                         SEQUENCE LISTING

<110>  ASEA, ALEXZANDER
       ROSA, PAOLA
 
<120>  THERAPEUTIC EFFECT OF HEAT SHOCK PROTEINS IN PREVENTING AMYLIN 
       AGGREGATION IN TYPE 2 DIABETES MELLITUS

<130>  SCOT.P0016WO

<140>  UNKNOWN
<141>  2012-01-13

<150>  61/432793
<151>  2011-01-14

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  2
<211>  2445
<212>  DNA
<213>  Homo sapiens

<400>  2
ataaaagccc aggggcaagc ggtccggata acggctagcc tgaggagctg ctgcgacagt       60

ccactacctt tttcgagagt gactcccgtt gtcccaaggc ttcccagagc gaacctgtgc      120

ggctgcaggc accggcgcgt cgagtttccg gcgtccggaa ggaccgagct cttctcgcgg      180

atccagtgtt ccgtttccag cccccaatct cagagcggag ccgacagaga gcagggaacc      240

ggcatggcca aagccgcggc gatcggcatc gacctgggca ccacctactc ctgcgtgggg      300

gtgttccaac acggcaaggt ggagatcatc gccaacgacc agggcaaccg caccaccccc      360

agctacgtgg ccttcacgga caccgagcgg ctcatcgggg atgcggccaa gaaccaggtg      420

gcgctgaacc cgcagaacac cgtgtttgac gcgaagcggc tgattggccg caagttcggc      480

gacccggtgg tgcagtcgga catgaagcac tggcctttcc aggtgatcaa cgacggagac      540

aagcccaagg tgcaggtgag ctacaagggg gagaccaagg cattctaccc cgaggagatc      600

tcgtccatgg tgctgaccaa gatgaaggag atcgccgagg cgtacctggg ctacccggtg      660

accaacgcgg tgatcaccgt gccggcctac ttcaacgact cgcagcgcca ggccaccaag      720

gatgcgggtg tgatcgcggg gctcaacgtg ctgcggatca tcaacgagcc cacggccgcc      780

gccatcgcct acggcctgga cagaacgggc aagggggagc gcaacgtgct catctttgac      840

ctgggcgggg gcaccttcga cgtgtccatc ctgacgatcg acgacggcat cttcgaggtg      900

aaggccacgg ccggggacac ccacctgggt ggggaggact ttgacaacag gctggtgaac      960

cacttcgtgg aggagttcaa gagaaaacac aagaaggaca tcagccagaa caagcgagcc     1020

gtgaggcggc tgcgcaccgc ctgcgagagg gccaagagga ccctgtcgtc cagcacccag     1080

gccagcctgg agatcgactc cctgtttgag ggcatcgact tctacacgtc catcaccagg     1140

gcgaggttcg aggagctgtg ctccgacctg ttccgaagca ccctggagcc cgtggagaag     1200

gctctgcgcg acgccaagct ggacaaggcc cagattcacg acctggtcct ggtcgggggc     1260

tccacccgca tccccaaggt gcagaagctg ctgcaggact tcttcaacgg gcgcgacctg     1320

aacaagagca tcaaccccga cgaggctgtg gcctacgggg cggcggtgca ggcggccatc     1380

ctgatggggg acaagtccga gaacgtgcag gacctgctgc tgctggacgt ggctcccctg     1440

tcgctggggc tggagacggc cggaggcgtg atgactgccc tgatcaagcg caactccacc     1500

atccccacca agcagacgca gatcttcacc acctactccg acaaccaacc cggggtgctg     1560

atccaggtgt acgagggcga gagggccatg acgaaagaca acaatctgtt ggggcgcttc     1620

gagctgagcg gcatccctcc ggcccccagg ggcgtgcccc agatcgaggt gaccttcgac     1680

atcgatgcca acggcatcct gaacgtcacg gccacggaca agagcaccgg caaggccaac     1740

aagatcacca tcaccaacga caagggccgc ctgagcaagg aggagatcga gcgcatggtg     1800

caggaggcgg agaagtacaa agcggaggac gaggtgcagc gcgagagggt gtcagccaag     1860

aacgccctgg agtcctacgc cttcaacatg aagagcgccg tggaggatga ggggctcaag     1920

ggcaagatca gcgaggcgga caagaagaag gtgctggaca agtgtcaaga ggtcatctcg     1980

tggctggacg ccaacacctt ggccgagaag gacgagtttg agcacaagag gaaggagctg     2040

gagcaggtgt gtaaccccat catcagcgga ctgtaccagg gtgccggtgg tcccgggcct     2100

gggggcttcg gggctcaggg tcccaaggga gggtctgggt caggccccac cattgaggag     2160

gtagattagg ggcctttcca agattgctgt ttttgttttg gagcttcaag actttgcatt     2220

tcctagtatt tctgtttgtc agttctcaat ttcctgtgtt tgcaatgttg aaattttttg     2280

gtgaagtact gaacttgctt tttttccggt ttctacatgc agagatgaat ttatactgcc     2340

atcttacgac tatttcttct ttttaataca cttaactcag gccatttttt aagttggtta     2400

cttcaaagta aataaacttt aaaattcaaa aaaaaaaaaa aaaaa                     2445


<210>  3
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp 
1               5                   10                  15      


Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala 
            20                  25                  30          


Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly 
        35                  40                  45              


Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu 
    50                  55                  60                  


Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln 
65                  70                  75                  80  


Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg 
                85                  90                  95      


Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys 
            100                 105                 110         


Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys His Glu Glu Arg Gln 
        115                 120                 125             


Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu 
    130                 135                 140                 


Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu 
145                 150                 155                 160 


Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser 
                165                 170                 175     


Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly 
            180                 185                 190         


Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala Lys 
        195                 200                 205 


<210>  4
<211>  914
<212>  DNA
<213>  Homo sapiens

<400>  4
