                               SEQUENCE LISTING	

<110> JOULE UNLIMITED TECHNOLOGIES, INC.
 
<120> METHODS AND COMPOSITIONS FOR PRODUCING ALKENES OF VARIOUS CHAIN 
      LENGTH

<130> 26139-20073PCT

<140>
<141>

<150> 61/441,619
<151> 2011-02-10

<160> 40    

<170> PatentIn version 3.5

<210> 1
<211> 8163
<212> DNA
<213> Synechococcus sp.

<400> 1
atggttggtc aatttgcaaa tttcgtcgat ctgctccagt acagagctaa acttcaggcg       60

cggaaaaccg tgtttagttt tctggctgat ggcgaagcgg aatctgcggc cctgacctac      120

ggagaattag accaaaaagc ccaggcgatc gccgcttttt tgcaagctaa ccaggctcaa      180

gggcaacggg cattattact ttatccaccg ggtttagagt ttatcggtgc ctttttggga      240

tgtttgtatg ctggtgttgt tgcggtgcca gcttacccac cacggccgaa taaatccttt      300

gaccgcctcc atagcattat ccaagatgcc caggcaaaat ttgccctcac cacaacagaa      360

cttaaagata aaattgccga tcgcctcgaa gctttagaag gtacggattt tcattgtttg      420

gctacagatc aagttgaatt aatttcagga aaaaattggc aaaaaccgaa catttccggc      480

acagatctcg cttttttgca atacaccagt ggctccacgg gcgatcctaa aggagtgatg      540

gtttcccacc acaatttgat ccacaactcc ggcttgatta accaaggatt ccaggataca      600

gaggcgagta tgggcgtttc ctggttgccg ccctaccatg atatgggctt gatcggtggg      660

attttacagc ccatctatgt gggagcaacg caaattttaa tgcctcccgt ggcctttttg      720

cagcgacctt ttcggtggct aaaggcgatc aacgattatc gggtttccac cagcggtgcg      780

ccgaattttg cctatgatct ctgtgccagc caaattaccc cggaacaaat cagagaactc      840

gatttgagct gttggcgact ggctttttcc ggggccgaac cgatccgcgc tgtgaccctc      900

gaaaattttg cgaaaacctt cgctacagca ggctttcaaa aatcagcatt ttatccctgt      960

tatggtatgg ctgaaaccac cctgatcgtt tccggtggta atggtcgtgc ccagcttccc     1020

caggaaatta tcgtcagcaa acagggcatc gaagcaaacc aagttcgccc tgcccaaggg     1080

acagaaacaa cggtgacctt ggtcggcagt ggtgaagtga ttggcgacca aattgtcaaa     1140

attgttgacc cccaggcttt aacagaatgt accgtcggtg aaattggcga agtatgggtt     1200

aagggcgaaa gtgttgccca gggctattgg caaaagccag acctcaccca gcaacaattc     1260

cagggaaacg tcggtgcaga aacgggcttt ttacgcacgg gcgatctggg ttttttgcaa     1320

ggtggcgaac tgtatattac gggtcgttta aaggatctcc tgattatccg ggggcgcaac     1380

cactatcccc aggacattga attaaccgtc gaagtggccc atcccgcttt acgacagggg     1440

gccggagccg ctgtatcagt agacgttaac ggggaagaac agttagtcat tgtccaggaa     1500

gttgagcgta aatatgcccg caaattaaat gtcgcggcag tagcccaagc tattcgtggg     1560

gcgatcgccg ccgaacatca actgcaaccc caggccattt gttttattaa acccggtagc     1620

attcccaaaa catccagcgg gaagattcgt cgccatgcct gcaaagctgg ttttctagac     1680

ggaagcttgg ctgtggttgg ggagtggcaa cccagccacc aaaaagaagg aaaaggaatt     1740

gggacacaag ccgttacccc ttctacgaca acatcaacga attttcccct gcctgaccag     1800

caccaacagc aaattgaagc ctggcttaag gataatattg cccatcgcct cggcattacg     1860

ccccaacaat tagacgaaac ggaacccttt gcaagttatg ggctggattc agtgcaagca     1920

gtacaggtca cagccgactt agaggattgg ctaggtcgaa aattagaccc cactctggcc     1980

tacgattatc cgaccattcg caccctggct cagtttttgg tccagggtaa tcaagcgcta     2040

gagaaaatac cacaggtgcc gaaaattcag ggcaaagaaa ttgccgtggt gggtctcagt     2100

tgtcgttttc cccaagctga caaccccgaa gctttttggg aattattacg taatggtaaa     2160

gatggagttc gcccccttaa aactcgctgg gccacgggag aatggggtgg ttttttagaa     2220

gatattgacc agtttgagcc gcaatttttt ggcatttccc cccgggaagc ggaacaaatg     2280

gatccccagc aacgcttact gttagaagta acctgggaag ccttggaacg ggcaaatatt     2340

ccggcagaaa gtttacgcca ttcccaaacg ggggtttttg tcggcattag taatagtgat     2400

tatgcccagt tgcaggtgcg ggaaaacaat ccgatcaatc cctacatggg gacgggcaac     2460

gcccacagta ttgctgcgaa tcgtctgtct tatttcctcg atctccgggg cgtttctctg     2520

agcatcgata cggcctgttc ctcttctctg gtggcggtac atctggcctg tcaaagttta     2580

atcaacggcg aatcggagtt ggcgatcgcc gccggggtga atttgatttt gacccccgat     2640

gtgacccaga cttttaccca ggcgggcatg atgagtaaga cgggccgttg ccagaccttt     2700

gatgccgagg ctgatggcta tgtgcggggc gaaggttgtg gggtcgttct cctcaaaccc     2760

ctggcccagg cagaacggga cggggataat attctcgcgg tgatccacgg ttcggcggtg     2820

aatcaagatg gacgcagtaa cggtttgacg gctcccaacg ggcgatcgca acaggccgtt     2880

attcgccaag ccctggccca agccggcatt accgccgccg atttagctta cctagaggcc     2940

cacggcaccg gcacgcccct gggtgatccc attgaaatta attccctgaa ggcggtttta     3000

caaacggcgc agcgggaaca gccctgtgtg gtgggttctg tgaaaacaaa cattggtcac     3060

ctcgaggcag cggcgggcat cgcgggctta atcaaggtga ttttgtccct agagcatgga     3120

atgattcccc aacatttgca ttttaagcag ctcaatcccc gcattgatct agacggttta     3180

gtgaccattg cgagcaaaga tcagccttgg tcaggcgggt cacaaaaacg gtttgctggg     3240

gtaagttcct ttgggtttgg tggcaccaat gcccacgtga ttgtcgggga ctatgctcaa     3300

caaaaatctc cccttgctcc tccggctacc caagaccgcc cttggcattt gctgaccctt     3360

tctgctaaaa atgcccaggc cttaaatgcc ctgcaaaaaa gctatggaga ctatctggcc     3420

caacatccca gcgttgaccc acgcgatctc tgtttgtctg ccaataccgg gcgatcgccc     3480

ctcaaagaac gtcgtttttt tgtctttaaa caagtcgccg atttacaaca aactctcaat     3540

caagattttc tggcccaacc acgcctcagt tcccccgcaa aaattgcctt tttgtttacg     3600

gggcaaggtt cccaatacta cggcatgggg caacaactgt accaaaccag cccagtattt     3660

cggcaagtgc tggatgagtg cgatcgcctc tggcagacct attcccccga agcccctgcc     3720

ctcaccgacc tgctgtacgg taaccataac cctgacctcg tccacgaaac tgtctatacc     3780

cagcccctcc tctttgctgt tgaatatgcg atcgcccaac tatggttaag ctggggcgtg     3840

acgccagact tttgcatggg ccatagcgtc ggcgaatatg tcgcggcttg tctggcgggg     3900

gtattttccc tggcagacgg catgaaatta attacggccc ggggcaaact gatgcacgcc     3960

ctacccagca atggcagtat ggcggcggtc tttgccgata aaacggtcat caaaccctac     4020

ctatcggagc atttgaccgt cggagccgaa aacggttccc atttggtgct atcaggaaag     4080

accccctgcc tcgaagccag tattcacaaa ctccaaagcc aagggatcaa aaccaaaccc     4140

ctcaaggttt cccatgcttt ccactcccct ttgatggctc ccatgctggc agagtttcgg     4200

gaaattgctg aacaaattac tttccacccg ccgcgtatcc cgctcatttc caatgtcacg     4260

ggcggccaga ttgaagcgga aattgcccag gccgactatt gggttaagca cgtttcgcaa     4320

cccgtcaaat ttgtccagag catccaaacc ctggcccaag cgggtgtcaa tgtttatctc     4380

gaaatcggcg taaaaccagt gctcctgagt atgggacgcc attgcttagc tgaacaagaa     4440

gcggtttggt tgcccagttt acgtccccat agtgagcctt ggccggaaat tttgaccagt     4500

ctcggcaaac tgtatgagca agggctaaac attgactggc agaccgtgga agctggcgat     4560

cgccgccgga aactgattct gcccacctat cccttccaac ggcaacgata ttggtttaat     4620

caaggctctt ggcaaactgt tgagaccgaa tctgtgaacc caggccctga cgatctcaat     4680

gattggttgt atcaggtggc gtggacgccc ctggacactt tgcccccggc ccctgaaccg     4740

tcggctaagc tgtggttaat cttgggcgat cgccatgatc accagcccat tgaagcccaa     4800

tttaaaaacg cccagcgggt gtatctcggc caaagcaatc attttccgac gaatgccccc     4860

tgggaagtat ctgccgatgc gttggataat ttatttactc acgtcggctc ccaaaattta     4920

gcaggcatcc tttacctgtg tcccccaggg gaagacccag aagacctaga tgaaattcaa     4980

aagcaaacca gtggcttcgc cctccaactg atccaaaccc tgtatcaaca aaagatcgcg     5040

gttccctgct ggtttgtgac ccaccagagc caacgggtgc ttgaaaccga tgctgtcacc     5100

ggatttgccc aagggggatt atggggactc gcccaggcga tcgccctcga acatccagag     5160

ttgtgggggg gaattattga tgtcgatgac agcctgccaa attttgccca gatttgccaa     5220

caaagacagg tgcagcagtt ggccgtgcgg caccaaaaac tctacggggc acagctcaaa     5280

aagcaaccgt cactgcccca gaaaaatctc cagattcaac cccaacagac ctatctagtg     5340

acagggggac tgggggccat tggccgtaaa attgcccaat ggctagccgc agcaggagca     5400

gaaaaagtaa ttctcgtcag ccggcgcgct ccggcagcgg atcagcagac gttaccgacc     5460

aatgcggtgg tttatccttg cgatttagcc gacgcagccc aggtggcaaa gctgtttcaa     5520

acctatcccc acatcaaagg aattttccat gcggcgggta ccttagctga tggtttgctg     5580

caacaacaaa cttggcaaaa gttccagacc gtcgccgccg ccaaaatgaa agggacatgg     5640

catctgcacc gccatagtca aaagctcgat ctggattttt ttgtgttgtt ttcctctgtg     5700

gcaggggtgc tcggttcacc gggacagggg aattatgccg ccgcaaaccg gggcatggcg     5760

gcgatcgccc aatatcgaca agcccaaggt ttacccgccc tggcgatcca ttgggggcct     5820

tgggccgaag ggggaatggc caactccctc agcaaccaaa atttagcgtg gctgccgccc     5880

ccccagggac taacaatcct cgaaaaagtc ttgggcgccc agggggaaat gggggtcttt     5940

aaaccggact ggcaaaacct ggccaaacag ttccccgaat ttgccaaaac ccattacttt     6000

gcagccgtta ttccctctgc tgaggctgtg cccccaacgg cttcaatttt tgacaaatta     6060

atcaacctag aagcttctca gcgggctgac tatctactgg attatctgcg gcggtctgtg     6120

gcgcaaatcc tcaagttaga aattgagcaa attcaaagcc acgatagcct gttggatctg     6180

ggcatggatt cgttgatgat catggaggcg atcgccagcc tcaagcagga tttacaactg     6240

atgttgtacc ccagggaaat ctacgaacgg cccagacttg atgtgttgac ggcctatcta     6300

gcggcggaat tcaccaaggc ccatgattct gaagcagcaa cggcggcagc agcgattccc     6360

tcccaaagcc tttcggtcaa aacaaaaaaa cagtggcaaa aacctgacca caaaaacccg     6420

aatcccattg cctttatcct ctctagcccc cggtcgggtt cgacgttgct gcgggtgatg     6480

ttagccggac atccggggtt atattcgccg ccagagctgc atttgctccc ctttgagact     6540

atgggcgatc gccaccagga attgggtcta tcccacctcg gcgaagggtt acaacgggcc     6600

ttaatggatc tagaaaacct caccccagag gcaagccagg cgaaggtcaa ccaatgggtc     6660

aaagcgaata cacccattgc agacatctat gcctatctcc aacggcaggc ggaacaacgt     6720

ttactcatcg acaaatctcc cagctacggc agcgatcgcc atattctaga ccacagcgaa     6780

atcctctttg accaggccaa atatatccat ctggtacgcc atccctacgc ggtgattgaa     6840

tcctttaccc gactgcggat ggataaactg ctgggggccg agcagcagaa cccctacgcc     6900

ctcgcggagt ccatttggcg caccagcaac cgcaatattt tagacctggg tcgcacggtt     6960

ggtgcggatc gatatctcca ggtgatttac gaagatctcg tccgtgaccc ccgcaaagtt     7020

ttgacaaata tttgtgattt cctgggggtg gactttgacg aagcgctcct caatccctac     7080

agcggcgatc gccttaccga tggcctccac caacagtcca tgggcgtcgg ggatcccaat     7140

ttcctccagc acaaaaccat tgatccggcc ctcgccgaca aatggcgctc aattaccctg     7200

cccgctgctc tccagctgga tacgatccag ttggccgaaa cgtttgctta cgatctcccc     7260

caggaacccc agctaacacc ccagacccaa tccttgccct cgatggtgga gcggttcgtg     7320

acagtgcgcg gtttagaaac ctgtctctgt gagtggggcg atcgccacca accattggtg     7380

ctacttctcc acggcatcct cgaacagggg gcctcctggc aactcatcgc gccccagttg     7440

gcggcccagg gctattgggt tgtggcccca gacctgcgtg gtcacggcaa atccgcccat     7500

gcccagtcct acagcatgct tgattttttg gctgacgtag atgcccttgc caaacaatta     7560

ggcgatcgcc cctttacctt ggtgggccac tccatgggtt ccatcatcgg tgccatgtat     7620

gcaggaattc gccaaaccca ggtagaaaag ttgatcctcg ttgaaaccat tgtccccaac     7680

gacatcgacg acgctgaaac cggtaatcac ctgacgaccc atctcgatta cctcgccgcg     7740

cccccccaac acccgatctt ccccagccta gaagtggccg cccgtcgcct ccgccaagcc     7800

acgccccaac tacccaaaga cctctcggcg ttcctcaccc agcgcagcac caaatccgtc     7860

gaaaaagggg tgcagtggcg ttgggatgct ttcctccgta cccgggcggg cattgaattc     7920

aatggcatta gcagacgacg ttacctggcc ctgctcaaag atatccaagc gccgatcacc     7980

ctcatctatg gcgatcagag tgaatttaac cgccctgctg atctccaggc gatccaagcg     8040

gctctccccc aggcccaacg tttaacggtt gctggcggcc ataacctcca ttttgagaat     8100

ccccaggcga tcgcccaaat tgtttatcaa caactccaga cccctgtacc caaaacacaa     8160

taa                                                                   8163


<210> 2
<211> 2720
<212> PRT
<213> Synechococcus sp.

