                         SEQUENCE LISTING

<110>  Krizman, David B.
       Darfler, Marlene M
       Conrads, Thomas P
       Hood, Brian L
       Bateman, Nicholas W
 
<120>  PROTEIN BIOMARKERS OF RECURRENT BREAST CANCER

<130>  01152.8018.WO00

<150>  US 61/428,145
<151>  2010-12-29

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Cys Glu Glu Glu Asp Ser Thr Ala Leu Val Cys Asp Asn Gly Ser 
1               5                   10                  15      


Gly Leu Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
            20                  25                  30          


Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
        35                  40                  45              


Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
    50                  55                  60                  


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
65                  70                  75                  80  


Trp Asp Asp Met Glu Lys Ile Trp His His Ser Phe Tyr Asn Glu Leu 
                85                  90                  95      


Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
            100                 105                 110         


Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
        115                 120                 125             


Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
    130                 135                 140                 


Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
145                 150                 155                 160 


Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                165                 170                 175     


Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
            180                 185                 190         


Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
        195                 200                 205             


Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
    210                 215                 220                 


Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
225                 230                 235                 240 


Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                245                 250                 255     


Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
            260                 265                 270         


Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
        275                 280                 285             


Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
    290                 295                 300                 


Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
305                 310                 315                 320 


Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                325                 330                 335     


Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
            340                 345                 350         


Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
        355                 360                 365             


Pro Ser Ile Val His Arg Lys Cys Phe 
    370                 375         


<210>  2
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  3
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Asp Lys Leu Pro Tyr Lys Val Ala Asp Ile Gly Leu Ala Ala 
1               5                   10                  15      


Trp Gly Arg Lys Ala Leu Asp Ile Ala Glu Asn Glu Met Pro Gly Leu 
            20                  25                  30          


Met Arg Met Arg Glu Arg Tyr Ser Ala Ser Lys Pro Leu Lys Gly Ala 
        35                  40                  45              


Arg Ile Ala Gly Cys Leu His Met Thr Val Glu Thr Ala Val Leu Ile 
    50                  55                  60                  


Glu Thr Leu Val Thr Leu Gly Ala Glu Val Gln Trp Ser Ser Cys Asn 
65                  70                  75                  80  


Ile Phe Ser Thr Gln Asp His Ala Ala Ala Ala Ile Ala Lys Ala Gly 
                85                  90                  95      


Ile Pro Val Tyr Ala Trp Lys Gly Glu Thr Asp Glu Glu Tyr Leu Trp 
            100                 105                 110         


Cys Ile Glu Gln Thr Leu Tyr Phe Lys Asp Gly Pro Leu Asn Met Ile 
        115                 120                 125             


Leu Asp Asp Gly Gly Asp Leu Thr Asn Leu Ile His Thr Lys Tyr Pro 
    130                 135                 140                 


Gln Leu Leu Pro Gly Ile Arg Gly Ile Ser Glu Glu Thr Thr Thr Gly 
145                 150                 155                 160 


Val His Asn Leu Tyr Lys Met Met Ala Asn Gly Ile Leu Lys Val Pro 
                165                 170                 175     


Ala Ile Asn Val Asn Asp Ser Val Thr Lys Ser Lys Phe Asp Asn Leu 
            180                 185                 190         


Tyr Gly Cys Arg Glu Ser Leu Ile Asp Gly Ile Lys Arg Ala Thr Asp 
        195                 200                 205             


Val Met Ile Ala Gly Lys Val Ala Val Val Ala Gly Tyr Gly Asp Val 
    210                 215                 220                 


Gly Lys Gly Cys Ala Gln Ala Leu Arg Gly Phe Gly Ala Arg Val Ile 
225                 230                 235                 240 


Ile Thr Glu Ile Asp Pro Ile Asn Ala Leu Gln Ala Ala Met Glu Gly 
                245                 250                 255     


Tyr Glu Val Thr Thr Met Asp Glu Ala Cys Gln Glu Gly Asn Ile Phe 
            260                 265                 270         


Val Thr Thr Thr Gly Cys Ile Asp Ile Ile Leu Gly Arg His Phe Glu 
        275                 280                 285             


Gln Met Lys Asp Asp Ala Ile Val Cys Asn Ile Gly His Phe Asp Val 
    290                 295                 300                 


Glu Ile Asp Val Lys Trp Leu Asn Glu Asn Ala Val Glu Lys Val Asn 
305                 310                 315                 320 


Ile Lys Pro Gln Val Asp Arg Tyr Arg Leu Lys Asn Gly Arg Arg Ile 
                325                 330                 335     


Ile Leu Leu Ala Glu Gly Arg Leu Val Asn Leu Gly Cys Ala Met Gly 
            340                 345                 350         


His Pro Ser Phe Val Met Ser Asn Ser Phe Thr Asn Gln Val Met Ala 
        355                 360                 365             


Gln Ile Glu Leu Trp Thr His Pro Asp Lys Tyr Pro Val Gly Val His 
    370                 375                 380                 


Phe Leu Pro Lys Lys Leu Asp Glu Ala Val Ala Glu Ala His Leu Gly 
385                 390                 395                 400 


Lys Leu Asn Val Lys Leu Thr Lys Leu Thr Glu Lys Gln Ala Gln Tyr 
                405                 410                 415     


Leu Gly Met Ser Cys Asp Gly Pro Phe Lys Pro Asp His Tyr Arg Tyr 
            420                 425                 430         


<210>  4
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  5
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Lys Pro Ala Gln Gly Ala Lys Tyr Arg Gly Ser Ile His Asp 
1               5                   10                  15      


Phe Pro Gly Phe Asp Pro Asn Gln Asp Ala Glu Ala Leu Tyr Thr Ala 
            20                  25                  30          


Met Lys Gly Phe Gly Ser Asp Lys Glu Ala Ile Leu Asp Ile Ile Thr 
        35                  40                  45              


Ser Arg Ser Asn Arg Gln Arg Gln Glu Val Cys Gln Ser Tyr Lys Ser 
    50                  55                  60                  


Leu Tyr Gly Lys Asp Leu Ile Ala Asp Leu Lys Tyr Glu Leu Thr Gly 
65                  70                  75                  80  


Lys Phe Glu Arg Leu Ile Val Gly Leu Met Arg Pro Pro Ala Tyr Cys 
                85                  90                  95      


Asp Ala Lys Glu Ile Lys Asp Ala Ile Ser Gly Ile Gly Thr Asp Glu 
            100                 105                 110         


Lys Cys Leu Ile Glu Ile Leu Ala Ser Arg Thr Asn Glu Gln Met His 
        115                 120                 125             


Gln Leu Val Ala Ala Tyr Lys Asp Ala Tyr Glu Arg Asp Leu Glu Ala 
    130                 135                 140                 


Asp Ile Ile Gly Asp Thr Ser Gly His Phe Gln Lys Met Leu Val Val 
145                 150                 155                 160 


Leu Leu Gln Gly Thr Arg Glu Glu Asp Asp Val Val Ser Glu Asp Leu 
                165                 170                 175     


Val Gln Gln Asp Val Gln Asp Leu Tyr Glu Ala Gly Glu Leu Lys Trp 
            180                 185                 190         


Gly Thr Asp Glu Ala Gln Phe Ile Tyr Ile Leu Gly Asn Arg Ser Lys 
        195                 200                 205             


Gln His Leu Arg Leu Val Phe Asp Glu Tyr Leu Lys Thr Thr Gly Lys 
    210                 215                 220                 


Pro Ile Glu Ala Ser Ile Arg Gly Glu Leu Ser Gly Asp Phe Glu Lys 
225                 230                 235                 240 


Leu Met Leu Ala Val Val Lys Cys Ile Arg Ser Thr Pro Glu Tyr Phe 
                245                 250                 255     


Ala Glu Arg Leu Phe Lys Ala Met Lys Gly Leu Gly Thr Arg Asp Asn 
            260                 265                 270         


Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Leu Asp Met Leu Asp 
        275                 280                 285             


Ile Arg Glu Ile Phe Arg Thr Lys Tyr Glu Lys Ser Leu Tyr Ser Met 
    290                 295                 300                 


Ile Lys Asn Asp Thr Ser Gly Glu Tyr Lys Lys Thr Leu Leu Lys Leu 
305                 310                 315                 320 


Ser Gly Gly Asp Asp Asp Ala Ala Gly Gln Phe Phe Pro Glu Ala Ala 
                325                 330                 335     


Gln Val Ala Tyr Gln Met Trp Glu Leu Ser Ala Val Ala Arg Val Glu 
            340                 345                 350         


Leu Lys Gly Thr Val Arg Pro Ala Asn Asp Phe Asn Pro Asp Ala Asp 
        355                 360                 365             


Ala Lys Ala Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Asp 
    370                 375                 380                 


Thr Ile Ile Asp Ile Ile Thr His Arg Ser Asn Val Gln Arg Gln Gln 
385                 390                 395                 400 


Ile Arg Gln Thr Phe Lys Ser His Phe Gly Arg Asp Leu Met Thr Asp 
                405                 410                 415     


Leu Lys Ser Glu Ile Ser Gly Asp Leu Ala Arg Leu Ile Leu Gly Leu 
            420                 425                 430         


Met Met Pro Pro Ala His Tyr Asp Ala Lys Gln Leu Lys Lys Ala Met 
        435                 440                 445             


Glu Gly Ala Gly Thr Asp Glu Lys Ala Leu Ile Glu Ile Leu Ala Thr 
    450                 455                 460                 


Arg Thr Asn Ala Glu Ile Arg Ala Ile Asn Glu Ala Tyr Lys Glu Asp 
465                 470                 475                 480 


Tyr His Lys Ser Leu Glu Asp Ala Leu Ser Ser Asp Thr Ser Gly His 
                485                 490                 495     


Phe Arg Arg Ile Leu Ile Ser Leu Ala Thr Gly His Arg Glu Glu Gly 
            500                 505                 510         


Gly Glu Asn Leu Asp Gln Ala Arg Glu Asp Ala Gln Val Ala Ala Glu 
        515                 520                 525             


Ile Leu Glu Ile Ala Asp Thr Pro Ser Gly Asp Lys Thr Ser Leu Glu 
    530                 535                 540                 


Thr Arg Phe Met Thr Ile Leu Cys Thr Arg Ser Tyr Pro His Leu Arg 
545                 550                 555                 560 


Arg Val Phe Gln Glu Phe Ile Lys Met Thr Asn Tyr Asp Val Glu His 
                565                 570                 575     


Thr Ile Lys Lys Glu Met Ser Gly Asp Val Arg Asp Ala Phe Val Ala 
            580                 585                 590         


Ile Val Gln Ser Val Lys Asn Lys Pro Leu Phe Phe Ala Asp Lys Leu 
        595                 600                 605             


Tyr Lys Ser Met Lys Gly Ala Gly Thr Asp Glu Lys Thr Leu Thr Arg 
    610                 615                 620                 


Ile Met Val Ser Arg Ser Glu Ile Asp Leu Leu Asn Ile Arg Arg Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Tyr Asp Lys Ser Leu His Gln Ala Ile Glu Gly Asp 
                645                 650                 655     


Thr Ser Gly Asp Phe Leu Lys Ala Leu Leu Ala Leu Cys Gly Gly Glu 
            660                 665                 670         


Asp 
    


<210>  6
<211>  1339
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Ala Gly Ala Arg Leu Ser Pro Gly Pro Gly Ser Gly Leu 
1               5                   10                  15      


Arg Gly Arg Pro Arg Leu Cys Phe His Pro Gly Pro Pro Pro Leu Leu 
            20                  25                  30          


Pro Leu Leu Leu Leu Phe Leu Leu Leu Leu Pro Pro Pro Pro Leu Leu 
        35                  40                  45              


Ala Gly Ala Thr Ala Ala Ala Ser Arg Glu Pro Asp Ser Pro Cys Arg 
    50                  55                  60                  


Leu Lys Thr Val Thr Val Ser Thr Leu Pro Ala Leu Arg Glu Ser Asp 
65                  70                  75                  80  


Ile Gly Trp Ser Gly Ala Arg Ala Gly Ala Gly Ala Gly Thr Gly Ala 
                85                  90                  95      


Gly Ala Ala Ala Ala Ala Ala Ser Pro Gly Ser Pro Gly Ser Ala Gly 
            100                 105                 110         


Thr Ala Ala Glu Ser Arg Leu Leu Leu Phe Val Arg Asn Glu Leu Pro 
        115                 120                 125             


Gly Arg Ile Ala Val Gln Asp Asp Leu Asp Asn Thr Glu Leu Pro Phe 
    130                 135                 140                 


Phe Thr Leu Glu Met Ser Gly Thr Ala Ala Asp Ile Ser Leu Val His 
145                 150                 155                 160 


Trp Arg Gln Gln Trp Leu Glu Asn Gly Thr Leu Tyr Phe His Val Ser 
                165                 170                 175     


Met Ser Ser Ser Gly Gln Leu Ala Gln Ala Thr Ala Pro Thr Leu Gln 
            180                 185                 190         


Glu Pro Ser Glu Ile Val Glu Glu Gln Met His Ile Leu His Ile Ser 
        195                 200                 205             


Val Met Gly Gly Leu Ile Ala Leu Leu Leu Leu Leu Leu Val Phe Thr 
    210                 215                 220                 


Val Ala Leu Tyr Ala Gln Arg Arg Trp Gln Lys Arg Arg Arg Ile Pro 
225                 230                 235                 240 


Gln Lys Ser Ala Ser Thr Glu Ala Thr His Glu Ile His Tyr Ile Pro 
                245                 250                 255     


Ser Val Leu Leu Gly Pro Gln Ala Arg Glu Ser Phe Arg Ser Ser Arg 
            260                 265                 270         


Leu Gln Thr His Asn Ser Val Ile Gly Val Pro Ile Arg Glu Thr Pro 
        275                 280                 285             


Ile Leu Asp Asp Tyr Asp Cys Glu Glu Asp Glu Glu Pro Pro Arg Arg 
    290                 295                 300                 


Ala Asn His Val Ser Arg Glu Asp Glu Phe Gly Ser Gln Val Thr His 
305                 310                 315                 320 


Thr Leu Asp Ser Leu Gly His Pro Gly Glu Glu Lys Val Asp Phe Glu 
                325                 330                 335     


Lys Lys Ala Ala Ala Glu Ala Thr Gln Glu Thr Val Glu Ser Leu Met 
            340                 345                 350         


Gln Lys Phe Lys Glu Ser Phe Arg Ala Asn Thr Pro Ile Glu Ile Gly 
        355                 360                 365             


Gln Leu Gln Pro Pro Leu Arg Ser Thr Ser Ala Gly Lys Arg Lys Arg 
    370                 375                 380                 


Arg Ser Lys Ser Arg Gly Gly Ile Ser Phe Gly Arg Ala Lys Gly Thr 
385                 390                 395                 400 


Ser Gly Ser Glu Ala Asp Asp Glu Thr Gln Leu Thr Phe Tyr Thr Glu 
                405                 410                 415     


Gln Tyr Arg Ser Arg Arg Arg Ser Lys Gly Leu Leu Lys Ser Pro Val 
            420                 425                 430         


Asn Lys Thr Ala Leu Thr Leu Ile Ala Val Ser Ser Cys Ile Leu Ala 
        435                 440                 445             


Met Val Cys Gly Ser Gln Met Ser Cys Pro Leu Thr Val Lys Val Thr 
    450                 455                 460                 


Leu His Val Pro Glu His Phe Ile Ala Asp Gly Ser Ser Phe Val Val 
465                 470                 475                 480 


Ser Glu Gly Ser Tyr Leu Asp Ile Ser Asp Trp Leu Asn Pro Ala Lys 
                485                 490                 495     


Leu Ser Leu Tyr Tyr Gln Ile Asn Ala Thr Ser Pro Trp Val Arg Asp 
            500                 505                 510         


Leu Cys Gly Gln Arg Thr Thr Asp Ala Cys Glu Gln Leu Cys Asp Pro 
        515                 520                 525             


Glu Thr Gly Glu Cys Ser Cys His Glu Gly Tyr Ala Pro Asp Pro Val 
    530                 535                 540                 


His Arg His Leu Cys Val Arg Ser Asp Trp Gly Gln Ser Glu Gly Pro 
545                 550                 555                 560 


Trp Pro Tyr Thr Thr Leu Glu Arg Gly Tyr Asp Leu Val Thr Gly Glu 
                565                 570                 575     


Gln Ala Pro Glu Lys Ile Leu Arg Ser Thr Phe Ser Leu Gly Gln Gly 
            580                 585                 590         


Leu Trp Leu Pro Val Ser Lys Ser Phe Val Val Pro Pro Val Glu Leu 
        595                 600                 605             


Ser Ile Asn Pro Leu Ala Ser Cys Lys Thr Asp Val Leu Val Thr Glu 
    610                 615                 620                 


Asp Pro Ala Asp Val Arg Glu Glu Ala Met Leu Ser Thr Tyr Phe Glu 
625                 630                 635                 640 


Thr Ile Asn Asp Leu Leu Ser Ser Phe Gly Pro Val Arg Asp Cys Ser 
                645                 650                 655     


Arg Asn Asn Gly Gly Cys Thr Arg Asn Phe Lys Cys Val Ser Asp Arg 
            660                 665                 670         


Gln Val Asp Ser Ser Gly Cys Val Cys Pro Glu Glu Leu Lys Pro Met 
        675                 680                 685             


Lys Asp Gly Ser Gly Cys Tyr Asp His Ser Lys Gly Ile Asp Cys Ser 
    690                 695                 700                 


Asp Gly Phe Asn Gly Gly Cys Glu Gln Leu Cys Leu Gln Gln Thr Leu 
705                 710                 715                 720 


Pro Leu Pro Tyr Asp Ala Thr Ser Ser Thr Ile Phe Met Phe Cys Gly 
                725                 730                 735     


Cys Val Glu Glu Tyr Lys Leu Ala Pro Asp Gly Lys Ser Cys Leu Met 
            740                 745                 750         


Leu Ser Asp Val Cys Glu Gly Pro Lys Cys Leu Lys Pro Asp Ser Lys 
        755                 760                 765             


Phe Asn Asp Thr Leu Phe Gly Glu Met Leu His Gly Tyr Asn Asn Arg 
    770                 775                 780                 


Thr Gln His Val Asn Gln Gly Gln Val Phe Gln Met Thr Phe Arg Glu 
785                 790                 795                 800 


Asn Asn Phe Ile Lys Asp Phe Pro Gln Leu Ala Asp Gly Leu Leu Val 
                805                 810                 815     


Ile Pro Leu Pro Val Glu Glu Gln Cys Arg Gly Val Leu Ser Glu Pro 
            820                 825                 830         


Leu Pro Asp Leu Gln Leu Leu Thr Gly Asp Ile Arg Tyr Asp Glu Ala 
        835                 840                 845             


Met Gly Tyr Pro Met Val Gln Gln Trp Arg Val Arg Ser Asn Leu Tyr 
    850                 855                 860                 


Arg Val Lys Leu Ser Thr Ile Thr Leu Ala Ala Gly Phe Thr Asn Val 
865                 870                 875                 880 


Leu Lys Ile Leu Thr Lys Glu Ser Ser Arg Glu Glu Leu Leu Ser Phe 
                885                 890                 895     


Ile Gln His Tyr Gly Ser His Tyr Ile Ala Glu Ala Leu Tyr Gly Ser 
            900                 905                 910         


Glu Leu Thr Cys Ile Ile His Phe Pro Ser Lys Lys Val Gln Gln Gln 
        915                 920                 925             


Leu Trp Leu Gln Tyr Gln Lys Glu Thr Thr Glu Leu Gly Ser Lys Lys 
    930                 935                 940                 


Glu Leu Lys Ser Met Pro Phe Ile Thr Tyr Leu Ser Gly Leu Leu Thr 
945                 950                 955                 960 


Ala Gln Met Leu Ser Asp Asp Gln Leu Ile Ser Gly Val Glu Ile Arg 
                965                 970                 975     


Cys Glu Glu Lys Gly Arg Cys Pro Ser Thr Cys His Leu Cys Arg Arg 
            980                 985                 990         


Pro Gly Lys Glu Gln Leu Ser Pro  Thr Pro Val Leu Leu  Glu Ile Asn 
        995                 1000                 1005             


Arg Val  Val Pro Leu Tyr Thr  Leu Ile Gln Asp Asn  Gly Thr Lys 
    1010                 1015                 1020             


Glu Ala  Phe Lys Ser Ala Leu  Met Ser Ser Tyr Trp  Cys Ser Gly 
    1025                 1030                 1035             


Lys Gly  Asp Val Ile Asp Asp  Trp Cys Arg Cys Asp  Leu Ser Ala 
    1040                 1045                 1050             


Phe Asp  Ala Asn Gly Leu Pro  Asn Cys Ser Pro Leu  Leu Gln Pro 
    1055                 1060                 1065             


Val Leu  Arg Leu Ser Pro Thr  Val Glu Pro Ser Ser  Thr Val Val 
    1070                 1075                 1080             


Ser Leu  Glu Trp Val Asp Val  Gln Pro Ala Ile Gly  Thr Lys Val 
    1085                 1090                 1095             


Ser Asp  Tyr Ile Leu Gln His  Lys Lys Val Asp Glu  Tyr Thr Asp 
    1100                 1105                 1110             


Thr Asp  Leu Tyr Thr Gly Glu  Phe Leu Ser Phe Ala  Asp Asp Leu 
    1115                 1120                 1125             


Leu Ser  Gly Leu Gly Thr Ser  Cys Val Ala Ala Gly  Arg Ser His 
    1130                 1135                 1140             


Gly Glu  Val Pro Glu Val Ser  Ile Tyr Ser Val Ile  Phe Lys Cys 
    1145                 1150                 1155             


Leu Glu  Pro Asp Gly Leu Tyr  Lys Phe Thr Leu Tyr  Ala Val Asp 
    1160                 1165                 1170             


Thr Arg  Gly Arg His Ser Glu  Leu Ser Thr Val Thr  Leu Arg Thr 
    1175                 1180                 1185             


Ala Cys  Pro Leu Val Asp Asp  Asn Lys Ala Glu Glu  Ile Ala Asp 
    1190                 1195                 1200             


Lys Ile  Tyr Asn Leu Tyr Asn  Gly Tyr Thr Ser Gly  Lys Glu Gln 
    1205                 1210                 1215             


Gln Met  Ala Tyr Asn Thr Leu  Met Glu Val Ser Ala  Ser Met Leu 
    1220                 1225                 1230             


Phe Arg  Val Gln His His Tyr  Asn Ser His Tyr Glu  Lys Phe Gly 
    1235                 1240                 1245             


Asp Phe  Val Trp Arg Ser Glu  Asp Glu Leu Gly Pro  Arg Lys Ala 
    1250                 1255                 1260             


His Leu  Ile Leu Arg Arg Leu  Glu Arg Val Ser Ser  His Cys Ser 
    1265                 1270                 1275             


Ser Leu  Leu Arg Ser Ala Tyr  Ile Gln Ser Arg Val  Glu Thr Val 
    1280                 1285                 1290             


Pro Tyr  Leu Phe Cys Arg Ser  Glu Glu Val Arg Pro  Ala Gly Met 
    1295                 1300                 1305             


Val Trp  Tyr Ser Ile Leu Lys  Asp Thr Lys Ile Thr  Cys Glu Glu 
    1310                 1315                 1320             


Lys Met  Val Ser Met Ala Arg  Asn Thr Tyr Gly Glu  Ser Lys Gly 
    1325                 1330                 1335             


Arg 
    


<210>  7
<211>  2624
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Phe Arg Arg Ala Arg Leu Ser Val Lys Pro Asn Val Arg Pro Gly 
1               5                   10                  15      


Val Gly Ala Arg Gly Ser Thr Ala Ser Asn Pro Gln Arg Gly Arg Glu 
            20                  25                  30          


Ser Pro Arg Pro Pro Glu Pro Ala Thr Asp Ser Ala Ser Lys Pro Ala 
        35                  40                  45              


Glu Pro Thr Asp Val Pro Thr Val Asp Phe Gly Gly Ala Glu Pro Gln 
    50                  55                  60                  


Glu Lys Ala Pro Arg Ser Ser Thr Glu Lys Thr Gly Gly Asp Asn Asp 
65                  70                  75                  80  


Val Glu Glu Ser Ser Arg Ser Ser Ser Thr Val Ser Gln Arg Arg Lys 
                85                  90                  95      


Arg Ile Ser Ser Thr Ser Ser Leu Val Lys Ser Ser Val Ser Val Pro 
            100                 105                 110         


Ser Glu Ser His Pro Leu Ser Thr Ile Asn Gln Glu Ala Pro Gln Pro 
        115                 120                 125             


Thr Ala Thr Ser Thr Lys Glu Lys Gln Pro Cys Ser Asp Arg Tyr Arg 
    130                 135                 140                 


Ile Tyr Lys Ala Gln Lys Leu Arg Glu Met Leu Lys Glu Glu Leu Arg 
145                 150                 155                 160 


Lys Glu Lys Lys Gln Trp Lys Asn Lys Tyr Ala Ile Asn Glu Ser Gln 
                165                 170                 175     


Arg Pro Pro Asp Arg Ser Lys Met Thr Met Arg Asp Phe Ile Tyr Tyr 
            180                 185                 190         


Leu Pro Asp Asn Asn Pro Met Thr Ser Ser Leu Glu Gln Glu Lys Lys 
        195                 200                 205             


Thr Glu Lys Pro Ser Thr Pro Val Gln Thr Arg Glu Gln Glu Gly Lys 
    210                 215                 220                 


Ser Thr Pro Asn Ala Glu Asp Asn Glu Met Glu Glu Glu Thr Asp Asp 
225                 230                 235                 240 


Gly Pro Leu Leu Val Pro Arg Val Lys Val Ala Glu Asp Gly Ser Ile 
                245                 250                 255     


Ile Leu Asp Glu Glu Ser Leu Thr Val Glu Val Leu Arg Thr Lys Gly 
            260                 265                 270         


Pro Cys Val Val Glu Glu Asn Asp Pro Ile Phe Glu Arg Gly Ser Thr 
        275                 280                 285             


Thr Thr Tyr Ser Ser Phe Arg Lys Asn Tyr Tyr Ser Lys Pro Trp Ser 
    290                 295                 300                 


Asn Lys Glu Thr Asp Met Phe Phe Leu Ala Ile Ser Met Val Gly Thr 
305                 310                 315                 320 


Asp Phe Ser Met Ile Gly Gln Leu Phe Pro His Arg Ala Arg Ile Glu 
                325                 330                 335     


Ile Lys Asn Lys Phe Lys Arg Glu Glu Lys Thr Asn Gly Trp Arg Ile 
            340                 345                 350         


Asp Lys Ala Phe Gln Glu Lys Arg Pro Phe Asp Phe Asp Phe Phe Ala 
        355                 360                 365             


His Leu Leu Gln Lys Val Leu Ala Glu Glu Glu Lys Arg Lys Gln Lys 
    370                 375                 380                 


Ser Val Lys Asn His Ser Leu Lys Glu Lys Lys Ser Thr Lys Pro Arg 
385                 390                 395                 400 


Lys Asn Val Lys Val Lys Lys Val Ala Cys Glu Gly Val Asn Asn Asp 
                405                 410                 415     


Pro Asp Glu Ser Met Ser Ser Arg Ile Ser Asp Thr Glu Arg Ser Gln 
            420                 425                 430         


Lys Asp Ala Gln Thr Val Glu Glu Glu Ser Leu Thr Leu Ser Arg Glu 
        435                 440                 445             


Asp Ala Glu Gln Val Ala Leu Glu Val Asp Leu Asn Gln Lys Lys Arg 
    450                 455                 460                 


Arg Arg Lys Lys Gln Asp Gly Ala Asn Glu Leu Gly Val Asn Asn Leu 
465                 470                 475                 480 


Leu Glu Asn Ala Thr Val Gln Ala Gly Pro Ser Lys Gly Glu Lys His 
                485                 490                 495     


Lys Asn Lys Cys Gln Ala Ile Arg Pro Glu Leu Lys Glu Gly Glu Cys 
            500                 505                 510         


Ser Lys Glu Gln Met Leu Ser Cys Thr Gln Asn Ile Asp Gly Ile Val 
        515                 520                 525             


Gly Phe Ala Ser Thr Glu Lys Val Glu Lys Arg Thr Asp Pro Ile Leu 
    530                 535                 540                 


Ser Leu Ser Asn Gln Gln Asp Ala Thr Ser Val Ala Thr Glu Ser Ser 
545                 550                 555                 560 


Glu Ser Ser Thr Ser Asp Leu Pro Ser Phe Glu Val Gly Ile Arg Ala 
                565                 570                 575     


Leu Cys Glu Val Asn Asn Ala Glu Gly Ser Cys Ile Glu Glu Arg Asn 
            580                 585                 590         


Val Asp Leu Lys Asn Asn Ser Leu Glu Ile Asp Gln Thr Glu Asn Val 
        595                 600                 605             


Lys Pro Met Leu Arg Gly Arg Phe Gln Arg Pro Lys Pro Asn Leu Ser 
    610                 615                 620                 


Arg Ala Gly Lys Lys Ser Val Leu Ser Gln Gly Lys Thr Glu Ser Glu 
625                 630                 635                 640 


Ser Lys Asn Ser His Ser Lys Thr Ser Val Glu Lys Asn His Val Glu 
                645                 650                 655     


Lys Asp Lys Met Asn Thr Leu Asp Ile Leu Arg Met Glu Thr Thr Glu 
            660                 665                 670         


Arg Glu Asn Pro Glu Ala Glu Thr Val Ser Val Leu Gly Glu Lys Asn 
        675                 680                 685             


Cys Leu Gln Glu Gly Ser Gln Leu Lys Ala Leu Arg Pro Val Gln Val 
    690                 695                 700                 


Arg Gly Arg Leu Gln Lys Pro Lys Pro Asn Ala Gly Lys Ala Ala Glu 
705                 710                 715                 720 


Arg Lys Glu Ile Leu Ile Ser Gln Glu Glu Ile Gly Ala Asn Val Glu 
                725                 730                 735     


Lys Asn Glu Asn Glu Ser Cys Ala Asp Arg Asp Thr Pro Gln His Met 
            740                 745                 750         


Glu Asp Gln Ser Cys Lys Asp Phe Glu Glu Glu Asp Val Ile Leu Gln 
        755                 760                 765             


Pro Glu Lys Asn Asp Ser Phe Gln Asn Val Gln Pro Asp Glu Pro Lys 
    770                 775                 780                 


Val Leu Asn Glu Cys Leu Ser Val Gln Glu Asn Asn Lys Ala Asn Lys 
785                 790                 795                 800 


Leu Asn Gln Val Pro Ile Leu Arg Thr Arg Phe Gln Lys Pro Lys Pro 
                805                 810                 815     


Asn Ile Gly Arg Gly Thr Gly Arg Arg Glu Ile Ser Ser Lys Glu Glu 
            820                 825                 830         


Val Leu Glu Lys Ile Leu Val Ser Gly Glu Met Ala Ala Ala Leu Arg 
        835                 840                 845             


Glu Thr Val Arg Leu Asp Thr Ser Pro Lys Glu Met Val Pro Ala Glu 
    850                 855                 860                 


Ile Asn Thr Lys Glu Met Gln Ser Asp Leu Lys Glu Thr Gly Arg Arg 
865                 870                 875                 880 


Ala Ile Ser Pro Arg Glu Lys Ile Leu Asp Val Ile Asp Asp Thr Ile 
                885                 890                 895     


Glu Met Glu Thr Gly Leu Lys Ala Met Gly Arg Glu Ile Cys Leu Arg 
            900                 905                 910         


Glu Lys Thr Pro Glu Val Ile Asp Ala Thr Glu Glu Ile Asp Lys Asp 
        915                 920                 925             


Leu Glu Glu Ala Gly Arg Arg Glu Ile Ser Pro Gln Lys Asn Gly Pro 
    930                 935                 940                 


Glu Glu Val Lys Pro Leu Gly Glu Val Glu Thr Asp Leu Lys Ala Thr 
945                 950                 955                 960 


Gly Asn Glu Ser Ser Pro Arg Glu Lys Thr Pro Glu Val Thr Asp Ala 
                965                 970                 975     


Thr Glu Glu Ile Asp Lys Asn Leu Glu Glu Thr Gly Arg Arg Lys Ile 
            980                 985                 990         


Ser Pro Arg Glu Asn Gly Pro Glu  Glu Val Lys Pro Val  Asp Glu Met 
        995                 1000                 1005             


Glu Thr  Asp Leu Asn Ala Thr  Gly Arg Glu Ser Ser  Pro Arg Glu 
    1010                 1015                 1020             


Lys Thr  Pro Glu Val Ile Asp  Ala Thr Glu Glu Ile  Asp Leu Glu 
    1025                 1030                 1035             


Glu Thr  Glu Arg Glu Val Ser  Pro Gln Glu Asn Gly  Leu Glu Glu 
    1040                 1045                 1050             


Val Lys  Pro Leu Gly Glu Met  Glu Thr Asp Leu Lys  Ala Thr Gly 
    1055                 1060                 1065             


Arg Asp  Ser Phe Pro Arg Gly  Lys Thr Pro Glu Val  Ile Asp Ala 
    1070                 1075                 1080             


Ile Glu  Glu Ile Glu Ile Asp  Leu Glu Glu Thr Glu  Arg Glu Ile 
    1085                 1090                 1095             


Ser Pro  Gln Glu Asn Gly Leu  Glu Glu Val Lys Pro  Leu Gly Glu 
    1100                 1105                 1110             


Met Gln  Thr Asp Leu Lys Ala  Thr Gly Arg Glu Ile  Ser Pro Arg 
    1115                 1120                 1125             


Glu Lys  Thr Pro Glu Val Ile  Asp Ala Thr Glu Glu  Ile Asp Lys 
    1130                 1135                 1140             


Asp Leu  Glu Glu Thr Gly Arg  Arg Glu Ile Ser Pro  Glu Glu Asn 
    1145                 1150                 1155             


Gly Pro  Glu Glu Val Lys Pro  Val Asp Glu Met Glu  Thr Asp Leu 
    1160                 1165                 1170             


Lys Thr  Thr Gly Arg Glu Gly  Ser Ser Arg Glu Lys  Thr Arg Glu 
    1175                 1180                 1185             


Val Ile  Asp Ala Ala Glu Val  Ile Glu Thr Asp Leu  Glu Glu Thr 
    1190                 1195                 1200             


Glu Arg  Glu Ile Ser Pro Gln  Glu Asn Gly Pro Glu  Glu Val Lys 
    1205                 1210                 1215             


Pro Val  Gly Lys Met Glu Thr  Asp Leu Lys Glu Ile  Arg Glu Glu 
    1220                 1225                 1230             


Ile Ser  Gln Arg Glu Lys Val  Leu Ala Glu Phe Ser  Ala Ile Arg 
    1235                 1240                 1245             


Glu Lys  Glu Ile Asp Leu Lys  Glu Thr Gly Lys Arg  Asp Ile Pro 
    1250                 1255                 1260             


Met Met  Glu Lys Val Ser Gly  Lys Met Ala Val Val  Glu Glu Met 
    1265                 1270                 1275             


Glu Ala  Asp Leu Lys Glu Thr  Gly Lys Glu Asn Phe  Arg Glu Arg 
    1280                 1285                 1290             


Gly Ser  Glu Glu Ile Cys Val  Thr Glu Glu Lys Val  Ala Glu Leu 
    1295                 1300                 1305             


Lys Gln  Thr Gly Lys Thr Asp  Ile Ser Pro Arg Glu  Asn Glu Leu 
    1310                 1315                 1320             


Glu Glu  Thr Ser Thr Ser Arg  Gln Thr Asp Thr His  Leu Met Gln 
    1325                 1330                 1335             


Ser Gly  Ser Asn Asp Phe Ser  Ala Met Pro Ser Leu  Asp Ile Gln 
    1340                 1345                 1350             


Asn Ile  Ser Ser Glu Val Leu  Ser Met Met His Thr  Pro Val Glu 
    1355                 1360                 1365             


Glu Lys  Arg Asn Ser Glu Lys  Glu Val Ser Ser His  Phe Ser His 
    1370                 1375                 1380             


Phe Lys  Ile Ser Ser Gln Thr  His Glu Ser Asp Lys  Thr Glu Val 
    1385                 1390                 1395             


Gln Gly  Ile Gln Ser Pro Asp  Val Pro Glu Gln Phe  Ser Asp Ile 
    1400                 1405                 1410             


Asn Leu  Ser Lys Ser Leu Pro  Gln Glu Gln Lys Pro  Leu Glu Ile 
    1415                 1420                 1425             


Lys Pro  Ala Pro Phe Val Arg  Ser Arg Phe Lys Arg  Pro Lys Pro 
    1430                 1435                 1440             


Asn Leu  Ala Arg Ala Ala Leu  Lys Arg Glu Thr Thr  Glu Ser Glu 
    1445                 1450                 1455             


Lys Tyr  Ile Tyr Glu Lys Lys  Ser Glu Thr Lys Lys  Met Glu Thr 
    1460                 1465                 1470             


Ile Val  Met Gln Glu Asn Asn  Glu Gln Thr Asp Thr  Leu Pro Ser 
    1475                 1480                 1485             


Gln His  Asp Glu Ala Ser Leu  Met Ile Ser Arg Glu  Lys Asp Thr 
    1490                 1495                 1500             


Leu Gly  His Arg Asn Glu Glu  Ala Val Ile Leu Pro  Cys Thr Gln 
    1505                 1510                 1515             


Thr Glu  Arg Asn Leu Ser Pro  Ser Asn Ser Cys Glu  Pro Lys Glu 
    1520                 1525                 1530             


Glu Ser  Gln Ser Ala Pro Val  Gln Lys Asn Asp Ser  Val Val Ser 
    1535                 1540                 1545             


Val Gly  Thr Asn Asn Val Asn  Thr Phe Gln Gln Glu  Met Lys Glu 
    1550                 1555                 1560             


Ser Val  Ile Gln Thr Ala Arg  Gln Val Arg Gly Arg  Leu Gln Arg 
    1565                 1570                 1575             


Pro Arg  Pro Asn Ile Arg Lys  Thr Gly Gln Arg Gln  Ile Val Asp 
    1580                 1585                 1590             


Lys Gly  Glu Ala Lys Gly Ile  Ile Lys Glu Gly Arg  Thr Ile Leu 
    1595                 1600                 1605             


Pro Lys  Asp Glu Thr Glu Lys  Lys Val Leu Thr Val  Ser Asn Ser 
    1610                 1615                 1620             


Gln Ile  Glu Thr Glu Ile Glu  Val Pro Ser Ser Ala  Val Pro Glu 
    1625                 1630                 1635             


His Arg  Met Tyr Glu Asn Gln  Ser Gln Val Val Leu  Val Glu Asn 
    1640                 1645                 1650             


Leu His  Val Asn Lys Thr Asn  Glu Thr Ile Arg His  Glu Asn Lys 
    1655                 1660                 1665             


Pro Tyr  Val Pro Ser Ser Ala  Gln Met Thr Arg Arg  Lys Phe Gln 
    1670                 1675                 1680             


Lys Ala  Lys Pro Asn Leu Gly  Arg Ala His Ser Lys  Lys Glu Glu 
    1685                 1690                 1695             


Pro Val  Leu Glu Lys Val Thr  Thr Asp Gln Ser Lys  Glu Gly Lys 
    1700                 1705                 1710             


Pro Glu  Asp His Leu Leu Gln  Lys Gly Ala Ser Asn  Thr Gln Leu 
    1715                 1720                 1725             


Leu Leu  Lys Glu Lys Ala Glu  Leu Leu Thr Ser Leu  Glu Val Ser 
    1730                 1735                 1740             


Ala Arg  Lys Asp Cys Val Gly  Ser Lys Glu Ser Ala  Leu Ala Lys 
    1745                 1750                 1755             


Ile Asp  Ala Glu Leu Glu Glu  Val Gly Pro Ser Arg  Arg Val Gly 
    1760                 1765                 1770             


Glu Glu  Thr Val Gly Asp Asn  Ser Pro Ser Ser Val  Val Glu Glu 
    1775                 1780                 1785             


Gln Tyr  Leu Asn Lys Leu Thr  Ser Cys Pro Gln Pro  Leu Asn Glu 
    1790                 1795                 1800             


Thr Ser  Tyr Ser Lys Ile Ala  Leu Asp Gly Lys Thr  Thr Ile Ser 
    1805                 1810                 1815             


Ser Thr  Ser Glu Tyr Glu Arg  Asn Arg Gly Glu Arg  Arg Ser His 
    1820                 1825                 1830             


Lys Lys  Phe Lys Pro Asn Val  Thr Arg Gly Arg Gly  Ser Lys Arg 
    1835                 1840                 1845             


Val Arg  Gly Lys Thr Ser Lys  Lys Glu Pro Arg Ala  Ser Lys Ala 
    1850                 1855                 1860             


Met Leu  Val Thr Leu Arg Ala  Ser Gln Glu Glu Asp  Asp Asp Ala 
    1865                 1870                 1875             


Asp Asp  Phe Glu Ser Asp Tyr  Glu Glu Glu Ser Tyr  His Leu Ala 
    1880                 1885                 1890             


Pro Glu  Glu Val Asn Lys Ala  Pro Val Phe Val Pro  Val Gly Leu 
    1895                 1900                 1905             


Arg Ser  Pro Glu Pro Val Ser  Ala Gln Ile Glu Glu  Thr Met Glu 
    1910                 1915                 1920             


Glu Leu  Glu Ile Thr Val Asn  Val Pro Asp Val Gly  Cys Ile Ala 
    1925                 1930                 1935             


Val Val  Glu His Glu Leu Pro  Asn Thr Asp Val Thr  Thr Glu Glu 
    1940                 1945                 1950             


Met Lys  Gln Glu Glu Asn Leu  Ser Val Pro Phe Glu  Met Thr Thr 
    1955                 1960                 1965             


Ser Glu  His Ile Gln Asp Glu  Pro Gly Thr Asn Asp  Gly Ser Thr 
    1970                 1975                 1980             


Glu Ala  Ala Ile Thr Leu Leu  Thr Met Gly Asp Leu  Val Leu Gln 
    1985                 1990                 1995             


Ser Glu  Ile Ser Ser Glu Gln  Gly Asp Val Gly Val  Cys Ile Leu 
    2000                 2005                 2010             


Pro His  Val His Ser Lys Asp  Lys Ser His Ile Pro  Ser Ser Leu 
    2015                 2020                 2025             


Asp Asn  Val Asn His Lys Ile  Val His Glu Cys Gln  Glu Leu Ser 
    2030                 2035                 2040             


Ser Pro  Val Ile Thr Thr Ser  Pro Ala Ser Phe Glu  Glu Asn Lys 
    2045                 2050                 2055             


Ile Val  Leu Glu Glu Gln Ser  Ser Arg Glu Glu Ile  Ser Leu Met 
    2060                 2065                 2070             


Glu Lys  Val Lys Glu Asn Ala  Thr Pro Thr Arg Asn  Thr Ile Ser 
    2075                 2080                 2085             


Lys Val  Thr Ser Asn Leu Arg  Ile Arg Ser Arg Leu  Ala Lys Pro 
    2090                 2095                 2100             


Lys Pro  Asn Leu Glu Lys Thr  Leu Gly Thr Asn Arg  Leu Asp Asp 
    2105                 2110                 2115             


Tyr Gln  Glu Val Ser Ser Leu  Cys Val Thr Lys Gly  Ala Glu Met 
    2120                 2125                 2130             


Glu Thr  Gln Arg Glu Thr Glu  Lys Asn Ala Ser Lys  Ala Thr Glu 
    2135                 2140                 2145             


Leu Glu  Asn Lys Asn Leu Gly  Pro Val Thr Thr Ala  Glu Asn Lys 
    2150                 2155                 2160             


Asp Gln  Ser Lys Leu Ala Cys  Val His Gly Ile Lys  Gly Thr Ser 
    2165                 2170                 2175             


Ile Ser  Ser Glu Val Asn Leu  Thr Glu Arg Asn Glu  Asn Gln Glu 
    2180                 2185                 2190             


Glu Ser  Ser Gln Glu Val His  Met Leu Ser Val Ala  Pro Val Ala 
    2195                 2200                 2205             


