<110>  F. Hoffmann-La Roche AG 
  
<120> Small molecule conjugates for intracellular delivery of biologically active compounds
<130> 27175 WO1 

<150>  US 61/427845
<151>  2010-12-29  

<160> 282

<210> 1 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 1 
acaugaagca gcacgacuu 19 
 
 
<210> 2 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 2 
aagucgugcu gcuucaugu 19 
 
 
<210> 3 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 3 
gcccgacaac cacuaccug 19 
 
 
<210> 4 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 4 
cagguagugg uugucgggc 19 
 
 
<210> 5 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 5 
cgagaagcgc gaucacaug 19 
 
 
<210> 6 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 6 
caugugaucg cgcuucucg 19 
 
 
<210> 7 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 7 
auaucauggc cgacaagca 19 
 
 
<210> 8 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 8 
ugcuugucgg ccaugauau 19 
 
 
<210> 9 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 9 
acaagcugga guacaacua 19 
 
 
<210> 10 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 10 
uaguuguacu ccagcuugu 19 
 
 
<210> 11 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 11 
gcagcucgcc gaccacuac 19 
 
 
<210> 12 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 12 
guaguggucg gcgagcugc 19 
 
 
<210> 13 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 13 
cguccaggag cgcaccauc 19 
 
 
<210> 14 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 14 
gauggugcgc uccuggacg 19 
 
 
<210> 15 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 15 
gcuggaguuc gugaccgcc 19 
 
 
<210> 16 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 16 
ggcggucacg aacuccagc 19 
 
 
<210> 17 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 17 
ccacccugac cuacggcgu 19 
 
 
<210> 18 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 18 
acgccguagg ucagggugg 19 
 
 
<210> 19 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 19 
cgacuucaag gaggacggc 19 
 
 
<210> 20 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 20 
gccguccucc uugaagucg 19 
 
 
<210> 21 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 21 
uucaagaucc gccacaaca 19 
 
 
<210> 22 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 22 
uguuguggcg gaucuugaa 19 
 
 
<210> 23 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 23 
ggcaacuaca agacccgcg 19 
 
 
<210> 24 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 24 
cgcgggucuu guaguugcc 19 
 
 
<210> 25 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 25 
ccggcaagcu gcccgugcc 19 
 
 
<210> 26 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 26 
ggcacgggca gcuugccgg 19 
 
 
<210> 27 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 27 
ugcccauccu ggucgagcu 19 
 
 
<210> 28 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 28 
agcucgacca ggaugggca 19 
 
 
<210> 29 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 29 
caaguucagc guguccggc 19 
 
 
<210> 30 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 30 
gccggacacg cugaacuug 19 
 
 

<210> 31 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 31 
acaugaagca gcacgacuut t 21 
 
 
<210> 32 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 32 
aagucgugcu gcuucaugut t 21 
 
 
<210> 33 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 33 
gcccgacaac cacuaccugt t 21 
 
 
<210> 34 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 34 
cagguagugg uugucgggct t 21 
 
 
<210> 35 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 35 
cgagaagcgc gaucacaugt t 21 
 
 
<210> 36 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 36 
caugugaucg cgcuucucgt t 21 
 
 
<210> 37 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 37 
auaucauggc cgacaagcat t 21 
 
 
<210> 38 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 38 
ugcuugucgg ccaugauaut t 21 
 
 
<210> 39 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 39 
acaagcugga guacaacuat t 21 
 
 
<210> 40 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 40 
uaguuguacu ccagcuugut t 21 
 
 
<210> 41 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 41 
gcagcucgcc gaccacuact t 21 
 
 
<210> 42 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 42 
guaguggucg gcgagcugct t 21 
 
 
<210> 43 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 43 
cguccaggag cgcaccauct t 21 
 
 
<210> 44 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 44 
gauggugcgc uccuggacgt t 21 
 
 
<210> 45 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 45 
gcuggaguuc gugaccgcct t 21 
 
 
<210> 46 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 46 
ggcggucacg aacuccagct t 21 
 