<400> 2
Met Val Gly Gln Phe Ala Asn Phe Val Asp Leu Leu Gln Tyr Arg Ala 
1               5                   10                  15      


Lys Leu Gln Ala Arg Lys Thr Val Phe Ser Phe Leu Ala Asp Gly Glu 
            20                  25                  30          


Ala Glu Ser Ala Ala Leu Thr Tyr Gly Glu Leu Asp Gln Lys Ala Gln 
        35                  40                  45              


Ala Ile Ala Ala Phe Leu Gln Ala Asn Gln Ala Gln Gly Gln Arg Ala 
    50                  55                  60                  


Leu Leu Leu Tyr Pro Pro Gly Leu Glu Phe Ile Gly Ala Phe Leu Gly 
65                  70                  75                  80  


Cys Leu Tyr Ala Gly Val Val Ala Val Pro Ala Tyr Pro Pro Arg Pro 
                85                  90                  95      


Asn Lys Ser Phe Asp Arg Leu His Ser Ile Ile Gln Asp Ala Gln Ala 
            100                 105                 110         


Lys Phe Ala Leu Thr Thr Thr Glu Leu Lys Asp Lys Ile Ala Asp Arg 
        115                 120                 125             


Leu Glu Ala Leu Glu Gly Thr Asp Phe His Cys Leu Ala Thr Asp Gln 
    130                 135                 140                 


Val Glu Leu Ile Ser Gly Lys Asn Trp Gln Lys Pro Asn Ile Ser Gly 
145                 150                 155                 160 


Thr Asp Leu Ala Phe Leu Gln Tyr Thr Ser Gly Ser Thr Gly Asp Pro 
                165                 170                 175     


Lys Gly Val Met Val Ser His His Asn Leu Ile His Asn Ser Gly Leu 
            180                 185                 190         


Ile Asn Gln Gly Phe Gln Asp Thr Glu Ala Ser Met Gly Val Ser Trp 
        195                 200                 205             


Leu Pro Pro Tyr His Asp Met Gly Leu Ile Gly Gly Ile Leu Gln Pro 
    210                 215                 220                 


Ile Tyr Val Gly Ala Thr Gln Ile Leu Met Pro Pro Val Ala Phe Leu 
225                 230                 235                 240 


Gln Arg Pro Phe Arg Trp Leu Lys Ala Ile Asn Asp Tyr Arg Val Ser 
                245                 250                 255     


Thr Ser Gly Ala Pro Asn Phe Ala Tyr Asp Leu Cys Ala Ser Gln Ile 
            260                 265                 270         


Thr Pro Glu Gln Ile Arg Glu Leu Asp Leu Ser Cys Trp Arg Leu Ala 
        275                 280                 285             


Phe Ser Gly Ala Glu Pro Ile Arg Ala Val Thr Leu Glu Asn Phe Ala 
    290                 295                 300                 


Lys Thr Phe Ala Thr Ala Gly Phe Gln Lys Ser Ala Phe Tyr Pro Cys 
305                 310                 315                 320 


Tyr Gly Met Ala Glu Thr Thr Leu Ile Val Ser Gly Gly Asn Gly Arg 
                325                 330                 335     


Ala Gln Leu Pro Gln Glu Ile Ile Val Ser Lys Gln Gly Ile Glu Ala 
            340                 345                 350         


Asn Gln Val Arg Pro Ala Gln Gly Thr Glu Thr Thr Val Thr Leu Val 
        355                 360                 365             


Gly Ser Gly Glu Val Ile Gly Asp Gln Ile Val Lys Ile Val Asp Pro 
    370                 375                 380                 


Gln Ala Leu Thr Glu Cys Thr Val Gly Glu Ile Gly Glu Val Trp Val 
385                 390                 395                 400 


Lys Gly Glu Ser Val Ala Gln Gly Tyr Trp Gln Lys Pro Asp Leu Thr 
                405                 410                 415     


Gln Gln Gln Phe Gln Gly Asn Val Gly Ala Glu Thr Gly Phe Leu Arg 
            420                 425                 430         


Thr Gly Asp Leu Gly Phe Leu Gln Gly Gly Glu Leu Tyr Ile Thr Gly 
        435                 440                 445             


Arg Leu Lys Asp Leu Leu Ile Ile Arg Gly Arg Asn His Tyr Pro Gln 
    450                 455                 460                 


Asp Ile Glu Leu Thr Val Glu Val Ala His Pro Ala Leu Arg Gln Gly 
465                 470                 475                 480 


Ala Gly Ala Ala Val Ser Val Asp Val Asn Gly Glu Glu Gln Leu Val 
                485                 490                 495     


Ile Val Gln Glu Val Glu Arg Lys Tyr Ala Arg Lys Leu Asn Val Ala 
            500                 505                 510         


Ala Val Ala Gln Ala Ile Arg Gly Ala Ile Ala Ala Glu His Gln Leu 
        515                 520                 525             


Gln Pro Gln Ala Ile Cys Phe Ile Lys Pro Gly Ser Ile Pro Lys Thr 
    530                 535                 540                 


Ser Ser Gly Lys Ile Arg Arg His Ala Cys Lys Ala Gly Phe Leu Asp 
545                 550                 555                 560 


Gly Ser Leu Ala Val Val Gly Glu Trp Gln Pro Ser His Gln Lys Glu 
                565                 570                 575     


Gly Lys Gly Ile Gly Thr Gln Ala Val Thr Pro Ser Thr Thr Thr Ser 
            580                 585                 590         


Thr Asn Phe Pro Leu Pro Asp Gln His Gln Gln Gln Ile Glu Ala Trp 
        595                 600                 605             


Leu Lys Asp Asn Ile Ala His Arg Leu Gly Ile Thr Pro Gln Gln Leu 
    610                 615                 620                 


Asp Glu Thr Glu Pro Phe Ala Ser Tyr Gly Leu Asp Ser Val Gln Ala 
625                 630                 635                 640 


Val Gln Val Thr Ala Asp Leu Glu Asp Trp Leu Gly Arg Lys Leu Asp 
                645                 650                 655     


Pro Thr Leu Ala Tyr Asp Tyr Pro Thr Ile Arg Thr Leu Ala Gln Phe 
            660                 665                 670         


Leu Val Gln Gly Asn Gln Ala Leu Glu Lys Ile Pro Gln Val Pro Lys 
        675                 680                 685             


Ile Gln Gly Lys Glu Ile Ala Val Val Gly Leu Ser Cys Arg Phe Pro 
    690                 695                 700                 


Gln Ala Asp Asn Pro Glu Ala Phe Trp Glu Leu Leu Arg Asn Gly Lys 
705                 710                 715                 720 


Asp Gly Val Arg Pro Leu Lys Thr Arg Trp Ala Thr Gly Glu Trp Gly 
                725                 730                 735     


Gly Phe Leu Glu Asp Ile Asp Gln Phe Glu Pro Gln Phe Phe Gly Ile 
            740                 745                 750         


Ser Pro Arg Glu Ala Glu Gln Met Asp Pro Gln Gln Arg Leu Leu Leu 
        755                 760                 765             


Glu Val Thr Trp Glu Ala Leu Glu Arg Ala Asn Ile Pro Ala Glu Ser 
    770                 775                 780                 


Leu Arg His Ser Gln Thr Gly Val Phe Val Gly Ile Ser Asn Ser Asp 
785                 790                 795                 800 


Tyr Ala Gln Leu Gln Val Arg Glu Asn Asn Pro Ile Asn Pro Tyr Met 
                805                 810                 815     


Gly Thr Gly Asn Ala His Ser Ile Ala Ala Asn Arg Leu Ser Tyr Phe 
            820                 825                 830         


Leu Asp Leu Arg Gly Val Ser Leu Ser Ile Asp Thr Ala Cys Ser Ser 
        835                 840                 845             


Ser Leu Val Ala Val His Leu Ala Cys Gln Ser Leu Ile Asn Gly Glu 
    850                 855                 860                 


Ser Glu Leu Ala Ile Ala Ala Gly Val Asn Leu Ile Leu Thr Pro Asp 
865                 870                 875                 880 


Val Thr Gln Thr Phe Thr Gln Ala Gly Met Met Ser Lys Thr Gly Arg 
                885                 890                 895     


Cys Gln Thr Phe Asp Ala Glu Ala Asp Gly Tyr Val Arg Gly Glu Gly 
            900                 905                 910         


Cys Gly Val Val Leu Leu Lys Pro Leu Ala Gln Ala Glu Arg Asp Gly 
        915                 920                 925             


Asp Asn Ile Leu Ala Val Ile His Gly Ser Ala Val Asn Gln Asp Gly 
    930                 935                 940                 


Arg Ser Asn Gly Leu Thr Ala Pro Asn Gly Arg Ser Gln Gln Ala Val 
945                 950                 955                 960 


Ile Arg Gln Ala Leu Ala Gln Ala Gly Ile Thr Ala Ala Asp Leu Ala 
                965                 970                 975     


Tyr Leu Glu Ala His Gly Thr Gly Thr Pro Leu Gly Asp Pro Ile Glu 
            980                 985                 990         


Ile Asn Ser Leu Lys Ala Val Leu  Gln Thr Ala Gln Arg  Glu Gln Pro 
        995                 1000                 1005             


Cys Val  Val Gly Ser Val Lys  Thr Asn Ile Gly His  Leu Glu Ala 
    1010                 1015                 1020             


Ala Ala  Gly Ile Ala Gly Leu  Ile Lys Val Ile Leu  Ser Leu Glu 
    1025                 1030                 1035             


His Gly  Met Ile Pro Gln His  Leu His Phe Lys Gln  Leu Asn Pro 
    1040                 1045                 1050             


Arg Ile  Asp Leu Asp Gly Leu  Val Thr Ile Ala Ser  Lys Asp Gln 
    1055                 1060                 1065             


Pro Trp  Ser Gly Gly Ser Gln  Lys Arg Phe Ala Gly  Val Ser Ser 
    1070                 1075                 1080             


Phe Gly  Phe Gly Gly Thr Asn  Ala His Val Ile Val  Gly Asp Tyr 
    1085                 1090                 1095             


Ala Gln  Gln Lys Ser Pro Leu  Ala Pro Pro Ala Thr  Gln Asp Arg 
    1100                 1105                 1110             


Pro Trp  His Leu Leu Thr Leu  Ser Ala Lys Asn Ala  Gln Ala Leu 
    1115                 1120                 1125             


Asn Ala  Leu Gln Lys Ser Tyr  Gly Asp Tyr Leu Ala  Gln His Pro 
    1130                 1135                 1140             


Ser Val  Asp Pro Arg Asp Leu  Cys Leu Ser Ala Asn  Thr Gly Arg 
    1145                 1150                 1155             


Ser Pro  Leu Lys Glu Arg Arg  Phe Phe Val Phe Lys  Gln Val Ala 
    1160                 1165                 1170             


Asp Leu  Gln Gln Thr Leu Asn  Gln Asp Phe Leu Ala  Gln Pro Arg 
    1175                 1180                 1185             


Leu Ser  Ser Pro Ala Lys Ile  Ala Phe Leu Phe Thr  Gly Gln Gly 
    1190                 1195                 1200             


Ser Gln  Tyr Tyr Gly Met Gly  Gln Gln Leu Tyr Gln  Thr Ser Pro 
    1205                 1210                 1215             


Val Phe  Arg Gln Val Leu Asp  Glu Cys Asp Arg Leu  Trp Gln Thr 
    1220                 1225                 1230             


Tyr Ser  Pro Glu Ala Pro Ala  Leu Thr Asp Leu Leu  Tyr Gly Asn 
    1235                 1240                 1245             


His Asn  Pro Asp Leu Val His  Glu Thr Val Tyr Thr  Gln Pro Leu 
    1250                 1255                 1260             


Leu Phe  Ala Val Glu Tyr Ala  Ile Ala Gln Leu Trp  Leu Ser Trp 
    1265                 1270                 1275             


Gly Val  Thr Pro Asp Phe Cys  Met Gly His Ser Val  Gly Glu Tyr 
    1280                 1285                 1290             


Val Ala  Ala Cys Leu Ala Gly  Val Phe Ser Leu Ala  Asp Gly Met 
    1295                 1300                 1305             


Lys Leu  Ile Thr Ala Arg Gly  Lys Leu Met His Ala  Leu Pro Ser 
    1310                 1315                 1320             


Asn Gly  Ser Met Ala Ala Val  Phe Ala Asp Lys Thr  Val Ile Lys 
    1325                 1330                 1335             


Pro Tyr  Leu Ser Glu His Leu  Thr Val Gly Ala Glu  Asn Gly Ser 
    1340                 1345                 1350             


His Leu  Val Leu Ser Gly Lys  Thr Pro Cys Leu Glu  Ala Ser Ile 
    1355                 1360                 1365             


His Lys  Leu Gln Ser Gln Gly  Ile Lys Thr Lys Pro  Leu Lys Val 
    1370                 1375                 1380             


Ser His  Ala Phe His Ser Pro  Leu Met Ala Pro Met  Leu Ala Glu 
    1385                 1390                 1395             


Phe Arg  Glu Ile Ala Glu Gln  Ile Thr Phe His Pro  Pro Arg Ile 
    1400                 1405                 1410             


Pro Leu  Ile Ser Asn Val Thr  Gly Gly Gln Ile Glu  Ala Glu Ile 
    1415                 1420                 1425             


Ala Gln  Ala Asp Tyr Trp Val  Lys His Val Ser Gln  Pro Val Lys 
    1430                 1435                 1440             


Phe Val  Gln Ser Ile Gln Thr  Leu Ala Gln Ala Gly  Val Asn Val 
    1445                 1450                 1455             


Tyr Leu  Glu Ile Gly Val Lys  Pro Val Leu Leu Ser  Met Gly Arg 
    1460                 1465                 1470             


His Cys  Leu Ala Glu Gln Glu  Ala Val Trp Leu Pro  Ser Leu Arg 
    1475                 1480                 1485             


Pro His  Ser Glu Pro Trp Pro  Glu Ile Leu Thr Ser  Leu Gly Lys 
    1490                 1495                 1500             


Leu Tyr  Glu Gln Gly Leu Asn  Ile Asp Trp Gln Thr  Val Glu Ala 
    1505                 1510                 1515             


Gly Asp  Arg Arg Arg Lys Leu  Ile Leu Pro Thr Tyr  Pro Phe Gln 
    1520                 1525                 1530             


Arg Gln  Arg Tyr Trp Phe Asn  Gln Gly Ser Trp Gln  Thr Val Glu 
    1535                 1540                 1545             


Thr Glu  Ser Val Asn Pro Gly  Pro Asp Asp Leu Asn  Asp Trp Leu 
    1550                 1555                 1560             


Tyr Gln  Val Ala Trp Thr Pro  Leu Asp Thr Leu Pro  Pro Ala Pro 
    1565                 1570                 1575             


Glu Pro  Ser Ala Lys Leu Trp  Leu Ile Leu Gly Asp  Arg His Asp 
    1580                 1585                 1590             


His Gln  Pro Ile Glu Ala Gln  Phe Lys Asn Ala Gln  Arg Val Tyr 
    1595                 1600                 1605             


Leu Gly  Gln Ser Asn His Phe  Pro Thr Asn Ala Pro  Trp Glu Val 
    1610                 1615                 1620             


Ser Ala  Asp Ala Leu Asp Asn  Leu Phe Thr His Val  Gly Ser Gln 
    1625                 1630                 1635             


Asn Leu  Ala Gly Ile Leu Tyr  Leu Cys Pro Pro Gly  Glu Asp Pro 
    1640                 1645                 1650             


Glu Asp  Leu Asp Glu Ile Gln  Lys Gln Thr Ser Gly  Phe Ala Leu 
    1655                 1660                 1665             


Gln Leu  Ile Gln Thr Leu Tyr  Gln Gln Lys Ile Ala  Val Pro Cys 
    1670                 1675                 1680             


Trp Phe  Val Thr His Gln Ser  Gln Arg Val Leu Glu  Thr Asp Ala 
    1685                 1690                 1695             


Val Thr  Gly Phe Ala Gln Gly  Gly Leu Trp Gly Leu  Ala Gln Ala 
    1700                 1705                 1710             


Ile Ala  Leu Glu His Pro Glu  Leu Trp Gly Gly Ile  Ile Asp Val 
    1715                 1720                 1725             


Asp Asp  Ser Leu Pro Asn Phe  Ala Gln Ile Cys Gln  Gln Arg Gln 
    1730                 1735                 1740             