Ser Ser  Glu Thr Gly Pro Cys  Thr Leu Gly Leu Asp  Arg Gly Leu 
    2210                 2215                 2220             


Gly Glu  Asn Ser Val Glu Glu  Pro Gln Ile Lys Asp  Ser Lys Gly 
    2225                 2230                 2235             


Asp Ser  Val Leu Thr Leu Pro  Val Pro Glu Tyr Thr  Pro Thr Ser 
    2240                 2245                 2250             


Ile Pro  Glu Val Gln Gln Glu  Asn Ile Ile Asn Pro  Gln Asp Leu 
    2255                 2260                 2265             


Thr Val  Asn Leu Val Ala Asn  Val Pro Gln Asp Gly  Glu Asp Glu 
    2270                 2275                 2280             


Gln Ala  Phe Ile Leu Thr Leu  Val Glu Ile Pro Ala  Asn Ala Val 
    2285                 2290                 2295             


Glu Glu  Phe Thr Asp Ala Thr  Ala Gln Phe Met Pro  Asn Pro Leu 
    2300                 2305                 2310             


Leu Pro  Ala Pro Ile Leu Val  Lys Ser Val Asn Thr  Glu Glu Arg 
    2315                 2320                 2325             


Gly Asp  Met Ser Ile Cys Leu  Pro Ala Thr Ser Val  Gly Gln Asp 
    2330                 2335                 2340             


Ala Met  Gly Leu Ser Ile Ser  Gly Arg Asp Asn Ser  Lys Lys Pro 
    2345                 2350                 2355             


Pro Asp  Asn Leu Asp Leu Val  Ser Arg Lys Arg Phe  Gln Cys Arg 
    2360                 2365                 2370             


Leu Asp  Lys Asn Asp His Ile  Pro Pro Ala Lys Lys  Arg Ser Leu 
    2375                 2380                 2385             


Thr Leu  Arg Asp Asp Cys Gln  Glu Tyr Thr Thr Glu  Val His Ser 
    2390                 2395                 2400             


Lys Glu  Leu Thr Asn Val Phe  Glu Glu Thr Gly Glu  Ser His Lys 
    2405                 2410                 2415             


Gly Gln  Asp Ile Phe Leu Thr  Ser Gly Ser Thr Leu  Thr Thr Pro 
    2420                 2425                 2430             


Glu Pro  Gln Arg Gln Gln Val  Glu Ala Ala Phe Gln  Ser Arg Gly 
    2435                 2440                 2445             


Ser Arg  Ser Pro Asp Ala Cys  Met Asp Lys Asn Val  Pro Gln Leu 
    2450                 2455                 2460             


Pro Gln  Asp Glu Met Ile Val  Ser Asp Lys Glu Glu  Arg Thr Asp 
    2465                 2470                 2475             


Ala Ala  Pro Lys Ser Gln Gln  Met Asp Ser Arg Thr  Ser Ser Ser 
    2480                 2485                 2490             


Lys Ala  Ser Leu Ser Arg Pro  Gly Arg Arg Pro Leu  Gly Phe Leu 
    2495                 2500                 2505             


Ser Leu  Ile Cys Ser Lys Asn  Ser Leu Glu Ser Asp  Glu Pro Met 
    2510                 2515                 2520             


Gln Val  His Ser Lys Lys Arg  Leu Lys Pro Leu Ile  Pro Gly Leu 
    2525                 2530                 2535             


Arg Lys  Lys Leu Lys Arg Ser  Asn Pro Phe Asn Glu  Ser Gln Glu 
    2540                 2545                 2550             


Lys Asn  Arg Glu Ser Ser Asp  Leu Leu Pro Ser Pro  Ser Val Ile 
    2555                 2560                 2565             


Thr Thr  Gln Ser Glu Asn Ile  Ser Ser Ser Ala Thr  Gln Val Ser 
    2570                 2575                 2580             


Cys Asp  Gln Pro Leu Leu Lys  Glu Gly Tyr Lys Ser  Ala Gln Lys 
    2585                 2590                 2595             


Arg Ala  Pro Gln Gly Glu Ala  Thr Thr Val Ser Glu  Tyr Phe Phe 
    2600                 2605                 2610             


Asn Asp  Ile Phe Ile Glu Val  Asp Glu Thr Glu 
    2615                 2620                 


<210>  8
<211>  1910
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Cys Cys His Lys Val Met Leu Leu Leu Asp Thr Ala Gly Gly 
1               5                   10                  15      


Ala Ala Arg His Ser Arg Val Arg Arg Ala Ala Leu Arg Leu Leu Thr 
            20                  25                  30          


Tyr Leu Ser Cys Arg Phe Gly Leu Ala Arg Val His Trp Ala Phe Lys 
        35                  40                  45              


Phe Phe Asp Ser Gln Gly Ala Arg Ser Arg Pro Ser Arg Val Ser Asp 
    50                  55                  60                  


Phe Arg Glu Leu Gly Ser Arg Ser Trp Glu Asp Phe Glu Glu Glu Leu 
65                  70                  75                  80  


Glu Ala Arg Leu Glu Asp Arg Ala His Leu Pro Gly Pro Ala Pro Arg 
                85                  90                  95      


Ala Thr His Thr His Gly Ala Leu Met Glu Thr Leu Leu Asp Tyr Gln 
            100                 105                 110         


Trp Asp Arg Pro Glu Ile Thr Ser Pro Thr Lys Pro Ile Leu Arg Ser 
        115                 120                 125             


Ser Gly Arg Arg Leu Leu Asp Val Glu Ser Glu Ala Lys Glu Ala Glu 
    130                 135                 140                 


Ala Ala Leu Gly Gly Leu Val Asn Ala Val Phe Leu Leu Ala Pro Cys 
145                 150                 155                 160 


Pro His Ser Gln Arg Glu Leu Leu Gln Phe Val Ser Gly Cys Glu Ala 
                165                 170                 175     


Gln Ala Gln Arg Leu Pro Pro Thr Pro Lys Gln Val Met Glu Lys Leu 
            180                 185                 190         


Leu Pro Lys Arg Val Arg Glu Val Met Val Ala Arg Lys Ile Thr Phe 
        195                 200                 205             


Tyr Trp Val Asp Thr Thr Glu Trp Ser Lys Leu Trp Glu Ser Pro Asp 
    210                 215                 220                 


His Leu Gly Tyr Trp Thr Val Cys Glu Leu Leu His His Gly Gly Gly 
225                 230                 235                 240 


Thr Val Leu Pro Ser Glu Ser Phe Ser Trp Asp Phe Ala Gln Ala Gly 
                245                 250                 255     


Glu Met Leu Leu Arg Ser Gly Ile Lys Leu Ser Ser Glu Pro His Leu 
            260                 265                 270         


Ser Pro Trp Ile Ser Met Leu Pro Thr Asp Ala Thr Leu Asn Arg Leu 
        275                 280                 285             


Leu Tyr Asn Ser Pro Glu Tyr Glu Ala Ser Phe Pro Arg Met Glu Gly 
    290                 295                 300                 


Met Leu Phe Leu Pro Val Glu Ala Gly Lys Glu Ile Gln Glu Thr Trp 
305                 310                 315                 320 


Thr Val Thr Leu Glu Pro Leu Ala Met His Gln Arg His Phe Gln Lys 
                325                 330                 335     


Pro Val Arg Ile Phe Leu Lys Gly Ser Val Ala Gln Trp Ser Leu Pro 
            340                 345                 350         


Thr Ser Ser Thr Leu Gly Thr Asp Ser Trp Met Leu Gly Ser Pro Glu 
        355                 360                 365             


Glu Ser Thr Ala Thr Gln Arg Leu Leu Phe Gln Gln Leu Val Ser Arg 
    370                 375                 380                 


Leu Thr Ala Glu Glu Leu His Leu Val Ala Asp Val Asp Pro Gly Glu 
385                 390                 395                 400 


Gly Arg Pro Pro Ile Thr Gly Val Ile Ser Pro Leu Ser Ala Ser Ala 
                405                 410                 415     


Met Ile Leu Thr Val Cys Arg Thr Lys Glu Ala Glu Phe Gln Arg His 
            420                 425                 430         


Val Leu Gln Thr Ala Val Ala Asp Ser Pro Arg Asp Thr Ala Ser Leu 
        435                 440                 445             


Phe Ser Asp Val Val Asp Ser Ile Leu Asn Gln Thr His Asp Ser Leu 
    450                 455                 460                 


Ala Asp Thr Ala Ser Ala Ala Ser Pro Val Pro Glu Trp Ala Gln Gln 
465                 470                 475                 480 


Glu Leu Gly His Thr Thr Pro Trp Ser Pro Ala Val Val Glu Lys Trp 
                485                 490                 495     


Phe Pro Phe Cys Asn Ile Ser Gly Ala Ser Ser Asp Leu Met Glu Ser 
            500                 505                 510         


Phe Gly Leu Leu Gln Ala Ala Ser Ala Asn Lys Glu Glu Ser Ser Lys 
        515                 520                 525             


Thr Glu Gly Glu Leu Ile His Cys Leu Ala Glu Leu Tyr Gln Arg Lys 
    530                 535                 540                 


Ser Arg Glu Glu Ser Thr Ile Ala His Gln Glu Asp Ser Lys Lys Lys 
545                 550                 555                 560 


Arg Gly Val Pro Arg Thr Pro Val Arg Gln Lys Met Asn Thr Met Cys 
                565                 570                 575     


Arg Ser Leu Lys Met Leu Asn Val Ala Arg Leu Asn Val Lys Ala Gln 
            580                 585                 590         


Lys Leu His Pro Asp Gly Ser Pro Asp Val Ala Gly Glu Lys Gly Ile 
        595                 600                 605             


Gln Lys Ile Pro Ser Gly Arg Thr Val Asp Lys Leu Glu Asp Arg Gly 
    610                 615                 620                 


Arg Thr Leu Arg Ser Ser Lys Pro Lys Asp Phe Lys Thr Glu Glu Glu 
625                 630                 635                 640 


Leu Leu Ser Tyr Ile Arg Glu Asn Tyr Gln Lys Thr Val Ala Thr Gly 
                645                 650                 655     


Glu Ile Met Leu Tyr Ala Cys Ala Arg Asn Met Ile Ser Thr Val Lys 
            660                 665                 670         


Met Phe Leu Lys Ser Lys Gly Thr Lys Glu Leu Glu Val Asn Cys Leu 
        675                 680                 685             


Asn Gln Val Lys Ser Ser Leu Leu Lys Thr Ser Lys Ser Leu Arg Gln 
    690                 695                 700                 


Asn Leu Gly Lys Lys Leu Asp Lys Glu Asp Lys Val Arg Glu Cys Gln 
705                 710                 715                 720 


Leu Gln Val Phe Leu Arg Leu Glu Met Cys Leu Gln Cys Pro Ser Ile 
                725                 730                 735     


Asn Glu Ser Thr Asp Asp Met Glu Gln Val Val Glu Glu Val Thr Asp 
            740                 745                 750         


Leu Leu Arg Met Val Cys Leu Thr Glu Asp Ser Ala Tyr Leu Ala Glu 
        755                 760                 765             


Phe Leu Glu Glu Ile Leu Arg Leu Tyr Ile Asp Ser Ile Pro Lys Thr 
    770                 775                 780                 


Leu Gly Asn Leu Tyr Asn Ser Leu Gly Phe Val Ile Pro Gln Lys Leu 
785                 790                 795                 800 


Ala Gly Val Leu Pro Thr Asp Phe Phe Ser Asp Asp Ser Met Thr Gln 
                805                 810                 815     


Glu Asn Lys Ser Pro Leu Leu Ser Val Pro Phe Leu Ser Ser Ala Arg 
            820                 825                 830         


Arg Ser Val Ser Gly Ser Pro Glu Ser Asp Glu Leu Gln Glu Leu Arg 
        835                 840                 845             


Thr Arg Ser Ala Lys Lys Arg Arg Lys Asn Ala Leu Ile Arg His Lys 
    850                 855                 860                 


Ser Ile Ala Glu Val Ser Gln Asn Leu Arg Gln Ile Glu Ile Pro Lys 
865                 870                 875                 880 


Val Ser Lys Arg Ala Thr Lys Lys Glu Asn Ser His Pro Ala Pro Gln 
                885                 890                 895     


Gln Pro Ser Gln Pro Val Lys Asp Thr Val Gln Glu Val Thr Lys Val 
            900                 905                 910         


Arg Arg Asn Leu Phe Asn Gln Glu Leu Leu Ser Pro Ser Lys Arg Ser 
        915                 920                 925             


Leu Lys Arg Gly Leu Pro Arg Ser His Ser Val Ser Ala Val Asp Gly 
    930                 935                 940                 


Leu Glu Asp Lys Leu Asp Asn Phe Lys Lys Asn Lys Gly Tyr His Lys 
945                 950                 955                 960 


Leu Leu Thr Lys Ser Val Ala Glu Thr Pro Val His Lys Gln Ile Ser 
                965                 970                 975     


Lys Arg Leu Leu His Arg Gln Ile Lys Gly Arg Ser Ser Asp Pro Gly 
            980                 985                 990         


Pro Asp Ile Gly Val Val Glu Glu  Ser Pro Glu Lys Gly  Asp Glu Ile 
        995                 1000                 1005             


Ser Leu  Arg Arg Ser Pro Arg  Ile Lys Gln Leu Ser  Phe Ser Arg 
    1010                 1015                 1020             


Thr His  Ser Ala Ser Phe Tyr  Ser Val Ser Gln Pro  Lys Ser Arg 
    1025                 1030                 1035             


Ser Val  Gln Arg Val His Ser  Phe Gln Gln Asp Lys  Ser Asp Gln 
    1040                 1045                 1050             


Arg Glu  Asn Ser Pro Val Gln  Ser Ile Arg Ser Pro  Lys Ser Leu 
    1055                 1060                 1065             


Leu Phe  Gly Ala Met Ser Glu  Met Ile Ser Pro Ser  Glu Lys Gly 
    1070                 1075                 1080             


Ser Ala  Arg Met Lys Lys Arg  Ser Arg Asn Thr Leu  Asp Ser Glu 
    1085                 1090                 1095             


Val Pro  Ala Ala Tyr Gln Thr  Pro Lys Lys Ser His  Gln Lys Ser 
    1100                 1105                 1110             


Leu Ser  Phe Ser Lys Thr Thr  Pro Arg Arg Ile Ser  His Thr Pro 
    1115                 1120                 1125             


Gln Thr  Pro Leu Tyr Thr Pro  Glu Arg Leu Gln Lys  Ser Pro Ala 
    1130                 1135                 1140             


Lys Met  Thr Pro Thr Lys Gln  Ala Ala Phe Lys Glu  Ser Leu Lys 
    1145                 1150                 1155             


Asp Ser  Ser Ser Pro Gly His  Asp Ser Pro Leu Asp  Ser Lys Ile 
    1160                 1165                 1170             


Thr Pro  Gln Lys Arg His Thr  Gln Ala Gly Glu Gly  Thr Ser Leu 
    1175                 1180                 1185             


Glu Thr  Lys Thr Pro Arg Thr  Pro Lys Arg Gln Gly  Thr Gln Pro 
    1190                 1195                 1200             


Pro Gly  Phe Leu Pro Asn Cys  Thr Trp Pro His Ser  Val Asn Ser 
    1205                 1210                 1215             


Ser Pro  Glu Ser Pro Ser Cys  Pro Ala Pro Pro Thr  Ser Ser Thr 
    1220                 1225                 1230             


Ala Gln  Pro Arg Arg Glu Cys  Leu Thr Pro Ile Arg  Asp Pro Leu 
    1235                 1240                 1245             


Arg Thr  Pro Pro Arg Ala Ala  Ala Phe Met Gly Thr  Pro Gln Asn 
    1250                 1255                 1260             


Gln Thr  His Gln Gln Pro His  Val Leu Arg Ala Ala  Arg Ala Glu 
    1265                 1270                 1275             


Glu Pro  Ala Gln Lys Leu Lys  Asp Lys Ala Ile Lys  Thr Pro Lys 
    1280                 1285                 1290             


Arg Pro  Gly Asn Ser Thr Val  Thr Ser Ser Pro Pro  Val Thr Pro 
    1295                 1300                 1305             


Lys Lys  Leu Phe Thr Ser Pro  Leu Cys Asp Val Ser  Lys Lys Ser 
    1310                 1315                 1320             


Pro Phe  Arg Lys Ser Lys Ile  Glu Cys Pro Ser Pro  Gly Glu Leu 
    1325                 1330                 1335             


Asp Gln  Lys Glu Pro Gln Met  Ser Pro Ser Val Ala  Ala Ser Leu 
    1340                 1345                 1350             


Ser Cys  Pro Val Pro Ser Thr  Pro Pro Glu Leu Ser  Gln Arg Ala 
    1355                 1360                 1365             


Thr Leu  Asp Thr Val Pro Pro  Pro Pro Pro Ser Lys  Val Gly Lys 
    1370                 1375                 1380             


Arg Cys  Arg Lys Thr Ser Asp  Pro Arg Arg Ser Ile  Val Glu Cys 
    1385                 1390                 1395             


Gln Pro  Asp Ala Ser Ala Thr  Pro Gly Val Gly Thr  Ala Asp Ser 
    1400                 1405                 1410             


Pro Ala  Ala Pro Thr Asp Ser  Arg Asp Asp Gln Lys  Gly Leu Ser 
    1415                 1420                 1425             


Leu Ser  Pro Gln Ser Pro Pro  Glu Arg Arg Gly Tyr  Pro Gly Pro 
    1430                 1435                 1440             


Gly Leu  Arg Ser Asp Trp His  Ala Ser Ser Pro Leu  Leu Ile Thr 
    1445                 1450                 1455             


Ser Asp  Thr Glu His Val Thr  Leu Leu Ser Glu Ala  Glu His His 
    1460                 1465                 1470             


Gly Ile  Gly Asp Leu Lys Ser  Asn Val Leu Ser Val  Glu Glu Gly 
    1475                 1480                 1485             


Glu Gly  Leu Arg Thr Ala Asp  Ala Glu Lys Ser Ser  Leu Ser His 
    1490                 1495                 1500             


Pro Gly  Ile Pro Pro Ser Pro  Pro Ser Cys Gly Pro  Gly Ser Pro 
    1505                 1510                 1515             


Leu Met  Pro Ser Arg Asp Val  His Cys Thr Thr Asp  Gly Arg Gln 
    1520                 1525                 1530             


Cys Gln  Ala Ser Ala Gln Leu  Asp Asn Leu Pro Ala  Ser Ala Trp 
    1535                 1540                 1545             


His Ser  Thr Asp Ser Ala Ser  Pro Gln Thr Tyr Glu  Val Glu Leu 
    1550                 1555                 1560             


Glu Met  Gln Ala Ser Gly Leu  Pro Lys Leu Arg Ile  Lys Lys Ile 
    1565                 1570                 1575             


Asp Pro  Ser Ser Ser Leu Glu  Ala Glu Pro Leu Ser  Lys Glu Glu 
    1580                 1585                 1590             


Ser Ser  Leu Gly Glu Glu Ser  Phe Leu Pro Ala Leu  Ser Met Pro 
    1595                 1600                 1605             


Arg Ala  Ser Arg Ser Leu Ser  Lys Pro Glu Pro Thr  Tyr Val Ser 
    1610                 1615                 1620             


Pro Pro  Cys Pro Arg Leu Ser  His Ser Thr Pro Gly  Lys Ser Arg 
    1625                 1630                 1635             


Gly Gln  Thr Tyr Ile Cys Gln  Ala Cys Thr Pro Thr  His Gly Pro 
    1640                 1645                 1650             


Ser Ser  Thr Pro Ser Pro Phe  Gln Thr Asp Gly Val  Pro Trp Thr 
    1655                 1660                 1665             


Pro Ser  Pro Lys His Ser Gly  Lys Thr Thr Pro Asp  Ile Ile Lys 
    1670                 1675                 1680             


Asp Trp  Pro Arg Arg Lys Arg  Ala Val Gly Cys Gly  Ala Gly Ser 
    1685                 1690                 1695             


Ser Ser  Gly Arg Gly Glu Val  Gly Ala Asp Leu Pro  Gly Ser Leu 
    1700                 1705                 1710             


Ser Leu  Leu Glu Ser Glu Gly  Lys Asp His Gly Leu  Glu Leu Ser 
    1715                 1720                 1725             


Ile His  Arg Thr Pro Ile Leu  Glu Asp Phe Glu Leu  Glu Gly Val 
    1730                 1735                 1740             


Cys Gln  Leu Pro Asp Gln Ser  Pro Pro Arg Asn Ser  Met Pro Lys 
    1745                 1750                 1755             


Ala Glu  Glu Ala Ser Ser Trp  Gly Gln Phe Gly Leu  Ser Ser Arg 
    1760                 1765                 1770             


Lys Arg  Val Leu Leu Ala Lys  Glu Glu Ala Asp Arg  Gly Ala Lys 
    1775                 1780                 1785             


Arg Ile  Cys Asp Leu Arg Glu  Asp Ser Glu Val Ser  Lys Ser Lys 
    1790                 1795                 1800             


Glu Gly  Ser Pro Ser Trp Ser  Ala Trp Gln Leu Pro  Ser Thr Gly 
    1805                 1810                 1815             


Asp Glu  Glu Val Phe Val Ser  Gly Ser Thr Pro Pro  Pro Ser Cys 
    1820                 1825                 1830             


Ala Val  Arg Ser Cys Leu Ser  Ala Ser Ala Leu Gln  Ala Leu Thr 
    1835                 1840                 1845             


Gln Ser  Pro Leu Leu Phe Gln  Gly Lys Thr Pro Ser  Ser Gln Ser 
    1850                 1855                 1860             


Lys Asp  Pro Arg Asp Glu Asp  Val Asp Val Leu Pro  Ser Thr Val 
    1865                 1870                 1875             


Glu Asp  Ser Pro Phe Ser Arg  Ala Phe Ser Arg Arg  Arg Pro Ile 
    1880                 1885                 1890             


Ser Arg  Thr Tyr Thr Arg Lys  Lys Leu Met Gly Thr  Trp Leu Glu 
    1895                 1900                 1905             


Asp Leu  
    1910 


<210>  9
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ser Asp Gly Ala Ser Ala Leu Pro Gly Pro Asp Met Ser Met 
1               5                   10                  15      


Lys Pro Ser Ala Ala Pro Ser Pro Ser Pro Ala Leu Pro Phe Leu Pro 
            20                  25                  30          


Pro Thr Ser Asp Pro Pro Asp His Pro Pro Arg Glu Pro Pro Pro Gln 
        35                  40                  45              


Pro Ile Met Pro Ser Val Phe Ser Pro Asp Asn Pro Leu Met Leu Ser 
    50                  55                  60                  


Ala Phe Pro Ser Ser Leu Leu Val Thr Gly Asp Gly Gly Pro Cys Leu 
65                  70                  75                  80  


Ser Gly Ala Gly Ala Gly Lys Val Ile Val Lys Val Lys Thr Glu Gly 
                85                  90                  95      


Gly Ser Ala Glu Pro Ser Gln Thr Gln Asn Phe Ile Leu Thr Gln Thr 
            100                 105                 110         


Ala Leu Asn Ser Thr Ala Pro Gly Thr Pro Cys Gly Gly Leu Glu Gly 
        115                 120                 125             


Pro Ala Pro Pro Phe Val Thr Ala Ser Asn Val Lys Thr Ile Leu Pro 
    130                 135                 140                 


Ser Lys Ala Val Gly Val Ser Gln Glu Gly Pro Pro Gly Leu Pro Pro 
145                 150                 155                 160 


Gln Pro Pro Pro Pro Val Ala Gln Leu Val Pro Ile Val Pro Leu Glu 
                165                 170                 175     


Lys Ala Trp Pro Gly Pro His Gly Thr Thr Gly Glu Gly Gly Pro Val 
            180                 185                 190         


Ala Thr Leu Ser Lys Pro Ser Leu Gly Asp Arg Ser Lys Ile Ser Lys 
        195                 200                 205             


Asp Val Tyr Glu Asn Phe Arg Gln Trp Gln Arg Tyr Lys Ala Leu Ala 
    210                 215                 220                 


Arg Arg His Leu Ser Gln Ser Pro Asp Thr Glu Ala Leu Ser Cys Phe 
225                 230                 235                 240 


Leu Ile Pro Val Leu Arg Ser Leu Ala Arg Leu Lys Pro Thr Met Thr 
                245                 250                 255     


Leu Glu Glu Gly Leu Pro Leu Ala Val Gln Glu Trp Glu His Thr Ser 
            260                 265                 270         


Asn Phe Asp Arg Met Ile Phe Tyr Glu Met Ala Glu Arg Phe Met Glu 
        275                 280                 285             


Phe Glu Ala Glu Glu Met Gln Ile Gln Asn Thr Gln Leu Met Asn Gly 
    290                 295                 300                 


Ser Gln Gly Leu Ser Pro Ala Thr Pro Leu Lys Leu Asp Pro Leu Gly 
305                 310                 315                 320 


Pro Leu Ala Ser Glu Val Cys Gln Gln Pro Val Tyr Ile Pro Lys Lys 
                325                 330                 335     


Ala Ala Ser Lys Thr Arg Ala Pro Arg Arg Arg Gln Arg Lys Ala Gln 
            340                 345                 350         


Arg Pro Pro Ala Pro Glu Ala Pro Lys Glu Ile Pro Pro Glu Ala Val 
        355                 360                 365             


Lys Glu Tyr Val Asp Ile Met Glu Trp Leu Val Gly Thr His Leu Ala 
    370                 375                 380                 


Thr Gly Glu Ser Asp Gly Lys Gln Glu Glu Glu Gly Gln Gln Gln Glu 
385                 390                 395                 400 


Glu Glu Gly Met Tyr Pro Asp Pro Gly Leu Leu Ser Tyr Ile Asn Glu 
                405                 410                 415     


Leu Cys Ser Gln Lys Val Phe Val Ser Lys Val Glu Ala Val Ile His 
            420                 425                 430         


Pro Gln Phe Leu Ala Asp Leu Leu Ser Pro Glu Lys Gln Arg Asp Pro 
        435                 440                 445             


Leu Ala Leu Ile Glu Glu Leu Glu Gln Glu Glu Gly Leu Thr Leu Ala 
    450                 455                 460                 


Gln Leu Val Gln Lys Arg Leu Met Ala Leu Glu Glu Glu Glu Asp Ala 
465                 470                 475                 480 


Glu Ala Pro Pro Ser Phe Ser Gly Ala Gln Leu Asp Ser Ser Pro Ser 
                485                 490                 495     


Gly Ser Val Glu Asp Glu Asp Gly Asp Gly Arg Leu Arg Pro Ser Pro 
            500                 505                 510         


Gly Leu Gln Gly Ala Gly Gly Ala Ala Cys Leu Gly Lys Val Ser Ser 
        515                 520                 525             


Ser Gly Lys Arg Ala Arg Glu Val His Gly Gly Gln Glu Gln Ala Leu 
    530                 535                 540                 


Asp Ser Pro Arg Gly Met His Arg Asp Gly Asn Thr Leu Pro Ser Pro 
545                 550                 555                 560 


Ser Ser Trp Asp Leu Gln Pro Glu Leu Ala Ala Pro Gln Gly Thr Pro 
                565                 570                 575     


Gly Pro Leu Gly Val Glu Arg Arg Gly Ser Gly Lys Val Ile Asn Gln 
            580                 585                 590         


Val Ser Leu His Gln Asp Gly His Leu Gly Gly Ala Gly Pro Pro Gly 
        595                 600                 605             


His Cys Leu Val Ala Asp Arg Thr Ser Glu Ala Leu Pro Leu Cys Trp 
    610                 615                 620                 


Gln Gly Gly Phe Gln Pro Glu Ser Thr Pro Ser Leu Asp Ala Gly Leu 
625                 630                 635                 640 


Ala Glu Leu Ala Pro Leu Gln Gly Gln Gly Leu Glu Lys Gln Val Leu 
                645                 650                 655     


Gly Leu Gln Lys Gly Gln Gln Thr Gly Gly Arg Gly Val Leu Pro Gln 
            660                 665                 670         


Gly Lys Glu Pro Leu Ala Val Pro Trp Glu Gly Ser Ser Gly Ala Met 
        675                 680                 685             


Trp Gly Asp Asp Arg Gly Thr Pro Met Ala Gln Ser Tyr Asp Gln Asn 
    690                 695                 700                 


Pro Ser Pro Arg Ala Ala Gly Glu Arg Asp Asp Val Cys Leu Ser Pro 
705                 710                 715                 720 


Gly Val Trp Leu Ser Ser Glu Met Asp Ala Val Gly Leu Glu Leu Pro 
                725                 730                 735     


Val Gln Ile Glu Glu Val Ile Glu Ser Phe Gln Val Glu Lys Cys Val 
            740                 745                 750         


Thr Glu Tyr Gln Glu Gly Cys Gln Gly Leu Gly Ser Arg Gly Asn Ile 
        755                 760                 765             


Ser Leu Gly Pro Gly Glu Thr Leu Val Pro Gly Asp Thr Glu Ser Ser 
    770                 775                 780                 


Val Ile Pro Cys Gly Gly Thr Val Ala Ala Ala Ala Leu Glu Lys Arg 
785                 790                 795                 800 


Asn Tyr Cys Ser Leu Pro Gly Pro Leu Arg Ala Asn Ser Pro Pro Leu 
                805                 810                 815     


Arg Ser Lys Glu Asn Gln Glu Gln Ser Cys Glu Thr Val Gly His Pro 
            820                 825                 830         


Ser Asp Leu Trp Ala Glu Gly Cys Phe Pro Leu Leu Glu Ser Gly Asp 
        835                 840                 845             


Ser Thr Leu Gly Ser Ser Lys Glu Thr Leu Pro Pro Thr Cys Gln Gly 
    850                 855                 860                 


Asn Leu Leu Ile Met Gly Thr Glu Asp Ala Ser Ser Leu Pro Glu Ala 
865                 870                 875                 880 


Ser Gln Glu Ala Gly Ser Arg Gly Asn Ser Phe Ser Pro Leu Leu Glu 
                885                 890                 895     


Thr Ile Glu Pro Val Asn Ile Leu Asp Val Lys Asp Asp Cys Gly Leu 
            900                 905                 910         


Gln Leu Arg Val Ser Glu Asp Thr Cys Pro Leu Asn Val His Ser Tyr 
        915                 920                 925             


Asp Pro Gln Gly Glu Gly Arg Val Asp Pro Asp Leu Ser Lys Pro Lys 
    930                 935                 940                 


Asn Leu Ala Pro Leu Gln Glu Ser Gln Glu Ser Tyr Thr Thr Gly Thr 
945                 950                 955                 960 


Pro Lys Ala Thr Ser Ser His Gln Gly Leu Gly Ser Thr Leu Pro Arg 
                965                 970                 975     


Arg Gly Thr Arg Asn Ala Ile Val Pro Arg Glu Thr Ser Val Ser Lys 
            980                 985                 990         


Thr His Arg Ser Ala Asp Arg Ala  Lys Gly Lys Glu Lys  Lys Lys Lys 
        995                 1000                 1005             


Glu Ala  Glu Glu Glu Asp Glu  Glu Leu Ser Asn Phe  Ala Tyr Leu 
    1010                 1015                 1020             


Leu Ala  Ser Lys Leu Ser Leu  Ser Pro Arg Glu His  Pro Leu Ser 
    1025                 1030                 1035             


Pro His  His Ala Ser Gly Gly  Gln Gly Ser Gln Arg  Ala Ser His 
    1040                 1045                 1050             


Leu Leu  Pro Ala Gly Ala Lys  Gly Pro Ser Lys Leu  Pro Tyr Pro 
    1055                 1060                 1065             


Val Ala  Lys Ser Gly Lys Arg  Ala Leu Ala Gly Gly  Pro Ala Pro 
    1070                 1075                 1080             


Thr Glu  Lys Thr Pro His Ser  Gly Ala Gln Leu Gly  Val Pro Arg 
    1085                 1090                 1095             


Glu Lys  Pro Leu Ala Leu Gly  Val Val Arg Pro Ser  Gln Pro Arg 
    1100                 1105                 1110             


Lys Arg  Arg Cys Asp Ser Phe  Val Thr Gly Arg Arg  Lys Lys Arg 
    1115                 1120                 1125             


Arg Arg  Ser Gln 
    1130         


<210>  10
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Pro Gln Asp Pro Ala Leu Tyr Pro Gln Ala Pro His Pro Leu 
1               5                   10                  15      


Ala Leu Gly Arg Ala Ser His Pro Ser Gln Ser Arg Asn Thr Pro Pro 
            20                  25                  30          


Ala Gly Arg Pro Arg Ala Ala Ala Arg Cys Gly Pro Glu Arg Arg Ala 
        35                  40                  45              


Pro Ile Gly Gln Ser Gly Arg Gly Arg Glu Lys Trp Pro Thr Ala Ala 
    50                  55                  60                  


Ser Ala Leu Gly Leu Leu Arg Arg Trp Arg Arg Ala Ser Lys Ala Ser 
65                  70                  75                  80  


Val Pro Ala Asp Ser Phe Arg Thr Ile Ser Pro Asp Arg Arg Gly Glu 
                85                  90                  95      


Lys Ser Ala Ser Ala Val Ser Gly Asp Thr Ala Ala Ala Thr Thr Leu 
            100                 105                 110         


Lys Gly Thr Ala Ile Pro Val Arg Ser Val Val Ala Ser Pro Arg Pro 
        115                 120                 125             


Val Lys Gly Lys Ala Gly Arg Glu Thr Ala Arg Leu Arg Leu Gln Arg 
    130                 135                 140                 


Leu Pro Ala Ala Gln Ala Glu Asp Thr Gly Glu Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Ala Glu Glu Pro Leu Leu Pro Val Pro Glu Asp Glu Glu Glu Ala Gln 
                165                 170                 175     


Pro Leu Pro Pro Val Cys Val Ser Arg Met Arg Gly Met Trp Arg Asp 
            180                 185                 190         


Glu Lys Val Ser Leu Tyr Cys Asp Glu Val Leu Gln Asp Cys Lys Ala 
        195                 200                 205             


Glu Asp Ala Asp Glu Val Met Gly Lys Tyr Leu Ser Glu Lys Leu Lys 
    210                 215                 220                 


Leu Lys Asp Lys Trp Leu Gly Val Trp Lys Thr Asn Pro Ser Val Phe 
225                 230                 235                 240 


Phe Val Lys Tyr Glu Glu Ala Ser Ile Pro Phe Val Gly Ile Leu Val 
                245                 250                 255     


Glu Val Thr Cys Glu Pro Tyr Gln Asp Ser Ser Ser Arg Phe Lys Val 
            260                 265                 270         


Thr Val Ser Val Ala Glu Pro Phe Ser Ser Asn Ile Ala Asn Ile Pro 
        275                 280                 285             


Arg Asp Leu Val Asp Glu Ile Leu Glu Glu Leu Glu His Ser Val Pro 
    290                 295                 300                 


Leu Leu Glu Val Tyr Pro Val Glu Gly Gln Asp Thr Asp Ile His Val 
305                 310                 315                 320 


Ile Ala Leu Ala Leu Glu Val Val Arg Phe Phe Tyr Asp Phe Leu Trp 
                325                 330                 335     


Arg Asp Trp Asp Asp Glu Glu Ser Cys Glu Asn Tyr Thr Ala Leu Ile 
            340                 345                 350         


Glu Glu Arg Ile Asn Leu Trp Cys Asp Ile Gln Asp Gly Thr Ile Pro 
        355                 360                 365             


Gly Pro Ile Ala Gln Arg Phe Lys Lys Thr Leu Glu Lys Tyr Lys Asn 
    370                 375                 380                 


Lys Arg Val Glu Leu Ile Glu Tyr Gln Ser Asn Ile Lys Glu Asp Pro 
385                 390                 395                 400 


Ser Ala Ala Glu Ala Val Glu Cys Trp Lys Lys Tyr Tyr Glu Ile Val 
                405                 410                 415     


Met Leu Cys Gly Leu Leu Lys Met Trp Glu Asp Leu Arg Leu Arg Val 
            420                 425                 430         


His Gly Pro Phe Phe Pro Arg Ile Leu Arg Arg Arg Lys Gly Lys Arg 
        435                 440                 445             


Glu Phe Gly Lys Thr Ile Thr His Ile Val Ala Lys Met Met Thr Thr 
    450                 455                 460                 


Glu Met Ile Lys Asp Leu Ser Ser Asp Thr Leu Leu Gln Gln His Gly 
465                 470                 475                 480 


Asp Leu Asp Leu Ala Leu Asp Asn Cys Tyr Ser Gly Asp Thr Val Ile 
                485                 490                 495     


Ile Phe Pro Gly Glu Tyr Gln Ala Ala Asn Leu Ala Leu Leu Thr Asp 
            500                 505                 510         


Asp Ile Ile Ile Lys Gly Val Gly Lys Arg Glu Glu Ile Met Ile Thr 
        515                 520                 525             


Ser Glu Pro Ser Arg Asp Ser Phe Val Val Ser Lys Ala Asp Asn Val 
    530                 535                 540                 


Lys Leu Met His Leu Ser Leu Ile Gln Gln Gly Thr Val Asp Gly Ile 
545                 550                 555                 560 


Val Val Val Glu Ser Gly His Met Thr Leu Glu Asn Cys Ile Leu Lys 
                565                 570                 575     


Cys Glu Gly Thr Gly Val Cys Val Leu Thr Gly Ala Ala Leu Thr Ile 
            580                 585                 590         


Thr Asp Ser Glu Ile Thr Gly Ala Gln Gly Ala Gly Val Glu Leu Tyr 
        595                 600                 605             


Pro Gly Ser Ile Ala Ile Leu Glu Arg Asn Glu Ile His His Cys Asn 
    610                 615                 620                 


Asn Leu Arg Thr Ser Asn Ser Ser Lys Ser Thr Leu Gly Gly Val Asn 
625                 630                 635                 640 


Met Lys Val Leu Pro Ala Pro Lys Leu Lys Met Thr Asn Asn His Ile 
                645                 650                 655     


Tyr Ser Asn Lys Gly Tyr Gly Val Ser Ile Leu Gln Pro Met Glu Gln 
            660                 665                 670         


Phe Phe Ile Val Ala Glu Glu Ala Leu Asn Lys Arg Ala Ser Ser Gly 
        675                 680                 685             


Asp Lys Lys Asp Asp Lys Met Leu Phe Lys Val Met Gln Asn Leu Asn 
    690                 695                 700                 


Leu Glu Met Asn Asn Asn Lys Ile Glu Ala Asn Val Lys Gly Asp Ile 
705                 710                 715                 720 


Arg Ile Val Thr Ser 
                725 


<210>  11
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Glu Ala Asp Gly Leu Arg Gln Arg Arg Pro Leu Arg Pro Gln 
1               5                   10                  15      


Val Val Thr Asp Asp Asp Gly Gln Ala Pro Glu Ala Lys Asp Gly Ser 
            20                  25                  30          


Ser Phe Ser Gly Arg Val Phe Arg Val Thr Phe Leu Met Leu Ala Val 
        35                  40                  45              


Ser Leu Thr Val Pro Leu Leu Gly Ala Met Met Leu Leu Glu Ser Pro 
    50                  55                  60                  


Ile Asp Pro Gln Pro Leu Ser Phe Lys Glu Pro Pro Leu Leu Leu Gly 
65                  70                  75                  80  


Val Leu His Pro Asn Thr Lys Leu Arg Gln Ala Glu Arg Leu Phe Glu 
                85                  90                  95      


Asn Gln Leu Val Gly Pro Glu Ser Ile Ala His Ile Gly Asp Val Met 
            100                 105                 110         


Phe Thr Gly Thr Ala Asp Gly Arg Val Val Lys Leu Glu Asn Gly Glu 
        115                 120                 125             


Ile Glu Thr Ile Ala Arg Phe Gly Ser Gly Pro Cys Lys Thr Arg Asp 
    130                 135                 140                 


Asp Glu Pro Val Cys Gly Arg Pro Leu Gly Ile Arg Ala Gly Pro Asn 
145                 150                 155                 160 


Gly Thr Leu Phe Val Ala Asp Ala Tyr Lys Gly Leu Phe Glu Val Asn 
                165                 170                 175     


Pro Trp Lys Arg Glu Val Lys Leu Leu Leu Ser Ser Glu Thr Pro Ile 
            180                 185                 190         


Glu Gly Lys Asn Met Ser Phe Val Asn Asp Leu Thr Val Thr Gln Asp 
        195                 200                 205             


Gly Arg Lys Ile Tyr Phe Thr Asp Ser Ser Ser Lys Trp Gln Arg Arg 
    210                 215                 220                 


Asp Tyr Leu Leu Leu Val Met Glu Gly Thr Asp Asp Gly Arg Leu Leu 
225                 230                 235                 240 


Glu Tyr Asp Thr Val Thr Arg Glu Val Lys Val Leu Leu Asp Gln Leu 
                245                 250                 255     


Arg Phe Pro Asn Gly Val Gln Leu Ser Pro Ala Glu Asp Phe Val Leu 
            260                 265                 270         


Val Ala Glu Thr Thr Met Ala Arg Ile Arg Arg Val Tyr Val Ser Gly 
        275                 280                 285             


Leu Met Lys Gly Gly Ala Asp Leu Phe Val Glu Asn Met Pro Gly Phe 
    290                 295                 300                 


Pro Asp Asn Ile Arg Pro Ser Ser Ser Gly Gly Tyr Trp Val Gly Met 
305                 310                 315                 320 


Ser Thr Ile Arg Pro Asn Pro Gly Phe Ser Met Leu Asp Phe Leu Ser 
                325                 330                 335     


Glu Arg Pro Trp Ile Lys Arg Met Ile Phe Lys Leu Phe Ser Gln Glu 
            340                 345                 350         


Thr Val Met Lys Phe Val Pro Arg Tyr Ser Leu Val Leu Glu Leu Ser 
        355                 360                 365             


Asp Ser Gly Ala Phe Arg Arg Ser Leu His Asp Pro Asp Gly Leu Val 
    370                 375                 380                 


Ala Thr Tyr Ile Ser Glu Val His Glu His Asp Gly His Leu Tyr Leu 
385                 390                 395                 400 


Gly Ser Phe Arg Ser Pro Phe Leu Cys Arg Leu Ser Leu Gln Ala Val 
                405                 410                 415     


<210>  12
<211>  1142
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Glu Pro Gly Gly Ala Ala Gly Arg Ser His Pro Glu Asp Gly 
1               5                   10                  15      


Ser Ala Ser Glu Gly Glu Lys Glu Gly Asn Asn Glu Ser His Met Val 
            20                  25                  30          


Ser Pro Pro Glu Lys Asp Asp Gly Gln Lys Gly Glu Glu Ala Val Gly 
        35                  40                  45              


Ser Thr Glu His Pro Glu Glu Val Thr Thr Gln Ala Glu Ala Ala Ile 
    50                  55                  60                  


Glu Glu Gly Glu Val Glu Thr Glu Gly Glu Ala Ala Val Glu Gly Glu 
65                  70                  75                  80  


Glu Glu Ala Val Ser Tyr Gly Asp Ala Glu Ser Glu Glu Glu Tyr Tyr 
                85                  90                  95      


Tyr Thr Glu Thr Ser Ser Pro Glu Gly Gln Ile Ser Ala Ala Asp Thr 
            100                 105                 110         


Thr Tyr Pro Tyr Phe Ser Pro Pro Gln Glu Leu Pro Gly Glu Glu Ala 
        115                 120                 125             


Tyr Asp Ser Val Ser Gly Glu Ala Gly Leu Gln Gly Phe Gln Gln Glu 
    130                 135                 140                 


Ala Thr Gly Pro Pro Glu Ser Arg Glu Arg Arg Val Thr Ser Pro Glu 
145                 150                 155                 160 


Pro Ser His Gly Val Leu Gly Pro Ser Glu Gln Met Gly Gln Val Thr 
                165                 170                 175     


Ser Gly Pro Ala Val Gly Arg Leu Thr Gly Ser Thr Glu Glu Pro Gln 
            180                 185                 190         


