                         SEQUENCE LISTING

<110>  Hadasit Medical Research Services & Development Limited
 
<120>  PAR1 and PAR2 c-tail peptides and peptide mimetics

<130>  2133132

<150>  US 60/ 428,290
<151>  2010-12-30

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  1

Cys Gln Arg Tyr Val Tyr Ser 
1               5           


<210>  2
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser His Asp Phe Arg Asp His Ala 
1               5               


<210>  3
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser Ile Leu 
1               5                   10          


<210>  4
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser Ile Leu Cys Cys Lys 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser Ile Leu Cys Cys Ala 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser Ile Leu Cys Ala Lys 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser Ile Leu Ala Cys Lys 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser Ile Ala Cys Cys Lys 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser Ala Leu Cys Cys Lys 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  10

Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ala Ile Leu Cys Cys Lys 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Ser Glu Cys Gln Arg Tyr Val Ala Ser Ile Leu Cys Cys Lys 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Ser Glu Cys Gln Arg Tyr Ala Tyr Ser Ile Leu Cys Cys Lys 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  13

Ser Ser Glu Cys Gln Arg Ala Val Tyr Ser Ile Leu Cys Cys Lys 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Ser Glu Cys Gln Ala Tyr Val Tyr Ser Ile Leu Cys Cys Lys 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Ser Glu Cys Ala Arg Tyr Val Tyr Ser Ile Leu Cys Cys Lys 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  16

Ser Ser Glu Ala Gln Arg Tyr Val Tyr Ser Ile Leu Cys Cys Lys 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  17

Ser Ser Ala Cys Gln Arg Tyr Val Tyr Ser Ile Leu Cys Cys Lys 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Ala Glu Cys Gln Arg Tyr Val Tyr Ser Ile Leu Cys Cys Lys 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Ser Glu Cys Gln Arg Tyr Val Tyr Ser Ile Leu Cys Cys Lys 
1               5                   10                  15  


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser His Asp Phe Arg Asp His Ala Glx 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Ala Ala Ala Arg Asp His Ala Glx 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  22

Ser His Asp Phe Ala Ala Ala Ala Glx 
1               5                   


<210>  23
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 1

<400>  23
cccctttgtc tattactttg tttcagctgc tgccagggat catg                        44


<210>  24
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 1

<400>  24
gcatgatccc tggcagcagc tgaaacaaag taatagacaa agggg                       45


<210>  25
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2

<400>  25
cacatgattt cgcggctgct gcaaagaacg ctctcctttg ccg                         43


<210>  26
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2

<400>  26
cggcaaagga gagcgttctt tgcagcagcc gcgaaatcat gtg                         43


<210>  27
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer GAPDH - sense

<400>  27

Cys Cys Ala Cys Cys Cys Ala Thr Gly Gly Cys Ala Ala Ala Thr Thr 
1               5                   10                  15      


Cys Cys Ala Thr Gly Gly Cys 
            20              


<210>  28
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer GAPDH - antisense

<400>  28

Thr Cys Thr Ala Gly Ala Cys Gly Gly Cys Ala Gly Gly Thr Cys Ala 
1               5                   10                  15      


Gly Gly Thr Cys Cys Ala Cys Cys 
            20                  


<210>  29
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer hPar1-sense

<400>  29

Cys Thr Cys Gly Thr Cys Cys Thr Cys Ala Ala Gly Gly Ala Gly Cys 
1               5                   10                  15      


Ala Ala Ala Cys 
            20  


<210>  30
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer hPar1- antisense

<400>  30

Thr Gly Gly Gly Ala Thr Cys Gly Gly Ala Ala Cys Thr Thr Thr Cys 
1               5                   10                  15      


Thr Thr Thr Gly 
            20  


<210>  31
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-tail primer - sense

<400>  31

Thr Ala Cys Thr Ala Thr Thr Ala Cys Gly Cys Thr Gly Gly Ala Thr 
1               5                   10                  15      


Cys Cys Thr Cys Thr Gly Ala Gly 
            20                  


<210>  32
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-tail primer - antisense

<400>  32

Cys Thr Thr Gly Ala Ala Thr Thr Cys Cys Thr Ala Ala Gly Thr Thr 
1               5                   10                  15      


Ala Ala Cys Ala Gly Cys Thr Thr 
            20                  


<210>  33
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  entire PAR1 C-tail site

<400>  33

Tyr Tyr Tyr Ala Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser Ile Leu 
1               5                   10                  15      


Cys Cys Lys Glu Ser Ser Asp Pro Ser Tyr Asn Ser Ser Gly Gln Leu 
            20                  25                  30          


Met Ala Ser Lys Met Asp Thr Cys Ser Ser Asn Leu Asn Asn Ser Ile 
        35                  40                  45              


Tyr Lys Lys Leu Leu Thr 
    50                  


<210>  34
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  34

Ser Phe Leu Leu Arg Asn 
1               5       


<210>  35
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  35

Thr Phe Leu Leu Arg Asn Pro Asn Asp Lys 
1               5                   10  


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y397Z primer - sense

<400>  36
ataagcattg accggtttct g                                                 21


<210>  37
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y397Z primer - antisense

<400>  37

Gly Cys Thr Cys Thr Ala Gly Ala Thr Thr Thr Thr Ala Ala Cys Thr 
1               5                   10                  15      


