                         SEQUENCE LISTING

<110>  National Research Council of Canada
       KIM, Dae-Young
       TANHA, Jamshid
 
<120>  ENGINEERING OF IMMUNOGLOBULIN DOMAINS

<130>  12181-98

<140>  61/437,174
<141>  2011-01-28

<160>  108   

<170>  PatentIn version 3.5

<210>  1
<211>  125
<212>  PRT
<213>  Human - HVHAm302

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Val Ser Asp Glu 
            20                  25                  30          


Ser Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Asp Asn Arg Ser Cys Gln Thr Ser Leu Cys Thr Ser Thr Thr 
            100                 105                 110         


Arg Ser Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  2
<211>  125
<212>  PRT
<213>  Human - HVHAm302S

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Val Ser Asp Glu 
            20                  25                  30          


Ser Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Ala Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Cys Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Asp Asn Arg Ser Cys Gln Thr Ser Leu Cys Thr Ser Thr Thr 
            100                 105                 110         


Arg Ser Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  3
<211>  116
<212>  PRT
<213>  Human - HVHAm427

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Pro Glu 
            20                  25                  30          


Cys Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Cys Glu Gly Glu Asn Ala Phe Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  4
<211>  116
<212>  PRT
<213>  Human - HVHAm427S

<400>  4

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Leu Ser Pro Glu 
            20                  25                  30          


Cys Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Ala Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Cys Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Cys Glu Gly Glu Asn Ala Phe Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  5
<211>  125
<212>  PRT
<213>  Human - HVHAm431

<400>  5

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Val Ser Ser Glu 
            20                  25                  30          


Cys Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Lys Asn Cys His Asp Lys Asp Cys Thr Arg Pro Tyr 
            100                 105                 110         


Cys Ser Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  6
<211>  125
<212>  PRT
<213>  Human - HVHAm431S

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Val Ser Ser Glu 
            20                  25                  30          


Cys Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Ala Ile Ser Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Cys Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Ser Lys Asn Cys His Asp Lys Asp Cys Thr Arg Pro Tyr 
            100                 105                 110         


Cys Ser Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  7
<211>  119
<212>  PRT
<213>  Human - HVHPC235

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ile Ser Glu 
            20                  25                  30          


Ser Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Lys Ile Asp Gly Ala Arg Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  8
<211>  119
<212>  PRT
<213>  Human - HVHPC235S

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ile Ser Glu 
            20                  25                  30          


Ser Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Ala Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Cys Ser Arg Asp Asn Ser Lys Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Lys Ile Asp Gly Ala Arg Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  9
<211>  107
<212>  PRT
<213>  Human - HVLP324

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  10
<211>  107
<212>  PRT
<213>  Human - HVLP324S

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Cys 
        35                  40                  45              


Phe Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  11
<211>  106
<212>  PRT
<213>  Human - HVLP325

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Arg Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Val 
        35                  40                  45              


Phe Asp Thr Ser Asn Arg Ala Pro Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Leu Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Val Tyr Phe Cys Gln Gln Arg Ser Ser Gly Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105     


<210>  12
<211>  106
<212>  PRT
<213>  Human - HVLP325S

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Arg Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Cys 
        35                  40                  45              


Phe Asp Thr Ser Asn Arg Ala Pro Gly Val Pro Ala Arg Phe Ser Cys 
    50                  55                  60                  


Arg Gly Ser Gly Thr Leu Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Val Tyr Phe Cys Gln Gln Arg Ser Ser Gly Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105     


<210>  13
<211>  108
<212>  PRT
<213>  Human - HVLP335

<400>  13

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Asn Arg Leu Glu 
65                  70                  75                  80  


Pro Gly Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  14
<211>  108
<212>  PRT
<213>  Human - HVLP335S

<400>  14

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Cys Tyr Gly Thr Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Cys Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Asn Arg Leu Glu 
65                  70                  75                  80  


Pro Gly Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  15
<211>  107
<212>  PRT
<213>  Human - HVLP342

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Thr Asp 
            20                  25                  30          


Leu Asp Trp Phe Gln Gln Arg Pro Gly Arg Ala Pro His Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His His Thr Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Leu Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  16
<211>  107
<212>  PRT
<213>  Human - HVLP342S