Gly Gln Val Leu Pro Met Gly Val Gln His Arg Phe Arg Leu Ser His 
        195                 200                 205             


Gly Ser Asp Ile Glu Ser Ser Asp Leu Glu Glu Phe Val Ser Gln Glu 
    210                 215                 220                 


Pro Val Ile Pro Pro Gly Val Pro Asp Ala His Pro Arg Glu Gly Asp 
225                 230                 235                 240 


Leu Pro Val Phe Gln Asp Gln Ile Gln Gln Pro Ser Thr Glu Glu Gly 
                245                 250                 255     


Ala Met Ala Glu Arg Val Glu Ser Glu Gly Ser Asp Glu Glu Ala Glu 
            260                 265                 270         


Asp Glu Gly Ser Gln Leu Val Val Leu Asp Pro Asp His Pro Leu Met 
        275                 280                 285             


Val Arg Phe Gln Ala Ala Leu Lys Asn Tyr Leu Asn Arg Gln Ile Glu 
    290                 295                 300                 


Lys Leu Lys Leu Asp Leu Gln Glu Leu Val Val Ala Thr Lys Gln Ser 
305                 310                 315                 320 


Arg Ala Gln Arg Gln Glu Leu Gly Val Asn Leu Tyr Glu Val Gln Gln 
                325                 330                 335     


His Leu Val His Leu Gln Lys Leu Leu Glu Lys Ser His Asp Arg His 
            340                 345                 350         


Ala Met Ala Ser Ser Glu Arg Arg Gln Lys Glu Glu Glu Leu Gln Ala 
        355                 360                 365             


Ala Arg Ala Leu Tyr Thr Lys Thr Cys Ala Ala Ala Asn Glu Glu Arg 
    370                 375                 380                 


Lys Lys Leu Ala Ala Leu Gln Thr Glu Met Glu Asn Leu Ala Leu His 
385                 390                 395                 400 


Leu Phe Tyr Met Gln Asn Ile Asp Gln Asp Met Arg Asp Asp Ile Arg 
                405                 410                 415     


Val Met Thr Gln Val Val Lys Lys Ala Glu Thr Glu Arg Ile Arg Ala 
            420                 425                 430         


Glu Ile Glu Lys Lys Lys Gln Asp Leu Tyr Val Asp Gln Leu Thr Thr 
        435                 440                 445             


Arg Ala Gln Gln Leu Glu Glu Asp Ile Ala Leu Phe Glu Ala Gln Tyr 
    450                 455                 460                 


Leu Ala Gln Ala Glu Asp Thr Arg Ile Leu Arg Lys Ala Val Ser Glu 
465                 470                 475                 480 


Ala Cys Thr Glu Ile Asp Ala Ile Ser Val Glu Lys Arg Arg Ile Met 
                485                 490                 495     


Gln Gln Trp Ala Ser Ser Leu Val Gly Met Lys His Arg Asp Glu Ala 
            500                 505                 510         


His Arg Ala Val Leu Glu Ala Leu Arg Gly Cys Gln His Gln Ala Lys 
        515                 520                 525             


Ser Thr Asp Gly Glu Ile Glu Ala Tyr Lys Lys Ser Ile Met Lys Glu 
    530                 535                 540                 


Glu Glu Lys Asn Glu Lys Leu Ala Ser Ile Leu Asn Arg Thr Glu Thr 
545                 550                 555                 560 


Glu Ala Thr Leu Leu Gln Lys Leu Thr Thr Gln Cys Leu Thr Lys Gln 
                565                 570                 575     


Val Ala Leu Gln Ser Gln Phe Asn Thr Tyr Arg Leu Thr Leu Gln Asp 
            580                 585                 590         


Thr Glu Asp Ala Leu Ser Gln Asp Gln Leu Glu Gln Met Ile Leu Thr 
        595                 600                 605             


Glu Glu Leu Gln Ala Ile Arg Gln Ala Ile Gln Gly Glu Leu Glu Leu 
    610                 615                 620                 


Arg Arg Lys Thr Asp Ala Ala Ile Arg Glu Lys Leu Gln Glu His Met 
625                 630                 635                 640 


Thr Ser Asn Lys Thr Thr Lys Tyr Phe Asn Gln Leu Ile Leu Arg Leu 
                645                 650                 655     


Gln Lys Glu Lys Thr Asn Met Met Thr His Leu Ser Lys Ile Asn Gly 
            660                 665                 670         


Asp Ile Ala Gln Thr Thr Leu Asp Ile Thr His Thr Ser Ser Arg Leu 
        675                 680                 685             


Asp Ala His Gln Lys Thr Leu Val Glu Leu Asp Gln Asp Val Lys Lys 
    690                 695                 700                 


Val Asn Glu Leu Ile Thr Asn Ser Gln Ser Glu Ile Ser Arg Arg Thr 
705                 710                 715                 720 


Ile Leu Ile Glu Arg Lys Gln Gly Leu Ile Asn Phe Leu Asn Lys Gln 
                725                 730                 735     


Leu Glu Arg Met Val Ser Glu Leu Gly Gly Glu Glu Val Gly Pro Leu 
            740                 745                 750         


Glu Leu Glu Ile Lys Arg Leu Ser Lys Leu Ile Asp Glu His Asp Gly 
        755                 760                 765             


Lys Ala Val Gln Ala Gln Val Thr Trp Leu Arg Leu Gln Gln Glu Met 
    770                 775                 780                 


Val Lys Val Thr Gln Glu Gln Glu Glu Gln Leu Ala Ser Leu Asp Ala 
785                 790                 795                 800 


Ser Lys Lys Glu Leu His Ile Met Glu Gln Lys Lys Leu Arg Val Glu 
                805                 810                 815     


Ser Lys Ile Glu Gln Glu Lys Lys Glu Gln Lys Glu Ile Glu His His 
            820                 825                 830         


Met Lys Asp Leu Asp Asn Asp Leu Lys Lys Leu Asn Met Leu Met Asn 
        835                 840                 845             


Lys Asn Arg Cys Ser Ser Glu Glu Leu Glu Gln Asn Asn Arg Val Thr 
    850                 855                 860                 


Glu Asn Glu Phe Val Arg Ser Leu Lys Ala Ser Glu Arg Glu Thr Ile 
865                 870                 875                 880 


Lys Met Gln Asp Lys Leu Asn Gln Leu Ser Glu Glu Lys Ala Thr Leu 
                885                 890                 895     


Leu Asn Gln Leu Val Glu Ala Glu His Gln Ile Met Leu Trp Glu Lys 
            900                 905                 910         


Lys Ile Gln Leu Ala Lys Glu Met Arg Ser Ser Val Asp Ser Glu Ile 
        915                 920                 925             


Gly Gln Thr Glu Ile Arg Ala Met Lys Gly Glu Ile His Arg Met Lys 
    930                 935                 940                 


Val Arg Leu Gly Gln Leu Leu Lys Gln Gln Glu Lys Met Ile Arg Ala 
945                 950                 955                 960 


Met Glu Leu Ala Val Ala Arg Arg Glu Thr Val Thr Thr Gln Ala Glu 
                965                 970                 975     


Gly Gln Arg Lys Met Asp Arg Lys Ala Leu Thr Arg Thr Asp Phe His 
            980                 985                 990         


His Lys Gln Leu Glu Leu Arg Arg  Lys Ile Arg Asp Val  Arg Lys Ala 
        995                 1000                 1005             


Thr Asp  Glu Cys Thr Lys Thr  Val Leu Glu Leu Glu  Glu Thr Gln 
    1010                 1015                 1020             


Arg Asn  Val Ser Ser Ser Leu  Leu Glu Lys Gln Glu  Lys Leu Ser 
    1025                 1030                 1035             


Val Ile  Gln Ala Asp Phe Asp  Thr Leu Glu Ala Asp  Leu Thr Arg 
    1040                 1045                 1050             


Leu Gly  Ala Leu Lys Arg Gln  Asn Leu Ser Glu Ile  Val Ala Leu 
    1055                 1060                 1065             


Gln Thr  Arg Leu Lys His Leu  Gln Ala Val Lys Glu  Gly Arg Tyr 
    1070                 1075                 1080             


Val Phe  Leu Phe Arg Ser Lys  Gln Ser Leu Val Leu  Glu Arg Gln 
    1085                 1090                 1095             


Arg Leu  Asp Lys Arg Leu Ala  Leu Ile Ala Thr Ile  Leu Asp Arg 
    1100                 1105                 1110             


Val Arg  Asp Glu Tyr Pro Gln  Phe Gln Glu Ala Leu  His Lys Val 
    1115                 1120                 1125             


Ser Gln  Met Ile Ala Asn Lys  Leu Glu Ser Pro Gly  Pro Ser 
    1130                 1135                 1140         


<210>  13
<211>  1754
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Pro Tyr Pro Cys Gly Cys His Ile Leu Leu Leu Leu Phe Cys 
1               5                   10                  15      


Cys Leu Ala Ala Ala Arg Ala Asn Leu Leu Asn Leu Asn Trp Leu Trp 
            20                  25                  30          


Phe Asn Asn Glu Asp Thr Ser His Ala Ala Thr Thr Ile Pro Glu Pro 
        35                  40                  45              


Gln Gly Pro Leu Pro Val Gln Pro Thr Ala Asp Thr Thr Thr His Val 
    50                  55                  60                  


Thr Pro Arg Asn Gly Ser Thr Glu Pro Ala Thr Ala Pro Gly Ser Pro 
65                  70                  75                  80  


Glu Pro Pro Ser Glu Leu Leu Glu Asp Gly Gln Asp Thr Pro Thr Ser 
                85                  90                  95      


Ala Glu Ser Pro Asp Ala Pro Glu Glu Asn Ile Ala Gly Val Gly Ala 
            100                 105                 110         


Glu Ile Leu Asn Val Ala Lys Gly Ile Arg Ser Phe Val Gln Leu Trp 
        115                 120                 125             


Asn Asp Thr Val Pro Thr Glu Ser Leu Ala Arg Ala Glu Thr Leu Val 
    130                 135                 140                 


Leu Glu Thr Pro Val Gly Pro Leu Ala Leu Ala Gly Pro Ser Ser Thr 
145                 150                 155                 160 


Pro Gln Glu Asn Gly Thr Thr Leu Trp Pro Ser Arg Gly Ile Pro Ser 
                165                 170                 175     


Ser Pro Gly Ala His Thr Thr Glu Ala Gly Thr Leu Pro Ala Pro Thr 
            180                 185                 190         


Pro Ser Pro Pro Ser Leu Gly Arg Pro Trp Ala Pro Leu Thr Gly Pro 
        195                 200                 205             


Ser Val Pro Pro Pro Ser Ser Gly Arg Ala Ser Leu Ser Ser Leu Leu 
    210                 215                 220                 


Gly Gly Ala Pro Pro Trp Gly Ser Leu Gln Asp Pro Asp Ser Gln Gly 
225                 230                 235                 240 


Leu Ser Pro Ala Ala Ala Ala Pro Ser Gln Gln Leu Gln Arg Pro Asp 
                245                 250                 255     


Val Arg Leu Arg Thr Pro Leu Leu His Pro Leu Val Met Gly Ser Leu 
            260                 265                 270         


Gly Lys His Ala Ala Pro Ser Ala Phe Ser Ser Gly Leu Pro Gly Ala 
        275                 280                 285             


Leu Ser Gln Val Ala Val Thr Thr Leu Thr Arg Asp Ser Gly Ala Trp 
    290                 295                 300                 


Val Ser His Val Ala Asn Ser Val Gly Pro Gly Leu Ala Asn Asn Ser 
305                 310                 315                 320 


Ala Leu Leu Gly Ala Asp Pro Glu Ala Pro Ala Gly Arg Cys Leu Pro 
                325                 330                 335     


Leu Pro Pro Ser Leu Pro Val Cys Gly His Leu Gly Ile Ser Arg Phe 
            340                 345                 350         


Trp Leu Pro Asn His Leu His His Glu Ser Gly Glu Gln Val Arg Ala 
        355                 360                 365             


Gly Ala Arg Ala Trp Gly Gly Leu Leu Gln Thr His Cys His Pro Phe 
    370                 375                 380                 


Leu Ala Trp Phe Phe Cys Leu Leu Leu Val Pro Pro Cys Gly Ser Val 
385                 390                 395                 400 


Pro Pro Pro Ala Pro Pro Pro Cys Cys Gln Phe Cys Glu Ala Leu Gln 
                405                 410                 415     


Asp Ala Cys Trp Ser Arg Leu Gly Gly Gly Arg Leu Pro Val Ala Cys 
            420                 425                 430         


Ala Ser Leu Pro Thr Gln Glu Asp Gly Tyr Cys Val Leu Ile Gly Pro 
        435                 440                 445             


Ala Ala Glu Arg Ile Ser Glu Glu Val Gly Leu Leu Gln Leu Leu Gly 
    450                 455                 460                 


Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp Asp Pro Asp Val Gly 
465                 470                 475                 480 


Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser Gly Gln Val Ala Arg 
                485                 490                 495     


Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe Ser Leu Leu Phe His 
            500                 505                 510         


Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu Phe Ala Ile Thr Asp 
        515                 520                 525             


Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys Leu Ser Gly Val Gln 
    530                 535                 540                 


Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr Glu Pro Gly Ala Gly 
545                 550                 555                 560 


Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro Ala Phe Val Gly Gln 
                565                 570                 575     


Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly Phe Val Ala Leu Tyr 
            580                 585                 590         


Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu Ala Arg Ser Ser Arg 
        595                 600                 605             


Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe Val Ala Gln Ala Gly 
    610                 615                 620                 


Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile Ala Glu Leu Lys Val 
625                 630                 635                 640 


Arg Arg Asp Pro Gln Val Ser Pro Met His Cys Leu Asp Glu Glu Gly 
                645                 650                 655     


Asp Asp Ser Asp Gly Ala Ser Gly Asp Ser Gly Ser Gly Leu Gly Asp 
            660                 665                 670         


Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala Ala Leu Lys Pro Arg 
        675                 680                 685             


Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro Leu Ala Gly Gly Ser 
    690                 695                 700                 


Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu Glu Gln Thr Thr Val 
705                 710                 715                 720 


Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser Asp Ser Val Ser Thr 
                725                 730                 735     


Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg Val Lys Glu Gly Gly 
            740                 745                 750         


Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro Gly Pro Pro Gly Arg 
        755                 760                 765             


Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly Pro Pro Gly Leu Pro 
    770                 775                 780                 


Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro Ala Leu Gln Thr Val 
785                 790                 795                 800 


Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Arg Asp Gly Thr Pro 
                805                 810                 815     


Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu Asp Gly Lys Pro Gly 
            820                 825                 830         


Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro Gly Asp Val Gly Pro 
        835                 840                 845             


Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu Arg Gly Pro Pro Gly 
    850                 855                 860                 


Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser Phe Arg His Asp Lys 
865                 870                 875                 880 


Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe Gly Gly Asp Leu Glu 
                885                 890                 895     


Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro Pro Gly Pro Pro Gly 
            900                 905                 910         


Val Pro Gly Leu Pro Gly Glu Pro Gly Arg Phe Gly Val Asn Ser Ser 
        915                 920                 925             


Asp Val Pro Gly Pro Ala Gly Leu Pro Gly Val Pro Gly Arg Glu Gly 
    930                 935                 940                 


Pro Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Arg 
945                 950                 955                 960 


Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly Ser Leu Gly Glu Ala 
                965                 970                 975     


Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala Pro Gly Pro Ala Gly 
            980                 985                 990         


Ala Arg Gly Glu Ser Gly Leu Ala  Gly Ala Pro Gly Pro  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Gly Leu Pro 
    1010                 1015                 1020             


Ala Gly  Phe Asp Asp Met Glu  Gly Ser Gly Gly Pro  Phe Trp Ser 
    1025                 1030                 1035             


Thr Ala  Arg Ser Ala Asp Gly  Pro Gln Gly Pro Pro  Gly Leu Pro 
    1040                 1045                 1050             


Gly Leu  Lys Gly Asp Pro Gly  Val Pro Gly Leu Pro  Gly Ala Lys 
    1055                 1060                 1065             


Gly Glu  Val Gly Ala Asp Gly  Val Pro Gly Phe Pro  Gly Leu Pro 
    1070                 1075                 1080             


Gly Arg  Glu Gly Ile Ala Gly  Pro Gln Gly Pro Lys  Gly Asp Arg 
    1085                 1090                 1095             


Gly Ser  Arg Gly Glu Lys Gly  Asp Pro Gly Lys Asp  Gly Val Gly 
    1100                 1105                 1110             


Gln Pro  Gly Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Val Val 
    1115                 1120                 1125             


Tyr Val  Ser Glu Gln Asp Gly  Ser Val Leu Ser Val  Pro Gly Pro 
    1130                 1135                 1140             


Glu Gly  Arg Pro Gly Phe Ala  Gly Phe Pro Gly Pro  Ala Gly Pro 
    1145                 1150                 1155             


Lys Gly  Asn Leu Gly Ser Lys  Gly Glu Arg Gly Ser  Pro Gly Pro 
    1160                 1165                 1170             


Lys Gly  Glu Lys Gly Glu Pro  Gly Ser Ile Phe Ser  Pro Asp Gly 
    1175                 1180                 1185             


Gly Ala  Leu Gly Pro Ala Gln  Lys Gly Ala Lys Gly  Glu Pro Gly 
    1190                 1195                 1200             


Phe Arg  Gly Pro Pro Gly Pro  Tyr Gly Arg Pro Gly  Tyr Lys Gly 
    1205                 1210                 1215             


Glu Ile  Gly Phe Pro Gly Arg  Pro Gly Arg Pro Gly  Met Asn Gly 
    1220                 1225                 1230             


Leu Lys  Gly Glu Lys Gly Glu  Pro Gly Asp Ala Ser  Leu Gly Phe 
    1235                 1240                 1245             


Gly Met  Arg Gly Met Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1250                 1255                 1260             


Gly Pro  Pro Gly Thr Pro Val  Tyr Asp Ser Asn Val  Phe Ala Glu 
    1265                 1270                 1275             


Ser Ser  Arg Pro Gly Pro Pro  Gly Leu Pro Gly Asn  Gln Gly Pro 
    1280                 1285                 1290             


Pro Gly  Pro Lys Gly Ala Lys  Gly Glu Val Gly Pro  Pro Gly Pro 
    1295                 1300                 1305             


Pro Gly  Gln Phe Pro Phe Asp  Phe Leu Gln Leu Glu  Ala Glu Met 
    1310                 1315                 1320             


Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ala Gly Gln  Lys Gly Glu 
    1325                 1330                 1335             


Arg Gly  Glu Pro Gly Gly Gly  Gly Phe Phe Gly Ser  Ser Leu Pro 
    1340                 1345                 1350             


Gly Pro  Pro Gly Pro Pro Gly  Pro Pro Gly Pro Arg  Gly Tyr Pro 
    1355                 1360                 1365             


Gly Ile  Pro Gly Pro Lys Gly  Glu Ser Ile Arg Gly  Gln Pro Gly 
    1370                 1375                 1380             


Pro Pro  Gly Pro Gln Gly Pro  Pro Gly Ile Gly Tyr  Glu Gly Arg 
    1385                 1390                 1395             


Gln Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Ser Phe 
    1400                 1405                 1410             


Pro Gly  Pro His Arg Gln Thr  Ile Ser Val Pro Gly  Pro Pro Gly 
    1415                 1420                 1425             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Thr Met Gly  Ala Ser Ser 
    1430                 1435                 1440             


Gly Val  Arg Leu Trp Ala Thr  Arg Gln Ala Met Leu  Gly Gln Val 
    1445                 1450                 1455             


His Glu  Val Pro Glu Gly Trp  Leu Ile Phe Val Ala  Glu Gln Glu 
    1460                 1465                 1470             


Glu Leu  Tyr Val Arg Val Gln  Asn Gly Phe Arg Lys  Val Gln Leu 
    1475                 1480                 1485             


Glu Ala  Arg Thr Pro Leu Pro  Arg Gly Thr Asp Asn  Glu Val Ala 
    1490                 1495                 1500             


Ala Leu  Gln Pro Pro Val Val  Gln Leu His Asp Ser  Asn Pro Tyr 
    1505                 1510                 1515             


Pro Arg  Arg Glu His Pro His  Pro Thr Ala Arg Pro  Trp Arg Ala 
    1520                 1525                 1530             


Asp Asp  Ile Leu Ala Ser Pro  Pro Arg Leu Pro Glu  Pro Gln Pro 
    1535                 1540                 1545             


Tyr Pro  Gly Ala Pro His His  Ser Ser Tyr Val His  Leu Arg Pro 
    1550                 1555                 1560             


Ala Arg  Pro Thr Ser Pro Pro  Ala His Ser His Arg  Asp Phe Gln 
    1565                 1570                 1575             


Pro Val  Leu His Leu Val Ala  Leu Asn Ser Pro Leu  Ser Gly Gly 
    1580                 1585                 1590             


Met Arg  Gly Ile Arg Gly Ala  Asp Phe Gln Cys Phe  Gln Gln Ala 
    1595                 1600                 1605             


Arg Ala  Val Gly Leu Ala Gly  Thr Phe Arg Ala Phe  Leu Ser Ser 
    1610                 1615                 1620             


Arg Leu  Gln Asp Leu Tyr Ser  Ile Val Arg Arg Ala  Asp Arg Ala 
    1625                 1630                 1635             


Ala Val  Pro Ile Val Asn Leu  Lys Asp Glu Leu Leu  Phe Pro Ser 
    1640                 1645                 1650             


Trp Glu  Ala Leu Phe Ser Gly  Ser Glu Gly Pro Leu  Lys Pro Gly 
    1655                 1660                 1665             


Ala Arg  Ile Phe Ser Phe Asp  Gly Lys Asp Val Leu  Arg His Pro 
    1670                 1675                 1680             


Thr Trp  Pro Gln Lys Ser Val  Trp His Gly Ser Asp  Pro Asn Gly 
    1685                 1690                 1695             


Arg Arg  Leu Thr Glu Ser Tyr  Cys Glu Thr Trp Arg  Thr Glu Ala 
    1700                 1705                 1710             


Pro Ser  Ala Thr Gly Gln Ala  Ser Ser Leu Leu Gly  Gly Arg Leu 
    1715                 1720                 1725             


Leu Gly  Gln Ser Ala Ala Ser  Cys His His Ala Tyr  Ile Val Leu 
    1730                 1735                 1740             


Cys Ile  Glu Asn Ser Phe Met  Thr Ala Ser Lys 
    1745                 1750                 


<210>  14
<211>  1838
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 
1               5                   10                  15      


Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 
            20                  25                  30          


Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 
        35                  40                  45              


His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 
    50                  55                  60                  


Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 
65                  70                  75                  80  


Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 
                85                  90                  95      


Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 
            100                 105                 110         


Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 
        115                 120                 125             


Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 
    130                 135                 140                 


Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 
145                 150                 155                 160 


Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 
                165                 170                 175     


Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 
            180                 185                 190         


Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 
        195                 200                 205             


Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 
    210                 215                 220                 


Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 
225                 230                 235                 240 


Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 
                245                 250                 255     


Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 
            260                 265                 270         


Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 
        275                 280                 285             


Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 
    290                 295                 300                 


Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 
305                 310                 315                 320 


Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 
                325                 330                 335     


Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 
            340                 345                 350         


Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 
        355                 360                 365             


Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 
    370                 375                 380                 


Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 
385                 390                 395                 400 


Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 
                405                 410                 415     


Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 
            420                 425                 430         


Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 
        435                 440                 445             


Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 
    450                 455                 460                 


Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 
                485                 490                 495     


Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 
            500                 505                 510         


Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 
        515                 520                 525             


Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 
    530                 535                 540                 


Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 
545                 550                 555                 560 


Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 
                565                 570                 575     


Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 
            580                 585                 590         


Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 
        595                 600                 605             


Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 
    610                 615                 620                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 
625                 630                 635                 640 


Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 
                645                 650                 655     


Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 
            660                 665                 670         


Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 
        675                 680                 685             


Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 
                725                 730                 735     


Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 
            740                 745                 750         


Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 
        755                 760                 765             


Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 
    770                 775                 780                 


Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 
785                 790                 795                 800 


Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                805                 810                 815     


Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 
            820                 825                 830         


Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 
        835                 840                 845             


Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 
    850                 855                 860                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 
865                 870                 875                 880 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 
                885                 890                 895     


Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 
            900                 905                 910         


Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 
        915                 920                 925             


Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 
    930                 935                 940                 


Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 
945                 950                 955                 960 


Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 
                965                 970                 975     


His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 
            980                 985                 990         


Pro Gly Pro Pro Gly Val Val Gly  Pro Gln Gly Pro Thr  Gly Glu Thr 
        995                 1000                 1005             


Gly Pro  Met Gly Glu Arg Gly  His Pro Gly Pro Pro  Gly Pro Pro 
    1010                 1015                 1020             


Gly Glu  Gln Gly Leu Pro Gly  Leu Ala Gly Lys Glu  Gly Thr Lys 
    1025                 1030                 1035             


Gly Asp  Pro Gly Pro Ala Gly  Leu Pro Gly Lys Asp  Gly Pro Pro 
    1040                 1045                 1050             


Gly Leu  Arg Gly Phe Pro Gly  Asp Arg Gly Leu Pro  Gly Pro Val 
    1055                 1060                 1065             


Gly Ala  Leu Gly Leu Lys Gly  Asn Glu Gly Pro Pro  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Ser Pro Gly  Glu Arg Gly Pro Ala  Gly Ala Ala 
    1085                 1090                 1095             


Gly Pro  Ile Gly Ile Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1115                 1120                 1125             


Gly Pro  Ala Gly Arg Asp Gly  Leu Gln Gly Pro Val  Gly Leu Pro 
    1130                 1135                 1140             


Gly Pro  Ala Gly Pro Val Gly  Pro Pro Gly Glu Asp  Gly Asp Lys 
    1145                 1150                 1155             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1160                 1165                 1170             


Gly Glu  Gln Gly Pro Pro Gly  Pro Thr Gly Pro Gln  Gly Pro Ile 
    1175                 1180                 1185             


Gly Gln  Pro Gly Pro Ser Gly  Ala Asp Gly Glu Pro  Gly Pro Arg 
    1190                 1195                 1200             


Gly Gln  Gln Gly Leu Phe Gly  Gln Lys Gly Asp Glu  Gly Pro Arg 
    1205                 1210                 1215             


Gly Phe  Pro Gly Pro Pro Gly  Pro Val Gly Leu Gln  Gly Leu Pro 
    1220                 1225                 1230             


Gly Pro  Pro Gly Glu Lys Gly  Glu Thr Gly Asp Val  Gly Gln Met 
    1235                 1240                 1245             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Ser  Gly Ala Pro 
    1250                 1255                 1260             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Gly Ile  Gly Asn Pro 
    1265                 1270                 1275             


Gly Ala  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Glu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Glu Gly Gly  Pro Pro Gly Pro Lys  Gly Glu Arg 
    1295                 1300                 1305             


Gly Glu  Lys Gly Glu Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Ser Pro 
    1325                 1330                 1335             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1340                 1345                 1350             


Gly Pro  Ala Gly Gln Asp Gly  Pro Pro Gly Asp Lys  Gly Asp Asp 
    1355                 1360                 1365             


Gly Glu  Pro Gly Gln Thr Gly  Ser Pro Gly Pro Thr  Gly Glu Pro 
    1370                 1375                 1380             


Gly Pro  Ser Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Pro Ala 
    1385                 1390                 1395             


Gly Pro  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1400                 1405                 1410             


Gly Leu  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Ile  Gly Pro Gln 
    1415                 1420                 1425             


Gly Ala  Pro Gly Lys Pro Gly  Pro Asp Gly Leu Arg  Gly Ile Pro 
    1430                 1435                 1440             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ser Pro  Gly Pro Asp 
    1445                 1450                 1455             


Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly Leu Pro  Gly Leu Lys 
    1460                 1465                 1470             


Gly Asp  Ser Gly Pro Lys Gly  Glu Lys Gly His Pro  Gly Leu Ile 
    1475                 1480                 1485             


Gly Leu  Ile Gly Pro Pro Gly  Glu Gln Gly Glu Lys  Gly Asp Arg 
    1490                 1495                 1500             


Gly Leu  Pro Gly Pro Gln Gly  Ser Ser Gly Pro Lys  Gly Glu Gln 
    1505                 1510                 1515             


Gly Ile  Thr Gly Pro Ser Gly  Pro Ile Gly Pro Pro  Gly Pro Pro 
    1520                 1525                 1530             


Gly Leu  Pro Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Ser Ser 
    1535                 1540                 1545             


Gly Pro  Thr Gly Pro Lys Gly  Glu Ala Gly His Pro  Gly Pro Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Pro Gly  Glu Val Ile Gln Pro  Leu Pro Ile 
    1565                 1570                 1575             


Gln Ala  Ser Arg Thr Arg Arg  Asn Ile Asp Ala Ser  Gln Leu Leu 
    1580                 1585                 1590             


Asp Asp  Gly Asn Gly Glu Asn  Tyr Val Asp Tyr Ala  Asp Gly Met 
    1595                 1600                 1605             


Glu Glu  Ile Phe Gly Ser Leu  Asn Ser Leu Lys Leu  Glu Ile Glu 
    1610                 1615                 1620             


Gln Met  Lys Arg Pro Leu Gly  Thr Gln Gln Asn Pro  Ala Arg Thr 
    1625                 1630                 1635             


Cys Lys  Asp Leu Gln Leu Cys  His Pro Asp Phe Pro  Asp Gly Glu 
    1640                 1645                 1650             


Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ser Arg Asp  Ser Phe Lys 
    1655                 1660                 1665             


Val Tyr  Cys Asn Phe Thr Ala  Gly Gly Ser Thr Cys  Val Phe Pro 
    1670                 1675                 1680             


Asp Lys  Lys Ser Glu Gly Ala  Arg Ile Thr Ser Trp  Pro Lys Glu 
    1685                 1690                 1695             


Asn Pro  Gly Ser Trp Phe Ser  Glu Phe Lys Arg Gly  Lys Leu Leu 
    1700                 1705                 1710             


Ser Tyr  Val Asp Ala Glu Gly  Asn Pro Val Gly Val  Val Gln Met 
    1715                 1720                 1725             


Thr Phe  Leu Arg Leu Leu Ser  Ala Ser Ala His Gln  Asn Val Thr 
    1730                 1735                 1740             


Tyr His  Cys Tyr Gln Ser Val  Ala Trp Gln Asp Ala  Ala Thr Gly 
    1745                 1750                 1755             


Ser Tyr  Asp Lys Ala Leu Arg  Phe Leu Gly Ser Asn  Asp Glu Glu 
    1760                 1765                 1770             


Met Ser  Tyr Asp Asn Asn Pro  Tyr Ile Arg Ala Leu  Val Asp Gly 
    1775                 1780                 1785             


Cys Ala  Thr Lys Lys Gly Tyr  Gln Lys Thr Val Leu  Glu Ile Asp 
    1790                 1795                 1800             


Thr Pro  Lys Val Glu Gln Val  Pro Ile Val Asp Ile  Met Phe Asn 
    1805                 1810                 1815             


Asp Phe  Gly Glu Ala Ser Gln  Lys Phe Gly Phe Glu  Val Gly Pro 
    1820                 1825                 1830             


Ala Cys  Phe Met Gly 
    1835             


<210>  15
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Glu Ala Gly Glu Ala Thr Thr Thr Thr Thr Thr Thr Leu Pro 
1               5                   10                  15      


Gln Ala Pro Thr Glu Ala Ala Ala Ala Ala Pro Gln Asp Pro Ala Pro 
            20                  25                  30          


Lys Ser Pro Val Gly Ser Gly Ala Pro Gln Ala Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Ala His Val Ala Gly Asn Pro Gly Gly Asp Ala Ala Pro Ala Ala 
    50                  55                  60                  


Thr Gly Thr Ala Ala Ala Ala Ser Leu Ala Thr Ala Ala Gly Ser Glu 
65                  70                  75                  80  


Asp Ala Glu Lys Lys Val Leu Ala Thr Lys Val Leu Gly Thr Val Lys 
                85                  90                  95      


Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr 
            100                 105                 110         


Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro 
        115                 120                 125             


Arg Lys Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp 
    130                 135                 140                 


Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro 
145                 150                 155                 160 


Asp Gly Val Pro Val Glu Gly Ser Arg Tyr Ala Ala Asp Arg Arg Arg 
                165                 170                 175     


Tyr Arg Arg Gly Tyr Tyr Gly Arg Arg Arg Gly Pro Pro Arg Asn Tyr 
            180                 185                 190         


Ala Gly Glu Glu Glu Glu Glu Gly Ser Gly Ser Ser Glu Gly Phe Asp 
        195                 200                 205             


Pro Pro Ala Thr Asp Arg Gln Phe Ser Gly Ala Arg Asn Gln Leu Arg 
    210                 215                 220                 


Arg Pro Gln Tyr Arg Pro Gln Tyr Arg Gln Arg Arg Phe Pro Pro Tyr 
225                 230                 235                 240 


His Val Gly Gln Thr Phe Asp Arg Arg Ser Arg Val Leu Pro His Pro 
                245                 250                 255     


Asn Arg Ile Gln Ala Gly Glu Ile Gly Glu Met Lys Asp Gly Val Pro 
            260                 265                 270         


Glu Gly Ala Gln Leu Gln Gly Pro Val His Arg Asn Pro Thr Tyr Arg 
        275                 280                 285             


Pro Arg Tyr Arg Ser Arg Gly Pro Pro Arg Pro Arg Pro Ala Pro Ala 
    290                 295                 300                 


Val Gly Glu Ala Glu Asp Lys Glu Asn Gln Gln Ala Thr Ser Gly Pro 
305                 310                 315                 320 


Asn Gln Pro Ser Val Arg Arg Gly Tyr Arg Arg Pro Tyr Asn Tyr Arg 
                325                 330                 335     


Arg Arg Pro Arg Pro Pro Asn Ala Pro Ser Gln Asp Gly Lys Glu Ala 
            340                 345                 350         


Lys Ala Gly Glu Ala Pro Thr Glu Asn Pro Ala Pro Pro Thr Gln Gln 
        355                 360                 365             


Ser Ser Ala Glu 
    370         


<210>  16
<211>  1068
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Ser Ala Ala Lys Pro Trp Asn Pro Ala Ile Arg Ala Gly Gly 
1               5                   10                  15      


His Gly Pro Asp Arg Val Arg Pro Leu Pro Ala Ala Ser Ser Gly Met 
            20                  25                  30          


Lys Ser Ser Lys Ser Ser Thr Ser Leu Ala Phe Glu Ser Arg Leu Ser 
        35                  40                  45              


Arg Leu Lys Arg Ala Ser Ser Glu Asp Thr Leu Asn Lys Pro Gly Ser 
    50                  55                  60                  


Thr Ala Ala Ser Gly Val Val Arg Leu Lys Lys Thr Ala Thr Ala Gly 
65                  70                  75                  80  


Ala Ile Ser Glu Leu Thr Glu Ser Arg Leu Arg Ser Gly Thr Gly Ala 
                85                  90                  95      


Phe Thr Thr Thr Lys Arg Thr Gly Ile Pro Ala Pro Arg Glu Phe Ser 
            100                 105                 110         


Val Thr Val Ser Arg Glu Arg Ser Val Pro Arg Gly Pro Ser Asn Pro 
        115                 120                 125             


Arg Lys Ser Val Ser Ser Pro Thr Ser Ser Asn Thr Pro Thr Pro Thr 
    130                 135                 140                 


Lys His Leu Arg Thr Pro Ser Thr Lys Pro Lys Gln Glu Asn Glu Gly 
145                 150                 155                 160 


Gly Glu Lys Ala Ala Leu Glu Ser Gln Val Arg Glu Leu Leu Ala Glu 
                165                 170                 175     


Ala Lys Ala Lys Asp Ser Glu Ile Asn Arg Leu Arg Ser Glu Leu Lys 
            180                 185                 190         


Lys Tyr Lys Glu Lys Arg Thr Leu Asn Ala Glu Gly Thr Asp Ala Leu 
        195                 200                 205             


Gly Pro Asn Val Asp Gly Thr Ser Val Ser Pro Gly Asp Thr Glu Pro 
    210                 215                 220                 


Met Ile Arg Ala Leu Glu Glu Lys Asn Lys Asn Phe Gln Lys Glu Leu 
225                 230                 235                 240 


Ser Asp Leu Glu Glu Glu Asn Arg Val Leu Lys Glu Lys Leu Ile Tyr 
                245                 250                 255     


Leu Glu His Ser Pro Asn Ser Glu Gly Ala Ala Ser His Thr Gly Asp 
            260                 265                 270         


Ser Ser Cys Pro Thr Ser Ile Thr Gln Glu Ser Ser Phe Gly Ser Pro 
        275                 280                 285             


Thr Gly Asn Gln Met Ser Ser Asp Ile Asp Glu Tyr Lys Lys Asn Ile 
    290                 295                 300                 


His Gly Asn Ala Leu Arg Thr Ser Gly Ser Ser Ser Ser Asp Val Thr 
305                 310                 315                 320 


Lys Ala Ser Leu Ser Pro Asp Ala Ser Asp Phe Glu His Ile Thr Ala 
                325                 330                 335     


Glu Thr Pro Ser Arg Pro Leu Ser Ser Thr Ser Asn Pro Phe Lys Ser 
            340                 345                 350         


Ser Lys Cys Ser Thr Ala Gly Ser Ser Pro Asn Ser Val Ser Glu Leu 
        355                 360                 365             


Ser Leu Ala Ser Leu Thr Glu Lys Ile Gln Lys Met Glu Glu Asn His 
    370                 375                 380                 


His Ser Thr Ala Glu Glu Leu Gln Ala Thr Leu Gln Glu Leu Ser Asp 
385                 390                 395                 400 


Gln Gln Gln Met Val Gln Glu Leu Thr Ala Glu Asn Glu Lys Leu Val 
                405                 410                 415     


Asp Glu Lys Thr Ile Leu Glu Thr Ser Phe His Gln His Arg Glu Arg 
            420                 425                 430         


Ala Glu Gln Leu Ser Gln Glu Asn Glu Lys Leu Met Asn Leu Leu Gln 
        435                 440                 445             


Glu Arg Val Lys Asn Glu Glu Pro Thr Thr Gln Glu Gly Lys Ile Ile 
    450                 455                 460                 


Glu Leu Glu Gln Lys Cys Thr Gly Ile Leu Glu Gln Gly Arg Phe Glu 
465                 470                 475                 480 


Arg Glu Lys Leu Leu Asn Ile Gln Gln Gln Leu Thr Cys Ser Leu Arg 
                485                 490                 495     


Lys Val Glu Glu Glu Asn Gln Gly Ala Leu Glu Met Ile Lys Arg Leu 
            500                 505                 510         


Lys Glu Glu Asn Glu Lys Leu Asn Glu Phe Leu Glu Leu Glu Arg His 
        515                 520                 525             


Asn Asn Asn Met Met Ala Lys Thr Leu Glu Glu Cys Arg Val Thr Leu 
    530                 535                 540                 


Glu Gly Leu Lys Met Glu Asn Gly Ser Leu Lys Ser His Leu Gln Gly 
545                 550                 555                 560 


Glu Lys Gln Lys Ala Thr Glu Ala Ser Ala Val Glu Gln Thr Ala Glu 
                565                 570                 575     


Ser Cys Glu Val Gln Glu Met Leu Lys Val Ala Arg Ala Glu Lys Asp 
            580                 585                 590         


Leu Leu Glu Leu Ser Cys Asn Glu Leu Arg Gln Glu Leu Leu Lys Ala 
        595                 600                 605             


Asn Gly Glu Ile Lys His Val Ser Ser Leu Leu Ala Lys Val Glu Lys 
    610                 615                 620                 


Asp Tyr Ser Tyr Leu Lys Glu Ile Cys Asp His Gln Ala Glu Gln Leu 
625                 630                 635                 640 


Ser Arg Thr Ser Leu Lys Leu Gln Glu Lys Ala Ser Glu Ser Asp Ala 
                645                 650                 655     


Glu Ile Lys Asp Met Lys Glu Thr Ile Phe Glu Leu Glu Asp Gln Val 
            660                 665                 670         


Glu Gln His Arg Ala Val Lys Leu His Asn Asn Gln Leu Ile Ser Glu 
        675                 680                 685             


Leu Glu Ser Ser Val Ile Lys Leu Glu Glu Gln Lys Ser Asp Leu Glu 
    690                 695                 700                 


Arg Gln Leu Lys Thr Leu Thr Lys Gln Met Lys Glu Glu Thr Glu Glu 
705                 710                 715                 720 


Trp Arg Arg Phe Gln Ala Asp Leu Gln Thr Ala Val Val Val Ala Asn 
                725                 730                 735     


Asp Ile Lys Cys Glu Ala Gln Gln Glu Leu Arg Thr Val Lys Arg Lys 
            740                 745                 750         


Leu Leu Glu Glu Glu Glu Lys Asn Ala Arg Leu Gln Lys Glu Leu Gly 
        755                 760                 765             


Asp Val Gln Gly His Gly Arg Val Val Thr Ser Arg Ala Ala Pro Pro 
    770                 775                 780                 


Pro Val Asp Glu Glu Pro Glu Ser Ser Glu Val Asp Ala Ala Gly Arg 
785                 790                 795                 800 


Trp Pro Gly Val Cys Val Ser Arg Thr Ser Pro Thr Pro Pro Glu Ser 
                805                 810                 815     


Ala Thr Thr Val Lys Ser Leu Ile Lys Ser Phe Asp Leu Gly Arg Pro 
            820                 825                 830         


Gly Gly Ala Gly Gln Asn Ile Ser Val His Lys Thr Pro Arg Ser Pro 
        835                 840                 845             


Leu Ser Gly Ile Pro Val Arg Thr Ala Pro Ala Ala Ala Val Ser Pro 
    850                 855                 860                 


Met Gln Arg His Ser Thr Tyr Ser Ser Val Arg Pro Ala Ser Arg Gly 
865                 870                 875                 880 


Val Thr Gln Arg Leu Asp Leu Pro Asp Leu Pro Leu Ser Asp Ile Leu 
                885                 890                 895     


Lys Gly Arg Thr Glu Thr Leu Lys Pro Asp Pro His Leu Arg Lys Ser 
            900                 905                 910         


Pro Ser Leu Glu Ser Leu Ser Arg Pro Pro Ser Leu Gly Phe Gly Asp 
        915                 920                 925             


Thr Arg Leu Leu Ser Ala Ser Thr Arg Ala Trp Lys Pro Gln Ser Lys 
    930                 935                 940                 


Leu Ser Val Glu Arg Lys Asp Pro Leu Ala Ala Leu Ala Arg Glu Tyr 
945                 950                 955                 960 


Gly Gly Ser Lys Arg Asn Ala Leu Leu Lys Trp Cys Gln Lys Lys Thr 
                965                 970                 975     


Gln Gly Tyr Ala Asn Ile Asp Ile Thr Asn Phe Ser Ser Ser Trp Ser 
            980                 985                 990         


Asp Gly Leu Ala Phe Cys Ala Leu  Leu His Thr Tyr Leu  Pro Ala His 
        995                 1000                 1005             


Ile Pro  Tyr Gln Glu Leu Asn  Ser Gln Glu Lys Lys  Arg Asn Leu 
    1010                 1015                 1020             


Leu Leu  Ala Phe Glu Ala Ala  Glu Ser Val Gly Ile  Lys Pro Ser 
    1025                 1030                 1035             


Leu Glu  Leu Ser Glu Met Leu  Tyr Thr Asp Arg Pro  Asp Trp Gln 
    1040                 1045                 1050             


Ser Val  Met Gln Tyr Val Ala  Gln Ile Tyr Lys Tyr  Phe Glu Thr 
    1055                 1060                 1065             


<210>  17
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys 
1               5                   10                  15      


Ala Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys 
            20                  25                  30          


Ser Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser 
        35                  40                  45              


Ala Arg Ala Gly Glu Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln 
    50                  55                  60                  


Glu Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu 
65                  70                  75                  80  


Leu Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ala 
                85                  90                  95      


Gly Phe Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser 
            100                 105                 110         


Ser Glu Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val 
        115                 120                 125             


Val Asp Cys Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg 
    130                 135                 140                 