Gly Cys Thr Gly Gly Gly Ala Thr Cys Gly Gly Ala Ala Cys 
            20                  25                  30  


<210>  38
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer 381- sense

<400>  38

Thr Gly Cys Cys Ala Gly Ala Gly Gly Gly Cys Thr Gly Thr Cys Thr 
1               5                   10                  15      


Ala Cys Ala Gly Thr Ala Thr Cys Thr Thr Ala Thr Gly Cys 
            20                  25                  30  


<210>  39
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer 381 - antisense

<400>  39

Gly Ala Thr Ala Cys Thr Gly Thr Ala Gly Ala Cys Ala Gly Cys Cys 
1               5                   10                  15      


Cys Thr Cys Thr Gly Gly Cys Ala Cys Thr Cys Ala Gly Ala 
            20                  25                  30  


<210>  40
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer 383 - sense

<400>  40

Gly Cys Cys Ala Gly Ala Gly Gly Thr Ala Cys Gly Thr Cys Gly Cys 
1               5                   10                  15      


Ala Ala Gly Thr Ala Thr Cys Thr Thr Ala Thr Gly Cys Thr Gly Cys 
            20                  25                  30          


Ala Ala Ala 
        35  


<210>  41
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer 383- antisense

<400>  41

Ala Ala Gly Ala Thr Ala Cys Thr Thr Gly Cys Gly Ala Cys Gly Thr 
1               5                   10                  15      


Ala Cys Cys Thr Cys Thr Gly Gly Cys Ala Cys Thr Cys Ala Gly 
            20                  25                  30      


<210>  42
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  42

Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser Ile Leu Cys Cys 
1               5                   10                  


<210>  43
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  43

Ser Ser Glu Ala Ala Ala Ala Ala Ala Ala Ile Leu Cys Cys 
1               5                   10                  


<210>  44
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer for HA-tag - sense

<400>  44

Thr Ala Cys Cys Cys Ala Thr Ala Cys Gly Ala Thr Gly Thr Thr Cys 
1               5                   10                  15      


Cys Ala Gly Ala Thr Thr Ala Cys Gly Cys Thr 
            20                  25          


<210>  45
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer for HA-tag - antisense

<400>  45

Ala Gly Cys Gly Thr Ala Ala Thr Cys Thr Gly Gly Ala Ala Cys Ala 
1               5                   10                  15      


Thr Cys Thr Ala Thr Gly Gly Gly Thr Ala 
            20                  25      


<210>  46
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer hPar17A mutant - sense

<400>  46

Thr Cys Thr Gly Ala Gly Gly Cys Thr Gly Cys Thr Gly Cys Thr Gly 
1               5                   10                  15      


Cys Thr Gly Cys Thr Gly Cys Ala Gly Cys Thr Ala Thr Cys Thr Thr 
            20                  25                  30          


Ala 
    


<210>  47
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer hPAr17A mutant - antisense

<400>  47

Thr Ala Ala Gly Ala Thr Ala Gly Cys Thr Gly Cys Ala Gly Cys Ala 
1               5                   10                  15      


Gly Cys Ala Gly Cys Ala Gly Cys Ala Gly Cys Cys Thr Cys Ala Gly 
            20                  25                  30          


Ala 
    


<210>  48
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  48

Thr Ala Cys Thr Ala Thr Thr Ala Cys Gly Cys Thr Gly Gly Ala Thr 
1               5                   10                  15      


Cys Cys Thr Cys Thr Gly Ala Gly 
            20                  


<210>  49
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  49

Cys Thr Gly Ala Ala Thr Thr Cys Cys Thr Ala Ala Gly Thr Thr Ala 
1               5                   10                  15      


Ala Cys Ala Gly Cys Thr Thr 
            20              


<210>  50
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  50

Cys Leu Leu Arg Asn Pro Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp 
1               5                   10                  15      


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  symthetic peptide

<400>  51

Lys Ser Ser Pro Leu Gln Lys Gln Leu Pro Ala Phe Ile Ser Cys 
1               5                   10                  15  


<210>  52
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  52

Ser Phe Leu Leu Arg Asn Pro Asn Asp Lys 
1               5                   10  


<210>  53
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer for the cloning siRNA-hPar2

<400>  53

Thr Gly Gly Gly Ala Ala Gly Ala Ala Gly Cys Cys Thr Thr Ala Thr 
1               5                   10                  15      


Thr Gly Gly Thr Ala Thr Thr Cys Ala Ala Gly Ala Gly Ala Thr Ala 
            20                  25                  30          


Cys Cys Ala Ala Thr Ala Ala Gly Gly Cys Thr Thr Cys Thr Thr Cys 
        35                  40                  45              


Cys Cys Thr Thr Thr Thr Thr Thr Cys 
    50                  55          


<210>  54
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer for the cloning of siRNA-hPar2

<400>  54

Thr Cys Gly Ala Gly Ala Ala Ala Ala Ala Ala Gly Gly Gly Ala Ala 
1               5                   10                  15      


Gly Ala Ala Gly Cys Cys Thr Thr Ala Thr Thr Gly Gly Thr Ala Thr 
            20                  25                  30          


Cys Thr Cys Thr Thr Gly Ala Ala Thr Ala Cys Cys Ala Ala Thr Ala 
        35                  40                  45              


Ala Gly Gly Cys Thr Thr Cys Thr Thr Cys Cys Cys Ala 
    50                  55                  60      


