                         SEQUENCE LISTING

<110>  Albert Einstein College of Medicine of Yeshiva University
       President and Fellows of Harvard College
       Whitehead Institute for Biomedical Research
 
<120>  METHODS AND ASSAYS FOR TREATING FILOVIRIDAE INFECTIONS

<130>  96700/1788

<150>  US 61/435,858
<151>  2011-01-25

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  1278
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Ala Arg Gly Leu Ala Leu Gly Leu Leu Leu Leu Leu Leu Cys 
1               5                   10                  15      


Pro Ala Gln Val Phe Ser Gln Ser Cys Val Trp Tyr Gly Glu Cys Gly 
            20                  25                  30          


Ile Ala Tyr Gly Asp Lys Arg Tyr Asn Cys Glu Tyr Ser Gly Pro Pro 
        35                  40                  45              


Lys Pro Leu Pro Lys Asp Gly Tyr Asp Leu Val Gln Glu Leu Cys Pro 
    50                  55                  60                  


Gly Phe Phe Phe Gly Asn Val Ser Leu Cys Cys Asp Val Arg Gln Leu 
65                  70                  75                  80  


Gln Thr Leu Lys Asp Asn Leu Gln Leu Pro Leu Gln Phe Leu Ser Arg 
                85                  90                  95      


Cys Pro Ser Cys Phe Tyr Asn Leu Leu Asn Leu Phe Cys Glu Leu Thr 
            100                 105                 110         


Cys Ser Pro Arg Gln Ser Gln Phe Leu Asn Val Thr Ala Thr Glu Asp 
        115                 120                 125             


Tyr Val Asp Pro Val Thr Asn Gln Thr Lys Thr Asn Val Lys Glu Leu 
    130                 135                 140                 


Gln Tyr Tyr Val Gly Gln Ser Phe Ala Asn Ala Met Tyr Asn Ala Cys 
145                 150                 155                 160 


Arg Asp Val Glu Ala Pro Ser Ser Asn Asp Lys Ala Leu Gly Leu Leu 
                165                 170                 175     


Cys Gly Lys Asp Ala Asp Ala Cys Asn Ala Thr Asn Trp Ile Glu Tyr 
            180                 185                 190         


Met Phe Asn Lys Asp Asn Gly Gln Ala Pro Phe Thr Ile Thr Pro Val 
        195                 200                 205             


Phe Ser Asp Phe Pro Val His Gly Met Glu Pro Met Asn Asn Ala Thr 
    210                 215                 220                 


Lys Gly Cys Asp Glu Ser Val Asp Glu Val Thr Ala Pro Cys Ser Cys 
225                 230                 235                 240 


Gln Asp Cys Ser Ile Val Cys Gly Pro Lys Pro Gln Pro Pro Pro Pro 
                245                 250                 255     


Pro Ala Pro Trp Thr Ile Leu Gly Leu Asp Ala Met Tyr Val Ile Met 
            260                 265                 270         


Trp Ile Thr Tyr Met Ala Phe Leu Leu Val Phe Phe Gly Ala Phe Phe 
        275                 280                 285             


Ala Val Trp Cys Tyr Arg Lys Arg Tyr Phe Val Ser Glu Tyr Thr Pro 
    290                 295                 300                 


Ile Asp Ser Asn Ile Ala Phe Ser Val Asn Ala Ser Asp Lys Gly Glu 
305                 310                 315                 320 


Ala Ser Cys Cys Asp Pro Val Ser Ala Ala Phe Glu Gly Cys Leu Arg 
                325                 330                 335     


Arg Leu Phe Thr Arg Trp Gly Ser Phe Cys Val Arg Asn Pro Gly Cys 
            340                 345                 350         


Val Ile Phe Phe Ser Leu Val Phe Ile Thr Ala Cys Ser Ser Gly Leu 
        355                 360                 365             


Val Phe Val Arg Val Thr Thr Asn Pro Val Asp Leu Trp Ser Ala Pro 
    370                 375                 380                 


Ser Ser Gln Ala Arg Leu Glu Lys Glu Tyr Phe Asp Gln His Phe Gly 
385                 390                 395                 400 


Pro Phe Phe Arg Thr Glu Gln Leu Ile Ile Arg Ala Pro Leu Thr Asp 
                405                 410                 415     


Lys His Ile Tyr Gln Pro Tyr Pro Ser Gly Ala Asp Val Pro Phe Gly 
            420                 425                 430         


Pro Pro Leu Asp Ile Gln Ile Leu His Gln Val Leu Asp Leu Gln Ile 
        435                 440                 445             


Ala Ile Glu Asn Ile Thr Ala Ser Tyr Asp Asn Glu Thr Val Thr Leu 
    450                 455                 460                 


Gln Asp Ile Cys Leu Ala Pro Leu Ser Pro Tyr Asn Thr Asn Cys Thr 
465                 470                 475                 480 


Ile Leu Ser Val Leu Asn Tyr Phe Gln Asn Ser His Ser Val Leu Asp 
                485                 490                 495     


His Lys Lys Gly Asp Asp Phe Phe Val Tyr Ala Asp Tyr His Thr His 
            500                 505                 510         


Phe Leu Tyr Cys Val Arg Ala Pro Ala Ser Leu Asn Asp Thr Ser Leu 
        515                 520                 525             


Leu His Asp Pro Cys Leu Gly Thr Phe Gly Gly Pro Val Phe Pro Trp 
    530                 535                 540                 


Leu Val Leu Gly Gly Tyr Asp Asp Gln Asn Tyr Asn Asn Ala Thr Ala 
545                 550                 555                 560 


Leu Val Ile Thr Phe Pro Val Asn Asn Tyr Tyr Asn Asp Thr Glu Lys 
                565                 570                 575     


Leu Gln Arg Ala Gln Ala Trp Glu Lys Glu Phe Ile Asn Phe Val Lys 
            580                 585                 590         


Asn Tyr Lys Asn Pro Asn Leu Thr Ile Ser Phe Thr Ala Glu Arg Ser 
        595                 600                 605             


Ile Glu Asp Glu Leu Asn Arg Glu Ser Asp Ser Asp Val Phe Thr Val 
    610                 615                 620                 


Val Ile Ser Tyr Ala Ile Met Phe Leu Tyr Ile Ser Leu Ala Leu Gly 
625                 630                 635                 640 


His Met Lys Ser Cys Arg Arg Leu Leu Val Asp Ser Lys Val Ser Leu 
                645                 650                 655     


Gly Ile Ala Gly Ile Leu Ile Val Leu Ser Ser Val Ala Cys Ser Leu 
            660                 665                 670         


Gly Val Phe Ser Tyr Ile Gly Leu Pro Leu Thr Leu Ile Val Ile Glu 
        675                 680                 685             


Val Ile Pro Phe Leu Val Leu Ala Val Gly Val Asp Asn Ile Phe Ile 
    690                 695                 700                 


Leu Val Gln Ala Tyr Gln Arg Asp Glu Arg Leu Gln Gly Glu Thr Leu 
705                 710                 715                 720 


Asp Gln Gln Leu Gly Arg Val Leu Gly Glu Val Ala Pro Ser Met Phe 
                725                 730                 735     


Leu Ser Ser Phe Ser Glu Thr Val Ala Phe Phe Leu Gly Ala Leu Ser 
            740                 745                 750         


Val Met Pro Ala Val His Thr Phe Ser Leu Phe Ala Gly Leu Ala Val 
        755                 760                 765             


Phe Ile Asp Phe Leu Leu Gln Ile Thr Cys Phe Val Ser Leu Leu Gly 
    770                 775                 780                 


Leu Asp Ile Lys Arg Gln Glu Lys Asn Arg Leu Asp Ile Phe Cys Cys 
785                 790                 795                 800 


Val Arg Gly Ala Glu Asp Gly Thr Ser Val Gln Ala Ser Glu Ser Cys 
                805                 810                 815     


Leu Phe Arg Phe Phe Lys Asn Ser Tyr Ser Pro Leu Leu Leu Lys Asp 
            820                 825                 830         


Trp Met Arg Pro Ile Val Ile Ala Ile Phe Val Gly Val Leu Ser Phe 
        835                 840                 845             


Ser Ile Ala Val Leu Asn Lys Val Asp Ile Gly Leu Asp Gln Ser Leu 
    850                 855                 860                 


Ser Met Pro Asp Asp Ser Tyr Met Val Asp Tyr Phe Lys Ser Ile Ser 
865                 870                 875                 880 


Gln Tyr Leu His Ala Gly Pro Pro Val Tyr Phe Val Leu Glu Glu Gly 
                885                 890                 895     


His Asp Tyr Thr Ser Ser Lys Gly Gln Asn Met Val Cys Gly Gly Met 
            900                 905                 910         


Gly Cys Asn Asn Asp Ser Leu Val Gln Gln Ile Phe Asn Ala Ala Gln 
        915                 920                 925             


Leu Asp Asn Tyr Thr Arg Ile Gly Phe Ala Pro Ser Ser Trp Ile Asp 
    930                 935                 940                 


Asp Tyr Phe Asp Trp Val Lys Pro Gln Ser Ser Cys Cys Arg Val Asp 
945                 950                 955                 960 


Asn Ile Thr Asp Gln Phe Cys Asn Ala Ser Val Val Asp Pro Ala Cys 
                965                 970                 975     


Val Arg Cys Arg Pro Leu Thr Pro Glu Gly Lys Gln Arg Pro Gln Gly 
            980                 985                 990         


Gly Asp Phe Met Arg Phe Leu Pro  Met Phe Leu Ser Asp  Asn Pro Asn 
        995                 1000                 1005             


Pro Lys  Cys Gly Lys Gly Gly  His Ala Ala Tyr Ser  Ser Ala Val 
    1010                 1015                 1020             


Asn Ile  Leu Leu Gly His Gly  Thr Arg Val Gly Ala  Thr Tyr Phe 
    1025                 1030                 1035             


Met Thr  Tyr His Thr Val Leu  Gln Thr Ser Ala Asp  Phe Ile Asp 
    1040                 1045                 1050             


Ala Leu  Lys Lys Ala Arg Leu  Ile Ala Ser Asn Val  Thr Glu Thr 
    1055                 1060                 1065             


Met Gly  Ile Asn Gly Ser Ala  Tyr Arg Val Phe Pro  Tyr Ser Val 
    1070                 1075                 1080             


Phe Tyr  Val Phe Tyr Glu Gln  Tyr Leu Thr Ile Ile  Asp Asp Thr 
    1085                 1090                 1095             


Ile Phe  Asn Leu Gly Val Ser  Leu Gly Ala Ile Phe  Leu Val Thr 
    1100                 1105                 1110             


Met Val  Leu Leu Gly Cys Glu  Leu Trp Ser Ala Val  Ile Met Cys 
    1115                 1120                 1125             


Ala Thr  Ile Ala Met Val Leu  Val Asn Met Phe Gly  Val Met Trp 
    1130                 1135                 1140             


Leu Trp  Gly Ile Ser Leu Asn  Ala Val Ser Leu Val  Asn Leu Val 
    1145                 1150                 1155             


Met Ser  Cys Gly Ile Ser Val  Glu Phe Cys Ser His  Ile Thr Arg 
    1160                 1165                 1170             


Ala Phe  Thr Val Ser Met Lys  Gly Ser Arg Val Glu  Arg Ala Glu 
    1175                 1180                 1185             


Glu Ala  Leu Ala His Met Gly  Ser Ser Val Phe Ser  Gly Ile Thr 
    1190                 1195                 1200             


Leu Thr  Lys Phe Gly Gly Ile  Val Val Leu Ala Phe  Ala Lys Ser 
    1205                 1210                 1215             


Gln Ile  Phe Gln Ile Phe Tyr  Phe Arg Met Tyr Leu  Ala Met Val 
    1220                 1225                 1230             


Leu Leu  Gly Ala Thr His Gly  Leu Ile Phe Leu Pro  Val Leu Leu 
    1235                 1240                 1245             


Ser Tyr  Ile Gly Pro Ser Val  Asn Lys Ala Lys Ser  Cys Ala Thr 
    1250                 1255                 1260             


Glu Glu  Arg Tyr Lys Gly Thr  Glu Arg Glu Arg Leu  Leu Asn Phe 
    1265                 1270                 1275             


<210>  2
<211>  4827
<212>  DNA
<213>  Homo sapiens

<400>  2
gaagggcaac acggggacct tgaagcgggg tcgcggcggc gccccagccc gggccaggga       60

gtcccggcag cggcacctcc cagaaagggc ggagccgacg acgccttctt ccttcctgac      120

cggcgcgcgc agcctgctgc cgcggtcagc gcctgctcct gctcctccgc tcctcctgcg      180

cggggtgctg aaacagcccg gggaagtaga gccgcctccg gggagcccaa ccagccgaac      240

gccgccggcg tcagcagcct tgcgcggcca cagcatgacc gctcgcggcc tggcccttgg      300

cctcctcctg ctgctactgt gtccagcgca ggtgttttca cagtcctgtg tttggtatgg      360

agagtgtgga attgcatatg gggacaagag gtacaattgc gaatattctg gcccaccaaa      420

accattgcca aaggatggat atgacttagt gcaggaactc tgtccaggat tcttctttgg      480

caatgtcagt ctctgttgtg atgttcggca gcttcagaca ctaaaagaca acctgcagct      540

gcctctacag tttctgtcca gatgtccatc ctgtttttat aacctactga acctgttttg      600

tgagctgaca tgtagccctc gacagagtca gtttttgaat gttacagcta ctgaagatta      660

tgttgatcct gttacaaacc agacgaaaac aaatgtgaaa gagttacaat actacgtcgg      720

acagagtttt gccaatgcaa tgtacaatgc ctgccgggat gtggaggccc cctcaagtaa      780

tgacaaggcc ctgggactcc tgtgtgggaa ggacgctgac gcctgtaatg ccaccaactg      840

gattgaatac atgttcaata aggacaatgg acaggcacct tttaccatca ctcctgtgtt      900

ttcagatttt ccagtccatg ggatggagcc catgaacaat gccaccaaag gctgtgacga      960

gtctgtggat gaggtcacag caccatgtag ctgccaagac tgctctattg tctgtggccc     1020

caagccccag cccccacctc ctcctgctcc ctggacgatc cttggcttgg acgccatgta     1080

tgtcatcatg tggatcacct acatggcgtt tttgcttgtg ttttttggag cattttttgc     1140

agtgtggtgc tacagaaaac ggtattttgt ctccgagtac actcccatcg atagcaatat     1200

agctttttct gttaatgcaa gtgacaaagg agaggcgtcc tgctgtgacc ctgtcagcgc     1260

agcatttgag ggctgcttga ggcggctgtt cacacgctgg gggtctttct gcgtccgaaa     1320

ccctggctgt gtcattttct tctcgctggt cttcattact gcgtgttcgt caggcctggt     1380

gtttgtccgg gtcacaacca atccagttga cctctggtca gcccccagca gccaggctcg     1440

cctggaaaaa gagtactttg accagcactt tgggcctttc ttccggacgg agcagctcat     1500

catccgggcc cctctcactg acaaacacat ttaccagcca tacccttcgg gagctgatgt     1560

accctttgga cctccgcttg acatacagat actgcaccag gttcttgact tacaaatagc     1620

catcgaaaac attactgcct cttatgacaa tgagactgtg acacttcaag acatctgctt     1680

ggcccctctt tcaccgtata acacgaactg caccattttg agtgtgttaa attacttcca     1740

gaacagccat tccgtgctgg accacaagaa aggggacgac ttctttgtgt atgccgatta     1800

ccacacgcac tttctgtact gcgtacgggc tcctgcctct ctgaatgata caagtttgct     1860

ccatgaccct tgtctgggta cgtttggtgg accagtgttc ccgtggcttg tgttgggagg     1920

ctatgatgat caaaactaca ataacgccac tgcccttgtg attaccttcc ctgtcaataa     1980

ttactataat gatacagaga agctccagag ggcccaggcc tgggaaaaag agtttattaa     2040

ttttgtgaaa aactacaaga atcccaatct gaccatttcc ttcactgctg aacgaagtat     2100

tgaagatgaa ctaaatcgtg aaagtgacag tgatgtcttc accgttgtaa ttagctatgc     2160

catcatgttt ctatatattt ccctagcctt ggggcacatg aaaagctgtc gcaggcttct     2220

ggtggattcg aaggtctcac taggcatcgc gggcatcttg atcgtgctga gctcggtggc     2280

ttgctccttg ggtgtcttca gctacattgg gttgcccttg accctcattg tgattgaagt     2340

catcccgttc ctggtgctgg ctgttggagt ggacaacatc ttcattctgg tgcaggccta     2400

ccagagagat gaacgtcttc aaggggaaac cctggatcag cagctgggca gggtcctagg     2460

agaagtggct cccagtatgt tcctgtcatc cttttctgag actgtagcat ttttcttagg     2520

agcattgtcc gtgatgccag ccgtgcacac cttctctctc tttgcgggat tggcagtctt     2580

cattgacttt cttctgcaga ttacctgttt cgtgagtctc ttggggttag acattaaacg     2640

tcaagagaaa aatcggctag acatcttttg ctgtgtcaga ggtgctgaag atggaacaag     2700

cgtccaggcc tcagagagct gtttgtttcg cttcttcaaa aactcctatt ctccacttct     2760

gctaaaggac tggatgagac caattgtgat agcaatattt gtgggtgttc tgtcattcag     2820

catcgcagtc ctgaacaaag tagatattgg attggatcag tctctttcga tgccagatga     2880

ctcctacatg gtggattatt tcaaatccat cagtcagtac ctgcatgcgg gtccgcctgt     2940

gtactttgtc ctggaggaag ggcacgacta cacttcttcc aaggggcaga acatggtgtg     3000

cggcggcatg ggctgcaaca atgattccct ggtgcagcag atatttaacg cggcgcagct     3060

ggacaactat acccgaatag gcttcgcccc ctcgtcctgg atcgacgatt atttcgactg     3120

ggtgaagcca cagtcgtctt gctgtcgagt ggacaatatc actgaccagt tctgcaatgc     3180

ttcagtggtt gaccctgcct gcgttcgctg caggcctctg actccggaag gcaaacagag     3240

gcctcagggg ggagacttca tgagattcct gcccatgttc ctttcggata accctaaccc     3300

caagtgtggc aaagggggac atgctgccta tagttctgca gttaacatcc tccttggcca     3360

tggcaccagg gtcggagcca cgtacttcat gacctaccac accgtgctgc agacctctgc     3420

tgactttatt gacgctctga agaaagcccg acttatagcc agtaatgtca ccgaaaccat     3480

gggcattaac ggcagtgcct accgagtatt tccttacagt gtgttttatg tcttctacga     3540

acagtacctg accatcattg acgacactat cttcaacctc ggtgtgtccc tgggcgcgat     3600

atttctggtg accatggtcc tcctgggctg tgagctctgg tctgcagtca tcatgtgtgc     3660

caccatcgcc atggtcttgg tcaacatgtt tggagttatg tggctctggg gcatcagtct     3720

gaacgctgta tccttggtca acctggtgat gagctgtggc atctccgtgg agttctgcag     3780

ccacataacc agagcgttca cggtgagcat gaaaggcagc cgcgtggagc gcgcggaaga     3840

ggcacttgcc cacatgggca gctccgtgtt cagtggaatc acacttacaa aatttggagg     3900

gattgtggtg ttggcttttg ccaaatctca aattttccag atattctact tcaggatgta     3960

tttggccatg gtcttactgg gagccactca cggattaata tttctccctg tcttactcag     4020

ttacataggg ccatcagtaa ataaagccaa aagttgtgcc actgaagagc gatacaaagg     4080

aacagagcgc gaacggcttc taaatttcta gccctctcgc agggcatcct gactgaactg     4140

tgtctaaggg tcggtcggtt taccactgga cgggtgctgc atcggcaagg ccaagttgaa     4200

caccggatgg tgccaaccat cggttgtttg gcagcagctt tgaacgtagc gcctgtgaac     4260

tcaggaatgc acagttgact tgggaagcag tattactaga tctggaggca accacaggac     4320

actaaacttc tcccagcctc ttcaggaaag aaacctcatt ctttggcaag caggaggtga     4380

cactagatgg ctgtgaatgt gatccgctca ctgacactct gtaaaggcca atcaatgcac     4440

tgtctgtctc tccttttagg agtaagccat cccacaagtt ctataccata tttttagtga     4500

cagttgaggt tgtagataca ctttataaca ttttatagtt taaagagctt tattaatgca     4560

ataaattaac tttgtacaca tttttatata aaaaaacagc aagtgatttc agaatgttgt     4620

aggcctcatt agagcttggt ctccaaaaat ctgtttgaaa aaagcaacat gttcttcaca     4680

gtgttcccct agaaaggaag agatttaatt gccagttaga tgtggcatga aatgagggac     4740

aaagaaagca tctcgtaggt gtgtctactg ggttttaact tatttttctt taataaaata     4800

cattgttttc ctaaaaaaaa aaaaaaa                                         4827


<210>  3
<211>  941
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ala Tyr Leu Gln Trp Arg Arg Phe Val Phe Phe Asp Lys Glu 
1               5                   10                  15      


Leu Val Lys Glu Pro Leu Ser Asn Asp Gly Ala Ala Pro Gly Ala Thr 
            20                  25                  30          


Pro Ala Ser Gly Ser Ala Ala Ser Lys Phe Leu Cys Leu Pro Pro Gly 
        35                  40                  45              


Ile Thr Val Cys Asp Ser Gly Arg Gly Ser Leu Val Phe Gly Asp Met 
    50                  55                  60                  


Glu Gly Gln Ile Trp Phe Leu Pro Arg Ser Leu Gln Leu Thr Gly Phe 
65                  70                  75                  80  


Gln Ala Tyr Lys Leu Arg Val Thr His Leu Tyr Gln Leu Lys Gln His 
                85                  90                  95      


Asn Ile Leu Ala Ser Val Gly Glu Asp Glu Glu Gly Ile Asn Pro Leu 
            100                 105                 110         


Val Lys Ile Trp Asn Leu Glu Lys Arg Asp Gly Gly Asn Pro Leu Cys 
        115                 120                 125             


Thr Arg Ile Phe Pro Ala Ile Pro Gly Thr Glu Pro Thr Val Val Ser 
    130                 135                 140                 


Cys Leu Thr Val His Glu Asn Leu Asn Phe Met Ala Ile Gly Phe Thr 
145                 150                 155                 160 


Asp Gly Ser Val Thr Leu Asn Lys Gly Asp Ile Thr Arg Asp Arg His 
                165                 170                 175     


Ser Lys Thr Gln Ile Leu His Lys Gly Asn Tyr Pro Val Thr Gly Leu 
            180                 185                 190         


Ala Phe Arg Gln Ala Gly Lys Thr Thr His Leu Phe Val Val Thr Thr 
        195                 200                 205             


Glu Asn Val Gln Ser Tyr Ile Val Ser Gly Lys Asp Tyr Pro Arg Val 
    210                 215                 220                 


Glu Leu Asp Thr His Gly Cys Gly Leu Arg Cys Ser Ala Leu Ser Asp 
225                 230                 235                 240 


Pro Ser Gln Asp Leu Gln Phe Ile Val Ala Gly Asp Glu Cys Val Tyr 
                245                 250                 255     


Leu Tyr Gln Pro Asp Glu Arg Gly Pro Cys Phe Ala Phe Glu Gly His 
            260                 265                 270         


Lys Leu Ile Ala His Trp Phe Arg Gly Tyr Leu Ile Ile Val Ser Arg 
        275                 280                 285             


Asp Arg Lys Val Ser Pro Lys Ser Glu Phe Thr Ser Arg Asp Ser Gln 
    290                 295                 300                 


Ser Ser Asp Lys Gln Ile Leu Asn Ile Tyr Asp Leu Cys Asn Lys Phe 
305                 310                 315                 320 


Ile Ala Tyr Ser Thr Val Phe Glu Asp Val Val Asp Val Leu Ala Glu 
                325                 330                 335     


Trp Gly Ser Leu Tyr Val Leu Thr Arg Asp Gly Arg Val His Ala Leu 
            340                 345                 350         


Gln Glu Lys Asp Thr Gln Thr Lys Leu Glu Met Leu Phe Lys Lys Asn 
        355                 360                 365             


Leu Phe Glu Met Ala Ile Asn Leu Ala Lys Ser Gln His Leu Asp Ser 
    370                 375                 380                 


Asp Gly Leu Ala Gln Ile Phe Met Gln Tyr Gly Asp His Leu Tyr Ser 
385                 390                 395                 400 


Lys Gly Asn His Asp Gly Ala Val Gln Gln Tyr Ile Arg Thr Ile Gly 
                405                 410                 415     


Lys Leu Glu Pro Ser Tyr Val Ile Arg Lys Phe Leu Asp Ala Gln Arg 
            420                 425                 430         


Ile His Asn Leu Thr Ala Tyr Leu Gln Thr Leu His Arg Gln Ser Leu 
        435                 440                 445             


Ala Asn Ala Asp His Thr Thr Leu Leu Leu Asn Cys Tyr Thr Lys Leu 
    450                 455                 460                 


Lys Asp Ser Ser Lys Leu Glu Glu Phe Ile Lys Lys Lys Ser Glu Ser 
465                 470                 475                 480 


Glu Val His Phe Asp Val Glu Thr Ala Ile Lys Val Leu Arg Gln Ala 
                485                 490                 495     


Gly Tyr Tyr Ser His Ala Leu Tyr Leu Ala Glu Asn His Ala His His 
            500                 505                 510         


Glu Trp Tyr Leu Lys Ile Gln Leu Glu Asp Ile Lys Asn Tyr Gln Glu 
        515                 520                 525             


Ala Leu Arg Tyr Ile Gly Lys Leu Pro Phe Glu Gln Ala Glu Ser Asn 
    530                 535                 540                 


Met Lys Arg Tyr Gly Lys Ile Leu Met His His Ile Pro Glu Gln Thr 
545                 550                 555                 560 


Thr Gln Leu Leu Lys Gly Leu Cys Thr Asp Tyr Arg Pro Ser Leu Glu 
                565                 570                 575     


Gly Arg Ser Asp Arg Glu Ala Pro Gly Cys Arg Ala Asn Ser Glu Glu 
            580                 585                 590         


Phe Ile Pro Ile Phe Ala Asn Asn Pro Arg Glu Leu Lys Ala Phe Leu 
        595                 600                 605             


Glu His Met Ser Glu Val Gln Pro Asp Ser Pro Gln Gly Ile Tyr Asp 
    610                 615                 620                 


Thr Leu Leu Glu Leu Arg Leu Gln Asn Trp Ala His Glu Lys Asp Pro 
625                 630                 635                 640 