gcatggggag gggcggccct caaacgggtc attgccatta atagagacct caaacaccgc       60

ctgctaaaaa tacccgactg gaggagcata aaagcgcagc cgagcccagc gccccgcact      120

tttctgagca gacgtccaga gcagagtcag ccagcatgac cgagcgccgc gtccccttct      180

cgctcctgcg gggccccagc tgggacccct tccgcgactg gtacccgcat agccgcctct      240

tcgaccaggc cttcgggctg ccccggctgc cggaggagtg gtcgcagtgg ttaggcggca      300

gcagctggcc aggctacgtg cgccccctgc cccccgccgc catcgagagc cccgcagtgg      360

ccgcgcccgc ctacagccgc gcgctcagcc ggcaactcag cagcggggtc tcggagatcc      420

ggcacactgc ggaccgctgg cgcgtgtccc tggatgtcaa ccacttcgcc ccggacgagc      480

tgacggtcaa gaccaaggat ggcgtggtgg agatcaccgg caagcacgag gagcggcagg      540

acgagcatgg ctacatctcc cggtgcttca cgcggaaata cacgctgccc cccggtgtgg      600

accccaccca agtttcctcc tccctgtccc ctgagggcac actgaccgtg gaggccccca      660

tgcccaagct agccacgcag tccaacgaga tcaccatccc agtcaccttc gagtcgcggg      720

cccagcttgg gggcccagaa gctgcaaaat ccgatgagac tgccgccaag taaagcctta      780

gcccggatgc ccacccctgc tgccgccact ggctgtgcct cccccgccac ctgtgtgttc      840

ttttgataca tttatcttct gtttttctca aataaagttc aaagcaacca cctgtcaaaa      900

aaaaaaaaaa aaaa                                                        914


<210>  5
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
1               5                   10                  15      


Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
            20                  25                  30          


Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
        35                  40                  45              


Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
    50                  55                  60                  


Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
65                  70                  75                  80  


Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                85                  90                  95      


Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
            100                 105                 110         


Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
        115                 120                 125             


Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
    130                 135                 140                 


Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
145                 150                 155                 160 


Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                165                 170                 175     


Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
            180                 185                 190         


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
        195                 200                 205             


Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
    210                 215                 220                 


Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
225                 230                 235                 240 


Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                245                 250                 255     


Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
            260                 265                 270         


Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
        275                 280                 285             


Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
    290                 295                 300                 


Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
305                 310                 315                 320 


Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                325                 330                 335     


Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
            340                 345                 350         


Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
        355                 360                 365             


Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
    370                 375                 380                 


Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
385                 390                 395                 400 


Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                405                 410                 415     


Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
            420                 425                 430         


Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
        435                 440                 445             


Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
    450                 455                 460                 


Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
465                 470                 475                 480 


Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                485                 490                 495     


Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
            500                 505                 510         


Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
        515                 520                 525             


Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
    530                 535                 540                 


Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
545                 550                 555                 560 


Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                565                 570                 575     


Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
            580                 585                 590         


Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
        595                 600                 605             


Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
    610                 615                 620                 


Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
625                 630                 635                 640 


Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                645                 650                 655     


Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
            660                 665                 670         


Asp Gln Lys Glu Glu Lys Gln 
        675                 


<210>  6
<211>  2850
<212>  DNA
<213>  Homo sapiens

<400>  6
tcaccccacg tggttggagg tttccagaag cgctgccgcc accgcatcgc gcagctcttt       60

gccgtcggag cgcttgtttg ctgcctcgta ctcctccatt tatccgccat gataagtgcc      120

agccgagctg cagcagcccg tctcgtgggc gccgcagcct cccggggccc tacggccgcc      180

cgccaccagg atagctggaa tggccttagt catgaggctt ttagacttgt ttcaaggcgg      240

gattatgcat cagaagcaat caagggagca gttgttggta ttgatttggg tactaccaac      300

tcctgcgtgg cagttatgga aggtaaacaa gcaaaggtgc tggagaatgc cgaaggtgcc      360

agaaccaccc cttcagttgt ggcctttaca gcagatggtg agcgacttgt tggaatgccg      420

gccaagcgac aggctgtcac caacccaaac aatacatttt atgctaccaa gcgtctcatt      480

ggccggcgat atgatgatcc tgaagtacag aaagacatta aaaatgttcc ctttaaaatt      540

gtccgtgcct ccaatggtga tgcctgggtt gaggctcatg ggaaattgta ttctccgagt      600

cagattggag catttgtgtt gatgaagatg aaagagactg cagaaaatta cttggggcac      660

acagcaaaaa atgctgtgat cacagtccca gcttatttca atgactcgca gagacaggcc      720

actaaagatg ctggccagat atctggactg aatgtgcttc gggtgattaa tgagcccaca      780

gctgctgctc ttgcctatgg tctagacaaa tcagaagaca aagtcattgc tgtatatgat      840

ttaggtggtg gaacttttga tatttctatc ctggaaattc agaaaggagt atttgaggtg      900

aaatccacaa atggggatac cttcttaggt ggggaagact ttgaccaggc cttgctacgg      960

cacattgtga aggagttcaa gagagagaca ggggttgatt tgactaaaga caacatggca     1020

cttcagaggg tacgggaagc tgctgaaaag gctaaatgtg aactctcctc atctgtgcag     1080

actgacatca atttgcccta tcttacaatg gattcttctg gacccaagca tttgaatatg     1140

aagttgaccc gtgctcaatt tgaagggatt gtcactgatc taatcagaag gactatcgct     1200

ccatgccaaa aagctatgca agatgcagaa gtcagcaaga gtgacatagg agaagtgatt     1260

cttgtgggtg gcatgactag gatgcccaag gttcagcaga ctgtacagga tctttttggc     1320

agagccccaa gtaaagctgt caatcctgat gaggctgtgg ccattggagc tgccattcag     1380

ggaggtgtgt tggccggcga tgtcacggat gtgctgctcc ttgatgtcac tcccctgtct     1440

ctgggtattg aaactctagg aggtgtcttt accaaactta ttaataggaa taccactatt     1500

ccaaccaaga agagccaggt attctctact gccgctgatg gtcaaacgca agtggaaatt     1560

aaagtgtgtc agggtgaaag agagatggct ggagacaaca aactccttgg acagtttact     1620

ttgattggaa ttccaccagc ccctcgtgga gttcctcaga ttgaagttac atttgacatt     1680

gatgccaatg ggatagtaca tgtttctgct aaagataaag gcacaggacg tgagcagcag     1740

attgtaatcc agtcttctgg tggattaagc aaagatgata ttgaaaatat ggttaaaaat     1800

gcagagaaat atgctgaaga agaccggcga aagaaggaac gagttgaagc agttaatatg     1860

gctgaaggaa tcattcacga cacagaaacc aagatggaag aattcaagga ccaattacct     1920

gctgatgagt gcaacaagct gaaagaagag atttccaaaa tgagggagct cctggctaga     1980

aaagacagcg aaacaggaga aaatattaga caggcagcat cctctcttca gcaggcatca     2040

ctgaagctgt tcgaaatggc atacaaaaag atggcatctg agcgagaagg ctctggaagt     2100

tctggcactg gggaacaaaa ggaagatcaa aaggaggaaa aacagtaata atagcagaaa     2160

ttttgaagcc agaaggacaa catatgaagc ttaggagtga agagacttcc tgagcagaaa     2220

tgggcgaact tcagtctttt tactgtgttt ttgcagtatt ctatatataa tttccttaat     2280

ttgtaaattt agtgaccatt agctagtgat catttaatgg acagtgattc taacagtata     2340

aagttcacaa tattctatgt ccctagcctg tcatttttca gctgcatgta aaaggaggta     2400

ggatgaattg atcattataa agatttaact attttatgct gaagtgacca tattttcaag     2460

gggtgaaacc atctcgcaca cagcaatgaa ggtagtcatc catagacttg aaatgagacc     2520

acatatgggg atgagatcct tctagttagc ctagtactgc tgtactggcc tgtatgtaca     2580

tggggtcctt caactgaggc cttgcaagtc aagctggctg tgccatgttt gtagatgggg     2640

cagaggaatc tagaacaatg ggaaacttag ctatttatat taggtacagc tattaaaaca     2700

aggtaggaat gaggctagac ctttaacttc cctaaggcat acttttctag ctaccttctg     2760

ccctgtgtct ggcacctaca tccttgatga ttgttctctt acccattctg gaattttttt     2820

ttttttaaat aaatacagaa agcatcttga                                      2850


<210>  7
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly 
