                         SEQUENCE LISTING

<110>  MOLOGEN AG
 
<120>  Non-coding immunomodulatory DNA construct

<130>  80523WO

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, lin 30L2

<400>  1
tcattggaaa acgttcttcg gggcgttctt                                        30


<210>  2
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm336


<220>
<221>  misc_feature
<223>  completely in L-conformation, except for the last T

<400>  2
tggaaaacgt tcttcggggc gttcttt                                           27


<210>  3
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm337


<220>
<221>  misc_feature
<223>  1, 2, 29 and 30 in L-conformation

<400>  3
tcattggaaa acgttcttcg gggcgttctt t                                      31


<210>  4
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm338


<220>
<221>  misc_feature
<223>  all but the last phosphodiester bonds modified to phosphothioates

<400>  4
tcattggaaa acgttcttcg gggcgttctt t                                      31


<210>  5
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm339


<220>
<221>  misc_feature
<223>  first two as well as second- and third-to-last phosphodiester 
       bonds modified to phosphothioates

<400>  5
tcattggaaa acgttcttcg gggcgttctt t                                      31


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, ODN2216


<220>
<221>  misc_feature
<223>  all phosphodiester bonds modified to phosphothioates

<400>  6
gggggacgat cgtcgggggg t                                                 21


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm508


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 23-24: in L-conformation

       Nucleotides 3-7 and 17-22: G-stretch

       Nucleotides 9-10, 13-14 and 16-17: CG-motif

<400>  7
gggggggacg atcgtcgggg ggggt                                             25


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm458


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 19-20: in L-conformation

       Nucleotides 4-5 and 15-18: G-stretch

       Nucleotides 7-8, 11-12 and 14-15: CG-motif

<400>  8
ggaggacgat cgtcgggggg t                                                 21


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm481


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 18-19: in L-conformation

       Nucleotides 3-5 and 15-17: G-stretch

       Nucleotides 7-8, 11-12 and 14-15: CG-motif

<400>  9
gggggacgat cgtcgggggt                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm461


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 19-20: in L-conformation

       Nucleotides 5 and 15-18: G-stretch

       Nucleotides 7-8, 11-12 and 14-15: CG-motif

<400>  10
ggaagacgat cgtcgggggg t                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm361-2


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 19-20: in L-conformation

       Nucleotides 3-5 and 15-18: G-stretch

       Nucleotides 7-8, 11-12 and 14-15: CG-motif

<400>  11
gggggacgat cgtcgggggg t                                                 21


<210>  12
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm479


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 20-21: in L-conformation

       Nucleotides 3-6 and 16-19: G-stretch

       Nucleotides 8-9, 12-13 and 15-16: CG-motif

<400>  12
ggggggacga tcgtcggggg gt                                                22


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm503


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 23-24: in L-conformation

       Nucleotides 3-7 and 17-22: G-stretch

       Nucleotides 9-10, 13-14 and 16-17: CG-motif

<400>  13
aagggggacg atcgtcgggg ggaat                                             25


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm507


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 23-24: in L-conformation

       Nucleotides 3-7 and 17-22: G-stretch

       Nucleotides 9-10, 13-14 and 16-17: CG-motif

<400>  14
ttgggggacg atcgtcgggg ggttt                                             25


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm459


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 19-20: in L-conformation

       Nucleotides 3-5, 15-16 and 18: G-stretch

       Nucleotides 7-8, 11-12 and 14-15: CG-motif

<400>  15
gggggacgat cgtcggaggg t                                                 21


<210>  16
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm506


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 20-21: in L-conformation

       Nucleotides 3-5 and 16-19: G-stretch

       Nucleotides 7-8, 11-12 and 15-16: CG-motif

<400>  16
gggggacgat cgtgcggggg gt                                                22


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm478


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 19-20: in L-conformation

       Nucleotides 3-5 and 15-16: G-stretch

       Nucleotides 7-8, 11-12 and 14-15: CG-motif

<400>  17
ggggggcgat cgtcggaagg t                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm480


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 19-20: in L-conformation

       Nucleotides 3-5 and 15-18: G-stretch

       Nucleotides 7-8 and 14-15: CG-motif

<400>  18
gggggacgat gctcgggggg t                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm462


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 19-20: in L-conformation

       Nucleotides 3-5 and 15-16: G-stretch

       Nucleotides 7-8, 11-12 and 14-15: CG-motif

<400>  19
gggggacgat cgtcggaagg t                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm505


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 19-20: in L-conformation

       Nucleotides 3-5 and 16-18 : G-stretch

       Nucleotides 7-8, 11-12 and 15-16: CG-motif

<400>  20
gggggacgat cgtgcggggg t                                                 21


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm476


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 20-21: in L-conformation

       Nucleotides 3-5 and 16-17 : G-stretch

       Nucleotides 8-9, 12-13 and 15-16: CG-motif

<400>  21
gggggaacga tcgtcggaag gt                                                22