Gln Val Lys Glu Lys Leu His Ala Glu Ala Ile Ser Leu Leu Lys Ser 
                645                 650                 655     


Gly Arg Phe Cys Asp Val Phe Asp Lys Ala Leu Val Leu Cys Gln Met 
            660                 665                 670         


His Asp Phe Gln Asp Gly Val Leu Tyr Leu Tyr Glu Gln Gly Lys Leu 
        675                 680                 685             


Phe Gln Gln Ile Met His Tyr His Met Gln His Glu Gln Tyr Arg Gln 
    690                 695                 700                 


Val Ile Ser Val Cys Glu Arg His Gly Glu Gln Asp Pro Ser Leu Trp 
705                 710                 715                 720 


Glu Gln Ala Leu Ser Tyr Phe Ala Arg Lys Glu Glu Asp Cys Lys Glu 
                725                 730                 735     


Tyr Val Ala Ala Val Leu Lys His Ile Glu Asn Lys Asn Leu Met Pro 
            740                 745                 750         


Pro Leu Leu Val Val Gln Thr Leu Ala His Asn Ser Thr Ala Thr Leu 
        755                 760                 765             


Ser Val Ile Arg Asp Tyr Leu Val Gln Lys Leu Gln Lys Gln Ser Gln 
    770                 775                 780                 


Gln Ile Ala Gln Asp Glu Leu Arg Val Arg Arg Tyr Arg Glu Glu Thr 
785                 790                 795                 800 


Thr Arg Ile Arg Gln Glu Ile Gln Glu Leu Lys Ala Ser Pro Lys Ile 
                805                 810                 815     


Phe Gln Lys Thr Lys Cys Ser Ile Cys Asn Ser Ala Leu Glu Leu Pro 
            820                 825                 830         


Ser Val His Phe Leu Cys Gly His Ser Phe His Gln His Cys Phe Glu 
        835                 840                 845             


Ser Tyr Ser Glu Ser Asp Ala Asp Cys Pro Thr Cys Leu Pro Glu Asn 
    850                 855                 860                 


Arg Lys Val Met Asp Met Ile Arg Ala Gln Glu Gln Lys Arg Asp Leu 
865                 870                 875                 880 


His Asp Gln Phe Gln His Gln Leu Lys Cys Ser Asn Asp Ser Phe Ser 
                885                 890                 895     


Val Ile Ala Asp Tyr Phe Gly Arg Gly Val Phe Asn Lys Leu Thr Leu 
            900                 905                 910         


Leu Thr Asp Pro Pro Thr Ala Arg Leu Thr Ser Ser Leu Glu Ala Gly 
        915                 920                 925             


Leu Gln Arg Asp Leu Leu Met His Ser Arg Arg Gly Thr 
    930                 935                 940     


<210>  4
<211>  3279
<212>  DNA
<213>  Homo sapiens

<400>  4
ctcacgtgac aaagctcccg gaggtgggag ccctgggcca aaatggcggc ctacctgcag       60

tggcggcgct tcgttttctt cgacaaggag ctggtgaagg agccgctgag caatgatggg      120

gccgctcccg gggccacacc tgcttctgga tccgctgctt ccaagttcct ttgcctccct      180

cctggcatca ctgtctgcga ctcaggccga gggagcctgg tctttggaga tatggaaggc      240

cagatctggt tcttgccacg ttccctacag cttacaggct tccaagccta caaactacgg      300

gtgacacacc tgtaccaact gaagcagcac aatattctgg catctgttgg agaagatgaa      360

gagggcatca accccttggt taagatctgg aacctggaga agagagatgg tggcaatcca      420

ctctgcactc gaatcttccc tgctattcca ggaacagagc caactgttgt atcttgtttg      480

actgtccatg aaaatctcaa ctttatggcc attggtttca cagatggcag tgttacattg      540

aacaaaggag acatcacccg ggaccggcat agcaagaccc agattttgca caagggcaac      600

tatcctgtaa ctggattggc ctttcgccaa gcaggaaaga ccactcactt gtttgttgtg      660

acaacagaga acgtccagtc ctatatagtt tctggaaaag actaccctcg cgtggagttg      720

gacacccatg gttgtggcct gcgctgctca gccctaagtg acccttctca ggacctgcag      780

ttcattgtgg ccggggatga gtgtgtctac ttgtaccagc ctgatgaacg tgggccctgc      840

ttcgcctttg agggccataa gctcattgcc cactggttta gaggctacct tatcattgtc      900

tcccgtgacc ggaaggtttc tcccaagtca gagtttacca gcagggattc acagagctcc      960

gacaagcaga ttctaaacat ctatgacctg tgcaacaagt tcatagccta tagcaccgtc     1020

tttgaggatg tagtggatgt gcttgctgag tggggctccc tgtacgtgct gacgcgggat     1080

gggcgggtcc acgcactgca ggagaaggac acacagacca aactggagat gctgtttaag     1140

aagaacctat ttgagatggc gattaacctt gccaagagcc agcatctgga cagtgatggg     1200

ctggcccaga ttttcatgca gtatggagac catctctaca gcaagggcaa ccacgatggg     1260

gctgtccagc aatatatccg aaccattgga aagttggagc catcctacgt gatccgcaag     1320

tttctggatg cccagcgcat tcacaacctg actgcctacc tgcagaccct gcaccgacaa     1380

tccctggcca atgccgacca taccaccctg ctcctcaact gctataccaa gctcaaggac     1440

agctcgaagc tggaggagtt catcaagaaa aagagtgaga gtgaagtcca ctttgatgtg     1500

gagacagcca tcaaggtcct ccggcaggct ggctactact cccatgccct gtatctggcg     1560

gagaaccatg cacatcatga gtggtacctg aagatccagc tagaagacat taagaattat     1620

caggaagccc ttcgatacat cggcaagctg ccttttgagc aggcagagag caacatgaag     1680

cgctacggca agatcctcat gcaccacata ccagagcaga caactcagtt gctgaaggga     1740

ctttgtactg attatcggcc cagcctcgaa ggccgcagcg atagggaggc cccaggctgc     1800

agggccaact ctgaggagtt catccccatc tttgccaata acccgcgaga gctgaaagcc     1860

ttcctagagc acatgagtga agtgcagcca gactcacccc aggggatcta cgacacactc     1920

cttgagctgc gactgcagaa ctgggcccac gagaaggatc cacaggtcaa agagaagctt     1980

cacgcagagg ccatttccct gctgaagagt ggtcgcttct gcgacgtctt tgacaaggcc     2040

ctggtcctgt gccagatgca cgacttccag gatggtgtcc tttaccttta tgagcagggg     2100

aagctgttcc agcagatcat gcactaccac atgcagcacg agcagtaccg gcaggtcatc     2160

agcgtgtgtg agcgccatgg ggagcaggac ccctccttgt gggagcaggc cctcagctac     2220

ttcgctcgca aggaggagga ctgcaaggag tatgtggcag ctgtcctcaa gcatatcgag     2280

aacaagaacc tcatgccacc tcttctagtg gtgcagaccc tggcccacaa ctccacagcc     2340

acactctccg tcatcaggga ctacctggtc caaaaactac agaaacagag ccagcagatt     2400

gcacaggatg agctgcgggt gcggcggtac cgagaggaga ccacccgtat ccgccaggag     2460

atccaagagc tcaaggccag tcctaagatt ttccaaaaga ccaagtgcag catctgtaac     2520

agtgccttgg agttgccctc agtccacttc ctgtgtggcc actccttcca ccaacactgc     2580

tttgagagtt actcggaaag tgatgctgac tgccccacct gcctccctga aaaccggaag     2640

gtcatggata tgatccgggc ccaggaacag aaacgagatc tccatgatca attccagcat     2700

cagctcaagt gctccaatga cagcttttct gtgattgctg actactttgg cagaggtgtt     2760

ttcaacaaat tgactctgct gaccgaccct cccacagcca gactgacctc cagcctggag     2820

gctgggctgc aacgcgacct actcatgcac tccaggaggg gcacttaagc agcctggagg     2880

aagatgtggg caacagtgga ggaccaagag aacagacaca atgggacctg ggcgggcgtt     2940

acacagaagg ctggctgaca tgcccagggc tccactctca tctaatgtca cagccctcag     3000

aactaaagcg gactttcttt ccctgccttc ttatttagtc agcttgccat ccctcctctt     3060

cactagcagt gtagatcatt ccagatcagt gggggagggc acctcagcaa cctctgagtg     3120

tggacaatag ctgctttctt ctctatccaa gagcaccagg ctgtgcttgg gtccttgctc     3180

tcagagtcta taaataaaag aatataatga tttgggagct taaaaaaaaa aaaaaaaaaa     3240

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                            3279


<210>  5
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Cys Tyr Thr Ala Asn Trp Asn Pro Leu Gly Asp Ser Ala Phe 
1               5                   10                  15      


Tyr Arg Lys Tyr Glu Leu Tyr Ser Met Asp Trp Asp Leu Lys Glu Glu 
            20                  25                  30          


Leu Arg Asp Cys Leu Val Ala Ala Ala Pro Tyr Gly Gly Pro Ile Ala 
        35                  40                  45              


Leu Leu Arg Asn Pro Trp Arg Lys Glu Lys Ala Ala Ser Val Arg Pro 
    50                  55                  60                  


Val Leu Asp Ile Tyr Ser Ala Ser Gly Met Pro Leu Ala Ser Leu Leu 
65                  70                  75                  80  


Trp Lys Ser Gly Pro Val Val Ser Leu Gly Trp Ser Ala Glu Glu Glu 
                85                  90                  95      


Leu Leu Cys Val Gln Glu Asp Gly Ala Val Leu Val Tyr Gly Leu His 
            100                 105                 110         


Gly Asp Phe Arg Arg His Phe Ser Met Gly Asn Glu Val Leu Gln Asn 
        115                 120                 125             


Arg Val Leu Asp Ala Arg Ile Phe His Thr Glu Phe Gly Ser Gly Val 
    130                 135                 140                 


Ala Ile Leu Thr Gly Ala His Arg Phe Thr Leu Ser Ala Asn Val Gly 
145                 150                 155                 160 


Asp Leu Lys Leu Arg Arg Met Pro Glu Val Pro Gly Leu Gln Ser Ala 
                165                 170                 175     


Pro Ser Cys Trp Thr Val Leu Cys Gln Asp Arg Val Ala His Ile Leu 
            180                 185                 190         


Leu Ala Val Gly Pro Asp Leu Tyr Leu Leu Asp His Ala Ala Cys Ser 
        195                 200                 205             


Ala Val Thr Pro Pro Gly Leu Ala Pro Gly Val Ser Ser Phe Leu Gln 
    210                 215                 220                 


Met Ala Val Ser Phe Thr Tyr Arg His Leu Ala Leu Phe Thr Asp Thr 
225                 230                 235                 240 


Gly Tyr Ile Trp Met Gly Thr Ala Ser Leu Lys Glu Lys Leu Cys Glu 
                245                 250                 255     


Phe Asn Cys Asn Ile Arg Ala Pro Pro Lys Gln Met Val Trp Cys Ser 
            260                 265                 270         


Arg Pro Arg Ser Lys Glu Arg Ala Val Val Val Ala Trp Glu Arg Arg 
        275                 280                 285             


Leu Met Val Val Gly Asp Ala Pro Glu Ser Ile Gln Phe Val Leu Asp 
    290                 295                 300                 


Glu Asp Ser Tyr Leu Val Pro Glu Leu Asp Gly Val Arg Ile Phe Ser 
305                 310                 315                 320 


Arg Ser Thr His Glu Phe Leu His Glu Val Pro Ala Ala Ser Glu Glu 
                325                 330                 335     


Ile Phe Lys Ile Ala Ser Met Ala Pro Gly Ala Leu Leu Leu Glu Ala 
            340                 345                 350         


Gln Lys Glu Tyr Glu Lys Glu Ser Gln Lys Ala Asp Glu Tyr Leu Arg 
        355                 360                 365             


Glu Ile Gln Glu Leu Gly Gln Leu Thr Gln Ala Val Gln Gln Cys Ile 
    370                 375                 380                 


Glu Ala Ala Gly His Glu His Gln Pro Asp Met Gln Lys Ser Leu Leu 
385                 390                 395                 400 


Arg Ala Ala Ser Phe Gly Lys Cys Phe Leu Asp Arg Phe Pro Pro Asp 
                405                 410                 415     


Ser Phe Val His Met Cys Gln Asp Leu Arg Val Leu Asn Ala Val Arg 
            420                 425                 430         


Asp Tyr His Ile Gly Ile Pro Leu Thr Tyr Ser Gln Tyr Lys Gln Leu 
        435                 440                 445             


Thr Ile Gln Val Leu Leu Asp Arg Leu Val Leu Arg Arg Leu Tyr Pro 
    450                 455                 460                 


Leu Ala Ile Gln Ile Cys Glu Tyr Leu Arg Leu Pro Glu Val Gln Gly 
465                 470                 475                 480 


Val Ser Arg Ile Leu Ala His Trp Ala Cys Tyr Lys Val Gln Gln Lys 
                485                 490                 495     


Asp Val Ser Asp Glu Asp Val Ala Arg Ala Ile Asn Gln Lys Leu Gly 
            500                 505                 510         


Asp Thr Pro Gly Val Ser Tyr Ser Asp Ile Ala Ala Arg Ala Tyr Gly 
        515                 520                 525             


Cys Gly Arg Thr Glu Leu Ala Ile Lys Leu Leu Glu Tyr Glu Pro Arg 
    530                 535                 540                 


Ser Gly Glu Gln Val Pro Leu Leu Leu Lys Met Lys Arg Ser Lys Leu 
545                 550                 555                 560 


Ala Leu Ser Lys Ala Ile Glu Ser Gly Asp Thr Asp Leu Val Phe Thr 
                565                 570                 575     


Val Leu Leu His Leu Lys Asn Glu Leu Asn Arg Gly Asp Phe Phe Met 
            580                 585                 590         


Thr Leu Arg Asn Gln Pro Met Ala Leu Ser Leu Tyr Arg Gln Phe Cys 
        595                 600                 605             


Lys His Gln Glu Leu Glu Thr Leu Lys Asp Leu Tyr Asn Gln Asp Asp 
    610                 615                 620                 


Asn His Gln Glu Leu Gly Ser Phe His Ile Arg Ala Ser Tyr Ala Ala 
625                 630                 635                 640 


Glu Glu Arg Ile Glu Gly Arg Val Ala Ala Leu Gln Thr Ala Ala Asp 
                645                 650                 655     


Ala Phe Tyr Lys Ala Lys Asn Glu Phe Ala Ala Lys Ala Thr Glu Asp 
            660                 665                 670         


Gln Met Arg Leu Leu Arg Leu Gln Arg Arg Leu Glu Asp Glu Leu Gly 
        675                 680                 685             


Gly Gln Phe Leu Asp Leu Ser Leu His Asp Thr Val Thr Thr Leu Ile 
    690                 695                 700                 


Leu Gly Gly His Asn Lys Arg Ala Glu Gln Leu Ala Arg Asp Phe Arg 
705                 710                 715                 720 


Ile Pro Asp Lys Arg Leu Trp Trp Leu Lys Leu Thr Ala Leu Ala Asp 
                725                 730                 735     


Leu Glu Asp Trp Glu Glu Leu Glu Lys Phe Ser Lys Ser Lys Lys Ser 
            740                 745                 750         


Pro Ile Gly Tyr Leu Pro Phe Val Glu Ile Cys Met Lys Gln His Asn 
        755                 760                 765             


Lys Tyr Glu Ala Lys Lys Tyr Ala Ser Arg Val Gly Pro Glu Gln Lys 
    770                 775                 780                 


Val Lys Ala Leu Leu Leu Val Gly Asp Val Ala Gln Ala Ala Asp Val 
785                 790                 795                 800 


Ala Ile Glu His Arg Asn Glu Ala Glu Leu Ser Leu Val Leu Ser His 
                805                 810                 815     


Cys Thr Gly Ala Thr Asp Gly Ala Thr Ala Asp Lys Ile Gln Arg Ala 
            820                 825                 830         


Arg Ala Gln Ala Gln Lys Lys 
        835                 


<210>  6
<211>  2769
<212>  DNA
<213>  Homo sapiens

<400>  6
ctaggtgggt gtcccctcgg tgcttcccag ctgccgtctg caccagccat ggactgctac       60

acggcgaact ggaacccact cggggactct gccttttacc ggaaatatga gctgtacagc      120

atggactggg acctgaagga ggaactcagg gattgcctgg tggctgctgc accctatggg      180

ggccccattg cactgctgag gaacccctgg cggaaggaga aagctgctag tgtgaggcca      240

gtgctcgata tatactctgc ttccggcatg cctctggcca gcctgctgtg gaagagtgga      300

cccgtggtgt ccctgggctg gtcagctgag gaggagctgc tctgtgtgca ggaagatggt      360

gctgtactgg tttatgggct tcatggtgac ttccggagac acttcagcat gggcaatgaa      420

gtgctccaga accgggttct ggatgcccgg atctttcaca ctgagtttgg ttccggagtg      480

gccatcctca caggggccca ccgcttcacc ctcagtgcca atgtgggtga cctcaaactc      540

cgccggatgc cagaggtgcc aggtctgcaa agtgcaccct cctgctggac tgtgctgtgc      600

caggaccgag tggcacacat tcttctggct gtggggcctg acctttacct cttggaccat      660

gcagcctgct ccgcagtgac gccccctggc ctggccccag gagtaagcag cttcctacag      720

atggctgtct ccttcaccta ccgacacctg gcactcttca cagacacagg ctacatctgg      780

atggggacag catcactcaa ggagaagcta tgtgagttca actgcaacat ccgggcacct      840

ccaaagcaga tggtctggtg cagccgtcct cgtagcaagg agagggccgt ggtggtggcc      900

tgggaaaggc ggctgatggt ggtgggcgat gcacccgaga gcatccagtt tgtgctggat      960

gaggactcct acctggtgcc tgagctcgat ggggtccgca tcttctcccg cagcacccac     1020

gagttcctgc atgaggttcc agcggccagc gaggaaatct tcaaaattgc ctcaatggcc     1080

cccggggcgc tgctcctgga ggctcagaag gagtatgaga aagagagcca gaaggcggac     1140

gagtacctgc gggagatcca ggagctgggc cagctgaccc aggccgtgca gcagtgcatt     1200

gaggctgcag gacatgagca ccagccagac atgcagaaga gtctgctcag ggccgcctcc     1260

ttcggaaagt gtttcctgga cagatttcca cccgacagct tcgtgcacat gtgtcaggac     1320

ctgcgtgtgc tcaatgctgt tcgggactat cacatcggga tcccgctcac ctatagccaa     1380

tataagcagc tcaccatcca ggtgctgctg gacaggctcg tgttgcggag actttacccc     1440

ctggccatcc agatatgcga gtacttgcgc cttcctgaag tacagggcgt cagcaggatc     1500

ctggcccact gggcctgcta caaggtgcaa cagaaggatg tctcagatga ggatgtggct     1560

cgagccatta accagaagct gggggacacg cctggtgtct cttactccga cattgctgca     1620

cgagcctatg gttgtggccg cacggagctg gccatcaagc tgctggagta tgagccacgc     1680

tcaggggagc aggtacccct tctcctaaag atgaagagga gcaaactggc actaagcaag     1740

gccatcgaga gcggggacac tgacctggtg ttcacggtgt tgctgcacct gaagaacgag     1800

ctgaaccgag gagatttttt catgaccctt cggaatcagc ccatggccct cagtttgtac     1860

cgacagttct gtaagcatca ggagctagag acgctgaagg acctttacaa tcaggatgac     1920

aatcaccagg aattgggcag cttccacatc cgagccagct atgctgcaga agagcgtatt     1980

gaggggcgag tagcagctct gcagacagcc gccgatgcct tctacaaggc caagaatgag     2040

tttgcagcca aggctacaga ggatcaaatg cggctcctac ggctgcagcg gcgcctagaa     2100

gacgagctgg ggggccagtt cctagacctg tctctacatg acacagttac caccctcatt     2160

cttggcggtc acaacaagcg tgcagagcag ctggcacgtg acttccgcat ccctgacaag     2220

aggctctggt ggctgaagct gactgccctg gcagatttgg aagattggga agagctagag     2280

aagttttcca agagcaagaa atcacccatt ggctacctgc cttttgtgga gatctgcatg     2340

aaacaacata acaaatacga agccaagaag tatgcttccc gcgtgggtcc cgagcagaag     2400

gtcaaggctt tgcttcttgt tggcgatgtg gctcaggctg cagatgtggc catcgaacac     2460

cggaatgagg ctgagctgag cctcgtattg tcccactgca cgggagccac agatggggcc     2520

acagctgaca agattcaacg ggccagggca caagcccaga agaagtgagg agtccatcct     2580

gtacatctca agcaaggggt tcctccccta gcacctgggc ttggcagaag ggccatagtt     2640

catccagctc ctcccctaga gcaatgctga ggagcggggg catggtagca gggctgtctg     2700

gttttaaata aagttggaac acttcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2760

aaaaaaaaa                                                             2769


<210>  7
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Ser Ile Leu Asp Glu Tyr Glu Asn Ser Leu Ser Arg Ser Ala 
1               5                   10                  15      


Val Leu Gln Pro Gly Cys Pro Ser Val Gly Ile Pro His Ser Gly Tyr 
            20                  25                  30          


Val Asn Ala Gln Leu Glu Lys Glu Val Pro Ile Phe Thr Lys Gln Arg 
        35                  40                  45              


Ile Asp Phe Thr Pro Ser Glu Arg Ile Thr Ser Leu Val Val Ser Ser 
    50                  55                  60                  


Asn Gln Leu Cys Met Ser Leu Gly Lys Asp Thr Leu Leu Arg Ile Asp 
65                  70                  75                  80  


Leu Gly Lys Ala Asn Glu Pro Asn His Val Glu Leu Gly Arg Lys Asp 
                85                  90                  95      


Asp Ala Lys Val His Lys Met Phe Leu Asp His Thr Gly Ser His Leu 
            100                 105                 110         


Leu Ile Ala Leu Ser Ser Thr Glu Val Leu Tyr Val Asn Arg Asn Gly 
        115                 120                 125             


Gln Lys Val Arg Pro Leu Ala Arg Trp Lys Gly Gln Leu Val Glu Ser 
    130                 135                 140                 


Val Gly Trp Asn Lys Ala Leu Gly Thr Glu Ser Ser Thr Gly Pro Ile 
145                 150                 155                 160 


Leu Val Gly Thr Ala Gln Gly His Ile Phe Glu Ala Glu Leu Ser Ala 
                165                 170                 175     


Ser Glu Gly Gly Leu Phe Gly Pro Ala Pro Asp Leu Tyr Phe Arg Pro 
            180                 185                 190         


Leu Tyr Val Leu Asn Glu Glu Gly Gly Pro Ala Pro Val Cys Ser Leu 
        195                 200                 205             


Glu Ala Glu Arg Gly Pro Asp Gly Arg Ser Phe Val Ile Ala Thr Thr 
    210                 215                 220                 


Arg Gln Arg Leu Phe Gln Phe Ile Gly Arg Ala Ala Glu Gly Ala Glu 
225                 230                 235                 240 


Ala Gln Gly Phe Ser Gly Leu Phe Ala Ala Tyr Thr Asp His Pro Pro 
                245                 250                 255     


Pro Phe Arg Glu Phe Pro Ser Asn Leu Gly Tyr Ser Glu Leu Ala Phe 
            260                 265                 270         


Tyr Thr Pro Lys Leu Arg Ser Ala Pro Arg Ala Phe Ala Trp Met Met 
        275                 280                 285             


Gly Asp Gly Val Leu Tyr Gly Ala Leu Asp Cys Gly Arg Pro Asp Ser 
    290                 295                 300                 


Leu Leu Ser Glu Glu Arg Val Trp Glu Tyr Pro Glu Gly Val Gly Pro 
305                 310                 315                 320 


Gly Ala Ser Pro Pro Leu Ala Ile Val Leu Thr Gln Phe His Phe Leu 
                325                 330                 335     


Leu Leu Leu Ala Asp Arg Val Glu Ala Val Cys Thr Leu Thr Gly Gln 
            340                 345                 350         


Val Val Leu Arg Asp His Phe Leu Glu Lys Phe Gly Pro Leu Lys His 
        355                 360                 365             


Met Val Lys Asp Ser Ser Thr Gly Gln Leu Trp Ala Tyr Thr Glu Arg 
    370                 375                 380                 


Ala Val Phe Arg Tyr His Val Gln Arg Glu Ala Arg Asp Val Trp Arg 
385                 390                 395                 400 


Thr Tyr Leu Asp Met Asn Arg Phe Asp Leu Ala Lys Glu Tyr Cys Arg 
                405                 410                 415     


Glu Arg Pro Asp Cys Leu Asp Thr Val Leu Ala Arg Glu Ala Asp Phe 
            420                 425                 430         


Cys Phe Arg Gln Arg Arg Tyr Leu Glu Ser Ala Arg Cys Tyr Ala Leu 
        435                 440                 445             


Thr Gln Ser Tyr Phe Glu Glu Ile Ala Leu Lys Phe Leu Glu Ala Arg 
    450                 455                 460                 


Gln Glu Glu Ala Leu Ala Glu Phe Leu Gln Arg Lys Leu Ala Ser Leu 
465                 470                 475                 480 


Lys Pro Ala Glu Arg Thr Gln Ala Thr Leu Leu Thr Thr Trp Leu Thr 
                485                 490                 495     


Glu Leu Tyr Leu Ser Arg Leu Gly Ala Leu Gln Gly Asp Pro Glu Ala 
            500                 505                 510         


Leu Thr Leu Tyr Arg Glu Thr Lys Glu Cys Phe Arg Thr Phe Leu Ser 
        515                 520                 525             


Ser Pro Arg His Lys Glu Trp Leu Phe Ala Ser Arg Ala Ser Ile His 
    530                 535                 540                 


Glu Leu Leu Ala Ser His Gly Asp Thr Glu His Met Val Tyr Phe Ala 
545                 550                 555                 560 


Val Ile Met Gln Asp Tyr Glu Arg Val Val Ala Tyr His Cys Gln His 
                565                 570                 575     


Glu Ala Tyr Glu Glu Ala Leu Ala Val Leu Ala Arg His Arg Asp Pro 
            580                 585                 590         


Gln Leu Phe Tyr Lys Phe Ser Pro Ile Leu Ile Arg His Ile Pro Arg 
        595                 600                 605             


Gln Leu Val Asp Ala Trp Ile Glu Met Gly Ser Arg Leu Asp Ala Arg 
    610                 615                 620                 


Gln Leu Ile Pro Ala Leu Val Asn Tyr Ser Gln Gly Gly Glu Val Gln 
625                 630                 635                 640 