Val Gln  Gln Leu Ala Val Arg  His Gln Lys Leu Tyr  Gly Ala Gln 
    1745                 1750                 1755             


Leu Lys  Lys Gln Pro Ser Leu  Pro Gln Lys Asn Leu  Gln Ile Gln 
    1760                 1765                 1770             


Pro Gln  Gln Thr Tyr Leu Val  Thr Gly Gly Leu Gly  Ala Ile Gly 
    1775                 1780                 1785             


Arg Lys  Ile Ala Gln Trp Leu  Ala Ala Ala Gly Ala  Glu Lys Val 
    1790                 1795                 1800             


Ile Leu  Val Ser Arg Arg Ala  Pro Ala Ala Asp Gln  Gln Thr Leu 
    1805                 1810                 1815             


Pro Thr  Asn Ala Val Val Tyr  Pro Cys Asp Leu Ala  Asp Ala Ala 
    1820                 1825                 1830             


Gln Val  Ala Lys Leu Phe Gln  Thr Tyr Pro His Ile  Lys Gly Ile 
    1835                 1840                 1845             


Phe His  Ala Ala Gly Thr Leu  Ala Asp Gly Leu Leu  Gln Gln Gln 
    1850                 1855                 1860             


Thr Trp  Gln Lys Phe Gln Thr  Val Ala Ala Ala Lys  Met Lys Gly 
    1865                 1870                 1875             


Thr Trp  His Leu His Arg His  Ser Gln Lys Leu Asp  Leu Asp Phe 
    1880                 1885                 1890             


Phe Val  Leu Phe Ser Ser Val  Ala Gly Val Leu Gly  Ser Pro Gly 
    1895                 1900                 1905             


Gln Gly  Asn Tyr Ala Ala Ala  Asn Arg Gly Met Ala  Ala Ile Ala 
    1910                 1915                 1920             


Gln Tyr  Arg Gln Ala Gln Gly  Leu Pro Ala Leu Ala  Ile His Trp 
    1925                 1930                 1935             


Gly Pro  Trp Ala Glu Gly Gly  Met Ala Asn Ser Leu  Ser Asn Gln 
    1940                 1945                 1950             


Asn Leu  Ala Trp Leu Pro Pro  Pro Gln Gly Leu Thr  Ile Leu Glu 
    1955                 1960                 1965             


Lys Val  Leu Gly Ala Gln Gly  Glu Met Gly Val Phe  Lys Pro Asp 
    1970                 1975                 1980             


Trp Gln  Asn Leu Ala Lys Gln  Phe Pro Glu Phe Ala  Lys Thr His 
    1985                 1990                 1995             


Tyr Phe  Ala Ala Val Ile Pro  Ser Ala Glu Ala Val  Pro Pro Thr 
    2000                 2005                 2010             


Ala Ser  Ile Phe Asp Lys Leu  Ile Asn Leu Glu Ala  Ser Gln Arg 
    2015                 2020                 2025             


Ala Asp  Tyr Leu Leu Asp Tyr  Leu Arg Arg Ser Val  Ala Gln Ile 
    2030                 2035                 2040             


Leu Lys  Leu Glu Ile Glu Gln  Ile Gln Ser His Asp  Ser Leu Leu 
    2045                 2050                 2055             


Asp Leu  Gly Met Asp Ser Leu  Met Ile Met Glu Ala  Ile Ala Ser 
    2060                 2065                 2070             


Leu Lys  Gln Asp Leu Gln Leu  Met Leu Tyr Pro Arg  Glu Ile Tyr 
    2075                 2080                 2085             


Glu Arg  Pro Arg Leu Asp Val  Leu Thr Ala Tyr Leu  Ala Ala Glu 
    2090                 2095                 2100             


Phe Thr  Lys Ala His Asp Ser  Glu Ala Ala Thr Ala  Ala Ala Ala 
    2105                 2110                 2115             


Ile Pro  Ser Gln Ser Leu Ser  Val Lys Thr Lys Lys  Gln Trp Gln 
    2120                 2125                 2130             


Lys Pro  Asp His Lys Asn Pro  Asn Pro Ile Ala Phe  Ile Leu Ser 
    2135                 2140                 2145             


Ser Pro  Arg Ser Gly Ser Thr  Leu Leu Arg Val Met  Leu Ala Gly 
    2150                 2155                 2160             


His Pro  Gly Leu Tyr Ser Pro  Pro Glu Leu His Leu  Leu Pro Phe 
    2165                 2170                 2175             


Glu Thr  Met Gly Asp Arg His  Gln Glu Leu Gly Leu  Ser His Leu 
    2180                 2185                 2190             


Gly Glu  Gly Leu Gln Arg Ala  Leu Met Asp Leu Glu  Asn Leu Thr 
    2195                 2200                 2205             


Pro Glu  Ala Ser Gln Ala Lys  Val Asn Gln Trp Val  Lys Ala Asn 
    2210                 2215                 2220             


Thr Pro  Ile Ala Asp Ile Tyr  Ala Tyr Leu Gln Arg  Gln Ala Glu 
    2225                 2230                 2235             


Gln Arg  Leu Leu Ile Asp Lys  Ser Pro Ser Tyr Gly  Ser Asp Arg 
    2240                 2245                 2250             


His Ile  Leu Asp His Ser Glu  Ile Leu Phe Asp Gln  Ala Lys Tyr 
    2255                 2260                 2265             


Ile His  Leu Val Arg His Pro  Tyr Ala Val Ile Glu  Ser Phe Thr 
    2270                 2275                 2280             


Arg Leu  Arg Met Asp Lys Leu  Leu Gly Ala Glu Gln  Gln Asn Pro 
    2285                 2290                 2295             


Tyr Ala  Leu Ala Glu Ser Ile  Trp Arg Thr Ser Asn  Arg Asn Ile 
    2300                 2305                 2310             


Leu Asp  Leu Gly Arg Thr Val  Gly Ala Asp Arg Tyr  Leu Gln Val 
    2315                 2320                 2325             


Ile Tyr  Glu Asp Leu Val Arg  Asp Pro Arg Lys Val  Leu Thr Asn 
    2330                 2335                 2340             


Ile Cys  Asp Phe Leu Gly Val  Asp Phe Asp Glu Ala  Leu Leu Asn 
    2345                 2350                 2355             


Pro Tyr  Ser Gly Asp Arg Leu  Thr Asp Gly Leu His  Gln Gln Ser 
    2360                 2365                 2370             


Met Gly  Val Gly Asp Pro Asn  Phe Leu Gln His Lys  Thr Ile Asp 
    2375                 2380                 2385             


Pro Ala  Leu Ala Asp Lys Trp  Arg Ser Ile Thr Leu  Pro Ala Ala 
    2390                 2395                 2400             


Leu Gln  Leu Asp Thr Ile Gln  Leu Ala Glu Thr Phe  Ala Tyr Asp 
    2405                 2410                 2415             


Leu Pro  Gln Glu Pro Gln Leu  Thr Pro Gln Thr Gln  Ser Leu Pro 
    2420                 2425                 2430             


Ser Met  Val Glu Arg Phe Val  Thr Val Arg Gly Leu  Glu Thr Cys 
    2435                 2440                 2445             


Leu Cys  Glu Trp Gly Asp Arg  His Gln Pro Leu Val  Leu Leu Leu 
    2450                 2455                 2460             


His Gly  Ile Leu Glu Gln Gly  Ala Ser Trp Gln Leu  Ile Ala Pro 
    2465                 2470                 2475             


Gln Leu  Ala Ala Gln Gly Tyr  Trp Val Val Ala Pro  Asp Leu Arg 
    2480                 2485                 2490             


Gly His  Gly Lys Ser Ala His  Ala Gln Ser Tyr Ser  Met Leu Asp 
    2495                 2500                 2505             


Phe Leu  Ala Asp Val Asp Ala  Leu Ala Lys Gln Leu  Gly Asp Arg 
    2510                 2515                 2520             


Pro Phe  Thr Leu Val Gly His  Ser Met Gly Ser Ile  Ile Gly Ala 
    2525                 2530                 2535             


Met Tyr  Ala Gly Ile Arg Gln  Thr Gln Val Glu Lys  Leu Ile Leu 
    2540                 2545                 2550             


Val Glu  Thr Ile Val Pro Asn  Asp Ile Asp Asp Ala  Glu Thr Gly 
    2555                 2560                 2565             


Asn His  Leu Thr Thr His Leu  Asp Tyr Leu Ala Ala  Pro Pro Gln 
    2570                 2575                 2580             


His Pro  Ile Phe Pro Ser Leu  Glu Val Ala Ala Arg  Arg Leu Arg 
    2585                 2590                 2595             


Gln Ala  Thr Pro Gln Leu Pro  Lys Asp Leu Ser Ala  Phe Leu Thr 
    2600                 2605                 2610             


Gln Arg  Ser Thr Lys Ser Val  Glu Lys Gly Val Gln  Trp Arg Trp 
    2615                 2620                 2625             


Asp Ala  Phe Leu Arg Thr Arg  Ala Gly Ile Glu Phe  Asn Gly Ile 
    2630                 2635                 2640             


Ser Arg  Arg Arg Tyr Leu Ala  Leu Leu Lys Asp Ile  Gln Ala Pro 
    2645                 2650                 2655             


Ile Thr  Leu Ile Tyr Gly Asp  Gln Ser Glu Phe Asn  Arg Pro Ala 
    2660                 2665                 2670             


Asp Leu  Gln Ala Ile Gln Ala  Ala Leu Pro Gln Ala  Gln Arg Leu 
    2675                 2680                 2685             


Thr Val  Ala Gly Gly His Asn  Leu His Phe Glu Asn  Pro Gln Ala 
    2690                 2695                 2700             


Ile Ala  Gln Ile Val Tyr Gln  Gln Leu Gln Thr Pro  Val Pro Lys 
    2705                 2710                 2715             


Thr Gln  
    2720 


<210> 3
<211> 294
<212> DNA
<213> Synechococcus sp.

<400> 3
attaaccaag gattccagga tacagaggcg agtatgggcg tttcctggtt gccgccctac       60

catgatatgg gcttgatcgg tgggatttta cagcccatct atgtgggagc aacgcaaatt      120

ttaatgcctc ccgtggcctt tttgcagcga ccttttcggt ggctaaaggc gatcaacgat      180

tatcgggttt ccaccagcgg tgcgccgaat tttgcctatg atctctgtgc cagccaaatt      240

accccggaac aaatcagaga actcgatttg agctgttggc gactggcttt ttcc            294


<210> 4
<211> 97
<212> PRT
<213> Synechococcus sp.

<400> 4
Ile Asn Gln Gly Phe Gln Asp Thr Glu Ala Ser Met Gly Val Ser Trp 
1               5                   10                  15      


Leu Pro Pro Tyr His Asp Met Gly Leu Ile Gly Gly Ile Leu Gln Pro 
            20                  25                  30          


Ile Tyr Val Gly Ala Thr Gln Ile Leu Met Pro Pro Val Ala Phe Leu 
        35                  40                  45              


Gln Arg Pro Phe Arg Trp Leu Lys Ala Ile Asn Asp Tyr Arg Val Ser 
    50                  55                  60                  


Thr Ser Gly Ala Pro Asn Phe Ala Tyr Asp Leu Cys Ser Gln Ile Thr 
65                  70                  75                  80  


Pro Glu Gln Ile Arg Glu Leu Asp Leu Ser Cys Trp Arg Leu Ala Phe 
                85                  90                  95      


Ser 
    


<210> 5
<211> 1746
<212> DNA
<213> Legionella pneumophila

<400> 5
gtgaaaaaag aatatttgca gtgccagtct ctggttgacg tcgtcaggtt acgtgcttta       60

cacagcccta acaagaaaag ctgtactttt ctgaacaaag agttggaaga gacgatgact      120

tatgagcaac tggatcaaca cgccaaagca attgcggcaa ctttgcaagc agaaggagca      180

aaacctgggg atagggtctt gttattgttt gcacctggat taccccttat ccaggcattt      240

ttgggctgcc tttatgcagg ctgcattgct gtacccattt acccaccagc ccaagaaaaa      300

ttattggaca aggcacaacg catagttacc aactcaaaac cggtcatagt actgatgatt      360

gcggatcaca tcaaaaaatt caccgcagac gaattaaata caaatcccaa attcctgaaa      420

attcctgcta ttgcgcttga gagcattgag ttaaacagaa gtagtagttg gcaaccaacc      480

tccattaaga gcaatgacat tgcgtttctg caatacactt ccggctcaac catgcaccct      540

aaaggagtga tggtaagcca ccataattta ctggataatc tgaataaaat ttttacctct      600

tttcatatga atgatgaaac cattattttc agctggctgc ccccacatca tgatatgggt      660

ttgattggct gcattctgac ccccatctat ggtggaattc aggcaatcat gatgtcccct      720

ttctcatttt tacaaaaccc gctttcctgg ttaaaacata ttaccaaata caaagcaact      780

atcagtggaa gccctaactt cgcttacgat tattgtgtca aacgaatcag ggaagaaaaa      840

aaagaagggc tggatttaag ttcatgggtg actgctttca acggtgctga gccagtacga      900

gaagaaacca tggaacattt ttatcaggca tttaaagagt ttggatttcg taaagaagcc      960

ttctatccat gctatggcct ggctgaggcc actttgttag tgacgggagg aacaccagga     1020

agttcataca aaacattaac tctggccaaa gaacaatttc aagatcatcg cgtgcatttt     1080

gcagacgata acagtccagg cagttacaag ttagtcagca gtggtaatcc cattcaagaa     1140

gttaaaatta tagatcctga taccttgatc ccatgtgatt ttgaccaggt tggtgaaatt     1200

tgggtacaaa gtaacagtgt cgccaaagga tattggaatc aacccgaaga aacaaggcat     1260

gcgttcgcag gaaaaattaa agacgatgag cgtagcgcaa tctatttaag aaccggggac     1320

ttgggctttc tccatgaaaa tgagttatac gttactggac gcattaaaga cttaattatt     1380

atttatggta aaaatcatta tcctcaggac atagagttca gcctgatgca ttctccgctc     1440

catcacgtat tgggcaaatg cgctgctttt gtgattcagg aggagcatga atataaactg     1500

actgtgatgt gtgaagtaaa aaatcgattc atggatgacg tagctcaaga caatttattc     1560

aatgagattt ttgagcttgt ttacgaaaac caccaattgg aggtacatac tatagtcctg     1620

attcctctta aagcaatgcc acatactacc agcggaaaaa ttcgcaggaa tttttgtcga     1680

aaacatcttt tggataaaac tctgccaata gtggctacct ggcaactcaa taaaattgag     1740

gaataa                                                                1746


<210> 6
<211> 581
<212> PRT
<213> Legionella pneumophila

<400> 6
Met Lys Lys Glu Tyr Leu Gln Cys Gln Ser Leu Val Asp Val Val Arg 
1               5                   10                  15      


Leu Arg Ala Leu His Ser Pro Asn Lys Lys Ser Cys Thr Phe Leu Asn 
            20                  25                  30          


Lys Glu Leu Glu Glu Thr Met Thr Tyr Glu Gln Leu Asp Gln His Ala 
        35                  40                  45              


Lys Ala Ile Ala Ala Thr Leu Gln Ala Glu Gly Ala Lys Pro Gly Asp 
    50                  55                  60                  


Arg Val Leu Leu Leu Phe Ala Pro Gly Leu Pro Leu Ile Gln Ala Phe 
65                  70                  75                  80  


Leu Gly Cys Leu Tyr Ala Gly Cys Ile Ala Val Pro Ile Tyr Pro Pro 
                85                  90                  95      


Ala Gln Glu Lys Leu Leu Asp Lys Ala Gln Arg Ile Val Thr Asn Ser 
            100                 105                 110         


Lys Pro Val Ile Val Leu Met Ile Ala Asp His Ile Lys Lys Phe Thr 
        115                 120                 125             


Ala Asp Glu Leu Asn Thr Asn Pro Lys Phe Leu Lys Ile Pro Ala Ile 
    130                 135                 140                 