 
<210> 47 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 47 
ccacccugac cuacggcgut t 21 
 
 
<210> 48 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 48 
acgccguagg ucaggguggt t 21 
 
 
<210> 49 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 49 
cgacuucaag gaggacggct t 21 
 
 
<210> 50 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 50 
gccguccucc uugaagucgt t 21 
 
 
<210> 51 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 51 
uucaagaucc gccacaacat t 21 
 
 
<210> 52 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 52 
uguuguggcg gaucuugaat t 21 
 
 
<210> 53 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 53 
ggcaacuaca agacccgcgt t 21 
 
 
<210> 54 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 54 
cgcgggucuu guaguugcct t 21 
 
 
<210> 55 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 55 
ccggcaagcu gcccgugcct t 21 
 
 
<210> 56 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 56 
ggcacgggca gcuugccggt t 21 
 
 
<210> 57 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 57 
ugcccauccu ggucgagcut t 21 
 
 
<210> 58 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 58 
agcucgacca ggaugggcat t 21 
 
 
<210> 59 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 59 
caaguucagc guguccggct t 21 
 
 
<210> 60 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 60 
gccggacacg cugaacuugt t 21 
 
 
<210> 61 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 61 
acaugaagca gcacgacuut t 21 
 
 
<210> 62 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 62 
aagucgugcu gcuucaugut t 21 
 
 
<210> 63 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 63 
gcccgacaac cacuaccugt t 21 
 
 
<210> 64 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 64 
cagguagugg uugucgggct t 21 
 
 
<210> 65 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 65 
cgagaagcgc gaucacaugt t 21 
 
 
<210> 66 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 66 
caugugaucg cgcuucucgt t 21 
 
 
<210> 67 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 67 
auaucauggc cgacaagcat t 21 
 
 
<210> 68 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 68 
ugcuugucgg ccaugauaut t 21 
 
 
<210> 69 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 69 
acaagcugga guacaacuat t 21 
 
 
<210> 70 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 70 
uaguuguacu ccagcuugut t 21 
 
 
<210> 71 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 71 
gcagcucgcc gaccacuact t 21 
 
 
<210> 72 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 72 
guaguggucg gcgagcugct t 21 
 
 
<210> 73 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 73 
cguccaggag cgcaccauct t 21 
 
 
<210> 74 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 74 
gauggugcgc uccuggacgt t 21 
 
 
<210> 75 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 75 
gcuggaguuc gugaccgcct t 21 
 
 
<210> 76 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 76 
ggcggucacg aacuccagct t 21 
 
 
<210> 77 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 77 
ccacccugac cuacggcgut t 21 
 
 
<210> 78 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 78 
acgccguagg ucaggguggt t 21 
 
 
<210> 79 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 79 
cgacuucaag gaggacggct t 21 
 
 
<210> 80 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 80 
gccguccucc uugaagucgt t 21 
 
 
<210> 81 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 81 
uucaagaucc gccacaacat t 21 
 
 
<210> 82 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 82 
uguuguggcg gaucuugaat t 21 
 
 
<210> 83 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 83 
ggcaacuaca agacccgcgt t 21 
 
 
<210> 84 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 84 
cgcgggucuu guaguugcct t 21 
 
 
<210> 85 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 85 
ccggcaagcu gcccgugcct t 21 
 
 
<210> 86 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 86 
ggcacgggca gcuugccggt t 21 
 
 
<210> 87 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 87 
ugcccauccu ggucgagcut t 21 
 
 
<210> 88 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 88 
agcucgacca ggaugggcat t 21 
 
 
<210> 89 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 89 
caaguucagc guguccggct t 21 
 
 
<210> 90 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 90 
gccggacacg cugaacuugt t 21 
 
 
<210> 91 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 91 
acaugaagca gcacgacutt t 21 
 
 
<210> 92 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 6, 8, 12, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 92 
aagtcgugct gcutcaugut t 21 
 
 
<210> 93 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 93 
gcccgacaac cacuaccugt t 21 
 
 
<210> 94 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 10, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 94 
cagguagtgg utgtcgggct t 21 
 