            20                  25                  30          


Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly 
        35                  40                  45              


Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser 
    50                  55                  60                  


Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala 
65                  70                  75                  80  


Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys 
                85                  90                  95      


Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile 
            100                 105                 110         


Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile 
        115                 120                 125             


Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu 
    130                 135                 140                 


Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr 
145                 150                 155                 160 


Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe 
                165                 170                 175     


Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly 
            180                 185                 190         


Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala 
        195                 200                 205             


Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp 
    210                 215                 220                 


Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly 
225                 230                 235                 240 


Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu 
                245                 250                 255     


Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys 
            260                 265                 270         


Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu 
        275                 280                 285             


Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln 
    290                 295                 300                 


Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu 
305                 310                 315                 320 


Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg 
                325                 330                 335     


Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys 
            340                 345                 350         


Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile 
        355                 360                 365             


Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro 
    370                 375                 380                 


Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu 
                405                 410                 415     


Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val 
            420                 425                 430         


Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser 
        435                 440                 445             


Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys 
    450                 455                 460                 


Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly 
465                 470                 475                 480 


Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln 
                485                 490                 495     


Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr 
            500                 505                 510         


Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn 
        515                 520                 525             


Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp 
    530                 535                 540                 


Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp 
545                 550                 555                 560 


Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile 
                565                 570                 575     


Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu 
            580                 585                 590         


Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His 
        595                 600                 605             


Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu 
    610                 615                 620                 


Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro 
625                 630                 635                 640 


Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
                645                 650                 


<210>  8
<211>  3965
<212>  DNA
<213>  Homo sapiens

<400>  8
gggggagggt atataagccg agtaggcgac ggtgaggtcg acgccggcca agacagcaca       60