Gln Val Ser Gln Ala Ile Arg Tyr Met Glu Phe Cys Val Asn Val Leu 
                645                 650                 655     


Gly Glu Thr Glu Gln Ala Ile His Asn Tyr Leu Leu Ser Leu Tyr Ala 
            660                 665                 670         


Arg Gly Arg Pro Asp Ser Leu Leu Ala Tyr Leu Glu Gln Ala Gly Ala 
        675                 680                 685             


Ser Pro His Arg Val His Tyr Asp Leu Lys Tyr Ala Leu Arg Leu Cys 
    690                 695                 700                 


Ala Glu His Gly His His Arg Ala Cys Val His Val Tyr Lys Val Leu 
705                 710                 715                 720 


Glu Leu Tyr Glu Glu Ala Val Asp Leu Ala Leu Gln Val Asp Val Asp 
                725                 730                 735     


Leu Ala Lys Gln Cys Ala Asp Leu Pro Glu Glu Asp Glu Glu Leu Arg 
            740                 745                 750         


Lys Lys Leu Trp Leu Lys Ile Ala Arg His Val Val Gln Glu Glu Glu 
        755                 760                 765             


Asp Val Gln Thr Ala Met Ala Cys Leu Ala Ser Cys Pro Leu Leu Lys 
    770                 775                 780                 


Ile Glu Asp Val Leu Pro Phe Phe Pro Asp Phe Val Thr Ile Asp His 
785                 790                 795                 800 


Phe Lys Glu Ala Ile Cys Ser Ser Leu Lys Ala Tyr Asn His His Ile 
                805                 810                 815     


Gln Glu Leu Gln Arg Glu Met Glu Glu Ala Thr Ala Ser Ala Gln Arg 
            820                 825                 830         


Ile Arg Arg Asp Leu Gln Glu Leu Arg Gly Arg Tyr Gly Thr Val Glu 
        835                 840                 845             


Pro Gln Asp Lys Cys Ala Thr Cys Asp Phe Pro Leu Leu Asn Arg Pro 
    850                 855                 860                 


Phe Tyr Leu Phe Leu Cys Gly His Met Phe His Ala Asp Cys Leu Leu 
865                 870                 875                 880 


Gln Ala Val Arg Pro Gly Leu Pro Ala Tyr Lys Gln Ala Arg Leu Glu 
                885                 890                 895     


Glu Leu Gln Arg Lys Leu Gly Ala Ala Pro Pro Pro Ala Lys Gly Ser 
            900                 905                 910         


Ala Arg Ala Lys Glu Ala Glu Gly Gly Ala Ala Thr Ala Gly Pro Ser 
        915                 920                 925             


Arg Glu Gln Leu Lys Ala Asp Leu Asp Glu Leu Val Ala Ala Glu Cys 
    930                 935                 940                 


Val Tyr Cys Gly Glu Leu Met Ile Arg Ser Ile Asp Arg Pro Phe Ile 
945                 950                 955                 960 


Asp Pro Gln Arg Tyr Glu Glu Glu Gln Leu Ser Trp Leu 
                965                 970             


<210>  8
<211>  3922
<212>  DNA
<213>  Homo sapiens

<400>  8
gcccgcgtca cgggggcggg agtcagctga gctgccgggg cgaggttggg atcacctggc       60

accggctgaa gggagcctgt gatttttttg tagcgggggc ggggagtaag gtgcaagact      120

gcgccagatt caaggacgag ggctgcccga ttatctcgct gcataaggca agagcaagag      180

gatcctcagg attttaaaga ggaggcgacg gctgcaggtt cccaggatct gtcagaggct      240

ggggagttac agcttccatt ctggggcgac ggggaccccg ggggggtagc ccttttgtaa      300

tccccaggcc ccggacaaag agcccagagg ccgggcacca tggcgtccat cctggatgag      360

tacgagaact cgctgtcccg ctcggccgtc ttgcagcccg gctgccctag cgtgggcatc      420

ccccactcgg ggtatgtgaa tgcccagctg gagaaggaag tgcccatctt cacaaagcag      480

cgcattgact tcaccccttc cgagcgcatt accagtcttg tcgtctccag caatcagctg      540

tgcatgagcc tgggcaagga tacactgctc cgcattgact tgggcaaggc aaatgagccc      600

aaccacgtgg agctgggacg taaggatgac gcaaaagttc acaagatgtt ccttgaccat      660

actggctctc acctgctgat tgccctgagc agcacggagg tcctctacgt gaaccgaaat      720

ggacagaagg tacggccact agcacgctgg aaggggcagc tggtggagag tgtgggttgg      780

aacaaggcac tgggcacgga gagcagcaca ggccccatcc tggtcgggac tgcccaaggc      840

cacatctttg aagcagagct ctcagccagc gaaggtgggc ttttcggccc tgctccggat      900

ctctacttcc gcccattgta cgtgctaaat gaagaagggg gtccagcacc tgtgtgctcc      960

cttgaggccg agcggggccc tgatgggcgt agctttgtta ttgccaccac tcggcagcgc     1020

ctcttccagt tcataggccg agcagcagag ggggctgagg cccagggttt ctcagggctc     1080

tttgcagctt acacggacca cccaccccca ttccgtgagt ttcccagcaa cctgggctac     1140

agtgagttgg ccttctacac ccccaagctg cgctccgcac cccgggcctt cgcctggatg     1200

atgggggatg gtgtgttgta tggggcattg gactgtgggc gccctgactc tctgctgagc     1260

gaggagcgag tctgggagta cccagagggg gtagggcctg gggccagccc acccctagcc     1320

atcgtcttga cccagttcca cttcctgctg ctactggcag accgggtgga ggcagtgtgc     1380

acactgaccg ggcaggtggt gctgcgggat cacttcctgg agaaatttgg gccgctgaag     1440

cacatggtga aggactcctc cacaggccag ctgtgggcct acactgagcg ggctgtcttc     1500

cgctaccacg tgcaacggga ggcccgagat gtctggcgca cctatctgga catgaaccgc     1560

ttcgatctgg ccaaagagta ttgtcgagag cggcccgact gcctggacac ggtcctggcc     1620

cgggaggccg atttctgctt tcgccagcgt cgctacctgg agagcgcacg ctgctatgcc     1680

ctgacccaga gctactttga ggagattgcc ctcaagttcc tggaggcccg acaggaggag     1740

gctctggctg agttcctgca gcgaaaactg gccagtttga agccagccga acgtacccag     1800

gccacactgc tgaccacctg gctgacagag ctctacctga gccggcttgg ggctctgcag     1860

ggcgacccag aggccctgac tctctaccga gaaaccaagg aatgctttcg aaccttcctc     1920

agcagccccc gccacaaaga gtggctcttt gccagccggg cctctatcca tgagctgctc     1980

gccagtcatg gggacacaga acacatggtg tactttgcag tgatcatgca ggactatgag     2040

cgggtggtgg cttaccactg tcagcacgag gcctacgagg aggccctggc cgtgctcgcc     2100

cgccaccgtg acccccagct cttctacaag ttctcaccca tcctcatccg tcacatcccc     2160

cgccagcttg tagatgcctg gattgagatg ggcagccggc tggatgctcg tcagctcatt     2220

cctgccctgg tgaactacag ccagggtggt gaggtccagc aggtgagcca ggccatccgc     2280

tacatggagt tctgcgtgaa cgtgctgggg gagactgagc aggccatcca caactacctg     2340

ctgtcactgt atgcccgtgg ccggccggac tcactactgg cctatctgga gcaggctggg     2400

gccagccccc accgggtgca ttacgacctc aagtatgcgc tgcggctctg cgccgagcat     2460

ggccaccacc gcgcttgtgt ccatgtctac aaggtcctag agctgtatga ggaggccgtg     2520

gacctggccc tgcaggtgga tgtggacctg gccaagcagt gtgcagacct gcctgaggag     2580

gatgaggaat tgcgcaagaa gctgtggctg aagatcgcac ggcacgtggt gcaggaagag     2640

gaagatgtac agacagccat ggcttgcctg gctagctgcc ccttgctcaa gattgaggat     2700

gtgctgccct tctttcctga tttcgtcacc atcgaccact tcaaggaggc gatctgcagc     2760

tcacttaagg cctacaacca ccacatccag gagctgcagc gggagatgga agaggctaca     2820

gccagtgccc agcgcatccg gcgagacctg caggagctgc ggggccgcta cggcactgtg     2880

gagccccagg acaaatgtgc cacctgcgac ttccccctgc tcaaccgccc tttttacctc     2940

ttcctctgtg gccatatgtt ccatgctgac tgcctgctgc aggctgtgcg acctggcctg     3000

ccagcctaca agcaggcccg gctggaggag ctgcagagga agctgggggc tgctccaccc     3060

ccagccaagg gctctgcccg ggccaaggag gccgagggtg gggctgccac ggcagggccc     3120

agccgggaac agctcaaggc tgacctggat gagttggtgg ccgctgagtg tgtgtactgt     3180

ggggagctga tgatccgctc tatcgaccgg ccgttcatcg acccccagcg ctacgaggag     3240

gagcagctca gttggctgta ggagggtgtc acctttgatg gggggtgggc aatggggagc     3300

agtggcttga acccacttga gaaggctgcc tcctaggctc tgctcagtca tcttgcaatt     3360

gccacactgt gaccacgttg acgggagtag agtagcgctg ttggccagga ggtgtcaggt     3420

gtgagtgtat tctgccagct tttcatgctg ttcttcagag ctgcagttat gccagaccat     3480

cagcctgcct cccagtagag gcccttcacc tggagaagtc agaaatctga cccaattcca     3540

ccccctgcct ctagcacctc ttctgtccct gtcattcccc acacacgtcc tgttcacctc     3600

gagagagaga gagagagagc acctttcttc cgtctgttca ctctgcggcc tctggaatcc     3660

cagctcttct ctctcagaag aagccttctc ttcctcctgc ctgtaggtgt cccagaagtg     3720

agaaggcagc cttcgaagtc ctgggcattg ggtgagaaag tgatgctagt tggggcatgc     3780

ttttgtgcac actctctggg gctccagtgt gaagggtgcc ctggggctga gggccttgtg     3840

gaggatggtc ggtggtggtg atggaggtgg agagcattaa actgtctgca ctgcaaaaaa     3900

aaaaaaaaaa aaaaaaaaaa aa                                              3922


<210>  9
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ala His Leu Ser Tyr Gly Arg Val Asn Leu Asn Val Leu Arg 
1               5                   10                  15      


Glu Ala Val Arg Arg Glu Leu Arg Glu Phe Leu Asp Lys Cys Ala Gly 
            20                  25                  30          


Ser Lys Ala Ile Val Trp Asp Glu Tyr Leu Thr Gly Pro Phe Gly Leu 
        35                  40                  45              


Ile Ala Gln Tyr Ser Leu Leu Lys Glu His Glu Val Glu Lys Met Phe 
    50                  55                  60                  


Thr Leu Lys Gly Asn Arg Leu Pro Ala Ala Asp Val Lys Asn Ile Ile 
65                  70                  75                  80  


Phe Phe Val Arg Pro Arg Leu Glu Leu Met Asp Ile Ile Ala Glu Asn 
                85                  90                  95      


Val Leu Ser Glu Asp Arg Arg Gly Pro Thr Arg Asp Phe His Ile Leu 
            100                 105                 110         


Phe Val Pro Arg Arg Ser Leu Leu Cys Glu Gln Arg Leu Lys Asp Leu 
        115                 120                 125             


Gly Val Leu Gly Ser Phe Ile His Arg Glu Glu Tyr Ser Leu Asp Leu 
    130                 135                 140                 


Ile Pro Phe Asp Gly Asp Leu Leu Ser Met Glu Ser Glu Gly Ala Phe 
145                 150                 155                 160 


Lys Glu Cys Tyr Leu Glu Gly Asp Gln Thr Ser Leu Tyr His Ala Ala 
                165                 170                 175     


Lys Gly Leu Met Thr Leu Gln Ala Leu Tyr Gly Thr Ile Pro Gln Ile 
            180                 185                 190         


Phe Gly Lys Gly Glu Cys Ala Arg Gln Val Ala Asn Met Met Ile Arg 
        195                 200                 205             


Met Lys Arg Glu Phe Thr Gly Ser Gln Asn Ser Ile Phe Pro Val Phe 
    210                 215                 220                 


Asp Asn Leu Leu Leu Leu Asp Arg Asn Val Asp Leu Leu Thr Pro Leu 
225                 230                 235                 240 


Ala Thr Gln Leu Thr Tyr Glu Gly Leu Ile Asp Glu Ile Tyr Gly Ile 
                245                 250                 255     


Gln Asn Ser Tyr Val Lys Leu Pro Pro Glu Lys Phe Ala Pro Lys Lys 
            260                 265                 270         


Gln Gly Asp Gly Gly Lys Asp Leu Pro Thr Glu Ala Lys Lys Leu Gln 
        275                 280                 285             


Leu Asn Ser Ala Glu Glu Leu Tyr Ala Glu Ile Arg Asp Lys Asn Phe 
    290                 295                 300                 


Asn Ala Val Gly Ser Val Leu Ser Lys Lys Ala Lys Ile Ile Ser Ala 
305                 310                 315                 320 


Ala Phe Glu Glu Arg His Asn Ala Lys Thr Val Gly Glu Ile Lys Gln 
                325                 330                 335     


Phe Val Ser Gln Leu Pro His Met Gln Ala Ala Arg Gly Ser Leu Ala 
            340                 345                 350         


Asn His Thr Ser Ile Ala Glu Leu Ile Lys Asp Val Thr Thr Ser Glu 
        355                 360                 365             


Asp Phe Phe Asp Lys Leu Thr Val Glu Gln Glu Phe Met Ser Gly Ile 
    370                 375                 380                 


Asp Thr Asp Lys Val Asn Asn Tyr Ile Glu Asp Cys Ile Ala Gln Lys 
385                 390                 395                 400 


His Ser Leu Ile Lys Val Leu Arg Leu Val Cys Leu Gln Ser Val Cys 
                405                 410                 415     


Asn Ser Gly Leu Lys Gln Lys Val Leu Asp Tyr Tyr Lys Arg Glu Ile 
            420                 425                 430         


Leu Gln Thr Tyr Gly Tyr Glu His Ile Leu Thr Leu His Asn Leu Glu 
        435                 440                 445             


Lys Ala Gly Leu Leu Lys Pro Gln Thr Gly Gly Arg Asn Asn Tyr Pro 
    450                 455                 460                 


Thr Ile Arg Lys Thr Leu Arg Leu Trp Met Asp Asp Val Asn Glu Gln 
465                 470                 475                 480 


Asn Pro Thr Asp Ile Ser Tyr Val Tyr Ser Gly Tyr Ala Pro Leu Ser 
                485                 490                 495     


Val Arg Leu Ala Gln Leu Leu Ser Arg Pro Gly Trp Arg Ser Ile Glu 
            500                 505                 510         


Glu Val Leu Arg Ile Leu Pro Gly Pro His Phe Glu Glu Arg Gln Pro 
        515                 520                 525             


Leu Pro Thr Gly Leu Gln Lys Lys Arg Gln Pro Gly Glu Asn Arg Val 
    530                 535                 540                 


Thr Leu Ile Phe Phe Leu Gly Gly Val Thr Phe Ala Glu Ile Ala Ala 
545                 550                 555                 560 


Leu Arg Phe Leu Ser Gln Leu Glu Asp Gly Gly Thr Glu Tyr Val Ile 
                565                 570                 575     


Ala Thr Thr Lys Leu Met Asn Gly Thr Ser Trp Ile Glu Ala Leu Met 
            580                 585                 590         


Glu Lys Pro Phe 
        595     


<210>  10
<211>  2628
<212>  DNA
<213>  Homo sapiens

<400>  10
gtgcgctgcc gtaccggtca cgtggacgtt tggtcacgtg actgcgtccg tggtcctccc       60

gtaggaaccg gcggactcgg ttggcgttgt ggggcagggg gtggtggagc aagatggcgg      120

ctcatctgtc ctacggccga gtgaacctaa acgtgttgcg cgaggcggtg cgtcgcgagc      180

tgcgcgagtt cctggacaag tgcgcaggaa gcaaggcaat agtttgggat gaatacctaa      240

ctggaccctt tggcctgatt gcacagtatt cactattgaa ggaacatgaa gtggaaaaaa      300

tgttcacact taaaggaaat cgtttgccgg cagctgatgt gaagaatata attttttttg      360

tcagacccag gctagagttg atggatataa tcgctgaaaa cgtgctcagt gaagatagac      420

gaggcccaac gagagatttt catattctgt ttgtgccacg ccgtagcctg ttgtgcgaac      480

agcggttgaa ggatctgggt gtcttgggat cctttattca cagggaggag tacagcttag      540

atctcattcc attcgatggg gatctcttat ccatggaatc agagggtgca ttcaaagagt      600

gctacctgga gggtgaccag acgagcctgt accacgcagc caaggggctg atgaccctgc      660

aagctctgta tggaacgatc ccccagatct ttgggaaagg agaatgcgct cggcaagtgg      720

ccaatatgat gatcaggatg aagagagagt ttacaggaag ccagaattca atatttcctg      780

tttttgataa tctcttgttg cttgatcgga atgtggattt attaacacct cttgccactc      840

agctgacata tgaaggactc attgatgaaa tttatggcat tcagaacagt tatgtgaaat      900

tacctccaga gaaatttgca cctaagaaac agggcgatgg tggtaaggac ctccccacgg      960

aagcaaagaa gctgcagctg aattctgcag aggagctcta tgctgagatc cgagataaga     1020

acttcaacgc agttggctct gtgctcagca agaaagcaaa gatcatctct gcagcattcg     1080

aggaaagaca caatgctaag accgtggggg agatcaagca gtttgtttcc cagttgcccc     1140

acatgcaggc agcaaggggc tcgcttgcaa accatacctc aattgcagaa ttgatcaaag     1200

atgtcactac ttctgaagac ttttttgata aattaaccgt ggaacaggag tttatgtctg     1260

gaatagacac tgataaggtc aacaattaca ttgaggattg tatcgcccaa aagcactcgt     1320

tgatcaaggt gttaagacta gtttgcctcc aatccgtgtg taatagtggg ctcaaacaaa     1380

aagttttgga ttattacaaa agagagattc tccagacata cggctatgag cacatattga     1440

ccttacacaa cctggagaag gccggcctgc tgaaaccgca gacggggggc agaaacaatt     1500

acccaactat acggaaaaca ttacgcctct ggatggatga tgttaatgag caaaacccca     1560

cggacatatc gtatgtgtac agtgggtatg ccccgctcag tgtgcggctg gcccagctgc     1620

tttcccggcc tggctggcgg agcatcgagg aggtcctccg catcctccca gggccccact     1680

ttgaggagcg gcagccactg cccacaggac tgcagaagaa acgtcaaccg ggagaaaacc     1740

gagtgactct gatatttttc cttgggggcg taaccttcgc tgaaattgct gccctgcgat     1800

ttctctccca gttggaagat ggaggtacag aatatgtcat tgccaccact aaactaatga     1860

atggaaccag ttggatagag gctctgatgg aaaaaccttt ctaggatgtt cagaggagac     1920

ttaacaagtg tactgcagaa taaactacct ctttgaagaa attgctgaaa ggaagtaaaa     1980

ccccatagaa gaaacatggg aatacagaat atattctggg gtcagcttct taaattatac     2040

tactgtttac tgctttctcc gtctcttttg tattcccttt ttttttttcc tttgagacgg     2100

agtcttgctc tgtcacccag actagagtgc agtggcacgg tctcacctca ctgcaacctc     2160

cacctcctag gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg gactacaggc     2220

atgcaccacc acacccggct aatttttgta tttttagtag ccatggtgtt tcaccatgtt     2280

ggccaggctg gtctcaaact cctgacctca ggtgatccac ctgcctcggc ctcccacagt     2340

gctgggatta caggcctgag ccaccgtgcc tggcccctaa tctgctgaag aaagaagaat     2400

agaagaaaat caacctgagt aaaagcagca ctggttttga gttttctaag ctcagggtct     2460

tcattagaga cctctggaaa tacattaagg atggtggggg tagataatcc attcagccag     2520

acaaacgggg ccagctctta aaataagaaa gctgagactg aggaggtgaa actgaaaata     2580

aaaagagaaa gttcatcctc taaaaaaaaa aaaaaaaaaa aaaaaaaa                  2628


<210>  11
<211>  875
<212>  PRT
<213>  Homo sapiens

<400>  11

Met His Asp Ala Phe Glu Pro Val Pro Ile Leu Glu Lys Leu Pro Leu 
1               5                   10                  15      


Gln Ile Asp Cys Leu Ala Ala Trp Glu Glu Trp Leu Leu Val Gly Thr 
            20                  25                  30          


Lys Gln Gly His Leu Leu Leu Tyr Arg Ile Arg Lys Asp Val Gly Cys 
        35                  40                  45              


Asn Arg Phe Glu Val Thr Leu Glu Lys Ser Asn Lys Asn Phe Ser Lys 
    50                  55                  60                  


Lys Ile Gln Gln Ile His Val Val Ser Gln Phe Lys Ile Leu Val Ser 
65                  70                  75                  80  


Leu Leu Glu Asn Asn Ile Tyr Val His Asp Leu Leu Thr Phe Gln Gln 
                85                  90                  95      


Ile Thr Thr Val Ser Lys Ala Lys Gly Ala Ser Leu Phe Thr Cys Asp 
            100                 105                 110         


Leu Gln His Thr Glu Thr Gly Glu Glu Val Leu Arg Met Cys Val Ala 
        115                 120                 125             


Val Lys Lys Lys Leu Gln Leu Tyr Phe Trp Lys Asp Arg Glu Phe His 
    130                 135                 140                 


Glu Leu Gln Gly Asp Phe Ser Val Pro Asp Val Pro Lys Ser Met Ala 
145                 150                 155                 160 


Trp Cys Glu Asn Ser Ile Cys Val Gly Phe Lys Arg Asp Tyr Tyr Leu 
                165                 170                 175     


Ile Arg Val Asp Gly Lys Gly Ser Ile Lys Glu Leu Phe Pro Thr Gly 
            180                 185                 190         


Lys Gln Leu Glu Pro Leu Val Ala Pro Leu Ala Asp Gly Lys Val Ala 
        195                 200                 205             


Val Gly Gln Asp Asp Leu Thr Val Val Leu Asn Glu Glu Gly Ile Cys 
    210                 215                 220                 


Thr Gln Lys Cys Ala Leu Asn Trp Thr Asp Ile Pro Val Ala Met Glu 
225                 230                 235                 240 


His Gln Pro Pro Tyr Ile Ile Ala Val Leu Pro Arg Tyr Val Glu Ile 
                245                 250                 255     


Arg Thr Phe Glu Pro Arg Leu Leu Val Gln Ser Ile Glu Leu Gln Arg 
            260                 265                 270         


Pro Arg Phe Ile Thr Ser Gly Gly Ser Asn Ile Ile Tyr Val Ala Ser 
        275                 280                 285             


Asn His Phe Val Trp Arg Leu Ile Pro Val Pro Met Ala Thr Gln Ile 
    290                 295                 300                 


Gln Gln Leu Leu Gln Asp Lys Gln Phe Glu Leu Ala Leu Gln Leu Ala 
305                 310                 315                 320 


Glu Met Lys Asp Asp Ser Asp Ser Glu Lys Gln Gln Gln Ile His His 
                325                 330                 335     


Ile Lys Asn Leu Tyr Ala Phe Asn Leu Phe Cys Gln Lys Arg Phe Asp 
            340                 345                 350         


Glu Ser Met Gln Val Phe Ala Lys Leu Gly Thr Asp Pro Thr His Val 
        355                 360                 365             


Met Gly Leu Tyr Pro Asp Leu Leu Pro Thr Asp Tyr Arg Lys Gln Leu 
    370                 375                 380                 


Gln Tyr Pro Asn Pro Leu Pro Val Leu Ser Gly Ala Glu Leu Glu Lys 
385                 390                 395                 400 


Ala His Leu Ala Leu Ile Asp Tyr Leu Thr Gln Lys Arg Ser Gln Leu 
                405                 410                 415     


Val Lys Lys Leu Asn Asp Ser Asp His Gln Ser Ser Thr Ser Pro Leu 
            420                 425                 430         


Met Glu Gly Thr Pro Thr Ile Lys Ser Lys Lys Lys Leu Leu Gln Ile 
        435                 440                 445             


Ile Asp Thr Thr Leu Leu Lys Cys Tyr Leu His Thr Asn Val Ala Leu 
    450                 455                 460                 


Val Ala Pro Leu Leu Arg Leu Glu Asn Asn His Cys His Ile Glu Glu 
465                 470                 475                 480 


Ser Glu His Val Leu Lys Lys Ala His Lys Tyr Ser Glu Leu Ile Ile 
                485                 490                 495     


Leu Tyr Glu Lys Lys Gly Leu His Glu Lys Ala Leu Gln Val Leu Val 
            500                 505                 510         


Asp Gln Ser Lys Lys Ala Asn Ser Pro Leu Lys Gly His Glu Arg Thr 
        515                 520                 525             


Val Gln Tyr Leu Gln His Leu Gly Thr Glu Asn Leu His Leu Ile Phe 
    530                 535                 540                 


Ser Tyr Ser Val Trp Val Leu Arg Asp Phe Pro Glu Asp Gly Leu Lys 
545                 550                 555                 560 


Ile Phe Thr Glu Asp Leu Pro Glu Val Glu Ser Leu Pro Arg Asp Arg 
                565                 570                 575     


Val Leu Gly Phe Leu Ile Glu Asn Phe Lys Gly Leu Ala Ile Pro Tyr 
            580                 585                 590         


Leu Glu His Ile Ile His Val Trp Glu Glu Thr Gly Ser Arg Phe His 
        595                 600                 605             


Asn Cys Leu Ile Gln Leu Tyr Cys Glu Lys Val Gln Gly Leu Met Lys 
    610                 615                 620                 


Glu Tyr Leu Leu Ser Phe Pro Ala Gly Lys Thr Pro Val Pro Ala Gly 
625                 630                 635                 640 


Glu Glu Glu Gly Glu Leu Gly Glu Tyr Arg Gln Lys Leu Leu Met Phe 
                645                 650                 655     


Leu Glu Ile Ser Ser Tyr Tyr Asp Pro Gly Arg Leu Ile Cys Asp Phe 
            660                 665                 670         


Pro Phe Asp Gly Leu Leu Glu Glu Arg Ala Leu Leu Leu Gly Arg Met 
        675                 680                 685             


Gly Lys His Glu Gln Ala Leu Phe Ile Tyr Val His Ile Leu Lys Asp 
    690                 695                 700                 