Gln Ala Ile Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met 
145                 150                 155                 160 


Asp Arg Ala Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln 
                165                 170                 175     


Thr Phe Gln Arg Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr 
            180                 185                 190         


Gly Glu Gly Glu Ser Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val 
        195                 200                 205             


Leu Gly Thr Val Gly Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr 
    210                 215                 220                 


Leu Lys Gln Phe Ala Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly 
225                 230                 235                 240 


Glu Gly Gln Leu Gly Pro Ala Glu Arg Ala Lys Lys Val Glu Asp Met 
                245                 250                 255     


Met Lys Lys Leu Trp Gly Asp Arg Tyr Phe Asp Pro Ala Asn Gly Lys 
            260                 265                 270         


Phe Ser Lys Ser Ala Thr Ser Pro Glu Gly Lys Lys Leu Pro Arg Thr 
        275                 280                 285             


Phe Cys Gln Leu Ile Leu Asp Pro Ile Phe Lys Val Phe Asp Ala Ile 
    290                 295                 300                 


Met Asn Phe Lys Lys Glu Glu Thr Ala Lys Leu Ile Glu Lys Leu Asp 
305                 310                 315                 320 


Ile Lys Leu Asp Ser Glu Asp Lys Asp Lys Glu Gly Lys Pro Leu Leu 
                325                 330                 335     


Lys Ala Val Met Arg Arg Trp Leu Pro Ala Gly Asp Ala Leu Leu Gln 
            340                 345                 350         


Met Ile Thr Ile His Leu Pro Ser Pro Val Thr Ala Gln Lys Tyr Arg 
        355                 360                 365             


Cys Glu Leu Leu Tyr Glu Gly Pro Pro Asp Asp Glu Ala Ala Met Gly 
    370                 375                 380                 


Ile Lys Ser Cys Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys 
385                 390                 395                 400 


Met Val Pro Thr Ser Asp Lys Gly Arg Phe Tyr Ala Phe Gly Arg Val 
                405                 410                 415     


Phe Ser Gly Leu Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro 
            420                 425                 430         


Asn Tyr Thr Pro Gly Lys Lys Glu Asp Leu Tyr Leu Lys Pro Ile Gln 
        435                 440                 445             


Arg Thr Ile Leu Met Met Gly Arg Tyr Val Glu Pro Ile Glu Asp Val 
    450                 455                 460                 


Pro Cys Gly Asn Ile Val Gly Leu Val Gly Val Asp Gln Phe Leu Val 
465                 470                 475                 480 


Lys Thr Gly Thr Ile Thr Thr Phe Glu His Ala His Asn Met Arg Val 
                485                 490                 495     


Met Lys Phe Ser Val Ser Pro Val Val Arg Val Ala Val Glu Ala Lys 
            500                 505                 510         


Asn Pro Ala Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg Leu Ala 
        515                 520                 525             


Lys Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly Glu His 
    530                 535                 540                 


Ile Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu Lys Asp 
545                 550                 555                 560 


Leu Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp Pro Val 
                565                 570                 575     


Val Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu Cys Leu 
            580                 585                 590         


Ser Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala Arg Pro 
        595                 600                 605             


Phe Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val Ser Ala 
    610                 615                 620                 


Arg Gln Glu Leu Lys Gln Arg Ala Arg Tyr Leu Ala Glu Lys Tyr Glu 
625                 630                 635                 640 


Trp Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro Asp Gly 
                645                 650                 655     


Thr Gly Pro Asn Ile Leu Thr Asp Ile Thr Lys Gly Val Gln Tyr Leu 
            660                 665                 670         


Asn Glu Ile Lys Asp Ser Val Val Ala Gly Phe Gln Trp Ala Thr Lys 
        675                 680                 685             


Glu Gly Ala Leu Cys Glu Glu Asn Met Arg Gly Val Arg Phe Asp Val 
    690                 695                 700                 


His Asp Val Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln 
705                 710                 715                 720 


Ile Ile Pro Thr Ala Arg Arg Cys Leu Tyr Ala Ser Val Leu Thr Ala 
                725                 730                 735     


Gln Pro Arg Leu Met Glu Pro Ile Tyr Leu Val Glu Ile Gln Cys Pro 
            740                 745                 750         


Glu Gln Val Val Gly Gly Ile Tyr Gly Val Leu Asn Arg Lys Arg Gly 
        755                 760                 765             


His Val Phe Glu Glu Ser Gln Val Ala Gly Thr Pro Met Phe Val Val 
    770                 775                 780                 


Lys Ala Tyr Leu Pro Val Asn Glu Ser Phe Gly Phe Thr Ala Asp Leu 
785                 790                 795                 800 


Arg Ser Asn Thr Gly Gly Gln Ala Phe Pro Gln Cys Val Phe Asp His 
                805                 810                 815     


Trp Gln Ile Leu Pro Gly Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser 
            820                 825                 830         


Gln Val Val Ala Glu Thr Arg Lys Arg Lys Gly Leu Lys Glu Gly Ile 
        835                 840                 845             


Pro Ala Leu Asp Asn Phe Leu Asp Lys Leu 
    850                 855             


<210>  18
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp 
            340                 345                 350         


Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu 
        355                 360                 365             


Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val 
    370                 375                 380                 


Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile 
385                 390                 395                 400 


Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg 
                405                 410                 415     


Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly 
            420                 425                 430         


Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly 
        435                 440                 445             


Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro 
    450                 455                 460                 


Arg Gln 
465     


<210>  19
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu Ser 
1               5                   10                  15      


Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn Ile 
            20                  25                  30          


Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile Met 
        35                  40                  45              


Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly Leu 
    50                  55                  60                  


Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu Gln Ile Pro 
65                  70                  75                  80  


Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly Ser 
                85                  90                  95      


Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro Glu 
            100                 105                 110         


Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser Arg 
        115                 120                 125             


Asn Glu Asp Ile Thr Glu Pro Gln Ser Ile Leu Ala Ala Ala Glu Lys 
    130                 135                 140                 


Ala Gly Met Ser Ala Glu Gln Ala Gln Gly Leu Leu Glu Lys Ile Ala 
145                 150                 155                 160 


Thr Pro Lys Val Lys Asn Gln Leu Lys Glu Thr Thr Glu Ala Ala Cys 
                165                 170                 175     


Arg Tyr Gly Ala Phe Gly Leu Pro Ile Thr Val Ala His Val Asp Gly 
            180                 185                 190         


Gln Thr His Met Leu Phe Gly Ser Asp Arg Met Glu Leu Leu Ala His 
        195                 200                 205             


Leu Leu Gly Glu Lys Trp Met Gly Pro Ile Pro Pro Ala Val Asn Ala 
    210                 215                 220                 


Arg Leu 
225     


<210>  20
<211>  2035
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Ser Ala Val Ser Pro Ala Asn Leu Pro Ala Val Leu Leu Gln 
1               5                   10                  15      


Pro Arg Trp Lys Arg Val Val Gly Trp Ser Gly Pro Val Pro Arg Pro 
            20                  25                  30          


Arg His Gly His Arg Ala Val Ala Ile Lys Glu Leu Ile Val Val Phe 
        35                  40                  45              


Gly Gly Gly Asn Glu Gly Ile Val Asp Glu Leu His Val Tyr Asn Thr 
    50                  55                  60                  


Ala Thr Asn Gln Trp Phe Ile Pro Ala Val Arg Gly Asp Ile Pro Pro 
65                  70                  75                  80  


Gly Cys Ala Ala Tyr Gly Phe Val Cys Asp Gly Thr Arg Leu Leu Val 
                85                  90                  95      


Phe Gly Gly Met Val Glu Tyr Gly Lys Tyr Ser Asn Asp Leu Tyr Glu 
            100                 105                 110         


Leu Gln Ala Ser Arg Trp Glu Trp Lys Arg Leu Lys Ala Lys Thr Pro 
        115                 120                 125             


Lys Asn Gly Pro Pro Pro Cys Pro Arg Leu Gly His Ser Phe Ser Leu 
    130                 135                 140                 


Val Gly Asn Lys Cys Tyr Leu Phe Gly Gly Leu Ala Asn Asp Ser Glu 
145                 150                 155                 160 


Asp Pro Lys Asn Asn Ile Pro Arg Tyr Leu Asn Asp Leu Tyr Ile Leu 
                165                 170                 175     


Glu Leu Arg Pro Gly Ser Gly Val Val Ala Trp Asp Ile Pro Ile Thr 
            180                 185                 190         


Tyr Gly Val Leu Pro Pro Pro Arg Glu Ser His Thr Ala Val Val Tyr 
        195                 200                 205             


Thr Glu Lys Asp Asn Lys Lys Ser Lys Leu Val Ile Tyr Gly Gly Met 
    210                 215                 220                 


Ser Gly Cys Arg Leu Gly Asp Leu Trp Thr Leu Asp Ile Asp Thr Leu 
225                 230                 235                 240 


Thr Trp Asn Lys Pro Ser Leu Ser Gly Val Ala Pro Leu Pro Arg Ser 
                245                 250                 255     


Leu His Ser Ala Thr Thr Ile Gly Asn Lys Met Tyr Val Phe Gly Gly 
            260                 265                 270         


Trp Val Pro Leu Val Met Asp Asp Val Lys Val Ala Thr His Glu Lys 
        275                 280                 285             


Glu Trp Lys Cys Thr Asn Thr Leu Ala Cys Leu Asn Leu Asp Thr Met 
    290                 295                 300                 


Ala Trp Glu Thr Ile Leu Met Asp Thr Leu Glu Asp Asn Ile Pro Arg 
305                 310                 315                 320 


Ala Arg Ala Gly His Cys Ala Val Ala Ile Asn Thr Arg Leu Tyr Ile 
                325                 330                 335     


Trp Ser Gly Arg Asp Gly Tyr Arg Lys Ala Trp Asn Asn Gln Val Cys 
            340                 345                 350         


Cys Lys Asp Leu Trp Tyr Leu Glu Thr Glu Lys Pro Pro Pro Pro Ala 
        355                 360                 365             


Arg Val Gln Leu Val Arg Ala Asn Thr Asn Ser Leu Glu Val Ser Trp 
    370                 375                 380                 


Gly Ala Val Ala Thr Ala Asp Ser Tyr Leu Leu Gln Leu Gln Lys Tyr 
385                 390                 395                 400 


Asp Ile Pro Ala Thr Ala Ala Thr Ala Thr Ser Pro Thr Pro Asn Pro 
                405                 410                 415     


Val Pro Ser Val Pro Ala Asn Pro Pro Lys Ser Pro Ala Pro Ala Ala 
            420                 425                 430         


Ala Ala Pro Ala Val Gln Pro Leu Thr Gln Val Gly Ile Thr Leu Leu 
        435                 440                 445             


Pro Gln Ala Ala Pro Ala Pro Pro Thr Thr Thr Thr Ile Gln Val Leu 
    450                 455                 460                 


Pro Thr Val Pro Gly Ser Ser Ile Ser Val Pro Thr Ala Ala Arg Thr 
465                 470                 475                 480 


Gln Gly Val Pro Ala Val Leu Lys Val Thr Gly Pro Gln Ala Thr Thr 
                485                 490                 495     


Gly Thr Pro Leu Val Thr Met Arg Pro Ala Ser Gln Ala Gly Lys Ala 
            500                 505                 510         


Pro Val Thr Val Thr Ser Leu Pro Ala Gly Val Arg Met Val Val Pro 
        515                 520                 525             


Thr Gln Ser Ala Gln Gly Thr Val Ile Gly Ser Ser Pro Gln Met Ser 
    530                 535                 540                 


Gly Met Ala Ala Leu Ala Ala Ala Ala Ala Ala Thr Gln Lys Ile Pro 
545                 550                 555                 560 


Pro Ser Ser Ala Pro Thr Val Leu Ser Val Pro Ala Gly Thr Thr Ile 
                565                 570                 575     


Val Lys Thr Met Ala Val Thr Pro Gly Thr Thr Thr Leu Pro Ala Thr 
            580                 585                 590         


Val Lys Val Ala Ser Ser Pro Val Met Val Ser Asn Pro Ala Thr Arg 
        595                 600                 605             


Met Leu Lys Thr Ala Ala Ala Gln Val Gly Thr Ser Val Ser Ser Ala 
    610                 615                 620                 


Thr Asn Thr Ser Thr Arg Pro Ile Ile Thr Val His Lys Ser Gly Thr 
625                 630                 635                 640 


Val Thr Val Ala Gln Gln Ala Gln Val Val Thr Thr Val Val Gly Gly 
                645                 650                 655     


Val Thr Lys Thr Ile Thr Leu Val Lys Ser Pro Ile Ser Val Pro Gly 
            660                 665                 670         


Gly Ser Ala Leu Ile Ser Asn Leu Gly Lys Val Met Ser Val Val Gln 
        675                 680                 685             


Thr Lys Pro Val Gln Thr Ser Ala Val Thr Gly Gln Ala Ser Thr Gly 
    690                 695                 700                 


Pro Val Thr Gln Ile Ile Gln Thr Lys Gly Pro Leu Pro Ala Gly Thr 
705                 710                 715                 720 


Ile Leu Lys Leu Val Thr Ser Ala Asp Gly Lys Pro Thr Thr Ile Ile 
                725                 730                 735     


Thr Thr Thr Gln Ala Ser Gly Ala Gly Thr Lys Pro Thr Ile Leu Gly 
            740                 745                 750         


Ile Ser Ser Val Ser Pro Ser Thr Thr Lys Pro Gly Thr Thr Thr Ile 
        755                 760                 765             


Ile Lys Thr Ile Pro Met Ser Ala Ile Ile Thr Gln Ala Gly Ala Thr 
    770                 775                 780                 


Gly Val Thr Ser Ser Pro Gly Ile Lys Ser Pro Ile Thr Ile Ile Thr 
785                 790                 795                 800 


Thr Lys Val Met Thr Ser Gly Thr Gly Ala Pro Ala Lys Ile Ile Thr 
                805                 810                 815     


Ala Val Pro Lys Ile Ala Thr Gly His Gly Gln Gln Gly Val Thr Gln 
            820                 825                 830         


Val Val Leu Lys Gly Ala Pro Gly Gln Pro Gly Thr Ile Leu Arg Thr 
        835                 840                 845             


Val Pro Met Gly Gly Val Arg Leu Val Thr Pro Val Thr Val Ser Ala 
    850                 855                 860                 


Val Lys Pro Ala Val Thr Thr Leu Val Val Lys Gly Thr Thr Gly Val 
865                 870                 875                 880 


Thr Thr Leu Gly Thr Val Thr Gly Thr Val Ser Thr Ser Leu Ala Gly 
                885                 890                 895     


Ala Gly Gly His Ser Thr Ser Ala Ser Leu Ala Thr Pro Ile Thr Thr 
            900                 905                 910         


Leu Gly Thr Ile Ala Thr Leu Ser Ser Gln Val Ile Asn Pro Thr Ala 
        915                 920                 925             


Ile Thr Val Ser Ala Ala Gln Thr Thr Leu Thr Ala Ala Gly Gly Leu 
    930                 935                 940                 


Thr Thr Pro Thr Ile Thr Met Gln Pro Val Ser Gln Pro Thr Gln Val 
945                 950                 955                 960 


Thr Leu Ile Thr Ala Pro Ser Gly Val Glu Ala Gln Pro Val His Asp 
                965                 970                 975     


Leu Pro Val Ser Ile Leu Ala Ser Pro Thr Thr Glu Gln Pro Thr Ala 
            980                 985                 990         


Thr Val Thr Ile Ala Asp Ser Gly  Gln Gly Asp Val Gln  Pro Gly Thr 
        995                 1000                 1005             


Val Thr  Leu Val Cys Ser Asn  Pro Pro Cys Glu Thr  His Glu Thr 
    1010                 1015                 1020             


Gly Thr  Thr Asn Thr Ala Thr  Thr Thr Val Val Ala  Asn Leu Gly 
    1025                 1030                 1035             


Gly His  Pro Gln Pro Thr Gln  Val Gln Phe Val Cys  Asp Arg Gln 
    1040                 1045                 1050             


Glu Ala  Ala Ala Ser Leu Val  Thr Ser Thr Val Gly  Gln Gln Asn 
    1055                 1060                 1065             


Gly Ser  Val Val Arg Val Cys  Ser Asn Pro Pro Cys  Glu Thr His 
    1070                 1075                 1080             


Glu Thr  Gly Thr Thr Asn Thr  Ala Thr Thr Ala Thr  Ser Asn Met 
    1085                 1090                 1095             


Ala Gly  Gln His Gly Cys Ser  Asn Pro Pro Cys Glu  Thr His Glu 
    1100                 1105                 1110             


Thr Gly  Thr Thr Asn Thr Ala  Thr Thr Ala Met Ser  Ser Val Gly 
    1115                 1120                 1125             


Ala Asn  His Gln Arg Asp Ala  Arg Arg Ala Cys Ala  Ala Gly Thr 
    1130                 1135                 1140             


Pro Ala  Val Ile Arg Ile Ser  Val Ala Thr Gly Ala  Leu Glu Ala 
    1145                 1150                 1155             


Ala Gln  Gly Ser Lys Ser Gln  Cys Gln Thr Arg Gln  Thr Ser Ala 
    1160                 1165                 1170             


Thr Ser  Thr Thr Met Thr Val  Met Ala Thr Gly Ala  Pro Cys Ser 
    1175                 1180                 1185             


Ala Gly  Pro Leu Leu Gly Pro  Ser Met Ala Arg Glu  Pro Gly Gly 
    1190                 1195                 1200             


Arg Ser  Pro Ala Phe Val Gln  Leu Ala Pro Leu Ser  Ser Lys Val 
    1205                 1210                 1215             


Arg Leu  Ser Ser Pro Ser Ile  Lys Asp Leu Pro Ala  Gly Arg His 
    1220                 1225                 1230             


Ser His  Ala Val Ser Thr Ala  Ala Met Thr Arg Ser  Ser Val Gly 
    1235                 1240                 1245             


Ala Gly  Glu Pro Arg Met Ala  Pro Val Cys Glu Ser  Leu Gln Gly 
    1250                 1255                 1260             


Gly Ser  Pro Ser Thr Thr Val  Thr Val Thr Ala Leu  Glu Ala Leu 
    1265                 1270                 1275             


Leu Cys  Pro Ser Ala Thr Val  Thr Gln Val Cys Ser  Asn Pro Pro 
    1280                 1285                 1290             


Cys Glu  Thr His Glu Thr Gly  Thr Thr Asn Thr Ala  Thr Thr Ser 
    1295                 1300                 1305             


Asn Ala  Gly Ser Ala Gln Arg  Val Cys Ser Asn Pro  Pro Cys Glu 
    1310                 1315                 1320             


Thr His  Glu Thr Gly Thr Thr  His Thr Ala Thr Thr  Ala Thr Ser 
    1325                 1330                 1335             


Asn Gly  Gly Thr Gly Gln Pro  Glu Gly Gly Gln Gln  Pro Pro Ala 
    1340                 1345                 1350             


Gly Arg  Pro Cys Glu Thr His  Gln Thr Thr Ser Thr  Gly Thr Thr 
    1355                 1360                 1365             


Met Ser  Val Ser Val Gly Ala  Leu Leu Pro Asp Ala  Thr Ser Ser 
    1370                 1375                 1380             


His Arg  Thr Val Glu Ser Gly  Leu Glu Val Ala Ala  Ala Pro Ser 
    1385                 1390                 1395             


Val Thr  Pro Gln Ala Gly Thr  Ala Leu Leu Ala Pro  Phe Pro Thr 
    1400                 1405                 1410             


Gln Arg  Val Cys Ser Asn Pro  Pro Cys Glu Thr His  Glu Thr Gly 
    1415                 1420                 1425             


Thr Thr  His Thr Ala Thr Thr  Val Thr Ser Asn Met  Ser Ser Asn 
    1430                 1435                 1440             


Gln Asp  Pro Pro Pro Ala Ala  Ser Asp Gln Gly Glu  Val Glu Ser 
    1445                 1450                 1455             


Thr Gln  Gly Asp Ser Val Asn  Ile Thr Ser Ser Ser  Ala Ile Thr 
    1460                 1465                 1470             


Thr Thr  Val Ser Ser Thr Leu  Thr Arg Ala Val Thr  Thr Val Thr 
    1475                 1480                 1485             


Gln Ser  Thr Pro Val Pro Gly  Pro Ser Val Pro Pro  Pro Glu Glu 
    1490                 1495                 1500             


Leu Gln  Val Ser Pro Gly Pro  Arg Gln Gln Leu Pro  Pro Arg Gln 
    1505                 1510                 1515             


Leu Leu  Gln Ser Ala Ser Thr  Ala Leu Met Gly Glu  Ser Ala Glu 
    1520                 1525                 1530             


Val Leu  Ser Ala Ser Gln Thr  Pro Glu Leu Pro Ala  Ala Val Asp 
    1535                 1540                 1545             


Leu Ser  Ser Thr Gly Glu Pro  Ser Ser Gly Gln Glu  Ser Ala Gly 
    1550                 1555                 1560             


Ser Ala  Val Val Ala Thr Val  Val Val Gln Pro Pro  Pro Pro Thr 
    1565                 1570                 1575             


Gln Ser  Glu Val Asp Gln Leu  Ser Leu Pro Gln Glu  Leu Met Ala 
    1580                 1585                 1590             


Glu Ala  Gln Ala Gly Thr Thr  Thr Leu Met Val Thr  Gly Leu Thr 
    1595                 1600                 1605             


Pro Glu  Glu Leu Ala Val Thr  Ala Ala Ala Glu Ala  Ala Ala Gln 
    1610                 1615                 1620             


Ala Ala  Ala Thr Glu Glu Ala  Gln Ala Leu Ala Ile  Gln Ala Val 
    1625                 1630                 1635             


Leu Gln  Ala Ala Gln Gln Ala  Val Met Gly Thr Gly  Glu Pro Met 
    1640                 1645                 1650             


Asp Thr  Ser Glu Ala Ala Ala  Thr Val Thr Gln Ala  Glu Leu Gly 
    1655                 1660                 1665             


His Leu  Ser Ala Glu Gly Gln  Glu Gly Gln Ala Thr  Thr Ile Pro 
    1670                 1675                 1680             


Ile Val  Leu Thr Gln Gln Glu  Leu Ala Ala Leu Val  Gln Gln Gln 
    1685                 1690                 1695             


Gln Leu  Gln Glu Ala Gln Ala  Gln Gln Gln His His  His Leu Pro 
    1700                 1705                 1710             


Thr Glu  Ala Leu Ala Pro Ala  Asp Ser Leu Asn Asp  Pro Ala Ile 
    1715                 1720                 1725             


Glu Ser  Asn Cys Leu Asn Glu  Leu Ala Gly Thr Val  Pro Ser Thr 
    1730                 1735                 1740             


Val Ala  Leu Leu Pro Ser Thr  Ala Thr Glu Ser Leu  Ala Pro Ser 
    1745                 1750                 1755             


Asn Thr  Phe Val Ala Pro Gln  Pro Val Val Val Ala  Ser Pro Ala 
    1760                 1765                 1770             


Lys Leu  Gln Ala Ala Ala Thr  Leu Thr Glu Val Ala  Asn Gly Ile 
    1775                 1780                 1785             


Glu Ser  Leu Gly Val Lys Pro  Asp Leu Pro Pro Pro  Pro Ser Lys 
    1790                 1795                 1800             


Ala Pro  Met Lys Lys Glu Asn  Gln Trp Phe Asp Val  Gly Val Ile 
    1805                 1810                 1815             


Lys Gly  Thr Asn Val Met Val  Thr His Tyr Phe Leu  Pro Pro Asp 
    1820                 1825                 1830             


Asp Ala  Val Pro Ser Asp Asp  Asp Leu Gly Thr Val  Pro Asp Tyr 
    1835                 1840                 1845             


Asn Gln  Leu Lys Lys Gln Glu  Leu Gln Pro Gly Thr  Ala Tyr Lys 
    1850                 1855                 1860             


Phe Arg  Val Ala Gly Ile Asn  Ala Cys Gly Arg Gly  Pro Phe Ser 
    1865                 1870                 1875             


Glu Ile  Ser Ala Phe Lys Thr  Cys Leu Pro Gly Phe  Pro Gly Ala 
    1880                 1885                 1890             


Pro Cys  Ala Ile Lys Ile Ser  Lys Ser Pro Asp Gly  Ala His Leu 
    1895                 1900                 1905             


Thr Trp  Glu Pro Pro Ser Val  Thr Ser Gly Lys Ile  Ile Glu Tyr 
    1910                 1915                 1920             


Ser Val  Tyr Leu Ala Ile Gln  Ser Ser Gln Ala Gly  Gly Glu Leu 
    1925                 1930                 1935             


Lys Ser  Ser Thr Pro Ala Gln  Leu Ala Phe Met Arg  Val Tyr Cys 
    1940                 1945                 1950             


Gly Pro  Ser Pro Ser Cys Leu  Val Gln Ser Ser Ser  Leu Ser Asn 
    1955                 1960                 1965             


Ala His  Ile Asp Tyr Thr Thr  Lys Pro Ala Ile Ile  Phe Arg Ile 
    1970                 1975                 1980             


Ala Ala  Arg Asn Glu Lys Gly  Tyr Gly Pro Ala Thr  Gln Val Arg 
    1985                 1990                 1995             


Trp Leu  Gln Glu Thr Ser Lys  Asp Ser Ser Gly Thr  Lys Pro Ala 
    2000                 2005                 2010             


Asn Lys  Arg Pro Met Ser Ser  Pro Glu Met Lys Ser  Ala Pro Lys 
    2015                 2020                 2025             


Lys Ser  Lys Ala Asp Gly Gln  
    2030                 2035 


<210>  21
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys Asp 
1               5                   10                  15      


Asp Gln Val Lys Lys Ile Asp Lys Tyr Leu Tyr Ala Met Arg Leu Ser 
            20                  25                  30          


Asp Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg Lys Glu Met Lys 
        35                  40                  45              


Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu Lys Gly Asp Phe 
65                  70                  75                  80  


Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile Leu Arg Val Gln 
                85                  90                  95      


Val Asn His Glu Lys Asn Gln Asn Val His Met Glu Ser Glu Val Tyr 
            100                 105                 110         


Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser Gln Leu Phe Asp 
        115                 120                 125             


His Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys Arg Lys Ile Lys 
    130                 135                 140                 


Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
145                 150                 155                 160 


Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr Lys Arg Phe Lys 
                165                 170                 175     


Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu Leu Asn Lys Ala 
            180                 185                 190         


Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val Ala Val Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp Gln His Cys 
    210                 215                 220                 


Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Glu Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met Tyr Leu Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Gly Leu Leu Phe 
305                 310                 315                 320 


Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly Lys Phe Asn Thr 
                325                 330                 335     


Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly Leu His Asn Ala 
            340                 345                 350         


Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser Asp Asp Asp Cys 
        355                 360                 365             


Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn 
    370                 375                 380                 


Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg Leu Arg Asp Asn 
385                 390                 395                 400 


Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val Asp Gly Ser Leu 
                405                 410                 415     


Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His Lys Thr Leu Arg 
            420                 425                 430         


Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu Ser Glu Ser Gly 
        435                 440                 445             


Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
    450                 455                 460                 


Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His Phe His Leu Thr 
465                 470                 475                 480 


Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg Ala Glu Met Glu 
                485                 490                 495     


Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val Val Lys Met Leu 
            500                 505                 510         


Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu Asn Gly Asp Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys 
    530                 535                 540                 


Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His Asn Lys Ile Tyr 
545                 550                 555                 560 


Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp 
                565                 570                 575     


His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr Met Gly Ile Lys 
            580                 585                 590         


Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
        595                 600                 605             


Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr Lys Gly Phe Lys 
    610                 615                 620                 


Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu Leu Arg Asp Ala 
625                 630                 635                 640 


Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                645                 650                 655     


Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu Glu Pro Thr Cys 
            660                 665                 670         


Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
        675                 680                 685             


Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln Gly Gln Met Cys 
    690                 695                 700                 


Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
705                 710                 715                 720 


Ile Arg Thr His Tyr Asp Arg Leu Val Asp Glu Tyr Ser Leu Asn Ala 
                725                 730                 735     


Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
            740                 745                 750         


Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys Gly Phe Leu Phe 
        755                 760                 765             


Arg Gly Gln Ile Ser Glu Thr Leu Lys Thr Arg Gly Ile Phe Glu Thr 
    770                 775                 780                 


Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val 
785                 790                 795                 800 


Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr Cys Asp Asp Ser 
                805                 810                 815     


Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg Arg Ala Ala Gln 
            820                 825                 830         


Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys Ile Arg Glu Asn 
        835                 840                 845             


Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val Asp Gly Thr Leu 
    850                 855                 860                 


Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His Gln Thr Val Lys 
865                 870                 875                 880 


Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu Ser Glu Asp Gly 
                885                 890                 895     


Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly Val Arg Leu Arg 
            900                 905                 910         


Thr Glu Ala Ser Ser 
        915         


<210>  22
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu 
1               5                   10                  15      


Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu 
            20                  25                  30          


Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu 
        35                  40                  45              


Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu 
    50                  55                  60                  


Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu 
65                  70                  75                  80  


Ile Pro Asn Lys Gln Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile 
                85                  90                  95      


Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys 
            100                 105                 110         


Ser Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile 
        115                 120                 125             


Ser Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val 
    130                 135                 140                 


Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr 
145                 150                 155                 160 


Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr 
                165                 170                 175     


Gly Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu 
            180                 185                 190         


Asp Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys 
        195                 200                 205             


Lys His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys 
    210                 215                 220                 


Glu Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp 
225                 230                 235                 240 


Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro 
                245                 250                 255     


Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly 
            260                 265                 270         


Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu 
        275                 280                 285             


Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile 
    290                 295                 300                 


Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp 
305                 310                 315                 320 


Glu Asp His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu Glu 
                325                 330                 335     


Phe Arg Ala Leu Leu Phe Val Pro Arg Arg Ala Pro Phe Asp Leu Phe 
            340                 345                 350         


Glu Asn Arg Lys Lys Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg Val 
        355                 360                 365             


Phe Ile Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe 
    370                 375                 380                 


Ile Arg Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg 
385                 390                 395                 400 


Glu Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu 
                405                 410                 415     


Val Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu 
            420                 425                 430         


Asn Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly 
        435                 440                 445             


Ile His Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg 
    450                 455                 460                 


Tyr Tyr Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr 
465                 470                 475                 480 


Cys Thr Arg Met Lys Glu Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly 
                485                 490                 495     


Glu Thr Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Arg 
            500                 505                 510         


Lys His Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr 
        515                 520                 525             


Cys Val Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser Val 
    530                 535                 540                 


Thr Lys Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys 
545                 550                 555                 560 


Gln Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu Cys Lys Ile Met Lys 
                565                 570                 575     


Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn Arg Leu 
            580                 585                 590         


Val Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala 
        595                 600                 605             


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr 
    610                 615                 620                 


Met Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro Asp His 
625                 630                 635                 640 


Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp 
                645                 650                 655     


Lys Ser Val Lys Asp Leu Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu 
            660                 665                 670         


Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn Arg Ile 
        675                 680                 685             


Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr 
    690                 695                 700                 


Ala Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro Leu Glu 
705                 710                 715                 720 


Gly Asp Asp Asp Thr Ser Arg Met Glu Glu Val Asp 
                725                 730         


<210>  23
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Met Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210>  24
<211>  1242
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Ser Pro Pro Glu Ser Asp Gly Phe Ser Asp Val Arg Lys Val 
1               5                   10                  15      


Gly Tyr Leu Arg Lys Pro Lys Ser Met His Lys Arg Phe Phe Val Leu 
            20                  25                  30          


Arg Ala Ala Ser Glu Ala Gly Gly Pro Ala Arg Leu Glu Tyr Tyr Glu 
        35                  40                  45              


Asn Glu Lys Lys Trp Arg His Lys Ser Ser Ala Pro Lys Arg Ser Ile 
    50                  55                  60                  


Pro Leu Glu Ser Cys Phe Asn Ile Asn Lys Arg Ala Asp Ser Lys Asn 
65                  70                  75                  80  


Lys His Leu Val Ala Leu Tyr Thr Arg Asp Glu His Phe Ala Ile Ala 
                85                  90                  95      


Ala Asp Ser Glu Ala Glu Gln Asp Ser Trp Tyr Gln Ala Leu Leu Gln 
            100                 105                 110         


Leu His Asn Arg Ala Lys Gly His His Asp Gly Ala Ala Ala Leu Gly 
        115                 120                 125             


Ala Gly Gly Gly Gly Gly Ser Cys Ser Gly Ser Ser Gly Leu Gly Glu 
    130                 135                 140                 


Ala Gly Glu Asp Leu Ser Tyr Gly Asp Val Pro Pro Gly Pro Ala Phe 
145                 150                 155                 160 


Lys Glu Val Trp Gln Val Ile Leu Lys Pro Lys Gly Leu Gly Gln Thr 
                165                 170                 175     


Lys Asn Leu Ile Gly Ile Tyr Arg Leu Cys Leu Thr Ser Lys Thr Ile 
            180                 185                 190         


Ser Phe Val Lys Leu Asn Ser Glu Ala Ala Ala Val Val Leu Gln Leu 
        195                 200                 205             


Met Asn Ile Arg Arg Cys Gly His Ser Glu Asn Phe Phe Phe Ile Glu 
    210                 215                 220                 


Val Gly Arg Ser Ala Val Thr Gly Pro Gly Glu Phe Trp Met Gln Val 
225                 230                 235                 240 


Asp Asp Ser Val Val Ala Gln Asn Met His Glu Thr Ile Leu Glu Ala 
                245                 250                 255     


Met Arg Ala Met Ser Asp Glu Phe Arg Pro Arg Ser Lys Ser Gln Ser 
            260                 265                 270         


Ser Ser Asn Cys Ser Asn Pro Ile Ser Val Pro Leu Arg Arg His His 
        275                 280                 285             


Leu Asn Asn Pro Pro Pro Ser Gln Val Gly Leu Thr Arg Arg Ser Arg 
    290                 295                 300                 


Thr Glu Ser Ile Thr Ala Thr Ser Pro Ala Ser Met Val Gly Gly Lys 
305                 310                 315                 320 


Pro Gly Ser Phe Arg Val Arg Ala Ser Ser Asp Gly Glu Gly Thr Met 
                325                 330                 335     


Ser Arg Pro Ala Ser Val Asp Gly Ser Pro Val Ser Pro Ser Thr Asn 
            340                 345                 350         


Arg Thr His Ala His Arg His Arg Gly Ser Ala Arg Leu His Pro Pro 
        355                 360                 365             


Leu Asn His Ser Arg Ser Ile Pro Met Pro Ala Ser Arg Cys Ser Pro 
    370                 375                 380                 


Ser Ala Thr Ser Pro Val Ser Leu Ser Ser Ser Ser Thr Ser Gly His 
385                 390                 395                 400 


Gly Ser Thr Ser Asp Cys Leu Phe Pro Arg Arg Ser Ser Ala Ser Val 
                405                 410                 415     


Ser Gly Ser Pro Ser Asp Gly Gly Phe Ile Ser Ser Asp Glu Tyr Gly 
            420                 425                 430         


Ser Ser Pro Cys Asp Phe Arg Ser Ser Phe Arg Ser Val Thr Pro Asp 
        435                 440                 445             


Ser Leu Gly His Thr Pro Pro Ala Arg Gly Glu Glu Glu Leu Ser Asn 
    450                 455                 460                 


Tyr Ile Cys Met Gly Gly Lys Gly Pro Ser Thr Leu Thr Ala Pro Asn 
465                 470                 475                 480 


Gly His Tyr Ile Leu Ser Arg Gly Gly Asn Gly His Arg Cys Thr Pro 
                485                 490                 495     


Gly Thr Gly Leu Gly Thr Ser Pro Ala Leu Ala Gly Asp Glu Ala Ala 
            500                 505                 510         


Ser Ala Ala Asp Leu Asp Asn Arg Phe Arg Lys Arg Thr His Ser Ala 
        515                 520                 525             


Gly Thr Ser Pro Thr Ile Thr His Gln Lys Thr Pro Ser Gln Ser Ser 
    530                 535                 540                 


Val Ala Ser Ile Glu Glu Tyr Thr Glu Met Met Pro Ala Tyr Pro Pro 
545                 550                 555                 560 


Gly Gly Gly Ser Gly Gly Arg Leu Pro Gly His Arg His Ser Ala Phe 
                565                 570                 575     


Val Pro Thr Arg Ser Tyr Pro Glu Glu Gly Leu Glu Met His Pro Leu 
            580                 585                 590         


Glu Arg Arg Gly Gly His His Arg Pro Asp Ser Ser Thr Leu His Thr 
        595                 600                 605             


Asp Asp Gly Tyr Met Pro Met Ser Pro Gly Val Ala Pro Val Pro Ser 
    610                 615                 620                 


Gly Arg Lys Gly Ser Gly Asp Tyr Met Pro Met Ser Pro Lys Ser Val 
625                 630                 635                 640 


Ser Ala Pro Gln Gln Ile Ile Asn Pro Ile Arg Arg His Pro Gln Arg 
                645                 650                 655     


Val Asp Pro Asn Gly Tyr Met Met Met Ser Pro Ser Gly Gly Cys Ser 
            660                 665                 670         


Pro Asp Ile Gly Gly Gly Pro Ser Ser Ser Ser Ser Ser Ser Asn Ala 
        675                 680                 685             


Val Pro Ser Gly Thr Ser Tyr Gly Lys Leu Trp Thr Asn Gly Val Gly 
    690                 695                 700                 


Gly His His Ser His Val Leu Pro His Pro Lys Pro Pro Val Glu Ser 
705                 710                 715                 720 


Ser Gly Gly Lys Leu Leu Pro Cys Thr Gly Asp Tyr Met Asn Met Ser 
                725                 730                 735     


Pro Val Gly Asp Ser Asn Thr Ser Ser Pro Ser Asp Cys Tyr Tyr Gly 
            740                 745                 750         


Pro Glu Asp Pro Gln His Lys Pro Val Leu Ser Tyr Tyr Ser Leu Pro 
        755                 760                 765             


Arg Ser Phe Lys His Thr Gln Arg Pro Gly Glu Pro Glu Glu Gly Ala 
    770                 775                 780                 


Arg His Gln His Leu Arg Leu Ser Thr Ser Ser Gly Arg Leu Leu Tyr 
785                 790                 795                 800 


Ala Ala Thr Ala Asp Asp Ser Ser Ser Ser Thr Ser Ser Asp Ser Leu 
                805                 810                 815     


Gly Gly Gly Tyr Cys Gly Ala Arg Leu Glu Pro Ser Leu Pro His Pro 
            820                 825                 830         


His His Gln Val Leu Gln Pro His Leu Pro Arg Lys Val Asp Thr Ala 
        835                 840                 845             


Ala Gln Thr Asn Ser Arg Leu Ala Arg Pro Thr Arg Leu Ser Leu Gly 
    850                 855                 860                 


Asp Pro Lys Ala Ser Thr Leu Pro Arg Ala Arg Glu Gln Gln Gln Gln 
865                 870                 875                 880 


Gln Gln Pro Leu Leu His Pro Pro Glu Pro Lys Ser Pro Gly Glu Tyr 
                885                 890                 895     


Val Asn Ile Glu Phe Gly Ser Asp Gln Ser Gly Tyr Leu Ser Gly Pro 
            900                 905                 910         


Val Ala Phe His Ser Ser Pro Ser Val Arg Cys Pro Ser Gln Leu Gln 
        915                 920                 925             


Pro Ala Pro Arg Glu Glu Glu Thr Gly Thr Glu Glu Tyr Met Lys Met 
    930                 935                 940                 


Asp Leu Gly Pro Gly Arg Arg Ala Ala Trp Gln Glu Ser Thr Gly Val 
945                 950                 955                 960 


Glu Met Gly Arg Leu Gly Pro Ala Pro Pro Gly Ala Ala Ser Ile Cys 
                965                 970                 975     


Arg Pro Thr Arg Ala Val Pro Ser Ser Arg Gly Asp Tyr Met Thr Met 
            980                 985                 990         


Gln Met Ser Cys Pro Arg Gln Ser  Tyr Val Asp Thr Ser  Pro Ala Ala 
        995                 1000                 1005             


Pro Val  Ser Tyr Ala Asp Met  Arg Thr Gly Ile Ala  Ala Glu Glu 
    1010                 1015                 1020             


Val Ser  Leu Pro Arg Ala Thr  Met Ala Ala Ala Ser  Ser Ser Ser 
    1025                 1030                 1035             


Ala Ala  Ser Ala Ser Pro Thr  Gly Pro Gln Gly Ala  Ala Glu Leu 
    1040                 1045                 1050             


Ala Ala  His Ser Ser Leu Leu  Gly Gly Pro Gln Gly  Pro Gly Gly 
    1055                 1060                 1065             


Met Ser  Ala Phe Thr Arg Val  Asn Leu Ser Pro Asn  Arg Asn Gln 
    1070                 1075                 1080             


Ser Ala  Lys Val Ile Arg Ala  Asp Pro Gln Gly Cys  Arg Arg Arg 
    1085                 1090                 1095             


His Ser  Ser Glu Thr Phe Ser  Ser Thr Pro Ser Ala  Thr Arg Val 
    1100                 1105                 1110             


Gly Asn  Thr Val Pro Phe Gly  Ala Gly Ala Ala Val  Gly Gly Gly 
    1115                 1120                 1125             


Gly Gly  Ser Ser Ser Ser Ser  Glu Asp Val Lys Arg  His Ser Ser 
    1130                 1135                 1140             


Ala Ser  Phe Glu Asn Val Trp  Leu Arg Pro Gly Glu  Leu Gly Gly 
    1145                 1150                 1155             


Ala Pro  Lys Glu Pro Ala Lys  Leu Cys Gly Ala Ala  Gly Gly Leu 
    1160                 1165                 1170             


Glu Asn  Gly Leu Asn Tyr Ile  Asp Leu Asp Leu Val  Lys Asp Phe 
    1175                 1180                 1185             


Lys Gln  Cys Pro Gln Glu Cys  Thr Pro Glu Pro Gln  Pro Pro Pro 
    1190                 1195                 1200             


Pro Pro  Pro Pro His Gln Pro  Leu Gly Ser Gly Glu  Ser Ser Ser 
    1205                 1210                 1215             


Thr Arg  Arg Ser Ser Glu Asp  Leu Ser Ala Tyr Ala  Ser Ile Ser 
    1220                 1225                 1230             


Phe Gln  Lys Gln Pro Glu Asp  Arg Gln 
    1235                 1240         


<210>  25
<211>  2758
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
65                  70                  75                  80  


Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                85                  90                  95      


Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
            100                 105                 110         


Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                165                 170                 175     


Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
        195                 200                 205             


Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
    210                 215                 220                 


Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                245                 250                 255     


Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
305                 310                 315                 320 


Asp Phe Glu Glu Glu Cys Leu Glu Phe Gln Pro Ser Val Asp Pro Asp 
                325                 330                 335     


Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met Val 
            340                 345                 350         


Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile Phe 
        355                 360                 365             


Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro Arg 
    370                 375                 380                 


Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val His 
385                 390                 395                 400 


Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met Leu 
                405                 410                 415     


Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala Ile 
            420                 425                 430         


Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn Asp 
        435                 440                 445             


Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly Thr 
    450                 455                 460                 


Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp Leu 
465                 470                 475                 480 


Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu Glu 
                485                 490                 495     


Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu 
            500                 505                 510         


Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe Thr 
        515                 520                 525             


Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp Gln 
    530                 535                 540                 


Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val Leu 
545                 550                 555                 560 


Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala Lys 
                565                 570                 575     


Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala Glu 
            580                 585                 590         


Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                 600                 605             


His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg Lys 
    610                 615                 620                 


Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                 630                 635                 640 


Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala Val 
                645                 650                 655     


Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val Leu 
            660                 665                 670         


Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala Leu 
        675                 680                 685             


Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp Ser 
    690                 695                 700                 


Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp Ala 
705                 710                 715                 720 


Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg Tyr 
                725                 730                 735     


Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala 
            740                 745                 750         


Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg Cys 
        755                 760                 765             


Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys Arg 
    770                 775                 780                 


Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val Thr 
785                 790                 795                 800 


Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile Ala 
                805                 810                 815     


Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys Glu 
            820                 825                 830         


Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp Val 
        835                 840                 845             


Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu Thr 
    850                 855                 860                 


Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe Tyr 
865                 870                 875                 880 


Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile Leu 
                885                 890                 895     


Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala Lys 
            900                 905                 910         


Gly Glu Glu Asn Lys Gly Asn Asn Asp Val Glu Lys Leu Lys Ser Ser 
        915                 920                 925             


Asn Val Met Arg Ser Ile His Gly Val Gly Glu Leu Met Thr Gln Val 
    930                 935                 940                 


Val Leu Arg Gly Gly Gly Phe Leu Pro Met Thr Pro Met Ala Ala Ala 
945                 950                 955                 960 


Pro Glu Gly Asn Val Lys Gln Ala Glu Pro Glu Lys Glu Asp Ile Met 
                965                 970                 975     


Val Met Asp Thr Lys Leu Lys Ile Ile Glu Ile Leu Gln Phe Ile Leu 
            980                 985                 990         


Asn Val Arg Leu Asp Tyr Arg Ile  Ser Cys Leu Leu Cys  Ile Phe Lys 
        995                 1000                 1005             


Arg Glu  Phe Asp Glu Ser Asn  Ser Gln Thr Ser Glu  Thr Ser Ser 
    1010                 1015                 1020             


Gly Asn  Ser Ser Gln Glu Gly  Pro Ser Asn Val Pro  Gly Ala Leu 
    1025                 1030                 1035             


Asp Phe  Glu His Ile Glu Glu  Gln Ala Glu Gly Ile  Phe Gly Gly 
    1040                 1045                 1050             


Ser Glu  Glu Asn Thr Pro Leu  Asp Leu Asp Asp His  Gly Gly Arg 
    1055                 1060                 1065             


Thr Phe  Leu Arg Val Leu Leu  His Leu Thr Met His  Asp Tyr Pro 
    1070                 1075                 1080             


Pro Leu  Val Ser Gly Ala Leu  Gln Leu Leu Phe Arg  His Phe Ser 
    1085                 1090                 1095             


Gln Arg  Gln Glu Val Leu Gln  Ala Phe Lys Gln Val  Gln Leu Leu 
    1100                 1105                 1110             


Val Thr  Ser Gln Asp Val Asp  Asn Tyr Lys Gln Ile  Lys Gln Asp 
    1115                 1120                 1125             


Leu Asp  Gln Leu Arg Ser Ile  Val Glu Lys Ser Glu  Leu Trp Val 
    1130                 1135                 1140             


Tyr Lys  Gly Gln Gly Pro Asp  Glu Thr Met Asp Gly  Ala Ser Gly 
    1145                 1150                 1155             


Glu Asn  Glu His Lys Lys Thr  Glu Glu Gly Asn Asn  Lys Pro Gln 
    1160                 1165                 1170             


Lys His  Glu Ser Thr Ser Ser  Tyr Asn Tyr Arg Val  Val Lys Glu 
    1175                 1180                 1185             


Ile Leu  Ile Arg Leu Ser Lys  Leu Cys Val Gln Glu  Ser Ala Ser 
    1190                 1195                 1200             


Val Arg  Lys Ser Arg Lys Gln  Gln Gln Arg Leu Leu  Arg Asn Met 
    1205                 1210                 1215             


Gly Ala  His Ala Val Val Leu  Glu Leu Leu Gln Ile  Pro Tyr Glu 
    1220                 1225                 1230             


Lys Ala  Glu Asp Thr Lys Met  Gln Glu Ile Met Arg  Leu Ala His 
    1235                 1240                 1245             


Glu Phe  Leu Gln Asn Phe Cys  Ala Gly Asn Gln Gln  Asn Gln Ala 
    1250                 1255                 1260             


Leu Leu  His Lys His Ile Asn  Leu Phe Leu Asn Pro  Gly Ile Leu 
    1265                 1270                 1275             


Glu Ala  Val Thr Met Gln His  Ile Phe Met Asn Asn  Phe Gln Leu 
    1280                 1285                 1290             


Cys Ser  Glu Ile Asn Glu Arg  Val Val Gln His Phe  Val His Cys 
    1295                 1300                 1305             


Ile Glu  Thr His Gly Arg Asn  Val Gln Tyr Ile Lys  Phe Leu Gln 
    1310                 1315                 1320             


Thr Ile  Val Lys Ala Glu Gly  Lys Phe Ile Lys Lys  Cys Gln Asp 
    1325                 1330                 1335             


Met Val  Met Ala Glu Leu Val  Asn Ser Gly Glu Asp  Val Leu Val 
    1340                 1345                 1350             


Phe Tyr  Asn Asp Arg Ala Ser  Phe Gln Thr Leu Ile  Gln Met Met 
    1355                 1360                 1365             


Arg Ser  Glu Arg Asp Arg Met  Asp Glu Asn Ser Pro  Leu Met Tyr 
    1370                 1375                 1380             


His Ile  His Leu Val Glu Leu  Leu Ala Val Cys Thr  Glu Gly Lys 
    1385                 1390                 1395             


Asn Val  Tyr Thr Glu Ile Lys  Cys Asn Ser Leu Leu  Pro Leu Asp 
    1400                 1405                 1410             


Asp Ile  Val Arg Val Val Thr  His Glu Asp Cys Ile  Pro Glu Val 
    1415                 1420                 1425             


Lys Ile  Ala Tyr Ile Asn Phe  Leu Asn His Cys Tyr  Val Asp Thr 
    1430                 1435                 1440             


Glu Val  Glu Met Lys Glu Ile  Tyr Thr Ser Asn His  Met Trp Lys 
    1445                 1450                 1455             


Leu Phe  Glu Asn Phe Leu Val  Asp Ile Cys Arg Ala  Cys Asn Asn 
    1460                 1465                 1470             


Thr Ser  Asp Arg Lys His Ala  Asp Ser Ile Leu Glu  Lys Tyr Val 
    1475                 1480                 1485             


Thr Glu  Ile Val Met Ser Ile  Val Thr Thr Phe Phe  Ser Ser Pro 
    1490                 1495                 1500             


Phe Ser  Asp Gln Ser Thr Thr  Leu Gln Thr Arg Gln  Pro Val Phe 
    1505                 1510                 1515             


Val Gln  Leu Leu Gln Gly Val  Phe Arg Val Tyr His  Cys Asn Trp 
    1520                 1525                 1530             


Leu Met  Pro Ser Gln Lys Ala  Ser Val Glu Ser Cys  Ile Arg Val 
    1535                 1540                 1545             


Leu Ser  Asp Val Ala Lys Ser  Arg Ala Ile Ala Ile  Pro Val Asp 
    1550                 1555                 1560             


Leu Asp  Ser Gln Val Asn Asn  Leu Phe Leu Lys Ser  His Ser Ile 
    1565                 1570                 1575             


Val Gln  Lys Thr Ala Met Asn  Trp Arg Leu Ser Ala  Arg Asn Ala 
    1580                 1585                 1590             


Ala Arg  Arg Asp Ser Val Leu  Ala Ala Ser Arg Asp  Tyr Arg Asn 
    1595                 1600                 1605             


Ile Ile  Glu Arg Leu Gln Asp  Ile Val Ser Ala Leu  Glu Asp Arg 
    1610                 1615                 1620             


Leu Arg  Pro Leu Val Gln Ala  Glu Leu Ser Val Leu  Val Asp Val 
    1625                 1630                 1635             


Leu His  Arg Pro Glu Leu Leu  Phe Pro Glu Asn Thr  Asp Ala Arg 
    1640                 1645                 1650             


Arg Lys  Cys Glu Ser Gly Gly  Phe Ile Cys Lys Leu  Ile Lys His 
    1655                 1660                 1665             


Thr Lys  Gln Leu Leu Glu Glu  Asn Glu Glu Lys Leu  Cys Ile Lys 
    1670                 1675                 1680             


Val Leu  Gln Thr Leu Arg Glu  Met Met Thr Lys Asp  Arg Gly Tyr 
    1685                 1690                 1695             


Gly Glu  Lys Leu Ile Ser Ile  Asp Glu Leu Asp Asn  Ala Glu Leu 
    1700                 1705                 1710             


Pro Pro  Ala Pro Asp Ser Glu  Asn Ser Thr Glu Glu  Leu Glu Pro 
    1715                 1720                 1725             


Ser Pro  Pro Leu Arg Gln Leu  Glu Asp His Lys Arg  Gly Glu Ala 
    1730                 1735                 1740             


Leu Arg  Gln Val Leu Val Asn  Arg Tyr Tyr Gly Asn  Val Arg Pro 
    1745                 1750                 1755             


Ser Gly  Arg Arg Glu Ser Leu  Thr Ser Phe Gly Asn  Gly Pro Leu 
    1760                 1765                 1770             


Ser Ala  Gly Gly Pro Gly Lys  Pro Gly Gly Gly Gly  Gly Gly Ser 
    1775                 1780                 1785             


Gly Ser  Ser Ser Met Ser Arg  Gly Glu Met Ser Leu  Ala Glu Val 
    1790                 1795                 1800             


Gln Cys  His Leu Asp Lys Glu  Gly Ala Ser Asn Leu  Val Ile Asp 
    1805                 1810                 1815             


Leu Ile  Met Asn Ala Ser Ser  Asp Arg Val Phe His  Glu Ser Ile 
    1820                 1825                 1830             


Leu Leu  Ala Ile Ala Leu Leu  Glu Gly Gly Asn Thr  Thr Ile Gln 
    1835                 1840                 1845             


His Ser  Phe Phe Cys Arg Leu  Thr Glu Asp Lys Lys  Ser Glu Lys 
    1850                 1855                 1860             


Phe Phe  Lys Val Phe Tyr Asp  Arg Met Lys Val Ala  Gln Gln Glu 
    1865                 1870                 1875             


Ile Lys  Ala Thr Val Thr Val  Asn Thr Ser Asp Leu  Gly Asn Lys 
    1880                 1885                 1890             


Lys Lys  Asp Asp Glu Val Asp  Arg Asp Ala Pro Ser  Arg Lys Lys 
    1895                 1900                 1905             


Ala Lys  Glu Pro Thr Thr Gln  Ile Thr Glu Glu Val  Arg Asp Gln 
    1910                 1915                 1920             


Leu Leu  Glu Ala Ser Ala Ala  Thr Arg Lys Ala Phe  Thr Thr Phe 
    1925                 1930                 1935             


Arg Arg  Glu Ala Asp Pro Asp  Asp His Tyr Gln Pro  Gly Glu Gly 
    1940                 1945                 1950             


Thr Gln  Ala Thr Ala Asp Lys  Ala Lys Asp Asp Leu  Glu Met Ser 
    1955                 1960                 1965             


Ala Val  Ile Thr Ile Met Gln  Pro Ile Leu Arg Phe  Leu Gln Leu 
    1970                 1975                 1980             


Leu Cys  Glu Asn His Asn Arg  Asp Leu Gln Asn Phe  Leu Arg Cys 
    1985                 1990                 1995             


Gln Asn  Asn Lys Thr Asn Tyr  Asn Leu Val Cys Glu  Thr Leu Gln 
    2000                 2005                 2010             


Phe Leu  Asp Cys Ile Cys Gly  Ser Thr Thr Gly Gly  Leu Gly Leu 
    2015                 2020                 2025             


Leu Gly  Leu Tyr Ile Asn Glu  Lys Asn Val Ala Leu  Ile Asn Gln 
    2030                 2035                 2040             


Thr Leu  Glu Ser Leu Thr Glu  Tyr Cys Gln Gly Pro  Cys His Glu 
    2045                 2050                 2055             


Asn Gln  Asn Cys Ile Ala Thr  His Glu Ser Asn Gly  Ile Asp Ile 
    2060                 2065                 2070             


Ile Thr  Ala Leu Ile Leu Asn  Asp Ile Asn Pro Leu  Gly Lys Lys 
    2075                 2080                 2085             


Arg Met  Asp Leu Val Leu Glu  Leu Lys Asn Asn Ala  Ser Lys Leu 
    2090                 2095                 2100             


Leu Leu  Ala Ile Met Glu Ser  Arg His Asp Ser Glu  Asn Ala Glu 
    2105                 2110                 2115             


Arg Ile  Leu Tyr Asn Met Arg  Pro Lys Glu Leu Val  Glu Val Ile 
    2120                 2125                 2130             


Lys Lys  Ala Tyr Met Gln Gly  Glu Val Glu Phe Glu  Asp Gly Glu 
    2135                 2140                 2145             


Asn Gly  Glu Asp Gly Ala Ala  Ser Pro Arg Asn Val  Gly His Asn 
    2150                 2155                 2160             


Ile Tyr  Ile Leu Ala His Gln  Leu Ala Arg His Asn  Lys Glu Leu 
    2165                 2170                 2175             


Gln Ser  Met Leu Lys Pro Gly  Gly Gln Val Asp Gly  Asp Glu Ala 
    2180                 2185                 2190             


Leu Glu  Phe Tyr Ala Lys His  Thr Ala Gln Ile Glu  Ile Val Arg 
    2195                 2200                 2205             


Leu Asp  Arg Thr Met Glu Gln  Ile Val Phe Pro Val  Pro Ser Ile 
    2210                 2215                 2220             


Cys Glu  Phe Leu Thr Lys Glu  Ser Lys Leu Arg Ile  Tyr Tyr Thr 
    2225                 2230                 2235             


Thr Glu  Arg Asp Glu Gln Gly  Ser Lys Ile Asn Asp  Phe Phe Leu 
    2240                 2245                 2250             


Arg Ser  Glu Asp Leu Phe Asn  Glu Met Asn Trp Gln  Lys Lys Leu 
    2255                 2260                 2265             


Arg Ala  Gln Pro Val Leu Tyr  Trp Cys Ala Arg Asn  Met Ser Phe 
    2270                 2275                 2280             


Trp Ser  Ser Ile Ser Phe Asn  Leu Ala Val Leu Met  Asn Leu Leu 
    2285                 2290                 2295             


Val Ala  Phe Phe Tyr Pro Phe  Lys Gly Val Arg Gly  Gly Thr Leu 
    2300                 2305                 2310             


Glu Pro  His Trp Ser Gly Leu  Leu Trp Thr Ala Met  Leu Ile Ser 
    2315                 2320                 2325             


Leu Ala  Ile Val Ile Ala Leu  Pro Lys Pro His Gly  Ile Arg Ala 
    2330                 2335                 2340             


Leu Ile  Ala Ser Thr Ile Leu  Arg Leu Ile Phe Ser  Val Gly Leu 
    2345                 2350                 2355             


Gln Pro  Thr Leu Phe Leu Leu  Gly Ala Phe Asn Val  Cys Asn Lys 
    2360                 2365                 2370             


Ile Ile  Phe Leu Met Ser Phe  Val Gly Asn Cys Gly  Thr Phe Thr 
    2375                 2380                 2385             


Arg Gly  Tyr Arg Ala Met Val  Leu Asp Val Glu Phe  Leu Tyr His 
    2390                 2395                 2400             


Leu Leu  Tyr Leu Val Ile Cys  Ala Met Gly Leu Phe  Val His Glu 
    2405                 2410                 2415             


Phe Phe  Tyr Ser Leu Leu Leu  Phe Asp Leu Val Tyr  Arg Glu Glu 
    2420                 2425                 2430             


Thr Leu  Leu Asn Val Ile Lys  Ser Val Thr Arg Asn  Gly Arg Ser 
    2435                 2440                 2445             


Ile Ile  Leu Thr Ala Val Leu  Ala Leu Ile Leu Val  Tyr Leu Phe 
    2450                 2455                 2460             


Ser Ile  Val Gly Tyr Leu Phe  Phe Lys Asp Asp Phe  Ile Leu Glu 
    2465                 2470                 2475             


Val Asp  Arg Leu Pro Asn Glu  Thr Ala Val Pro Glu  Thr Gly Glu 
    2480                 2485                 2490             


Ser Leu  Ala Ser Glu Phe Leu  Phe Ser Asp Val Cys  Arg Val Glu 
    2495                 2500                 2505             


Ser Gly  Glu Asn Cys Ser Ser  Pro Ala Pro Arg Glu  Glu Leu Val 
    2510                 2515                 2520             


Pro Ala  Glu Glu Thr Glu Gln  Asp Lys Glu His Thr  Cys Glu Thr 
    2525                 2530                 2535             


Leu Leu  Met Cys Ile Val Thr  Val Leu Ser His Gly  Leu Arg Ser 
    2540                 2545                 2550             


Gly Gly  Gly Val Gly Asp Val  Leu Arg Lys Pro Ser  Lys Glu Glu 
    2555                 2560                 2565             


Pro Leu  Phe Ala Ala Arg Val  Ile Tyr Asp Leu Leu  Phe Phe Phe 
    2570                 2575                 2580             


Met Val  Ile Ile Ile Val Leu  Asn Leu Ile Phe Gly  Val Ile Ile 
    2585                 2590                 2595             


Asp Thr  Phe Ala Asp Leu Arg  Ser Glu Lys Gln Lys  Lys Glu Glu 
    2600                 2605                 2610             


Ile Leu  Lys Thr Thr Cys Phe  Ile Cys Gly Leu Glu  Arg Asp Lys 
    2615                 2620                 2625             


Phe Asp  Asn Lys Thr Val Thr  Phe Glu Glu His Ile  Lys Glu Glu 
    2630                 2635                 2640             


His Asn  Met Trp His Tyr Leu  Cys Phe Ile Val Leu  Val Lys Val 
    2645                 2650                 2655             


Lys Asp  Ser Thr Glu Tyr Thr  Gly Pro Glu Ser Tyr  Val Ala Glu 
    2660                 2665                 2670             


Met Ile  Lys Glu Arg Asn Leu  Asp Trp Phe Pro Arg  Met Arg Ala 
    2675                 2680                 2685             


Met Ser  Leu Val Ser Ser Asp  Ser Glu Gly Glu Gln  Asn Glu Leu 
    2690                 2695                 2700             


Arg Asn  Leu Gln Glu Lys Leu  Glu Ser Thr Met Lys  Leu Val Thr 
    2705                 2710                 2715             


Asn Leu  Ser Gly Gln Leu Ser  Glu Leu Lys Asp Gln  Met Thr Glu 
    2720                 2725                 2730             


Gln Arg  Lys Gln Lys Gln Arg  Ile Gly Leu Leu Gly  His Pro Pro 
    2735                 2740                 2745             


His Met  Asn Val Asn Pro Gln  Gln Pro Ala 
    2750                 2755             


<210>  26
<211>  1236
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ile Leu Ile Asn Pro Gly Asn His Leu Lys Ile Gln Glu 
                645                 650                 655     


Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys Glu Val Lys Arg 
            660                 665                 670         


Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile Thr Asp Pro Lys 
        675                 680                 685             


Arg Ile Lys Lys Cys Gly Cys Lys Arg Pro Lys Met Ser Ile Tyr Lys 
    690                 695                 700                 


Arg Met Arg Arg Ala Cys Cys Phe Asp Cys Gly Arg Ser Glu Arg Asp 
705                 710                 715                 720 


Cys Ser Cys Met Ser Gly Arg Val Arg Gly Asn Val Asp Thr Leu Glu 
                725                 730                 735     


Arg Ala Phe Pro Leu Ser Ser Val Ser Val Asn Asp Cys Ser Thr Ser 
            740                 745                 750         


Phe Arg Ala Phe Glu Asp Glu Gln Pro Ser Thr Leu Ser Pro Lys Lys 
        755                 760                 765             


Lys Gln Arg Asn Gly Gly Met Arg Asn Ser Pro Asn Thr Ser Pro Lys 
    770                 775                 780                 


Leu Met Arg His Asp Pro Leu Leu Ile Pro Gly Asn Asp Gln Ile Asp 
785                 790                 795                 800 


Asn Met Asp Ser Asn Val Lys Lys Tyr Asp Ser Thr Gly Met Phe His 
                805                 810                 815     


Trp Cys Ala Pro Lys Glu Ile Glu Lys Val Ile Leu Thr Arg Ser Glu 
            820                 825                 830         


Ala Ala Met Thr Val Leu Ser Gly His Val Val Val Cys Ile Phe Gly 
        835                 840                 845             


Asp Val Ser Ser Ala Leu Ile Gly Leu Arg Asn Leu Val Met Pro Leu 
    850                 855                 860                 


Arg Ala Ser Asn Phe His Tyr His Glu Leu Lys His Ile Val Phe Val 
865                 870                 875                 880 


Gly Ser Ile Glu Tyr Leu Lys Arg Glu Trp Glu Thr Leu His Asn Phe 
                885                 890                 895     


Pro Lys Val Ser Ile Leu Pro Gly Thr Pro Leu Ser Arg Ala Asp Leu 
            900                 905                 910         


Arg Ala Val Asn Ile Asn Leu Cys Asp Met Cys Val Ile Leu Ser Ala 
        915                 920                 925             


Asn Gln Asn Asn Ile Asp Asp Thr Ser Leu Gln Asp Lys Glu Cys Ile 
    930                 935                 940                 


Leu Ala Ser Leu Asn Ile Lys Ser Met Gln Phe Asp Asp Ser Ile Gly 
945                 950                 955                 960 


Val Leu Gln Ala Asn Ser Gln Gly Phe Thr Pro Pro Gly Met Asp Arg 
                965                 970                 975     


Ser Ser Pro Asp Asn Ser Pro Val His Gly Met Leu Arg Gln Pro Ser 
            980                 985                 990         


Ile Thr Thr Gly Val Asn Ile Pro  Ile Ile Thr Glu Leu  Val Asn Asp 
        995                 1000                 1005             


Thr Asn  Val Gln Phe Leu Asp  Gln Asp Asp Asp Asp  Asp Pro Asp 
    1010                 1015                 1020             


Thr Glu  Leu Tyr Leu Thr Gln  Pro Phe Ala Cys Gly  Thr Ala Phe 
    1025                 1030                 1035             


Ala Val  Ser Val Leu Asp Ser  Leu Met Ser Ala Thr  Tyr Phe Asn 
    1040                 1045                 1050             


Asp Asn  Ile Leu Thr Leu Ile  Arg Thr Leu Val Thr  Gly Gly Ala 
    1055                 1060                 1065             


Thr Pro  Glu Leu Glu Ala Leu  Ile Ala Glu Glu Asn  Ala Leu Arg 
    1070                 1075                 1080             


Gly Gly  Tyr Ser Thr Pro Gln  Thr Leu Ala Asn Arg  Asp Arg Cys 
    1085                 1090                 1095             


Arg Val  Ala Gln Leu Ala Leu  Leu Asp Gly Pro Phe  Ala Asp Leu 
    1100                 1105                 1110             


Gly Asp  Gly Gly Cys Tyr Gly  Asp Leu Phe Cys Lys  Ala Leu Lys 
    1115                 1120                 1125             


Thr Tyr  Asn Met Leu Cys Phe  Gly Ile Tyr Arg Leu  Arg Asp Ala 
    1130                 1135                 1140             


His Leu  Ser Thr Pro Ser Gln  Cys Thr Lys Arg Tyr  Val Ile Thr 
    1145                 1150                 1155             


Asn Pro  Pro Tyr Glu Phe Glu  Leu Val Pro Thr Asp  Leu Ile Phe 
    1160                 1165                 1170             


Cys Leu  Met Gln Phe Asp His  Asn Ala Gly Gln Ser  Arg Ala Ser 
    1175                 1180                 1185             


Leu Ser  His Ser Ser His Ser  Ser Gln Ser Ser Ser  Lys Lys Ser 
    1190                 1195                 1200             


Ser Ser  Val His Ser Ile Pro  Ser Thr Ala Asn Arg  Gln Asn Arg 
    1205                 1210                 1215             


Pro Lys  Ser Arg Glu Ser Arg  Asp Lys Gln Lys Tyr  Val Gln Glu 
    1220                 1225                 1230             


Glu Arg  Leu 
    1235     


<210>  27
<211>  1946
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Val Glu Ser Cys Leu Leu Thr Phe Arg Ala Phe Phe Trp Trp Ile 
1               5                   10                  15      


Ala Leu Ile Lys Met Asp Leu Ser Asp Leu Gly Glu Ala Ala Ala Phe 
            20                  25                  30          


Leu Arg Arg Ser Glu Ala Glu Leu Leu Leu Leu Gln Ala Thr Ala Leu 
        35                  40                  45              


Asp Gly Lys Lys Lys Cys Trp Ile Pro Asp Gly Glu Asn Ala Tyr Ile 
    50                  55                  60                  


Glu Ala Glu Val Lys Gly Ser Glu Asp Asp Gly Thr Val Ile Val Glu 
65                  70                  75                  80  


Thr Ala Asp Gly Glu Ser Leu Ser Ile Lys Glu Asp Lys Ile Gln Gln 
                85                  90                  95      


Met Asn Pro Pro Glu Phe Glu Met Ile Glu Asp Met Ala Met Leu Thr 
            100                 105                 110         


His Leu Asn Glu Ala Ser Val Leu His Thr Leu Lys Arg Arg Tyr Gly 
        115                 120                 125             


Gln Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Ile Asn 
    130                 135                 140                 


Pro Tyr Lys Trp Leu Pro Val Tyr Gln Lys Glu Val Met Ala Ala Tyr 
145                 150                 155                 160 


Lys Gly Lys Arg Arg Ser Glu Ala Pro Pro His Ile Phe Ala Val Ala 
                165                 170                 175     


Asn Asn Ala Phe Gln Asp Met Leu His Asn Arg Glu Asn Gln Ser Ile 
            180                 185                 190         


Leu Phe Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Ser Lys His 
        195                 200                 205             


Ile Ile Gln Tyr Phe Ala Thr Ile Ala Ala Met Ile Glu Ser Arg Lys 
    210                 215                 220                 


Lys Gln Gly Ala Leu Glu Asp Gln Ile Met Gln Ala Asn Thr Ile Leu 
225                 230                 235                 240 


Glu Ala Phe Gly Asn Ala Lys Thr Leu Arg Asn Asp Asn Ser Ser Arg 
                245                 250                 255     


Phe Gly Lys Phe Ile Arg Met His Phe Gly Ala Arg Gly Met Leu Ser 
            260                 265                 270         


Ser Val Asp Ile Asp Ile Tyr Leu Leu Glu Lys Ser Arg Val Ile Phe 
        275                 280                 285             


Gln Gln Ala Gly Glu Arg Asn Tyr His Ile Phe Tyr Gln Ile Leu Ser 
    290                 295                 300                 


Gly Gln Lys Glu Leu His Asp Leu Leu Leu Val Ser Ala Asn Pro Ser 
305                 310                 315                 320 


Asp Phe His Phe Cys Ser Cys Gly Ala Val Thr Val Glu Ser Leu Asp 
                325                 330                 335     


Asp Ala Glu Glu Leu Leu Ala Thr Glu Gln Ala Met Asp Ile Leu Gly 
            340                 345                 350         


Phe Leu Pro Asp Glu Lys Tyr Gly Cys Tyr Lys Leu Thr Gly Ala Ile 
        355                 360                 365             


Met His Phe Gly Asn Met Lys Phe Lys Gln Lys Pro Arg Glu Glu Gln 
    370                 375                 380                 


Leu Glu Ala Asp Gly Thr Glu Asn Ala Asp Lys Ala Ala Phe Leu Met 
385                 390                 395                 400 


Gly Ile Asn Ser Ser Glu Leu Val Lys Cys Leu Ile His Pro Arg Ile 
                405                 410                 415     


Lys Val Gly Asn Glu Tyr Val Thr Arg Gly Gln Thr Ile Glu Gln Val 
            420                 425                 430         


Thr Cys Ala Val Gly Ala Leu Ser Lys Ser Met Tyr Glu Arg Met Phe 
        435                 440                 445             


Lys Trp Leu Val Ala Arg Ile Asn Arg Ala Leu Asp Ala Lys Leu Ser 
    450                 455                 460                 


Arg Gln Phe Phe Ile Gly Ile Leu Asp Ile Thr Gly Phe Glu Ile Leu 
465                 470                 475                 480 


Glu Tyr Asn Ser Leu Glu Gln Leu Cys Ile Asn Phe Thr Asn Glu Lys 
                485                 490                 495     


Leu Gln Gln Phe Phe Asn Trp His Met Phe Val Leu Glu Gln Glu Glu 
            500                 505                 510         


Tyr Lys Lys Glu Ser Ile Glu Trp Val Ser Ile Gly Phe Gly Leu Asp 
        515                 520                 525             


Leu Gln Ala Cys Ile Asp Leu Ile Glu Lys Pro Met Gly Ile Leu Ser 
    530                 535                 540                 


Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala Thr Asp Leu Thr Phe 
545                 550                 555                 560 


Lys Thr Lys Leu Phe Asp Asn His Phe Gly Lys Ser Val His Leu Gln 
                565                 570                 575     


Lys Pro Lys Pro Asp Lys Lys Lys Phe Glu Ala His Phe Glu Leu Val 
            580                 585                 590         


His Tyr Ala Gly Val Val Pro Tyr Asn Ile Ser Gly Trp Leu Glu Lys 
        595                 600                 605             


Asn Lys Asp Leu Leu Asn Glu Thr Val Val Ala Val Phe Gln Lys Ser 
    610                 615                 620                 


Ser Asn Arg Leu Leu Ala Ser Leu Phe Glu Asn Tyr Met Ser Thr Asp 
625                 630                 635                 640 


Ser Ala Ile Pro Phe Gly Glu Lys Lys Arg Lys Lys Gly Ala Ser Phe 
                645                 650                 655     


Gln Thr Val Ala Ser Leu His Lys Glu Asn Leu Asn Lys Leu Met Thr 
            660                 665                 670         


Asn Leu Lys Ser Thr Ala Pro His Phe Val Arg Cys Ile Asn Pro Asn 
        675                 680                 685             


Val Asn Lys Ile Pro Gly Ile Leu Asp Pro Tyr Leu Val Leu Gln Gln 
    690                 695                 700                 


Leu Arg Cys Asn Gly Val Leu Glu Gly Thr Arg Ile Cys Arg Glu Gly 
705                 710                 715                 720 


Phe Pro Asn Arg Leu Gln Tyr Ala Asp Phe Lys Gln Arg Tyr Cys Ile 
                725                 730                 735     


Leu Asn Pro Arg Thr Phe Pro Lys Ser Lys Phe Val Ser Ser Arg Lys 
            740                 745                 750         


Ala Ala Glu Glu Leu Leu Gly Ser Leu Glu Ile Asp His Thr Gln Tyr 
        755                 760                 765             


Arg Phe Gly Ile Thr Lys Val Phe Phe Lys Ala Gly Phe Leu Gly Gln 
    770                 775                 780                 


Leu Glu Ala Ile Arg Asp Glu Arg Leu Ser Lys Val Phe Thr Leu Phe 
785                 790                 795                 800 


Gln Ala Arg Ala Gln Gly Lys Leu Met Arg Ile Lys Phe Gln Lys Ile 
                805                 810                 815     


Leu Glu Glu Arg Asp Ala Leu Ile Leu Ile Gln Trp Asn Ile Arg Ala 
            820                 825                 830         


Phe Met Ala Val Lys Asn Trp Pro Trp Met Arg Leu Phe Phe Lys Ile 
        835                 840                 845             


Lys Pro Leu Val Lys Ser Ser Glu Val Gly Glu Glu Val Ala Gly Leu 
    850                 855                 860                 


Lys Glu Glu Cys Ala Gln Leu Gln Lys Ala Leu Glu Lys Ser Glu Phe 
865                 870                 875                 880 


Gln Arg Glu Glu Leu Lys Ala Lys Gln Val Ser Leu Thr Gln Glu Lys 
                885                 890                 895     


Asn Asp Leu Ile Leu Gln Leu Gln Ala Glu Gln Glu Thr Leu Ala Asn 
            900                 905                 910         


Val Glu Glu Gln Cys Glu Trp Leu Ile Lys Ser Lys Ile Gln Leu Glu 
        915                 920                 925             


Ala Arg Val Lys Glu Leu Ser Glu Arg Val Glu Glu Glu Glu Glu Ile 
    930                 935                 940                 


Asn Ser Glu Leu Thr Ala Arg Gly Arg Lys Leu Glu Asp Glu Cys Phe 
945                 950                 955                 960 


Glu Leu Lys Lys Glu Ile Asp Asp Leu Glu Thr Met Leu Val Lys Ser 
                965                 970                 975     


Glu Lys Glu Lys Arg Thr Thr Glu His Lys Val Lys Asn Leu Thr Glu 
            980                 985                 990         


Glu Val Glu Phe Leu Asn Glu Asp  Ile Ser Lys Leu Asn  Arg Ala Ala 
        995                 1000                 1005             


Lys Val  Val Gln Glu Ala His  Gln Gln Thr Leu Asp  Asp Leu His 
    1010                 1015                 1020             


Met Glu  Glu Glu Lys Leu Ser  Ser Leu Ser Lys Ala  Asn Leu Lys 
    1025                 1030                 1035             


Leu Glu  Gln Gln Val Asp Glu  Leu Glu Gly Ala Leu  Glu Gln Glu 
    1040                 1045                 1050             


Arg Lys  Ala Arg Met Asn Cys  Glu Arg Glu Leu His  Lys Leu Glu 
    1055                 1060                 1065             


Gly Asn  Leu Lys Leu Asn Arg  Glu Ser Met Glu Asn  Leu Glu Ser 
    1070                 1075                 1080             


Ser Gln  Arg His Leu Ala Glu  Glu Leu Arg Lys Lys  Glu Leu Glu 
    1085                 1090                 1095             


Leu Ser  Gln Met Asn Ser Lys  Val Glu Asn Glu Lys  Gly Leu Val 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Thr Val  Lys Glu Leu Gln Thr  Gln Ile Lys 
    1115                 1120                 1125             


Asp Leu  Lys Glu Lys Leu Glu  Ala Glu Arg Thr Thr  Arg Ala Lys 
    1130                 1135                 1140             


Met Glu  Arg Glu Arg Ala Asp  Leu Thr Gln Asp Leu  Ala Asp Leu 
    1145                 1150                 1155             


Asn Glu  Arg Leu Glu Glu Val  Gly Gly Ser Ser Leu  Ala Gln Leu 
    1160                 1165                 1170             


Glu Ile  Thr Lys Lys Gln Glu  Thr Lys Phe Gln Lys  Leu His Arg 
    1175                 1180                 1185             


Asp Met  Glu Glu Ala Thr Leu  His Phe Glu Thr Thr  Ser Ala Ser 
    1190                 1195                 1200             


Leu Lys  Lys Arg His Ala Asp  Ser Leu Ala Glu Leu  Glu Gly Gln 
    1205                 1210                 1215             


Val Glu  Asn Leu Gln Gln Val  Lys Gln Lys Leu Glu  Lys Asp Lys 
    1220                 1225                 1230             


Ser Asp  Leu Gln Leu Glu Val  Asp Asp Leu Leu Thr  Arg Val Glu 
    1235                 1240                 1245             


Gln Met  Thr Arg Ala Lys Ala  Asn Ala Glu Lys Leu  Cys Thr Leu 
    1250                 1255                 1260             


Tyr Glu  Glu Arg Leu His Glu  Ala Thr Ala Lys Leu  Asp Lys Val 
    1265                 1270                 1275             


Thr Gln  Leu Ala Asn Asp Leu  Ala Ala Gln Lys Thr  Lys Leu Trp 
    1280                 1285                 1290             


Ser Glu  Ser Gly Glu Phe Leu  Arg Arg Leu Glu Glu  Lys Glu Ala 
    1295                 1300                 1305             


Leu Ile  Asn Gln Leu Ser Arg  Glu Lys Ser Asn Phe  Thr Arg Gln 
    1310                 1315                 1320             


Ile Glu  Asp Leu Arg Gly Gln  Leu Glu Lys Glu Thr  Lys Ser Gln 
    1325                 1330                 1335             


Ser Ala  Leu Ala His Ala Leu  Gln Lys Ala Gln Arg  Asp Cys Asp 
    1340                 1345                 1350             


Leu Leu  Arg Glu Gln Tyr Glu  Glu Glu Gln Glu Val  Lys Ala Glu 
    1355                 1360                 1365             


Leu His  Arg Thr Leu Ser Lys  Val Asn Ala Glu Met  Val Gln Trp 
    1370                 1375                 1380             


Arg Met  Lys Tyr Glu Asn Asn  Val Ile Gln Arg Thr  Glu Asp Leu 
    1385                 1390                 1395             


Glu Asp  Ala Lys Lys Glu Leu  Ala Ile Arg Leu Gln  Glu Ala Ala 
    1400                 1405                 1410             


Glu Ala  Met Gly Val Ala Asn  Ala Arg Asn Ala Ser  Leu Glu Arg 
    1415                 1420                 1425             


Ala Arg  His Gln Leu Gln Leu  Glu Leu Gly Asp Ala  Leu Ser Asp 
    1430                 1435                 1440             


Leu Gly  Lys Val Arg Ser Ala  Ala Ala Arg Leu Asp  Gln Lys Gln 
    1445                 1450                 1455             


Leu Gln  Ser Gly Lys Ala Leu  Ala Asp Trp Lys Gln  Lys His Glu 
    1460                 1465                 1470             


Glu Ser  Gln Ala Leu Leu Asp  Ala Ser Gln Lys Glu  Val Gln Ala 
    1475                 1480                 1485             


Leu Ser  Thr Glu Leu Leu Lys  Leu Lys Asn Thr Tyr  Glu Glu Ser 
    1490                 1495                 1500             


Ile Val  Gly Gln Glu Thr Leu  Arg Arg Glu Asn Lys  Asn Leu Gln 
    1505                 1510                 1515             


Glu Glu  Ile Ser Asn Leu Thr  Asn Gln Val Arg Glu  Gly Thr Lys 
    1520                 1525                 1530             


Asn Leu  Thr Glu Met Glu Lys  Val Lys Lys Leu Ile  Glu Glu Glu 
    1535                 1540                 1545             


Lys Thr  Glu Val Gln Val Thr  Leu Glu Glu Thr Glu  Gly Ala Leu 
    1550                 1555                 1560             


Glu Arg  Asn Glu Ser Lys Ile  Leu His Phe Gln Leu  Glu Leu Leu 
    1565                 1570                 1575             


Glu Ala  Lys Ala Glu Leu Glu  Arg Lys Leu Ser Glu  Lys Asp Glu 
    1580                 1585                 1590             


Glu Ile  Glu Asn Phe Arg Arg  Lys Gln Gln Cys Thr  Ile Asp Ser 
    1595                 1600                 1605             


Leu Gln  Ser Ser Leu Asp Ser  Glu Ala Lys Ser Arg  Ile Glu Val 
    1610                 1615                 1620             


Thr Arg  Leu Lys Lys Lys Met  Glu Glu Asp Leu Asn  Glu Met Glu 
    1625                 1630                 1635             


Leu Gln  Leu Ser Cys Ala Asn  Arg Gln Val Ser Glu  Ala Thr Lys 
    1640                 1645                 1650             


Ser Leu  Gly Gln Leu Gln Ile  Gln Ile Lys Asp Leu  Gln Met Gln 
    1655                 1660                 1665             


Leu Asp  Asp Ser Thr Gln Leu  Asn Ser Asp Leu Lys  Glu Gln Val 
    1670                 1675                 1680             


Ala Val  Ala Glu Arg Arg Asn  Ser Leu Leu Gln Ser  Glu Leu Glu 
    1685                 1690                 1695             


Asp Leu  Arg Ser Leu Gln Glu  Gln Thr Glu Arg Gly  Arg Arg Leu 
    1700                 1705                 1710             


Ser Glu  Glu Glu Leu Leu Glu  Ala Thr Glu Arg Ile  Asn Leu Phe 
    1715                 1720                 1725             


Tyr Thr  Gln Asn Thr Ser Leu  Leu Ser Gln Lys Lys  Lys Leu Glu 
    1730                 1735                 1740             


Ala Asp  Val Ala Arg Met Gln  Lys Glu Ala Glu Glu  Val Val Gln 
    1745                 1750                 1755             


Glu Cys  Gln Asn Ala Glu Glu  Lys Ala Lys Lys Ala  Ala Ile Glu 
    1760                 1765                 1770             


Ala Ala  Asn Leu Ser Glu Glu  Leu Lys Lys Lys Gln  Asp Thr Ile 
    1775                 1780                 1785             


Ala His  Leu Glu Arg Thr Arg  Glu Asn Met Glu Gln  Thr Ile Thr 
    1790                 1795                 1800             


Asp Leu  Gln Lys Arg Leu Ala  Glu Ala Glu Gln Met  Ala Leu Met 
    1805                 1810                 1815             


Gly Ser  Arg Lys Gln Ile Gln  Lys Leu Glu Ser Arg  Val Arg Glu 
    1820                 1825                 1830             


Leu Glu  Gly Glu Leu Glu Gly  Glu Ile Arg Arg Ser  Ala Glu Ala 
    1835                 1840                 1845             


Gln Arg  Gly Ala Arg Arg Leu  Glu Arg Cys Ile Lys  Glu Leu Thr 
    1850                 1855                 1860             


Tyr Gln  Ala Glu Glu Asp Lys  Lys Asn Leu Ser Arg  Met Gln Thr 
    1865                 1870                 1875             


Gln Met  Asp Lys Leu Gln Leu  Lys Val Gln Asn Tyr  Lys Gln Gln 
    1880                 1885                 1890             


Val Glu  Val Ala Glu Thr Gln  Ala Asn Gln Tyr Leu  Ser Lys Tyr 
    1895                 1900                 1905             


Lys Lys  Gln Gln His Glu Leu  Asn Glu Val Lys Glu  Arg Ala Glu 
    1910                 1915                 1920             


Val Ala  Glu Ser Gln Val Asn  Lys Leu Lys Ile Lys  Ala Arg Glu 
    1925                 1930                 1935             


Phe Gly  Lys Lys Val Gln Glu  Glu 
    1940                 1945     


<210>  28
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Arg Thr Arg Thr Gly Ser Gln Leu Ala Ala Arg Glu Val Thr Gly 
1               5                   10                  15      


Ser Gly Ala Val Pro Arg Gln Leu Glu Gly Arg Arg Cys Gln Ala Gly 
            20                  25                  30          


Arg Asp Ala Asn Gly Gly Thr Ser Ser Asp Gly Ser Ser Ser Met Ala 
        35                  40                  45              


Ala Ile Tyr Gly Gly Val Glu Gly Gly Gly Thr Arg Ser Glu Val Leu 
    50                  55                  60                  


Leu Val Ser Glu Asp Gly Lys Ile Leu Ala Glu Ala Asp Gly Leu Ser 
65                  70                  75                  80  


Thr Asn His Trp Leu Ile Gly Thr Asp Lys Cys Val Glu Arg Ile Asn 
                85                  90                  95      


Glu Met Val Asn Arg Ala Lys Arg Lys Ala Gly Val Asp Pro Leu Val 
            100                 105                 110         


Pro Leu Arg Ser Leu Gly Leu Ser Leu Ser Gly Gly Asp Gln Glu Asp 
        115                 120                 125             


Ala Gly Arg Ile Leu Ile Glu Glu Leu Arg Asp Arg Phe Pro Tyr Leu 
    130                 135                 140                 


Ser Glu Ser Tyr Leu Ile Thr Thr Asp Ala Ala Gly Ser Ile Ala Thr 
145                 150                 155                 160 


Ala Thr Pro Asp Gly Gly Val Val Leu Ile Ser Gly Thr Gly Ser Asn 
                165                 170                 175     


Cys Arg Leu Ile Asn Pro Asp Gly Ser Glu Ser Gly Cys Gly Gly Trp 
            180                 185                 190         


Gly His Met Met Gly Asp Glu Gly Ser Ala Tyr Trp Ile Ala His Gln 
        195                 200                 205             


Ala Val Lys Ile Val Phe Asp Ser Ile Asp Asn Leu Glu Ala Ala Pro 
    210                 215                 220                 


His Asp Ile Gly Tyr Val Lys Gln Ala Met Phe His Tyr Phe Gln Val 
225                 230                 235                 240 


Pro Asp Arg Leu Gly Ile Leu Thr His Leu Tyr Arg Asp Phe Asp Lys 
                245                 250                 255     


Cys Arg Phe Ala Gly Phe Cys Arg Lys Ile Ala Glu Gly Ala Gln Gln 
            260                 265                 270         