gacagattga cctattgggg tgtttcgcga gtgtgagagg gaagcgccgc ggcctgtatt      120

tctagacctg cccttcgcct ggttcgtggc gccttgtgac cccgggcccc tgccgcctgc      180

aagtcggaaa ttgcgctgtg ctcctgtgct acggcctgtg gctggactgc ctgctgctgc      240

ccaactggct ggcaagatga agctctccct ggtggccgcg atgctgctgc tgctcagcgc      300

ggcgcgggcc gaggaggagg acaagaagga ggacgtgggc acggtggtcg gcatcgacct      360

ggggaccacc tactcctgcg tcggcgtgtt caagaacggc cgcgtggaga tcatcgccaa      420

cgatcagggc aaccgcatca cgccgtccta tgtcgccttc actcctgaag gggaacgtct      480

gattggcgat gccgccaaga accagctcac ctccaacccc gagaacacgg tctttgacgc      540

caagcggctc atcggccgca cgtggaatga cccgtctgtg cagcaggaca tcaagttctt      600

gccgttcaag gtggttgaaa agaaaactaa accatacatt caagttgata ttggaggtgg      660

gcaaacaaag acatttgctc ctgaagaaat ttctgccatg gttctcacta aaatgaaaga      720

aaccgctgag gcttatttgg gaaagaaggt tacccatgca gttgttactg taccagccta      780

ttttaatgat gcccaacgcc aagcaaccaa agacgctgga actattgctg gcctaaatgt      840

tatgaggatc atcaacgagc ctacggcagc tgctattgct tatggcctgg ataagaggga      900

gggggagaag aacatcctgg tgtttgacct gggtggcgga accttcgatg tgtctcttct      960

caccattgac aatggtgtct tcgaagttgt ggccactaat ggagatactc atctgggtgg     1020

agaagacttt gaccagcgtg tcatggaaca cttcatcaaa ctgtacaaaa agaagacggg     1080

caaagatgtc aggaaagaca atagagctgt gcagaaactc cggcgcgagg tagaaaaggc     1140

caaacgggcc ctgtcttctc agcatcaagc aagaattgaa attgagtcct tctatgaagg     1200

agaagacttt tctgagaccc tgactcgggc caaatttgaa gagctcaaca tggatctgtt     1260

ccggtctact atgaagcccg tccagaaagt gttggaagat tctgatttga agaagtctga     1320

tattgatgaa attgttcttg ttggtggctc gactcgaatt ccaaagattc agcaactggt     1380

taaagagttc ttcaatggca aggaaccatc ccgtggcata aacccagatg aagctgtagc     1440

gtatggtgct gctgtccagg ctggtgtgct ctctggtgat caagatacag gtgacctggt     1500

actgcttgat gtatgtcccc ttacacttgg tattgaaact gtgggaggtg tcatgaccaa     1560

actgattcca aggaacacag tggtgcctac caagaagtct cagatctttt ctacagcttc     1620

tgataatcaa ccaactgtta caatcaaggt ctatgaaggt gaaagacccc tgacaaaaga     1680

caatcatctt ctgggtacat ttgatctgac tggaattcct cctgctcctc gtggggtccc     1740

acagattgaa gtcacctttg agatagatgt gaatggtatt cttcgagtga cagctgaaga     1800

caagggtaca gggaacaaaa ataagatcac aatcaccaat gaccagaatc gcctgacacc     1860

tgaagaaatc gaaaggatgg ttaatgatgc tgagaagttt gctgaggaag acaaaaagct     1920

caaggagcgc attgatacta gaaatgagtt ggaaagctat gcctattctc taaagaatca     1980

gattggagat aaagaaaagc tgggaggtaa actttcctct gaagataagg agaccatgga     2040

aaaagctgta gaagaaaaga ttgaatggct ggaaagccac caagatgctg acattgaaga     2100

cttcaaagct aagaagaagg aactggaaga aattgttcaa ccaattatca gcaaactcta     2160

tggaagtgca ggccctcccc caactggtga agaggataca gcagaaaaag atgagttgta     2220

gacactgatc tgctagtgct gtaatattgt aaatactgga ctcaggaact tttgttagga     2280

aaaaattgaa agaacttaag tctcgaatgt aattggaatc ttcacctcag agtggagttg     2340

aaactgctat agcctaagcg gctgtttact gcttttcatt agcagttgct cacatgtctt     2400

tgggtggggg ggagaagaag aattggccat cttaaaaagc gggtaaaaaa cctgggttag     2460

ggtgtgtgtt caccttcaaa atgttctatt taacaactgg gtcatgtgca tctggtgtag     2520

gaagtttttt ctaccataag tgacaccaat aaatgtttgt tatttacact ggtctaatgt     2580