 
<210> 95 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 95 
cgagaagcgc gatcacaugt t 21 
 
 
<210> 96 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 10, 12, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 96 
caugugatcg cgctucucgt t 21 
 
 
<210> 97 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 97 
auaucatggc cgacaagcat t 21 
 
 
<210> 98 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 6, 8, 10, 12, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 98 
ugctugucgg ccatgauaut t 21 
 
 
<210> 99 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 99 
acaagctgga guacaacuat t 21 
 
 
<210> 100 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 6, 8, 12, 14, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 100 
uagtuguact ccagctugut t 21 
 
 
<210> 101 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 101 
gcagcucgcc gaccactact t 21 
 
 
<210> 102 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 102 
gtaguggtcg gcgagcugct t 21 
 
 
<210> 103 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 103 
cgtccaggag cgcaccauct t 21 
 
 
<210> 104 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 8, 10, 12, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 104 
gauggtgcgc ucctggacgt t 21 
 
 
<210> 105 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 5, 7, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 105 
gctggagutc gugaccgcct t 21 
 
 
<210> 106 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 8, 10, 12, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 106 
ggcggtcacg aactccagct t 21 
 
 
<210> 107 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 9, 11, 13, 15, 17 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 107 
ccaccctgac cuacggcgtt t 21 
 
 
<210> 108 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 108 
acgccguagg ucaggguggt t 21 
 
 
<210> 109 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 109 
cgactucaag gaggacggct t 21 
 
 
<210> 110 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 10, 14, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 110 
gccgucctcc utgaagucgt t 21 
 
 
<210> 111 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 111 
tucaagaucc gccacaacat t 21 
 
 
<210> 112 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 8, 10, 12, 14, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 112 
ugutgtggcg gaucutgaat t 21 
 
 
<210> 113 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 113 
ggcaactaca agacccgcgt t 21 
 
 
<210> 114 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 14, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 114 
cgcgggucut gtagutgcct t 21 
 
 
<210> 115 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 115 
ccggcaagcu gcccgugcct t 21 
 
 
<210> 116 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 116 
ggcacgggca gcutgccggt t 21 
 
 
<210> 117 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 3, 5, 9, 11, 15, 17 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 117 
tgcccatccu ggtcgagctt t 21 
 
 
<210> 118 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 6, 8, 10, 12, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 118 
agctcgacca ggatgggcat t 21 
 
 
<210> 119 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 119 
caagtucagc guguccggct t 21 
 
 
<210> 120 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 14, 16 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 120 
gccggacacg ctgaacutgt t 21 
 
 
<210> 121 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 6, 8, 10, 12, 14, 16 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 121 
acatgaagca gcacgactut t 21 
 
 
<210> 122 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 9, 11, 15 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 122 
aagucgtgcu gctucatgtt t 21 
 
 
<210> 123 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 16 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 123 
gcccgacaac cactacctgt t 21 
 
 
<210> 124 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 7, 9, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 124 
caggtagugg tugucgggct t 21 
 
 
<210> 125 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 125 
cgagaagcgc gaucacatgt t 21 
 
 
<210> 126 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 7, 9, 11, 13, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 126 
catgtgaucg cgcutctcgt t 21 
 
 
<210> 127 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 127 
atatcauggc cgacaagcat t 21 
 
 
<210> 128 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 9, 11, 13, 15 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 128 
tgcutgtcgg ccaugatatt t 21 
 
 
<210> 129 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 14, 16 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 129 
acaagcugga gtacaactat t 21 
 
 
<210> 130 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 9, 11, 13, 15 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 130 
tagutgtacu ccagcutgtt t 21 
 
 
<210> 131 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 131 
gcagctcgcc gaccacuact t 21 
 
 
<210> 132 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 7, 9, 11, 13, 15, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 132 
guagtggucg gcgagctgct t 21 
 
 
<210> 133 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 133 
cguccaggag cgcaccatct t 21 
 
 
<210> 134 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 5, 7, 9, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 134 
gatggugcgc tccuggacgt t 21 
 