Ala Leu Glu Ser Ile Glu Leu Asn Arg Ser Ser Ser Trp Gln Pro Thr 
145                 150                 155                 160 


Ser Ile Lys Ser Asn Asp Ile Ala Phe Leu Gln Tyr Thr Ser Gly Ser 
                165                 170                 175     


Thr Met His Pro Lys Gly Val Met Val Ser His His Asn Leu Leu Asp 
            180                 185                 190         


Asn Leu Asn Lys Ile Phe Thr Ser Phe His Met Asn Asp Glu Thr Ile 
        195                 200                 205             


Ile Phe Ser Trp Leu Pro Pro His His Asp Met Gly Leu Ile Gly Cys 
    210                 215                 220                 


Ile Leu Thr Pro Ile Tyr Gly Gly Ile Gln Ala Ile Met Met Ser Pro 
225                 230                 235                 240 


Phe Ser Phe Leu Gln Asn Pro Leu Ser Trp Leu Lys His Ile Thr Lys 
                245                 250                 255     


Tyr Lys Ala Thr Ile Ser Gly Ser Pro Asn Phe Ala Tyr Asp Tyr Cys 
            260                 265                 270         


Val Lys Arg Ile Arg Glu Glu Lys Lys Glu Gly Leu Asp Leu Ser Ser 
        275                 280                 285             


Trp Val Thr Ala Phe Asn Gly Ala Glu Pro Val Arg Glu Glu Thr Met 
    290                 295                 300                 


Glu His Phe Tyr Gln Ala Phe Lys Glu Phe Gly Phe Arg Lys Glu Ala 
305                 310                 315                 320 


Phe Tyr Pro Cys Tyr Gly Leu Ala Glu Ala Thr Leu Leu Val Thr Gly 
                325                 330                 335     


Gly Thr Pro Gly Ser Ser Tyr Lys Thr Leu Thr Leu Ala Lys Glu Gln 
            340                 345                 350         


Phe Gln Asp His Arg Val His Phe Ala Asp Asp Asn Ser Pro Gly Ser 
        355                 360                 365             


Tyr Lys Leu Val Ser Ser Gly Asn Pro Ile Gln Glu Val Lys Ile Ile 
    370                 375                 380                 


Asp Pro Asp Thr Leu Ile Pro Cys Asp Phe Asp Gln Val Gly Glu Ile 
385                 390                 395                 400 


Trp Val Gln Ser Asn Ser Val Ala Lys Gly Tyr Trp Asn Gln Pro Glu 
                405                 410                 415     


Glu Thr Arg His Ala Phe Ala Gly Lys Ile Lys Asp Asp Glu Arg Ser 
            420                 425                 430         


Ala Ile Tyr Leu Arg Thr Gly Asp Leu Gly Phe Leu His Glu Asn Glu 
        435                 440                 445             


Leu Tyr Val Thr Gly Arg Ile Lys Asp Leu Ile Ile Ile Tyr Gly Lys 
    450                 455                 460                 


Asn His Tyr Pro Gln Asp Ile Glu Phe Ser Leu Met His Ser Pro Leu 
465                 470                 475                 480 


His His Val Leu Gly Lys Cys Ala Ala Phe Val Ile Gln Glu Glu His 
                485                 490                 495     


Glu Tyr Lys Leu Thr Val Met Cys Glu Val Lys Asn Arg Phe Met Asp 
            500                 505                 510         


Asp Val Ala Gln Asp Asn Leu Phe Asn Glu Ile Phe Glu Leu Val Tyr 
        515                 520                 525             


Glu Asn His Gln Leu Glu Val His Thr Ile Val Leu Ile Pro Leu Lys 
    530                 535                 540                 


Ala Met Pro His Thr Thr Ser Gly Lys Ile Arg Arg Asn Phe Cys Arg 
545                 550                 555                 560 


Lys His Leu Leu Asp Lys Thr Leu Pro Ile Val Ala Thr Trp Gln Leu 
                565                 570                 575     


Asn Lys Ile Glu Glu 
            580     


<210> 7
<211> 294
<212> DNA
<213> Legionella pneumophila

<400> 7
atttttacct cttttcatat gaatgatgaa accattattt tcagctggct gcccccacat       60

catgatatgg gtttgattgg ctgcattctg acccccatct atggtggaat tcaggcaatc      120

atgatgtccc ctttctcatt tttacaaaac ccgctttcct ggttaaaaca tattaccaaa      180

tacaaagcaa ctatcagtgg aagccctaac ttcgcttacg attattgtgt caaacgaatc      240

agggaagaaa aaaaagaagg gctggattta agttcatggg tgactgcttt caac            294


<210> 8
<211> 98
<212> PRT
<213> Legionella pneumophila

<400> 8
Ile Phe Thr Ser Phe His Met Asn Asp Glu Thr Ile Ile Phe Ser Trp 
1               5                   10                  15      


Leu Pro Pro His His Asp Met Gly Leu Ile Gly Cys Ile Leu Thr Pro 
            20                  25                  30          


Ile Tyr Gly Gly Ile Gln Ala Ile Met Met Ser Pro Phe Ser Phe Leu 
        35                  40                  45              


Gln Asn Pro Leu Ser Trp Leu Lys His Ile Thr Lys Tyr Lys Ala Thr 
    50                  55                  60                  


Ile Ser Gly Ser Pro Asn Phe Ala Tyr Asp Tyr Cys Val Lys Arg Ile 
65                  70                  75                  80  


Arg Glu Glu Lys Lys Glu Gly Leu Asp Leu Ser Ser Trp Val Thr Ala 
                85                  90                  95      


Phe Asn 
        


<210> 9
<211> 11916
<212> DNA
<213> Bacillus subtilis

<400> 9
atgtatacca gtcaatttca aaccttagtc gatgttattc ggaatagaag caatatatca       60