Thr Arg Met Ala Glu Glu Tyr Cys His Lys His Tyr Asp Arg Asn Lys 
705                 710                 715                 720 


Asp Gly Asn Lys Asp Val Tyr Leu Ser Leu Leu Arg Met Tyr Leu Ser 
                725                 730                 735     


Pro Pro Ser Ile His Cys Leu Gly Pro Ile Lys Leu Glu Leu Leu Glu 
            740                 745                 750         


Pro Lys Ala Asn Leu Gln Ala Ala Leu Gln Val Leu Glu Leu His His 
        755                 760                 765             


Ser Lys Leu Asp Thr Thr Lys Ala Leu Asn Leu Leu Pro Ala Asn Thr 
    770                 775                 780                 


Gln Ile Asn Asp Ile Arg Ile Phe Leu Glu Lys Val Leu Glu Glu Asn 
785                 790                 795                 800 


Ala Gln Lys Lys Arg Phe Asn Gln Val Leu Lys Asn Leu Leu His Ala 
                805                 810                 815     


Glu Phe Leu Arg Val Gln Glu Glu Arg Ile Leu His Gln Gln Val Lys 
            820                 825                 830         


Cys Ile Ile Thr Glu Glu Lys Val Cys Met Val Cys Lys Lys Lys Ile 
        835                 840                 845             


Gly Asn Ser Ala Phe Ala Arg Tyr Pro Asn Gly Val Val Val His Tyr 
    850                 855                 860                 


Phe Cys Ser Lys Glu Val Asn Pro Ala Asp Thr 
865                 870                 875 


<210>  12
<211>  4851
<212>  DNA
<213>  Homo sapiens

<400>  12
ggggttgacg atggctgtgt tgttgaaggg cctgtagccg gggggttcct ggccggatcc       60

cggtctaccc ttagcccaga ctcgttccgg accccagccc ggcccggaac actctgggcg      120

agacggcggt ggcaactctc cccttgccgc catgcacgac gctttcgagc cagtgccgat      180

cctagaaaag ctgcctctgc aaatcgactg tctggctgcc tgggaggaat ggcttcttgt      240

gggaaccaaa caaggacatc ttcttctcta taggattcgg aaggacgttg gttgcaacag      300

atttgaagtg acactagaga aatccaataa gaacttctcc aaaaagattc agcagatcca      360

tgtggtttcc cagtttaaga ttctggtcag cttgttagaa aataacattt atgtccatga      420

cctattgaca tttcaacaaa tcactacggt ttcaaaggca aagggagcat cactgtttac      480

ttgtgacctc cagcacacag agaccggtga ggaggtgtta cggatgtgtg tggcagtaaa      540

aaagaagctg cagctctatt tctggaagga cagggaattt catgaattgc agggggactt      600

tagtgtgcca gatgtgccca agtccatggc gtggtgtgaa aattctatct gtgtgggttt      660

caagagagac tactacctaa taagggtgga tggaaagggg tccatcaaag agctctttcc      720

aacaggaaaa cagctggagc ccttagttgc acctctggca gatggaaaag tggctgtggg      780

ccaggatgat ctcaccgtgg tactcaatga ggaagggatc tgcacacaga aatgtgccct      840

gaactggacg gacataccag tggccatgga gcaccagcct ccctacatca ttgcagtgtt      900

gcctcgatat gttgagatcc gaacatttga accgaggctt ctggtccaaa gcattgaatt      960

gcaaaggccc cgtttcatta cctcaggagg atcaaacatt atctatgtgg ccagcaatca     1020

ttttgtttgg agactcatcc ctgtccccat ggcaacccaa atccaacaac ttctccagga     1080

caagcagttt gaattggctc tgcagctcgc agaaatgaaa gatgattctg acagtgaaaa     1140

gcagcaacaa attcatcaca tcaagaactt gtatgccttc aacctcttct gccagaagcg     1200

ttttgatgag tccatgcagg tctttgctaa acttggcaca gatcccaccc atgtgatggg     1260

cctgtaccct gacctgctgc ccacagacta cagaaagcag ttgcagtatc ccaacccatt     1320

gcctgtgctc tccggggctg aattggagaa ggctcactta gctctgattg actacctgac     1380

acagaaacga agtcaattgg taaagaagct gaatgactct gatcaccagt caagcacctc     1440

accgctcatg gaaggcactc ccaccatcaa atccaagaag aagctgctac aaatcatcga     1500

caccaccctg ctcaagtgct atctccatac aaatgtggcc ctggtggccc ccttgctacg     1560

cctggagaac aatcactgcc acatcgagga gagcgagcac gtgctaaaga aggctcacaa     1620

gtacagtgag cttatcatcc tgtatgagaa gaaggggctc cacgagaaag ctctgcaggt     1680

gctcgtggac cagtccaaga aagccaactc ccctctgaaa ggccacgaga ggacagtgca     1740

gtatctgcag catctgggca cagaaaacct gcatttgatt ttctcctact cagtgtgggt     1800

gctgagagac ttcccagaag atggcctgaa gatatttact gaagatctcc cggaagtgga     1860

gtctctgcca cgtgatcgag tcctcggctt cttaatagag aattttaagg gtctggctat     1920

tccttatctg gaacacatca tccatgtttg ggaggagaca ggctctcggt tccacaactg     1980

cctgatccag ctatactgtg agaaggtgca aggtctgatg aaggagtatc tcctgtcctt     2040

ccctgcaggc aaaaccccag tcccagctgg agaggaagag ggtgagctgg gagaataccg     2100

gcaaaagctc ctcatgttct tggagatttc cagctactat gatccaggcc ggctcatctg     2160

tgattttccc tttgatggcc tcttagaaga acgagctctc ctgttggggc gcatggggaa     2220

acatgaacaa gctcttttca tttatgtcca catcttgaag gatacaagga tggctgagga     2280

gtactgccac aaacactatg accgaaacaa agatggcaac aaagatgtgt atctgtccct     2340

gcttcggatg tacctgtcgc cccccagcat tcactgcctg gggccaatca agctggaact     2400

actggagcca aaagccaacc tccaggccgc tctgcaggtc ctcgagctac accacagcaa     2460

actggacacc accaaggccc tcaaccttct gccagcaaac actcagatca atgacatacg     2520

catcttcctg gaaaaggtct tggaagaaaa tgcacaaaag aaacggttca atcaagtgct     2580

caagaacctt ctccatgcag aattcctgag ggtccaggaa gagcggattt tacaccagca     2640

ggtgaagtgc atcatcacag aggagaaggt gtgcatggtg tgtaagaaga agattgggaa     2700

cagtgcattt gcaagatacc ccaatggagt ggtcgtccat tacttctgtt ccaaagaggt     2760

aaacccagct gacacttgag cccagcatcc tggggatcca gcggatggac agcttggctc     2820

tcccagagag gtgaaggagc acctggcctt aggaatcctg gctgccacca ccacaaggct     2880

ccccatttgg acattactgg ctatcttgtg ccctggaaca actctgaatt aattagactc     2940

atggtctggc attgccagct ttttaatggg aaaagagatt agttatacct tataccatta     3000

tgttgtgggc aattccagag aattcagtac ctgcttggtc aggaggatgt gcaccatctt     3060

gcctttgcac accagtcacc tgaacaagga aacttgtcac aagtgtttgt aaccatgggg     3120

ttgttcatca agggcttttc tattaagtac atgacttcac aaggaccgct cagcatggct     3180

cactggagag ttccatgaga gaacagcact caagcttctg gccgcatgga cccgatggct     3240

cgcattctgt gtagtgtttt acgtctccat ggtaactgtg ccctgcaccc ctcggtagcc     3300

gccctgttag ttttcagtct ccttttcttt ctcaccattt atcacttccc tcactgccct     3360

acccaggctt tctctcccac ttccctgact ctgggaataa ctaatattta agcaaggtaa     3420

gatgagaagc aaggggtctc agttctagga atacagtgct agttgattgt caggtatgtt     3480

gtaaatagac cctctttggc catacactcc atgcctagat gcctcggaga gcatcattct     3540

ctgcctaggc aaggccctgc atcccttgcc tcaggccggg ctgagtgtga ctgcagctcc     3600

tgaggatggg cctgccctgt ctggggtatg cgtgatccct agatacatgt tcccacagag     3660

gtgcctgctc cgtcttcgct caccagacac tcaggcaggc tggcttagtc tttgtgcgtg     3720

gcgattttgt gctctgggcc ctttctcttt ttccagccag tttccattca cttgccttac     3780

agcctgccct ggccgtcact ccccagcttt gttcagcaat ggtgtggttg gagagttgtg     3840

ctgggatagc gcaggaaggt gggtcccggc aacacgcagg ggatgagtgg acctggaact     3900

gacaatggcg tgctgccaag tgttcctgag aggtgtttag gcacagcaga ggggacgcgg     3960

ggggcaagaa cagcaggacg ctggtttaaa aataactcac cgccaaacct gtggagcagt     4020

gtggggcatc ctgccagagg tgcacaggct ggagtttcag gcactgcagg ctgatgacac     4080

acagggagag tggccctgcc tcctgtcctc cccggggttt ttgcagactc gaagtctcac     4140

tgcaccagtg tctttgatgg tggtgagggt gggtgatggt gcccagcacc aacagtttta     4200

gtggcctgtc cttgacctgc cgtggtcctt tgtaaactat ggctccatgc tgtgtgacag     4260

atcaacgtgc tgatggtaag tagactaggc ttccccaggc atgccgtccg tgggggcctg     4320

aagagacagt gagtgccatt ggccccattc gcagatgtgg gagactctgc tcaggcctgt     4380

gaggctgggc agcccttcac cagagttcgg aggagcagtg tgtggcgcca cgtcccgact     4440

ggccataccc acacagaagc agtgctgccc ggggcctcat ctgggccagc ttggactctg     4500

cttcctccag gagcagcagg gaagctctgg gccacctccc tggatagcag gaacttgacc     4560

tgccatgtgt gccctgcctt cctggccagc tgtgcttgtt atcttccatt ctcacaaact     4620

gtctttgaag caatagaata aagaatgtgt gttttctttc ctggtataca tacatgatcc     4680

catgctccca agctccattc ttccttccct caactctctg ccctccacag agctatggag     4740

aaggctggag atgaaagctt tgtagtgagg actgataaag atctcatcac tgctccttat     4800

aataaaccta ataaagcaag aaaccaagcc taaaaaaaaa aaaaaaaaaa a              4851


<210>  13
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Glu Ala Glu Glu Gln Glu Thr Gly Ser Leu Glu Glu Ser Thr 
1               5                   10                  15      


Asp Glu Ser Glu Glu Glu Glu Ser Glu Glu Glu Pro Lys Leu Lys Tyr 
            20                  25                  30          


Glu Arg Leu Ser Asn Gly Val Thr Glu Ile Leu Gln Lys Asp Ala Ala 
        35                  40                  45              


Ser Cys Met Thr Val His Asp Lys Phe Leu Ala Leu Gly Thr His Tyr 
    50                  55                  60                  


Gly Lys Val Tyr Leu Leu Asp Val Gln Gly Asn Ile Thr Gln Lys Phe 
65                  70                  75                  80  


Asp Val Ser Pro Val Lys Ile Asn Gln Ile Ser Leu Asp Glu Ser Gly 
                85                  90                  95      


Glu His Met Gly Val Cys Ser Glu Asp Gly Lys Val Gln Val Phe Gly 
            100                 105                 110         


Leu Tyr Ser Gly Glu Glu Phe His Glu Thr Phe Asp Cys Pro Ile Lys 
        115                 120                 125             


Ile Ile Ala Val His Pro His Phe Val Arg Ser Ser Cys Lys Gln Phe 
    130                 135                 140                 


Val Thr Gly Gly Lys Lys Leu Leu Leu Phe Glu Arg Ser Trp Met Asn 
145                 150                 155                 160 


Arg Trp Lys Ser Ala Val Leu His Glu Gly Glu Gly Asn Ile Arg Ser 
                165                 170                 175     


Val Lys Trp Arg Gly His Leu Ile Ala Trp Ala Asn Asn Met Gly Val 
            180                 185                 190         


Lys Ile Phe Asp Ile Ile Ser Lys Gln Arg Ile Thr Asn Val Pro Arg 
        195                 200                 205             


Asp Asp Ile Ser Leu Arg Pro Asp Met Tyr Pro Cys Ser Leu Cys Trp 
    210                 215                 220                 


Lys Asp Asn Val Thr Leu Ile Ile Gly Trp Gly Thr Ser Val Lys Val 
225                 230                 235                 240 


Cys Ser Val Lys Glu Arg His Ala Ser Glu Met Arg Asp Leu Pro Ser 
                245                 250                 255     


Arg Tyr Val Glu Ile Val Ser Gln Phe Glu Thr Glu Phe Tyr Ile Ser 
            260                 265                 270         


Gly Leu Ala Pro Leu Cys Asp Gln Leu Val Val Leu Ser Tyr Val Lys 
        275                 280                 285             


Glu Ile Ser Glu Lys Thr Glu Arg Glu Tyr Cys Ala Arg Pro Arg Leu 
    290                 295                 300                 


Asp Ile Ile Gln Pro Leu Ser Glu Thr Cys Glu Glu Ile Ser Ser Asp 
305                 310                 315                 320 


Ala Leu Thr Val Arg Gly Phe Gln Glu Asn Glu Cys Arg Asp Tyr His 
                325                 330                 335     


Leu Glu Tyr Ser Glu Gly Glu Ser Leu Phe Tyr Ile Val Ser Pro Arg 
            340                 345                 350         


Asp Val Val Val Ala Lys Glu Arg Asp Gln Asp Asp His Ile Asp Trp 
        355                 360                 365             


Leu Leu Glu Lys Lys Lys Tyr Glu Glu Ala Leu Met Ala Ala Glu Ile 
    370                 375                 380                 


Ser Gln Lys Asn Ile Lys Arg His Lys Ile Leu Asp Ile Gly Leu Ala 
385                 390                 395                 400 


Tyr Ile Asn His Leu Val Glu Arg Gly Asp Tyr Asp Ile Ala Ala Arg 
                405                 410                 415     


Lys Cys Gln Lys Ile Leu Gly Lys Asn Ala Ala Leu Trp Glu Tyr Glu 
            420                 425                 430         


Val Tyr Lys Phe Lys Glu Ile Gly Gln Leu Lys Ala Ile Ser Pro Tyr 
        435                 440                 445             


Leu Pro Arg Gly Asp Pro Val Leu Lys Pro Leu Ile Tyr Glu Met Ile 
    450                 455                 460                 


Leu His Glu Phe Leu Glu Ser Asp Tyr Glu Gly Phe Ala Thr Leu Ile 
465                 470                 475                 480 


Arg Glu Trp Pro Gly Asp Leu Tyr Asn Asn Ser Val Ile Val Gln Ala 
                485                 490                 495     


Val Arg Asp His Leu Lys Lys Asp Ser Gln Asn Lys Thr Leu Leu Lys 
            500                 505                 510         


Thr Leu Ala Glu Leu Tyr Thr Tyr Asp Lys Asn Tyr Gly Asn Ala Leu 
        515                 520                 525             


Glu Ile Tyr Leu Thr Leu Arg His Lys Asp Val Phe Gln Leu Ile His 
    530                 535                 540                 


Lys His Asn Leu Phe Ser Ser Ile Lys Asp Lys Ile Val Leu Leu Met 
545                 550                 555                 560 


Asp Phe Asp Ser Glu Lys Ala Val Asp Met Leu Leu Asp Asn Glu Asp 
                565                 570                 575     


Lys Ile Ser Ile Lys Lys Val Val Glu Glu Leu Glu Asp Arg Pro Glu 
            580                 585                 590         


Leu Gln His Val Tyr Leu His Lys Leu Phe Lys Arg Asp His His Lys 
        595                 600                 605             


Gly Gln Arg Tyr His Glu Lys Gln Ile Ser Leu Tyr Ala Glu Tyr Asp 
    610                 615                 620                 


Arg Pro Asn Leu Leu Pro Phe Leu Arg Asp Ser Thr His Cys Pro Leu 
625                 630                 635                 640 


Glu Lys Ala Leu Glu Ile Cys Gln Gln Arg Asn Phe Val Glu Glu Thr 
                645                 650                 655     


Val Tyr Leu Leu Ser Arg Met Gly Asn Ser Arg Ser Ala Leu Lys Met 
            660                 665                 670         


Ile Met Glu Glu Leu His Asp Val Asp Lys Ala Ile Glu Phe Ala Lys 
        675                 680                 685             


Glu Gln Asp Asp Gly Glu Leu Trp Glu Asp Leu Ile Leu Tyr Ser Ile 
    690                 695                 700                 


Asp Lys Pro Pro Phe Ile Thr Gly Leu Leu Asn Asn Ile Gly Thr His 
705                 710                 715                 720 


Val Asp Pro Ile Leu Leu Ile His Arg Ile Lys Glu Gly Met Glu Ile 
                725                 730                 735     


Pro Asn Leu Arg Asp Ser Leu Val Lys Ile Leu Gln Asp Tyr Asn Leu 
            740                 745                 750         


Gln Ile Leu Leu Arg Glu Gly Cys Lys Lys Ile Leu Val Ala Asp Ser 
        755                 760                 765             


Leu Ser Leu Leu Lys Lys Met His Arg Thr Gln Met Lys Gly Val Leu 
    770                 775                 780                 


Val Asp Glu Glu Asn Ile Cys Glu Ser Cys Leu Ser Pro Ile Leu Pro 
785                 790                 795                 800 


Ser Asp Ala Ala Lys Pro Phe Ser Val Val Val Phe His Cys Arg His 
                805                 810                 815     


Met Phe His Lys Glu Cys Leu Pro Met Pro Ser Met Asn Ser Ala Ala 
            820                 825                 830         


Gln Phe Cys Asn Ile Cys Ser Ala Lys Asn Arg Gly Pro Gly Ser Ala 
        835                 840                 845             


Ile Leu Glu Met Lys Lys 
    850                 


<210>  14
<211>  4894
<212>  DNA
<213>  Homo sapiens

<400>  14
ctgtcaggtg actctcccgt ggcgccatgg cggaagcaga ggagcaggaa actgggtccc       60

ttgaagaatc tacagatgag tctgaggaag aagagagcga agaggaaccc aagctgaagt      120

atgaaaggct ttccaatggg gtaactgaaa tacttcagaa ggatgcagct agctgcatga      180

cagtccatga caagtttttg gcattgggca cacattatgg caaggtttat ttacttgatg      240

tccaggggaa catcactcag aagtttgatg taagtcctgt gaagataaat cagattagct      300

tggatgaaag tggagagcac atgggtgtgt gttcagagga tggcaaggtg caggtatttg      360

gactgtattc tggagaagaa tttcacgaga cttttgactg tcccattaaa attattgctg      420

tgcacccaca tttcgtgaga tccagttgca agcagtttgt gaccggaggg aagaagctgc      480

tactgtttga acggtcttgg atgaacagat ggaagtctgc tgttctgcat gaaggggaag      540

ggaacataag gagtgtgaag tggagaggcc atctgattgc ttgggccaat aatatgggtg      600

tgaagatttt tgacatcatc tcaaagcaaa gaatcaccaa tgtgccccgg gatgatataa      660

gtcttcgccc agacatgtat ccctgcagcc tctgctggaa ggacaatgtg acactgatta      720

ttggctgggg gacttctgtc aaggtgtgct cagtgaagga acggcatgcc agtgaaatga      780

gggatttgcc aagtcgatat gttgaaatag tgtctcagtt tgaaactgaa ttctacatca      840

gtggacttgc acctctctgt gatcagcttg ttgtactttc gtatgtaaag gagatttcag      900

aaaaaacgga aagagaatac tgtgccaggc ctagactgga catcatccag ccactttctg      960

agacttgtga agagatctct tctgatgctt tgacagtcag aggctttcag gagaatgaat     1020

gtagagatta tcatttagaa tactctgaag gggaatcact tttttacatc gtgagtccga     1080

gagatgttgt agtggccaag gaacgagacc aagatgatca cattgactgg ctccttgaaa     1140

agaagaaata tgaagaagca ttgatggcag ctgaaattag ccaaaaaaat attaaaagac     1200

ataagattct ggatattggc ttggcatata taaatcacct ggtggagaga ggagactatg     1260

acatagcagc acgcaaatgc cagaaaattc ttgggaaaaa tgcagcactc tgggaatatg     1320

aagtttataa atttaaagaa attggacagc ttaaggctat tagtccttat ttgccaagag     1380

gtgatccagt tctgaaacca ctcatctatg aaatgatctt acatgaattt ttggagagtg     1440

attatgaggg ttttgccaca ttgatccgag aatggcctgg agatctgtat aataattcag     1500

tcatagttca agcagttcgg gatcatttga agaaagatag tcagaacaag actttactta     1560

aaaccctggc agaattgtac acctatgaca agaactatgg caatgctctg gaaatatact     1620

taacattaag acataaagac gtttttcagt tgatccacaa gcataatctt ttcagttcta     1680

tcaaggataa aattgtttta ttaatggatt ttgattcaga gaaagctgtt gacatgcttt     1740

tggacaatga agataaaatt tcaattaaaa aggtagtgga agaattggaa gacagaccag     1800

agctacagca tgtgtatttg cataagcttt tcaagagaga ccaccataag gggcagcgtt     1860

accatgaaaa acagatcagt ctttatgctg aatatgatcg accaaactta cttccctttc     1920

tccgagacag tacccattgc ccacttgaaa aggctcttga gatctgtcaa cagagaaact     1980

ttgtagaaga gacagtttat cttctgagcc gaatgggtaa tagccgaagt gccctgaaga     2040

tgattatgga ggaattacat gatgttgata aagcaatcga atttgccaag gagcaagatg     2100

atggagagct gtgggaagat ttgattttat attccattga caaaccacca tttattactg     2160

gcttgttaaa caacattggc acacatgttg acccaattct actgattcac cgtattaagg     2220

aaggaatgga gatccccaat ttgagagatt ccttggttaa aattctgcaa gactacaatt     2280

tgcaaattct gcttcgtgaa ggctgcaaga agattctcgt agctgactct ttgtccttac     2340

tgaagaaaat gcaccgaact caaatgaaag gtgttcttgt tgatgaggag aacatctgtg     2400

agtcgtgcct ttcccctatt cttccatcag atgcagctaa gcccttcagc gtggtggtct     2460

tccattgccg gcacatgttc cacaaggagt gcctgcccat gcccagcatg aactctgctg     2520

cacagttctg caacatctgc agtgctaaga accgtggacc aggaagtgca attttggaga     2580

tgaaaaaata gctcatttct ccttgtcagt ctccttgtca ccactctttt tgagactgtt     2640

tttgcaacaa caaaagcatt tgttgacact cgtgctgtta agagatttgt ttatgtttat     2700

attatactca aaaacaattt cttcatctat tcctgtacta atggtttctc tttgcagttc     2760

acagagaatt tggggctctc ttcatgcctt gaaattttgg ggtccatagt gaatattttg     2820

ttatttattt gtttggctca ttctttatat agtaatggaa acataagtct aggagttaga     2880

aatgaatttt ttagacctta gtaaaaccat ttaaccataa aatggacaac tgagaattct     2940

cccagctgcc tgaaagcgtc gccaactgtg gttatcctgc aagctgctac ctgcaacttg     3000

gacgttgttt ccacgtgctc tgctggctac gattcttgca ttctgggttt ggcttttttc     3060

tgtgtcatca actatggtta tcctctaaat aggcatttaa tgaaacattg tacaaattgt     3120

cactcatttg atgacacctg ggaataacat tagcaggctg atgtcctgca ccattatgtt     3180

tactaatcac atgttctgtg tgctgtgacg actgtcaaag agtatctggc catggcggac     3240

actcagcatt tgttgattga ataaatgtta gctcttctca ttgtgaagga ctcactttta     3300

ctgggataaa caaatgcagt taagaattct ggcacccttg taaggaagaa aagagagttc     3360

aacaccttcg agtctgagcg cttgtggcta gagtttgcca ggagggagga aaccagtgac     3420

cctgaaaact gagggtgcct caggagcagt gggaccacct gatgctgaag gacggactaa     3480

tgatgtttcc tcttgccttc tctggtgcct ccattgccct catggaacag agcatatcat     3540

agagggagaa aagtcaaact tgtaattgtg tcttacagtt actggcttca tcttccttgg     3600

gatatatggt catcctctaa tgagtgtaaa agtgcgcaaa acacatcctt attgttcctg     3660

atctcttagt cccataaatg ggaacaaata cagctttctg cttctttctt tttggggaaa     3720

ggacagggtg ctagtgagta ctgacagcat gccagctacc gaagtcaccc agccattccc     3780

atgagcagca gttcatttaa ttgtcacagc gtcgccagga agaagatctg ataaacctag     3840

gtttacagat aaagaaagca aaatgtagag atgttgttga ggtcacagag gtgactgcct     3900

aacttcagag cagggcttct gatcccttta agaaattaca gggccagccg ggcatggtgg     3960

ctcacgcccg taatcccagg gctttgggag gccttggcag gtggatcacc tgagatcgca     4020

cgttcgagac cagcctgacc aacatggaga aaccccatct ctactaaaaa cacaaattag     4080

ccaggcgtgg tggtacatgc ctgtaatccc agctactcag gaggctgagg caggagaatc     4140

acttgacccc aggagacgta ggttgtggtg agctgagatc gcgccattgc actccagcct     4200

gggcaacaag agcaaaactc cgtctcaaaa aagaaaagaa aagaaaagaa atcatagggc     4260

caagttcaaa ggaaatgcac agaacatatc ttcacattag agttaagaat tctctagcaa     4320

acaacagatt tttttgttgt tgttagtcac aaatacttag aactggaagg ctctttgtta     4380

ttattgaatg tacccctcag ccttctcagc atttccttat cccaagacta gtgtgctttc     4440

tgctacactg ctagttttca gttttgttct tacccaattg ttttttcttt tcaacattac     4500

caatttacag attcagttta ttacatttac attaatcctc acttatgatt tgagcaagct     4560

catttccaga aaagtttact ttaagatcat caataggatt tgctaatttc agtgaagtca     4620

ttttgcttca ggggtaaatt atcctagtta ccaagtccta tttggacata aagaaaatcc     4680

tacttataga aaaggagaaa ataattaaac agtcttcatt tttaagtaac tgatttaaaa     4740

ggaaaataat aaaatatgtt cgtttatcat ttcagaaatt gctgtaacac actggaaaat     4800

tcctgaacaa tatagatttt atcgttaata aaaaacacta gctttcgttc cttagaatgt     4860

cttttctttt gaataaacag tattgggtga ttta                                 4894


<210>  15
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Pro Gly Ser Arg Gly Glu Arg Ser Ser Phe Arg Ser Arg Arg 
1               5                   10                  15      