 
<210> 135 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 10, 14, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 135 
gcuggagtuc gtgaccgcct t 21 
 
 
<210> 136 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 136 
ggcggucacg aacuccagct t 21 
 
 
<210> 137 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 14, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 137 
ccacccugac ctacggcgut t 21 
 
 
<210> 138 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 9, 13, 15, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 138 
acgccgtagg tcagggtggt t 21 
 
 
<210> 139 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 139 
cgacutcaag gaggacggct t 21 
 
 
<210> 140 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 7, 9, 13, 15, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 140 
gccgtccucc tugaagtcgt t 21 
 
 
<210> 141 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 4, 6, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 141 
utcaagatcc gccacaacat t 21 
 
 
<210> 142 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 5, 7, 9, 11, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 142 
tgtuguggcg gatctugaat t 21 
 
 
<210> 143 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 143 
ggcaacuaca agacccgcgt t 21 
 
 
<210> 144 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 11, 13, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 144 
cgcgggtctu guagtugcct t 21 
 
 
<210> 145 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 12, 14, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 145 
ccggcaagct gcccgtgcct t 21 
 
 
<210> 146 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 146 
ggcacgggca gctugccggt t 21 
 
 
<210> 147 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 147 
ugcccaucct ggucgagcut t 21 
 
 
<210> 148 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 148 
agcucgacca ggaugggcat t 21 
 
 
<210> 149 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 8, 10, 16, 18 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 149 
caagutcagc gtgtccggct t 21 
 
 
<210> 150 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 19 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 150 
gccggacacg cugaactugt t 21 
 
 

<210> 151 
<211> 21 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting apoB 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<400> 151 
ggaaucuuau auuugaucca a 21 
 
 
<210> 152 
<211> 23 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting apoB 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<400> 152 
uuggaucaaa uauaagauuc ccu 23 
 
 
<210> 153 
<211> 21 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting apoB 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 7, 8, 10, 12, 13, 14, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "corresponding base 5'-monophosphorothioate" 
  
<400> 153 
ggaaucuuau auuugaucca a 21 
 
 
<210> 154 
<211> 23 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting apoB 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 2, 7, 11, 13, 18, 21 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 23 
<223> /mod_base = "corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 22 
<223> /mod_base = "2'-O-methyl corresponding base 5'-monophosphorothioate" 
  
<400> 154 
uuggaucaaa uauaagauuc ccu 23 
 
 

<210> 155 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<400> 155 
ggaugaagug gagauuagu 19 
 
 
<210> 156 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<400> 156 
acuaaucucc acuucaucc 19 
 
 
<210> 157 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 4, 9, 15, 16, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 1, 2, 3, 5, 6, 7, 8, 10, 11, 12, 13, 14, 17, 18 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 157 
ggaugaagug gagauuagut t 21 
 
 
<210> 158 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 10, 15 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 1, 2, 4, 5, 6, 7, 8, 9, 11, 12, 13, 14, 16, 17, 18, 19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 158 
acuaaucucc acuucaucct t 21 
 
 

<210> 159 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 159 
acuaaucucc acuucaucct  20 
 

<210> 160 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223>  Description of the artificial sequence: antisense strand of dsRNA targeting aha1
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "base with 5'-hexyl amino linker (NH2C6)" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 160 
ggaugaagug gagauuagut  20 
 
 
 

<210> 161 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 161 
gcaaaggcgu gccaacuca 19 
 
 
<210> 162 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 162 
ugaguuggca cgccuuugc 19 
 
 
<210> 163 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 163 
ggaucaucuc aagucuuac 19 
 
 
<210> 164 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 164 
guaagacuug agaugaucc 19 
 
 

<210> 165 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "base with 5'-hexyl amino linker (NH2C6)" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 165 
gcaaaggcgu gccaacucat  20 
 
 
<210> 166 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 166 
ugaguuggca cgccuuugct  20 
 
 
<210> 167 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "base with 5'-hexyl amino linker (NH2C6)" 
  