gatcgcggga tccgttttat cgaatccgat aaaatcgaga catttgtctc ttatcgccaa      120

ttgtttgacg aggcgcaagg ttttcttggc tacttacaac atatcggcat tcagccaaag      180

caagaaattg tgtttcaaat tcaagaaaac aaatcatttg tcgtcgcttt ttgggcgtgt      240

ttattaggag gaatgattcc ggtacccgtc agtatcggag aagataatga ccacaagcta      300

aaggtatggc gcatttggaa tattttaaac aatccattct tgctagcctc tgaaacagta      360

ttagataaaa tgaaaaaatt tgctgctgat cacgatttac aagatttcca tcatcaatta      420

atcgagaaat ccgacatcat tcaggatcga atctacgatc acccggcttc gcaatatgaa      480

cctgaagccg atgaattggc ctttattcaa ttttcttcgg gatcaacagg agacccgaaa      540

ggagtcatgc taacccatca taacttaata cataatacat gtgcaatccg gaatgcgctg      600

gctatcgact taaaagatac tcttttatct tggatgccct taacccatga catggggctc      660

atagcttgcc accttgttcc tgccttagcc ggaatcaatc aaaatttaat gccgacagaa      720

ttatttattc gaagacctat tctctggatg aaaaaagctc atgaacataa agccagcatt      780

ctatcctcac ctaattttgg atacaattac tttcttaaat ttctgaaaga caataaaagt      840

tacgactggg atttatccca tatcagggtc attgcaaacg gagcagaacc tatattgcca      900

gagctatgtg atgaattttt gactagatgc gcagcattca atatgaaacg atctgccatc      960

ttaaatgttt acggtttagc tgaggcttcg gttggcgcaa cattctctaa catcggagaa     1020

agatttgtcc ctgtttattt gcatcgcgat catctaaatc taggtgaaag agccgttgaa     1080

gtaagcaaag aggatcaaaa ttgcgcttca ttcgtcgaag taggaaagcc tattgattac     1140

tgccaaattc gaatctgtaa tgaagcaaac gaaggattgg aagacggatt tatcggtcat     1200

atccagatca agggggagaa tgtgacccaa gggtattata acaaccccga aagtacgaac     1260

agagcgctga ctcccgatgg atgggtgaaa acgggagatc ttggcttcat tagaaaaggg     1320

aatttagtcg taaccggaag ggaaaaagac attatttttg tgaacggaaa aaatgtgtat     1380

cctcacgata ttgaacgagt cgccattgaa ttagaggaca ttgatttagg aagagttgca     1440

gcctgtggtg tatatgatca agagacacga agcagagaaa ttgtactttt tgctgtttac     1500

aaaaaatcag cggagcagtt tgcaccactt gttaaagaca ttaaaaagca tttgtaccag     1560

cgaggcggat ggagcatcaa agaaatcctg ccgatccgaa agctgccaaa aacgacaagc     1620

gggaaagtta aacgctatga gctggctgag cagtatgagt cggggaaatt tgcgctagag     1680

tcaaccaaaa tcaaggaatt tttggagggt cattcgacgg aaccggtaca gactcctatt     1740

catgaaatcg aaacagcatt gctgtctatc ttttcagaag tgatggatgg aaaaaagatt     1800

cacctaaatg atcattattt tgacatgggt gcaacctcat tacagttatc tcaaattgcc     1860

gaacgcattg aacaaaagtt tggttgtgag cttacggttg ctgatctctt tacatatcct     1920

tcaatcgctg atttagcggc attccttgtc gaaaaccatt ccgaaatcaa gcaaactgat     1980

acagcgaagc caagccgctc ttcgtcaaaa gacatcgcta ttatcgggat gtccctcaat     2040

gttccagggg catcgaataa gagtgatttt tggcacctgc tcgaaaacgg tgagcatggc     2100

attcgggaat atcctgcacc aagagttaaa gatgcgatag attatttacg atccattaaa     2160

agcgaacgta acgaaaaaca atttgtgaag ggcggctatt tagatgagat agaccgtttt     2220

gattattcgt tctttggttt agctcccaaa accgcaaaat tcatggatcc caatcaaagg     2280

ctatttttgc aatccgcatg gcatgcgatt gaagatgcag gctatgccgg cgacaccatt     2340

agcgggagtc agctcggggt atatgtaggg tactcgaagg tgggatacga ttacgaacgt     2400

ctcctttctg cgaattatcc ggaggagctt catcattata ttgtgggcaa tcttccctcg     2460

gtgttggcga gtcgaattgc ttactttcta aatttgaaag gaccagcggt taccgtggat     2520

acagcttgct cttcgtcact tgttgctgtt catatggcat gtaaagcttt gcttacaggc     2580

gattgtgaaa tggctcttgc cgggggtatt cgaacttcgc tattaccgat gcgtatcggt     2640

ctcgatatgg aatcttctga cgggctcacg aaaacgttca gcaaggattc ggacggaaca     2700

ggctctggcg aaggcgtggc agcagtcctg ttgaaacctt tgcaggctgc gattcgcgat     2760

ggagatcata tttatggtgt gatcaaggga agcgcgataa accaagacgg gacaaccgtt     2820

ggaatcaccg caccgagccc ggcagctcag accgaggtga ttgagatggc ctggaaagac     2880

gctggcattg ctcctgaaac attgtctttc attgaagcac acggcaccgg aaccaagctc     2940

ggggatcctg ttgaatttaa cggtctttgt aaagcgtttg agaaggttac ggaaaagaaa     3000

cagttttgtg cgatcggctc tgttaaagca aacatcggtc atttgtttga agcggcaggc     3060

atcgttggac tgataaaatc tgcccttatg ttgaatcaca aaaaaatccc gccgctggct     3120

cactttaata aaccgaatcc attaattcca tttcactctt ctccttttta tgtgaaccaa     3180

gaagtgatgg atttcacacc tgaagaccga ccgctgcggg gtggtatcag ttcattcggt     3240

tttagcggaa cgaatgccca tgtagtattg gaagaatata ctcctgaaag tgagtatgca     3300

ccggaggacg ggaatgatcc gcatttattt gtgttatccg cccatactga agcttcacta     3360

tatgaactga ctcatcagta tcggcaatat atttcagatg acagccaatc atcattgagg     3420

tcaatttgct atacggccag tacaggaagg gctcatttag attattgttt agccatgatt     3480

gtatccagca accaagaatt aatagataag ctgaccagtt tgattcaagg cgaaagaaat     3540

cttccccaag tacactttgg ctataaaaac atcaaggaaa tgcagcctgc cgaaaaagac     3600

aatctgagta aacaaatctc tgatctcatg cagcatcggc cctgcacaaa ggatgaacga     3660

atcacatggt tgaatcgtat tgcagaatta tatgtgcaaa gagccgtgat tgactggcga     3720

gcggtttatt ccaatgaagt tgtacaaaaa acgccattgc ctttgtatcc atttgaacgg     3780

aatcgctgtt gggttgaggc tgtctatgaa agcgccaagg aaagaaaaga gaaaggggaa     3840

gtagcattgg atataaatca tacgaagaca catattgagt cctttctgaa gactgtcatc     3900

agcaatgcat cgggaatcag agcggatgag atcgattcga atgcccattt tatcggattc     3960

ggattggatt ccattatgct gacacaggtc aaaaaagcga tcgcagacga atttaatgtg     4020

gatatcccga tggaacgttt ttttgatacg atgaacaaca ttgaaagtgt tgtcgattat     4080

ttggcagaaa atgttccatc agctgcatcc actccgcctc aagaaagtgt tacggcacag     4140

gaagagcttg tgatatcagg agcacagccc gagttggaac atcaagagca tatgttggac     4200

aaaattattg cttctcagaa tcaattaatc cagcaaactt tacaagctca attggatagc     4260

tttaatttgt tgagaaacaa cagccatttt gtatcgaaag aatccgagat ttcgcaagat     4320

aaaacgagcc tttctcctaa atctgtcact gcaaaaaaga attcggctca agaagcaaaa     4380

ccttatattc cttttcagcg tcagaccttg aatgaacagg tcaactatac tccgcagcaa     4440

agacaatatt tagaatcatt tatagagaaa tacgtagaca aaacgaaagg ttccaagcaa     4500

tatacggacg aaacccgatt tgctcatgcc aataaccgca acttgtccag cttccggtct     4560

tattggaaag aaatggttta cccgatcatc gctgaacgct cggacggttc tagaatgtgg     4620

gatattgatg gaaatgaata tatcgatatc accatgggat ttggggttaa tctttttggg     4680

catcacccgt cctttattac tcaaaccgtc gttgattcaa cacattctgc attgccgcct     4740

cttggtccga tgtcaaatgt cgccggagaa gttgcagatc gaattcgtgc atgcacagga     4800

gtagaaaggg tcgcttttta taattcaggc acggaggcag tcatggttgc cctgcgtttg     4860

gcgagggcgg caacaggaag aacgaaagtg gtagtgtttg cgggctctta tcacggcacc     4920

tttgacggcg tattaggtgt tgccaacaca aaaggcgggg ctgagcctgc gaatccgctg     4980

gctccgggca taccgcaaag ctttatgaat gatttgatta ttttgcatta caaccatccg     5040

gattcattgg acgtgattcg caatttggga aatgaattgg cagccgttct ggtggaaccg     5100

gtacaaagcc gcaggccgga tttgcagcca gaatcatttt tgaaagaact gcgggcaatc     5160

acacagcaat ccggaacagc tctgattatg gatgaaatta ttacaggatt tcggatcggt     5220

ctcggcggcg cgcaggaatg gttcgacatc caagcagatt tagtcactta cgggaaaatc     5280

atcggcggcg gccagcctct aggtattgtt gccggaaaag cagagttcat gaatacgatc     5340

gatggcggca catggcagta tggagacgac tcctatccaa cggatgaggc aaaacgcacg     5400

tttgtagcgg gcacctttaa tactcacccg cttacgatga gaatgtcatt agccgtgctt     5460

cgatatcttc aagccgaggg agaaactctg tatgaacggt taaatcaaaa gacaacctac     5520

ttggttgatc aattgaattc ctattttgaa caatcgcaag tgcccattcg tatggtccaa     5580

tttggttcct tattccggtt tgtctcttcg gttgataatg atttgttctt ttaccatctc     5640

aattataaag gagtctatgt ttgggaagga cgcaactgct tcttgtctac ggcccatact     5700

tccgatgata ttgcttatat cattcaagcc gttcaagaaa cggtgaaaga tcttcgccgc     5760

ggcggattta ttccagaagg gccggattct cctaatgacg gaggccataa agaacccgaa     5820

acatacgagc tttctcctga acaaaaacaa ttggctgtag tatcccagta tgggaatgat     5880

gcttctgcgg cattgaatca atctattatg ctaaaagtga aaggggcggt gcagcatacg     5940

ctgttaaaac aagcggtgcg aaatattgta aaacgccatg acgctttacg cacagtcatt     6000

catgtcgatg acgaagtaca gcaagtgcag gctcgaataa atgttgaaat tcctatcatc     6060

gattttaccg gttacccgaa tgaacagcga gagtcggagg ttcaaaaatg gctgacggaa     6120

gatgccaagc gcccgtttca tttccatgaa cagaagccct tgtttagagt tcatgtactt     6180

acgtcgaaac aagacgaaca tctgatcgtt ctgacatttc atcatatcat cgccgatggc     6240

tggtcgatcg ctgtttttgt acaagagcta gagagcacgt acgccgccat tgtacaagga     6300

agcccgcttc catctcatga ggttgtttcg tttcgccaat atttagattg gcagcaagct     6360

cagatagaga atggtcatta tgaagaagga attcgttatt ggcggcagta tctctctgaa     6420

ccaatcccgc aggcaatctt gaccagtatg agttcttccc gttatccgca tggttacgag     6480

ggagatcgct atacagttac actggaccgt ccattgagca aggcgataaa gtcattaagc     6540

attcggatga aaaatagcgt ttttgcaact attctgggag catttcatct ttttctgcag     6600

cagcttacca agcaggctgg ccttgtaatt gggattccaa ccgcaggcca gttgcatatg     6660

aaacaaccta tgctggttgg aaattgtgtc aacatggttc ccgtgaagaa cactgcttct     6720

tcagaaagca cattagccga ttatctgggt catatgaagg aaaacatgga tcaagtcatg     6780

cggcatcaag atgttccgat gacattagtg gccagccagc ttccacacga tcaaatgccg     6840

gatatgcgta ttatttttaa tttggataga ccttttcgaa agctgcattt cggacagatg     6900

gaagctgagc tcattgcgta ccctataaaa tgcatttcat acgatttatt tcttaacgta     6960

acggaatttg atcaagagta tgttcttgat ttcgatttta atacaagcgt catcagttcg     7020

gaaatcatga acaagtgggg aacgggcttt gtaaacttgc tgaaaaaaat ggttgagggg     7080

gactccgcct ctcttgattc cttaaaaatg ttttcgaagg aagatcaaca cgacttgctt     7140

gagctgtatg ctgatcatca gctgcgaatc tcttcaacat tagaccataa gggtgttcgt     7200

gccgtttacg aagagccgga aaatgaaaca gagctgcaaa ttgcgcagat ttgggcggag     7260

cttctcggcc tggagaaagt gggcagatct gaccactttc tgtctctggg tggaaactcg     7320

ctaaaagcga cgcttatgct ttctaagatt cagcaaacat ttaatcaaaa ggtatctata     7380

gggcaattct tcagccatca gactgttaag gagttggcga atttcatccg gggtgaaaag     7440

aatgtcaagt atcccccgat gaagcctgtt gagcagaaag ccttttaccg gacatctcca     7500

gctcagcaaa gagtatattt cctgcatcaa atggaaccga atcaagtttc gcaaaatatg     7560

tttggccaaa tatcgattat agggaagtac gatgaaaaag ccttgattgc atcccttcaa     7620

caggtcatgc agcggcatga agcgtttcgc acttcttttc acatcataga tggtgaaatt     7680

gtgcagcaga ttgctggcga gcttgatttt aacgttcgtg tccattcgat ggaccgtgaa     7740

gaatttgaag cctacgcaga tgggtatgta aaacctttcc gtctggaaca agctcctttg     7800

gttcgtgcgg agctgatcaa ggtcgataac gaacaggctg aattgctcat cgatatgcat     7860

catatcattt ccgacggcta ttccatgagc atacttacaa atgaattgtt cgctttgtat     7920

catggtaacc cattaccgga aattccattt gaatataaag acttcgcaga gtggcaaaac     7980

cagctgttaa tcggagaggt catggagcag caggaagaat actggctcga gcaattcaag     8040

caagaagttc ctatccttca attgccggca gacggttcaa gagcgatgga atggtcttcc     8100

gaagggcagc gtgtgacctg ttccttgcag tcgagtttaa tccgttcgct tcaagaaatg     8160

gcgcaacaga agggaacgac tctgtatatg gtgcttctgg ctgcttacaa cgtgctgctt     8220

cacaaatata cgggccaaga agatatcgtc gtaggcacgc cagtttccgg aagaaatcaa     8280

ccgaatattg aaagcatgat tggtatattc attcaaacca tggggattcg cacgaaacca     8340

caggctaata aaaggtttac ggattatttg gacgaagtta aacggcaaac gcttgatgcg     8400

ttcgaaaacc aggattatcc gtttgactgg ctagtagaaa aagtaaacgt acaacgggaa     8460

acaacaggta agtcactatt taacacaatg tttgtgtatc aaaatattga atttcaagag     8520

atccatcaag atgggtgtac gtttagggta aaagaacgta atcccggagt ctctttatat     8580

gatttgatgt taacgatcga ggatgcagaa aaacagttag atattcattt cgattttaat     8640

ccaaaccagt ttgaacaaga aacgattgaa caaatcataa ggcactacac cagcctttta     8700

gacagtcttg ttaaggagcc ggagaaatcc ttgtcttccg ttcctatgct gtctgacatc     8760

gagaggcacc agcttctgat ggggtgtaat gacacggaga cgccgtttcc gcacaatgac     8820

acagtatgtc aatggtttga aacgcaagca gaacagcggc ctgatgatga agccgttata     8880

tttggcaatg aacggtgcac gtacgggcag ctaaatgagc gggtaaatca attggcgcgc     8940

acgttaagaa cgaagggcgt tcaagcggat cagtttgttg ccatcatctg cccgcatcgc     9000

atcgagctga ttgttggaat tttggctgtt ctaaaagccg gcggcgcata cgtgccaatt     9060

gatccggagt atccagagga ccggatacaa tatatgctga aggattcaga ggctaagatc     9120

gttttggcac agctcgattt gcataaacac ttaacgtttg atgctgacgt tgtgcttttg     9180

gatgaggaaa gctcatatca tgaggatcgt tcgaatcttg aaccgacctg cggtgcaaat     9240

gatttggcat acatgatcta tacgtcgggc tccacaggga acccgaaagg tgtactcatt     9300

gagcaccggg gattagctaa ttatattgag tgggcgaaag aggtttatgt gaatgatgag     9360

aaaaccaact tccctttata ctcgtccatc tcttttgatc taacggtgac gtcgattttt     9420

acaccgctgg ttacaggaaa taccatcatt gtctttgatg gtgaagacaa aagtgcggtg     9480

ctttcaacaa ttatgcagga tccgagaata gatatcatca aattgacgcc ggcgcatttg     9540

catgtgctca aagaaatgaa gatagcagat ggaacgacaa ttcgaaaaat gattgtcggc     9600

ggggaaaatt taagcacccg gcttgcccaa agtgtcagtg agcagtttaa aggccaactg     9660

gacatattca atgaatacgg accgacagaa gcggtcgtcg gatgtatgat ttatcggtac     9720

gacactaaac gtgacaggcg agaatttgtg ccaataggct cccctgccgc caatacgagc     9780

atttatgtgt tggatgccag catgaacttg gttccggtcg gcgtaccggg tgaaatgtat     9840

atcggtggag ccggtgtagc cagaggatac tggaatcgcc cggatttaac agcagagaag     9900

ttcgttcaca acccgtttgc tccgggaacg ataatgtaca aaacgggtga cttggcaaaa     9960

cgattacgtg atggaaatct catatattta ggccgaatcg atgaacaagt caaaatccga    10020

ggacatcgaa ttgaacttgg tgaagttgaa gctgcaatgc ataaagtgga agcggtccaa    10080

aaggccgtag ttttagccag agaagaagag gatggcttac aacaactgtg tgcgtattat    10140

gtgagcaata aacctataac aattgcggag attagagaac aattatcact ggagctgccg    10200

gactacatgg ttccgtccca ttatatccaa cttgagcaat taccgttaac gtccaacggg    10260

aaaataaatc gtaaagcact gcctgcacca gaggtaagtt tagagcaaat agctgaatat    10320

gtaccgccag gcaatgaggt tgaatctaag cttgcagtct tatggcaaga gatgctcgga    10380

atacatcgtg tggggatcaa gcacaatttc ttcgatcttg gaggaaattc catacgcgcg    10440

acggccttag ccgccagaat ccacaaagaa ctggatgtca atctgtctgt aaaagacata    10500

tttaagtttc ctactattga acagttggct aacatggcgt tacgcatgga gaaaattcga    10560

tatgtatcaa ttccgtctgc acagaaaatc tcctattatc cagtttcttc ggcacagaaa    10620

cggatgtatt tgttaagtca tacagaagga ggcgagctga cgtacaatat gacgggcgcc    10680

atgagtgtag aaggggctat tgatctagaa cgattgaccg ctgcttttca aaaattaatt    10740

gaacgtcatg aagttttgcg gaccagcttt gaactatacg aaggcgagcc ggcacagcga    10800

attcatccaa gcattgaatt tacaatagaa cagattcaag cgagagaaga ggaagtggaa    10860

gaccatgtac ttgattttat caaatcgttt gatttagcca agccgccgtt aatgcgagtg    10920

ggactgattg aacttacacc cgaaaagcat gtactgctag tcgatatgca tcatatcatt    10980

tccgatggcg tgtctatgaa cattctaatg aaagatttaa atcaatttta taaagggatc    11040

gaaccggatc cgcttcccat tcaatataag gactatgcgg tttggcagca aacggaagct    11100

cagaggcaaa acatcaaaaa acaggaagcg tattggctta atcgttttca tgatgagatt    11160

cctgtattgg atatgccaac ggattacgag agacctgcta tacgcgatta cgaaggcgaa    11220

tcatttgaat ttcttatacc gatagaatta aaacagcgct taagtcaaat ggaagaagct    11280

acaggaacaa cattgtatat gattttaatg gcagcttata caattctttt atccaaatac    11340

agcggacagg aagatatcgt cgtagggacc ccggtctccg gccgaagtca tatggatgta    11400

gagtctgttg tgggaatgtt tgtaaacacc ttagtcattc gcaatcaccc ggcaggccgt    11460

aaaatattcg aggattactt aaacgaagtg aaggaaaaca tgctaaatgc ctatcaaaat    11520

caagactatc cattggaaga attgatccaa catgtacatc ttctaaaaga ttcaagccgc    11580

aaccctttat tcgatacgat gtttgtgctg caaaatctcg atcaggttga attgaacctt    11640

gattcccttc gattcacgcc ttataagctt catcatacag ttgccaaatt cgatttgacc    11700

ttgtcgattc agacagatca agacaaacat cacggtctgt tcgaatattc gaagaaacta    11760

tttaagaaaa gcagaatcga agctttgtca aaagactatt tacacatctt atccgttatc    11820

agtcaacagc caagtataca aatcgaacat atcgaattaa gcggcagcac cgcggaagat    11880

gataacttga tccattctat tgaactgaac ttttaa                              11916


<210> 10
<211> 3971
<212> PRT
<213> Bacillus subtilis

<400> 10
Met Tyr Thr Ser Gln Phe Gln Thr Leu Val Asp Val Ile Arg Asn Arg 
1               5                   10                  15      


Ser Asn Ile Ser Asp Arg Gly Ile Arg Phe Ile Glu Ser Asp Lys Ile 
            20                  25                  30          


Glu Thr Phe Val Ser Tyr Arg Gln Leu Phe Asp Glu Ala Gln Gly Phe 
        35                  40                  45              


Leu Gly Tyr Leu Gln His Ile Gly Ile Gln Pro Lys Gln Glu Ile Val 
    50                  55                  60                  


Phe Gln Ile Gln Glu Asn Lys Ser Phe Val Val Ala Phe Trp Ala Cys 
65                  70                  75                  80  


Leu Leu Gly Gly Met Ile Pro Val Pro Val Ser Ile Gly Glu Asp Asn 
                85                  90                  95      


Asp His Lys Leu Lys Val Trp Arg Ile Trp Asn Ile Leu Asn Asn Pro 
            100                 105                 110         


Phe Leu Leu Ala Ser Glu Thr Val Leu Asp Lys Met Lys Lys Phe Ala 
        115                 120                 125             


Ala Asp His Asp Leu Gln Asp Phe His His Gln Leu Ile Glu Lys Ser 
    130                 135                 140                 


Asp Ile Ile Gln Asp Arg Ile Tyr Asp His Pro Ala Ser Gln Tyr Glu 
145                 150                 155                 160 


Pro Glu Ala Asp Glu Leu Ala Phe Ile Gln Phe Ser Ser Gly Ser Thr 
                165                 170                 175     


Gly Asp Pro Lys Gly Val Met Leu Thr His His Asn Leu Ile His Asn 
            180                 185                 190         


Thr Cys Ala Ile Arg Asn Ala Leu Ala Ile Asp Leu Lys Asp Thr Leu 
        195                 200                 205             


Leu Ser Trp Met Pro Leu Thr His Asp Met Gly Leu Ile Ala Cys His 
    210                 215                 220                 


Leu Val Pro Ala Leu Ala Gly Ile Asn Gln Asn Leu Met Pro Thr Glu 
225                 230                 235                 240 


Leu Phe Ile Arg Arg Pro Ile Leu Trp Met Lys Lys Ala His Glu His 
                245                 250                 255     


Lys Ala Ser Ile Leu Ser Ser Pro Asn Phe Gly Tyr Asn Tyr Phe Leu 
            260                 265                 270         


Lys Phe Leu Lys Asp Asn Lys Ser Tyr Asp Trp Asp Leu Ser His Ile 
        275                 280                 285             


Arg Val Ile Ala Asn Gly Ala Glu Pro Ile Leu Pro Glu Leu Cys Asp 
    290                 295                 300                 


Glu Phe Leu Thr Arg Cys Ala Ala Phe Asn Met Lys Arg Ser Ala Ile 
305                 310                 315                 320 


Leu Asn Val Tyr Gly Leu Ala Glu Ala Ser Val Gly Ala Thr Phe Ser 
                325                 330                 335     


Asn Ile Gly Glu Arg Phe Val Pro Val Tyr Leu His Arg Asp His Leu 
            340                 345                 350         


Asn Leu Gly Glu Arg Ala Val Glu Val Ser Lys Glu Asp Gln Asn Cys 
        355                 360                 365             


Ala Ser Phe Val Glu Val Gly Lys Pro Ile Asp Tyr Cys Gln Ile Arg 
    370                 375                 380                 


Ile Cys Asn Glu Ala Asn Glu Gly Leu Glu Asp Gly Phe Ile Gly His 
385                 390                 395                 400 


Ile Gln Ile Lys Gly Glu Asn Val Thr Gln Gly Tyr Tyr Asn Asn Pro 
                405                 410                 415     


Glu Ser Thr Asn Arg Ala Leu Thr Pro Asp Gly Trp Val Lys Thr Gly 
            420                 425                 430         


Asp Leu Gly Phe Ile Arg Lys Gly Asn Leu Val Val Thr Gly Arg Glu 
        435                 440                 445             


Lys Asp Ile Ile Phe Val Asn Gly Lys Asn Val Tyr Pro His Asp Ile 
    450                 455                 460                 


Glu Arg Val Ala Ile Glu Leu Glu Asp Ile Asp Leu Gly Arg Val Ala 
465                 470                 475                 480 


Ala Cys Gly Val Tyr Asp Gln Glu Thr Arg Ser Arg Glu Ile Val Leu 
                485                 490                 495     


Phe Ala Val Tyr Lys Lys Ser Ala Glu Gln Phe Ala Pro Leu Val Lys 
            500                 505                 510         