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm464


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 19-20: in L-conformation

       Nucleotides 15-18: G-stretch

       Nucleotides 7-8, 11-12 and 14-15: CG-motif

<400>  22
ggcccccgat cgtcgggggg t                                                 21


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm476


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 20-21: in L-conformation

       Nucleotides 3-5 and 16-17: G-stretch

       Nucleotides 8-9, 12-13 and 15-16: CG-motif

<400>  23
gggggaacga tcgtcggaag gt                                                22


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm460


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 19-20: in L-conformation

       Nucleotides 4-5, 15-16 and 18: G-stretch

       Nucleotides 7-8, 11-12 and 14-15: CG-motif

<400>  24
ggaggacgat cgtcggaggg t                                                 21


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm475


<220>
<221>  misc_feature
<223>  Nucleotides 1-7 and 17-21: in L-conformation

       Nucleotides 15-16: G-stretch

       Nucleotides 7-8, 11-12 and 14-15: CG-motif

<400>  25
cccccccgat cgtcgggggg gt                                                22


<210>  26
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm477


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 20-21: in L-conformation

       Nucleotides 3-5 and 16-19: G-stretch

<400>  26
gggggagcat gctgcggggg gt                                                22


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm463


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 19-20: in L-conformation

       Nucleotides 5 and 15-16: G-stretch

       Nucleotides 7-8, 11-12 and 14-15: CG-motif

<400>  27
ggaagacgat cgtcggaagg t                                                 21


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm504


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 19-20: in L-conformation

       Nucleotides 3-5 and 15-18: G-stretch

       Nucleotides 11-12 and 14-15: CG-motif

<400>  28
gggggagcat cgtcgggggg t                                                 21


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm510


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 18-19: in L-conformation

       Nucleotides 3-5, 14-15 and 17: G-stretch

       Nucleotides 6-7, 10-11 and 13-14: CG-motif

<400>  29
gggggcgatc gtcggagggt                                                   20


<210>  30
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm509


<220>
<221>  misc_feature
<223>  Nucleotides 1-6 and 19-23: in L-conformation

       Nucleotides 3-5 and 17-18: G-stretch

       Nucleotides 9-10, 13-14 and 16-17: CG-motif

<400>  30
ccccccctcg atcgtcgggg gggt                                              24


<210>  31
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm532


<220>
<221>  misc_feature
<223>  Nucleotides 32-33: in L-conformation

       Nucleotides 1-4 and 21-24: G-stretch

       Nucleotides 13-14, 20-21 and 25-26: CG-motif

<400>  31
ggggtcatta aacgttcttc ggggcgttct tttt                                   34


<210>  32
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm527


<220>
<221>  misc_feature
<223>  Nucleotides 33-34: in L-conformation

       Nucleotides 1-4, 21-24 and 26-30: G-stretch

       Nucleotides 13-14, 20-21 and 25-26: CG-motif

<400>  32
ggggtcatta aacgttcttc ggggcggggg ttttt                                  35


<210>  33
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm501


<220>
<221>  misc_feature
<223>  Nucleotides 31-32: in L-conformation

       Nucleotides 1-3 and 20-23: G-stretch

       Nucleotides 12-13, 19-20 and 24-25: CG-motif

<400>  33
gggtcattaa acgttcttcg gggcgttctt ttt                                    33


<210>  34
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm534


<220>
<221>  misc_feature
<223>  Nucleotides 32-33: in L-conformation

       Nucleotides 1-3 and 21-24: G-stretch

       Nucleotides 13-14, 20-21 and 25-26: CG-motif

<400>  34
gggtcattaa aacgttcttc ggggcgttct tttt                                   34


<210>  35
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm520


<220>
<221>  misc_feature
<223>  Nucleotides 35-36: in L-conformation

       Nucleotides 1-4 and 28-32: G-stretch

       Nucleotides 13-14, 20-21 and 27-28: CG-motif

<400>  35
ggggtcatta aacgttcttc gttcttcggg ggttttt                                37


<210>  36
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm535


<220>
<221>  misc_feature
<223>  Nucleotides 29-30: in L-conformation

       Nucleotides 17-20 and 22-26: G-stretch

       Nucleotides 9-10, 16-17 and 21-22: CG-motif

<400>  36
tcattaaacg ttcttcgggg cgggggtttt t                                      31


<210>  37
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm528


<220>
<221>  misc_feature
<223>  Nucleotides 31-32: in L-conformation

       Nucleotides 1-3 and 20-23: G-stretch

       Nucleotides 13-14, 19-20 and 24-25: CG-motif

<400>  37
gggtcattaa aacgttctcg gggcgttctt ttt                                    33