Gly Pro Gly Val Pro Ser Pro Gln Pro Asp Val Thr Met Leu Ser Arg 
            20                  25                  30          


Leu Leu Lys Glu His Gln Ala Lys Gln Asn Glu Arg Lys Glu Leu Gln 
        35                  40                  45              


Glu Lys Arg Arg Arg Glu Ala Ile Thr Ala Ala Thr Cys Leu Thr Glu 
    50                  55                  60                  


Ala Leu Val Asp His Leu Asn Val Gly Val Ala Gln Ala Tyr Met Asn 
65                  70                  75                  80  


Gln Arg Lys Leu Asp His Glu Val Lys Thr Leu Gln Val Gln Ala Ala 
                85                  90                  95      


Gln Phe Ala Lys Gln Thr Gly Gln Trp Ile Gly Met Val Glu Asn Phe 
            100                 105                 110         


Asn Gln Ala Leu Lys Glu Ile Gly Asp Val Glu Asn Trp Ala Arg Ser 
        115                 120                 125             


Ile Glu Leu Asp Met Arg Thr Ile Ala Thr Ala Leu Glu Tyr Val Tyr 
    130                 135                 140                 


Lys Gly Gln Leu Gln Ser Ala Pro Ser 
145                 150             


<210>  16
<211>  590
<212>  DNA
<213>  Homo sapiens

<400>  16
acacagcggt cacgtgacat ggccccgggg agccgaggtg agcgttccag cttccggagc       60

cggagggggc ccggcgtacc cagcccccag cccgacgtga ccatgctgtc ccgcctccta      120

aaagaacacc aggccaagca gaatgaacgc aaggagctgc aggaaaagag gaggcgagag      180

gctatcactg cagcgacctg cctgacagaa gctttggtgg atcacctcaa tgtgggtgtg      240

gcccaggcct acatgaacca gagaaagctg gaccatgagg tgaagaccct acaggtccag      300

gctgcccaat ttgccaagca gacaggccag tggatcggaa tggtggagaa cttcaaccag      360

gcactcaagg aaattgggga tgtggagaac tgggctcgga gcatcgagct ggacatgcgc      420

accattgcca ctgcactgga atatgtctac aaagggcagc tgcagtctgc cccttcctag      480

cccctgttcc ctcccccaac cctatccctc ctacctcacc cgcaggggga aggagggagg      540

ctgacaagcc ttgaataaaa cacaagcctc cgtttctcaa aaaaaaaaaa                 590


<210>  17
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Ala Ala Ala Glu Gly Val Leu Ala Thr Arg Ser Asp Glu Pro 
1               5                   10                  15      


Ala Arg Asp Asp Ala Ala Val Glu Thr Ala Glu Glu Ala Lys Glu Pro 
            20                  25                  30          


Ala Glu Ala Asp Ile Thr Glu Leu Cys Arg Asp Met Phe Ser Lys Met 
        35                  40                  45              


Ala Thr Tyr Leu Thr Gly Glu Leu Thr Ala Thr Ser Glu Asp Tyr Lys 
    50                  55                  60                  


Leu Leu Glu Asn Met Asn Lys Leu Thr Ser Leu Lys Tyr Leu Glu Met 
65                  70                  75                  80  


Lys Asp Ile Ala Ile Asn Ile Ser Arg Asn Leu Lys Asp Leu Asn Gln 
                85                  90                  95      


Lys Tyr Ala Gly Leu Gln Pro Tyr Leu Asp Gln Ile Asn Val Ile Glu 
            100                 105                 110         


Glu Gln Val Ala Ala Leu Glu Gln Ala Ala Tyr Lys Leu Asp Ala Tyr 
        115                 120                 125             


Ser Lys Lys Leu Glu Ala Lys Tyr Lys Lys Leu Glu Lys Arg 
    130                 135                 140         


<210>  18
<211>  1958
<212>  DNA
<213>  Homo sapiens

<400>  18
ccggaaacag cgcggggtcc gctatggcgg cggcagccga gggcgtactg gcgacccgga       60

gtgatgagcc cgcccgagac gatgccgccg tggagacagc tgaggaagca aaggagcctg      120

ctgaagctga catcactgag ctctgccggg acatgttctc caaaatggcc acttacctga      180

ctggggaact gacggccacc agtgaagact ataagctcct ggaaaatatg aataaactca      240

ccagcttgaa gtatcttgaa atgaaagata ttgctataaa cattagtagg aacttaaagg      300

acttaaacca gaaatatgct ggactgcagc cttatctgga tcagatcaat gtcattgaag      360

agcaggtagc agctcttgag caggcagctt acaagttgga tgcatattca aaaaaactgg      420

aagccaagta caagaagctg gagaagcgat gagaaactta tttctatggg acagagtctt      480

ttttttttaa tgtggaagaa tgtcttataa aacctgaatc ctgaggctga tgaattgtga      540

aaattcctca aaaggaaatt atgctggtca tcacaggaac atctcaacgt tcgagtaaac      600

tggaggactg tggctattcc tgaaccttct ttgagacaga atccctcaga atctcacact      660

tataacttcc taccttttac ttgaatgctt tgccatattc aggacagaga ctctcacaaa      720

gttcagaaaa cagctggact taccagtaaa atcaaatgag aggacctatt ttctctggta      780

gtggttgatt actacattat tttcttaagt ggctggtttt ttagttacta tgtaaatggt      840

cgtttttctg ttaatgatgc taatgtgttg taaacaagat tctaaattta aaaaggaaaa      900

caaaacaaac ttgttctttg cagcttatca ccttgtgaat gtcggtaact tacttttcca      960

taatattgca aataacataa aatcttaaaa taattccaag ctgagtcttc tagattgagc     1020

agaaatggtg aaaggagtat tgataacttg gcgtatgtga tgggcccctc ttgtttattt     1080

tctatgtgag tcacattgac atgcgatcag tttgggaaat gtgatgaaaa caaagactag     1140

atgggtatgt gtgtttatgt gttgggtagg gaggtgacga ttgccactca taaaataaag     1200

gattttataa aataccttcc tactgtgtat gtaggatttg gggggatctt agggacctaa     1260

tcgacttctt tgcacactaa aaacatcaga caatgggaca tactgactga ccagtctagg     1320

ttgaaagata ggcagcctta cccagaacac aacattagca gctgggaagg tgtctgaggt     1380

ccccaattac atatcccaaa gagtttctta cttctgtttc tgtcatttcc cctctgttcc     1440

agacagtcat catttatcct ctgttcttcc tggactgttg ctgtggtctc ttctcatctt     1500

aactgtccct tccaaccacc ctccacactg ctgccagagc aatcttaaaa atgtaaactg     1560

gccctattac tcctgcttag aaccctgtag tgacttatca tggcctctga aaaatctaga     1620

ctttcattat gcatacaagt cccttgtgtt tttttgtttg tttatagaca gggtctctat     1680

tgtcacccag gctggagtgt ggtggtgtga taatagctca ccttgacctc ctaggctcaa     1740

ctgatcttcc cacctcagcc tcctgaatag ctgggactac cagcacgctc caccatgcct     1800

tgctaattat tttttataca gatggagtct cactatgttg tccaggctgg tcttgaactg     1860

gcctcaagtg attctcttac cacagcctgc cagagtgctg agattgtagg catgaaccac     1920

cgtgcctaac ataaggcccc tatttaaaca tttttctt                             1958


<210>  19
<211>  1256
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Leu Phe Lys Leu Leu Gln Arg Gln Thr Tyr Thr Cys Leu Ser His 
1               5                   10                  15      


Arg Tyr Gly Leu Tyr Val Cys Phe Leu Gly Val Val Val Thr Ile Val 
            20                  25                  30          


Ser Ala Phe Gln Phe Gly Glu Val Val Leu Glu Trp Ser Arg Asp Gln 
        35                  40                  45              


Tyr His Val Leu Phe Asp Ser Tyr Arg Asp Asn Ile Ala Gly Lys Ser 
    50                  55                  60                  


Phe Gln Asn Arg Leu Cys Leu Pro Met Pro Ile Asp Val Val Tyr Thr 
65                  70                  75                  80  


Trp Val Asn Gly Thr Asp Leu Glu Leu Leu Lys Glu Leu Gln Gln Val 
                85                  90                  95      


Arg Glu Gln Met Glu Glu Glu Gln Lys Ala Met Arg Glu Ile Leu Gly 
            100                 105                 110         


Lys Asn Thr Thr Glu Pro Thr Lys Lys Ser Glu Lys Gln Leu Glu Cys 
        115                 120                 125             


Leu Leu Thr His Cys Ile Lys Val Pro Met Leu Val Leu Asp Pro Ala 
    130                 135                 140                 


Leu Pro Ala Asn Ile Thr Leu Lys Asp Leu Pro Ser Leu Tyr Pro Ser 
145                 150                 155                 160 


Phe His Ser Ala Ser Asp Ile Phe Asn Val Ala Lys Pro Lys Asn Pro 
                165                 170                 175     


Ser Thr Asn Val Ser Val Val Val Phe Asp Ser Thr Lys Asp Val Glu 
            180                 185                 190         


Asp Ala His Ser Gly Leu Leu Lys Gly Asn Ser Arg Gln Thr Val Trp 
        195                 200                 205             


Arg Gly Tyr Leu Thr Thr Asp Lys Glu Val Pro Gly Leu Val Leu Met 
    210                 215                 220                 


Gln Asp Leu Ala Phe Leu Ser Gly Phe Pro Pro Thr Phe Lys Glu Thr 
225                 230                 235                 240 


Asn Gln Leu Lys Thr Lys Leu Pro Glu Asn Leu Ser Ser Lys Val Lys 
                245                 250                 255     


Leu Leu Gln Leu Tyr Ser Glu Ala Ser Val Ala Leu Leu Lys Leu Asn 
            260                 265                 270         


Asn Pro Lys Asp Phe Gln Glu Leu Asn Lys Gln Thr Lys Lys Asn Met 
        275                 280                 285             


Thr Ile Asp Gly Lys Glu Leu Thr Ile Ser Pro Ala Tyr Leu Leu Trp 
    290                 295                 300                 


Asp Leu Ser Ala Ile Ser Gln Ser Lys Gln Asp Glu Asp Ile Ser Ala 
305                 310                 315                 320 


Ser Arg Phe Glu Asp Asn Glu Glu Leu Arg Tyr Ser Leu Arg Ser Ile 
                325                 330                 335     


Glu Arg His Ala Pro Trp Val Arg Asn Ile Phe Ile Val Thr Asn Gly 
            340                 345                 350         


Gln Ile Pro Ser Trp Leu Asn Leu Asp Asn Pro Arg Val Thr Ile Val 
        355                 360                 365             


Thr His Gln Asp Val Phe Arg Asn Leu Ser His Leu Pro Thr Phe Ser 
    370                 375                 380                 


Ser Pro Ala Ile Glu Ser His Ile His Arg Ile Glu Gly Leu Ser Gln 
385                 390                 395                 400 


Lys Phe Ile Tyr Leu Asn Asp Asp Val Met Phe Gly Lys Asp Val Trp 
                405                 410                 415     


Pro Asp Asp Phe Tyr Ser His Ser Lys Gly Gln Lys Val Tyr Leu Thr 
            420                 425                 430         


Trp Pro Val Pro Asn Cys Ala Glu Gly Cys Pro Gly Ser Trp Ile Lys 
        435                 440                 445             


Asp Gly Tyr Cys Asp Lys Ala Cys Asn Asn Ser Ala Cys Asp Trp Asp 
    450                 455                 460                 


Gly Gly Asp Cys Ser Gly Asn Ser Gly Gly Ser Arg Tyr Ile Ala Gly 
465                 470                 475                 480 


Gly Gly Gly Thr Gly Ser Ile Gly Val Gly Gln Pro Trp Gln Phe Gly 
                485                 490                 495     


Gly Gly Ile Asn Ser Val Ser Tyr Cys Asn Gln Gly Cys Ala Asn Ser 
            500                 505                 510         


Trp Leu Ala Asp Lys Phe Cys Asp Gln Ala Cys Asn Val Leu Ser Cys 
        515                 520                 525             


Gly Phe Asp Ala Gly Asp Cys Gly Gln Asp His Phe His Glu Leu Tyr 
    530                 535                 540                 


Lys Val Ile Leu Leu Pro Asn Gln Thr His Tyr Ile Ile Pro Lys Gly 
545                 550                 555                 560 


Glu Cys Leu Pro Tyr Phe Ser Phe Ala Glu Val Ala Lys Arg Gly Val 
                565                 570                 575     


Glu Gly Ala Tyr Ser Asp Asn Pro Ile Ile Arg His Ala Ser Ile Ala 
            580                 585                 590         


Asn Lys Trp Lys Thr Ile His Leu Ile Met His Ser Gly Met Asn Ala 
        595                 600                 605             


Thr Thr Ile His Phe Asn Leu Thr Phe Gln Asn Thr Asn Asp Glu Glu 
    610                 615                 620                 


Phe Lys Met Gln Ile Thr Val Glu Val Asp Thr Arg Glu Gly Pro Lys 
625                 630                 635                 640 


Leu Asn Ser Thr Ala Gln Lys Gly Tyr Glu Asn Leu Val Ser Pro Ile 
                645                 650                 655     


Thr Leu Leu Pro Glu Ala Glu Ile Leu Phe Glu Asp Ile Pro Lys Glu 
            660                 665                 670         


Lys Arg Phe Pro Lys Phe Lys Arg His Asp Val Asn Ser Thr Arg Arg 
        675                 680                 685             


Ala Gln Glu Glu Val Lys Ile Pro Leu Val Asn Ile Ser Leu Leu Pro 
    690                 695                 700                 


Lys Asp Ala Gln Leu Ser Leu Asn Thr Leu Asp Leu Gln Leu Glu His 
705                 710                 715                 720 


Gly Asp Ile Thr Leu Lys Gly Tyr Asn Leu Ser Lys Ser Ala Leu Leu 
                725                 730                 735     


Arg Ser Phe Leu Met Asn Ser Gln His Ala Lys Ile Lys Asn Gln Ala 
            740                 745                 750         


Ile Ile Thr Asp Glu Thr Asn Asp Ser Leu Val Ala Pro Gln Glu Lys 
        755                 760                 765             


Gln Val His Lys Ser Ile Leu Pro Asn Ser Leu Gly Val Ser Glu Arg 
    770                 775                 780                 


Leu Gln Arg Leu Thr Phe Pro Ala Val Ser Val Lys Val Asn Gly His 
785                 790                 795                 800 


Asp Gln Gly Gln Asn Pro Pro Leu Asp Leu Glu Thr Thr Ala Arg Phe 
                805                 810                 815     


Arg Val Glu Thr His Thr Gln Lys Thr Ile Gly Gly Asn Val Thr Lys 
            820                 825                 830         


Glu Lys Pro Pro Ser Leu Ile Val Pro Leu Glu Ser Gln Met Thr Lys 
        835                 840                 845             


Glu Lys Lys Ile Thr Gly Lys Glu Lys Glu Asn Ser Arg Met Glu Glu 
    850                 855                 860                 


Asn Ala Glu Asn His Ile Gly Val Thr Glu Val Leu Leu Gly Arg Lys 
865                 870                 875                 880 


Leu Gln His Tyr Thr Asp Ser Tyr Leu Gly Phe Leu Pro Trp Glu Lys 
                885                 890                 895     


Lys Lys Tyr Phe Gln Asp Leu Leu Asp Glu Glu Glu Ser Leu Lys Thr 
            900                 905                 910         


Gln Leu Ala Tyr Phe Thr Asp Ser Lys Asn Thr Gly Arg Gln Leu Lys 
        915                 920                 925             


Asp Thr Phe Ala Asp Ser Leu Arg Tyr Val Asn Lys Ile Leu Asn Ser 
    930                 935                 940                 


Lys Phe Gly Phe Thr Ser Arg Lys Val Pro Ala His Met Pro His Met 
945                 950                 955                 960 


Ile Asp Arg Ile Val Met Gln Glu Leu Gln Asp Met Phe Pro Glu Glu 
                965                 970                 975     


Phe Asp Lys Thr Ser Phe His Lys Val Arg His Ser Glu Asp Met Gln 
            980                 985                 990         


Phe Ala Phe Ser Tyr Phe Tyr Tyr  Leu Met Ser Ala Val  Gln Pro Leu 
        995                 1000                 1005             


Asn Ile  Ser Gln Val Phe Asp  Glu Val Asp Thr Asp  Gln Ser Gly 
    1010                 1015                 1020             


Val Leu  Ser Asp Arg Glu Ile  Arg Thr Leu Ala Thr  Arg Ile His 
    1025                 1030                 1035             


Glu Leu  Pro Leu Ser Leu Gln  Asp Leu Thr Gly Leu  Glu His Met 
    1040                 1045                 1050             


Leu Ile  Asn Cys Ser Lys Met  Leu Pro Ala Asp Ile  Thr Gln Leu 
    1055                 1060                 1065             


Asn Asn  Ile Pro Pro Thr Gln  Glu Ser Tyr Tyr Asp  Pro Asn Leu 
    1070                 1075                 1080             


Pro Pro  Val Thr Lys Ser Leu  Val Thr Asn Cys Lys  Pro Val Thr 
    1085                 1090                 1095             


Asp Lys  Ile His Lys Ala Tyr  Lys Asp Lys Asn Lys  Tyr Arg Phe 
    1100                 1105                 1110             


Glu Ile  Met Gly Glu Glu Glu  Ile Ala Phe Lys Met  Ile Arg Thr 
    1115                 1120                 1125             


Asn Val  Ser His Val Val Gly  Gln Leu Asp Asp Ile  Arg Lys Asn 
    1130                 1135                 1140             


Pro Arg  Lys Phe Val Cys Leu  Asn Asp Asn Ile Asp  His Asn His 
    1145                 1150                 1155             


Lys Asp  Ala Gln Thr Val Lys  Ala Val Leu Arg Asp  Phe Tyr Glu 
    1160                 1165                 1170             


Ser Met  Phe Pro Ile Pro Ser  Gln Phe Glu Leu Pro  Arg Glu Tyr 
    1175                 1180                 1185             


Arg Asn  Arg Phe Leu His Met  His Glu Leu Gln Glu  Trp Arg Ala 
    1190                 1195                 1200             


Tyr Arg  Asp Lys Leu Lys Phe  Trp Thr His Cys Val  Leu Ala Thr 
    1205                 1210                 1215             


Leu Ile  Met Phe Thr Ile Phe  Ser Phe Phe Ala Glu  Gln Leu Ile 
    1220                 1225                 1230             


Ala Leu  Lys Arg Lys Ile Phe  Pro Arg Arg Arg Ile  His Lys Glu 
    1235                 1240                 1245             


Ala Ser  Pro Asn Arg Ile Arg  Val 
    1250                 1255     


<210>  20
<211>  5644
<212>  DNA
<213>  Homo sapiens

<400>  20
gctcccggaa gcggcggccg cggcgcggag ccgagcgggc gtccgtcgcc ggagctgcaa       60

tgagcggcgc ccggaggctg tgacctgcgc gcggcggccc gaccggggcc cctgaatggc      120

ggctcgctga ggcggcggcg gcggcggcgg cggctcaggc tcctcggggc gtggcgtggc      180

ggtgaagggg tgatgctgtt caagctcctg cagagacaga cctatacctg cctgtcccac      240

aggtatgggc tctacgtgtg cttcttgggc gtcgttgtca ccatcgtctc cgccttccag      300

ttcggagagg tggttctgga atggagccga gatcaatacc atgttttgtt tgattcctat      360

agagacaata ttgctggaaa gtcctttcag aatcggcttt gtctgcccat gccgattgac      420

gttgtttaca cctgggtgaa tggcacagat cttgaactac tgaaggaact acagcaggtc      480

agagaacaga tggaggagga gcagaaagca atgagagaaa tccttgggaa aaacacaacg      540

gaacctacta agaagagtga gaagcagtta gagtgtttgc taacacactg cattaaggtg      600

ccaatgcttg tcctggaccc agccctgcca gccaacatca ccctgaagga cctgccatct      660

ctttatcctt cttttcattc tgccagtgac attttcaatg ttgcaaaacc aaaaaaccct      720

tctaccaatg tctcagttgt tgtttttgac agtactaagg atgttgaaga tgcccactct      780

ggactgctta aaggaaatag cagacagaca gtatggaggg gctacttgac aacagataaa      840

gaagtccctg gattagtgct aatgcaagat ttggctttcc tgagtggatt tccaccaaca      900

ttcaaggaaa caaatcaact aaaaacaaaa ttgccagaaa atctttcctc taaagtcaaa      960

ctgttgcagt tgtattcaga ggccagtgta gcgcttctaa aactgaataa ccccaaggat     1020

tttcaagaat tgaataagca aactaagaag aacatgacca ttgatggaaa agaactgacc     1080

ataagtcctg catatttatt atgggatctg agcgccatca gccagtctaa gcaggatgaa     1140

gacatctctg ccagtcgttt tgaagataac gaagaactga ggtactcatt gcgatctatc     1200

gagaggcatg caccatgggt tcggaatatt ttcattgtca ccaacgggca gattccatcc     1260

tggctgaacc ttgacaatcc tcgagtgaca atagtaacac accaggatgt ttttcgaaat     1320

ttgagccact tgcctacctt tagttcacct gctattgaaa gtcacattca tcgcatcgaa     1380

gggctgtccc agaagtttat ttacctaaat gatgatgtca tgtttgggaa ggatgtctgg     1440

ccagatgatt tttacagtca ctccaaaggc cagaaggttt atttgacatg gcctgtgcca     1500

aactgtgccg agggctgccc aggttcctgg attaaggatg gctattgtga caaggcttgt     1560

aataattcag cctgcgattg ggatggtggg gattgctctg gaaacagtgg agggagtcgc     1620

tatattgcag gaggtggagg tactgggagt attggagttg gacagccctg gcagtttggt     1680

ggaggaataa acagtgtctc ttactgtaat cagggatgtg cgaattcctg gctcgctgat     1740

aagttctgtg accaagcatg caatgtcttg tcctgtgggt ttgatgctgg cgactgtggg     1800

caagatcatt ttcatgaatt gtataaagtg atccttctcc caaaccagac tcactatatt     1860

attccaaaag gtgaatgcct gccttatttc agctttgcag aagtagccaa aagaggagtt     1920

gaaggtgcct atagtgacaa tccaataatt cgacatgctt ctattgccaa caagtggaaa     1980

accatccacc tcataatgca cagtggaatg aatgccacca caatacattt taatctcacg     2040

tttcaaaata caaacgatga agagttcaaa atgcagataa cagtggaggt ggacacaagg     2100

gagggaccaa aactgaattc tacagcccag aagggttacg aaaatttagt tagtcccata     2160

acacttcttc cagaggcgga aatccttttt gaggatattc ccaaagaaaa acgcttcccg     2220

aagtttaaga gacatgatgt taactcaaca aggagagccc aggaagaggt gaaaattccc     2280

ctggtaaata tttcactcct tccaaaagac gcccagttga gtctcaatac cttggatttg     2340

caactggaac atggagacat cactttgaaa ggatacaatt tgtccaagtc agccttgctg     2400

agatcatttc tgatgaactc acagcatgct aaaataaaaa atcaagctat aataacagat     2460

gaaacaaatg acagtttggt ggctccacag gaaaaacagg ttcataaaag catcttgcca     2520

aacagcttag gagtgtctga aagattgcag aggttgactt ttcctgcagt gagtgtaaaa     2580

gtgaatggtc atgaccaggg tcagaatcca cccctggact tggagaccac agcaagattt     2640

agagtggaaa ctcacaccca aaaaaccata ggcggaaatg tgacaaaaga aaagccccca     2700

tctctgattg ttccactgga aagccagatg acaaaagaaa agaaaatcac agggaaagaa     2760

aaagagaaca gtagaatgga ggaaaatgct gaaaatcaca taggcgttac tgaagtgtta     2820

cttggaagaa agctgcagca ttacacagat agttacttgg gctttttgcc atgggagaaa     2880

aaaaagtatt tccaagatct tctcgacgaa gaagagtcat tgaagacaca attggcatac     2940

ttcactgata gcaaaaatac tgggaggcaa ctaaaagata catttgcaga ttccctcaga     3000

tatgtaaata aaattctaaa tagcaagttt ggattcacat cgcggaaagt ccctgctcac     3060

atgcctcaca tgattgaccg gattgttatg caagaactgc aagatatgtt ccctgaagaa     3120

tttgacaaga cgtcatttca caaagtgcgc cattctgagg atatgcagtt tgccttctct     3180

tatttttatt atctcatgag tgcagtgcag ccactgaata tatctcaagt ctttgatgaa     3240

gttgatacag atcaatctgg tgtcttgtct gacagagaaa tccgaacact ggctaccaga     3300

attcacgaac tgccgttaag tttgcaggat ttgacaggtc tggaacacat gctaataaat     3360

tgctcaaaaa tgcttcctgc tgatatcacg cagctaaata atattccacc aactcaggaa     3420

tcctactatg atcccaacct gccaccggtc actaaaagtc tagtaacaaa ctgtaaacca     3480

gtaactgaca aaatccacaa agcatataag gacaaaaaca aatataggtt tgaaatcatg     3540

ggagaagaag aaatcgcttt taaaatgatt cgtaccaacg tttctcatgt ggttggccag     3600

ttggatgaca taagaaaaaa ccctaggaag tttgtttgcc tgaatgacaa cattgaccac     3660

aatcataaag atgctcagac agtgaaggct gttctcaggg acttctatga atccatgttc     3720

cccatacctt cccaatttga actgccaaga gagtatcgaa accgtttcct tcatatgcat     3780

gagctgcagg aatggagggc ttatcgagac aaattgaagt tttggaccca ttgtgtacta     3840

gcaacattga ttatgtttac tatattctca ttttttgctg agcagttaat tgcacttaag     3900

cggaagatat ttcccagaag gaggatacac aaagaagcta gtcccaatcg aatcagagta     3960

tagaagatct tcatttgaaa accatctacc tcagcattta ctgagcattt taaaactcag     4020

cttcacagag atgtctttgt gatgtgatgc ttagcagttt ggcccgaaga aggaaaatat     4080

ccagtaccat gctgttttgt ggcatgaata tagcccactg accaggaatt atttaaccaa     4140

cccactgaaa acttgtgtgt tgagcagctc tgaactgatt ttacttttaa agaatttgct     4200

catggacctg tcatcctttt tataaaaagg ctcactgaca agagacagct gttaatttcc     4260

cacagcaatc attgcagact aactttatta ggagaagcct atgccagctg ggagtgattg     4320

ctaagaggct ccagtctttg cattccaaag ccttttgcta aagttttgca cttttttttt     4380

ttcatttccc atttttaagt agttactaag ttaactagtt attcttgctt ctgagtataa     4440

cgaattggga tgtctaaacc tatttttata gatgttattt aaataatgca gcaatatcac     4500

ctcttattga caatacctaa attatgagtt ttattaatat ttaagactgt aaatggtctt     4560

aaaccactaa ctactgaaga gctcaatgat tgacatctga aatgctttgt aattattgac     4620

ttcagcccct aagaatgcta tgatttcacg tgcaggtcta atttcaaagg gctagagtta     4680

gtactactta ccagatgtaa ttatgttttg gaaatgtaca tattcaaaca gaagtgcctc     4740

attttagaaa tgagtagtgc tgatggcact ggcacattac agtggtgtct tgtttaatac     4800

tcattggtat attccagtag ctatctctct cagttggttt ttgatagaac agaggccagc     4860

aaactttctt tgtaaaaggc tggttagtaa attattgcag gccacctgtg tctttgtcat     4920

acattcttct tgctgttgtt tagtttgttt tttttcaaac aaccctctaa aaatgtaaaa     4980

accatgttta gcttgcagct gtacaaaaac tgcccaccag ccagatgtga ccctcaggcc     5040

atcatttgcc aatcactgag aattagtttt tgttgttgtt gttgttgttg tttttgagac     5100

agagtctctc tctgttgccc aggctggagt gcagtggcgc aatctcagct cactgcaacc     5160

tccgcctccc gggttcaagc agttctgtct cagccttctg agtagctggg actacaggtg     5220

catgccacca caccctgcta atttttgtat ttttagtaga gacgggggtt ccaccatatt     5280

ggtcaggctt atcttgaact cctgacctca ggtgatccac ctgcctctgc ctcccaaagt     5340

gctgagatta caggcataag ccagtgcacc cagccgagaa ttagtatttt tatgtatggt     5400

taaaccttgg cgtctagcca tattttatgt cataatacaa tggatttgtg aagagcagat     5460

tccatgagta actctgacag gtattttaga tcatgatctc aacaatattc ttccaaaatg     5520

gcatacatct tttgtacaaa gaacttgaaa tgtaaatact gtgtttgtgc tgtaagagtt     5580

gtgtatttca aaaactgaaa tctcataaaa agttaaattt ttgtctgaca aaaaaaaaaa     5640

aaaa                                                                  5644


<210>  21
<211>  2098
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Thr Asp Asp Lys Thr Ser Pro Thr Leu Asp Ser Ala Asn Asp 
1               5                   10                  15      