Asp Ile Lys Lys His Leu Tyr Gln Arg Gly Gly Trp Ser Ile Lys Glu 
        515                 520                 525             


Ile Leu Pro Ile Arg Lys Leu Pro Lys Thr Thr Ser Gly Lys Val Lys 
    530                 535                 540                 


Arg Tyr Glu Leu Ala Glu Gln Tyr Glu Ser Gly Lys Phe Ala Leu Glu 
545                 550                 555                 560 


Ser Thr Lys Ile Lys Glu Phe Leu Glu Gly His Ser Thr Glu Pro Val 
                565                 570                 575     


Gln Thr Pro Ile His Glu Ile Glu Thr Ala Leu Leu Ser Ile Phe Ser 
            580                 585                 590         


Glu Val Met Asp Gly Lys Lys Ile His Leu Asn Asp His Tyr Phe Asp 
        595                 600                 605             


Met Gly Ala Thr Ser Leu Gln Leu Ser Gln Ile Ala Glu Arg Ile Glu 
    610                 615                 620                 


Gln Lys Phe Gly Cys Glu Leu Thr Val Ala Asp Leu Phe Thr Tyr Pro 
625                 630                 635                 640 


Ser Ile Ala Asp Leu Ala Ala Phe Leu Val Glu Asn His Ser Glu Ile 
                645                 650                 655     


Lys Gln Thr Asp Thr Ala Lys Pro Ser Arg Ser Ser Ser Lys Asp Ile 
            660                 665                 670         


Ala Ile Ile Gly Met Ser Leu Asn Val Pro Gly Ala Ser Asn Lys Ser 
        675                 680                 685             


Asp Phe Trp His Leu Leu Glu Asn Gly Glu His Gly Ile Arg Glu Tyr 
    690                 695                 700                 


Pro Ala Pro Arg Val Lys Asp Ala Ile Asp Tyr Leu Arg Ser Ile Lys 
705                 710                 715                 720 


Ser Glu Arg Asn Glu Lys Gln Phe Val Lys Gly Gly Tyr Leu Asp Glu 
                725                 730                 735     


Ile Asp Arg Phe Asp Tyr Ser Phe Phe Gly Leu Ala Pro Lys Thr Ala 
            740                 745                 750         


Lys Phe Met Asp Pro Asn Gln Arg Leu Phe Leu Gln Ser Ala Trp His 
        755                 760                 765             


Ala Ile Glu Asp Ala Gly Tyr Ala Gly Asp Thr Ile Ser Gly Ser Gln 
    770                 775                 780                 


Leu Gly Val Tyr Val Gly Tyr Ser Lys Val Gly Tyr Asp Tyr Glu Arg 
785                 790                 795                 800 


Leu Leu Ser Ala Asn Tyr Pro Glu Glu Leu His His Tyr Ile Val Gly 
                805                 810                 815     


Asn Leu Pro Ser Val Leu Ala Ser Arg Ile Ala Tyr Phe Leu Asn Leu 
            820                 825                 830         


Lys Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val 
        835                 840                 845             


Ala Val His Met Ala Cys Lys Ala Leu Leu Thr Gly Asp Cys Glu Met 
    850                 855                 860                 


Ala Leu Ala Gly Gly Ile Arg Thr Ser Leu Leu Pro Met Arg Ile Gly 
865                 870                 875                 880 


Leu Asp Met Glu Ser Ser Asp Gly Leu Thr Lys Thr Phe Ser Lys Asp 
                885                 890                 895     


Ser Asp Gly Thr Gly Ser Gly Glu Gly Val Ala Ala Val Leu Leu Lys 
            900                 905                 910         


Pro Leu Gln Ala Ala Ile Arg Asp Gly Asp His Ile Tyr Gly Val Ile 
        915                 920                 925             


Lys Gly Ser Ala Ile Asn Gln Asp Gly Thr Thr Val Gly Ile Thr Ala 
    930                 935                 940                 


Pro Ser Pro Ala Ala Gln Thr Glu Val Ile Glu Met Ala Trp Lys Asp 
945                 950                 955                 960 


Ala Gly Ile Ala Pro Glu Thr Leu Ser Phe Ile Glu Ala His Gly Thr 
                965                 970                 975     


Gly Thr Lys Leu Gly Asp Pro Val Glu Phe Asn Gly Leu Cys Lys Ala 
            980                 985                 990         


Phe Glu Lys Val Thr Glu Lys Lys  Gln Phe Cys Ala Ile  Gly Ser Val 
        995                 1000                 1005             


Lys Ala  Asn Ile Gly His Leu  Phe Glu Ala Ala Gly  Ile Val Gly 
    1010                 1015                 1020             


Leu Ile  Lys Ser Ala Leu Met  Leu Asn His Lys Lys  Ile Pro Pro 
    1025                 1030                 1035             


Leu Ala  His Phe Asn Lys Pro  Asn Pro Leu Ile Pro  Phe His Ser 
    1040                 1045                 1050             


Ser Pro  Phe Tyr Val Asn Gln  Glu Val Met Asp Phe  Thr Pro Glu 
    1055                 1060                 1065             


Asp Arg  Pro Leu Arg Gly Gly  Ile Ser Ser Phe Gly  Phe Ser Gly 
    1070                 1075                 1080             


Thr Asn  Ala His Val Val Leu  Glu Glu Tyr Thr Pro  Glu Ser Glu 
    1085                 1090                 1095             


Tyr Ala  Pro Glu Asp Gly Asn  Asp Pro His Leu Phe  Val Leu Ser 
    1100                 1105                 1110             


Ala His  Thr Glu Ala Ser Leu  Tyr Glu Leu Thr His  Gln Tyr Arg 
    1115                 1120                 1125             


Gln Tyr  Ile Ser Asp Asp Ser  Gln Ser Ser Leu Arg  Ser Ile Cys 
    1130                 1135                 1140             


Tyr Thr  Ala Ser Thr Gly Arg  Ala His Leu Asp Tyr  Cys Leu Ala 
    1145                 1150                 1155             


Met Ile  Val Ser Ser Asn Gln  Glu Leu Ile Asp Lys  Leu Thr Ser 
    1160                 1165                 1170             


Leu Ile  Gln Gly Glu Arg Asn  Leu Pro Gln Val His  Phe Gly Tyr 
    1175                 1180                 1185             


Lys Asn  Ile Lys Glu Met Gln  Pro Ala Glu Lys Asp  Asn Leu Ser 
    1190                 1195                 1200             


Lys Gln  Ile Ser Asp Leu Met  Gln His Arg Pro Cys  Thr Lys Asp 
    1205                 1210                 1215             


Glu Arg  Ile Thr Trp Leu Asn  Arg Ile Ala Glu Leu  Tyr Val Gln 
    1220                 1225                 1230             


Arg Ala  Val Ile Asp Trp Arg  Ala Val Tyr Ser Asn  Glu Val Val 
    1235                 1240                 1245             


Gln Lys  Thr Pro Leu Pro Leu  Tyr Pro Phe Glu Arg  Asn Arg Cys 
    1250                 1255                 1260             


Trp Val  Glu Ala Val Tyr Glu  Ser Ala Lys Glu Arg  Lys Glu Lys 
    1265                 1270                 1275             


Gly Glu  Val Ala Leu Asp Ile  Asn His Thr Lys Thr  His Ile Glu 
    1280                 1285                 1290             


Ser Phe  Leu Lys Thr Val Ile  Ser Asn Ala Ser Gly  Ile Arg Ala 
    1295                 1300                 1305             


Asp Glu  Ile Asp Ser Asn Ala  His Phe Ile Gly Phe  Gly Leu Asp 
    1310                 1315                 1320             


Ser Ile  Met Leu Thr Gln Val  Lys Lys Ala Ile Ala  Asp Glu Phe 
    1325                 1330                 1335             


Asn Val  Asp Ile Pro Met Glu  Arg Phe Phe Asp Thr  Met Asn Asn 
    1340                 1345                 1350             


Ile Glu  Ser Val Val Asp Tyr  Leu Ala Glu Asn Val  Pro Ser Ala 
    1355                 1360                 1365             


Ala Ser  Thr Pro Pro Gln Glu  Ser Val Thr Ala Gln  Glu Glu Leu 
    1370                 1375                 1380             


Val Ile  Ser Gly Ala Gln Pro  Glu Leu Glu His Gln  Glu His Met 
    1385                 1390                 1395             


Leu Asp  Lys Ile Ile Ala Ser  Gln Asn Gln Leu Ile  Gln Gln Thr 
    1400                 1405                 1410             


Leu Gln  Ala Gln Leu Asp Ser  Phe Asn Leu Leu Arg  Asn Asn Ser 
    1415                 1420                 1425             


His Phe  Val Ser Lys Glu Ser  Glu Ile Ser Gln Asp  Lys Thr Ser 
    1430                 1435                 1440             


Leu Ser  Pro Lys Ser Val Thr  Ala Lys Lys Asn Ser  Ala Gln Glu 
    1445                 1450                 1455             


Ala Lys  Pro Tyr Ile Pro Phe  Gln Arg Gln Thr Leu  Asn Glu Gln 
    1460                 1465                 1470             


Val Asn  Tyr Thr Pro Gln Gln  Arg Gln Tyr Leu Glu  Ser Phe Ile 
    1475                 1480                 1485             


Glu Lys  Tyr Val Asp Lys Thr  Lys Gly Ser Lys Gln  Tyr Thr Asp 
    1490                 1495                 1500             


Glu Thr  Arg Phe Ala His Ala  Asn Asn Arg Asn Leu  Ser Ser Phe 
    1505                 1510                 1515             


Arg Ser  Tyr Trp Lys Glu Met  Val Tyr Pro Ile Ile  Ala Glu Arg 
    1520                 1525                 1530             


Ser Asp  Gly Ser Arg Met Trp  Asp Ile Asp Gly Asn  Glu Tyr Ile 
    1535                 1540                 1545             


Asp Ile  Thr Met Gly Phe Gly  Val Asn Leu Phe Gly  His His Pro 
    1550                 1555                 1560             


Ser Phe  Ile Thr Gln Thr Val  Val Asp Ser Thr His  Ser Ala Leu 
    1565                 1570                 1575             


Pro Pro  Leu Gly Pro Met Ser  Asn Val Ala Gly Glu  Val Ala Asp 
    1580                 1585                 1590             


Arg Ile  Arg Ala Cys Thr Gly  Val Glu Arg Val Ala  Phe Tyr Asn 
    1595                 1600                 1605             


Ser Gly  Thr Glu Ala Val Met  Val Ala Leu Arg Leu  Ala Arg Ala 
    1610                 1615                 1620             


Ala Thr  Gly Arg Thr Lys Val  Val Val Phe Ala Gly  Ser Tyr His 
    1625                 1630                 1635             


Gly Thr  Phe Asp Gly Val Leu  Gly Val Ala Asn Thr  Lys Gly Gly 
    1640                 1645                 1650             


Ala Glu  Pro Ala Asn Pro Leu  Ala Pro Gly Ile Pro  Gln Ser Phe 
    1655                 1660                 1665             


Met Asn  Asp Leu Ile Ile Leu  His Tyr Asn His Pro  Asp Ser Leu 
    1670                 1675                 1680             


Asp Val  Ile Arg Asn Leu Gly  Asn Glu Leu Ala Ala  Val Leu Val 
    1685                 1690                 1695             


Glu Pro  Val Gln Ser Arg Arg  Pro Asp Leu Gln Pro  Glu Ser Phe 
    1700                 1705                 1710             


Leu Lys  Glu Leu Arg Ala Ile  Thr Gln Gln Ser Gly  Thr Ala Leu 
    1715                 1720                 1725             


Ile Met  Asp Glu Ile Ile Thr  Gly Phe Arg Ile Gly  Leu Gly Gly 
    1730                 1735                 1740             


Ala Gln  Glu Trp Phe Asp Ile  Gln Ala Asp Leu Val  Thr Tyr Gly 
    1745                 1750                 1755             


Lys Ile  Ile Gly Gly Gly Gln  Pro Leu Gly Ile Val  Ala Gly Lys 
    1760                 1765                 1770             


Ala Glu  Phe Met Asn Thr Ile  Asp Gly Gly Thr Trp  Gln Tyr Gly 
    1775                 1780                 1785             


Asp Asp  Ser Tyr Pro Thr Asp  Glu Ala Lys Arg Thr  Phe Val Ala 
    1790                 1795                 1800             


Gly Thr  Phe Asn Thr His Pro  Leu Thr Met Arg Met  Ser Leu Ala 
    1805                 1810                 1815             


Val Leu  Arg Tyr Leu Gln Ala  Glu Gly Glu Thr Leu  Tyr Glu Arg 
    1820                 1825                 1830             


Leu Asn  Gln Lys Thr Thr Tyr  Leu Val Asp Gln Leu  Asn Ser Tyr 
    1835                 1840                 1845             


Phe Glu  Gln Ser Gln Val Pro  Ile Arg Met Val Gln  Phe Gly Ser 
    1850                 1855                 1860             


Leu Phe  Arg Phe Val Ser Ser  Val Asp Asn Asp Leu  Phe Phe Tyr 
    1865                 1870                 1875             


His Leu  Asn Tyr Lys Gly Val  Tyr Val Trp Glu Gly  Arg Asn Cys 
    1880                 1885                 1890             


Phe Leu  Ser Thr Ala His Thr  Ser Asp Asp Ile Ala  Tyr Ile Ile 
    1895                 1900                 1905             


Gln Ala  Val Gln Glu Thr Val  Lys Asp Leu Arg Arg  Gly Gly Phe 
    1910                 1915                 1920             


Ile Pro  Glu Gly Pro Asp Ser  Pro Asn Asp Gly Gly  His Lys Glu 
    1925                 1930                 1935             


Pro Glu  Thr Tyr Glu Leu Ser  Pro Glu Gln Lys Gln  Leu Ala Val 
    1940                 1945                 1950             


Val Ser  Gln Tyr Gly Asn Asp  Ala Ser Ala Ala Leu  Asn Gln Ser 
    1955                 1960                 1965             


Ile Met  Leu Lys Val Lys Gly  Ala Val Gln His Thr  Leu Leu Lys 
    1970                 1975                 1980             


Gln Ala  Val Arg Asn Ile Val  Lys Arg His Asp Ala  Leu Arg Thr 
    1985                 1990                 1995             


Val Ile  His Val Asp Asp Glu  Val Gln Gln Val Gln  Ala Arg Ile 
    2000                 2005                 2010             


Asn Val  Glu Ile Pro Ile Ile  Asp Phe Thr Gly Tyr  Pro Asn Glu 
    2015                 2020                 2025             


Gln Arg  Glu Ser Glu Val Gln  Lys Trp Leu Thr Glu  Asp Ala Lys 
    2030                 2035                 2040             


Arg Pro  Phe His Phe His Glu  Gln Lys Pro Leu Phe  Arg Val His 
    2045                 2050                 2055             


Val Leu  Thr Ser Lys Gln Asp  Glu His Leu Ile Val  Leu Thr Phe 
    2060                 2065                 2070             


His His  Ile Ile Ala Asp Gly  Trp Ser Ile Ala Val  Phe Val Gln 
    2075                 2080                 2085             


Glu Leu  Glu Ser Thr Tyr Ala  Ala Ile Val Gln Gly  Ser Pro Leu 
    2090                 2095                 2100             


Pro Ser  His Glu Val Val Ser  Phe Arg Gln Tyr Leu  Asp Trp Gln 
    2105                 2110                 2115             


Gln Ala  Gln Ile Glu Asn Gly  His Tyr Glu Glu Gly  Ile Arg Tyr 
    2120                 2125                 2130             


Trp Arg  Gln Tyr Leu Ser Glu  Pro Ile Pro Gln Ala  Ile Leu Thr 
    2135                 2140                 2145             


Ser Met  Ser Ser Ser Arg Tyr  Pro His Gly Tyr Glu  Gly Asp Arg 
    2150                 2155                 2160             


Tyr Thr  Val Thr Leu Asp Arg  Pro Leu Ser Lys Ala  Ile Lys Ser 
    2165                 2170                 2175             