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Thr Asp 
            20                  25                  30          


Leu Asp Trp Phe Gln Gln Arg Pro Gly Arg Ala Pro His Arg Leu Cys 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His His Thr Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Leu Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  17
<211>  107
<212>  PRT
<213>  Human - HVLP351

<400>  17

Glu Ile Val Met Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Ser Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Tyr Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  18
<211>  107
<212>  PRT
<213>  Human - HVLP351S

<400>  18

Glu Ile Val Met Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Cys 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Ser Ala Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Tyr Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  19
<211>  107
<212>  PRT
<213>  Human - HVLP364

<400>  19

Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Thr Thr Gly Ile Pro Asp Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Thr Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  20
<211>  107
<212>  PRT
<213>  Human - HVLP364S

<400>  20

Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Cys 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Thr Thr Gly Ile Pro Asp Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Thr Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  21
<211>  110
<212>  PRT
<213>  Human - HVLP389

<400>  21

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Tyr Asn Ile Gly Glu Asn 
            20                  25                  30          


Ser Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Asn Leu 
                85                  90                  95      


Arg Ala Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  22
<211>  110
<212>  PRT
<213>  Human - HVLP389S

<400>  22

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Tyr Asn Ile Gly Glu Asn 
            20                  25                  30          


Ser Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Cys Tyr Gly Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Cys Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Asn Leu 
                85                  90                  95      


Arg Ala Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  23
<211>  107
<212>  PRT
<213>  Human - HVLP3103

<400>  23

Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Val 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Thr Thr Pro Lys 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  24
<211>  107
<212>  PRT
<213>  Human - HVLP3103S

<400>  24

Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Cys 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Val 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Thr Thr Pro Lys 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  25
<211>  12
<212>  PRT
<213>  Human

<400>  25

Ser Cys Gln Thr Ser Leu Cys Thr Ser Thr Thr Arg 
1               5                   10          


<210>  26
<211>  19
<212>  PRT
<213>  Human

<400>  26

Leu Ser Cys Ala Ala Ser Gly Asp Thr Val Ser Asp Glu Ser Met Thr 
1               5                   10                  15      


Trp Val Arg 
            


<210>  27
<211>  14
<212>  PRT
<213>  Human

<400>  27

Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Thr Asp Asn Arg 
1               5                   10                  


<210>  28
<211>  12
<212>  PRT
<213>  Human

<400>  28

Ser Cys Gln Thr Ser Leu Cys Thr Ser Thr Thr Arg 
1               5                   10          


<210>  29
<211>  22
<212>  PRT
<213>  Human

<400>  29

Gly Leu Glu Trp Val Cys Ala Ile Ser Ser Ser Gly Gly Ser Thr Tyr 
1               5                   10                  15      


Tyr Ala Asp Ser Val Lys 
            20          


<210>  30
<211>  5
<212>  PRT
<213>  Human

<400>  30

Phe Thr Cys Ser Arg 
1               5   


<210>  31
<211>  19
<212>  PRT
<213>  Human

<400>  31

Leu Ser Cys Ala Ala Ser Gly Asp Thr Val Ser Asp Glu Ser Met Thr 
1               5                   10                  15      


Trp Val Arg 
            


<210>  32
<211>  14
<212>  PRT
<213>  Human

<400>  32

Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Thr Asp Asn Arg 
1               5                   10                  


<210>  33
<211>  22
<212>  PRT
<213>  Human

<400>  33

Gly Leu Glu Trp Val Cys Ala Ile Ser Ser Ser Gly Gly Ser Thr Tyr 
1               5                   10                  15      


Tyr Ala Asp Ser Val Lys 
            20          


<210>  34
<211>  5
<212>  PRT
<213>  Human

<400>  34

Phe Thr Cys Ser Arg 
1               5   


<210>  35
<211>  19
<212>  PRT
<213>  Human

<400>  35

Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ile Ser Glu Ser Met Thr 
1               5                   10                  15      


Trp Val Arg 
            


<210>  36
<211>  12
<212>  PRT
<213>  Human

<400>  36

Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Lys 
1               5                   10          


<210>  37
<211>  22
<212>  DNA
<213>  Human - M13RPa

<400>  37
tcacacagga aacagctatg ac                                                22