Leu Pro Arg Ser Pro Thr Ser Pro Ser His Leu Thr His Phe Lys Pro 
            20                  25                  30          


Leu Thr Pro Asp Gln Asp Glu Pro Pro Phe Lys Ser Ala Tyr Ser Ser 
        35                  40                  45              


Phe Val Asn Leu Phe Arg Phe Asn Lys Glu Arg Ala Glu Gly Gly Gln 
    50                  55                  60                  


Gly Glu Gln Gln Pro Leu Ser Gly Ser Trp Thr Ser Pro Gln Leu Pro 
65                  70                  75                  80  


Ser Arg Thr Gln Ser Val Arg Ser Pro Thr Pro Tyr Lys Lys Gln Leu 
                85                  90                  95      


Asn Glu Glu Leu Gln Arg Arg Ser Ser Ala Leu Asp Thr Arg Arg Lys 
            100                 105                 110         


Ala Glu Pro Thr Phe Gly Gly His Asp Pro Arg Thr Ala Val Gln Leu 
        115                 120                 125             


Arg Ser Leu Ser Thr Val Leu Lys Arg Leu Lys Glu Ile Met Glu Gly 
    130                 135                 140                 


Lys Ser Gln Asp Ser Asp Leu Lys Gln Tyr Trp Met Pro Asp Ser Gln 
145                 150                 155                 160 


Cys Lys Glu Cys Tyr Asp Cys Ser Glu Lys Phe Thr Thr Phe Arg Arg 
                165                 170                 175     


Arg His His Cys Arg Leu Cys Gly Gln Ile Phe Cys Ser Arg Cys Cys 
            180                 185                 190         


Asn Gln Glu Ile Pro Gly Lys Phe Met Gly Tyr Thr Gly Asp Leu Arg 
        195                 200                 205             


Ala Cys Thr Tyr Cys Arg Lys Ile Ala Leu Ser Tyr Ala His Ser Thr 
    210                 215                 220                 


Asp Ser Asn Ser Ile Gly Glu Asp Leu Asn Ala Leu Ser Asp Ser Ala 
225                 230                 235                 240 


Cys Ser Val Ser Val Leu Asp Pro Ser Glu Pro Arg Thr Pro Val Gly 
                245                 250                 255     


Ser Arg Lys Ala Ser Arg Asn Ile Phe Leu Glu Asp Asp Leu Ala Trp 
            260                 265                 270         


Gln Ser Leu Ile His Pro Asp Ser Ser Asn Thr Pro Leu Ser Thr Arg 
        275                 280                 285             


Leu Val Ser Val Gln Glu Asp Ala Gly Lys Ser Pro Ala Arg Asn Arg 
    290                 295                 300                 


Ser Ala Ser Ile Thr Asn Leu Ser Leu Asp Arg Ser Gly Ser Pro Met 
305                 310                 315                 320 


Val Pro Ser Tyr Glu Thr Ser Val Ser Pro Gln Ala Asn Arg Thr Tyr 
                325                 330                 335     


Val Arg Thr Glu Thr Thr Glu Asp Glu Arg Lys Ile Leu Leu Asp Ser 
            340                 345                 350         


Val Gln Leu Lys Asp Leu Trp Lys Lys Ile Cys His His Ser Ser Gly 
        355                 360                 365             


Met Glu Phe Gln Asp His Arg Tyr Trp Leu Arg Thr His Pro Asn Cys 
    370                 375                 380                 


Ile Val Gly Lys Glu Leu Val Asn Trp Leu Ile Arg Asn Gly His Ile 
385                 390                 395                 400 


Ala Thr Arg Ala Gln Ala Ile Ala Ile Gly Gln Ala Met Val Asp Gly 
                405                 410                 415     


Arg Trp Leu Asp Cys Val Ser His His Asp Gln Leu Phe Arg Asp Glu 
            420                 425                 430         


Tyr Ala Leu Tyr Arg Pro Leu Gln Ser Thr Glu Phe Ser Glu Thr Pro 
        435                 440                 445             


Ser Pro Asp Ser Asp Ser Val Asn Ser Val Glu Gly His Ser Glu Pro 
    450                 455                 460                 


Ser Trp Phe Lys Asp Ile Lys Phe Asp Asp Ser Asp Thr Glu Gln Ile 
465                 470                 475                 480 


Ala Glu Glu Gly Asp Asp Asn Leu Ala Asn Ser Ala Ser Pro Ser Lys 
                485                 490                 495     


Arg Thr Ser Val Ser Ser Phe Gln Ser Thr Val Asp Ser Asp Ser Ala 
            500                 505                 510         


Ala Ser Ile Ser Leu Asn Val Glu Leu Asp Asn Val Asn Phe His Ile 
        515                 520                 525             


Lys Lys Pro Ser Lys Tyr Pro His Val Pro Pro His Pro Ala Asp Gln 
    530                 535                 540                 


Lys Glu Tyr Leu Ile Ser Asp Thr Gly Gly Gln Gln Leu Ser Ile Ser 
545                 550                 555                 560 


Asp Ala Phe Ile Lys Glu Ser Leu Phe Asn Arg Arg Val Glu Glu Lys 
                565                 570                 575     


Ser Lys Glu Leu Pro Phe Thr Pro Leu Gly Trp His His Asn Asn Leu 
            580                 585                 590         


Glu Leu Leu Arg Glu Glu Asn Gly Glu Lys Gln Ala Met Glu Arg Leu 
        595                 600                 605             


Leu Ser Ala Asn His Asn His Met Met Ala Leu Leu Gln Gln Leu Leu 
    610                 615                 620                 


His Ser Asp Ser Leu Ser Ser Ser Trp Arg Asp Ile Ile Val Ser Leu 
625                 630                 635                 640 


Val Cys Gln Val Val Gln Thr Val Arg Pro Asp Val Lys Asn Gln Asp 
                645                 650                 655     


Asp Asp Met Asp Ile Arg Gln Phe Val His Ile Lys Lys Ile Pro Gly 
            660                 665                 670         


Gly Lys Lys Phe Asp Ser Val Val Val Asn Gly Phe Val Cys Thr Lys 
        675                 680                 685             


Asn Ile Ala His Lys Lys Met Ser Ser Cys Ile Lys Asn Pro Lys Ile 
    690                 695                 700                 


Leu Leu Leu Lys Cys Ser Ile Glu Tyr Leu Tyr Arg Glu Glu Thr Lys 
705                 710                 715                 720 


Phe Thr Cys Ile Asp Pro Ile Val Leu Gln Glu Arg Glu Phe Leu Lys 
                725                 730                 735     


Asn Tyr Val Gln Arg Ile Val Asp Val Arg Pro Thr Leu Val Leu Val 
            740                 745                 750         


Glu Lys Thr Val Ser Arg Ile Ala Gln Asp Met Leu Leu Glu His Gly 
        755                 760                 765             


Ile Thr Leu Val Ile Asn Val Lys Ser Gln Val Leu Glu Arg Ile Ser 
    770                 775                 780                 


Arg Met Thr Gln Gly Asp Leu Val Met Ser Met Asp Gln Leu Leu Thr 
785                 790                 795                 800 


Lys Pro His Leu Gly Thr Cys His Lys Phe Tyr Met Gln Ile Phe Gln 
                805                 810                 815     


Leu Pro Asn Glu Gln Thr Lys Thr Leu Met Phe Phe Glu Gly Cys Pro 
            820                 825                 830         


Gln His Leu Gly Cys Thr Ile Lys Leu Arg Gly Gly Ser Asp Tyr Glu 
        835                 840                 845             


Leu Ala Arg Val Lys Glu Ile Leu Ile Phe Met Ile Cys Val Ala Tyr 
    850                 855                 860                 


His Ser Gln Leu Glu Ile Ser Phe Leu Met Asp Glu Phe Ala Met Pro 
865                 870                 875                 880 


Pro Thr Leu Met Gln Asn Pro Ser Phe His Ser Leu Ile Glu Gly Arg 
                885                 890                 895     


Gly His Glu Gly Ala Val Gln Glu Gln Tyr Gly Gly Gly Ser Ile Pro 
            900                 905                 910         


Trp Asp Pro Asp Ile Pro Pro Glu Ser Leu Pro Cys Asp Asp Ser Ser 
        915                 920                 925             


Leu Leu Glu Leu Arg Ile Val Phe Glu Lys Gly Glu Gln Glu Asn Lys 
    930                 935                 940                 


Asn Leu Pro Gln Ala Val Ala Ser Val Lys His Gln Glu His Ser Thr 
945                 950                 955                 960 


Thr Ala Cys Pro Ala Gly Leu Pro Cys Ala Phe Phe Ala Pro Val Pro 
                965                 970                 975     


Glu Ser Leu Leu Pro Leu Pro Val Asp Asp Gln Gln Asp Ala Leu Gly 
            980                 985                 990         


Ser Glu Gln Pro Glu Thr Leu Gln  Gln Thr Val Val Leu  Gln Asp Pro 
        995                 1000                 1005             


Lys Ser  Gln Ile Arg Ala Phe  Arg Asp Pro Leu Gln  Asp Asp Thr 
    1010                 1015                 1020             


Gly Leu  Tyr Val Thr Glu Glu  Val Thr Ser Ser Glu  Asp Lys Arg 
    1025                 1030                 1035             


Lys Thr  Tyr Ser Leu Ala Phe  Lys Gln Glu Leu Lys  Asp Val Ile 
    1040                 1045                 1050             


Leu Cys  Ile Ser Pro Val Ile  Thr Phe Arg Glu Pro  Phe Leu Leu 
    1055                 1060                 1065             


Thr Glu  Lys Gly Met Arg Cys  Ser Thr Arg Asp Tyr  Phe Ala Glu 
    1070                 1075                 1080             


Gln Val  Tyr Trp Ser Pro Leu  Leu Asn Lys Glu Phe  Lys Glu Met 
    1085                 1090                 1095             


Glu Asn  Arg Arg Lys Lys Gln  Leu Leu Arg Asp Leu  Ser Gly Leu 
    1100                 1105                 1110             


Gln Gly  Met Asn Gly Ser Ile  Gln Ala Lys Ser Ile  Gln Val Leu 
    1115                 1120                 1125             


Pro Ser  His Glu Leu Val Ser  Thr Arg Ile Ala Glu  His Leu Gly 
    1130                 1135                 1140             


Asp Ser  Gln Ser Leu Gly Arg  Met Leu Ala Asp Tyr  Arg Ala Arg 
    1145                 1150                 1155             


Gly Gly  Arg Ile Gln Pro Lys  Asn Ser Asp Pro Phe  Ala His Ser 
    1160                 1165                 1170             


Lys Asp  Ala Ser Ser Thr Ser  Ser Gly Gln Ser Gly  Ser Lys Asn 
    1175                 1180                 1185             


Glu Gly  Asp Glu Glu Arg Gly  Leu Ile Leu Ser Asp  Ala Val Trp 
    1190                 1195                 1200             


Ser Thr  Lys Val Asp Cys Leu  Asn Pro Ile Asn His  Gln Arg Leu 
    1205                 1210                 1215             


Cys Val  Leu Phe Ser Ser Ser  Ser Ala Gln Ser Ser  Asn Ala Pro 
    1220                 1225                 1230             


Ser Ala  Cys Val Ser Pro Trp  Ile Val Thr Met Glu  Phe Tyr Gly 
    1235                 1240                 1245             


Lys Asn  Asp Leu Thr Leu Gly  Ile Phe Leu Glu Arg  Tyr Cys Phe 
    1250                 1255                 1260             


Arg Pro  Ser Tyr Gln Cys Pro  Ser Met Phe Cys Asp  Thr Pro Met 
    1265                 1270                 1275             


Val His  His Ile Arg Arg Phe  Val His Gly Gln Gly  Cys Val Gln 
    1280                 1285                 1290             


Ile Ile  Leu Lys Glu Leu Asp  Ser Pro Val Pro Gly  Tyr Gln His 
    1295                 1300                 1305             


Thr Ile  Leu Thr Tyr Ser Trp  Cys Arg Ile Cys Lys  Gln Val Thr 
    1310                 1315                 1320             


Pro Val  Val Ala Leu Ser Asn  Glu Ser Trp Ser Met  Ser Phe Ala 
    1325                 1330                 1335             


Lys Tyr  Leu Glu Leu Arg Phe  Tyr Gly His Gln Tyr  Thr Arg Arg 
    1340                 1345                 1350             


Ala Asn  Ala Glu Pro Cys Gly  His Ser Ile His His  Asp Tyr His 
    1355                 1360                 1365             


Gln Tyr  Phe Ser Tyr Asn Gln  Met Val Ala Ser Phe  Ser Tyr Ser 
    1370                 1375                 1380             


Pro Ile  Arg Leu Leu Glu Val  Cys Val Pro Leu Pro  Lys Ile Phe 
    1385                 1390                 1395             


Ile Lys  Arg Gln Ala Pro Leu  Lys Val Ser Leu Leu  Gln Asp Leu 
    1400                 1405                 1410             


Lys Asp  Phe Phe Gln Lys Val  Ser Gln Val Tyr Val  Ala Ile Asp 
    1415                 1420                 1425             


Glu Arg  Leu Ala Ser Leu Lys  Thr Asp Thr Phe Ser  Lys Thr Arg 
    1430                 1435                 1440             


Glu Glu  Lys Met Glu Asp Ile  Phe Ala Gln Lys Glu  Met Glu Glu 
    1445                 1450                 1455             


Gly Glu  Phe Lys Asn Trp Ile  Glu Lys Met Gln Ala  Arg Leu Met 
    1460                 1465                 1470             


Ser Ser  Ser Val Asp Thr Pro  Gln Gln Leu Gln Ser  Val Phe Glu 
    1475                 1480                 1485             


Ser Leu  Ile Ala Lys Lys Gln  Ser Leu Cys Glu Val  Leu Gln Ala 
    1490                 1495                 1500             


Trp Asn  Asn Arg Leu Gln Asp  Leu Phe Gln Gln Glu  Lys Gly Arg 
    1505                 1510                 1515             


Lys Arg  Pro Ser Val Pro Pro  Ser Pro Gly Arg Leu  Arg Gln Gly 
    1520                 1525                 1530             


Glu Glu  Ser Lys Ile Ser Ala  Met Asp Ala Ser Pro  Arg Asn Ile 
    1535                 1540                 1545             


Ser Pro  Gly Leu Gln Asn Gly  Glu Lys Glu Asp Arg  Phe Leu Thr 
    1550                 1555                 1560             


Thr Leu  Ser Ser Gln Ser Ser  Thr Ser Ser Thr His  Leu Gln Leu 
    1565                 1570                 1575             


Pro Thr  Pro Pro Glu Val Met  Ser Glu Gln Ser Val  Gly Gly Pro 
    1580                 1585                 1590             


Pro Glu  Leu Asp Thr Ala Ser  Ser Ser Glu Asp Val  Phe Asp Gly 
    1595                 1600                 1605             


His Leu  Leu Gly Ser Thr Asp  Ser Gln Val Lys Glu  Lys Ser Thr 
    1610                 1615                 1620             


Met Lys  Ala Ile Phe Ala Asn  Leu Leu Pro Gly Asn  Ser Tyr Asn 
    1625                 1630                 1635             


Pro Ile  Pro Phe Pro Phe Asp  Pro Asp Lys His Tyr  Leu Met Tyr 
    1640                 1645                 1650             


Glu His  Glu Arg Val Pro Ile  Ala Val Cys Glu Lys  Glu Pro Ser 
    1655                 1660                 1665             


Ser Ile  Ile Ala Phe Ala Leu  Ser Cys Lys Glu Tyr  Arg Asn Ala 
    1670                 1675                 1680             


Leu Glu  Glu Leu Ser Lys Ala  Thr Gln Trp Asn Ser  Ala Glu Glu 
    1685                 1690                 1695             


Gly Leu  Pro Thr Asn Ser Thr  Ser Asp Ser Arg Pro  Lys Ser Ser 
    1700                 1705                 1710             


Ser Pro  Ile Arg Leu Pro Glu  Met Ser Gly Gly Gln  Thr Asn Arg 
    1715                 1720                 1725             


Thr Thr  Glu Thr Glu Pro Gln  Pro Thr Lys Lys Ala  Ser Gly Met 
    1730                 1735                 1740             


Leu Ser  Phe Phe Arg Gly Thr  Ala Gly Lys Ser Pro  Asp Leu Ser 
    1745                 1750                 1755             


Ser Gln  Lys Arg Glu Thr Leu  Arg Gly Ala Asp Ser  Ala Tyr Tyr 
    1760                 1765                 1770             


Gln Val  Gly Gln Thr Gly Lys  Glu Gly Thr Glu Asn  Gln Gly Val 
    1775                 1780                 1785             


Glu Pro  Gln Asp Glu Val Asp  Gly Gly Asp Thr Gln  Lys Lys Gln 
    1790                 1795                 1800             


Leu Ile  Asn Pro His Val Glu  Leu Gln Phe Ser Asp  Ala Asn Ala 
    1805                 1810                 1815             


Lys Phe  Tyr Cys Arg Leu Tyr  Tyr Ala Gly Glu Phe  His Lys Met 
    1820                 1825                 1830             


Arg Glu  Val Ile Leu Asp Ser  Ser Glu Glu Asp Phe  Ile Arg Ser 
    1835                 1840                 1845             


Leu Ser  His Ser Ser Pro Trp  Gln Ala Arg Gly Gly  Lys Ser Gly 
    1850                 1855                 1860             


Ala Ala  Phe Tyr Ala Thr Glu  Asp Asp Arg Phe Ile  Leu Lys Gln 
    1865                 1870                 1875             


Met Pro  Arg Leu Glu Val Gln  Ser Phe Leu Asp Phe  Ala Pro His 
    1880                 1885                 1890             


Tyr Phe  Asn Tyr Ile Thr Asn  Ala Val Gln Gln Lys  Arg Pro Thr 
    1895                 1900                 1905             


Ala Leu  Ala Lys Ile Leu Gly  Val Tyr Arg Ile Gly  Tyr Lys Asn 
    1910                 1915                 1920             


Ser Gln  Asn Asn Thr Glu Lys  Lys Leu Asp Leu Leu  Val Met Glu 
    1925                 1930                 1935             


Asn Leu  Phe Tyr Gly Arg Lys  Met Ala Gln Val Phe  Asp Leu Lys 
    1940                 1945                 1950             


Gly Ser  Leu Arg Asn Arg Asn  Val Lys Thr Asp Thr  Gly Lys Glu 
    1955                 1960                 1965             


Ser Cys  Asp Val Val Leu Leu  Asp Glu Asn Leu Leu  Lys Met Val 
    1970                 1975                 1980             


Arg Asp  Asn Pro Leu Tyr Ile  Arg Ser His Ser Lys  Ala Val Leu 
    1985                 1990                 1995             


Arg Thr  Ser Ile His Ser Asp  Ser His Phe Leu Ser  Ser His Leu 
    2000                 2005                 2010             


Ile Ile  Asp Tyr Ser Leu Leu  Val Gly Arg Asp Asp  Thr Ser Asn 
    2015                 2020                 2025             


Glu Leu  Val Val Gly Ile Ile  Asp Tyr Ile Arg Thr  Phe Thr Trp 
    2030                 2035                 2040             


Asp Lys  Lys Leu Glu Met Val  Val Lys Ser Thr Gly  Ile Leu Gly 
    2045                 2050                 2055             


Gly Gln  Gly Lys Met Pro Thr  Val Val Ser Pro Glu  Leu Tyr Arg 
    2060                 2065                 2070             


Thr Arg  Phe Cys Glu Ala Met  Asp Lys Tyr Phe Leu  Met Val Pro 
    2075                 2080                 2085             


Asp His  Trp Thr Gly Leu Gly  Leu Asn Cys 
    2090                 2095             


<210>  22
<211>  9901
<212>  DNA
<213>  Homo sapiens

<400>  22
caaccatgta agcagcttcg cttcctgccg caaccgtccg cggcctgagg agcccaccgc       60