<220>   
<221> modified_base 
<222> 2, 8, 10, 12, 13, 16, 17, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 1, 3, 4, 5, 6, 7, 9, 11, 14, 15, 19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 167 
gcaaaggcgu gccaacucat t 21 
 
 
<210> 168 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 9 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 1, 2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 168 
ugaguuggca cgccuuugct t 21 
 
 
<210> 169 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "base with 5'-hexyl amino linker (NH2C6)" 
  
<220>   
<221> modified_base 
<222> 4, 5, 7, 8, 9, 10, 14, 15, 16, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 1, 2, 3, 6, 11, 12, 13, 18 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 169 
ggaucaucuc aagucuuact t 21 
 
 
<210> 170 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 7, 8, 9, 14, 17, 18, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 1, 3, 4, 5, 6, 10, 11, 12, 13, 15, 16 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 170 
guaagacuug agaugaucct t 21 
 
 

<210> 171 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting PTPN1 
  
<400> 171 
ugaccacagu cggauuaaa 19 
 
 
<210> 172 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting PTPN1 
  
<400> 172 
uuuaauccga cugugguca 19 
 
 
<210> 173 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting PTPN1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "base with 5'-hexyl amino linker (NH2C6)" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 173 
ugaccacagu cggauuaaat  20 
 
 
<210> 174 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting PTPN1 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 174 
uuuaauccga cuguggucat  20 
 
 
<210> 175 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting PTPN1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "base with 5'-hexyl amino linker (NH2C6)" 
  
<220>   
<221> modified_base 
<222> 1, 4, 5, 7, 10, 11, 15, 16 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 2, 3, 6, 8, 9, 12, 13, 14, 17, 18, 19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 175 
ugaccacagu cggauuaaat t 21 
 
 
<210> 176 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting PTPN1 
  
<220>   
<221> modified_base 
<222> 1, 3, 17, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 176 
uuuaauccga cuguggucat t 21 

  

<210> 177 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting PTPN1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 1, 2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 177 
uuuaauccga cuguggucat t 21 
 
 

<210> 178 
<211> 19 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 2..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 178 
tgaguuggca cgccuuugc 19 
 
 

<210> 179 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-N-Acetylgalactosamine (GalNac) attached via hexyl amino linker (NHC6)" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 179 
gcaaaggcgu gccaacucat  20 
 
 
<210> 180 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
    
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-N-Acetylgalactosamine (GalNac) attached via hexyl amino linker (NHC6)" 
  
<220>   
<221> modified_base 
<222> 2, 8, 10, 12, 13, 16, 17, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 1, 3, 4, 5, 6, 7, 9, 11, 14, 15, 19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 180 
gcaaaggcgu gccaacucat t 21 
 
 
<210> 181 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 181 
gcaaaggcgu gccaacucat  20 
 
 
<210> 182 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 8, 10, 12, 13, 16, 17, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 1, 3, 4, 5, 6, 7, 9, 11, 14, 15, 19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 182 
gcaaaggcgu gccaacucat t 21 
 
 
<210> 183 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
    
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-linked cholesterol compound of formula II" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 183 
gcaaaggcgu gccaacucat  20 
 
 
<210> 184 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<400> 184 
gcaaaggcgu gccaacuca 19 
 
 

<210> 185 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 185 
ugaguuggca cgccuuugct  20 
 
 
<210> 186 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 186 
tgaguuggca cgccuuugct  20 
 
 
<210> 187 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 187 
tgaguuggca cgccuuugct  20 
 
 
<210> 188 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "5'-thio 5'-deoxy" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 188 
tgaguuggca cgccuuugct  20 
 
 
<210> 189 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 189 
tgaguuggca cgccuuugct  20 
 
 
<210> 190 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 190 
ugaguuggca cgccuuugct  20 
 
 
<210> 191 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 191 
ugaguuggca cgccuuugct  20 
 
 
<210> 192 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 192 
ugaguuggca cgccuuugct  20 
 
 
<210> 193 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 193 
ugaguuggca cgccuuugct  20 
 
 
<210> 194 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "5'-thio 5'-deoxy" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 194 
tgaguuggca cgccuuugct  20 
 