<210>  38
<211>  40
<212>  DNA
<213>  Human - KT131

<400>  38
accactacta ctaatagcgc agacccactc cagccccttc                             40


<210>  39
<211>  24
<212>  DNA
<213>  Human - M13FP

<400>  39
cgccagggtt ttcccagtca cgac                                              24


<210>  40
<211>  51
<212>  DNA
<213>  Human - KT129

<400>  40
gcagactccg tgaagggccg attcacctgc tccagagaca attccaagaa c                51


<210>  41
<211>  56
<212>  DNA
<213>  Human - KT130

<400>  41
tgcgctatta gtagtagtgg tggtagcaca tactacgcag actccgtgaa gggccg           56


<210>  42
<211>  6
<212>  PRT
<213>  Human

<400>  42

Val Thr Ile Thr Cys Arg 
1               5       


<210>  43
<211>  15
<212>  PRT
<213>  Human

<400>  43

Leu Leu Cys Phe Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
1               5                   10                  15  


<210>  44
<211>  34
<212>  PRT
<213>  Human

<400>  44

Phe Ser Cys Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn 
1               5                   10                  15      


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
            20                  25                  30          


Pro Arg 
        


<210>  45
<211>  6
<212>  PRT
<213>  Human

<400>  45

Ala Thr Leu Ser Cys Arg 
1               5       


<210>  46
<211>  26
<212>  PRT
<213>  Human

<400>  46

Gly Ser Gly Thr Leu Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
1               5                   10                  15      


Asp Ser Ala Val Tyr Phe Cys Gln Gln Arg 
            20                  25      


<210>  47
<211>  9
<212>  PRT
<213>  Human

<400>  47

Leu Leu Cys Phe Asp Thr Ser Asn Arg 
1               5                   


<210>  48
<211>  4
<212>  PRT
<213>  Human

<400>  48

Phe Ser Cys Arg 
1               


<210>  49
<211>  9
<212>  PRT
<213>  Human

<400>  49

Leu Leu Cys Tyr Gly Thr Ser Asn Arg 
1               5                   


<210>  50
<211>  16
<212>  PRT
<213>  Human

<400>  50

Phe Ser Cys Ser Gly Ser Gly Thr His Phe Thr Leu Thr Ile Val Arg 
1               5                   10                  15      


<210>  51
<211>  6
<212>  PRT
<213>  Human

<400>  51

Ala Thr Leu Ser Cys Arg 
1               5       


<210>  52
<211>  19
<212>  PRT
<213>  Human

<400>  52

Leu Glu Pro Gly Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser 
1               5                   10                  15      


Ser Pro Arg 
            


<210>  53
<211>  6
<212>  PRT
<213>  Human - HVHPM81S

<400>  53

Val Thr Ile Thr Cys Arg 
1               5       


<210>  54
<211>  15
<212>  PRT
<213>  Human

<400>  54

Leu Cys Tyr Gly Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg 
1               5                   10                  15  


<210>  55
<211>  35
<212>  PRT
<213>  Human

<400>  55

Phe Ser Cys Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly 
1               5                   10                  15      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His His Thr 
            20                  25                  30          


Tyr Pro Arg 
        35  


<210>  56
<211>  6
<212>  PRT
<213>  Human

<400>  56

Ala Thr Leu Ser Cys Arg 
1               5       


<210>  57
<211>  9
<212>  PRT
<213>  Human

<400>  57

Leu Leu Cys Tyr Asp Ala Ser Asn Arg 
1               5                   


<210>  58
<211>  30
<212>  PRT
<213>  Human

<400>  58

Phe Ser Cys Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
1               5                   10                  15      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg 
            20                  25                  30  


<210>  59
<211>  11
<212>  PRT
<213>  Human

<400>  59

Leu Leu Cys Tyr Gly Ala Ser Ser Arg Thr Arg 
1               5                   10      


<210>  60
<211>  16
<212>  PRT
<213>  Human

<400>  60

Phe Ser Cys Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
1               5                   10                  15      