cgctctcggg ggccgacttc cgggggctga gccgttgaag cggaggctgg ggcggggggc      120

agccggcgcg gccggggcag gaggcgcaga ctcatgaaat ggccacagat gataagacgt      180

ccccaacact ggactctgct aatgatttgc ctcgatctcc tactagtcct tctcatctca      240

cacactttaa acctttgact cctgatcaag atgagccccc ttttaaatca gcttatagtt      300

cttttgtaaa tctctttcgt tttaacaaag agagagcaga aggaggccag ggagaacagc      360

agcctttgag tggaagttgg accagccctc agctcccttc gaggacacag tctgttaggt      420

cacccacacc ttataaaaag cagcttaatg aggaactcca gcggcgctct tcagcattag      480

acacaagaag gaaagcagaa cctacctttg gaggtcatga ccctcgtaca gctgttcagc      540

ttcgaagcct cagcacagta ttaaaacgcc tcaaggaaat catggagggg aaaagccagg      600

atagtgacct gaaacaatac tggatgccag atagccaatg taaagagtgc tatgactgta      660

gtgagaaatt tacaaccttt aggcgcagac accattgccg actatgtggg cagattttct      720

gcagtcgttg ctgtaatcaa gaaatccctg gaaaatttat gggctataca ggagacctcc      780

gagcttgcac atattgtaga aaaatagcct taagttatgc tcattccaca gacagtaatt      840

ctattgggga agacttgaat gctctttcag attctgcttg ctctgtgtct gtgcttgatc      900

caagtgaacc ccgaacacct gttgggagta ggaaagccag ccgtaacata tttttagagg      960

atgatttggc ctggcaaagt ttgattcatc cagattcctc aaatactcct ctttcaacaa     1020

gacttgtatc tgtgcaagag gatgctggga aatctcctgc tcgaaataga tcagccagca     1080

ttactaacct gtcactggat agatctggtt ctcctatggt accttcatat gagacatctg     1140

tcagtcccca ggctaaccga acatatgtta ggacagagac cactgaggat gaacgcaaaa     1200

ttcttctgga cagtgtgcag ttaaaagacc tgtggaaaaa aatctgccat cacagcagtg     1260

gaatggagtt tcaggatcac cgctactggt tgagaacgca tcccaactgc attgtaggaa     1320

aggaattagt caactggcta atccgaaatg ggcatattgc cacaagggca caagctatag     1380

caattggaca agcaatggtt gatggacgtt ggctggattg tgttagtcat cacgaccagc     1440

ttttcagaga tgagtatgcg ctgtatagac cactgcagag tacagaattt tctgagacgc     1500

cttctcccga cagtgactca gtgaactccg tggaaggaca ctctgagcca tcctggttta     1560

aagacataaa gtttgatgac agtgacacag aacagatagc tgaagaaggt gacgataatt     1620

tggctaattc tgccagtcct agcaagcgca catcagtcag cagtttccag tccacagtgg     1680

acagtgactc agccgcttct atcagcctga acgtggagct ggacaacgtg aacttccata     1740

tcaagaagcc ctccaagtac ccacatgtgc cccctcaccc tgctgaccaa aaagagtatt     1800

tgatttctga cactggagga caacagctct caataagtga cgctttcatc aaagaatcct     1860

tatttaatcg ccgagtagag gaaaaatcca aagagctgcc tttcacacct ttgggctggc     1920

atcataacaa cctggagctc ctgagggagg agaatgggga gaaacaagcc atggagaggt     1980

tgctttcagc taatcataac cacatgatgg cactactcca gcagttgctc catagtgact     2040

cactgtcatc atcttggagg gacatcatcg tgtcattggt ctgccaggtt gttcagacag     2100

tccgacctga tgtcaagaac caggatgatg acatggatat ccgtcagttt gtccacatca     2160

aaaaaatccc aggtggaaag aagtttgatt ctgtggttgt caatggcttt gtttgtacca     2220

agaacattgc acataaaaag atgagttctt gtattaaaaa ccccaaaatt cttctgttga     2280

agtgttccat tgagtatctc tacagagaag aaactaagtt tacttgcatt gatcctattg     2340

tgcttcagga aagggaattc ttgaagaatt atgtccagcg aatagttgat gttcgaccca     2400

ccttggttct tgttgagaaa acagtgtctc ggattgccca ggacatgtta ttggaacatg     2460

gcattacttt ggtcattaat gtaaagtcac aagttttgga acgaatcagt cgaatgaccc     2520

aaggtgattt agtgatgtca atggaccagc tgcttacgaa accacacctg ggcacttgtc     2580

acaaatttta tatgcagata tttcagttgc ctaatgaaca aaccaagaca ctgatgtttt     2640

ttgaaggttg tccacagcac ctaggctgta caatcaagct aagaggaggc tctgattatg     2700

agctggctcg agttaaggag atcctaatat ttatgatctg tgttgcttat cattctcaac     2760

tagaaatatc ctttctcatg gatgaatttg ctatgcctcc cacattaatg caaaaccctt     2820

cattccattc cctgattgag ggacgagggc atgagggggc tgtccaagag cagtacggtg     2880

gaggttccat cccctgggat cctgacatcc ctcctgagtc tctgccctgt gatgatagca     2940

gtttgctgga attgaggatt gtgtttgaga agggtgagca ggaaaataaa aatcttccgc     3000

aggctgttgc ctctgtgaag catcaagaac atagcacaac agcttgcccg gcgggtctcc     3060

cttgtgcttt ctttgcacct gtaccggaat cattgttgcc actccctgtg gatgaccaac     3120

aagatgcttt aggcagcgag cagccagaga ctttgcagca aacagttgtg ctgcaggatc     3180

ccaaaagcca gataagagcc tttagagacc ctctacagga tgacactgga ttatatgtta     3240

ctgaggaagt cacctcctct gaagataaac gaaagactta ttctttggcc tttaagcagg     3300

aattaaaaga tgtgatcctc tgtatctccc cagtaatcac attccgagaa ccctttcttt     3360

taactgaaaa ggggatgaga tgctctaccc gagattattt tgcagagcag gtttactggt     3420

ctcctctcct caataaagaa ttcaaagaaa tggagaacag gaggaagaaa cagctgctca     3480

gggatctctc tggacttcag ggcatgaatg gaagtattca ggccaagtct attcaagtct     3540

taccctcaca tgagctagtg agcactagaa ttgctgagca tctgggcgat agccagagct     3600

tgggtagaat gctggccgat tatcgagcca gaggaggaag aattcagccc aaaaattcag     3660

acccttttgc tcattcaaag gatgcatcaa gtacttcaag tggccaatca ggaagcaaaa     3720

atgagggtga tgaagagaga gggcttattc tgagtgatgc tgtgtggtca acaaaggtgg     3780

actgtctgaa tcccattaat caccagagac tttgtgtgct cttcagcagc tcttctgccc     3840

agtccagcaa tgctcctagt gcctgtgtca gtccttggat tgtaacaatg gaattttatg     3900

gaaagaatga tcttacatta ggaatatttt tagagagata ctgtttcagg ccttcttatc     3960

agtgtccaag catgttctgt gataccccca tggtacatca tattcggcgc tttgttcatg     4020

gccaaggctg tgtgcagata atcctgaagg agttggattc tccagtacct ggatatcagc     4080

atacaattct tacatattcc tggtgtagaa tctgcaaaca ggtaacacca gttgttgctc     4140

tttccaatga gtcctggtct atgtcatttg caaaatacct tgaacttagg ttttatgggc     4200

accagtatac tcgcagagcc aacgctgagc cctgtggtca ctccatccat catgattatc     4260

accagtattt ctcctataac cagatggtgg cgtctttcag ttattctccc attcggcttc     4320

ttgaagtatg tgttccactc cccaaaatat tcattaagcg tcaggcccca ttaaaagtgt     4380

cccttcttca ggatctgaag gacttctttc aaaaagtttc acaggtatat gttgccattg     4440

atgaaagact tgcatctttg aaaactgata catttagtaa aacaagagag gaaaaaatgg     4500

aagatatttt tgcacagaaa gagatggaag aaggtgagtt caagaactgg attgagaaga     4560

tgcaagcaag gctcatgtct tcctctgtag atacccctca gcaactgcag tcggtctttg     4620

agtcactcat tgccaagaaa caaagtctct gtgaagtgct gcaagcttgg aataacaggt     4680

tgcaggacct tttccaacag gaaaagggta gaaagagacc ttcagttcct ccaagtcctg     4740

gaagactgag acaaggggaa gaaagcaaga taagtgcgat ggatgcatct ccacggaata     4800

tttctccagg acttcagaat ggagaaaaag aggatcgctt cttaacaact ttgtccagcc     4860

agagctccac cagttctact catctccaat tgcctacgcc acctgaagtc atgtctgaac     4920

agtcagtggg agggccccct gagctagata cagccagcag ttccgaagat gtgtttgatg     4980

ggcatttgct gggatccaca gacagccaag tgaaggaaaa gtcaaccatg aaagccatct     5040

ttgcaaattt gcttccagga aatagctata atcctattcc atttcctttt gatccagata     5100

aacactactt aatgtatgaa catgaacgag tgcccattgc agtctgcgag aaggaaccca     5160

gctccatcat tgcttttgct ctcagttgta aagaataccg aaatgcctta gaggaattgt     5220

ctaaagcgac tcagtggaac agtgccgaag aagggcttcc aacaaatagt acttcagata     5280

gcagaccaaa gagtagcagc cctatcagat tacctgaaat gagtggagga cagacaaatc     5340

gtacaacaga aacagaacca caaccaacca aaaaggcttc tggaatgttg tccttcttca     5400

gagggacagc agggaaaagc cccgatctct cttcccagaa gagagagacc ttacgtggag     5460

cagatagtgc ttactaccag gttgggcaga cgggcaagga ggggaccgag aatcaaggcg     5520

ttgagcctca agatgaagta gatggaggag atacacaaaa gaagcaactc ataaatcctc     5580

atgtggaact tcaattttca gatgctaatg ccaagtttta ctgtcggctc tactatgcgg     5640

gagagtttca taagatgcgt gaagtgattc tggacagcag tgaagaagat ttcattcgtt     5700

ccctctccca ctcatcaccc tggcaggccc ggggaggcaa atcaggagct gccttctatg     5760

caactgagga tgatagattt attttgaagc aaatgcctcg tctggaagtc cagtccttcc     5820

tcgactttgc accacattac ttcaattata ttacaaatgc tgttcaacaa aagaggccca     5880

cggcgttggc caaaattctt ggagtttaca gaattggtta taagaactct cagaacaaca     5940

ctgagaagaa gttagatctc cttgtcatgg aaaatctttt ctacgggaga aagatggcac     6000

aggtttttga tttgaagggc tctcttagga atcggaatgt aaaaactgac actggaaaag     6060

agagttgtga tgtggtcctg ctagatgaaa atctcctaaa gatggttcga gacaaccctc     6120

tatatattcg ttctcattcc aaagctgtgc tgagaacctc gatccatagt gactcccatt     6180

tcctttctag ccacctcatt atagattatt ctttgctggt tgggcgagat gatactagca     6240

atgagctagt agttggaatt atagattata ttcgaacatt tacatgggac aaaaagcttg     6300

agatggttgt gaaatcaaca ggaattttag gtggacaagg taaaatgcca acagtggtgt     6360

ctccggagtt gtacaggact aggttttgtg aggcaatgga caagtatttc ctaatggtac     6420

cagaccactg gacaggcttg ggtctgaatt gctgaaatca agcacatatt ttgaaatgga     6480

ctgtgaagga aaaggggaca ggaacaaagg accaaaaata agctacatgt tttatttctt     6540

catcgtgttc accactgtat gccaaggctt ttcagttctg tggctgttta gactgtccgt     6600

aatggaatgg taaaactcca tgaatttgca ctttggtttt tgatacctgt ggagctgtct     6660

gtaggttggg aagtggcatg aaaattttct taagctaaaa tacagacatg tttcaaaggg     6720

ctaaagttgg agatgagtag atagggtgaa aaatgggtta aatttgctag cttaattgtt     6780

ttaagaagaa aacagtgtct cataaattga ctatcctggc atcacattta acatgttatc     6840

tacttagaaa gcatttgtag agctgctgaa tttgttttgt gtttttctgt aataatttaa     6900

tgttacttat tatcagaatt tctgaaacct ttacaaaaat tctgatttat tccattaatg     6960

gccagttaaa cacgtgggca tttattgttt tattgaggaa tttgacttaa actgggaatc     7020

ctgtcatgtt gtttatcttt ccagcttgcc tgtttttgag tatgtttgat gtttttaaaa     7080

ttttgtcttc tctgtggatg acaggaggct acagcaatta actttaagcc tccttttaga     7140

gatattttta aagcttgttt aaaatttttg tgcaattcat atattaaatt gcacttactt     7200

gcatacgctc atattctagg gttttttctc tatttttagg gtatcatagt aaatcattag     7260

taaatgagtc tgtagttact aaaccctaat ggaataatta ttaatgaaag atttttgaaa     7320

tataaaaaat aaattaggcc caatccaaga aattgagtga gaaggaaaca cttgttttat     7380

tcacagaggt aaagtgtctt ttcaatataa ccagcaattt aggtggcatc tataaaataa     7440

aaaatttcta ctgtggacat ccccttttcc aactttctac ataatggcta gttctgacta     7500

ctaagaaatg ttaagaaata ggccaagtgc ggtggctcac gcctataatc ctatcacttt     7560

gggaggccta ggcaggcaga tcacctgagg tcaggagttc aagaccagcc tggccaacat     7620

gaggaaaccc catctctact aaaaagacaa aaaattagct gggcatggtg gcatatacct     7680

gtaaccccaa ctacttgggt ggctgaggca ggagaattgt ttgaacctgg gaggcggagg     7740

ctgcagtgag ctgggattac accattgcat tccagcctgg gcaacagagc aagactgtct     7800

caaaaaacaa aacgaaacaa aaaaagaaag ttattcttag taaggaactt cttgtttaat     7860

agcatttttg tttattttaa aaagtgatca gaagtagtaa actatctttg aggaaatact     7920

gtaaccccag aatatttcct cttgacttct ttttgtaaca aggataattt agggatttat     7980

aaagttgtaa ggatttcact gttttcggac tgcctataat aatagcacat taaccttcac     8040

ataataagaa atctggacaa gttcagttac acagtatgat gaatacttga attaggaaca     8100

ttgtggaaaa tttgctttag agaatcaagg cagtagtttg gtatttggtg cttattaaaa     8160

atgtggtttg ttttgaactg gaagcaagtt gaccaaggac ttatgactaa tgtgatgcta     8220

agttccactt ggcccctttt aaaaacgtgt atgtgccttt tgaagataca caaaacactg     8280

aggattttag ttttgaaatc aaagactatt aaaggagctg tacagaggta aaaaaataaa     8340

tgtggaacat tattaactta ttttgtgtct aggaacaatg gattttgtat ctgatttaaa     8400

atgccaacac tgttttgtct ctgttcattt tttctgtgag gatacttaag gttattattc     8460

ctgtctgttt cctgtactcc cctagtcatg agcacttgaa gtacaaggtg tctcccccta     8520

ggtgcaatta ggttgtttct ttgtttttag tttcaattct atgtgcatag caggaatgct     8580

ccacaggaat ggcttctgac aataatctgt cctgttgatt ttgttttcct tgcccatgac     8640

ttgaacaact gtgttttaaa gtactgtagt ctagtaggta actttgtggc aaaaattttc     8700

aatataatac attctgaaac aatagttgct gccttgcaaa ggtaatctct cattttaaaa     8760

ttggacagta ttaatgaagg ggaaatatac aatttatttc tattgagtgg tagaactata     8820

tgtctggtcc cttgctgctc ttgtttaggc cactatcata gatatatttc aaatattgta     8880

ctactcagtg ttaagtattg aatgactgtt tccctttcct tcaaggccta gagtatattc     8940

tgaaaattta ggaatgagga agaaatctta atacttcctt ccttaacata caacatgagt     9000

cccgagaata attgatagta gcaagagaaa actatgtcag taacatgttg ctttgtataa     9060

aaatcttatt tataaatgtg aagctttttg atgccatcaa aacttattaa aaaataggat     9120

ttactttttt ctaattctga cctaagaaaa ataatgagaa caagctgttg caagctcttt     9180

tgtagtctat tgaatatttt atagatattc aaaatttcct acaaactata attttttcca     9240

tgatttagca gtgagtgatt ttctagcttt ggctcttatt aggtattgta aatagtaggg     9300

ttatatcgat atcagctttt gtgatggcat tgtggtcatc agcttcatga cattttaccc     9360

atttgcagtg atcctgtgta aaactgccaa ggaaagtaat tacctgtagg agtttgctga     9420

gcttgaagag tgaaaactgt tgtgaatgag cctgatcata aaacggacca ggccattcat     9480

tattcctcaa gtgttaatat actgacttat gcagtattca aaccatctag tgcaatgttt     9540

ttgtttttgt tttttttttg gtaacacagg tgcagtgtat tatagaaaaa ataaaaacta     9600

caatcattag cagttttaat actgctgtgt cagttttgta aaaaatgtac attatgtctt     9660

ttgacatgtt gaattttaaa ctagggaaat gacattgtaa atcatagtag cctcttttaa     9720

tttaatatga aaaatgccac tatattgaaa gtacttaatg tattgtatat atttctctac     9780

tttggttcta gctattttat atgattgaca tgttatttaa aagataactg ccttgaactt     9840

ttggagactt gtactgtaaa taaagaaatc ttaacaataa actcagaatc tacttactcc     9900

a                                                                     9901


<210>  23
<211>  907
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Pro Thr Ala Ala Ala Pro Ile Ile Ser Ser Val Gln Lys Leu Val 
1               5                   10                  15      


Leu Tyr Glu Thr Arg Ala Arg Tyr Phe Leu Val Gly Ser Asn Asn Ala 
            20                  25                  30          


Glu Thr Lys Tyr Arg Val Leu Lys Ile Asp Arg Thr Glu Pro Lys Asp 
        35                  40                  45              


Leu Val Ile Ile Asp Asp Arg His Val Tyr Thr Gln Gln Glu Val Arg 
    50                  55                  60                  


Glu Leu Leu Gly Arg Leu Asp Leu Gly Asn Arg Thr Lys Met Gly Gln 
65                  70                  75                  80  


Lys Gly Ser Ser Gly Leu Phe Arg Ala Val Ser Ala Phe Gly Val Val 
                85                  90                  95      


Gly Phe Val Arg Phe Leu Glu Gly Tyr Tyr Ile Val Leu Ile Thr Lys 
            100                 105                 110         


Arg Arg Lys Met Ala Asp Ile Gly Gly His Ala Ile Tyr Lys Val Glu 
        115                 120                 125             


Asp Thr Asn Met Ile Tyr Ile Pro Asn Asp Ser Val Arg Val Thr His 
    130                 135                 140                 


Pro Asp Glu Ala Arg Tyr Leu Arg Ile Phe Gln Asn Val Asp Leu Ser 
145                 150                 155                 160 


Ser Asn Phe Tyr Phe Ser Tyr Ser Tyr Asp Leu Ser His Ser Leu Gln 
                165                 170                 175     


Tyr Asn Leu Thr Val Leu Arg Met Pro Leu Glu Met Leu Lys Ser Glu 
            180                 185                 190         


Met Thr Gln Asn Arg Gln Glu Ser Phe Asp Ile Phe Glu Asp Glu Gly 
        195                 200                 205             


Leu Ile Thr Gln Gly Gly Ser Gly Val Phe Gly Ile Cys Ser Glu Pro 
    210                 215                 220                 


Tyr Met Lys Tyr Val Trp Asn Gly Glu Leu Leu Asp Ile Ile Lys Ser 
225                 230                 235                 240 


Thr Val His Arg Asp Trp Leu Leu Tyr Ile Ile His Gly Phe Cys Gly 
                245                 250                 255     


Gln Ser Lys Leu Leu Ile Tyr Gly Arg Pro Val Tyr Val Thr Leu Ile 
            260                 265                 270         


Ala Arg Arg Ser Ser Lys Phe Ala Gly Thr Arg Phe Leu Lys Arg Gly 
        275                 280                 285             


Ala Asn Cys Glu Gly Asp Val Ala Asn Glu Val Glu Thr Glu Gln Ile 
    290                 295                 300                 


Leu Cys Asp Ala Ser Val Met Ser Phe Thr Ala Gly Ser Tyr Ser Ser 
305                 310                 315                 320 


Tyr Val Gln Val Arg Gly Ser Val Pro Leu Tyr Trp Ser Gln Asp Ile 
                325                 330                 335     


Ser Thr Met Met Pro Lys Pro Pro Ile Thr Leu Asp Gln Ala Asp Pro 
            340                 345                 350         


Phe Ala His Val Ala Ala Leu His Phe Asp Gln Met Phe Gln Arg Phe 
        355                 360                 365             


Gly Ser Pro Ile Ile Ile Leu Asn Leu Val Lys Glu Arg Glu Lys Arg 
    370                 375                 380                 


Lys His Glu Arg Ile Leu Ser Glu Glu Leu Val Ala Ala Val Thr Tyr 
385                 390                 395                 400 


Leu Asn Gln Phe Leu Pro Pro Glu His Thr Ile Val Tyr Ile Pro Trp 
                405                 410                 415     


Asp Met Ala Lys Tyr Thr Lys Ser Lys Leu Cys Asn Val Leu Asp Arg 
            420                 425                 430         


Leu Asn Val Ile Ala Glu Ser Val Val Lys Lys Thr Gly Phe Phe Val 
        435                 440                 445             


Asn Arg Pro Asp Ser Tyr Cys Ser Ile Leu Arg Pro Asp Glu Lys Trp 
    450                 455                 460                 


Asn Glu Leu Gly Gly Cys Val Ile Pro Thr Gly Arg Leu Gln Thr Gly 
465                 470                 475                 480 


Ile Leu Arg Thr Asn Cys Val Asp Cys Leu Asp Arg Thr Asn Thr Ala 
                485                 490                 495     


Gln Phe Met Val Gly Lys Cys Ala Leu Ala Tyr Gln Leu Tyr Ser Leu 
            500                 505                 510         


Gly Leu Ile Asp Lys Pro Asn Leu Gln Phe Asp Thr Asp Ala Val Arg 
        515                 520                 525             


Leu Phe Glu Glu Leu Tyr Glu Asp His Gly Asp Thr Leu Ser Leu Gln 
    530                 535                 540                 


Tyr Gly Gly Ser Gln Leu Val His Arg Val Lys Thr Tyr Arg Lys Ile 
545                 550                 555                 560 


Ala Pro Trp Thr Gln His Ser Lys Asp Ile Met Gln Thr Leu Ser Arg 
                565                 570                 575     


Tyr Tyr Ser Asn Ala Phe Ser Asp Ala Asp Arg Gln Asp Ser Ile Asn 
            580                 585                 590         


Leu Phe Leu Gly Val Phe His Pro Thr Glu Gly Lys Pro His Leu Trp 
        595                 600                 605             


Glu Leu Pro Thr Asp Phe Tyr Leu His His Lys Asn Thr Met Arg Leu 
    610                 615                 620                 


Leu Pro Thr Arg Arg Ser Tyr Thr Tyr Trp Trp Thr Pro Glu Val Ile 
625                 630                 635                 640 


Lys His Leu Pro Leu Pro Tyr Asp Glu Val Ile Cys Ala Val Asn Leu 
                645                 650                 655     


Lys Lys Leu Ile Val Lys Lys Phe His Lys Tyr Glu Glu Glu Ile Asp 
            660                 665                 670         


Ile His Asn Glu Phe Phe Arg Pro Tyr Glu Leu Ser Ser Phe Asp Asp 
        675                 680                 685             


Thr Phe Cys Leu Ala Met Thr Ser Ser Ala Arg Asp Phe Met Pro Lys 
    690                 695                 700                 


Thr Val Gly Ile Asp Pro Ser Pro Phe Thr Val Arg Lys Pro Asp Glu 
705                 710                 715                 720 


Thr Gly Lys Ser Val Leu Gly Asn Lys Ser Asn Arg Glu Glu Ala Val 
                725                 730                 735     


Leu Gln Arg Lys Thr Ala Ala Ser Ala Pro Pro Pro Pro Ser Glu Glu 
            740                 745                 750         


Ala Val Ser Ser Ser Ser Glu Asp Asp Ser Gly Thr Asp Arg Glu Glu 
        755                 760                 765             


Glu Gly Ser Val Ser Gln Arg Ser Thr Pro Val Lys Met Thr Asp Ala 
    770                 775                 780                 


Gly Asp Ser Ala Lys Val Thr Glu Asn Val Val Gln Pro Met Lys Glu 
785                 790                 795                 800 


Leu Tyr Gly Ile Asn Leu Ser Asp Gly Leu Ser Glu Glu Asp Phe Ser 
                805                 810                 815     


Ile Tyr Ser Arg Phe Val Gln Leu Gly Gln Ser Gln His Lys Gln Asp 
            820                 825                 830         


Lys Asn Ser Gln Gln Pro Cys Ser Arg Cys Ser Asp Gly Val Ile Lys 
        835                 840                 845             


Leu Thr Pro Ile Ser Ala Phe Ser Gln Asp Asn Ile Tyr Glu Val Gln 
    850                 855                 860                 


Pro Pro Arg Val Asp Arg Lys Ser Thr Glu Ile Phe Gln Ala His Ile 
865                 870                 875                 880 


Gln Ala Ser Gln Gly Ile Met Gln Pro Leu Gly Lys Glu Asp Ser Ser 
                885                 890                 895     


Met Tyr Arg Glu Tyr Ile Arg Asn Arg Tyr Leu 
            900                 905         


<210>  24
<211>  3123
<212>  DNA
<213>  Homo sapiens

<400>  24
acgtcctcca gccccgctcc cgacgtgagg ggcggggctt gcctggaggc ggggcgcagg       60

gatccggaaa cacctgatca tctataggtt tagtgcctaa tgggtgttgt tcctggctgg      120

acttgatgtc cagggcctga ggggttttct cgccgagtct cctggggcgg tccggaggct      180

cgtgccctgt tgtggggccc ccatttgccg ccgccatgcc cacggccgcc gcccccatca      240

tcagctcggt ccagaagctg gttctgtatg agactagagc tagatacttt ctagttggga      300

gcaataatgc agaaacgaaa tatcgtgtct tgaagattga tagaacagaa ccaaaagatt      360

tggtcataat tgatgacagg catgtctata ctcaacaaga agtaagggaa cttcttggcc      420

gcttggatct tggaaataga acaaagatgg gacagaaagg atcctcgggc ttatttcgag      480

cggtttcagc ttttggtgtt gtgggttttg tcaggttctt agaaggctat tatattgtgt      540

taataactaa aaggaggaag atggcggata ttggaggtca tgcaatctat aaggtcgaag      600

atacaaatat gatctatata cccaatgatt ctgtacgggt tactcatcct gatgaagcta      660

ggtatctacg aatatttcaa aatgtggacc tatctagcaa tttttacttt agttacagct      720

atgatttgtc ccactcactt caatataatc tcactgtctt gcgaatgccc ctggagatgt      780

taaagtcaga aatgacccag aatcgccaag agagctttga catctttgaa gatgaaggat      840

taattacaca aggtggaagc ggggtatttg ggatctgtag tgagccttat atgaaatatg      900

tatggaatgg tgaacttctg gatataatta aaagtactgt gcatcgtgac tggcttttgt      960

atattattca tgggttctgt gggcagtcaa agctgttgat ctatggacga ccagtgtatg     1020

tcactctaat agctagaaga tccagtaaat ttgctggcac ccgttttctt aaaagaggtg     1080

caaactgtga gggtgatgtt gcaaatgaag tggagactga acaaatactc tgcgatgctt     1140

ctgtgatgtc tttcactgca ggaagttatt cttcatatgt acaagttaga ggatctgtgc     1200

ccttatactg gtctcaggac atttcaacta tgatgcctaa accacctatt acattggatc     1260

aggcagatcc atttgcacat gtggctgccc ttcactttga ccagatgttc cagaggtttg     1320

gctctcccat catcatcttg aatttagtga aggaacgaga gaaaagaaag catgaaagaa     1380

ttctgagtga agaacttgtt gctgctgtga cctatctcaa ccaatttttg cctcctgagc     1440

acactattgt ttatattccc tgggacatgg ccaagtatac caaaagcaag ctgtgtaatg     1500

ttcttgatcg actaaatgtg attgcagaaa gtgtggtgaa gaaaacaggt ttctttgtaa     1560

accgccctga ttcttactgt agcattttgc ggccagatga aaagtggaat gaactaggag     1620

gatgtgtgat tcccactggt cgcctgcaga ctggcatcct tcgaaccaac tgtgtggact     1680

gtttagatcg caccaacaca gcacagttta tggtgggaaa atgtgctctg gcctatcagc     1740

tgtattcact gggactgatt gacaaaccta atctacagtt tgatacagat gcagttaggt     1800

tatttgagga actctatgaa gatcatggtg ataccctatc ccttcagtat ggtggttctc     1860

aacttgttca tcgtgtgaaa acctacagaa agatagcacc atggacccag cactccaaag     1920

acatcatgca aaccctgtct agatattaca gcaatgcttt ttcagatgcc gatagacaag     1980

attccattaa tctcttcctg ggagttttcc atcccactga agggaaacct catctctggg     2040

agctcccaac agatttttat ttgcatcaca aaaataccat gagacttttg ccaacaagaa     2100

gaagttatac ttactggtgg acaccagagg tgataaagca tttaccattg ccctatgatg     2160

aagttatctg tgctgtgaac ttaaagaagt tgatagtgaa gaaattccac aaatatgaag     2220

aagagattga tatccacaat gagttctttc ggccatatga gttgagcagc tttgatgata     2280

ccttttgctt ggctatgaca agctcagcac gtgactttat gcctaagacc gttggaattg     2340

atccaagtcc atttactgtg cgtaaaccag atgaaactgg aaaatcagta ttgggaaaca     2400

aaagcaatag agaagaagct gtattacagc ggaaaacggc agccagcgcc ccgccgcccc     2460

ccagcgagga ggctgtgtcc agcagctctg aggatgactc tgggactgat cgggaagaag     2520

agggctctgt gtctcagcgc tccactcccg tgaagatgac tgatgcagga gacagtgcca     2580

aagtgaccga gaatgtggtc caacccatga aggagctata tggaattaac ctctcagatg     2640

gcctctcaga agaagatttc tccatttatt caagatttgt tcagctgggg cagagtcaac     2700

ataaacaaga caagaatagc cagcagccct gttctaggtg ctcagatgga gttataaaac     2760

taacacccat ctcggctttc tcgcaagata acatctatga agttcagccc ccaagagtag     2820

acagaaaatc tacagagatc ttccaagccc acatccaggc cagccaaggt atcatgcagc     2880

ccctaggaaa agaggactcc tccatgtacc gagagtacat caggaaccgc tacctgtgaa     2940

aagagcgcag gtccacctgg tggacacgtc tgattagctt agaacctgtc ttgtctcatc     3000

ttcaaaaggt aacttattaa aagtcctttg cgtctgaagc ctttctcctt ttctgtcact     3060

tgcaaattcc aaattatagc taataaagat gactagataa tttgcaaaaa aaaaaaaaaa     3120

aaa                                                                   3123


<210>  25
<211>  1491
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Asn Gly Val Ala Phe Cys Leu Val Gly Ile Pro Pro Arg Pro Glu 
1               5                   10                  15      