Leu Ser  Ile Arg Met Lys Asn  Ser Val Phe Ala Thr  Ile Leu Gly 
    2180                 2185                 2190             


Ala Phe  His Leu Phe Leu Gln  Gln Leu Thr Lys Gln  Ala Gly Leu 
    2195                 2200                 2205             


Val Ile  Gly Ile Pro Thr Ala  Gly Gln Leu His Met  Lys Gln Pro 
    2210                 2215                 2220             


Met Leu  Val Gly Asn Cys Val  Asn Met Val Pro Val  Lys Asn Thr 
    2225                 2230                 2235             


Ala Ser  Ser Glu Ser Thr Leu  Ala Asp Tyr Leu Gly  His Met Lys 
    2240                 2245                 2250             


Glu Asn  Met Asp Gln Val Met  Arg His Gln Asp Val  Pro Met Thr 
    2255                 2260                 2265             


Leu Val  Ala Ser Gln Leu Pro  His Asp Gln Met Pro  Asp Met Arg 
    2270                 2275                 2280             


Ile Ile  Phe Asn Leu Asp Arg  Pro Phe Arg Lys Leu  His Phe Gly 
    2285                 2290                 2295             


Gln Met  Glu Ala Glu Leu Ile  Ala Tyr Pro Ile Lys  Cys Ile Ser 
    2300                 2305                 2310             


Tyr Asp  Leu Phe Leu Asn Val  Thr Glu Phe Asp Gln  Glu Tyr Val 
    2315                 2320                 2325             


Leu Asp  Phe Asp Phe Asn Thr  Ser Val Ile Ser Ser  Glu Ile Met 
    2330                 2335                 2340             


Asn Lys  Trp Gly Thr Gly Phe  Val Asn Leu Leu Lys  Lys Met Val 
    2345                 2350                 2355             


Glu Gly  Asp Ser Ala Ser Leu  Asp Ser Leu Lys Met  Phe Ser Lys 
    2360                 2365                 2370             


Glu Asp  Gln His Asp Leu Leu  Glu Leu Tyr Ala Asp  His Gln Leu 
    2375                 2380                 2385             


Arg Ile  Ser Ser Thr Leu Asp  His Lys Gly Val Arg  Ala Val Tyr 
    2390                 2395                 2400             


Glu Glu  Pro Glu Asn Glu Thr  Glu Leu Gln Ile Ala  Gln Ile Trp 
    2405                 2410                 2415             


Ala Glu  Leu Leu Gly Leu Glu  Lys Val Gly Arg Ser  Asp His Phe 
    2420                 2425                 2430             


Leu Ser  Leu Gly Gly Asn Ser  Leu Lys Ala Thr Leu  Met Leu Ser 
    2435                 2440                 2445             


Lys Ile  Gln Gln Thr Phe Asn  Gln Lys Val Ser Ile  Gly Gln Phe 
    2450                 2455                 2460             


Phe Ser  His Gln Thr Val Lys  Glu Leu Ala Asn Phe  Ile Arg Gly 
    2465                 2470                 2475             


Glu Lys  Asn Val Lys Tyr Pro  Pro Met Lys Pro Val  Glu Gln Lys 
    2480                 2485                 2490             


Ala Phe  Tyr Arg Thr Ser Pro  Ala Gln Gln Arg Val  Tyr Phe Leu 
    2495                 2500                 2505             


His Gln  Met Glu Pro Asn Gln  Val Ser Gln Asn Met  Phe Gly Gln 
    2510                 2515                 2520             


Ile Ser  Ile Ile Gly Lys Tyr  Asp Glu Lys Ala Leu  Ile Ala Ser 
    2525                 2530                 2535             


Leu Gln  Gln Val Met Gln Arg  His Glu Ala Phe Arg  Thr Ser Phe 
    2540                 2545                 2550             


His Ile  Ile Asp Gly Glu Ile  Val Gln Gln Ile Ala  Gly Glu Leu 
    2555                 2560                 2565             


Asp Phe  Asn Val Arg Val His  Ser Met Asp Arg Glu  Glu Phe Glu 
    2570                 2575                 2580             


Ala Tyr  Ala Asp Gly Tyr Val  Lys Pro Phe Arg Leu  Glu Gln Ala 
    2585                 2590                 2595             


Pro Leu  Val Arg Ala Glu Leu  Ile Lys Val Asp Asn  Glu Gln Ala 
    2600                 2605                 2610             


Glu Leu  Leu Ile Asp Met His  His Ile Ile Ser Asp  Gly Tyr Ser 
    2615                 2620                 2625             


Met Ser  Ile Leu Thr Asn Glu  Leu Phe Ala Leu Tyr  His Gly Asn 
    2630                 2635                 2640             


Pro Leu  Pro Glu Ile Pro Phe  Glu Tyr Lys Asp Phe  Ala Glu Trp 
    2645                 2650                 2655             


Gln Asn  Gln Leu Leu Ile Gly  Glu Val Met Glu Gln  Gln Glu Glu 
    2660                 2665                 2670             


Tyr Trp  Leu Glu Gln Phe Lys  Gln Glu Val Pro Ile  Leu Gln Leu 
    2675                 2680                 2685             


Pro Ala  Asp Gly Ser Arg Ala  Met Glu Trp Ser Ser  Glu Gly Gln 
    2690                 2695                 2700             


Arg Val  Thr Cys Ser Leu Gln  Ser Ser Leu Ile Arg  Ser Leu Gln 
    2705                 2710                 2715             


Glu Met  Ala Gln Gln Lys Gly  Thr Thr Leu Tyr Met  Val Leu Leu 
    2720                 2725                 2730             


Ala Ala  Tyr Asn Val Leu Leu  His Lys Tyr Thr Gly  Gln Glu Asp 
    2735                 2740                 2745             


Ile Val  Val Gly Thr Pro Val  Ser Gly Arg Asn Gln  Pro Asn Ile 
    2750                 2755                 2760             


Glu Ser  Met Ile Gly Ile Phe  Ile Gln Thr Met Gly  Ile Arg Thr 
    2765                 2770                 2775             


Lys Pro  Gln Ala Asn Lys Arg  Phe Thr Asp Tyr Leu  Asp Glu Val 
    2780                 2785                 2790             


Lys Arg  Gln Thr Leu Asp Ala  Phe Glu Asn Gln Asp  Tyr Pro Phe 
    2795                 2800                 2805             


Asp Trp  Leu Val Glu Lys Val  Asn Val Gln Arg Glu  Thr Thr Gly 
    2810                 2815                 2820             


Lys Ser  Leu Phe Asn Thr Met  Phe Val Tyr Gln Asn  Ile Glu Phe 
    2825                 2830                 2835             


Gln Glu  Ile His Gln Asp Gly  Cys Thr Phe Arg Val  Lys Glu Arg 
    2840                 2845                 2850             


Asn Pro  Gly Val Ser Leu Tyr  Asp Leu Met Leu Thr  Ile Glu Asp 
    2855                 2860                 2865             


Ala Glu  Lys Gln Leu Asp Ile  His Phe Asp Phe Asn  Pro Asn Gln 
    2870                 2875                 2880             


Phe Glu  Gln Glu Thr Ile Glu  Gln Ile Ile Arg His  Tyr Thr Ser 
    2885                 2890                 2895             


Leu Leu  Asp Ser Leu Val Lys  Glu Pro Glu Lys Ser  Leu Ser Ser 
    2900                 2905                 2910             


Val Pro  Met Leu Ser Asp Ile  Glu Arg His Gln Leu  Leu Met Gly 
    2915                 2920                 2925             


Cys Asn  Asp Thr Glu Thr Pro  Phe Pro His Asn Asp  Thr Val Cys 
    2930                 2935                 2940             


Gln Trp  Phe Glu Thr Gln Ala  Glu Gln Arg Pro Asp  Asp Glu Ala 
    2945                 2950                 2955             


Val Ile  Phe Gly Asn Glu Arg  Cys Thr Tyr Gly Gln  Leu Asn Glu 
    2960                 2965                 2970             


Arg Val  Asn Gln Leu Ala Arg  Thr Leu Arg Thr Lys  Gly Val Gln 
    2975                 2980                 2985             


Ala Asp  Gln Phe Val Ala Ile  Ile Cys Pro His Arg  Ile Glu Leu 
    2990                 2995                 3000             


Ile Val  Gly Ile Leu Ala Val  Leu Lys Ala Gly Gly  Ala Tyr Val 
    3005                 3010                 3015             


Pro Ile  Asp Pro Glu Tyr Pro  Glu Asp Arg Ile Gln  Tyr Met Leu 
    3020                 3025                 3030             


Lys Asp  Ser Glu Ala Lys Ile  Val Leu Ala Gln Leu  Asp Leu His 
    3035                 3040                 3045             


Lys His  Leu Thr Phe Asp Ala  Asp Val Val Leu Leu  Asp Glu Glu 
    3050                 3055                 3060             


Ser Ser  Tyr His Glu Asp Arg  Ser Asn Leu Glu Pro  Thr Cys Gly 
    3065                 3070                 3075             


Ala Asn  Asp Leu Ala Tyr Met  Ile Tyr Thr Ser Gly  Ser Thr Gly 
    3080                 3085                 3090             


Asn Pro  Lys Gly Val Leu Ile  Glu His Arg Gly Leu  Ala Asn Tyr 
    3095                 3100                 3105             


Ile Glu  Trp Ala Lys Glu Val  Tyr Val Asn Asp Glu  Lys Thr Asn 
    3110                 3115                 3120             


Phe Pro  Leu Tyr Ser Ser Ile  Ser Phe Asp Leu Thr  Val Thr Ser 
    3125                 3130                 3135             


Ile Phe  Thr Pro Leu Val Thr  Gly Asn Thr Ile Ile  Val Phe Asp 
    3140                 3145                 3150             


Gly Glu  Asp Lys Ser Ala Val  Leu Ser Thr Ile Met  Gln Asp Pro 
    3155                 3160                 3165             


Arg Ile  Asp Ile Ile Lys Leu  Thr Pro Ala His Leu  His Val Leu 
    3170                 3175                 3180             


Lys Glu  Met Lys Ile Ala Asp  Gly Thr Thr Ile Arg  Lys Met Ile 
    3185                 3190                 3195             


Val Gly  Gly Glu Asn Leu Ser  Thr Arg Leu Ala Gln  Ser Val Ser 
    3200                 3205                 3210             


Glu Gln  Phe Lys Gly Gln Leu  Asp Ile Phe Asn Glu  Tyr Gly Pro 
    3215                 3220                 3225             


Thr Glu  Ala Val Val Gly Cys  Met Ile Tyr Arg Tyr  Asp Thr Lys 
    3230                 3235                 3240             


Arg Asp  Arg Arg Glu Phe Val  Pro Ile Gly Ser Pro  Ala Ala Asn 
    3245                 3250                 3255             


Thr Ser  Ile Tyr Val Leu Asp  Ala Ser Met Asn Leu  Val Pro Val 
    3260                 3265                 3270             


Gly Val  Pro Gly Glu Met Tyr  Ile Gly Gly Ala Gly  Val Ala Arg 
    3275                 3280                 3285             


Gly Tyr  Trp Asn Arg Pro Asp  Leu Thr Ala Glu Lys  Phe Val His 
    3290                 3295                 3300             


Asn Pro  Phe Ala Pro Gly Thr  Ile Met Tyr Lys Thr  Gly Asp Leu 
    3305                 3310                 3315             


Ala Lys  Arg Leu Arg Asp Gly  Asn Leu Ile Tyr Leu  Gly Arg Ile 
    3320                 3325                 3330             


Asp Glu  Gln Val Lys Ile Arg  Gly His Arg Ile Glu  Leu Gly Glu 
    3335                 3340                 3345             


Val Glu  Ala Ala Met His Lys  Val Glu Ala Val Gln  Lys Ala Val 
    3350                 3355                 3360             


Val Leu  Ala Arg Glu Glu Glu  Asp Gly Leu Gln Gln  Leu Cys Ala 
    3365                 3370                 3375             


Tyr Tyr  Val Ser Asn Lys Pro  Ile Thr Ile Ala Glu  Ile Arg Glu 
    3380                 3385                 3390             


Gln Leu  Ser Leu Glu Leu Pro  Asp Tyr Met Val Pro  Ser His Tyr 
    3395                 3400                 3405             


Ile Gln  Leu Glu Gln Leu Pro  Leu Thr Ser Asn Gly  Lys Ile Asn 
    3410                 3415                 3420             


Arg Lys  Ala Leu Pro Ala Pro  Glu Val Ser Leu Glu  Gln Ile Ala 
    3425                 3430                 3435             


Glu Tyr  Val Pro Pro Gly Asn  Glu Val Glu Ser Lys  Leu Ala Val 
    3440                 3445                 3450             


Leu Trp  Gln Glu Met Leu Gly  Ile His Arg Val Gly  Ile Lys His 
    3455                 3460                 3465             


Asn Phe  Phe Asp Leu Gly Gly  Asn Ser Ile Arg Ala  Thr Ala Leu 
    3470                 3475                 3480             


Ala Ala  Arg Ile His Lys Glu  Leu Asp Val Asn Leu  Ser Val Lys 
    3485                 3490                 3495             


Asp Ile  Phe Lys Phe Pro Thr  Ile Glu Gln Leu Ala  Asn Met Ala 
    3500                 3505                 3510             


Leu Arg  Met Glu Lys Ile Arg  Tyr Val Ser Ile Pro  Ser Ala Gln 
    3515                 3520                 3525             


Lys Ile  Ser Tyr Tyr Pro Val  Ser Ser Ala Gln Lys  Arg Met Tyr 
    3530                 3535                 3540             


Leu Leu  Ser His Thr Glu Gly  Gly Glu Leu Thr Tyr  Asn Met Thr 
    3545                 3550                 3555             


Gly Ala  Met Ser Val Glu Gly  Ala Ile Asp Leu Glu  Arg Leu Thr 
    3560                 3565                 3570             


Ala Ala  Phe Gln Lys Leu Ile  Glu Arg His Glu Val  Leu Arg Thr 
    3575                 3580                 3585             


Ser Phe  Glu Leu Tyr Glu Gly  Glu Pro Ala Gln Arg  Ile His Pro 
    3590                 3595                 3600             


Ser Ile  Glu Phe Thr Ile Glu  Gln Ile Gln Ala Arg  Glu Glu Glu 
    3605                 3610                 3615             


Val Glu  Asp His Val Leu Asp  Phe Ile Lys Ser Phe  Asp Leu Ala 
    3620                 3625                 3630             


Lys Pro  Pro Leu Met Arg Val  Gly Leu Ile Glu Leu  Thr Pro Glu 
    3635                 3640                 3645             


Lys His  Val Leu Leu Val Asp  Met His His Ile Ile  Ser Asp Gly 
    3650                 3655                 3660             


Val Ser  Met Asn Ile Leu Met  Lys Asp Leu Asn Gln  Phe Tyr Lys 
    3665                 3670                 3675             


Gly Ile  Glu Pro Asp Pro Leu  Pro Ile Gln Tyr Lys  Asp Tyr Ala 
    3680                 3685                 3690             


Val Trp  Gln Gln Thr Glu Ala  Gln Arg Gln Asn Ile  Lys Lys Gln 
    3695                 3700                 3705             


Glu Ala  Tyr Trp Leu Asn Arg  Phe His Asp Glu Ile  Pro Val Leu 
    3710                 3715                 3720             


Asp Met  Pro Thr Asp Tyr Glu  Arg Pro Ala Ile Arg  Asp Tyr Glu 
    3725                 3730                 3735             


Gly Glu  Ser Phe Glu Phe Leu  Ile Pro Ile Glu Leu  Lys Gln Arg 
    3740                 3745                 3750             


Leu Ser  Gln Met Glu Glu Ala  Thr Gly Thr Thr Leu  Tyr Met Ile 
    3755                 3760                 3765             


Leu Met  Ala Ala Tyr Thr Ile  Leu Leu Ser Lys Tyr  Ser Gly Gln 
    3770                 3775                 3780             


Glu Asp  Ile Val Val Gly Thr  Pro Val Ser Gly Arg  Ser His Met 
    3785                 3790                 3795             