<210>  61
<211>  6
<212>  PRT
<213>  Human

<400>  61

Ala Thr Phe Ser Cys Arg 
1               5       


<210>  62
<211>  19
<212>  PRT
<213>  Human

<400>  62

Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Thr 
1               5                   10                  15      


Ser Pro Arg 
            


<210>  63
<211>  8
<212>  PRT
<213>  Human

<400>  63

Leu Leu Cys Tyr Gly Asn Asp Lys 
1               5               


<210>  64
<211>  5
<212>  PRT
<213>  Human

<400>  64

Phe Ser Cys Ser Lys 
1               5   


<210>  65
<211>  29
<212>  PRT
<213>  Human

<400>  65

Val Thr Ile Ser Cys Ser Gly Ser Ser Tyr Asn Ile Gly Glu Asn Ser 
1               5                   10                  15      


Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
            20                  25                  


<210>  66
<211>  30
<212>  PRT
<213>  Human

<400>  66

Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp 
1               5                   10                  15      


Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Asn Leu Arg 
            20                  25                  30  


<210>  67
<211>  6
<212>  PRT
<213>  Human

<400>  67

Ala Thr Leu Ser Cys Arg 
1               5       


<210>  68
<211>  9
<212>  PRT
<213>  Human

<400>  68

Leu Leu Cys Tyr Gly Ala Ser Thr Arg 
1               5                   


<210>  69
<211>  35
<212>  PRT
<213>  Human

<400>  69

Phe Ser Cys Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
1               5                   10                  15      


Leu Gln Val Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Thr 
            20                  25                  30          


Thr Pro Lys 
        35  


<210>  70
<211>  124
<212>  PRT
<213>  Human - HVHP44S

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Cys Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Glu Pro Arg Ser Val Ser Gly Leu Arg Gly Val Val Asp 
            100                 105                 110         


Ser Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  71
<211>  113
<212>  PRT
<213>  Human - HVHB82S

<400>  71

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Cys Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Thr Asp Met Glu Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  72
<211>  123
<212>  PRT
<213>  Human - HVHP421S

<400>  72

Gln Leu Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Cys Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Lys Gly Gly Ser Ser Gly Tyr Asp His Pro Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  73
<211>  122
<212>  PRT
<213>  Human - HVHP419S

<400>  73

Gln Leu Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Cys Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gly Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Trp Ser Gly Ser Ser Tyr Gly Gly Asp Leu Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  74
<211>  125
<212>  PRT
<213>  Human - HVHP430S

<400>  74

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Ala Ile Ser Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Cys Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Glu Tyr Arg Cys Ser Gly Thr Ser Cys Pro Gly Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  75
<211>  119
<212>  PRT
<213>  Human - HVHP429S

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ile Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Asp Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Cys Thr Ile Ser Asn Asn Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Cys Ser Arg Asp Asn Ser Asn Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Ile Asn Thr Gly Arg Tyr Gly Asp Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  76
<211>  123
<212>  PRT
<213>  Human - HVHM41S

<400>  76

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Ala Ile Ser Gly Gly Gly Asp His Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Cys Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Met Val Arg Gly Val Ser Ser Ala Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  77
<211>  121
<212>  PRT
<213>  Human - HVHM81S

<400>  77

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Gly Ile Ser Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Cys Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ser Ile Thr Gly Pro Thr Gly Ala Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  78
<211>  123
<212>  PRT
<213>  Human - HVHP428S

<400>  78

Gln Leu Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Cys Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Arg Ala Lys Asp Gly Tyr Asn Ser Pro Glu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  79
<211>  119
<212>  PRT
<213>  Human - HVHP420S

<400>  79

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Arg Ile Lys Thr Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Cys Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Asp His Ser Ser Gly Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  80
<211>  119
<212>  PRT
<213>  Human - HVHP414S

<400>  80

Asp Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Pro Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Arg Ile Thr Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Val Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Cys Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Gln Ala Asn Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  81
<211>  118
<212>  PRT
<213>  Human - HVHP423S

<400>  81

Gln Met Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Ser 
            20                  25                  30          


Arg Met Ser Trp Phe Arg Gln Ala Pro Gly Met Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Ser Cys Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Arg Glu Gly Ala Val Thr Arg Glu Asp Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  82
<211>  119
<212>  PRT
<213>  Human - HVHP413S