Pro Arg Pro Pro Gln Leu Pro Leu Gly Pro Arg Asp Gly Cys Ser Pro 
            20                  25                  30          


Arg Arg Pro Phe Pro Trp Gln Gly Pro Arg Thr Leu Leu Leu Tyr Lys 
        35                  40                  45              


Ser Pro Gln Asp Gly Phe Gly Phe Thr Leu Arg His Phe Ile Val Tyr 
    50                  55                  60                  


Pro Pro Glu Ser Ala Val His Cys Ser Leu Lys Glu Glu Glu Asn Gly 
65                  70                  75                  80  


Gly Arg Gly Gly Gly Pro Ser Pro Arg Tyr Arg Leu Glu Pro Met Asp 
                85                  90                  95      


Thr Ile Phe Val Lys Asn Val Lys Glu Asp Gly Pro Ala His Arg Ala 
            100                 105                 110         


Gly Leu Arg Thr Gly Asp Arg Leu Val Lys Val Asn Gly Glu Ser Val 
        115                 120                 125             


Ile Gly Lys Thr Tyr Ser Gln Val Ile Ala Leu Ile Gln Asn Ser Asp 
    130                 135                 140                 


Asp Thr Leu Glu Leu Ser Ile Met Pro Lys Asp Glu Asp Ile Leu Gln 
145                 150                 155                 160 


Leu Ala Tyr Ser Gln Asp Ala Tyr Leu Lys Gly Asn Glu Pro Tyr Ser 
                165                 170                 175     


Gly Glu Ala Arg Ser Ile Pro Glu Pro Pro Pro Ile Cys Tyr Pro Arg 
            180                 185                 190         


Lys Thr Tyr Ala Pro Pro Ala Arg Ala Ser Thr Arg Ala Thr Met Val 
        195                 200                 205             


Pro Glu Pro Thr Ser Ala Leu Pro Ser Asp Pro Arg Ser Pro Ala Ala 
    210                 215                 220                 


Trp Ser Asp Pro Gly Leu Arg Val Pro Pro Ala Ala Arg Ala His Leu 
225                 230                 235                 240 


Asp Asn Ser Ser Leu Gly Met Ser Gln Pro Arg Pro Ser Pro Gly Ala 
                245                 250                 255     


Phe Pro His Leu Ser Ser Glu Pro Arg Thr Pro Arg Ala Phe Pro Glu 
            260                 265                 270         


Pro Gly Ser Arg Val Pro Pro Ser Arg Leu Glu Cys Gln Gln Ala Leu 
        275                 280                 285             


Ser His Trp Leu Ser Asn Gln Val Pro Arg Arg Ala Gly Glu Arg Arg 
    290                 295                 300                 


Cys Pro Ala Met Ala Pro Arg Ala Arg Ser Ala Ser Gln Asp Arg Leu 
305                 310                 315                 320 


Glu Glu Val Ala Ala Pro Arg Pro Trp Pro Cys Ser Thr Ser Gln Asp 
                325                 330                 335     


Ala Leu Ser Gln Leu Gly Gln Glu Gly Trp His Arg Ala Arg Ser Asp 
            340                 345                 350         


Asp Tyr Leu Ser Arg Ala Thr Arg Ser Ala Glu Ala Leu Gly Pro Gly 
        355                 360                 365             


Ala Leu Val Ser Pro Arg Phe Glu Arg Cys Gly Trp Ala Ser Gln Arg 
    370                 375                 380                 


Ser Ser Ala Arg Thr Pro Ala Cys Pro Thr Arg Asp Leu Pro Gly Pro 
385                 390                 395                 400 


Gln Ala Pro Pro Pro Ser Gly Leu Gln Gly Leu Asp Asp Leu Gly Tyr 
                405                 410                 415     


Ile Gly Tyr Arg Ser Tyr Ser Pro Ser Phe Gln Arg Arg Thr Gly Leu 
            420                 425                 430         


Leu His Ala Leu Ser Phe Arg Asp Ser Pro Phe Gly Gly Leu Pro Thr 
        435                 440                 445             


Phe Asn Leu Ala Gln Ser Pro Ala Ser Phe Pro Pro Glu Ala Ser Glu 
    450                 455                 460                 


Pro Pro Arg Val Val Arg Pro Glu Pro Ser Thr Arg Ala Leu Glu Pro 
465                 470                 475                 480 


Pro Ala Glu Asp Arg Gly Asp Glu Val Val Leu Arg Gln Lys Pro Pro 
                485                 490                 495     


Thr Gly Arg Lys Val Gln Leu Thr Pro Ala Arg Gln Met Asn Leu Gly 
            500                 505                 510         


Phe Gly Asp Glu Ser Pro Glu Pro Glu Ala Ser Gly Arg Gly Glu Arg 
        515                 520                 525             


Leu Gly Arg Lys Val Ala Pro Leu Ala Thr Thr Glu Asp Ser Leu Ala 
    530                 535                 540                 


Ser Ile Pro Phe Ile Asp Glu Pro Thr Ser Pro Ser Ile Asp Leu Gln 
545                 550                 555                 560 


Ala Lys His Val Pro Ala Ser Ala Val Val Ser Ser Ala Met Asn Ser 
                565                 570                 575     


Ala Pro Val Leu Gly Thr Ser Pro Ser Ser Pro Thr Phe Thr Phe Thr 
            580                 585                 590         


Leu Gly Arg His Tyr Ser Gln Asp Cys Ser Ser Ile Lys Ala Gly Arg 
        595                 600                 605             


Arg Ser Ser Tyr Leu Leu Ala Ile Thr Thr Glu Arg Ser Lys Ser Cys 
    610                 615                 620                 


Asp Asp Gly Leu Asn Thr Phe Arg Asp Glu Gly Arg Val Leu Arg Arg 
625                 630                 635                 640 


Leu Pro Asn Arg Ile Pro Ser Leu Arg Met Leu Arg Ser Phe Phe Thr 
                645                 650                 655     


Asp Gly Ser Leu Asp Ser Trp Gly Thr Ser Glu Asp Ala Asp Ala Pro 
            660                 665                 670         


Ser Lys Arg His Ser Thr Ser Asp Leu Ser Asp Ala Thr Phe Ser Asp 
        675                 680                 685             


Ile Arg Arg Glu Gly Trp Leu Tyr Tyr Lys Gln Ile Leu Thr Lys Lys 
    690                 695                 700                 


Gly Lys Lys Ala Gly Ser Gly Leu Arg Gln Trp Lys Arg Val Tyr Ala 
705                 710                 715                 720 


Ala Leu Arg Ala Arg Ser Leu Ser Leu Ser Lys Glu Arg Arg Glu Pro 
                725                 730                 735     


Gly Pro Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala Gly Glu Asp Glu 
            740                 745                 750         


Ala Ala Pro Val Cys Ile Gly Ser Cys Leu Val Asp Ile Ser Tyr Ser 
        755                 760                 765             


Glu Thr Lys Arg Arg His Val Phe Arg Leu Thr Thr Ala Asp Phe Cys 
    770                 775                 780                 


Glu Tyr Leu Phe Gln Ala Glu Asp Arg Asp Asp Met Leu Gly Trp Ile 
785                 790                 795                 800 


Arg Ala Ile Arg Glu Asn Ser Arg Ala Glu Gly Glu Asp Pro Gly Cys 
                805                 810                 815     


Ala Asn Gln Ala Leu Ile Ser Lys Lys Leu Asn Asp Tyr Arg Lys Val 
            820                 825                 830         


Ser His Ser Ser Gly Pro Lys Ala Asp Ser Ser Pro Lys Gly Ser Arg 
        835                 840                 845             


Gly Leu Gly Gly Leu Lys Ser Glu Phe Leu Lys Gln Ser Ala Ala Arg 
    850                 855                 860                 


Gly Leu Arg Thr Gln Asp Leu Pro Ala Gly Ser Lys Asp Asp Ser Ala 
865                 870                 875                 880 


Ala Ala Pro Lys Thr Pro Trp Gly Ile Asn Ile Ile Lys Lys Asn Lys 
                885                 890                 895     


Lys Ala Ala Pro Arg Ala Phe Gly Val Arg Leu Glu Glu Cys Gln Pro 
            900                 905                 910         


Ala Thr Glu Asn Gln Arg Val Pro Leu Ile Val Ala Ala Cys Cys Arg 
        915                 920                 925             


Ile Val Glu Ala Arg Gly Leu Glu Ser Thr Gly Ile Tyr Arg Val Pro 
    930                 935                 940                 


Gly Asn Asn Ala Val Val Ser Ser Leu Gln Glu Gln Leu Asn Arg Gly 
945                 950                 955                 960 


Pro Gly Asp Ile Asn Leu Gln Asp Glu Arg Trp Gln Asp Leu Asn Val 
                965                 970                 975     


Ile Ser Ser Leu Leu Lys Ser Phe Phe Arg Lys Leu Pro Glu Pro Leu 
            980                 985                 990         


Phe Thr Asp Asp Lys Tyr Asn Asp  Phe Ile Glu Ala Asn  Arg Ile Glu 
        995                 1000                 1005             


Asp Ala  Arg Glu Arg Met Arg  Thr Leu Arg Lys Leu  Ile Arg Asp 
    1010                 1015                 1020             


Leu Pro  Gly His Tyr Tyr Glu  Thr Leu Lys Phe Leu  Val Gly His 
    1025                 1030                 1035             


Leu Lys  Thr Ile Ala Asp His  Ser Glu Lys Asn Lys  Met Glu Pro 
    1040                 1045                 1050             


Arg Asn  Leu Ala Leu Val Phe  Gly Pro Thr Leu Val  Arg Thr Ser 
    1055                 1060                 1065             


Glu Asp  Asn Met Thr Asp Met  Val Thr His Met Pro  Asp Arg Tyr 
    1070                 1075                 1080             


Lys Ile  Val Glu Thr Leu Ile  Gln His Ser Asp Trp  Phe Phe Ser 
    1085                 1090                 1095             


Asp Glu  Glu Asp Lys Gly Glu  Arg Thr Pro Val Gly  Asp Lys Glu 
    1100                 1105                 1110             


Pro Gln  Ala Val Pro Asn Ile  Glu Tyr Leu Leu Pro  Asn Ile Gly 
    1115                 1120                 1125             


Arg Thr  Val Pro Pro Gly Asp  Pro Gly Ser Asp Ser  Thr Thr Cys 
    1130                 1135                 1140             


Ser Ser  Ala Lys Ser Lys Gly  Ser Trp Ala Pro Lys  Lys Glu Pro 
    1145                 1150                 1155             


Tyr Ala  Arg Glu Met Leu Ala  Ile Ser Phe Ile Ser  Ala Val Asn 
    1160                 1165                 1170             


Arg Lys  Arg Lys Lys Arg Arg  Glu Ala Arg Gly Leu  Gly Ser Ser 
    1175                 1180                 1185             


Thr Asp  Asp Asp Ser Glu Gln  Glu Ala His Lys Pro  Gly Ala Gly 
    1190                 1195                 1200             


Ala Thr  Ala Pro Gly Thr Gln  Glu Arg Pro Gln Gly  Pro Leu Pro 
    1205                 1210                 1215             


Gly Ala  Val Ala Pro Glu Ala  Pro Gly Arg Leu Ser  Pro Pro Ala 
    1220                 1225                 1230             


Ala Pro  Glu Glu Arg Pro Ala  Ala Asp Thr Arg Ser  Ile Val Ser 
    1235                 1240                 1245             


Gly Tyr  Ser Thr Leu Ser Thr  Met Asp Arg Ser Val  Cys Ser Gly 
    1250                 1255                 1260             


Ala Ser  Gly Arg Arg Ala Gly  Ala Gly Asp Glu Ala  Asp Asp Glu 
    1265                 1270                 1275             


Arg Ser  Glu Leu Ser His Val  Glu Thr Asp Thr Glu  Gly Ala Ala 
    1280                 1285                 1290             


Gly Ala  Gly Pro Gly Gly Arg  Leu Thr Arg Arg Pro  Ser Phe Ser 
    1295                 1300                 1305             


Ser His  His Leu Met Pro Cys  Asp Thr Leu Ala Arg  Arg Arg Leu 
    1310                 1315                 1320             


Ala Arg  Gly Arg Pro Asp Gly  Glu Gly Ala Gly Arg  Gly Gly Pro 
    1325                 1330                 1335             


Arg Ala  Pro Glu Pro Pro Gly  Ser Ala Ser Ser Ser  Ser Gln Glu 
    1340                 1345                 1350             


Ser Leu  Arg Pro Pro Ala Ala  Ala Leu Ala Ser Arg  Pro Ser Arg 
    1355                 1360                 1365             


Met Glu  Ala Leu Arg Leu Arg  Leu Arg Gly Thr Ala  Asp Asp Met 
    1370                 1375                 1380             


Leu Ala  Val Arg Leu Arg Arg  Pro Leu Ser Pro Glu  Thr Arg Arg 
    1385                 1390                 1395             


Arg Arg  Ser Ser Trp Arg Arg  His Thr Val Val Val  Gln Ser Pro 
    1400                 1405                 1410             


Leu Thr  Asp Leu Asn Phe Asn  Glu Trp Lys Glu Leu  Gly Gly Gly 
    1415                 1420                 1425             


Gly Pro  Pro Glu Pro Ala Gly  Ala Arg Ala His Ser  Asp Asn Lys 
    1430                 1435                 1440             


Asp Ser  Gly Leu Ser Ser Leu  Glu Ser Thr Lys Ala  Arg Ala Pro 
    1445                 1450                 1455             


Ser Ser  Ala Ala Ser Gln Pro  Pro Ala Pro Gly Asp  Thr Gly Ser 
    1460                 1465                 1470             


Leu Gln  Ser Gln Pro Pro Arg  Arg Ser Ala Ala Ser  Arg Leu His 
    1475                 1480                 1485             


Gln Cys  Leu 
    1490     


<210>  26
<211>  5913
<212>  DNA
<213>  Homo sapiens

<400>  26
ctgccacccg atgaatggag tcgccttctg cctggtcggg atcccgcccc gcccggagcc       60

ccggccccca cagctgccac tgggcccaag agatgggtgc tctcctaggc gccccttccc      120

ctggcagggg ccgaggacgc tgctgctgta caaaagtccc caggacggct ttggcttcac      180

tctgcgccac ttcatcgtgt acccacccga gtcggccgtg cactgcagcc tgaaggagga      240

agagaatgga ggccgtggag gaggaccctc cccccggtac cgcctggagc ccatggacac      300

catctttgtc aagaatgtga aggaagacgg ccctgcccat agggcggggc ttcgcacagg      360

agaccggctg gtaaaggtga atggggaaag cgtcattggg aagacctact ctcaggtcat      420

agctctgatc cagaatagtg atgacactct ggagctgtct atcatgccca aggacgagga      480

catcctccag ctggcctact cccaggatgc ctacctgaaa gggaacgagc cgtattctgg      540

agaggcccgc agcatcccag agccaccgcc gatctgctac ccccgcaaga cctacgcccc      600

tcctgcccgg gcctccacca gggccactat ggtgcctgag cccacctcag cactgcccag      660

tgacccccgg agtcctgctg cctggagtga cccggggctc cgtgtgccac ctgctgcccg      720

tgcccacctg gacaactctt ccttggggat gagccagccc cgccccagcc ctggtgcctt      780

cccccacctc tcctcggagc cccggacgcc ccgtgccttc ccagagcctg gcagccgggt      840

gccccccagc agactggagt gccagcaggc cttgtcacac tggctgtcaa accaggtacc      900

ccgccgggcg ggggagagac ggtgcccagc catggccccc cgggcccgca gcgcctccca      960

ggaccggttg gaggaggtgg ctgccccccg cccgtggccc tgctccacct cccaggatgc     1020

tttgagccag ctgggccagg agggctggca ccgagctcgc tcagatgact acttgagccg     1080

ggccacccgt tctgccgagg cactggggcc aggggcactg gtgtcacccc gctttgagcg     1140

gtgtggctgg gcttcccagc gttcgtctgc ccgcaccccc gcctgcccaa ctcgggacct     1200

gccagggccc caggccccac ccccgtctgg cctgcagggc ctggatgacc tcgggtacat     1260

cggctaccgg agctacagcc catcattcca gcgccggacc ggcctcctcc atgcgctctc     1320

cttccgggac tcaccctttg gggggctgcc taccttcaac ctggcccagt cccctgcgtc     1380

attcccacca gaggcctccg agccacccag ggttgtacgg ccggaaccca gcacccgggc     1440

cctggagcct cctgcggagg atcgcggcga tgaggtggtc ctgaggcaga agcccccgac     1500

gggccgcaag gttcagctga cccccgcaag acagatgaac cttggatttg gtgacgagtc     1560

cccagagcca gaggccagtg ggcgagggga acgcctgggc aggaaggtgg cccctttggc     1620

caccaccgaa gactctctgg cttccatccc ctttattgat gagcccacca gccccagcat     1680

tgacctccaa gccaagcacg tccctgcctc tgctgtggtc tccagtgcca tgaactcagc     1740

ccctgtcctg ggcaccagcc catcttcccc gaccttcact ttcaccctcg gacgccatta     1800

ctcgcaggac tgcagcagca tcaaggctgg ccgccgctcc tcctacctgc tggccatcac     1860

cacggagcgc tccaagtcct gcgatgatgg actcaacacc ttccgcgacg agggccgggt     1920

tctgcggcgc ctgccaaacc gcatacccag cctgcggatg ctccggagct tcttcaccga     1980

cgggtccttg gatagctggg gcacctctga agatgctgac gctccttcta agcgacactc     2040

aacctctgac ctctcagatg cgaccttcag cgatatcagg agagaaggct ggttgtatta     2100

taagcagatt ctcaccaaga aggggaagaa agcgggcagc ggcctgcgcc agtggaagcg     2160

ggtgtacgcc gcgctgcggg cgcgctcgct ctcgctgagc aaggagcggc gggagcccgg     2220

gccggcggcg gcgggggctg cggcggccgg cgcaggtgag gacgaggcgg cgcccgtctg     2280

catcggctcc tgcctcgtgg acatctccta cagcgagacc aagaggaggc acgtgttccg     2340

gctgaccacc gctgacttct gtgaatatct ctttcaggct gaggaccggg atgacatgct     2400

gggctggatc agagcgatcc gggagaacag cagggccgag ggcgaggacc ccggctgtgc     2460

caaccaagct ctgatcagca agaagcttaa cgattatcgc aaagtgagcc atagctctgg     2520

gcccaaagct gattcctccc ccaaaggctc tcgcggcctg gggggcctca agtctgagtt     2580

cctcaagcag agtgcggcac gtggcctcag gactcaggac ctgcccgcag ggagcaagga     2640

tgacagtgct gcagccccca aaaccccctg gggcatcaac atcatcaaga aaaataagaa     2700

ggccgctccg agggcgtttg gggtcaggct ggaggagtgc cagccagcca cggagaacca     2760

gcgcgtcccc ttaatcgtgg ctgcatgctg tcgcattgtg gaggcacgag ggctggagtc     2820

cacaggcatt taccgagtgc ccggcaacaa tgcagtggtg tccagcctac aggagcagct     2880

caaccgcggg cctggtgaca tcaacctgca ggatgagcgc tggcaagacc tcaatgtgat     2940

cagcagcctg ctcaagtcct tcttccgaaa gctgcccgag cctcttttca ctgatgacaa     3000

atacaacgac ttcatcgagg ccaaccgcat tgaggacgcg cgggagcgaa tgaggacgct     3060

gcggaagctg atccgggatc tcccaggaca ctactatgaa acgctcaaat tccttgtggg     3120

ccatctcaag accatcgctg accactctga gaaaaacaag atggaacccc ggaacctggc     3180

cctggtcttt gggccgacac tggtgaggac gtctgaggac aacatgacag acatggtgac     3240

ccacatgcct gaccgctaca agatcgtgga gacactgatc cagcactcag actggttctt     3300

cagtgacgaa gaggacaagg gagagagaac ccctgtgggc gacaaggagc ctcaggcagt     3360

gcccaacatt gagtacctcc tgcccaacat tggcaggaca gtgccccctg gcgacccggg     3420

gtcagattct accacctgta gttcagccaa gtccaagggt tcgtgggccc ccaagaagga     3480

gccgtacgcc cgggagatgc tggcgatctc cttcatctcg gccgtcaacc gcaagcgcaa     3540

gaagcggcgg gaggcgcggg ggctgggcag cagcaccgac gacgactcgg agcaggaggc     3600

gcacaagcct ggggcggggg ccacagcgcc ggggactcag gagcggccgc aggggccgct     3660

gcctggcgcc gtcgcccccg aggcccccgg acgcctcagt cccccggcgg cgccggagga     3720

gcggccggcc gcggacacgc gctccattgt gtcgggctac tccaccctgt ccaccatgga     3780

ccgcagcgtg tgctcgggcg ctagcggtcg gcgggcaggg gcgggggatg aggcggacga     3840

cgagcgtagc gagctgagcc acgtggagac ggacactgag ggcgcggcgg gcgcggggcc     3900

tggggggcgc ctgacacgcc ggccgtcctt cagctcgcac cacctcatgc cctgcgacac     3960

tctggcgcgc cgccgcctgg cccggggccg cccagacggc gagggcgcgg gccggggcgg     4020

tccccgcgcc ccggagccgc ccggctcggc gtcgtccagc agccaggagt cgctgcggcc     4080

cccggcggcg gcgctggcct cccggccctc gcgcatggag gcgctgcgtc taaggctccg     4140

cggcacggcg gacgacatgc tcgccgtgcg cctgcggcgg ccgctgtcgc ccgagacccg     4200

gcggcgccgg agcagctggc gccgccacac cgtggtggtg cagagcccgc tgactgacct     4260

caacttcaac gagtggaagg agctgggcgg agggggcccc ccggagcctg cgggcgcgcg     4320

ggcgcacagt gacaacaagg actccggact cagcagcctg gagtccacca aggcgcgggc     4380

cccgtcgtcc gctgcctcgc agccgcccgc gcccggggac acggggtccc tgcagagcca     4440

gcccccgcgc cgctcggccg cctcccgcct gcatcagtgt ctgtgatccc cacctcccgc     4500

gccgctcggg cgccacccct ccctagagcc cctttggaac caggaggctt caccagcctg     4560

cacctcctct tctgtggccc ctgggtgcat ggtgtgggtg gagggcgcag caggcagtgt     4620

ctctagttgg tgtgctggaa ctggcagggc agaggagaag gctggggccg gactaattga     4680

atggaagggg gttccagagg tgatgagcag aagaggaggg ggcgtgggct gctggggtct     4740

gtgtccctgc acacatgcgc ccgataggtc cttctgagcc tttctgtggc tgcacttggg     4800

gacccttgtg gaccatgggg tgtggctagg gaacccctaa gtttcagact aaaggaaaga     4860

tcctgggtga tgctggcttt ttgcttcttt cttctgccct cccacctcag cttgtaagcg     4920

gggatgtgtg tatgtctggg gagaggaggt gtagggtgcg tatgtccatg gggggagggg     4980

cttgtgtgtg cagtcattgt cccaaggtgt ttccagtagc gacttctgtc cccctatccc     5040

caccctggtc cccactttgc gcccccgggc tccctgcctt tggtgcacac aggatcctgc     5100

ccgcccccct tgccagagcc agagaagggg gttggggcca ttccaaggag gcaggactga     5160

aaccctcacc agggttactc cccaacatcc ttttgcctga gtcaccctct aagcgcttta     5220

accacgggca gctgcctgtt ccccagacag tttttggtgg ggggggtcca gggtccccct     5280

tgctggtacc tccctcaccc ctctttttgt ttttccatct gtgcctgttc cttccacagc     5340

ccaggcacac agaagcccac cttcttcccc ttaggaggag ggatagtcaa cacccctgct     5400

gtctctctgt cactcacaca ctgatttatg gggtctgagc tgggctgttc ctgcaggatg     5460

gacaggaccc agcgccctct tctccccaca ggctgtaaat agacttccaa tcaccaggcc     5520

agcccccaca caccctcact cattccaggg aagcccaggt aggtggtgaa cccgctgcca     5580

cgtctatcag tcctcttgtt ttatgcaaag atttactgta aagtagattt ctttccctcc     5640

ctcccccatt cttttattgt aaatattgtc tctaaatgtg taacatatta taaagaattt     5700

ataaggattt ttaaagatgt tttgctcatt tacaaaagtg ttgtaacagt gttggacaaa     5760

gccttccacc ccatgtccgc atggctcctt tcactgtgtc cttgacacac ctctctggca     5820

acaactaaaa tttcctgctt ctgaaaagtc ctgtcttaaa agtacagtct atatcttgga     5880

aataaatagc tttcctcaag gcatgaaaaa aaa                                  5913


<210>  27
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  NPC-F1 primer

<400>  27
gaagttggtc tggcgatgga g                                                 21


<210>  28
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  NPC1-R2 primer

<400>  28
aaggtcctga tctaaaactc tag                                               23


<210>  29
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  VPS33A-F1 primer

<400>  29
tgtcctacgg ccgagtgaac c                                                 21


<210>  30
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  VPS33A-R1 primer

<400>  30
ctgtacactt tgctcagttt cc                                                22


<210>  31
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  VPS11-F1 primer

<400>  31
gaaggagccg ctgagcaatg atg                                               23


<210>  32
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  VPS11-R1 primer

<400>  32
ggccagaatt tagtagcagc aac                                               23


<210>  33
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  PGT-F1 primer

<400>  33
tctccaaatc tcggtggaac                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  VPS11 primer

<400>  34
ctgcttccaa gttcctttgc                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  VPS11 primer

<400>  35
aagattcgag tgcagagtgg                                                   20


<210>  36
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  NPC1 primer

<400>  36
ccacagcatg accgctc                                                      17


<210>  37
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  NPC1 primer

<400>  37
cagctcacaa aacaggttca g                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  VPS33A primer

<400>  38
ttaacacctc ttgccactca g                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  VPS33A primer

<400>  39
tgtgtctttc ctcgaatgct g                                                 21