ttgtgagaag cttctaatta gatcaattac ttattttagg aaatttaaga ctagatactc     2640

gtgtgtgggg tgaggggagg gagtatttgg tatgttggga taaggaaaca cttctattta     2700

atgcttccag ggattttttt tttttttttt aaccctcctg ggcccaagtg atccttccac     2760

ctcagtctcc cagctaattg agaccacagg cttgttacca ccatgctcgg cttttgcatt     2820

aatctaagaa aaggggagag aagttaatcc acatctttac tcaggcaagg ggcatttcac     2880

agtgcccaag agtggggttt tcttgaacat acttggtttc ctatttcccc ttatctttct     2940

aaaactgcct ttctggtggc tttttttaaa attattacta atgatgcttt tatagctgct     3000

tggattctct gagaaatgat ggggagtgag tgatcactgg tattaacttt atacacttgg     3060

atttcatttg taactttagg atgtaaaggt atattgtgaa ccctagctgt gtcagaatct     3120

ccatccctga aatttctcat tagtggtact ggggtgggat cttggatggt gacattgaaa     3180

ctacactaaa tcccctcact atgaatgggt tgttaaaggc aatggtttgt gtcaaaactg     3240

gtttaggatt acttagattg tgttcctgaa gaaaagagtc caggtaaatg gtatgatcaa     3300

taaaggacag gctggtgcta acataaaatc caatattgta atcctagcac tttgggaggc     3360

caaggcgggt ggatcacaag gtcaagagat agagaccatc tttgccaaca tggtgaaact     3420

ccatctctac tgaaaataca aaaattagct gggcgtggta gtgcaagctg aaggctgagg     3480

caggagaatc actcgaaccc gggaggcaga ggttgcagtg agccgagatc acaccactgt     3540

actccagccc ggcactccag cctggcgaca agagtgagac tccacctcaa aaaaaaaaaa     3600

aagaatccaa tactgcccaa ggataggtat tttatagatg ggcaactggc tgaaaggtta     3660

attctctagg gctagtagaa ctggatccca acaccaaact cttaattaga cctaggcctc     3720

agctgcactg cccgaaaagc atttgggcag accctgagca gaatactggt ctcaggccaa     3780

gcccaataca gccattaaag atgacctaca gtgctgtgta ccctggggca atagggttaa     3840

atggtagtta gcaactaggg ctagtcttcc cttacctcaa aggctctcac taccgtggac     3900

cacctagtct gtaactcttt ctgaggagct gttactgaat attaaaaaga tagacttcaa     3960

ctatg                                                                 3965


<210>  9
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Gly Leu Ser Met Asp Gly Gly Gly Ser Pro Lys Gly Asp Val 
1               5                   10                  15      


Asp Pro Phe Tyr Tyr Gly Lys Pro Gly Pro Leu Arg Thr Leu Pro Glu 
            20                  25                  30          


Pro Ser Gly Pro Leu Pro Pro Ser Ser Gly Leu Ser Gln Pro Gln Val 
        35                  40                  45              


His Ala Leu Cys Pro Leu Ser Pro Leu Val Thr Thr Gly Cys Cys Gly 
    50                  55                  60                  


Gln Ala Ala Glu Arg Asp Ser Cys Trp Glu Arg Pro Pro Ile Pro Leu 
65                  70                  75                  80  


Leu Leu Pro Ser Leu Ser Gly Asp Tyr Glu Thr Val Arg Asn Gly Gly 
                85                  90                  95      


Leu Ile Phe Ala Gly Leu Ala Phe Ile Val Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Ser Lys Trp Gly Gly Leu Gln Gly Arg Gly Ala Asp Gln Gly Thr Ser 
        115                 120                 125             


Leu Leu Lys Ala Ala Glu Gln Ala Gly Phe Arg Glu Leu Pro Arg Glu 
    130                 135                 140                 


Gly 
145 


<210>  10
<211>  2747
<212>  DNA
<213>  Homo sapiens

<400>  10
agacactctc caaaaagcag agacagcagg aagaggggag tggaggcagc ccattcacct       60