Gly Asp Pro Leu Ser Arg Tyr Ile Phe Arg Lys Ala Gly Glu Met Leu 
        275                 280                 285             


Gly Arg His Ile Val Ala Val Leu Pro Glu Ile Asp Pro Val Leu Phe 
    290                 295                 300                 


Gln Gly Lys Ile Gly Leu Pro Ile Leu Cys Val Gly Ser Val Trp Lys 
305                 310                 315                 320 


Ser Trp Glu Leu Leu Lys Glu Gly Phe Leu Leu Ala Leu Thr Gln Gly 
                325                 330                 335     


Arg Glu Ile Gln Ala Gln Asn Phe Phe Ser Ser Phe Thr Leu Met Lys 
            340                 345                 350         


Leu Arg His Ser Ser Ala Leu Gly Gly Ala Ser Leu Gly Ala Arg His 
        355                 360                 365             


Ile Gly His Leu Leu Pro Met Asp Tyr Ser Ala Asn Ala Ile Ala Phe 
    370                 375                 380                 


Tyr Ser Tyr Thr Phe Ser 
385                 390 


<210>  29
<211>  6669
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ala Asp Asp Glu Asp Tyr Glu Glu Val Val Glu Tyr Tyr Thr Glu 
1               5                   10                  15      


Glu Val Val Tyr Glu Glu Val Pro Gly Glu Thr Ile Thr Lys Ile Tyr 
            20                  25                  30          


Glu Thr Thr Thr Thr Arg Thr Ser Asp Tyr Glu Gln Ser Glu Thr Ser 
        35                  40                  45              


Lys Pro Ala Leu Ala Gln Pro Ala Leu Ala Gln Pro Ala Ser Ala Lys 
    50                  55                  60                  


Pro Val Glu Arg Arg Lys Val Ile Arg Lys Lys Val Asp Pro Ser Lys 
65                  70                  75                  80  


Phe Met Thr Pro Tyr Ile Ala His Ser Gln Lys Met Gln Asp Leu Phe 
                85                  90                  95      


Ser Pro Asn Lys Tyr Lys Glu Lys Phe Glu Lys Thr Lys Gly Gln Pro 
            100                 105                 110         


Tyr Ala Ser Thr Thr Asp Thr Pro Glu Leu Arg Arg Ile Lys Lys Val 
        115                 120                 125             


Gln Asp Gln Leu Ser Glu Val Lys Tyr Arg Met Asp Gly Asp Val Ala 
    130                 135                 140                 


Lys Thr Ile Cys His Val Asp Glu Lys Ala Lys Asp Ile Glu His Ala 
145                 150                 155                 160 


Lys Lys Val Ser Gln Gln Val Ser Lys Val Leu Tyr Lys Gln Asn Trp 
                165                 170                 175     


Glu Asp Thr Lys Asp Lys Tyr Leu Leu Pro Pro Asp Ala Pro Glu Leu 
            180                 185                 190         


Val Gln Ala Val Lys Asn Thr Ala Met Phe Ser Lys Lys Leu Tyr Thr 
        195                 200                 205             


Glu Asp Trp Glu Ala Asp Lys Ser Leu Phe Tyr Pro Tyr Asn Asp Ser 
    210                 215                 220                 


Pro Glu Leu Arg Arg Val Ala Gln Ala Gln Lys Ala Leu Ser Asp Val 
225                 230                 235                 240 


Ala Tyr Lys Lys Gly Leu Ala Glu Gln Gln Ala Gln Phe Thr Pro Leu 
                245                 250                 255     


Ala Asp Pro Pro Asp Ile Glu Phe Ala Lys Lys Val Thr Asn Gln Val 
            260                 265                 270         


Ser Lys Gln Lys Tyr Lys Glu Asp Tyr Glu Asn Lys Ile Lys Gly Lys 
        275                 280                 285             


Trp Ser Glu Thr Pro Cys Phe Glu Val Ala Asn Ala Arg Met Asn Ala 
    290                 295                 300                 


Asp Asn Ile Ser Thr Arg Lys Tyr Gln Glu Asp Phe Glu Asn Met Lys 
305                 310                 315                 320 


Asp Gln Ile Tyr Phe Met Gln Thr Glu Thr Pro Glu Tyr Lys Met Asn 
                325                 330                 335     


Lys Lys Ala Gly Val Ala Ala Ser Lys Val Lys Tyr Lys Glu Asp Tyr 
            340                 345                 350         


Glu Lys Asn Lys Gly Lys Ala Asp Tyr Asn Val Leu Pro Ala Ser Glu 
        355                 360                 365             


Asn Pro Gln Leu Arg Gln Leu Lys Ala Ala Gly Asp Ala Leu Ser Asp 
    370                 375                 380                 


Lys Leu Tyr Lys Glu Asn Tyr Glu Lys Thr Lys Ala Lys Ser Ile Asn 
385                 390                 395                 400 


Tyr Cys Glu Thr Pro Lys Phe Lys Leu Asp Thr Val Leu Gln Asn Phe 
                405                 410                 415     


Ser Ser Asp Lys Lys Tyr Lys Asp Ser Tyr Leu Lys Asp Ile Leu Gly 
            420                 425                 430         


His Tyr Val Gly Ser Phe Glu Asp Pro Tyr His Ser His Cys Met Lys 
        435                 440                 445             


Val Thr Ala Gln Asn Ser Asp Lys Asn Tyr Lys Ala Glu Tyr Glu Glu 
    450                 455                 460                 


Asp Arg Gly Lys Gly Phe Phe Pro Gln Thr Ile Thr Gln Glu Tyr Glu 
465                 470                 475                 480 


Ala Ile Lys Lys Leu Asp Gln Cys Lys Asp His Thr Tyr Lys Val His 
                485                 490                 495     


Pro Asp Lys Thr Lys Phe Thr Gln Val Thr Asp Ser Pro Val Leu Leu 
            500                 505                 510         


Gln Ala Gln Val Asn Ser Lys Gln Leu Ser Asp Leu Asn Tyr Lys Ala 
        515                 520                 525             


Lys His Glu Ser Glu Lys Phe Lys Cys His Ile Pro Pro Asp Thr Pro 
    530                 535                 540                 


Ala Phe Ile Gln His Lys Val Asn Ala Tyr Asn Leu Ser Asp Asn Leu 
545                 550                 555                 560 


Tyr Lys Gln Asp Trp Glu Lys Ser Lys Ala Lys Lys Phe Asp Ile Lys 
                565                 570                 575     


Val Asp Ala Ile Pro Leu Leu Ala Ala Lys Ala Asn Thr Lys Asn Thr 
            580                 585                 590         


Ser Asp Val Met Tyr Lys Lys Asp Tyr Glu Lys Asn Lys Gly Lys Met 
        595                 600                 605             


Ile Gly Val Leu Ser Ile Asn Asp Asp Pro Lys Met Leu His Ser Leu 
    610                 615                 620                 


Lys Val Ala Lys Asn Gln Ser Asp Arg Leu Tyr Lys Glu Asn Tyr Glu 
625                 630                 635                 640 


Lys Thr Lys Ala Lys Ser Met Asn Tyr Cys Glu Thr Pro Lys Tyr Gln 
                645                 650                 655     


Leu Asp Thr Gln Leu Lys Asn Phe Ser Glu Ala Arg Tyr Lys Asp Leu 
            660                 665                 670         


Tyr Val Lys Asp Val Leu Gly His Tyr Val Gly Ser Met Glu Asp Pro 
        675                 680                 685             


Tyr His Thr His Cys Met Lys Val Ala Ala Gln Asn Ser Asp Lys Ser 
    690                 695                 700                 


Tyr Lys Ala Glu Tyr Glu Glu Asp Lys Gly Lys Cys Tyr Phe Pro Gln 
705                 710                 715                 720 


Thr Ile Thr Gln Glu Tyr Glu Ala Ile Lys Lys Leu Asp Gln Cys Lys 
                725                 730                 735     


Asp His Thr Tyr Lys Val His Pro Asp Lys Thr Lys Phe Thr Ala Val 
            740                 745                 750         


Thr Asp Ser Pro Val Leu Leu Gln Ala Gln Leu Asn Thr Lys Gln Leu 
        755                 760                 765             


Ser Asp Leu Asn Tyr Lys Ala Lys His Glu Gly Glu Lys Phe Lys Cys 
    770                 775                 780                 


His Ile Pro Ala Asp Ala Pro Gln Phe Ile Gln His Arg Val Asn Ala 
785                 790                 795                 800 


Tyr Asn Leu Ser Asp Asn Val Tyr Lys Gln Asp Trp Glu Lys Ser Lys 
                805                 810                 815     


Ala Lys Lys Phe Asp Ile Lys Val Asp Ala Ile Pro Leu Leu Ala Ala 
            820                 825                 830         


Lys Ala Asn Thr Lys Asn Thr Ser Asp Val Met Tyr Lys Lys Asp Tyr 
        835                 840                 845             


Glu Lys Ser Lys Gly Lys Met Ile Gly Ala Leu Ser Ile Asn Asp Asp 
    850                 855                 860                 


Pro Lys Met Leu His Ser Leu Lys Thr Ala Lys Asn Gln Ser Asp Arg 
865                 870                 875                 880 


Glu Tyr Arg Lys Asp Tyr Glu Lys Ser Lys Thr Ile Tyr Thr Ala Pro 
                885                 890                 895     


Leu Asp Met Leu Gln Val Thr Gln Ala Lys Lys Ser Gln Ala Ile Ala 
            900                 905                 910         


Ser Asp Val Asp Tyr Lys His Ile Leu His Ser Tyr Ser Tyr Pro Pro 
        915                 920                 925             


Asp Ser Ile Asn Val Asp Leu Ala Lys Lys Ala Tyr Ala Leu Gln Ser 
    930                 935                 940                 


Asp Val Glu Tyr Lys Ala Asp Tyr Asn Ser Trp Met Lys Gly Cys Gly 
945                 950                 955                 960 


Trp Val Pro Phe Gly Ser Leu Glu Met Glu Lys Ala Lys Arg Ala Ser 
                965                 970                 975     


Asp Ile Leu Asn Glu Lys Lys Tyr Arg Gln His Pro Asp Thr Leu Lys 
            980                 985                 990         


Phe Thr Ser Ile Glu Asp Ala Pro  Ile Thr Val Gln Ser  Lys Ile Asn 
        995                 1000                 1005             


Gln Ala  Gln Arg Ser Asp Ile  Ala Tyr Lys Ala Lys  Gly Glu Glu 
    1010                 1015                 1020             


Ile Ile  His Lys Tyr Asn Leu  Pro Pro Asp Leu Pro  Gln Phe Ile 
    1025                 1030                 1035             


Gln Ala  Lys Val Asn Ala Tyr  Asn Ile Ser Glu Asn  Met Tyr Lys 
    1040                 1045                 1050             


Ala Asp  Leu Lys Asp Leu Ser  Lys Lys Gly Tyr Asp  Leu Arg Thr 
    1055                 1060                 1065             


Asp Ala  Ile Pro Ile Arg Ala  Ala Lys Ala Ala Arg  Gln Ala Ala 
    1070                 1075                 1080             


Ser Asp  Val Gln Tyr Lys Lys  Asp Tyr Glu Lys Ala  Lys Gly Lys 
    1085                 1090                 1095             


Met Val  Gly Phe Gln Ser Leu  Gln Asp Asp Pro Lys  Leu Val His 
    1100                 1105                 1110             


Tyr Met  Asn Val Ala Lys Ile  Gln Ser Asp Arg Glu  Tyr Lys Lys 
    1115                 1120                 1125             


Asp Tyr  Glu Lys Thr Lys Ser  Lys Tyr Asn Thr Pro  His Asp Met 
    1130                 1135                 1140             


Phe Asn  Val Val Ala Ala Lys  Lys Ala Gln Asp Val  Val Ser Asn 
    1145                 1150                 1155             


Val Asn  Tyr Lys His Ser Leu  His His Tyr Thr Tyr  Leu Pro Asp 
    1160                 1165                 1170             


Ala Met  Asp Leu Glu Leu Ser  Lys Asn Met Met Gln  Ile Gln Ser 
    1175                 1180                 1185             


Asp Asn  Val Tyr Lys Glu Asp  Tyr Asn Asn Trp Met  Lys Gly Ile 
    1190                 1195                 1200             


Gly Trp  Ile Pro Ile Gly Ser  Leu Asp Val Glu Lys  Val Lys Lys 
    1205                 1210                 1215             


Ala Gly  Asp Ala Leu Asn Glu  Lys Lys Tyr Arg Gln  His Pro Asp 
    1220                 1225                 1230             


Thr Leu  Lys Phe Thr Ser Ile  Val Asp Ser Pro Val  Met Val Gln 
    1235                 1240                 1245             


Ala Lys  Gln Asn Thr Lys Gln  Val Ser Asp Ile Leu  Tyr Lys Ala 
    1250                 1255                 1260             


Lys Gly  Glu Asp Val Lys His  Lys Tyr Thr Met Ser  Pro Asp Leu 
    1265                 1270                 1275             


Pro Gln  Phe Leu Gln Ala Lys  Cys Asn Ala Tyr Asn  Ile Ser Asp 
    1280                 1285                 1290             


Val Cys  Tyr Lys Arg Asp Trp  Tyr Asp Leu Ile Ala  Lys Gly Asn 
    1295                 1300                 1305             


Asn Val  Leu Gly Asp Ala Ile  Pro Ile Thr Ala Ala  Lys Ala Ser 
    1310                 1315                 1320             


Arg Asn  Ile Ala Ser Asp Tyr  Lys Tyr Lys Glu Ala  Tyr Glu Lys 
    1325                 1330                 1335             


Ser Lys  Gly Lys His Val Gly  Phe Arg Ser Leu Gln  Asp Asp Pro 
    1340                 1345                 1350             


Lys Leu  Val His Tyr Met Asn  Val Ala Lys Leu Gln  Ser Asp Arg 
    1355                 1360                 1365             


Glu Tyr  Lys Lys Asn Tyr Glu  Asn Thr Lys Thr Ser  Tyr His Thr 
    1370                 1375                 1380             


Pro Gly  Asp Met Val Ser Ile  Thr Ala Ala Lys Met  Ala Gln Asp 
    1385                 1390                 1395             


Val Ala  Thr Asn Val Asn Tyr  Lys Gln Pro Leu His  His Tyr Thr 
    1400                 1405                 1410             


Tyr Leu  Pro Asp Ala Met Ser  Leu Glu His Thr Arg  Asn Val Asn 
    1415                 1420                 1425             


Gln Ile  Gln Ser Asp Asn Val  Tyr Lys Asp Glu Tyr  Asn Ser Phe 
    1430                 1435                 1440             


Leu Lys  Gly Ile Gly Trp Ile  Pro Ile Gly Ser Leu  Glu Val Glu 
    1445                 1450                 1455             


Lys Val  Lys Lys Ala Gly Asp  Ala Leu Asn Glu Arg  Lys Tyr Arg 
    1460                 1465                 1470             


Gln His  Pro Asp Thr Val Lys  Phe Thr Ser Val Pro  Asp Ser Met 
    1475                 1480                 1485             


Gly Met  Val Leu Ala Gln His  Asn Thr Lys Gln Leu  Ser Asp Leu 
    1490                 1495                 1500             


Asn Tyr  Lys Val Glu Gly Glu  Lys Leu Lys His Lys  Tyr Thr Ile 
    1505                 1510                 1515             


Asp Pro  Glu Leu Pro Gln Phe  Ile Gln Ala Lys Val  Asn Ala Leu 
    1520                 1525                 1530             


Asn Met  Ser Asp Ala His Tyr  Lys Ala Asp Trp Lys  Lys Thr Ile 
    1535                 1540                 1545             


Ala Lys  Gly Tyr Asp Leu Arg  Pro Asp Ala Ile Pro  Ile Val Ala 
    1550                 1555                 1560             


Ala Lys  Ser Ser Arg Asn Ile  Ala Ser Asp Cys Lys  Tyr Lys Glu 
    1565                 1570                 1575             


Ala Tyr  Glu Lys Ala Lys Gly  Lys Gln Val Gly Phe  Leu Ser Leu 
    1580                 1585                 1590             


Gln Asp  Asp Pro Lys Leu Val  His Tyr Met Asn Val  Ala Lys Ile 
    1595                 1600                 1605             


Gln Ser  Asp Arg Glu Tyr Lys  Lys Gly Tyr Glu Ala  Ser Lys Thr 
    1610                 1615                 1620             


Lys Tyr  His Thr Pro Leu Asp  Met Val Ser Val Thr  Ala Ala Lys 
    1625                 1630                 1635             


Lys Ser  Gln Glu Val Ala Thr  Asn Ala Asn Tyr Arg  Gln Ser Tyr 
    1640                 1645                 1650             


His His  Tyr Thr Leu Leu Pro  Asp Ala Leu Asn Val  Glu His Ser 
    1655                 1660                 1665             


Arg Asn  Ala Met Gln Ile Gln  Ser Asp Asn Leu Tyr  Lys Ser Asp 
    1670                 1675                 1680             


Phe Thr  Asn Trp Met Lys Gly  Ile Gly Trp Val Pro  Ile Glu Ser 
    1685                 1690                 1695             


Leu Glu  Val Glu Lys Ala Lys  Lys Ala Gly Glu Ile  Leu Ser Glu 
    1700                 1705                 1710             


Lys Lys  Tyr Arg Gln His Pro  Glu Lys Leu Lys Phe  Thr Tyr Ala 
    1715                 1720                 1725             


Met Asp  Thr Met Glu Gln Ala  Leu Asn Lys Ser Asn  Lys Leu Asn 
    1730                 1735                 1740             


Met Asp  Lys Arg Leu Tyr Thr  Glu Lys Trp Asn Lys  Asp Lys Thr 
    1745                 1750                 1755             


Thr Ile  His Val Met Pro Asp  Thr Pro Asp Ile Leu  Leu Ser Arg 
    1760                 1765                 1770             


Val Asn  Gln Ile Thr Met Ser  Asp Lys Leu Tyr Lys  Ala Gly Trp 
    1775                 1780                 1785             


Glu Glu  Glu Lys Lys Lys Gly  Tyr Asp Leu Arg Pro  Asp Ala Ile 
    1790                 1795                 1800             


Ala Ile  Lys Ala Ala Arg Ala  Ser Arg Asp Ile Ala  Ser Asp Tyr 
    1805                 1810                 1815             


Lys Tyr  Lys Lys Ala Tyr Glu  Gln Ala Lys Gly Lys  His Ile Gly 
    1820                 1825                 1830             


Phe Arg  Ser Leu Glu Asp Asp  Pro Lys Leu Val His  Phe Met Gln 
    1835                 1840                 1845             


Val Ala  Lys Met Gln Ser Asp  Arg Glu Tyr Lys Lys  Gly Tyr Glu 
    1850                 1855                 1860             


Lys Ser  Lys Thr Ser Phe His  Thr Pro Val Asp Met  Leu Ser Val 
    1865                 1870                 1875             


Val Ala  Ala Lys Lys Ser Gln  Glu Val Ala Thr Asn  Ala Asn Tyr 
    1880                 1885                 1890             


Arg Asn  Val Ile His Thr Tyr  Asn Met Leu Pro Asp  Ala Met Ser 
    1895                 1900                 1905             


Phe Glu  Leu Ala Lys Asn Met  Met Gln Ile Gln Ser  Asp Asn Gln 
    1910                 1915                 1920             


Tyr Lys  Ala Asp Tyr Ala Asp  Phe Met Lys Gly Ile  Gly Trp Leu 
    1925                 1930                 1935             


Pro Leu  Gly Ser Leu Glu Ala  Glu Lys Asn Lys Lys  Ala Met Glu 
    1940                 1945                 1950             


Ile Ile  Ser Glu Lys Lys Tyr  Arg Gln His Pro Asp  Thr Leu Lys 
    1955                 1960                 1965             


Tyr Ser  Thr Leu Met Asp Ser  Met Asn Met Val Leu  Ala Gln Asn 
    1970                 1975                 1980             


Asn Ala  Lys Ile Met Asn Glu  His Leu Tyr Lys Gln  Ala Trp Glu 
    1985                 1990                 1995             


Ala Asp  Lys Thr Lys Val His  Ile Met Pro Asp Ile  Pro Gln Ile 
    2000                 2005                 2010             


Ile Leu  Ala Lys Ala Asn Ala  Ile Asn Met Ser Asp  Lys Leu Tyr 
    2015                 2020                 2025             


Lys Leu  Ser Leu Glu Glu Ser  Lys Lys Lys Gly Tyr  Asp Leu Arg 
    2030                 2035                 2040             


Pro Asp  Ala Ile Pro Ile Lys  Ala Ala Lys Ala Ser  Arg Asp Ile 
    2045                 2050                 2055             


Ala Ser  Asp Tyr Lys Tyr Lys  Tyr Asn Tyr Glu Lys  Gly Lys Gly 
    2060                 2065                 2070             


Lys Met  Val Gly Phe Arg Ser  Leu Glu Asp Asp Pro  Lys Leu Val 
    2075                 2080                 2085             


His Ser  Met Gln Val Ala Lys  Met Gln Ser Asp Arg  Glu Tyr Lys 
    2090                 2095                 2100             


Lys Asn  Tyr Glu Asn Thr Lys  Thr Ser Tyr His Thr  Pro Ala Asp 
    2105                 2110                 2115             


Met Leu  Ser Val Thr Ala Ala  Lys Asp Ala Gln Ala  Asn Ile Thr 
    2120                 2125                 2130             


Asn Thr  Asn Tyr Lys His Leu  Ile His Lys Tyr Ile  Leu Leu Pro 
    2135                 2140                 2145             


Asp Ala  Met Asn Ile Glu Leu  Thr Arg Asn Met Asn  Arg Ile Gln 
    2150                 2155                 2160             


Ser Asp  Asn Glu Tyr Lys Gln  Asp Tyr Asn Glu Trp  Tyr Lys Gly 
    2165                 2170                 2175             


Leu Gly  Trp Ser Pro Ala Gly  Ser Leu Glu Val Glu  Lys Ala Lys 
    2180                 2185                 2190             


Lys Ala  Thr Glu Tyr Ala Ser  Asp Gln Lys Tyr Arg  Gln His Pro 
    2195                 2200                 2205             


Ser Asn  Phe Gln Phe Lys Lys  Leu Thr Asp Ser Met  Asp Met Val 
    2210                 2215                 2220             


Leu Ala  Lys Gln Asn Ala His  Thr Met Asn Lys His  Leu Tyr Thr 
    2225                 2230                 2235             


Ile Asp  Trp Asn Lys Asp Lys  Thr Lys Ile His Val  Met Pro Asp 
    2240                 2245                 2250             


Thr Pro  Asp Ile Leu Gln Ala  Lys Gln Asn Gln Thr  Leu Tyr Ser 
    2255                 2260                 2265             


Gln Lys  Leu Tyr Lys Leu Gly  Trp Glu Glu Ala Leu  Lys Lys Gly 
    2270                 2275                 2280             


Tyr Asp  Leu Pro Val Asp Ala  Ile Ser Val Gln Leu  Ala Lys Ala 
    2285                 2290                 2295             


Ser Arg  Asp Ile Ala Ser Asp  Tyr Lys Tyr Lys Gln  Gly Tyr Arg 
    2300                 2305                 2310             


Lys Gln  Leu Gly His His Val  Gly Phe Arg Ser Leu  Gln Asp Asp 
    2315                 2320                 2325             


Pro Lys  Leu Val Leu Ser Met  Asn Val Ala Lys Met  Gln Ser Glu 
    2330                 2335                 2340             


Arg Glu  Tyr Lys Lys Asp Phe  Glu Lys Trp Lys Thr  Lys Phe Ser 
    2345                 2350                 2355             


Ser Pro  Val Asp Met Leu Gly  Val Val Leu Ala Lys  Lys Cys Gln 
    2360                 2365                 2370             


Glu Leu  Val Ser Asp Val Asp  Tyr Lys Asn Tyr Leu  His Gln Trp 
    2375                 2380                 2385             


Thr Cys  Leu Pro Asp Gln Asn  Asp Val Val Gln Ala  Lys Lys Val 
    2390                 2395                 2400             


Tyr Glu  Leu Gln Ser Glu Asn  Leu Tyr Lys Ser Asp  Leu Glu Trp 
    2405                 2410                 2415             


Leu Arg  Gly Ile Gly Trp Ser  Pro Leu Gly Ser Leu  Glu Ala Glu 
    2420                 2425                 2430             


Lys Asn  Lys Arg Ala Ser Glu  Ile Ile Ser Glu Lys  Lys Tyr Arg 
    2435                 2440                 2445             


Gln Pro  Pro Asp Arg Asn Lys  Phe Thr Ser Ile Pro  Asp Ala Met 
    2450                 2455                 2460             


Asp Ile  Val Leu Ala Lys Thr  Asn Ala Lys Asn Arg  Ser Asp Arg 
    2465                 2470                 2475             


Leu Tyr  Arg Glu Ala Trp Asp  Lys Asp Lys Thr Gln  Ile His Ile 
    2480                 2485                 2490             


Met Pro  Asp Thr Pro Asp Ile  Val Leu Ala Lys Ala  Asn Leu Ile 
    2495                 2500                 2505             


Asn Thr  Ser Asp Lys Leu Tyr  Arg Met Gly Tyr Glu  Glu Leu Lys 
    2510                 2515                 2520             


Arg Lys  Gly Tyr Asp Leu Pro  Val Asp Ala Ile Pro  Ile Lys Ala 
    2525                 2530                 2535             


Ala Lys  Ala Ser Arg Glu Ile  Ala Ser Glu Tyr Lys  Tyr Lys Glu 
    2540                 2545                 2550             


Gly Phe  Arg Lys Gln Leu Gly  His His Ile Gly Ala  Arg Asn Ile 
    2555                 2560                 2565             


Glu Asp  Asp Pro Lys Met Met  Trp Ser Met His Val  Ala Lys Ile 
    2570                 2575                 2580             


Gln Ser  Asp Arg Glu Tyr Lys  Lys Asp Phe Glu Lys  Trp Lys Thr 
    2585                 2590                 2595             


Lys Phe  Ser Ser Pro Val Asp  Met Leu Gly Val Val  Leu Ala Lys 
    2600                 2605                 2610             


Lys Cys  Gln Thr Leu Val Ser  Asp Val Asp Tyr Lys  Asn Tyr Leu 
    2615                 2620                 2625             


His Gln  Trp Thr Cys Leu Pro  Asp Gln Ser Asp Val  Ile His Ala 
    2630                 2635                 2640             


Arg Gln  Ala Tyr Asp Leu Gln  Ser Asp Asn Leu Tyr  Lys Ser Asp 
    2645                 2650                 2655             


Leu Gln  Trp Leu Lys Gly Ile  Gly Trp Met Thr Ser  Gly Ser Leu 
    2660                 2665                 2670             


Glu Asp  Glu Lys Asn Lys Arg  Ala Thr Gln Ile Leu  Ser Asp His 
    2675                 2680                 2685             


Val Tyr  Arg Gln His Pro Asp  Gln Phe Lys Phe Ser  Ser Leu Met 
    2690                 2695                 2700             


Asp Ser  Ile Pro Met Val Leu  Ala Lys Asn Asn Ala  Ile Thr Met 
    2705                 2710                 2715             


Asn His  Arg Leu Tyr Thr Glu  Ala Trp Asp Lys Asp  Lys Thr Thr 
    2720                 2725                 2730             


Val His  Ile Met Pro Asp Thr  Pro Glu Val Leu Leu  Ala Lys Gln 
    2735                 2740                 2745             


Asn Lys  Val Asn Tyr Ser Glu  Lys Leu Tyr Lys Leu  Gly Leu Glu 
    2750                 2755                 2760             


Glu Ala  Lys Arg Lys Gly Tyr  Asp Met Arg Val Asp  Ala Ile Pro 
    2765                 2770                 2775             


Ile Lys  Ala Ala Lys Ala Ser  Arg Asp Ile Ala Ser  Glu Phe Lys 
    2780                 2785                 2790             


Tyr Lys  Glu Gly Tyr Arg Lys  Gln Leu Gly His His  Ile Gly Ala 
    2795                 2800                 2805             


Arg Ala  Ile Arg Asp Asp Pro  Lys Met Met Trp Ser  Met His Val 
    2810                 2815                 2820             


Ala Lys  Ile Gln Ser Asp Arg  Glu Tyr Lys Lys Asp  Phe Glu Lys 
    2825                 2830                 2835             


Trp Lys  Thr Lys Phe Ser Ser  Pro Val Asp Met Leu  Gly Val Val 
    2840                 2845                 2850             


Leu Ala  Lys Lys Cys Gln Thr  Leu Val Ser Asp Val  Asp Tyr Lys 
    2855                 2860                 2865             


Asn Tyr  Leu His Gln Trp Thr  Cys Leu Pro Asp Gln  Ser Asp Val 
    2870                 2875                 2880             


Ile His  Ala Arg Gln Ala Tyr  Asp Leu Gln Ser Asp  Asn Met Tyr 
    2885                 2890                 2895             


Lys Ser  Asp Leu Gln Trp Met  Arg Gly Ile Gly Trp  Val Ser Ile 
    2900                 2905                 2910             


Gly Ser  Leu Asp Val Glu Lys  Cys Lys Arg Ala Thr  Glu Ile Leu 
    2915                 2920                 2925             


Ser Asp  Lys Ile Tyr Arg Gln  Pro Pro Asp Arg Phe  Lys Phe Thr 
    2930                 2935                 2940             


Ser Val  Thr Asp Ser Leu Glu  Gln Val Leu Ala Lys  Asn Asn Ala 
    2945                 2950                 2955             


Leu Asn  Met Asn Lys Arg Leu  Tyr Thr Glu Ala Trp  Asp Lys Asp 
    2960                 2965                 2970             


Lys Thr  Gln Ile His Ile Met  Pro Asp Thr Pro Glu  Ile Met Leu 
    2975                 2980                 2985             


Ala Arg  Gln Asn Lys Ile Asn  Tyr Ser Glu Thr Leu  Tyr Lys Leu 
    2990                 2995                 3000             


Ala Asn  Glu Glu Ala Lys Lys  Lys Gly Tyr Asp Leu  Arg Ser Asp 
    3005                 3010                 3015             


Ala Ile  Pro Ile Val Ala Ala  Lys Ala Ser Arg Asp  Val Ile Ser 
    3020                 3025                 3030             


Asp Tyr  Lys Tyr Lys Asp Gly  Tyr Arg Lys Gln Leu  Gly His His 
    3035                 3040                 3045             


Ile Gly  Ala Arg Asn Ile Glu  Asp Asp Pro Lys Met  Met Trp Ser 
    3050                 3055                 3060             


Met His  Val Ala Lys Ile Gln  Ser Asp Arg Glu Tyr  Lys Lys Asp 
    3065                 3070                 3075             


Phe Glu  Lys Trp Lys Thr Lys  Phe Ser Ser Pro Val  Asp Met Leu 
    3080                 3085                 3090             


Gly Val  Val Leu Ala Lys Lys  Cys Gln Thr Leu Val  Ser Asp Val 
    3095                 3100                 3105             


Asp Tyr  Lys Asn Tyr Leu His  Glu Trp Thr Cys Leu  Pro Asp Gln 
    3110                 3115                 3120             


Asn Asp  Val Ile His Ala Arg  Gln Ala Tyr Asp Leu  Gln Ser Asp 
    3125                 3130                 3135             


Asn Ile  Tyr Lys Ser Asp Leu  Gln Trp Leu Arg Gly  Ile Gly Trp 
    3140                 3145                 3150             


Val Pro  Ile Gly Ser Met Asp  Val Val Lys Cys Lys  Arg Ala Ala 
    3155                 3160                 3165             


Glu Ile  Leu Ser Asp Asn Ile  Tyr Arg Gln Pro Pro  Asp Lys Leu 
    3170                 3175                 3180             


Lys Phe  Thr Ser Val Thr Asp  Ser Leu Glu Gln Val  Leu Ala Lys 
    3185                 3190                 3195             


Asn Asn  Ala Leu Asn Met Asn  Lys Arg Leu Tyr Thr  Glu Ala Trp 
    3200                 3205                 3210             


Asp Lys  Asp Lys Thr Gln Val  His Ile Met Pro Asp  Thr Pro Glu 
    3215                 3220                 3225             


Ile Met  Leu Ala Arg Gln Asn  Lys Ile Asn Tyr Ser  Glu Ser Leu 
    3230                 3235                 3240             


Tyr Arg  Gln Ala Met Glu Glu  Ala Lys Lys Glu Gly  Tyr Asp Leu 
    3245                 3250                 3255             


Arg Ser  Asp Ala Ile Pro Ile  Val Ala Ala Lys Ala  Ser Arg Asp 
    3260                 3265                 3270             


Ile Ala  Ser Asp Tyr Lys Tyr  Lys Glu Ala Tyr Arg  Lys Gln Leu 
    3275                 3280                 3285             


Gly His  His Ile Gly Ala Arg  Ala Val His Asp Asp  Pro Lys Ile 
    3290                 3295                 3300             


Met Trp  Ser Leu His Ile Ala  Lys Val Gln Ser Asp  Arg Glu Tyr 
    3305                 3310                 3315             


Lys Lys  Asp Phe Glu Lys Tyr  Lys Thr Arg Tyr Ser  Ser Pro Val 
    3320                 3325                 3330             


Asp Met  Leu Gly Ile Val Leu  Ala Lys Lys Cys Gln  Thr Leu Val 
    3335                 3340                 3345             


Ser Asp  Val Asp Tyr Lys His  Pro Leu His Glu Trp  Ile Cys Leu 
    3350                 3355                 3360             


Pro Asp  Gln Asn Asp Ile Ile  His Ala Arg Lys Ala  Tyr Asp Leu 
    3365                 3370                 3375             


Gln Ser  Asp Asn Leu Tyr Lys  Ser Asp Leu Glu Trp  Met Lys Gly 
    3380                 3385                 3390             


Ile Gly  Trp Val Pro Ile Asp  Ser Leu Glu Val Val  Arg Ala Lys 
    3395                 3400                 3405             


Arg Ala  Gly Glu Leu Leu Ser  Asp Thr Ile Tyr Arg  Gln Arg Pro 
    3410                 3415                 3420             


Glu Thr  Leu Lys Phe Thr Ser  Ile Thr Asp Thr Pro  Glu Gln Val 
    3425                 3430                 3435             


Leu Ala  Lys Asn Asn Ala Leu  Asn Met Asn Lys Arg  Leu Tyr Thr 
    3440                 3445                 3450             


Glu Ala  Trp Asp Asn Asp Lys  Lys Thr Ile His Val  Met Pro Asp 
    3455                 3460                 3465             


Thr Pro  Glu Ile Met Leu Ala  Lys Leu Asn Arg Ile  Asn Tyr Ser 
    3470                 3475                 3480             


Asp Lys  Leu Tyr Lys Leu Ala  Leu Glu Glu Ser Lys  Lys Glu Gly 
    3485                 3490                 3495             


Tyr Asp  Leu Arg Leu Asp Ala  Ile Pro Ile Gln Ala  Ala Lys Ala 
    3500                 3505                 3510             


Ser Arg  Asp Ile Ala Ser Asp  Tyr Lys Tyr Lys Glu  Gly Tyr Arg 
    3515                 3520                 3525             


Lys Gln  Leu Gly His His Ile  Gly Ala Arg Asn Ile  Lys Asp Asp 
    3530                 3535                 3540             


Pro Lys  Met Met Trp Ser Ile  His Val Ala Lys Ile  Gln Ser Asp 
    3545                 3550                 3555             


Arg Glu  Tyr Lys Lys Glu Phe  Glu Lys Trp Lys Thr  Lys Phe Ser 
    3560                 3565                 3570             


Ser Pro  Val Asp Met Leu Gly  Val Val Leu Ala Lys  Lys Cys Gln 
    3575                 3580                 3585             


Ile Leu  Val Ser Asp Ile Asp  Tyr Lys His Pro Leu  His Glu Trp 
    3590                 3595                 3600             


Thr Cys  Leu Pro Asp Gln Asn  Asp Val Ile Gln Ala  Arg Lys Ala 
    3605                 3610                 3615             


Tyr Asp  Leu Gln Ser Asp Ala  Ile Tyr Lys Ser Asp  Leu Glu Trp 
    3620                 3625                 3630             


Leu Arg  Gly Ile Gly Trp Val  Pro Ile Gly Ser Val  Glu Val Glu 
    3635                 3640                 3645             


Lys Val  Lys Arg Ala Gly Glu  Ile Leu Ser Asp Arg  Lys Tyr Arg 
    3650                 3655                 3660             


Gln Pro  Ala Asp Gln Leu Lys  Phe Thr Cys Ile Thr  Asp Thr Pro 
    3665                 3670                 3675             


Glu Ile  Val Leu Ala Lys Asn  Asn Ala Leu Thr Met  Ser Lys His 
    3680                 3685                 3690             


Leu Tyr  Thr Glu Ala Trp Asp  Ala Asp Lys Thr Ser  Ile His Val 
    3695                 3700                 3705             


Met Pro  Asp Thr Pro Asp Ile  Leu Leu Ala Lys Ser  Asn Ser Ala 
    3710                 3715                 3720             


Asn Ile  Ser Gln Lys Leu Tyr  Thr Lys Gly Trp Asp  Glu Ser Lys 
    3725                 3730                 3735             


Met Lys  Asp Tyr Asp Leu Arg  Ala Asp Ala Ile Ser  Ile Lys Ser 
    3740                 3745                 3750             


Ala Lys  Ala Ser Arg Asp Ile  Ala Ser Asp Tyr Lys  Tyr Lys Glu 
    3755                 3760                 3765             


Ala Tyr  Glu Lys Gln Lys Gly  His His Ile Gly Ala  Gln Ser Ile 
    3770                 3775                 3780             


Glu Asp  Asp Pro Lys Ile Met  Cys Ala Ile His Ala  Gly Lys Ile 
    3785                 3790                 3795             


Gln Ser  Glu Arg Glu Tyr Lys  Lys Glu Phe Gln Lys  Trp Lys Thr 
    3800                 3805                 3810             


Lys Phe  Ser Ser Pro Val Asp  Met Leu Ser Ile Leu  Leu Ala Lys 
    3815                 3820                 3825             


Lys Cys  Gln Thr Leu Val Thr  Asp Ile Asp Tyr Arg  Asn Tyr Leu 
    3830                 3835                 3840             


His Glu  Trp Thr Cys Met Pro  Asp Gln Asn Asp Ile  Ile Gln Ala 
    3845                 3850                 3855             


Lys Lys  Ala Tyr Asp Leu Gln  Ser Asp Ala Leu Tyr  Lys Ala Asp 
    3860                 3865                 3870             


Leu Glu  Trp Leu Arg Gly Ile  Gly Trp Met Pro Gln  Gly Ser Pro 
    3875                 3880                 3885             


Glu Val  Leu Arg Val Lys Asn  Ala Gln Asn Ile Phe  Cys Asp Ser 
    3890                 3895                 3900             


Val Tyr  Arg Thr Pro Val Val  Asn Leu Lys Tyr Thr  Ser Ile Val 
    3905                 3910                 3915             


Asp Thr  Pro Glu Val Val Leu  Ala Lys Ser Asn Ala  Glu Asn Ile 
    3920                 3925                 3930             


Ser Ile  Pro Lys Tyr Arg Glu  Val Trp Asp Lys Asp  Lys Thr Ser 
    3935                 3940                 3945             


Ile His  Ile Met Pro Asp Thr  Pro Glu Ile Asn Leu  Ala Arg Ala 
    3950                 3955                 3960             


Asn Ala  Leu Asn Val Ser Asn  Lys Leu Tyr Arg Glu  Gly Trp Asp 
    3965                 3970                 3975             


Glu Met  Lys Ala Gly Cys Asp  Val Arg Leu Asp Ala  Ile Pro Ile 
    3980                 3985                 3990             


Gln Ala  Ala Lys Ala Ser Arg  Glu Ile Ala Ser Asp  Tyr Lys Tyr 
    3995                 4000                 4005             


Lys Leu  Asp His Glu Lys Gln  Lys Gly His Tyr Val  Gly Thr Leu 
    4010                 4015                 4020             


Thr Ala  Arg Asp Asp Asn Lys  Ile Arg Trp Ala Leu  Ile Ala Asp 
    4025                 4030                 4035             


Lys Leu  Gln Asn Glu Arg Glu  Tyr Arg Leu Asp Trp  Ala Lys Trp 
    4040                 4045                 4050             


Lys Ala  Lys Ile Gln Ser Pro  Val Asp Met Leu Ser  Ile Leu His 
    4055                 4060                 4065             


Ser Lys  Asn Ser Gln Ala Leu  Val Ser Asp Met Asp  Tyr Arg Asn 
    4070                 4075                 4080             


Tyr Leu  His Gln Trp Thr Cys  Met Pro Asp Gln Asn  Asp Val Ile 
    4085                 4090                 4095             


Gln Ala  Lys Lys Ala Tyr Glu  Leu Gln Ser Asp Asn  Val Tyr Lys 
    4100                 4105                 4110             


Ala Asp  Leu Glu Trp Leu Arg  Gly Ile Gly Trp Met  Pro Asn Asp 
    4115                 4120                 4125             


Ser Val  Ser Val Asn His Ala  Lys His Ala Ala Asp  Ile Phe Ser 
    4130                 4135                 4140             


Glu Lys  Lys Tyr Arg Thr Lys  Ile Glu Thr Leu Asn  Phe Thr Pro 
    4145                 4150                 4155             


Val Asp  Asp Arg Val Asp Tyr  Val Thr Ala Lys Gln  Ser Gly Glu 
    4160                 4165                 4170             


Ile Leu  Asp Asp Ile Lys Tyr  Arg Lys Asp Trp Asn  Ala Thr Lys 
    4175                 4180                 4185             


Ser Lys  Tyr Thr Leu Thr Glu  Thr Pro Leu Leu His  Thr Ala Gln 
    4190                 4195                 4200             


Glu Ala  Ala Arg Ile Leu Asp  Gln Tyr Leu Tyr Lys  Glu Gly Trp 
    4205                 4210                 4215             


Glu Arg  Gln Lys Ala Thr Gly  Tyr Ile Leu Pro Pro  Asp Ala Val 
    4220                 4225                 4230             


Pro Phe  Val His Ala His His  Cys Asn Asp Val Gln  Ser Glu Leu 
    4235                 4240                 4245             


Lys Tyr  Lys Ala Glu His Val  Lys Gln Lys Gly His  Tyr Val Gly 
    4250                 4255                 4260             


Val Pro  Thr Met Arg Asp Asp  Pro Lys Leu Val Trp  Phe Glu His 
    4265                 4270                 4275             


Ala Gly  Gln Ile Gln Asn Glu  Arg Leu Tyr Lys Glu  Asp Tyr His 
    4280                 4285                 4290             


Lys Thr  Lys Ala Lys Ile Asn  Ile Pro Ala Asp Met  Val Ser Val 
    4295                 4300                 4305             


Leu Ala  Ala Lys Gln Gly Gln  Thr Leu Val Ser Asp  Ile Asp Tyr 
    4310                 4315                 4320             


Arg Asn  Tyr Leu His Gln Trp  Met Cys His Pro Asp  Gln Asn Asp 
    4325                 4330                 4335             


Val Ile  Gln Ala Arg Lys Ala  Tyr Asp Leu Gln Ser  Asp Asn Val 
    4340                 4345                 4350             


Tyr Arg  Ala Asp Leu Glu Trp  Leu Arg Gly Ile Gly  Trp Ile Pro 
    4355                 4360                 4365             


Leu Asp  Ser Val Asp His Val  Arg Val Thr Lys Asn  Gln Glu Met 
    4370                 4375                 4380             


Met Ser  Gln Ile Lys Tyr Lys  Lys Asn Ala Leu Glu  Asn Tyr Pro 
    4385                 4390                 4395             


Asn Phe  Arg Ser Val Val Asp  Pro Pro Glu Ile Val  Leu Ala Lys 
    4400                 4405                 4410             


Ile Asn  Ser Val Asn Gln Ser  Asp Val Lys Tyr Lys  Glu Thr Phe 
    4415                 4420                 4425             


