr Pro Arg Cys Gly Asn
                  35                  40                  45

 Lys Ile Tyr Asn Pro Ser Glu Gln Cys Cys Tyr Asp Asp Ala Ile
                  50                  55                  60

 Leu Ser Leu Lys Glu Thr Arg Arg Cys Gly Ser Thr Cys Thr Phe
                  65                  70                  75

 Trp Pro Cys Phe Glu Leu Cys Cys Pro Glu Ser Phe Gly Pro Gln
                  80                  85                  90

 Gln Lys Phe Leu Val Lys Leu Arg Val Leu Gly Met Lys Ser Gln
                  95                 100                 105

 Cys His Leu Ser Pro Ile Ser Arg Ser Cys Thr Arg Asn Arg Arg
                 110                 115                 120

 His Val Leu Tyr Pro
                 125

<210> 9
<211> 124
<212> PRT
<213> Homo sapiens

<400> 9
 Met Val Pro Arg Ile Ser Ala Ala Ile Phe Ile Phe Glu Leu Leu
   1               5                  10                  15

 Gly Ser Asn Ser Glu Gly Val Thr Asp Leu Arg Leu Trp Leu Cys
                  20                  25                  30

 Gln Pro Ala Pro Arg Cys Gly Glu Trp Thr Tyr Asn Pro Leu Glu
                  35                  40                  45

 Gln Cys Cys Asp Asp Gly Val Ile Leu Asp Leu Asn Gln Thr Arg
                  50                  55                  60

 Leu Cys Gly Ser Ser Cys Thr Phe Trp Pro Cys Phe Gln His Cys
                  65                  70                  75

 Cys Leu Glu Ser Leu Gly Ser Gln Asn Gln Thr Val Val Arg Phe
                  80                  85                  90

 Lys Val Pro Gly Met Lys Pro Asp Cys Lys Ser Ser Pro Ile Thr
                  95                 100                 105

 Arg Ile Cys Ala Gln Glu Tyr His Pro Lys Ser Pro Val Ser Arg
                 110                 115                 120

 Ser Asp Leu Ile
                

<210> 10
<211> 140
<212> PRT
<213> Mus musculus

<400> 10
 Met Lys Ile Arg Asn Ala Cys Ala Val Leu Ile Glu Val Leu Leu
   1               5                  10                  15

 Phe Ile Leu Glu Gly Val Thr Gly Ala Arg Lys Ile Ser Thr Phe
                  20                  25                  30

 Ser Gly Pro Gly Ser Trp Pro Cys Asn Pro Lys Cys Asp Gly Arg
                  35                  40                  45

 Thr Tyr Asn Pro Ser Glu Glu Cys Cys Val His Asp Thr Ile Leu
                  50                  55                  60

 Pro Phe Lys Arg Ile Asn Leu Cys Gly Pro Ser Cys Thr Tyr Arg
                  65                  70                  75

 Pro Cys Phe Glu Leu Cys Cys Pro Glu Ser Tyr Ser Pro Lys Lys
                  80                  85                  90

 Lys Phe Ile Val Lys Leu Lys Val His Gly Glu Arg Ser His Cys
                  95                 100                 105

 Ser Ser Ser Pro Ile Ser Arg Asn Cys Lys Ser Asn Lys Ile Phe
                 110                 115                 120

 His Gly Glu Asp Ile Glu Asp Asn Gln Leu Ser Leu Arg Lys Lys
                 125                 130                 135