<400>  82

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Phe Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Cys Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Ser Arg Val Gly Gly Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  83
<211>  120
<212>  PRT
<213>  Human - HVHP426S

<400>  83

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val Asp Gly Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Cys Val Thr Asn Asn Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Cys Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gln Ser Ile Thr Gly Pro Thr Gly Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  84
<211>  25
<212>  PRT
<213>  Human

<400>  84

Gln Ala Pro Gly Gln Gly Val Glu Trp Val Cys Val Thr Asn Asn Gly 
1               5                   10                  15      


Gly Ser Thr Ser Ala Asp Ser Val Lys 
            20                  25  


<210>  85
<211>  5
<212>  PRT
<213>  Human

<400>  85

Phe Thr Cys Ser Arg 
1               5   


<210>  86
<211>  8
<212>  PRT
<213>  Human

<400>  86

Gly Ser Gly Ser Lys Ala Ala Ala 
1               5               


<210>  87
<211>  69
<212>  DNA
<213>  Human - VL24-CDR1


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (21)..(21)
<223>  k is t or g

<220>
<221>  r
<222>  (31)..(31)
<223>  r is a or g

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (39)..(39)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (42)..(42)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (43)..(44)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (45)..(45)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (51)..(51)
<223>  k is t or g

<400>  87
agagtcacca tcacttgcnn kgcaagtcag rgcattnnkn nknnkttann ktggtatcag       60

cagaaacca                                                               69


<210>  88
<211>  54
<212>  DNA
<213>  Human - VL24S-CDR2


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (21)..(21)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (30)..(30)
<223>  k is t or g

<220>
<221>  k
<222>  (32)..(32)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (33)..(35)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (36)..(36)
<223>  k is t or g

<400>  88
cctaaactcc tgtgctttnn kgcatccnnk cknnnkagtg gggtcccatc aagg             54


<210>  89
<211>  60
<212>  DNA
<213>  Human - VL24-CDR3


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (21)..(21)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (27)..(27)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (30)..(30)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (33)..(33)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (36)..(36)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (42)..(42)
<223>  k is t or g

<400>  89
tttgcaactt actactgtnn kcagnnknnk nnknnkcctn nkacgttcgg ccacgggacc       60


<210>  90
<211>  63
<212>  DNA
<213>  Human - VL24-CDR3a


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (30)..(30)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (36)..(36)
<223>  k is t or g

<220>
<221>  k
<222>  (39)..(39)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (42)..(42)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (43)..(44)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (44)..(44)
<223>  k is t or g

<220>
<221>  k
<222>  (51)..(51)
<223>  k is t or g

<220>
<221>  k
<222>  (54)..(54)
<223>  k is t or g

<400>  90
tttgcaactt actactgtnn kcagnnknnk nnknnkcctn nknnkacgtt cggccacggg       60

acc                                                                     63


<210>  91
<211>  66
<212>  DNA
<213>  Human - VL24-CDR3b


<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (30)..(30)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (36)..(36)
<223>  k is t or g

<220>
<221>  k
<222>  (39)..(39)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (42)..(42)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (43)..(44)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (45)..(45)
<223>  k is t or g

<220>
<221>  misc_feature
<222>  (46)..(47)
<223>  n is a, c, g, or t

<220>
<221>  k
<222>  (51)..(51)
<223>  k is t or g

<220>
<221>  k
<222>  (54)..(54)
<223>  k is t or g

<220>
<221>  k
<222>  (57)..(57)
<223>  k is t or g

<400>  91
tttgcaactt actactgtnn kcagnnknnk nnknnkcctn nknnknnkac gttcggccac       60

gggacc                                                                  66


<210>  92
<211>  24
<212>  DNA
<213>  Human - -96GIII

<400>  92
ccctcatagt tagcgtaacg atct                                              24


<210>  93
<211>  27
<212>  DNA
<213>  Human - fdTGIII

<400>  93
gtgaaaaaat tattattcgc aattcct                                           27


<210>  94
<211>  26
<212>  DNA
<213>  Human - HVL24-BamHI

<400>  94
ttgttcggat cctaggacgg tcacct                                            26