Asn Lys  Ala Lys Gly Lys Tyr  Thr Phe Ser Pro Asp  Thr Pro His 
    4430                 4435                 4440             


Ile Ser  His Ser Lys Asp Met  Gly Lys Leu Tyr Ser  Thr Ile Leu 
    4445                 4450                 4455             


Tyr Lys  Gly Ala Trp Glu Gly  Thr Lys Ala Tyr Gly  Tyr Thr Leu 
    4460                 4465                 4470             


Asp Glu  Arg Tyr Ile Pro Ile  Val Gly Ala Lys His  Ala Asp Leu 
    4475                 4480                 4485             


Val Asn  Ser Glu Leu Lys Tyr  Lys Glu Thr Tyr Glu  Lys Gln Lys 
    4490                 4495                 4500             


Gly His  Tyr Leu Ala Gly Lys  Val Ile Gly Glu Phe  Pro Gly Val 
    4505                 4510                 4515             


Val His  Cys Leu Asp Phe Gln  Lys Met Arg Ser Ala  Leu Asn Tyr 
    4520                 4525                 4530             


Arg Lys  His Tyr Glu Asp Thr  Lys Ala Asn Val His  Ile Pro Asn 
    4535                 4540                 4545             


Asp Met  Met Asn His Val Leu  Ala Lys Arg Cys Gln  Tyr Ile Leu 
    4550                 4555                 4560             


Ser Asp  Leu Glu Tyr Arg His  Tyr Phe His Gln Trp  Thr Ser Leu 
    4565                 4570                 4575             


Leu Glu  Glu Pro Asn Val Ile  Arg Val Arg Asn Ala  Gln Glu Ile 
    4580                 4585                 4590             


Leu Ser  Asp Asn Val Tyr Lys  Asp Asp Leu Asn Trp  Leu Lys Gly 
    4595                 4600                 4605             


Ile Gly  Cys Tyr Val Trp Asp  Thr Pro Gln Ile Leu  His Ala Lys 
    4610                 4615                 4620             


Lys Ser  Tyr Asp Leu Gln Ser  Gln Leu Gln Tyr Thr  Ala Ala Gly 
    4625                 4630                 4635             


Lys Glu  Asn Leu Gln Asn Tyr  Asn Leu Val Thr Asp  Thr Pro Leu 
    4640                 4645                 4650             


Tyr Val  Thr Ala Val Gln Ser  Gly Ile Asn Ala Ser  Glu Val Lys 
    4655                 4660                 4665             


Tyr Lys  Glu Asn Tyr His Gln  Ile Lys Asp Lys Tyr  Thr Thr Val 
    4670                 4675                 4680             


Leu Glu  Thr Val Asp Tyr Asp  Arg Thr Arg Asn Leu  Lys Asn Leu 
    4685                 4690                 4695             


Tyr Ser  Ser Asn Leu Tyr Lys  Glu Ala Trp Asp Arg  Val Lys Ala 
    4700                 4705                 4710             


Thr Ser  Tyr Ile Leu Pro Ser  Ser Thr Leu Ser Leu  Thr His Ala 
    4715                 4720                 4725             


Lys Asn  Gln Lys His Leu Ala  Ser His Ile Lys Tyr  Arg Glu Glu 
    4730                 4735                 4740             


Tyr Glu  Lys Phe Lys Ala Leu  Tyr Thr Leu Pro Arg  Ser Val Asp 
    4745                 4750                 4755             


Asp Asp  Pro Asn Thr Ala Arg  Cys Leu Arg Val Gly  Lys Leu Asn 
    4760                 4765                 4770             


Ile Asp  Arg Leu Tyr Arg Ser  Val Tyr Glu Lys Asn  Lys Met Lys 
    4775                 4780                 4785             


Ile His  Ile Val Pro Asp Met  Val Glu Met Val Thr  Ala Lys Asp 
    4790                 4795                 4800             


Ser Gln  Lys Lys Val Ser Glu  Ile Asp Tyr Arg Leu  Arg Leu His 
    4805                 4810                 4815             


Glu Trp  Ile Cys His Pro Asp  Leu Gln Val Asn Asp  His Val Arg 
    4820                 4825                 4830             


Lys Val  Thr Asp Gln Ile Ser  Asp Ile Val Tyr Lys  Asp Asp Leu 
    4835                 4840                 4845             


Asn Trp  Leu Lys Gly Ile Gly  Cys Tyr Val Trp Asp  Thr Pro Glu 
    4850                 4855                 4860             


Ile Leu  His Ala Lys His Ala  Tyr Asp Leu Arg Asp  Asp Ile Lys 
    4865                 4870                 4875             


Tyr Lys  Ala His Met Leu Lys  Thr Arg Asn Asp Tyr  Lys Leu Val 
    4880                 4885                 4890             


Thr Asp  Thr Pro Val Tyr Val  Gln Ala Val Lys Ser  Gly Lys Gln 
    4895                 4900                 4905             


Leu Ser  Asp Ala Val Tyr His  Tyr Asp Tyr Val His  Ser Val Arg 
    4910                 4915                 4920             


Gly Lys  Val Ala Pro Thr Thr  Lys Thr Val Asp Leu  Asp Arg Ala 
    4925                 4930                 4935             


Leu His  Ala Tyr Lys Leu Gln  Ser Ser Asn Leu Tyr  Lys Thr Ser 
    4940                 4945                 4950             


Leu Arg  Thr Leu Pro Thr Gly  Tyr Arg Leu Pro Gly  Asp Thr Pro 
    4955                 4960                 4965             


His Phe  Lys His Ile Lys Asp  Thr Arg Tyr Met Ser  Ser Tyr Phe 
    4970                 4975                 4980             


Lys Tyr  Lys Glu Ala Tyr Glu  His Thr Lys Ala Tyr  Gly Tyr Thr 
    4985                 4990                 4995             


Leu Gly  Pro Lys Asp Val Pro  Phe Val His Val Arg  Arg Val Asn 
    5000                 5005                 5010             


Asn Val  Thr Ser Glu Arg Leu  Tyr Arg Glu Leu Tyr  His Lys Leu 
    5015                 5020                 5025             


Lys Asp  Lys Ile His Thr Thr  Pro Asp Thr Pro Glu  Ile Arg Gln 
    5030                 5035                 5040             


Val Lys  Lys Thr Gln Glu Ala  Val Ser Glu Leu Ile  Tyr Lys Ser 
    5045                 5050                 5055             


Asp Phe  Phe Lys Met Gln Gly  His Met Ile Ser Leu  Pro Tyr Thr 
    5060                 5065                 5070             


Pro Gln  Val Ile His Cys Arg  Tyr Val Gly Asp Ile  Thr Ser Asp 
    5075                 5080                 5085             


Ile Lys  Tyr Lys Glu Asp Leu  Gln Val Leu Lys Gly  Phe Gly Cys 
    5090                 5095                 5100             


Phe Leu  Tyr Asp Thr Pro Asp  Met Val Arg Ser Arg  His Leu Arg 
    5105                 5110                 5115             


Lys Leu  Trp Ser Asn Tyr Leu  Tyr Thr Asp Lys Ala  Arg Lys Met 
    5120                 5125                 5130             


Arg Asp  Lys Tyr Lys Val Val  Leu Asp Thr Pro Glu  Tyr Arg Lys 
    5135                 5140                 5145             


Val Gln  Glu Leu Lys Thr His  Leu Ser Glu Leu Val  Tyr Arg Ala 
    5150                 5155                 5160             


Ala Gly  Lys Lys Gln Lys Ser  Ile Phe Thr Ser Val  Pro Asp Thr 
    5165                 5170                 5175             


Pro Asp  Leu Leu Arg Ala Lys  Arg Gly Gln Lys Leu  Gln Ser Gln 
    5180                 5185                 5190             


Tyr Leu  Tyr Val Glu Leu Ala  Thr Lys Glu Arg Pro  His His His 
    5195                 5200                 5205             


Ala Gly  Asn Gln Thr Thr Ala  Leu Lys His Ala Lys  Asp Val Lys 
    5210                 5215                 5220             


Asp Met  Val Ser Glu Lys Lys  Tyr Lys Ile Gln Tyr  Glu Lys Met 
    5225                 5230                 5235             


Lys Asp  Lys Tyr Thr Pro Val  Pro Asp Thr Pro Ile  Leu Ile Arg 
    5240                 5245                 5250             


Ala Lys  Arg Ala Tyr Trp Asn  Ala Ser Asp Leu Arg  Tyr Lys Glu 
    5255                 5260                 5265             


Thr Phe  Gln Lys Thr Lys Gly  Lys Tyr His Thr Val  Lys Asp Ala 
    5270                 5275                 5280             


Leu Asp  Ile Val Tyr His Arg  Lys Val Thr Asp Asp  Ile Ser Lys 
    5285                 5290                 5295             


Ile Lys  Tyr Lys Glu Asn Tyr  Met Ser Gln Leu Gly  Ile Trp Arg 
    5300                 5305                 5310             


Ser Ile  Pro Asp Arg Pro Glu  His Phe His His Arg  Ala Val Thr 
    5315                 5320                 5325             


Asp Thr  Val Ser Asp Val Lys  Tyr Lys Glu Asp Leu  Thr Trp Leu 
    5330                 5335                 5340             


Lys Gly  Ile Gly Cys Tyr Ala  Tyr Asp Thr Pro Asp  Phe Thr Leu 
    5345                 5350                 5355             


Ala Glu  Lys Asn Lys Thr Leu  Tyr Ser Lys Tyr Lys  Tyr Lys Glu 
    5360                 5365                 5370             


Val Phe  Glu Arg Thr Lys Ser  Asp Phe Lys Tyr Val  Ala Asp Ser 
    5375                 5380                 5385             


Pro Ile  Asn Arg His Phe Lys  Tyr Ala Thr Gln Leu  Met Asn Glu 
    5390                 5395                 5400             


Lys Lys  Tyr Arg Ala Asp Tyr  Glu Gln Arg Lys Asp  Lys Tyr His 
    5405                 5410                 5415             


Leu Val  Val Asp Glu Pro Arg  His Leu Leu Ala Lys  Thr Ala Gly 
    5420                 5425                 5430             


Asp Gln  Ile Ser Gln Ile Lys  Tyr Arg Lys Asn Tyr  Glu Lys Ser 
    5435                 5440                 5445             


Lys Asp  Lys Phe Thr Ser Ile  Val Asp Thr Pro Glu  His Leu Arg 
    5450                 5455                 5460             


Thr Thr  Lys Val Asn Lys Gln  Ile Ser Asp Ile Leu  Tyr Lys Leu 
    5465                 5470                 5475             


Glu Tyr  Asn Lys Ala Lys Pro  Arg Gly Tyr Thr Thr  Ile His Asp 
    5480                 5485                 5490             


Thr Pro  Met Leu Leu His Val  Arg Lys Val Lys Asp  Glu Val Ser 
    5495                 5500                 5505             


Asp Leu  Lys Tyr Lys Glu Val  Tyr Gln Arg Asn Lys  Ser Asn Cys 
    5510                 5515                 5520             


Thr Ile  Glu Pro Asp Ala Val  His Ile Lys Ala Ala  Lys Asp Ala 
    5525                 5530                 5535             


Tyr Lys  Val Asn Thr Asn Leu  Asp Tyr Lys Lys Gln  Tyr Glu Ala 
    5540                 5545                 5550             


Asn Lys  Ala His Trp Lys Trp  Thr Pro Asp Arg Pro  Asp Phe Leu 
    5555                 5560                 5565             


Gln Ala  Ala Lys Ser Ser Leu  Gln Gln Ser Asp Phe  Glu Tyr Lys 
    5570                 5575                 5580             


Leu Asp  Arg Glu Phe Leu Lys  Gly Cys Lys Leu Ser  Val Thr Asp 
    5585                 5590                 5595             


Asp Lys  Asn Thr Val Leu Ala  Leu Arg Asn Thr Leu  Ile Glu Ser 
    5600                 5605                 5610             


Asp Leu  Lys Tyr Lys Glu Lys  His Val Lys Glu Arg  Gly Thr Cys 
    5615                 5620                 5625             


His Ala  Val Pro Asp Thr Pro  Gln Ile Leu Leu Ala  Lys Thr Val 
    5630                 5635                 5640             


Ser Asn  Leu Val Ser Glu Asn  Lys Tyr Lys Asp His  Val Lys Lys 
    5645                 5650                 5655             


His Leu  Ala Gln Gly Ser Tyr  Thr Thr Leu Pro Glu  Thr Arg Asp 
    5660                 5665                 5670             


Thr Val  His Val Lys Glu Val  Thr Lys His Val Ser  Asp Thr Asn 
    5675                 5680                 5685             


Tyr Lys  Lys Lys Phe Val Lys  Glu Lys Gly Lys Ser  Asn Tyr Ser 
    5690                 5695                 5700             


Ile Met  Leu Glu Pro Pro Glu  Val Lys His Ala Met  Glu Val Ala 
    5705                 5710                 5715             


Lys Lys  Gln Ser Asp Val Ala  Tyr Arg Lys Asp Ala  Lys Glu Asn 
    5720                 5725                 5730             


Leu His  Tyr Thr Thr Val Ala  Asp Arg Pro Asp Ile  Lys Lys Ala 
    5735                 5740                 5745             


Thr Gln  Ala Ala Lys Gln Ala  Ser Glu Val Glu Tyr  Arg Ala Lys 
    5750                 5755                 5760             


His Arg  Lys Glu Gly Ser His  Gly Leu Ser Met Leu  Gly Arg Pro 
    5765                 5770                 5775             


Asp Ile  Glu Met Ala Lys Lys  Ala Ala Lys Leu Ser  Ser Gln Val 
    5780                 5785                 5790             


Lys Tyr  Arg Glu Asn Phe Asp  Lys Glu Lys Gly Lys  Thr Pro Lys 
    5795                 5800                 5805             


Tyr Asn  Pro Lys Asp Ser Gln  Leu Tyr Lys Val Met  Lys Asp Ala 
    5810                 5815                 5820             


Asn Asn  Leu Ala Ser Glu Val  Lys Tyr Lys Ala Asp  Leu Lys Lys 
    5825                 5830                 5835             


Leu His  Lys Pro Val Thr Asp  Met Lys Glu Ser Leu  Ile Met Asn 
    5840                 5845                 5850             


His Val  Leu Asn Thr Ser Gln  Leu Ala Ser Ser Tyr  Gln Tyr Lys 
    5855                 5860                 5865             


Lys Lys  Tyr Glu Lys Ser Lys  Gly His Tyr His Thr  Ile Pro Asp 
    5870                 5875                 5880             


Asn Leu  Glu Gln Leu His Leu  Lys Glu Ala Thr Glu  Leu Gln Ser 
    5885                 5890                 5895             


Ile Val  Lys Tyr Lys Glu Lys  Tyr Glu Lys Glu Arg  Gly Lys Pro 
    5900                 5905                 5910             


Met Leu  Asp Phe Glu Thr Pro  Thr Tyr Ile Thr Ala  Lys Glu Ser 
    5915                 5920                 5925             


Gln Gln  Met Gln Ser Gly Lys  Glu Tyr Arg Lys Asp  Tyr Glu Glu 
    5930                 5935                 5940             


Ser Ile  Lys Gly Arg Asn Leu  Thr Gly Leu Glu Val  Thr Pro Ala 
    5945                 5950                 5955             


Leu Leu  His Val Lys Tyr Ala  Thr Lys Ile Ala Ser  Glu Lys Glu 
    5960                 5965                 5970             


Tyr Arg  Lys Asp Leu Glu Glu  Ser Ile Arg Gly Lys  Gly Leu Thr 
    5975                 5980                 5985             


Glu Met  Glu Asp Thr Pro Asp  Met Leu Arg Ala Lys  Asn Ala Thr 
    5990                 5995                 6000             


Gln Ile  Leu Asn Glu Lys Glu  Tyr Lys Arg Asp Leu  Glu Leu Glu 
    6005                 6010                 6015             


Val Lys  Gly Arg Gly Leu Asn  Ala Met Ala Asn Glu  Thr Pro Asp 
    6020                 6025                 6030             


Phe Met  Arg Ala Arg Asn Ala  Thr Asp Ile Ala Ser  Gln Ile Lys 
    6035                 6040                 6045             


Tyr Lys  Gln Ser Ala Glu Met  Glu Lys Ala Asn Phe  Thr Ser Val 
    6050                 6055                 6060             


Val Asp  Thr Pro Glu Ile Ile  His Ala Gln Gln Val  Lys Asn Leu 
    6065                 6070                 6075             


Ser Ser  Gln Lys Lys Tyr Lys  Glu Asp Ala Glu Lys  Ser Met Ser 
    6080                 6085                 6090             


Tyr Tyr  Glu Thr Val Leu Asp  Thr Pro Glu Ile Gln  Arg Val Arg 
    6095                 6100                 6105             


Glu Asn  Gln Lys Asn Phe Ser  Leu Leu Gln Tyr Gln  Cys Asp Leu 
    6110                 6115                 6120             


Lys Asn  Ser Lys Gly Lys Ile  Thr Val Val Gln Asp  Thr Pro Glu 
    6125                 6130                 6135             


Ile Leu  Arg Val Lys Glu Asn  Gln Lys Asn Phe Ser  Ser Val Leu 
    6140                 6145                 6150             


Tyr Lys  Glu Asp Val Ser Pro  Gly Thr Ala Ile Gly  Lys Thr Pro 
    6155                 6160                 6165             


Glu Met  Met Arg Val Lys Gln  Thr Gln Asp His Ile  Ser Ser Val 
    6170                 6175                 6180             


Lys Tyr  Lys Glu Ala Ile Gly  Gln Gly Thr Pro Ile  Pro Asp Leu 
    6185                 6190                 6195             


Pro Glu  Val Lys Arg Val Lys  Glu Thr Gln Lys His  Ile Ser Ser 
    6200                 6205                 6210             


Val Met  Tyr Lys Glu Asn Leu  Gly Thr Gly Ile Pro  Thr Thr Val 
    6215                 6220                 6225             


Thr Pro  Glu Ile Glu Arg Val  Lys Arg Asn Gln Glu  Asn Phe Ser 
    6230                 6235                 6240             


Ser Val  Leu Tyr Lys Glu Asn  Leu Gly Lys Gly Ile  Pro Thr Pro 
    6245                 6250                 6255             


Ile Thr  Pro Glu Met Glu Arg  Val Lys Arg Asn Gln  Glu Asn Phe 
    6260                 6265                 6270             


Ser Ser  Val Leu Tyr Lys Glu  Asn Met Gly Lys Gly  Thr Pro Leu 
    6275                 6280                 6285             


Ala Val  Thr Pro Glu Met Glu  Arg Val Lys His Asn  Gln Glu Asn 
    6290                 6295                 6300             


Ile Ser  Ser Val Leu Tyr Lys  Glu Asn Val Gly Lys  Ala Thr Ala 
    6305                 6310                 6315             


Thr Pro  Val Thr Pro Glu Met  Gln Arg Val Lys Arg  Asn Gln Glu 
    6320                 6325                 6330             


Asn Ile  Ser Ser Val Leu Tyr  Lys Glu Asn Leu Gly  Lys Ala Thr 
    6335                 6340                 6345             


Pro Thr  Pro Phe Thr Pro Glu  Met Glu Arg Val Lys  Arg Asn Gln 
    6350                 6355                 6360             


Glu Asn  Phe Ser Ser Val Leu  Tyr Lys Glu Asn Met  Arg Lys Ala 
    6365                 6370                 6375             


Thr Pro  Thr Pro Val Thr Pro  Glu Met Glu Arg Ala  Lys Arg Asn 
    6380                 6385                 6390             


Gln Glu  Asn Ile Ser Ser Val  Leu Tyr Ser Asp Ser  Phe Arg Lys 
    6395                 6400                 6405             


Gln Ile  Gln Gly Lys Ala Ala  Tyr Val Leu Asp Thr  Pro Glu Met 
    6410                 6415                 6420             


Arg Arg  Val Arg Glu Thr Gln  Arg His Ile Ser Thr  Val Lys Tyr 
    6425                 6430                 6435             


His Glu  Asp Phe Glu Lys His  Lys Gly Cys Phe Thr  Pro Val Val 
    6440                 6445                 6450             


Thr Asp  Pro Ile Thr Glu Arg  Val Lys Lys Asn Met  Gln Asp Phe 
    6455                 6460                 6465             


Ser Asp  Ile Asn Tyr Arg Gly  Ile Gln Arg Lys Val  Val Glu Met 
    6470                 6475                 6480             


Glu Gln  Lys Arg Asn Asp Gln  Asp Gln Glu Thr Ile  Thr Gly Leu 
    6485                 6490                 6495             


Arg Val  Trp Arg Thr Asn Pro  Gly Ser Val Phe Asp  Tyr Asp Pro 
    6500                 6505                 6510             


Ala Glu  Asp Asn Ile Gln Ser  Arg Ser Leu His Met  Ile Asn Val 
    6515                 6520                 6525             


Gln Ala  Gln Arg Arg Ser Arg  Glu Gln Ser Arg Ser  Ala Ser Ala 
    6530                 6535                 6540             


Leu Ser  Ile Ser Gly Gly Glu  Glu Lys Ser Glu His  Ser Glu Ala 
    6545                 6550                 6555             


Pro Asp  His His Leu Ser Thr  Tyr Ser Asp Gly Gly  Val Phe Ala 
    6560                 6565                 6570             


Val Ser  Thr Ala Tyr Lys His  Ala Lys Thr Thr Glu  Leu Pro Gln 
    6575                 6580                 6585             


Gln Arg  Ser Ser Ser Val Ala  Thr Gln Gln Thr Thr  Val Ser Ser 
    6590                 6595                 6600             


Ile Pro  Ser His Pro Ser Thr  Ala Gly Lys Ile Phe  Arg Ala Met 
    6605                 6610                 6615             


Tyr Asp  Tyr Met Ala Ala Asp  Ala Asp Glu Val Ser  Phe Lys Asp 
    6620                 6625                 6630             


Gly Asp  Ala Ile Ile Asn Val  Gln Ala Ile Asp Glu  Gly Trp Met 
    6635                 6640                 6645             


Tyr Gly  Thr Val Gln Arg Thr  Gly Arg Thr Gly Met  Leu Pro Ala 
    6650                 6655                 6660             


Asn Tyr  Val Glu Ala Ile 
    6665                 


<210>  30
<211>  902
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gly Ala Ala Ser Cys Glu Asp Glu Glu Leu Glu Phe Lys Leu Val 
1               5                   10                  15      


Phe Gly Glu Glu Lys Glu Ala Pro Pro Leu Gly Ala Gly Gly Leu Gly 
            20                  25                  30          


Glu Glu Leu Asp Ser Glu Asp Ala Pro Pro Cys Cys Arg Leu Ala Leu 
        35                  40                  45              


Gly Glu Pro Pro Pro Tyr Gly Ala Ala Pro Ile Gly Ile Pro Arg Pro 
    50                  55                  60                  


Pro Pro Pro Arg Pro Gly Met His Ser Pro Pro Pro Arg Pro Ala Pro 
65                  70                  75                  80  


Ser Pro Gly Thr Trp Glu Ser Gln Pro Ala Arg Ser Val Arg Leu Gly 
                85                  90                  95      


Gly Pro Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Arg Val Leu Glu 
            100                 105                 110         


Cys Pro Ser Ile Arg Ile Thr Ser Ile Ser Pro Thr Pro Glu Pro Pro 
        115                 120                 125             


Ala Ala Leu Glu Asp Asn Pro Asp Ala Trp Gly Asp Gly Ser Pro Arg 
    130                 135                 140                 


Asp Tyr Pro Pro Pro Glu Gly Phe Gly Gly Tyr Arg Glu Ala Gly Gly 
145                 150                 155                 160 


Gln Gly Gly Gly Ala Phe Phe Ser Pro Ser Pro Gly Ser Ser Ser Leu 
                165                 170                 175     


Ser Ser Trp Ser Phe Phe Ser Asp Ala Ser Asp Glu Ala Ala Leu Tyr 
            180                 185                 190         


Ala Ala Cys Asp Glu Val Glu Ser Glu Leu Asn Glu Ala Ala Ser Arg 
        195                 200                 205             


Phe Gly Leu Gly Ser Pro Leu Pro Ser Pro Arg Ala Ser Pro Arg Pro 
    210                 215                 220                 


Trp Thr Pro Glu Asp Pro Trp Ser Leu Tyr Gly Pro Ser Pro Gly Gly 
225                 230                 235                 240 


Arg Gly Pro Glu Asp Ser Trp Leu Leu Leu Ser Ala Pro Gly Pro Thr 
                245                 250                 255     


Pro Ala Ser Pro Arg Pro Ala Ser Pro Cys Gly Lys Arg Arg Tyr Ser 
            260                 265                 270         


Ser Ser Gly Thr Pro Ser Ser Ala Ser Pro Ala Leu Ser Arg Arg Gly 
        275                 280                 285             


Ser Leu Gly Glu Glu Gly Ser Glu Pro Pro Pro Pro Pro Pro Leu Pro 
    290                 295                 300                 


Leu Ala Arg Asp Pro Gly Ser Pro Gly Pro Phe Asp Tyr Val Gly Ala 
305                 310                 315                 320 


Pro Pro Ala Glu Ser Ile Pro Gln Lys Thr Arg Arg Thr Ser Ser Glu 
                325                 330                 335     


Gln Ala Val Ala Leu Pro Arg Ser Glu Glu Pro Ala Ser Cys Asn Gly 
            340                 345                 350         


Lys Leu Pro Leu Gly Ala Glu Glu Ser Val Ala Pro Pro Gly Gly Ser 
        355                 360                 365             


Arg Lys Glu Val Ala Gly Met Asp Tyr Leu Ala Val Pro Ser Pro Leu 
    370                 375                 380                 


Ala Trp Ser Lys Ala Arg Ile Gly Gly His Ser Pro Ile Phe Arg Thr 
385                 390                 395                 400 


Ser Ala Leu Pro Pro Leu Asp Trp Pro Leu Pro Ser Gln Tyr Glu Gln 
                405                 410                 415     


Leu Glu Leu Arg Ile Glu Val Gln Pro Arg Ala His His Arg Ala His 
            420                 425                 430         


Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Ala Pro Gly Gly 
        435                 440                 445             


His Pro Val Val Lys Leu Leu Gly Tyr Ser Glu Lys Pro Leu Thr Leu 
    450                 455                 460                 


Gln Met Phe Ile Gly Thr Ala Asp Glu Arg Asn Leu Arg Pro His Ala 
465                 470                 475                 480 


Phe Tyr Gln Val His Arg Ile Thr Gly Lys Met Val Ala Thr Ala Ser 
                485                 490                 495     


Tyr Glu Ala Val Val Ser Gly Thr Lys Val Leu Glu Met Thr Leu Leu 
            500                 505                 510         


Pro Glu Asn Asn Met Ala Ala Asn Ile Asp Cys Ala Gly Ile Leu Lys 
        515                 520                 525             


Leu Arg Asn Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly 
    530                 535                 540                 


Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln 
545                 550                 555                 560 


Gly Gly Gly Lys Val Val Ser Val Gln Ala Ala Ser Val Pro Ile Glu 
                565                 570                 575     


Cys Ser Gln Arg Ser Ala Gln Glu Leu Pro Gln Val Glu Ala Tyr Ser 
            580                 585                 590         


Pro Ser Ala Cys Ser Val Arg Gly Gly Glu Glu Leu Val Leu Thr Gly 
        595                 600                 605             


Ser Asn Phe Leu Pro Asp Ser Lys Val Val Phe Ile Glu Arg Gly Pro 
    610                 615                 620                 


Asp Gly Lys Leu Gln Trp Glu Glu Glu Ala Thr Val Asn Arg Leu Gln 
625                 630                 635                 640 


Ser Asn Glu Val Thr Leu Thr Leu Thr Val Pro Glu Tyr Ser Asn Lys 
                645                 650                 655     


Arg Val Ser Arg Pro Val Gln Val Tyr Phe Tyr Val Ser Asn Gly Arg 
            660                 665                 670         


Arg Lys Arg Ser Pro Thr Gln Ser Phe Arg Phe Leu Pro Val Ile Cys 
        675                 680                 685             


Lys Glu Glu Pro Leu Pro Asp Ser Ser Leu Arg Gly Phe Pro Ser Ala 
    690                 695                 700                 


Ser Ala Thr Pro Phe Gly Thr Asp Met Asp Phe Ser Pro Pro Arg Pro 
705                 710                 715                 720 


Pro Tyr Pro Ser Tyr Pro His Glu Asp Pro Ala Cys Glu Thr Pro Tyr 
                725                 730                 735     


Leu Ser Glu Gly Phe Gly Tyr Gly Met Pro Pro Leu Tyr Pro Gln Thr 
            740                 745                 750         


Gly Pro Pro Pro Ser Tyr Arg Pro Gly Leu Arg Met Phe Pro Glu Thr 
        755                 760                 765             


Arg Gly Thr Thr Gly Cys Ala Gln Pro Pro Ala Val Ser Phe Leu Pro 
    770                 775                 780                 


Arg Pro Phe Pro Ser Asp Pro Tyr Gly Gly Arg Gly Ser Ser Phe Ser 
785                 790                 795                 800 


Leu Gly Leu Pro Phe Ser Pro Pro Ala Pro Phe Arg Pro Pro Pro Leu 
                805                 810                 815     


Pro Ala Ser Pro Pro Leu Glu Gly Pro Phe Pro Ser Gln Ser Asp Val 
            820                 825                 830         


His Pro Leu Pro Ala Glu Gly Tyr Asn Lys Val Gly Pro Gly Tyr Gly 
        835                 840                 845             


Pro Gly Glu Gly Ala Pro Glu Gln Glu Lys Ser Arg Gly Gly Tyr Ser 
    850                 855                 860                 


Ser Gly Phe Arg Asp Ser Val Pro Ile Gln Gly Ile Thr Leu Glu Glu 
865                 870                 875                 880 


Val Ser Glu Ile Ile Gly Arg Asp Leu Ser Gly Phe Pro Ala Pro Pro 
                885                 890                 895     


Gly Glu Glu Pro Pro Ala 
            900         


<210>  31
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Ser Lys Arg Ala Leu Val Ile Leu Ala Lys Gly Ala Glu Glu 
1               5                   10                  15      


Met Glu Thr Val Ile Pro Val Asp Val Met Arg Arg Ala Gly Ile Lys 
            20                  25                  30          


Val Thr Val Ala Gly Leu Ala Gly Lys Asp Pro Val Gln Cys Ser Arg 
        35                  40                  45              


Asp Val Val Ile Cys Pro Asp Ala Ser Leu Glu Asp Ala Lys Lys Glu 
    50                  55                  60                  


Gly Pro Tyr Asp Val Val Val Leu Pro Gly Gly Asn Leu Gly Ala Gln 
65                  70                  75                  80  


Asn Leu Ser Glu Ser Ala Ala Val Lys Glu Ile Leu Lys Glu Gln Glu 
                85                  90                  95      


Asn Arg Lys Gly Leu Ile Ala Ala Ile Cys Ala Gly Pro Thr Ala Leu 
            100                 105                 110         


Leu Ala His Glu Ile Gly Phe Gly Ser Lys Val Thr Thr His Pro Leu 
        115                 120                 125             


Ala Lys Asp Lys Met Met Asn Gly Gly His Tyr Thr Tyr Ser Glu Asn 
    130                 135                 140                 


Arg Val Glu Lys Asp Gly Leu Ile Leu Thr Ser Arg Gly Pro Gly Thr 
145                 150                 155                 160 


Ser Phe Glu Phe Ala Leu Ala Ile Val Glu Ala Leu Asn Gly Lys Glu 
                165                 170                 175     


Val Ala Ala Gln Val Lys Ala Pro Leu Val Leu Lys Asp 
            180                 185                 


<210>  32
<211>  1069
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Leu Arg Met Arg Thr Ala Gly Trp Ala Arg Gly Trp Cys Leu Gly 
1               5                   10                  15      


Cys Cys Leu Leu Leu Pro Leu Ser Leu Ser Leu Ala Ala Ala Lys Gln 
            20                  25                  30          


Leu Leu Arg Tyr Arg Leu Ala Glu Glu Gly Pro Ala Asp Val Arg Ile 
        35                  40                  45              


Gly Asn Val Ala Ser Asp Leu Gly Ile Val Thr Gly Ser Gly Glu Val 
    50                  55                  60                  


Thr Phe Ser Leu Glu Ser Gly Ser Glu Tyr Leu Lys Ile Asp Asn Leu 
65                  70                  75                  80  


Thr Gly Glu Leu Ser Thr Ser Glu Arg Arg Ile Asp Arg Glu Lys Leu 
                85                  90                  95      


Pro Gln Cys Gln Met Ile Phe Asp Glu Asn Glu Cys Phe Leu Asp Phe 
            100                 105                 110         


Glu Val Ser Val Ile Gly Pro Ser Gln Ser Trp Val Asp Leu Phe Glu 
        115                 120                 125             


Gly Gln Val Ile Val Leu Asp Ile Asn Asp Asn Thr Pro Thr Phe Pro 
    130                 135                 140                 


Ser Pro Val Leu Thr Leu Thr Val Glu Glu Asn Arg Pro Val Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Leu Pro Thr Ala Thr Asp Arg Asp Phe Gly Arg Asn Gly 
                165                 170                 175     


Ile Glu Arg Tyr Glu Leu Leu Gln Glu Pro Gly Gly Gly Gly Ser Gly 
            180                 185                 190         


Gly Glu Ser Arg Arg Ala Gly Ala Ala Asp Ser Ala Pro Tyr Pro Gly 
        195                 200                 205             


Gly Gly Gly Asn Gly Ala Ser Gly Gly Gly Ser Gly Gly Ser Lys Arg 
    210                 215                 220                 


Arg Leu Asp Ala Ser Glu Gly Gly Gly Gly Thr Asn Pro Gly Gly Arg 
225                 230                 235                 240 


Ser Ser Val Phe Glu Leu Gln Val Ala Asp Thr Pro Asp Gly Glu Lys 
                245                 250                 255     


Gln Pro Gln Leu Ile Val Lys Gly Ala Leu Asp Arg Glu Gln Arg Asp 
            260                 265                 270         


Ser Tyr Glu Leu Thr Leu Arg Val Arg Asp Gly Gly Asp Pro Pro Arg 
        275                 280                 285             


Ser Ser Gln Ala Ile Leu Arg Val Leu Ile Thr Asp Val Asn Asp Asn 
    290                 295                 300                 


Ser Pro Arg Phe Glu Lys Ser Val Tyr Glu Ala Asp Leu Ala Glu Asn 
305                 310                 315                 320 


Ser Ala Pro Gly Thr Pro Ile Leu Gln Leu Arg Ala Ala Asp Leu Asp 
                325                 330                 335     


Val Gly Val Asn Gly Gln Ile Glu Tyr Val Phe Gly Ala Ala Thr Glu 
            340                 345                 350         


Ser Val Arg Arg Leu Leu Arg Leu Asp Glu Thr Ser Gly Trp Leu Ser 
        355                 360                 365             


Val Leu His Arg Ile Asp Arg Glu Glu Val Asn Gln Leu Arg Phe Thr 
    370                 375                 380                 


Val Met Ala Arg Asp Arg Gly Gln Pro Pro Lys Thr Asp Lys Ala Thr 
385                 390                 395                 400 


Val Val Leu Asn Ile Lys Asp Glu Asn Asp Asn Val Pro Ser Ile Glu 
                405                 410                 415     


Ile Arg Lys Ile Gly Arg Ile Pro Leu Lys Asp Gly Val Ala Asn Val 
            420                 425                 430         


Ala Glu Asp Val Leu Val Asp Thr Pro Ile Ala Leu Val Gln Val Ser 
        435                 440                 445             


Asp Arg Asp Gln Gly Glu Asn Gly Val Val Thr Cys Thr Val Val Gly 
    450                 455                 460                 


Asp Val Pro Phe Gln Leu Lys Pro Ala Ser Asp Thr Glu Gly Asp Gln 
465                 470                 475                 480 


Asn Lys Lys Lys Tyr Phe Leu His Thr Ser Thr Pro Leu Asp Tyr Glu 
                485                 490                 495     


Ala Thr Arg Glu Phe Asn Val Val Ile Val Ala Val Asp Ser Gly Ser 
            500                 505                 510         


Pro Ser Leu Ser Ser Asn Asn Ser Leu Ile Val Lys Val Gly Asp Thr 
        515                 520                 525             


Asn Asp Asn Pro Pro Met Phe Gly Gln Ser Val Val Glu Val Tyr Phe 
    530                 535                 540                 


Pro Glu Asn Asn Ile Pro Gly Glu Arg Val Ala Thr Val Leu Ala Thr 
545                 550                 555                 560 


Asp Ala Asp Ser Gly Lys Asn Ala Glu Ile Ala Tyr Ser Leu Asp Ser 
                565                 570                 575     


Ser Val Met Gly Ile Phe Ala Ile Asp Pro Asp Ser Gly Asp Ile Leu 
            580                 585                 590         


Val Asn Thr Val Leu Asp Arg Glu Gln Thr Asp Arg Tyr Glu Phe Lys 
        595                 600                 605             


Val Asn Ala Lys Asp Lys Gly Ile Pro Val Leu Gln Gly Ser Thr Thr 
    610                 615                 620                 


Val Ile Val Gln Val Ala Asp Lys Asn Asp Asn Asp Pro Lys Phe Met 
625                 630                 635                 640 


Gln Asp Val Phe Thr Phe Tyr Val Lys Glu Asn Leu Gln Pro Asn Ser 
                645                 650                 655     


Pro Val Gly Met Val Thr Val Met Asp Ala Asp Lys Gly Arg Asn Ala 
            660                 665                 670         


Glu Met Ser Leu Tyr Ile Glu Glu Asn Asn Asn Ile Phe Ser Ile Glu 
        675                 680                 685             


Asn Asp Thr Gly Thr Ile Tyr Ser Thr Met Ser Phe Asp Arg Glu His 
    690                 695                 700                 


Gln Thr Thr Tyr Thr Phe Arg Val Lys Ala Val Asp Gly Gly Asp Pro 
705                 710                 715                 720 


Pro Arg Ser Ala Thr Ala Thr Val Ser Leu Phe Val Met Asp Glu Asn 
                725                 730                 735     


Asp Asn Ala Pro Thr Val Thr Leu Pro Lys Asn Ile Ser Tyr Thr Leu 
            740                 745                 750         


Leu Pro Pro Ser Ser Asn Val Arg Thr Val Val Ala Thr Val Leu Ala 
        755                 760                 765             


Thr Asp Ser Asp Asp Gly Ile Asn Ala Asp Leu Asn Tyr Ser Ile Val 
    770                 775                 780                 


Gly Gly Asn Pro Phe Lys Leu Phe Glu Ile Asp Pro Thr Ser Gly Val 
785                 790                 795                 800 


Val Ser Leu Val Gly Lys Leu Thr Gln Lys His Tyr Gly Leu His Arg 
                805                 810                 815     


Leu Val Val Gln Val Asn Asp Ser Gly Gln Pro Ser Gln Ser Thr Thr 
            820                 825                 830         


Thr Leu Val His Val Phe Val Asn Glu Ser Val Ser Asn Ala Thr Ala 
        835                 840                 845             


Ile Asp Ser Gln Ile Ala Arg Ser Leu His Ile Pro Leu Thr Gln Asp 
    850                 855                 860                 


Ile Ala Gly Asp Pro Ser Tyr Glu Ile Ser Lys Gln Arg Leu Ser Ile 
865                 870                 875                 880 


Val Ile Gly Val Val Ala Gly Ile Met Thr Val Ile Leu Ile Ile Leu 
                885                 890                 895     


Ile Val Val Met Ala Arg Tyr Cys Arg Ser Lys Asn Lys Asn Gly Tyr 
            900                 905                 910         


Glu Ala Gly Lys Lys Asp His Glu Asp Phe Phe Thr Pro Gln Gln His 
        915                 920                 925             


Asp Lys Ser Lys Lys Pro Lys Lys Asp Lys Lys Asn Lys Lys Ser Lys 
    930                 935                 940                 


Gln Pro Leu Tyr Ser Ser Ile Val Thr Val Glu Ala Ser Lys Pro Asn 
945                 950                 955                 960 


Gly Gln Arg Tyr Asp Ser Val Asn Glu Lys Leu Ser Asp Ser Pro Ser 
                965                 970                 975     


Met Gly Arg Tyr Arg Ser Val Asn Gly Gly Pro Gly Ser Pro Asp Leu 
            980                 985                 990         


Ala Arg His Tyr Lys Ser Ser Ser  Pro Leu Pro Thr Val  Gln Leu His 
        995                 1000                 1005             


Pro Gln  Ser Pro Thr Ala Gly  Lys Lys His Gln Ala  Val Gln Asp 
    1010                 1015                 1020             


Leu Pro  Pro Ala Asn Thr Phe  Val Gly Ala Gly Asp  Asn Ile Ser 
    1025                 1030                 1035             


Ile Gly  Ser Asp His Cys Ser  Glu Tyr Ser Cys Gln  Thr Asn Asn 
    1040                 1045                 1050             


Lys Tyr  Ser Lys Gln Met Arg  Leu His Pro Tyr Ile  Thr Val Phe 
    1055                 1060                 1065             


Gly 
    


<210>  33
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys Gly 
1               5                   10                  15      


Lys Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn Asn 
            20                  25                  30          


Gln Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile Lys 
        35                  40                  45              


Phe Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu Met Ser His Leu 
    50                  55                  60                  


Gly Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro 
65                  70                  75                  80  


Val Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu 
                85                  90                  95      


Lys Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys Ala Asn Pro Ala 
            100                 105                 110         


Ala Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu 
        115                 120                 125             


Glu Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu Pro 
    130                 135                 140                 


Ala Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val 
145                 150                 155                 160 


Tyr Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met 
                165                 170                 175     


Val Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys 
            180                 185                 190         


Glu Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe 
        195                 200                 205             


Leu Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile 
    210                 215                 220                 


Asn Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met 
225                 230                 235                 240 


Ala Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser 
                245                 250                 255     


Leu Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Ser Lys 
            260                 265                 270         


Ala Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val Thr 
        275                 280                 285             


Ala Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val Ala 
    290                 295                 300                 


Ser Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Pro Glu Ser 
305                 310                 315                 320 


Ser Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys Gln Ile Val Trp 
                325                 330                 335     


Asn Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr 
            340                 345                 350         


Lys Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys Ile 
        355                 360                 365             


Thr Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn 
    370                 375                 380                 


Thr Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu 
385                 390                 395                 400 


Glu Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala Leu Ser Asn 
                405                 410                 415     


Ile 
    


<210>  34
<211>  1075
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Val Val Glu Val Asp Ser Met Pro Ala Ala Ser Ser Val Lys Lys 
1               5                   10                  15      


Pro Phe Gly Leu Arg Ser Lys Met Gly Lys Trp Cys Cys Arg Cys Phe 
            20                  25                  30          


Pro Cys Tyr Arg Glu Ser Gly Lys Ser Asn Val Gly Thr Ser Gly Asp 
        35                  40                  45              


His Asp Asp Ser Ala Met Lys Thr Leu Arg Ser Lys Met Gly Lys Trp 
    50                  55                  60                  


Cys His His Cys Phe Pro Cys Cys Arg Gly Ser Gly Lys Ser Asn Val 
65                  70                  75                  80  


Gly Ala Ser Gly Asp His Asp Asp Ser Ala Met Lys Thr Leu Arg Asn 
                85                  90                  95      


Lys Met Gly Lys Trp Cys Cys His Cys Phe Pro Cys Cys Arg Gly Ser 
            100                 105                 110         


Gly Lys Ser Lys Val Gly Ala Trp Gly Asp Tyr Asp Asp Ser Ala Phe 
        115                 120                 125             


Met Glu Pro Arg Tyr His Val Arg Gly Glu Asp Leu Asp Lys Leu His 
    130                 135                 140                 


Arg Ala Ala Trp Trp Gly Lys Val Pro Arg Lys Asp Leu Ile Val Met 
145                 150                 155                 160 


Leu Arg Asp Thr Asp Val Asn Lys Lys Asp Lys Gln Lys Arg Thr Ala 
                165                 170                 175     