 Ser Gly Asp Gln Pro
                 140

<210> 11
<211> 18
<212> DNA
<213> Homo sapiens

<400> 11
 atggcccatg gcactact 18

<210> 12
<211> 19
<212> DNA
<213> Homo sapiens

<400> 12
 tcagcgaata ggcaaaggt 19

<210> 13
<211> 22
<212> DNA
<213> Homo sapiens

<400> 13
 cagcaggcag cccatatctt gc 22

<210> 14
<211> 20
<212> DNA
<213> Mus musculus

<400> 14
 gccctgattg agatggttgt 20

<210> 15
<211> 20
<212> DNA
<213> Mus musculus

<400> 15
 ccaaatatgt gccgaattga 20

<210> 16
<211> 25
<212> DNA
<213> Mus musculus

<400> 16
 cagagtagca gaaggctccc ttgcc 25

<210> 17
<211> 24
<212> DNA
<213> Homo sapiens

<400> 17
 ctagaattct ggacagcatg agat 24

<210> 18
<211> 18
<212> DNA
<213> Homo sapiens

<400> 18
 gttggccata ggggtcat 18

<210> 19
<211> 23
<212> DNA
<213> Homo sapiens

<400> 19
 cccagggact ctgaaccctc ctg 23

<210> 20
<211> 20
<212> DNA
<213> Homo sapiens

<400> 20
 gcacgtcctg tacccataaa 20

<210> 21
<211> 24
<212> DNA
<213> Homo sapiens

<400> 21
 agttcaactg tagtctccga tgtc 24

<210> 22
<211> 24
<212> DNA
<213> Homo sapiens

<400> 22
 cagctgcttc gtctcttctc ccct 24

<210> 23
<211> 138
<212> PRT
<213> Homo sapiens

<400> 23
 Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp Asn Pro Asp Asn Lys
   1               5                  10                  15

 Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro Pro Pro Cys Pro
                  20                  25                  30

 Asp Tyr Glu Phe Arg Glu Asn Cys Gly Leu Asn Asp His Gly Asp
                  35                  40                  45

 Phe Val Thr Pro Pro Phe Arg Lys Cys Ser Ser Gly Gln Cys Asn
                  50                  55                  60

 Pro Asp Gly Ala Glu Leu Cys Ser Pro Cys Gly Gly Gly Ala Val
                  65                  70                  75

 Thr Pro Thr Pro Ala Ala Gly Gly Gly Arg Thr Pro Trp Arg Cys
                  80                  85                  90

 Arg Glu Arg Pro Val Pro Ala Lys Gly His Cys Pro Leu Thr Pro
                  95                 100                 105

 Gly Asn Pro Gly Ala Pro Ser Ser Gln Glu Arg Ser Ser Pro Ala
                 110                 115                 120

 Ser Ser Ile Ala Trp Arg Thr Pro Glu Pro Val Pro Gln Gln Ala
                 125                 130                 135

 Trp Pro Asn
            

<210> 24
<211> 23
<212> PRT
<213> Homo sapiens

<400> 24
 Met Ala Pro Arg Gly Cys Ile Val Ala Val Phe Ala Ile Phe Cys
   1               5                  10                  15

 Ile Ser Arg Leu Leu Cys Ser His
                  20            

<210> 25
<211> 87
<212> PRT
<213> Homo sapiens

<400> 25
 Gly Ala Pro Val Ala Pro Met Thr Pro Tyr Leu Met Leu Cys Gln
   1               5                  10                  15

 Pro His Lys Arg Cys Gly Asp Lys Phe Tyr Asp Pro Leu Gln His
                  20                  25                  30

 Cys Cys Tyr Asp Asp Ala Val Val Pro Leu Ala Arg Thr Gln Thr
                  35                  40                  45

 Cys Gly Asn Cys Thr Phe Arg Val Cys Phe Glu Gln Cys Cys Pro
                  50                  55                  60

 Trp Thr Phe Met Val Lys Leu Ile Asn Gln Asn Cys Asp Ser Ala
                  65                  70                  75

 Arg Thr Ser Asp Asp Arg Leu Cys Arg Ser Val Ser
                  80                  85        

<210> 26
<211> 29
<212> PRT
<213> Homo sapiens

<400> 26
 Met Arg Thr Asp Tyr Pro Arg Ser Val Leu Ala Pro Ala Tyr Val
   1               5                  10                  15

 Ser Val Cys Leu Leu Leu Leu Cys Pro Arg Glu Val Ile Ala
                  20                  25                

<210> 27
<211> 94
<212> PRT
<213> Homo sapiens

<400> 27
 Pro Ala Gly Ser Glu Pro Trp Leu Cys Gln Pro Ala Pro Arg Cys
   1               5                  10                  15

 Gly Asp Lys Ile Tyr Asn Pro Leu Glu Gln Cys Cys Tyr Asn Asp
                  20                  25                  30

 Ala Ile Val Ser Leu Ser Glu Thr Arg Gln Cys Gly Pro Pro Cys
                  35                  40                  45

 Thr Phe Trp Pro Cys Phe Glu Leu Cys Cys Leu Asp Ser Phe Gly
                  50                  55                  60

 Leu Thr Asn Asp Phe Val Val Lys Leu Lys Val Gln Gly Val Asn
                  65                  70                  75