<210>  38
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm339


<220>
<221>  misc_feature
<223>  Nucleotides 6-7 and 20-23: G-stretch

       Nucleotides 12-13, 19-20 and 24-25: CG-motif

       Nucleotides 1-2 and 29-30: phosphothioate bonds

<400>  38
tcattggaaa acgttcttcg gggcgttctt                                        30


<210>  39
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm498


<220>
<221>  misc_feature
<223>  Nucleotides 34-35: in L-conformation

       Nucleotides 6-7 and 27-33: G-stretch

       Nucleotides 12-13, 19-20 and 26-27: CG-motif

<400>  39
tcattggaaa acgttcttcg ttcttcgggg gggttt                                 36


<210>  40
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm536


<220>
<221>  misc_feature
<223>  Nucleotides 26-27: in L-conformation

       Nucleotides 1-3 and 16-19: G-stretch

       Nucleotides 8-9, 15-16 and 20-21: CG-motif

<400>  40
gggaaaacgt tcttcggggc gttctttt                                          28


<210>  41
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm499


<220>
<221>  misc_feature
<223>  Nucleotides 31-32: in L-conformation

       Nucleotides 6-8 and 20-23: G-stretch

       Nucleotides 12-13, 19-20 and 24-25: CG-motif

<400>  41
tcattgggaa acgttcttcg gggcgttctt ttt                                    33


<210>  42
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm533


<220>
<221>  misc_feature
<223>  Nucleotides 31-32: in L-conformation

       Nucleotides 1-3, 15-17 and 20-23: G-stretch

       Nucleotides 12-13, 19-20 and 24-25: CG-motif

<400>  42
gggtcattaa acgtgggtcg gggcgttctt ttt                                    33


<210>  43
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm500


<220>
<221>  misc_feature
<223>  Nucleotides 31-32: in L-conformation

       Nucleotides 9-11 and 20-23: G-stretch

       Nucleotides 12-13, 19-20 and 24-25: CG-motif

<400>  43
tcattaaagg gcgttcttcg gggcgttctt ttt                                    33


<210>  44
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm521


<220>
<221>  misc_feature
<223>  Nucleotides 23-24: in L-conformation

       Nucleotides 1-3 and 14-17: G-stretch

       Nucleotides 6-7, 13-14 and 18-19: CG-motif

<400>  44
gggaacgttc ttcggggcgt ctttt                                             25


<210>  45
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm502


<220>
<221>  misc_feature
<223>  Nucleotides 21-22: in L-conformation

       Nucleotides 1-3 and 12-15: G-stretch

       Nucleotides 4-5, 11-12 and 16-17: CG-motif

<400>  45
gggcgttctt cggggcgtct ttt                                               23


<210>  46
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm374


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 29-30: in L-conformation

       Nucleotides 6-7 and 20-23: G-stretch

       Nucleotides 12-13, 19-20 and 24-25: CG-motif

<400>  46
tcattggaaa acgttcttcg gggcgttctt t                                      31


<210>  47
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm497


<220>
<221>  misc_feature
<223>  Nucleotides 31-32: in L-conformation

       Nucleotides 6-7 and 27-30: G-stretch

       Nucleotides 12-13, 19-20 and 26-27: CG-motif

<400>  47
tcattggaaa acgttcttcg ttcttcgggg ttt                                    33


<210>  48
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm524


<220>
<221>  misc_feature
<223>  Nucleotides 31-32: in L-conformation

       Nucleotides 1-3 and 21-24: G-stretch

<400>  48
gggtcattaa agcttcttgc ggggcttctt ttt                                    33


<210>  49
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm525


<220>
<221>  misc_feature
<223>  Nucleotides 1-2 and 29-30: in L-conformation

       Nucleotides 6-7 and 21-24: G-stretch

<400>  49
tcattggaaa agcttcttgc ggggcttctt t                                      31


<210>  50
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm526


<220>
<221>  misc_feature
<223>  Nucleotides 25-26: in L-conformation

       Nucleotides 1-3 and 15-18: G-stretch

       Nucleotides 7-8, 14-15 and 19-20: CG-motif

<400>  50
gggaaacgtt cttcggggcg ttctttt                                           27


<210>  51
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm537


<220>
<221>  misc_feature
<223>  Nucleotides 33-34: in L-conformation

       Nucleotides 1-4, 16-18, 21-24 and 26-30: G-stretch

       Nucleotides 13-14, 20-21 and 25-26: CG-motif

<400>  51
ggggtcatta aacgtgggtc ggggcggggg ttttt                                  35


<210>  52
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligodeoxynucleotide, CKm538


<220>
<221>  misc_feature
<223>  Nucleotides 30-31: in L-conformation

       Nucleotides 1-4, 9-12, 16-19 and 23-27: G-stretch

       Nucleotides 8-9, 15-16 and 22-23: CG-motif

<400>  52
ggggaaacgg ggttcggggt tcgggggttt tt                                     32