Leu His Leu Ala Ser Ala Asn Gly Asn Ser Glu Val Val Lys Leu Leu 
            180                 185                 190         


Leu Asp Arg Arg Cys Gln Leu Asn Val Leu Asp Asn Lys Lys Arg Thr 
        195                 200                 205             


Ala Leu Ile Lys Ala Val Gln Cys Gln Glu Asp Glu Cys Ala Leu Met 
    210                 215                 220                 


Leu Leu Glu His Gly Thr Asp Pro Asn Ile Pro Asp Glu Tyr Gly Asn 
225                 230                 235                 240 


Thr Thr Leu His Tyr Ala Ile Tyr Asn Glu Asp Lys Leu Met Ala Lys 
                245                 250                 255     


Ala Leu Leu Leu Tyr Gly Ala Asp Ile Glu Ser Lys Asn Lys His Gly 
            260                 265                 270         


Leu Thr Pro Leu Leu Leu Gly Val His Glu Gln Lys Gln Gln Val Val 
        275                 280                 285             


Lys Phe Leu Ile Lys Lys Lys Ala Asn Leu Asn Ala Leu Asp Arg Tyr 
    290                 295                 300                 


Gly Arg Thr Ala Leu Ile Leu Ala Val Cys Cys Gly Ser Ala Ser Ile 
305                 310                 315                 320 


Val Ser Leu Leu Leu Glu Gln Asn Ile Asp Val Ser Ser Gln Asp Leu 
                325                 330                 335     


Ser Gly Gln Thr Ala Arg Glu Tyr Ala Val Ser Ser His His His Val 
            340                 345                 350         


Ile Cys Gln Leu Leu Ser Asp Tyr Lys Glu Lys Gln Met Leu Lys Ile 
        355                 360                 365             


Ser Ser Glu Asn Ser Asn Pro Glu Gln Glu Leu Lys Leu Thr Ser Glu 
    370                 375                 380                 


Glu Glu Ser Gln Arg Phe Lys Gly Ser Glu Asn Ser Gln Pro Glu Lys 
385                 390                 395                 400 


Met Ser Gln Glu Leu Glu Ile Asn Lys Asp Gly Asp Arg Glu Val Glu 
                405                 410                 415     


Glu Glu Met Lys Lys His Glu Ser Asn Asn Val Gly Leu Leu Glu Asn 
            420                 425                 430         


Leu Thr Asn Gly Val Thr Ala Gly Asn Gly Asp Asn Gly Leu Ile Pro 
        435                 440                 445             


Gln Arg Lys Ser Arg Thr Pro Glu Asn Gln Gln Phe Pro Asp Asn Glu 
    450                 455                 460                 


Ser Glu Glu Tyr His Arg Ile Cys Glu Leu Leu Ser Asp Tyr Lys Glu 
465                 470                 475                 480 


Lys Gln Met Pro Lys Tyr Ser Ser Glu Asn Ser Asn Pro Glu Gln Asp 
                485                 490                 495     


Leu Lys Leu Thr Ser Glu Glu Glu Ser Gln Arg Leu Lys Gly Ser Glu 
            500                 505                 510         


Asn Gly Gln Pro Glu Lys Arg Ser Gln Glu Pro Glu Ile Asn Lys Asp 
        515                 520                 525             


Gly Asp Arg Glu Leu Glu Asn Phe Met Ala Ile Glu Glu Met Lys Lys 
    530                 535                 540                 


His Gly Ser Thr His Val Gly Phe Pro Glu Asn Leu Thr Asn Gly Ala 
545                 550                 555                 560 


Thr Ala Gly Asn Gly Asp Asp Gly Leu Ile Pro Pro Arg Lys Ser Arg 
                565                 570                 575     


Thr Pro Glu Ser Gln Gln Phe Pro Asp Thr Glu Asn Glu Glu Tyr His 
            580                 585                 590         


Ser Asp Glu Gln Asn Asp Thr Gln Lys Gln Phe Cys Glu Glu Gln Asn 
        595                 600                 605             


Thr Gly Ile Leu His Asp Glu Ile Leu Ile His Glu Glu Lys Gln Ile 
    610                 615                 620                 


Glu Val Val Glu Lys Met Asn Ser Glu Leu Ser Leu Ser Cys Lys Lys 
625                 630                 635                 640 


Glu Lys Asp Val Leu His Glu Asn Ser Thr Leu Arg Glu Glu Ile Ala 
                645                 650                 655     


Met Leu Arg Leu Glu Leu Asp Thr Met Lys His Gln Ser Gln Leu Arg 
            660                 665                 670         


Glu Lys Lys Tyr Leu Glu Asp Ile Glu Ser Val Lys Lys Lys Asn Asp 
        675                 680                 685             


Asn Leu Leu Lys Ala Leu Gln Leu Asn Glu Leu Thr Met Asp Asp Asp 
    690                 695                 700                 


Thr Ala Val Leu Val Ile Asp Asn Gly Ser Gly Met Cys Lys Ala Gly 
705                 710                 715                 720 


Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro Ser Ile Val Gly 
                725                 730                 735     


Arg Pro Arg Gln Gln Gly Met Met Gly Gly Met His Gln Lys Glu Ser 
            740                 745                 750         


Tyr Val Gly Lys Glu Ala Gln Ser Lys Arg Gly Ile Leu Thr Leu Lys 
        755                 760                 765             


Tyr Pro Met Glu His Gly Ile Ile Thr Asn Trp Asp Asp Met Glu Lys 
    770                 775                 780                 


Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu 
785                 790                 795                 800 


His Pro Ile Leu Leu Thr Glu Ala Pro Leu Asn Pro Lys Ala Asn Arg 
                805                 810                 815     


Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn Thr Pro Ala Met 
            820                 825                 830         


Tyr Val Ala Ile Gln Ala Val Pro Ser Leu Tyr Thr Ser Gly Arg Thr 
        835                 840                 845             


Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr His Thr Val Pro 
    850                 855                 860                 


Ile Tyr Glu Gly Asn Ala Leu Pro His Ala Thr Leu Arg Leu Asp Leu 
865                 870                 875                 880 


Ala Gly Arg Glu Leu Pro Asp Tyr Leu Met Lys Ile Leu Thr Glu Arg 
                885                 890                 895     


Gly Tyr Arg Phe Thr Thr Met Ala Glu Arg Glu Ile Val Arg Asp Ile 
            900                 905                 910         


Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu Gln Glu Met Ala 
        915                 920                 925             


Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr Glu Leu Pro Asp 
    930                 935                 940                 


Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg Cys Pro Glu Ala 
945                 950                 955                 960 


Leu Phe Gln Pro Cys Phe Leu Gly Met Glu Ser Cys Gly Ile His Glu 
                965                 970                 975     


Thr Thr Phe Asn Ser Ile Met Lys Ser Asp Val Asp Ile Arg Lys Asp 
            980                 985                 990         


Leu Tyr Thr Asn Thr Val Leu Ser  Gly Gly Thr Thr Met  Tyr Pro Gly 
        995                 1000                 1005             


Met Ala  His Arg Met Gln Lys  Glu Ile Ala Ala Leu  Ala Pro Ser 
    1010                 1015                 1020             


Met Met  Lys Ile Arg Ile Ile  Ala Pro Pro Lys Arg  Lys Tyr Ser 
    1025                 1030                 1035             


Val Trp  Val Gly Gly Ser Ile  Leu Ala Ser Leu Ser  Thr Phe Gln 
    1040                 1045                 1050             


Gln Met  Trp Ile Ser Lys Gln  Glu Tyr Asp Glu Ser  Gly Pro Ser 
    1055                 1060                 1065             


Ile Val  His Arg Lys Cys Phe  
    1070                 1075 


<210>  35
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Pro Asp Tyr Leu Gly Ala Asp Gln Arg Lys Thr Lys Glu Asp Glu 
1               5                   10                  15      


Lys Asp Asp Lys Pro Ile Arg Ala Leu Asp Glu Gly Asp Ile Ala Leu 
            20                  25                  30          


Leu Lys Thr Tyr Gly Gln Ser Thr Tyr Ser Arg Gln Ile Lys Gln Val 
        35                  40                  45              


Glu Asp Asp Ile Gln Gln Leu Leu Lys Lys Ile Asn Glu Leu Thr Gly 
    50                  55                  60                  


Ile Lys Glu Ser Asp Thr Gly Leu Ala Pro Pro Ala Leu Trp Asp Leu 
65                  70                  75                  80  


Ala Ala Asp Lys Gln Thr Leu Gln Ser Glu Gln Pro Leu Gln Val Ala 
                85                  90                  95      


Arg Cys Thr Lys Ile Ile Asn Ala Asp Ser Glu Asp Pro Lys Tyr Ile 
            100                 105                 110         


Ile Asn Val Lys Gln Phe Ala Lys Phe Val Val Asp Leu Ser Asp Gln 
        115                 120                 125             


Val Ala Pro Thr Asp Ile Glu Glu Gly Met Arg Val Gly Val Asp Arg 
    130                 135                 140                 


Asn Lys Tyr Gln Ile His Ile Pro Leu Pro Pro Lys Ile Asp Pro Thr 
145                 150                 155                 160 


Val Thr Met Met Gln Val Glu Glu Lys Pro Asp Val Thr Tyr Ser Asp 
                165                 170                 175     


Val Gly Gly Cys Lys Glu Gln Ile Glu Lys Leu Arg Glu Val Val Glu 
            180                 185                 190         


Thr Pro Leu Leu His Pro Glu Arg Phe Val Asn Leu Gly Ile Glu Pro 
        195                 200                 205             


Pro Lys Gly Val Leu Leu Phe Gly Pro Pro Gly Thr Gly Lys Thr Leu 
    210                 215                 220                 


Cys Ala Arg Ala Val Ala Asn Arg Thr Asp Ala Cys Phe Ile Arg Val 
225                 230                 235                 240 


Ile Gly Ser Glu Leu Val Gln Lys Tyr Val Gly Glu Gly Ala Arg Met 
                245                 250                 255     


Val Arg Glu Leu Phe Glu Met Ala Arg Thr Lys Lys Ala Cys Leu Ile 
            260                 265                 270         


Phe Phe Asp Glu Ile Asp Ala Ile Gly Gly Ala Arg Phe Asp Asp Gly 
        275                 280                 285             


Ala Gly Gly Asp Asn Glu Val Gln Arg Thr Met Leu Glu Leu Ile Asn 
    290                 295                 300                 


Gln Leu Asp Gly Phe Asp Pro Arg Gly Asn Ile Lys Val Leu Met Ala 
305                 310                 315                 320 


Thr Asn Arg Pro Asp Thr Leu Asp Pro Ala Leu Met Arg Pro Gly Arg 
                325                 330                 335     


Leu Asp Arg Lys Ile Glu Phe Ser Leu Pro Asp Leu Glu Gly Arg Thr 
            340                 345                 350         


His Ile Phe Lys Ile His Ala Arg Ser Met Ser Val Glu Arg Asp Ile 
        355                 360                 365             


Arg Phe Glu Leu Leu Ala Arg Leu Cys Pro Asn Ser Thr Gly Ala Glu 
    370                 375                 380                 


Ile Arg Ser Val Cys Thr Glu Ala Gly Met Phe Ala Ile Arg Ala Arg 
385                 390                 395                 400 


Arg Lys Ile Ala Thr Glu Lys Asp Phe Leu Glu Ala Val Asn Lys Val 
                405                 410                 415     


Ile Lys Ser Tyr Ala Lys Phe Ser Ala Thr Pro Arg Tyr Met Thr Tyr 
            420                 425                 430         


Asn 
    


<210>  36
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Asp Pro Gly Ala Ala Leu Gln Arg Arg Ala Gly Gly Gly Gly Gly 
1               5                   10                  15      


Leu Gly Ala Gly Ser Pro Ala Leu Ser Gly Gly Gln Gly Arg Arg Arg 
            20                  25                  30          


Lys Gln Pro Pro Arg Pro Ala Asp Phe Lys Leu Gln Val Ile Ile Ile 
        35                  40                  45              


Gly Ser Arg Gly Val Gly Lys Thr Ser Leu Met Glu Arg Phe Thr Asp 
    50                  55                  60                  


Asp Thr Phe Cys Glu Ala Cys Lys Ser Thr Val Gly Val Asp Phe Lys 
65                  70                  75                  80  


Ile Lys Thr Val Glu Leu Arg Gly Lys Lys Ile Arg Leu Gln Ile Trp 
                85                  90                  95      


Asp Thr Ala Gly Gln Glu Arg Phe Asn Ser Ile Thr Ser Ala Tyr Tyr 
            100                 105                 110         


Arg Ser Ala Lys Gly Ile Ile Leu Val Tyr Asp Ile Thr Lys Lys Glu 
        115                 120                 125             


Thr Phe Asp Asp Leu Pro Lys Trp Met Lys Met Ile Asp Lys Tyr Ala 
    130                 135                 140                 


Ser Glu Asp Ala Glu Leu Leu Leu Val Gly Asn Lys Leu Asp Cys Glu 
145                 150                 155                 160 


Thr Asp Arg Glu Ile Thr Arg Gln Gln Gly Glu Lys Phe Ala Gln Gln 
                165                 170                 175     


Ile Thr Gly Met Arg Phe Cys Glu Ala Ser Ala Lys Asp Asn Phe Asn 
            180                 185                 190         


Val Asp Glu Ile Phe Leu Lys Leu Val Asp Asp Ile Leu Lys Lys Met 
        195                 200                 205             


Pro Leu Asp Ile Leu Arg Asn Glu Leu Ser Asn Ser Ile Leu Ser Leu 
    210                 215                 220                 


Gln Pro Glu Pro Glu Ile Pro Pro Glu Leu Pro Pro Pro Arg Pro His 
225                 230                 235                 240 


Val Arg Cys Cys 
                


<210>  37
<211>  1550
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Glu Cys Pro Ser Cys Gln His Val Ser Lys Glu Glu Thr Pro Lys 
1               5                   10                  15      


Phe Cys Ser Gln Cys Gly Glu Arg Leu Pro Pro Ala Ala Pro Ile Ala 
            20                  25                  30          


Asp Ser Glu Asn Asn Asn Ser Thr Met Ala Ser Ala Ser Glu Gly Glu 
        35                  40                  45              


Met Glu Cys Gly Gln Glu Leu Lys Glu Glu Gly Gly Pro Cys Leu Phe 
    50                  55                  60                  


Pro Gly Ser Asp Ser Trp Gln Glu Asn Pro Glu Glu Pro Cys Ser Lys 
65                  70                  75                  80  


Ala Ser Trp Thr Val Gln Glu Ser Lys Lys Lys Lys Arg Lys Lys Lys 
                85                  90                  95      


Lys Lys Gly Asn Lys Ser Ala Ser Ser Glu Leu Ala Ser Leu Pro Leu 
            100                 105                 110         


Ser Pro Ala Ser Pro Cys His Leu Thr Leu Leu Ser Asn Pro Trp Pro 
        115                 120                 125             


Gln Asp Thr Ala Leu Pro His Ser Gln Ala Gln Gln Ser Gly Pro Thr 
    130                 135                 140                 


Gly Gln Pro Ser Gln Pro Pro Gly Thr Ala Thr Thr Pro Leu Glu Gly 
145                 150                 155                 160 


Asp Gly Leu Ser Ala Pro Thr Glu Val Gly Asp Ser Pro Leu Gln Ala 
                165                 170                 175     


Gln Ala Leu Gly Glu Ala Gly Val Ala Thr Gly Ser Glu Ala Gln Ser 
            180                 185                 190         


Ser Pro Gln Phe Gln Asp His Thr Glu Gly Glu Asp Gln Asp Ala Ser 
        195                 200                 205             


Ile Pro Ser Gly Gly Arg Gly Leu Ser Gln Glu Gly Thr Gly Pro Pro 
    210                 215                 220                 


Thr Ser Ala Gly Glu Gly His Ser Arg Thr Glu Asp Ala Ala Gln Glu 
225                 230                 235                 240 


Leu Leu Leu Pro Glu Ser Lys Gly Gly Ser Ser Glu Pro Gly Thr Glu 
                245                 250                 255     


Leu Gln Thr Thr Glu Gln Gln Ala Gly Ala Ser Ala Ser Met Ala Val 
            260                 265                 270         


Asp Ala Val Ala Glu Pro Ala Asn Ala Val Lys Gly Ala Gly Lys Glu 
        275                 280                 285             


Met Lys Glu Lys Thr Gln Arg Met Lys Gln Pro Pro Ala Thr Thr Pro 
    290                 295                 300                 


Pro Phe Lys Thr His Cys Gln Glu Ala Glu Thr Lys Thr Lys Asp Glu 
305                 310                 315                 320 


Met Ala Ala Ala Glu Glu Lys Val Gly Lys Asn Glu Gln Gly Glu Pro 
                325                 330                 335     


Glu Asp Leu Lys Lys Pro Glu Gly Lys Asn Arg Ser Ala Ala Ala Val 
            340                 345                 350         


Lys Asn Glu Lys Glu Gln Lys Asn Gln Glu Ala Asp Val Gln Glu Val 
        355                 360                 365             


Lys Ala Ser Thr Leu Ser Pro Gly Gly Gly Val Thr Val Phe Phe His 
    370                 375                 380                 


Ala Ile Ile Ser Leu His Phe Pro Phe Asn Pro Asp Leu His Lys Val 
385                 390                 395                 400 


Phe Ile Arg Gly Gly Glu Glu Phe Gly Glu Ser Lys Trp Asp Ser Asn 
                405                 410                 415     


Ile Cys Glu Leu His Tyr Thr Arg Asp Leu Gly His Asp Arg Val Leu 
            420                 425                 430         


Val Glu Gly Ile Val Cys Ile Ser Lys Lys His Leu Asp Lys Tyr Ile 
        435                 440                 445             


Pro Tyr Lys Tyr Val Ile Tyr Asn Gly Glu Ser Phe Glu Tyr Glu Phe 
    450                 455                 460                 


Ile Tyr Lys His Gln Gln Lys Lys Gly Glu Tyr Val Asn Arg Cys Leu 
465                 470                 475                 480 


Phe Ile Lys Ser Ser Leu Leu Gly Ser Gly Asp Trp His Gln Tyr Tyr 
                485                 490                 495     


Asp Ile Val Tyr Met Lys Pro His Gly Arg Leu Gln Lys Val Met Asn 
            500                 505                 510         


His Ile Thr Asp Gly Pro Arg Lys Asp Leu Val Lys Gly Lys Gln Ile 
        515                 520                 525             


Ala Ala Ala Leu Met Leu Asp Ser Thr Phe Ser Ile Leu Gln Thr Trp 
    530                 535                 540                 


Asp Thr Ile Asn Leu Asn Ser Phe Phe Thr Gln Phe Glu Gln Phe Cys 
545                 550                 555                 560 


Phe Val Leu Gln Gln Pro Met Ile Tyr Glu Gly Gln Ala Gln Leu Trp 
                565                 570                 575     


Thr Asp Leu Gln Tyr Arg Glu Lys Glu Val Lys Arg Tyr Leu Trp Gln 
            580                 585                 590         


His Leu Lys Lys His Val Val Pro Leu Pro Asp Gly Lys Ser Thr Asp 
        595                 600                 605             


Phe Leu Pro Val Asp Cys Pro Val Arg Ser Lys Leu Lys Thr Gly Leu 
    610                 615                 620                 


Ile Val Leu Phe Val Val Glu Lys Ile Glu Leu Leu Leu Glu Gly Ser 
625                 630                 635                 640 


Leu Asp Trp Leu Cys His Leu Leu Thr Ser Asp Ala Ser Ser Pro Asp 
                645                 650                 655     


Glu Phe His Arg Asp Leu Ser His Ile Leu Gly Ile Pro Gln Ser Trp 
            660                 665                 670         


Arg Leu Tyr Leu Val Asn Leu Cys Gln Arg Cys Met Asp Thr Arg Thr 
        675                 680                 685             


Tyr Thr Trp Leu Gly Ala Leu Pro Val Leu His Cys Cys Met Glu Leu 
    690                 695                 700                 


Ala Pro Arg His Lys Asp Ala Trp Arg Gln Pro Glu Asp Thr Trp Ala 
705                 710                 715                 720 


Ala Leu Glu Gly Leu Ser Phe Ser Pro Phe Arg Glu Gln Met Leu Asp 
                725                 730                 735     


Thr Ser Ser Leu Leu Gln Phe Met Arg Glu Lys Gln His Leu Leu Ser 
            740                 745                 750         


Ile Asp Glu Pro Leu Phe Arg Ser Trp Phe Ser Leu Leu Pro Leu Ser 
        755                 760                 765             


His Leu Val Met Tyr Met Glu Asn Phe Ile Glu His Leu Gly Arg Phe 
    770                 775                 780                 


Pro Ala His Ile Leu Asp Cys Leu Ser Gly Ile Tyr Tyr Arg Leu Pro 
785                 790                 795                 800 


Gly Leu Glu Gln Val Leu Asn Thr Gln Asp Val Gln Asp Val Gln Asn 
                805                 810                 815     


Val Gln Asn Ile Leu Glu Met Leu Leu Arg Leu Leu Asp Thr Tyr Arg 
            820                 825                 830         


Asp Lys Ile Pro Glu Glu Ala Leu Ser Pro Ser Tyr Leu Thr Val Cys 
        835                 840                 845             


Leu Lys Leu His Glu Ala Ile Cys Ser Ser Thr Lys Leu Leu Lys Phe 
    850                 855                 860                 


Tyr Glu Leu Pro Ala Leu Ser Ala Glu Ile Val Cys Arg Met Ile Arg 
865                 870                 875                 880 


Leu Leu Ser Leu Val Asp Ser Ala Gly Gln Arg Asp Glu Thr Gly Asn 
                885                 890                 895     


Asn Ser Val Gln Thr Val Phe Gln Gly Thr Leu Ala Ala Thr Lys Arg 
            900                 905                 910         


Trp Leu Arg Glu Val Phe Thr Lys Asn Met Leu Thr Ser Ser Gly Ala 
        915                 920                 925             


Ser Phe Thr Tyr Val Lys Glu Ile Glu Val Trp Arg Arg Leu Val Glu 
    930                 935                 940                 


Ile Gln Phe Pro Ala Glu His Gly Trp Lys Glu Ser Leu Leu Gly Asp 
945                 950                 955                 960 


Met Glu Trp Arg Leu Thr Lys Glu Glu Pro Leu Ser Gln Ile Thr Ala 
                965                 970                 975     


Tyr Cys Asn Ser Cys Trp Asp Thr Lys Gly Leu Glu Asp Ser Val Ala 
            980                 985                 990         


Lys Thr Phe Glu Lys Cys Ile Ile  Glu Ala Val Ser Ser  Ala Cys Gln 
        995                 1000                 1005             


Ser Gln  Thr Ser Ile Leu Gln  Gly Phe Ser Tyr Ser  Asp Leu Arg 
    1010                 1015                 1020             


Lys Phe  Gly Ile Val Leu Ser  Ala Val Ile Thr Lys  Ser Trp Pro 
    1025                 1030                 1035             


Arg Thr  Ala Asp Asn Phe Asp  Asp Ile Leu Lys His  Leu Leu Thr 
    1040                 1045                 1050             


Leu Ala  Asp Val Lys His Val  Phe Arg Leu Cys Gly  Thr Asp Glu 
    1055                 1060                 1065             


Lys Ile  Leu Ala Asn Val Thr  Glu Asp Ala Lys Arg  Leu Ile Ala 
    1070                 1075                 1080             


Val Ala  Asp Ser Val Leu Thr  Lys Val Val Gly Asp  Leu Leu Ser 
    1085                 1090                 1095             


Gly Thr  Ile Leu Val Gly Gln  Leu Glu Leu Ile Ile  Lys His Lys 
    1100                 1105                 1110             


Asn Gln  Phe Leu Asp Ile Trp  Gln Leu Arg Glu Lys  Ser Leu Ser 
    1115                 1120                 1125             


Pro Gln  Asp Glu Lys Cys Ala  Val Glu Glu Ala Leu  Asp Trp Arg 
    1130                 1135                 1140             


Arg Glu  Glu Leu Leu Leu Leu  Lys Lys Glu Lys Arg  Cys Val Asp 
    1145                 1150                 1155             


Ser Leu  Leu Lys Met Cys Gly  Asn Val Lys His Leu  Ile Gln Val 
    1160                 1165                 1170             


Asp Phe  Gly Val Leu Ala Val  Arg His Ser Gln Asp  Leu Ser Ser 
    1175                 1180                 1185             


Lys Arg  Leu Asn Asp Thr Met  Thr Val Arg Leu Ser  Thr Ser Ser 
    1190                 1195                 1200             


Asn Ser  Gln Arg Ala Thr His  Tyr His Leu Ser Ser  Gln Val Gln 
    1205                 1210                 1215             


Glu Met  Ala Gly Lys Ile Asp  Leu Leu Arg Asp Ser  His Ile Phe 
    1220                 1225                 1230             


Gln Leu  Phe Trp Arg Glu Ala  Ala Glu Pro Leu Ser  Glu Pro Lys 
    1235                 1240                 1245             


Glu Asp  Gln Glu Ala Ala Glu  Leu Leu Ser Glu Pro  Glu Glu Glu 
    1250                 1255                 1260             


Ser Glu  Arg His Ile Leu Glu  Leu Gln Glu Val Tyr  Asp Tyr Leu 
    1265                 1270                 1275             


Tyr Gln  Pro Ser Tyr Arg Lys  Phe Ile Lys Leu His  Gln Asp Leu 
    1280                 1285                 1290             


Lys Ser  Gly Glu Val Thr Leu  Ala Glu Ile Asp Val  Ile Phe Lys 
    1295                 1300                 1305             


Asp Phe  Val Asn Lys Tyr Thr  Asp Leu Asp Ser Glu  Leu Lys Ile 
    1310                 1315                 1320             


Met Cys  Thr Val Asp His Gln  Gly Gln Arg Asp Trp  Ile Lys Asp 
    1325                 1330                 1335             


Arg Val  Glu Gln Ile Lys Glu  Tyr His His Leu His  Gln Ala Val 
    1340                 1345                 1350             


His Ala  Ala Lys Val Ile Leu  Gln Val Lys Glu Ser  Leu Gly Leu 
    1355                 1360                 1365             


Asn Gly  Asp Phe Ser Val Leu  Asn Thr Leu Leu Asn  Phe Thr Asp 
    1370                 1375                 1380             


Asn Phe  Asp Asp Phe Arg Arg  Glu Thr Leu Asp Gln  Ile Asn Gln 
    1385                 1390                 1395             


Glu Leu  Ile Gln Ala Lys Lys  Leu Leu Gln Asp Ile  Ser Glu Ala 
    1400                 1405                 1410             


Arg Cys  Lys Gly Leu Gln Ala  Leu Ser Leu Arg Lys  Glu Phe Ile 
    1415                 1420                 1425             


Cys Trp  Val Arg Glu Ala Leu  Gly Gly Ile Asn Glu  Leu Lys Val 
    1430                 1435                 1440             


Phe Val  Asp Leu Ala Ser Ile  Ser Ala Gly Glu Asn  Asp Ile Asp 
    1445                 1450                 1455             


Val Asp  Arg Val Ala Cys Phe  His Asp Ala Val Gln  Gly Tyr Ala 
    1460                 1465                 1470             


Ser Leu  Leu Phe Lys Leu Asp  Pro Ser Val Asp Phe  Ser Ala Phe 
    1475                 1480                 1485             


Met Lys  His Leu Lys Lys Leu  Trp Lys Ala Leu Asp  Lys Asp Gln 
    1490                 1495                 1500             


Tyr Leu  Pro Arg Lys Leu Val  Ser Leu Ile Leu Ser  Leu Met Gln 
    1505                 1510                 1515             


Ile Leu  Leu Asn Arg Ala Leu  Leu Ser Asn Val Arg  Ala Val Thr 
    1520                 1525                 1530             


Val Glu  Met Val Ala His Leu  Cys Gly Arg Phe Val  His Ser Arg 
    1535                 1540                 1545             


Phe Gln  
    1550 


<210>  38
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Val Ala Ala Lys Lys Thr Lys Lys Ser Leu Glu Ser Ile Asn Ser 
1               5                   10                  15      


Arg Leu Gln Leu Val Met Lys Ser Gly Lys Tyr Val Leu Gly Tyr Lys 
            20                  25                  30          


Gln Thr Leu Lys Met Ile Arg Gln Gly Lys Ala Lys Leu Val Ile Leu 
        35                  40                  45              


Ala Asn Asn Cys Pro Ala Leu Arg Lys Ser Glu Ile Glu Tyr Tyr Ala 
    50                  55                  60                  


Met Leu Ala Lys Thr Gly Val His His Tyr Ser Gly Asn Asn Ile Glu 
65                  70                  75                  80  


Leu Gly Thr Ala Cys Gly Lys Tyr Tyr Arg Val Cys Thr Leu Ala Ile 
                85                  90                  95      


Ile Asp Pro Gly Asp Ser Asp Ile Ile Arg Ser Met Pro Glu Gln Thr 
            100                 105                 110         


Gly Glu Lys 
        115 


<210>  39
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Val Leu Leu Thr Met Ile Ala Arg Val Ala Asp Gly Leu Pro Leu 
1               5                   10                  15      


Ala Ala Ser Met Gln Glu Asp Glu Gln Ser Gly Arg Asp Leu Gln Gln 
            20                  25                  30          


Tyr Gln Ser Gln Ala Lys Gln Leu Phe Arg Lys Leu Asn Glu Gln Ser 
        35                  40                  45              


Pro Thr Arg Cys Thr Leu Glu Ala Gly Ala Met Thr Phe His Tyr Ile 
    50                  55                  60                  


Ile Glu Gln Gly Val Cys Tyr Leu Val Leu Cys Glu Ala Ala Phe Pro 
65                  70                  75                  80  


Lys Lys Leu Ala Phe Ala Tyr Leu Glu Asp Leu His Ser Glu Phe Asp 
                85                  90                  95      


Glu Gln His Gly Lys Lys Val Pro Thr Val Ser Arg Pro Tyr Ser Phe 
            100                 105                 110         


Ile Glu Phe Asp Thr Phe Ile Gln Lys Thr Lys Lys Leu Tyr Ile Asp 
        115                 120                 125             


Ser Arg Ala Arg Arg Asn Leu Gly Ser Ile Asn Thr Glu Leu Gln Asp 
    130                 135                 140                 


Val Gln Arg Ile Met Val Ala Asn Ile Glu Glu Val Leu Gln Arg Gly 
145                 150                 155                 160 


Glu Ala Leu Ser Ala Leu Asp Ser Lys Ala Asn Asn Leu Ser Ser Leu 
                165                 170                 175     


Ser Lys Lys Tyr Arg Gln Asp Ala Lys Tyr Leu Asn Met Arg Ser Thr 
            180                 185                 190         


Tyr Ala Lys Leu Ala Ala Val Ala Val Phe Phe Ile Met Leu Ile Val 
        195                 200                 205             


Tyr Val Arg Phe Trp Trp Leu 
    210                 215 


<210>  40
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Asp Arg Ile Ser 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Val Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Val Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Glu Asp Phe Gly Glu Glu Ala Glu Glu Glu Ala 
        435                 440                 


<210>  41
<211>  1416
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Lys Ser Leu Lys Ser Arg Leu Arg Arg Gln Asp Val Pro Gly Pro 
1               5                   10                  15      


Ala Ser Ser Gly Ala Ala Ala Ala Ser Ala His Ala Ala Asp Trp Asn 
            20                  25                  30          


Lys Tyr Asp Asp Arg Leu Met Lys Ala Ala Glu Arg Gly Asp Val Glu 
        35                  40                  45              


Lys Val Thr Ser Ile Leu Ala Lys Lys Gly Val Asn Pro Gly Lys Leu 
    50                  55                  60                  


Asp Val Glu Gly Arg Ser Val Phe His Val Val Thr Ser Lys Gly Asn 
65                  70                  75                  80  


Leu Glu Cys Leu Asn Ala Ile Leu Ile His Gly Val Asp Ile Thr Thr 
                85                  90                  95      


Ser Asp Thr Ala Gly Arg Asn Ala Leu His Leu Ala Ala Lys Tyr Gly 
            100                 105                 110         


His Ala Leu Cys Leu Gln Lys Leu Leu Gln Tyr Asn Cys Pro Thr Glu 
        115                 120                 125             


His Ala Asp Leu Gln Gly Arg Thr Ala Leu His Asp Ala Ala Met Ala 
    130                 135                 140                 


Asp Cys Pro Ser Ser Ile Gln Leu Leu Cys Asp His Gly Ala Ser Val 
145                 150                 155                 160 


Asn Ala Lys Asp Val Asp Gly Arg Thr Pro Leu Val Leu Ala Thr Gln 
                165                 170                 175     


Met Ser Arg Pro Thr Ile Cys Gln Leu Leu Ile Asp Arg Gly Ala Asp 
            180                 185                 190         


Val Asn Ser Arg Asp Lys Gln Asn Arg Thr Ala Leu Met Leu Gly Cys 
        195                 200                 205             


Glu Tyr Gly Cys Arg Asp Ala Val Glu Val Leu Ile Lys Asn Gly Ala 
    210                 215                 220                 


Asp Ile Ser Leu Leu Asp Ala Leu Gly His Asp Ser Ser Tyr Tyr Ala 
225                 230                 235                 240 


Arg Ile Gly Asp Asn Leu Asp Ile Leu Thr Leu Leu Lys Thr Ala Ser 
                245                 250                 255     


Glu Asn Thr Asn Lys Gly Arg Glu Leu Trp Lys Lys Gly Pro Ser Leu 
            260                 265                 270         


Gln Gln Arg Asn Leu Thr His Met Gln Asp Glu Val Asn Val Lys Ser 
        275                 280                 285             


His Gln Arg Glu His Gln Asn Ile Gln Asp Leu Glu Ile Glu Asn Glu 
    290                 295                 300                 


Asp Leu Lys Glu Arg Leu Arg Lys Ile Gln Gln Glu Gln Arg Ile Leu 
305                 310                 315                 320 


Leu Asp Lys Val Asn Gly Leu Gln Leu Gln Leu Asn Glu Glu Val Met 
                325                 330                 335     


Val Ala Asp Asp Leu Glu Ser Glu Arg Glu Lys Leu Lys Ser Leu Leu 
            340                 345                 350         


Ala Ala Lys Glu Lys Gln His Glu Glu Ser Leu Arg Thr Ile Glu Ala 
        355                 360                 365             


Leu Lys Asn Arg Phe Lys Tyr Phe Glu Ser Asp His Leu Gly Ser Gly 
    370                 375                 380                 


Ser His Phe Ser Asn Arg Lys Glu Asp Met Leu Leu Lys Gln Gly Gln 
385                 390                 395                 400 


Met Tyr Met Ala Asp Ser Gln Cys Thr Ser Pro Gly Ile Pro Ala His 
                405                 410                 415     


Met Gln Ser Arg Ser Met Leu Arg Pro Leu Glu Leu Ser Leu Pro Ser 
            420                 425                 430         


Gln Thr Ser Tyr Ser Glu Asn Glu Ile Leu Lys Lys Glu Leu Glu Ala 
        435                 440                 445             


Met Arg Thr Phe Cys Glu Ser Ala Lys Gln Asp Arg Leu Lys Leu Gln 
    450                 455                 460                 


Asn Glu Leu Ala His Lys Val Ala Glu Cys Lys Ala Leu Ala Leu Glu 
465                 470                 475                 480 


Cys Glu Arg Val Lys Glu Asp Ser Asp Glu Gln Ile Lys Gln Leu Glu 
                485                 490                 495     


Asp Ala Leu Lys Asp Val Gln Lys Arg Met Tyr Glu Ser Glu Gly Lys 
            500                 505                 510         


Val Lys Gln Met Gln Thr His Phe Leu Ala Leu Lys Glu His Leu Thr 
        515                 520                 525             


Ser Glu Ala Ala Ser Gly Asn His Arg Leu Thr Glu Glu Leu Lys Asp 
    530                 535                 540                 


Gln Leu Lys Asp Leu Lys Val Lys Tyr Glu Gly Ala Ser Ala Glu Val 
545                 550                 555                 560 


Gly Lys Leu Arg Asn Gln Ile Lys Gln Asn Glu Met Ile Val Glu Glu 
                565                 570                 575     


Phe Lys Arg Asp Glu Gly Lys Leu Ile Glu Glu Asn Lys Arg Leu Gln 
            580                 585                 590         


Lys Glu Leu Ser Met Cys Glu Met Glu Arg Glu Lys Lys Gly Arg Lys 
        595                 600                 605             


Val Thr Glu Met Glu Gly Gln Ala Lys Glu Leu Ser Ala Lys Leu Ala 
    610                 615                 620                 


Leu Ser Ile Pro Ala Glu Lys Phe Glu Asn Met Lys Ser Ser Leu Ser 
625                 630                 635                 640 


Asn Glu Val Asn Glu Lys Ala Lys Lys Leu Val Glu Met Glu Arg Glu 
                645                 650                 655     


His Glu Lys Ser Leu Ser Glu Ile Arg Gln Leu Lys Arg Glu Leu Glu 
            660                 665                 670         


Asn Val Lys Ala Lys Leu Ala Gln His Val Lys Pro Glu Glu His Glu 
        675                 680                 685             


Gln Val Lys Ser Arg Leu Glu Gln Lys Ser Gly Glu Leu Gly Lys Lys 
    690                 695                 700                 


Ile Thr Glu Leu Thr Leu Lys Asn Gln Thr Leu Gln Lys Glu Ile Glu 
705                 710                 715                 720 


Lys Val Tyr Leu Asp Asn Lys Leu Leu Lys Glu Gln Ala His Asn Leu 
                725                 730                 735     


Thr Ile Glu Met Lys Asn His Tyr Val Pro Leu Lys Val Ser Glu Asp 
            740                 745                 750         


Met Lys Lys Ser His Asp Ala Ile Ile Asp Asp Leu Asn Arg Lys Leu 
        755                 760                 765             


Leu Asp Val Thr Gln Lys Tyr Thr Glu Lys Lys Leu Glu Met Glu Lys 
    770                 775                 780                 


Leu Leu Leu Glu Asn Asp Ser Leu Ser Lys Asp Val Ser Arg Leu Glu 
785                 790                 795                 800 


Thr Val Phe Val Pro Pro Glu Lys His Glu Lys Glu Ile Ile Ala Leu 
                805                 810                 815     


Lys Ser Asn Ile Val Glu Leu Lys Lys Gln Leu Ser Glu Leu Lys Lys 
            820                 825                 830         


Lys Cys Gly Glu Asp Gln Glu Lys Ile His Ala Leu Thr Ser Glu Asn 
        835                 840                 845             


Thr Asn Leu Lys Lys Met Met Ser Asn Gln Tyr Val Pro Val Lys Thr 
    850                 855                 860                 


His Glu Glu Val Lys Met Thr Leu Asn Asp Thr Leu Ala Lys Thr Asn 
865                 870                 875                 880 


Arg Glu Leu Leu Asp Val Lys Lys Lys Phe Glu Asp Ile Asn Gln Glu 
                885                 890                 895     


Phe Val Lys Ile Lys Asp Lys Asn Glu Ile Leu Lys Arg Asn Leu Glu 
            900                 905                 910         


Asn Thr Gln Asn Gln Ile Lys Ala Glu Tyr Ile Ser Leu Ala Glu His 
        915                 920                 925             


Glu Ala Lys Met Ser Ser Leu Ser Gln Ser Met Arg Lys Val Gln Asp 
    930                 935                 940                 


Ser Asn Ala Glu Ile Leu Ala Asn Tyr Arg Lys Gly Gln Glu Glu Ile 
945                 950                 955                 960 


Val Thr Leu His Ala Glu Ile Lys Ala Gln Lys Lys Glu Leu Asp Thr 
                965                 970                 975     


Ile Gln Glu Cys Ile Lys Val Lys Tyr Ala Pro Ile Val Ser Phe Glu 
            980                 985                 990         


Glu Cys Glu Arg Lys Phe Lys Ala  Thr Glu Lys Glu Leu  Lys Asp Gln 
        995                 1000                 1005             


Leu Ser  Glu Gln Thr Gln Lys  Tyr Ser Val Ser Glu  Glu Glu Val 
    1010                 1015                 1020             


Lys Lys  Asn Lys Gln Glu Asn  Asp Lys Leu Lys Lys  Glu Ile Phe 
    1025                 1030                 1035             


Thr Leu  Gln Lys Asp Leu Arg  Asp Lys Thr Val Leu  Ile Glu Lys 
    1040                 1045                 1050             


Ser His  Glu Met Glu Arg Ala  Leu Ser Arg Lys Thr  Asp Glu Leu 
    1055                 1060                 1065             


Asn Lys  Gln Leu Lys Asp Leu  Ser Gln Lys Tyr Thr  Glu Val Lys 
    1070                 1075                 1080             


Asn Val  Lys Glu Lys Leu Val  Glu Glu Asn Ala Lys  Gln Thr Ser 
    1085                 1090                 1095             


Glu Ile  Leu Ala Val Gln Asn  Leu Leu Gln Lys Gln  His Val Pro 
    1100                 1105                 1110             


Leu Glu  Gln Val Glu Ala Leu  Lys Lys Ser Leu Asn  Gly Thr Ile 
    1115                 1120                 1125             


Glu Asn  Leu Lys Glu Glu Leu  Lys Ser Met Gln Arg  Cys Tyr Glu 
    1130                 1135                 1140             


Lys Glu  Gln Gln Thr Val Thr  Lys Leu His Gln Leu  Leu Glu Asn 
    1145                 1150                 1155             


Gln Lys  Asn Ser Ser Val Pro  Leu Ala Glu His Leu  Gln Ile Lys 
    1160                 1165                 1170             


Glu Ala  Phe Glu Lys Glu Val  Gly Ile Ile Lys Ala  Ser Leu Arg 
    1175                 1180                 1185             


Glu Lys  Glu Glu Glu Ser Gln  Asn Lys Met Glu Glu  Val Ser Lys 
    1190                 1195                 1200             


Leu Gln  Ser Glu Val Gln Asn  Thr Lys Gln Ala Leu  Lys Lys Leu 
    1205                 1210                 1215             


Glu Thr  Arg Glu Val Val Asp  Leu Ser Lys Tyr Lys  Ala Thr Lys 
    1220                 1225                 1230             


Ser Asp  Leu Glu Thr Gln Ile  Ser Ser Leu Asn Glu  Lys Leu Ala 
    1235                 1240                 1245             


Asn Leu  Asn Arg Lys Tyr Glu  Glu Val Cys Glu Glu  Val Leu His 
    1250                 1255                 1260             


Ala Lys  Lys Lys Glu Ile Ser  Ala Lys Asp Glu Lys  Glu Leu Leu 
    1265                 1270                 1275             


His Phe  Ser Ile Glu Gln Glu  Ile Lys Asp Gln Lys  Glu Arg Cys 
    1280                 1285                 1290             


Asp Lys  Ser Leu Thr Thr Ile  Thr Glu Leu Gln Arg  Arg Ile Gln 
    1295                 1300                 1305             


Glu Ser  Ala Lys Gln Ile Glu  Ala Lys Asp Asn Lys  Ile Thr Glu 
    1310                 1315                 1320             


Leu Leu  Asn Asp Val Glu Arg  Leu Lys Gln Ala Leu  Asn Gly Leu 
    1325                 1330                 1335             


Ser Gln  Leu Thr Tyr Thr Ser  Gly Asn Pro Thr Lys  Arg Gln Ser 
    1340                 1345                 1350             


Gln Leu  Ile Asp Thr Leu Gln  His Gln Val Lys Ser  Leu Glu Gln 
    1355                 1360                 1365             


Gln Leu  Ala Asp Ala Asp Arg  Gln His Gln Glu Val  Ile Ala Ile 
    1370                 1375                 1380             


Tyr Arg  Thr His Leu Leu Ser  Ala Ala Gln Gly His  Met Asp Glu 
    1385                 1390                 1395             


Asp Val  Gln Glu Ala Leu Leu  Gln Ile Ile Gln Met  Arg Gln Gly 
    1400                 1405                 1410             


Leu Val  Cys 
    1415     