 Ser Gln Cys His Ser Ser Pro Ile Ser Ser Lys Cys Glu Ser Arg
                  80                  85                  90

 Arg Arg Phe Pro
                

<210> 28
<211> 23
<212> PRT
<213> Homo sapiens

<400> 28
 Met Arg Pro Arg Cys Cys Ile Leu Ala Leu Val Cys Trp Ile Thr
   1               5                  10                  15

 Val Phe Leu Leu Gln Cys Ser Lys
                  20            

<210> 29
<211> 102
<212> PRT
<213> Homo sapiens

<400> 29
 Gly Thr Thr Asp Ala Pro Val Gly Ser Gly Leu Trp Leu Cys Gln
   1               5                  10                  15

 Pro Thr Pro Arg Cys Gly Asn Lys Ile Tyr Asn Pro Ser Glu Gln
                  20                  25                  30

 Cys Cys Tyr Asp Asp Ala Ile Leu Ser Leu Lys Glu Thr Arg Arg
                  35                  40                  45

 Cys Gly Ser Thr Cys Thr Phe Trp Pro Cys Phe Glu Leu Cys Cys
                  50                  55                  60

 Pro Glu Ser Phe Gly Pro Gln Gln Lys Phe Leu Val Lys Leu Arg
                  65                  70                  75

 Val Leu Gly Met Lys Ser Gln Cys His Leu Ser Pro Ile Ser Arg
                  80                  85                  90

 Ser Cys Thr Arg Asn Arg Arg His Val Leu Tyr Pro
                  95                 100        

<210> 30
<211> 19
<212> PRT
<213> Homo sapiens

<400> 30
 Met Val Pro Arg Ile Ser Ala Ala Ile Phe Ile Phe Glu Leu Leu
   1               5                  10                  15

 Gly Ser Asn Ser
                

<210> 31
<211> 105
<212> PRT
<213> Homo sapiens

<400> 31
 Glu Gly Val Thr Asp Leu Arg Leu Trp Leu Cys Gln Pro Ala Pro
   1               5                  10                  15

 Arg Cys Gly Glu Trp Thr Tyr Asn Pro Leu Glu Gln Cys Cys Asp
                  20                  25                  30

 Asp Gly Val Ile Leu Asp Leu Asn Gln Thr Arg Leu Cys Gly Ser
                  35                  40                  45

 Ser Cys Thr Phe Trp Pro Cys Phe Gln His Cys Cys Leu Glu Ser
                  50                  55                  60

 Leu Gly Ser Gln Asn Gln Thr Val Val Arg Phe Lys Val Pro Gly
                  65                  70                  75

 Met Lys Pro Asp Cys Lys Ser Ser Pro Ile Thr Arg Ile Cys Ala
                  80                  85                  90

 Gln Glu Tyr His Pro Lys Ser Pro Val Ser Arg Ser Asp Leu Ile
                  95                 100                 105

<210> 32
<211> 22
<212> PRT
<213> Mus musculus

<400> 32
 Met Lys Ile Arg Asn Ala Cys Ala Val Leu Ile Glu Val Leu Leu
   1               5                  10                  15

 Phe Ile Leu Glu Gly Val Thr
                  20        

<210> 33
<211> 118
<212> PRT
<213> Mus musculus

<400> 33
 Gly Ala Arg Lys Ile Ser Thr Phe Ser Gly Pro Gly Ser Trp Pro
   1               5                  10                  15

 Cys Asn Pro Lys Cys Asp Gly Arg Thr Tyr Asn Pro Ser Glu Glu
                  20                  25                  30

 Cys Cys Val His Asp Thr Ile Leu Pro Phe Lys Arg Ile Asn Leu
                  35                  40                  45

 Cys Gly Pro Ser Cys Thr Tyr Arg Pro Cys Phe Glu Leu Cys Cys
                  50                  55                  60

 Pro Glu Ser Tyr Ser Pro Lys Lys Lys Phe Ile Val Lys Leu Lys
                  65                  70                  75

 Val His Gly Glu Arg Ser His Cys Ser Ser Ser Pro Ile Ser Arg
                  80                  85                  90

 Asn Cys Lys Ser Asn Lys Ile Phe His Gly Glu Asp Ile Glu Asp
                  95                 100                 105

 Asn Gln Leu Ser Leu Arg Lys Lys Ser Gly Asp Gln Pro
                 110                 115            