 
<210> 195 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 195 
ugaguuggca cgccuuugct  20 
 
 
<210> 196 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 196 
ugaguuggca cgccuuugct  20 
 
 
<210> 197 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 197 
tgaguuggca cgccuuugct  20 
 
 
<210> 198 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 198 
tgaguuggca cgccuuugct  20 
 
 
<210> 199 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "5'-thio 5'-deoxy" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 199 
tgaguuggca cgccuuugct  20 
 
 

<210> 200 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-O-methyl corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 200 
gcuggaguuc gugaccgcct  20 
 
 
<210> 201 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 201 
gcuggaguuc gugaccgcct  20 
 
 
<210> 202 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-O-methyl corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 202 
gcuggaguuc gugaccgcct t 21 
 
 
<210> 203 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 203 
gcuggaguuc gugaccgcct t 21 
 
 
<210> 204 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 204 
gcuggaguuc gugaccgcct  20 
 
 
<210> 205 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-O-methyl corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 205 
gcuggaguuc gugaccgcct  20 
 
 
<210> 206 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 206 
gcuggaguuc gugaccgcct t 21 
 
 
<210> 207 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 207 
gcuggaguuc gugaccgcct t 21 
 
 
<210> 208 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-O-methyl corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 208 
gcuggaguuc gugaccgcct t 21 
 
 
<210> 209 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-O-methyl corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 209 
gcuggaguuc gugaccgcct t 21 
 
 
<210> 210 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-O-methyl corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 210 
gcuggaguuc gugaccgcct t 21 
 
 
<210> 211 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 211 
gcuggaguuc gugaccgcct t 21 
 
 
<210> 212 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 3, 8, 9, 10, 12, 15, 16, 18, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 1, 4, 5, 6, 7, 11, 13, 14, 17 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 212 
gcuggaguuc gugaccgcct t 21 
 
 

<210> 213 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 213 
ggcggucacg aacuccagct t 21 
 
 
<210> 214 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 214 
ggcggucacg aacuccagct t 21 
 
 
<210> 215 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 215 
ggcggucacg aacuccagct t 21 
 
 
<210> 216 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 216 
ggcggucacg aacuccagct t 21 
 
 
<210> 217 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 217 
ggcggucacg aacuccagct  20 
 
 
<210> 218 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 218 
ggcggucacg aacuccagct t 21 
 
 
<210> 219 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 219 
ggcggucacg aacuccagct t 21 
 
 
<210> 220 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 220 
ggcggucacg aacuccagct  20 
 
 
<210> 221 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 221 
ggcggucacg aacuccagct  20 
 
 
<210> 222 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 222 
ggcggucacg aacuccagct t 21 
 
 
<210> 223 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 223 
ggcggucacg aacuccagct t 21 
 
 
<210> 224 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 224 
ggcggucacg aacuccagct  20 
 
 
<210> 225 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting EGFP 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 7, 16 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 225 
ggcggucacg aacuccagct t 21 
 
 

<210> 226 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-O-methyl corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 226 
ggaugaagug gagauuagut t 21 
 
 
<210> 227 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-O-methyl corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 227 
ggaugaagug gagauuagut  20 
 
 
<210> 228 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-O-methyl corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 228 
ggaugaagug gagauuagut t 21 
 
 
<210> 229 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-O-methyl corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 229 
ggaugaagug gagauuagut t 21 
 
 
<210> 230 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 230 
ggaugaagug gagauuagut t 21 
 
 
<210> 231 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-O-methyl corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 231 
ggaugaagug gagauuagut  20 
 
 
<210> 232 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 232 
ggaugaagug gagauuagut  20 
 
 
<210> 233 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 233 
ggaugaagug gagauuagut t 21 
 
 
<210> 234 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 234 
ggaugaagug gagauuagut  20 
 
 
<210> 235 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-O-methyl corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 235 
ggaugaagug gagauuagut t 21 
 
 
<210> 236 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 236 
ggaugaagug gagauuagut t 21 
 