ggggaaatga ctgggttgtc gatggacggt ggcggcagcc ccaaggggga cgtggacccg      120

ttctactatg gtaagcctgg gcccctgcgc acccttcctg agccctcagg accccttcca      180

ccaagcagcg gcctctccca gccccaggtc catgctctgt gccccttatc tcccctggtt      240

accacgggct gctgcgggca ggctgcggag agagacagct gctgggagag accacccatc      300

ccgctcctct tgccctctct ttccggagac tatgagaccg ttcgcaatgg gggcctgatc      360

ttcgctggac tggccttcat cgtggggctc ctcatcctcc tcagtaagtg gggtggcctc      420

cagggaaggg gtgctgacca gggcacctct cttctcaagg ccgctgagca ggctggcttt      480

cgggagttgc caagggaggg gtgagcctcc ccaccacgcc ccccactgca ggatgtggga      540

atgggtgccc ggtggggtgc caggctcgct gggagcacag tgtgaggttc ctgcttgctc      600

aagtgcaccc tccagtgggc ccgggaggag ccgcagaagt gagagcaaac ccacggggta      660

actgggtaac cggagggcca gacaggggga ctaggccccc cgctgctaac catggtccca      720

aactcatttg ttaaataggg atgatcccac ctgcctcaca agattagggc tagcatccaa      780

agacatggca gtcaggacag cgctctgaga acggtccagt gcagactcgg agtgttctgg      840

gggagacaaa gagagttatg tatcctcaag ccccgagggg cacacagcag gagcttaata      900

actgcacatt gacttgtttt ggtccaaccc aaagaaaaat acacagaaaa cacaacccat      960

ggaaagaaga tacagcaagc acacctgtgg gctctggact tctaatgcac gtgtgccact     1020

gccaccccac cccaaggctc gggccacagt cctgcgggtc tccccatttt cccgtgttgc     1080

ccatggcagc tctctctacg tgtgccactg ccagcccacc ccaaggctcg ggccacagtc     1140

ctgcaggtct ccccattttc acatgttgcc cgtggcagct cccggagggc agtgccgggt     1200

ggcagctgat cacataggca caggaggcag gtggcctaag caaggggctc cactttggag     1260

ttgctgccat ccttctccag gtgttcatcg ggcagctgtg ctgggggcac catgatggcc     1320

cagtctctgc tgctactctc gatatgccaa cagaccaccg tggatctgct ccagtaaata     1380

tttgctgact gactgactga cttaggttct taaatgccta tggtccagcc ttatataaag     1440

agagagaagg ctgggcgtgg tggctcatgc ctgtaatgcc ggcatattag gaggccaagg     1500

caggaggatc tcttgagacc aggagtttaa gaccagcctg gtcaatacag tgagacccga     1560

tctatacaaa aaaaaatttt tttaattagc tgggcatggt gacatgtacc tatagtccca     1620

gctacttggg aggctgaggc aggaggatta cttgagccca ggagtttgag gctgcagtga     1680

gctacgatcc caccactgca ctccagcctg ggtgacagag taagaccccg tctcaaaaaa     1740

taaaataaaa taaaatataa aataaaatag agacagtcaa acgtggcctc caagcctgac     1800

cctgcgatga tactggcagg agggaggtag gagagactgg aagaattttg agtcttccag     1860

ggtctccttg gaaaattagt ccatggaaac aaatctcctt ttctcttttc aaggcagaag     1920

attccgctgt gggggcaata agaagcgcag gtgagcgctg cctggggtga ccgatgaggg     1980

ggttggggct ggagaaggag gggcgggctg aggattttgt ctctgacaca gtggaggatc     2040

cccagcctca gagatcccta gacccacccc tccccctgcc ctctcacctg ttgcttttcc     2100

ttcccccacc aggcaaatca atgaagatga gccgtaacag caggtatgct aggagggcct     2160

ggggaaggtg cggggagggc agggcaggct tgggagcaac agggaagaat tctggctcct     2220

ggactcggta aataagaatt ttagggtcgt ccacacatca gccaggtggt ctgtcaccca     2280

tcgtgtgttt aaaatgatgg ccaagggcct ggcgtggagt gtgtgccgca ggagatcaca     2340

gaggagccct ggagaaaagt gagatggaca agggggaagt aaaaccccaa cctctgctgc     2400

ctcccaccca accccatcct gcctttgtct tctcagcctc ggcggtgcca cccactgcac     2460

tggggccagc tgggaagcca agcatggccc tgcctctggc gcctcccctt cttccctggg     2520

ctttagacct ttgtccccgt cactgccagc gcttgggctg aaggaagctc cagactcaat     2580

gtgaccccca ggtggcatcg ccaactcctg cctcgtgcca cctcatgctt ataataaagc     2640

cggcgtcaga gaccgctgct tccctcacct gcctgcctgt ctccctcctc tgtcaccacc     2700

agcctctcca agctcaagta caaatacagc cgggaaaaaa aaaaaaa                   2747


<210>  11
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  11
cgactctaga ggatccatgg gcatcctgaa gctgcaag                               38


<210>  12
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  12
ccaatcccgg ggatccaagg ggcaagtaat tcagtgg                                37


<210>  13
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  13
cgactctaga ggatccatga tgtgcatctc caaactgcca gc                          42


<210>  14
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  14
ccaatcccgg ggatccaacg agtaagaaat ccaagg                                 36