<210>  95
<211>  26
<212>  DNA
<213>  Human - HVL24-BbsI

<400>  95
tatgaagaca ccaggccgac atccag                                            26


<210>  96
<211>  54
<212>  DNA
<213>  Human - KT124

<400>  96
tgtgctacca ccactactac taatagcgca gacccactcc agccccttcc ctgg             54


<210>  97
<211>  54
<212>  DNA
<213>  Human - KT125

<400>  97
cacggtgttc ttggaattgt ctctggagca ggtgaatcgg cccttcacgg agtc             54


<210>  98
<211>  17
<212>  DNA
<213>  Human - M13RPb

<400>  98
caggaaacag ctatgac                                                      17


<210>  99
<211>  107
<212>  PRT
<213>  Human - HVLHLNN

<400>  99

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Ser Ile Asn Asn Arg 
            20                  25                  30          


Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Cys 
        35                  40                  45              


Phe Pro Ala Ser Phe Leu Phe Ser Gly Val Pro Ser Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  100
<211>  107
<212>  PRT
<213>  Human - HVLHLDS

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Thr Val Ser Gln Gly Ile Asp Ser Arg 
            20                  25                  30          


Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Cys 
        35                  40                  45              


Phe Pro Ala Ser Leu Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  101
<211>  109
<212>  PRT
<213>  Human - HVLHLRN

<400>  101

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Gly Ile Arg Asn Arg 
            20                  25                  30          


Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Cys 
        35                  40                  45              


Phe Pro Ala Ser Ile Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gln Pro Gly Leu Pro Asn 
                85                  90                  95      


Ser Arg Thr Phe Gly His Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  102
<211>  107
<212>  PRT
<213>  Human - HVLHLNE

<400>  102

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Asp Ala Ser Gln Ser Ile Asn Glu Arg 
            20                  25                  30          


Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Cys 
        35                  40                  45              


Phe Pro Ala Ser Ile Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Pro Arg Ser Gly Pro Ser 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  103
<211>  108
<212>  PRT
<213>  Human - HVLHLAQ

<400>  103

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Gln Ser Ile Ala Gln Arg 
            20                  25                  30          


Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Cys 
        35                  40                  45              


Phe Pro Ala Ser Leu Leu His Ser Gly Val Pro Ser Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Arg Ala Ser Pro Pro Arg 
                85                  90                  95      


Pro Thr Phe Gly His Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  104
<211>  109
<212>  PRT
<213>  Human - HVLHLEM

<400>  104

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Ile Glu Met Phe 
            20                  25                  30          


Leu Gln Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Cys 
        35                  40                  45              


Phe Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Pro Gly Val Ala Pro Pro 
                85                  90                  95      


Pro Gly Thr Phe Gly His Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  105
<211>  108
<212>  PRT
<213>  Human - HVLHLQI

<400>  105

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gln Ile Met 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Cys 
        35                  40                  45              


Phe Gly Ala Ser Phe Leu Ile Ser Gly Val Pro Ser Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Thr Trp Thr Pro Pro Ala 
                85                  90                  95      


Pro Thr Phe Gly His Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  106
<211>  107
<212>  PRT
<213>  Human - HVLHLYS

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Tyr Ser Lys 
            20                  25                  30          


Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Cys 
        35                  40                  45              


Phe Pro Ala Ser Leu Leu Trp Ser Gly Val Pro Ser Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Ala Ala Asp Pro His 
                85                  90                  95      


Arg Thr Phe Gly His Gly Thr Lys Val Arg Leu 
            100                 105         


<210>  107
<211>  109
<212>  PRT
<213>  Human - HVLHSA1

<400>  107

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Cys 
        35                  40                  45              


Phe Gly Ala Ser Arg Leu Asn Ser Gly Val Pro Ser Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Leu Phe Pro Leu Pro Asp 
                85                  90                  95      


Arg Arg Thr Phe Gly His Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  108
<211>  107
<212>  PRT
<213>  Human - HVLHLFL

<400>  108

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Gln Ser Ile Phe Leu Tyr 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Cys 
        35                  40                  45              


Phe Phe Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Cys 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly His Gly Thr Lys Val Thr Val Leu 
            100                 105         