 
<210> 237 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 237 
ggaugaagug gagauuagut t 21 
 
 

<210> 238 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 238 
acuaaucucc acuucaucct t 21 
 
 
<210> 239 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 239 
acuaaucucc acuucaucct t 21 
 
 
<210> 240 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 240 
acuaaucucc acuucaucct t 21 
 
 
<210> 241 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 241 
acuaaucucc acuucaucct  20 
 
 
<210> 242 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 242 
acuaaucucc acuucaucct t 21 
 
 
<210> 243 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 243 
acuaaucucc acuucaucct  20 
 
 
<210> 244 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 244 
acuaaucucc acuucaucct t 21 
 
 
<210> 245 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 245 
acuaaucucc acuucaucct  20 
 
 
<210> 246 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 246 
acuaaucucc acuucaucct  20 
 
 

<210> 247 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 247 
guuggugaau ggagcucag 19 
 
 
<210> 248 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 248 
cugagcucca uucaccaac 19 
 
 
<210> 249 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<400> 249 
gguccuguug uuggugaau 19 
 
 
<210> 250 
<211> 19 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<400> 250 
auucaccaac aacaggacc 19 
 
 

<210> 251 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "base with 5'-hexyl amino linker (NH2C6)" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 251 
guuggugaau ggagcucagt  20 
 
 

<210> 252 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 252 
cugagcucca uucaccaact  20 
 
 

<210> 253 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "base with 5'-hexyl amino linker (NH2C6)" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 253 
gguccuguug uuggugaaut  20 
 
 

<210> 254 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 254 
auucaccaac aacaggacct t 21 
 
 
<210> 255 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 255 
cugagcucca uucaccaact t 21 
 
 

<210> 256 
<211> 19 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 2..19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 256 
tgaguuggca cgccuuugc 19 
 
 

<210> 257 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
    
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-cholesterol compound of formula II" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 257 
gcaaaggcgu gccaacucat  20 
 
 
<210> 258 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA
 
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-cholesterol compound of formula II"
  
<220>   
<221> modified_base 
<222> 2, 8, 10, 12, 13, 16, 17, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 1, 3, 4, 5, 6, 7, 9, 11, 14, 15, 19 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 258 
gcaaaggcgu gccaacucat t 21 
 
 
<210> 259 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
   
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-cholesterol compound of formula II attached via C6SSC6"
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 259 
gcaaaggcgu gccaacucat  20 
 
 
<210> 260 
<211> 23 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
   
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-linked cholesterol compound of formula II" 
  
<220>   
<221> modified_base 
<222> 5, 7, 9, 11, 13, 15, 17, 19, 21 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18, 20, 22 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 23 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<220>   
<221> modified_base 
<222> 1..3 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 260 
aucgcaaagg cgugccaacu cat 23 
 
 
<210> 261 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA 
    
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-linked cathepsin via cholesterol compound of formula II and hexyl amino linker (NHC6)" 
  
<220>   
<221> modified_base 
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 

<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 

<400> 261 
gcaaaggcgu gccaacucat  20 
 
 

<210> 262 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 262 
ugaguuggca cgccuuugct  20 
 
 
<210> 263 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18, 20 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 263 
tgaguuggca cgccuuugct  20 
 
 
<210> 264 
<211> 20 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 20 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 264 
ugaguuggca cgccuuugct  20 
 
 

<210> 265 
<211> 21 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting apoB 
    
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-linked cholesterol compound of formula II" 
  
<220>   
<221> modified_base 
<222> 7, 8, 10, 12, 13, 14, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "corresponding base 5'-monophosphorothioate" 
  
<400> 265 
ggaaucuuau auuugaucca a 21 
 

 
<210> 266 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "2'-deoxy corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 266 
acuaaucucc acuucaucct t 21 
 
 
<210> 267 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 267 
acuaaucucc acuucaucct t 21 
 
 
<210> 268 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting aha1 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<400> 268 
acuaaucucc acuucaucct t 21 
 

<210> 269 
<211> 17 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: PNA probe for detection of SEQ ID NO. 182 (sense strand)  
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "Atto425-conjugated via dual serin linker (Panagen)"

<400> 269 
tgagttggca cgccttt 17 


<210> 270 
<211> 17 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: PNA probe for detection of SEQ ID NO. 168 (antisense strand)  
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "Atto425-conjugated via dual serin linker (Panagen)"

<400> 270 
gcaaaggcgt gccaact 17 

<210> 271 
<211> 22 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting FVII 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  

<400> 271 
ugugcaaagg cgugccaacu ca 22 
 
 
<210> 272 
<211> 23 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting FVII 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<400> 272 
uauugcaaag gcgugccaac uca 23 
 
 
<210> 273 
<211> 23 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting FVII 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<400> 273 
uguugcaaag gcgugccaac uca 23 
 
 
<210> 274 
<211> 23 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting FVII 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<400> 274 
uuaggcaaag gcgugccaac uca 23 
 
 
<210> 275 
<211> 23 
<212> RNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: sense strand of dsRNA targeting FVII 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<400> 275 
uagugcaaag gcgugccaac uca 23 
 
 
<210> 276 
<211> 23 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting FVII  
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-linked cholesterol compound of formula II" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18, 20, 22 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 23 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 276 
uaugcaaagg cgugccaacu cat 23 
 
 
<210> 277 
<211> 23 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting FVII  
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-linked cholesterol compound of formula II" 
  
<220>   
<221> modified_base 
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18, 20, 22 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 23 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 277 
ugugcaaagg cgugccaacu cat 23 
 
 
<210> 278 
<211> 24 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting FVII  
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-linked cholesterol compound of formula II" 
  
<220>   
<221> modified_base 
<222> 1, 3, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 5, 7, 9, 11, 13, 15, 17, 19, 21, 23 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 24 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 278 
uauugcaaag gcgugccaac ucat 24 
 
 
<210> 279 
<211> 24 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting FVII  
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-linked cholesterol compound of formula II" 
  
<220>   
<221> modified_base 
<222> 1, 3, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 5, 7, 9, 11, 13, 15, 17, 19, 21, 23 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 24 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 279 
uguugcaaag gcgugccaac ucat 24 
 
 
<210> 280 
<211> 24 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting FVII  
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-linked cholesterol compound of formula II" 
  
<220>   
<221> modified_base 
<222> 1, 2, 6, 8, 10, 12, 14, 16, 18, 20, 22 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 5, 7, 9, 11, 13, 15, 17, 19, 21, 23 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 24 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<220>   
<221> modified_base 
<222> 3..4 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 280 
uuaggcaaag gcgugccaac ucat 24 
 
 
<210> 281 
<211> 24 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting FVII  
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "nucleoside: lacks 5'-phosphate group" 
  
<220>   
<221> modified_base 
<222> 1 
<223> /mod_base = "5'-linked cholesterol compound of formula II" 
  
<220>   
<221> modified_base 
<222> 1, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 5, 7, 9, 11, 13, 15, 17, 19, 21, 23 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 24 
<223> /mod_base = "3'-3'-linked desoxythymidine" 
  
<220>   
<221> modified_base 
<222> 2..3 
<223> /mod_base = "2'-hydroxy corresponding nucleoside" 
  
<400> 281 
uagugcaaag gcgugccaac ucat 24 
 

<210> 282 
<211> 21 
<212> DNA 
<213> Artificial sequence 
  
<220>   
<223> Description of the artificial sequence: antisense strand of dsRNA targeting FVII 
  
<220>   
<221> modified_base 
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19 
<223> /mod_base = "2'-O-methyl corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 4, 6, 8, 10, 12, 14, 16, 18 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside" 
  
<220>   
<221> modified_base 
<222> 2 
<223> /mod_base = "2'-deoxy-2'-fluoro corresponding base 5'-monophosphorothioate" 
  
<220>   
<221> modified_base 
<222> 21 
<223> /mod_base = "5'-phosphorothioate thymidine" 
  
<400> 282 
tgaguuggca cgccuuugct t 21 
 
 
 