Asp Val  Glu Ser Val Val Gly  Met Phe Val Asn Thr  Leu Val Ile 
    3800                 3805                 3810             


Arg Asn  His Pro Ala Gly Arg  Lys Ile Phe Glu Asp  Tyr Leu Asn 
    3815                 3820                 3825             


Glu Val  Lys Glu Asn Met Leu  Asn Ala Tyr Gln Asn  Gln Asp Tyr 
    3830                 3835                 3840             


Pro Leu  Glu Glu Leu Ile Gln  His Val His Leu Leu  Lys Asp Ser 
    3845                 3850                 3855             


Ser Arg  Asn Pro Leu Phe Asp  Thr Met Phe Val Leu  Gln Asn Leu 
    3860                 3865                 3870             


Asp Gln  Val Glu Leu Asn Leu  Asp Ser Leu Arg Phe  Thr Pro Tyr 
    3875                 3880                 3885             


Lys Leu  His His Thr Val Ala  Lys Phe Asp Leu Thr  Leu Ser Ile 
    3890                 3895                 3900             


Gln Thr  Asp Gln Asp Lys His  His Gly Leu Phe Glu  Tyr Ser Lys 
    3905                 3910                 3915             


Lys Leu  Phe Lys Lys Ser Arg  Ile Glu Ala Leu Ser  Lys Asp Tyr 
    3920                 3925                 3930             


Leu His  Ile Leu Ser Val Ile  Ser Gln Gln Pro Ser  Ile Gln Ile 
    3935                 3940                 3945             


Glu His  Ile Glu Leu Ser Gly  Ser Thr Ala Glu Asp  Asp Asn Leu 
    3950                 3955                 3960             


Ile His  Ser Ile Glu Leu Asn  Phe 
    3965                 3970     


<210> 11
<211> 294
<212> DNA
<213> Bacillus subtilis

<400> 11
atccggaatg cgctggctat cgacttaaaa gatactcttt tatcttggat gcccttaacc       60

catgacatgg ggctcatagc ttgccacctt gttcctgcct tagccggaat caatcaaaat      120

ttaatgccga cagaattatt tattcgaaga cctattctct ggatgaaaaa agctcatgaa      180

cataaagcca gcattctatc ctcacctaat tttggataca attactttct taaatttctg      240

aaagacaata aaagttacga ctgggattta tcccatatca gggtcattgc aaac            294


<210> 12
<211> 98
<212> PRT
<213> Bacillus subtilis

<400> 12
Ile Arg Asn Ala Leu Ala Ile Asp Leu Lys Asp Thr Leu Leu Ser Trp 
1               5                   10                  15      


Met Pro Leu Thr His Asp Met Gly Leu Ile Ala Cys His Leu Val Pro 
            20                  25                  30          


Ala Leu Ala Gly Ile Asn Gln Asn Leu Met Pro Thr Glu Leu Phe Ile 
        35                  40                  45              


Arg Arg Pro Ile Leu Trp Met Lys Lys Ala His Glu His Lys Ala Ser 
    50                  55                  60                  


Ile Leu Ser Ser Pro Asn Phe Gly Tyr Asn Tyr Phe Leu Lys Phe Leu 
65                  70                  75                  80  


Lys Asp Asn Lys Ser Tyr Asp Trp Asp Leu Ser His Ile Arg Val Ile 
                85                  90                  95      


Ala Asn 
        


<210> 13
<211> 1794
<212> DNA
<213> Streptomyces roseosporus

<400> 13
gtgagtgaga gccgctgtgc cgggcagggc ctggtggggg cactgcggac ctgggcacgg       60

acacgtgccc gggagactgc cgtggttctc gtacgggaca ccggaaccac cgacgacacg      120

gcgtcggtgg actacggaca gctggacgag tgggccagaa gcatcgcggt gaccctccga      180

cagcaactcg cgccgggggg acgggcactt ctgctgctgc cgtccggccc ggagttcacg      240

gccgcgtacc tcggctgcct gtacgcgggt ctggccgccg taccggcgcc gctgcccggg      300

gggcgccact tcgaacgccg ccgtgtcgcg gccatcgccg ccgacagcgg agccggcgtg      360

gtgctgaccg tcgcgggtga gaccgcctcc gtccacgact ggctgaccga gaccacggcc      420

ccggctactc gcgtcgtggc cgtggacgac cgggcggcgc tcggcgaccc ggcgcagtgg      480

gacgacccgg gcgtcgcgcc cgacgacgtg gctctcatcc agtacacctc gggctcgacc      540

ggcaacccca agggcgtggt cgtgacccac gccaacctgc tggcgaacgc gcggaatctc      600

gccgaggcct gcgagctgac cgccgccact cccatgggcg gctggctgcc catgtaccac      660

gacatggggc tcctgggcac gctgacaccg gccctgtacc tcggcaccac gtgcgtgctg      720

atgagctcca cggcattcat caaacggccg cacctgtggc tacggaccat cgaccggttc      780

ggcctggtct ggtcgtcggc tcccgacttc gcgtacgaca tgtgtctgaa gcgcgtcacc      840

gacgagcaga tcgccgggct ggacctgtcc cgctggcggt gggccggcaa cggcgcggag      900

cccatccggg cagccaccgt acgggccttc ggcgaacggt tcgcccggta cggcctgcgc      960

cccgaggcgc tcaccgccgg ctacgggctg gccgaggcca ccctgttcgt gtcgaggtcg     1020

caggggctgc acacggcacg agtcgccacc gccgccctcg aacgccacga attccgcctc     1080

gccgtacccg gcgaggcagc ccgggagatc gtcagctgcg gtcccgtcgg ccacttccgc     1140

gcccgcatcg tcgaacccgg cgggcaccgt gttctgccgc ccggccaggt cggcgagctg     1200

gtcctccagg gagccgccgt ctgcgccggc tactggcagg ccaaggagga gaccgagcag     1260

accttcggcc tcaccctcga cggcgaggac ggtcactggc tgcgcaccgg cgatctcgcc     1320

gccctgcacg aagggaatct ccacatcacc ggccgctgca aagaggccct ggtgatacga     1380

ggacgcaatc tgtacccgca ggacatcgag cacgaactcc gcctgcaaca cccggaactt     1440

gagagcgtcg gcgccgcgtt caccgtcccg gcggcacctg gcacgccggg cttgatggtg     1500

gtccacgaag tccgcacccc ggtccccgcc gacgaccacc cggccctggt cagcgccctg     1560

cgggggacga tcaaccgcga attcggactc gacgcccagg gcatcgccct ggtgagccgc     1620

ggcaccgtac tgcgtaccac cagcggcaag gtccgccggg gcgccatgcg tgacctctgc     1680

ctccgcgggg agctgaacat cgtccacgcg gacaagggct ggcacgccat cgccggcacg     1740

gccggagagg acatcgcccc cactgaccac gctccacatc cgcaccccgc gtaa           1794


<210> 14
<211> 597
<212> PRT
<213> Streptomyces roseosporus

<400> 14
Met Ser Glu Ser Arg Cys Ala Gly Gln Gly Leu Val Gly Ala Leu Arg 
1               5                   10                  15      


Thr Trp Ala Arg Thr Arg Ala Arg Glu Thr Ala Val Val Leu Val Arg 
            20                  25                  30          


Asp Thr Gly Thr Thr Asp Asp Thr Ala Ser Val Asp Tyr Gly Gln Leu 
        35                  40                  45              


Asp Glu Trp Ala Arg Ser Ile Ala Val Thr Leu Arg Gln Gln Leu Ala 
    50                  55                  60                  


Pro Gly Gly Arg Ala Leu Leu Leu Leu Pro Ser Gly Pro Glu Phe Thr 
65                  70                  75                  80  


Ala Ala Tyr Leu Gly Cys Leu Tyr Ala Gly Leu Ala Ala Val Pro Ala 
                85                  90                  95      


Pro Leu Pro Gly Gly Arg His Phe Glu Arg Arg Arg Val Ala Ala Ile 
            100                 105                 110         


Ala Ala Asp Ser Gly Ala Gly Val Val Leu Thr Val Ala Gly Glu Thr 
        115                 120                 125             


Ala Ser Val His Asp Trp Leu Thr Glu Thr Thr Ala Pro Ala Thr Arg 
    130                 135                 140                 


Val Val Ala Val Asp Asp Arg Ala Ala Leu Gly Asp Pro Ala Gln Trp 
145                 150                 155                 160 


Asp Asp Pro Gly Val Ala Pro Asp Asp Val Ala Leu Ile Gln Tyr Thr 
                165                 170                 175     


Ser Gly Ser Thr Gly Asn Pro Lys Gly Val Val Val Thr His Ala Asn 
            180                 185                 190         


Leu Leu Ala Asn Ala Arg Asn Leu Ala Glu Ala Cys Glu Leu Thr Ala 
        195                 200                 205             


Ala Thr Pro Met Gly Gly Trp Leu Pro Met Tyr His Asp Met Gly Leu 
    210                 215                 220                 


Leu Gly Thr Leu Thr Pro Ala Leu Tyr Leu Gly Thr Thr Cys Val Leu 
225                 230                 235                 240 


Met Ser Ser Thr Ala Phe Ile Lys Arg Pro His Leu Trp Leu Arg Thr 
                245                 250                 255     


Ile Asp Arg Phe Gly Leu Val Trp Ser Ser Ala Pro Asp Phe Ala Tyr 
            260                 265                 270         


Asp Met Cys Leu Lys Arg Val Thr Asp Glu Gln Ile Ala Gly Leu Asp 
        275                 280                 285             


Leu Ser Arg Trp Arg Trp Ala Gly Asn Gly Ala Glu Pro Ile Arg Ala 
    290                 295                 300                 


Ala Thr Val Arg Ala Phe Gly Glu Arg Phe Ala Arg Tyr Gly Leu Arg 
305                 310                 315                 320 


Pro Glu Ala Leu Thr Ala Gly Tyr Gly Leu Ala Glu Ala Thr Leu Phe 
                325                 330                 335     


Val Ser Arg Ser Gln Gly Leu His Thr Ala Arg Val Ala Thr Ala Ala 
            340                 345                 350         


Leu Glu Arg His Glu Phe Arg Leu Ala Val Pro Gly Glu Ala Ala Arg 
        355                 360                 365             


Glu Ile Val Ser Cys Gly Pro Val Gly His Phe Arg Ala Arg Ile Val 
    370                 375                 380                 


Glu Pro Gly Gly His Arg Val Leu Pro Pro Gly Gln Val Gly Glu Leu 
385                 390                 395                 400 


Val Leu Gln Gly Ala Ala Val Cys Ala Gly Tyr Trp Gln Ala Lys Glu 
                405                 410                 415     


Glu Thr Glu Gln Thr Phe Gly Leu Thr Leu Asp Gly Glu Asp Gly His 
            420                 425                 430         


Trp Leu Arg Thr Gly Asp Leu Ala Ala Leu His Glu Gly Asn Leu His 
        435                 440                 445             


Ile Thr Gly Arg Cys Lys Glu Ala Leu Val Ile Arg Gly Arg Asn Leu 
    450                 455                 460                 


Tyr Pro Gln Asp Ile Glu His Glu Leu Arg Leu Gln His Pro Glu Leu 
465                 470                 475                 480 


Glu Ser Val Gly Ala Ala Phe Thr Val Pro Ala Ala Pro Gly Thr Pro 
                485                 490                 495     


Gly Leu Met Val Val His Glu Val Arg Thr Pro Val Pro Ala Asp Asp 
            500                 505                 510         


His Pro Ala Leu Val Ser Ala Leu Arg Gly Thr Ile Asn Arg Glu Phe 
        515                 520                 525             


Gly Leu Asp Ala Gln Gly Ile Ala Leu Val Ser Arg Gly Thr Val Leu 
    530                 535                 540                 


Arg Thr Thr Ser Gly Lys Val Arg Arg Gly Ala Met Arg Asp Leu Cys 
545                 550                 555                 560 


Leu Arg Gly Glu Leu Asn Ile Val His Ala Asp Lys Gly Trp His Ala 
                565                 570                 575     


Ile Ala Gly Thr Ala Gly Glu Asp Ile Ala Pro Thr Asp His Ala Pro 
            580                 585                 590         


His Pro His Pro Ala 
        595         


<210> 15
<211> 294
<212> DNA
<213> Streptomyces roseosporus

<400> 15
ctcgccgagg cctgcgagct gaccgccgcc actcccatgg gcggctggct gcccatgtac       60

cacgacatgg ggctcctggg cacgctgaca ccggccctgt acctcggcac cacgtgcgtg      120

ctgatgagct ccacggcatt catcaaacgg ccgcacctgt ggctacggac catcgaccgg      180

ttcggcctgg tctggtcgtc ggctcccgac ttcgcgtacg acatgtgtct gaagcgcgtc      240

accgacgagc agatcgccgg gctggacctg tcccgctggc ggtgggccgg caac            294


<210> 16
<211> 98
<212> PRT
<213> Streptomyces roseosporus

<400> 16
Leu Ala Glu Ala Cys Glu Leu Thr Ala Ala Thr Pro Met Gly Gly Trp 
1               5                   10                  15      


Leu Pro Met Tyr His Asp Met Gly Leu Leu Gly Thr Leu Thr Pro Ala 
            20                  25                  30          


Leu Tyr Leu Gly Thr Thr Cys Val Leu Met Ser Ser Thr Ala Phe Ile 
        35                  40                  45              


Lys Arg Pro His Leu Trp Leu Arg Thr Ile Asp Arg Phe Gly Leu Val 
    50                  55                  60                  


Trp Ser Ser Ala Pro Asp Phe Ala Tyr Asp Met Cys Leu Lys Arg Val 
65                  70                  75                  80  


Thr Asp Glu Gln Ile Ala Gly Leu Asp Leu Ser Arg Trp Arg Trp Ala 
                85                  90                  95      


Gly Asn 
        


<210> 17
<211> 8163
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
atggttggtc aatttgcaaa tttcgtcgat ctgctccagt acagagctaa acttcaggcg       60

cggaaaaccg tgtttagttt tctggctgat ggcgaagcgg aatctgcggc cctgacctac      120

ggagaattag accaaaaagc ccaggcgatc gccgcttttt tgcaagctaa ccaggctcaa      180

gggcaacggg cattattact ttatccaccg ggtttagagt ttatcggtgc ctttttggga      240

tgtttgtatg ctggtgttgt tgcggtgcca gcttacccac cacggccgaa taaatccttt      300

gaccgcctcc atagcattat ccaagatgcc caggcaaaat ttgccctcac cacaacagaa      360

cttaaagata aaattgccga tcgcctcgaa gctttagaag gtacggattt tcattgtttg      420

gctacagatc aagttgaatt aatttcagga aaaaattggc aaaaaccgaa catttccggc      480

acagatctcg cttttttgca atacaccagt ggctccacgg gcgatcctaa aggagtgatg      540

gtttcccacc acaatttgat ccacaactcc ggcttgattt ttacctcttt tcatatgaat      600

gatgaaacca ttattttcag ctggctgccc ccacatcatg atatgggttt gattggctgc      660

attctgaccc ccatctatgg tggaattcag gcaatcatga tgtccccttt ctcattttta      720

caaaacccgc tttcctggtt aaaacatatt accaaataca aagcaactat cagtggaagc      780

cctaacttcg cttacgatta ttgtgtcaaa cgaatcaggg aagaaaaaaa agaagggctg      840

gatttaagtt catgggtgac tgctttcaac ggggccgaac cgatccgcgc tgtgaccctc      900

gaaaattttg cgaaaacctt cgctacagca ggctttcaaa aatcagcatt ttatccctgt      960

tatggtatgg ctgaaaccac cctgatcgtt tccggtggta atggtcgtgc ccagcttccc     1020

caggaaatta tcgtcagcaa acagggcatc gaagcaaacc aagttcgccc tgcccaaggg     1080

acagaaacaa cggtgacctt ggtcggcagt ggtgaagtga ttggcgacca aattgtcaaa     1140

attgttgacc cccaggcttt aacagaatgt accgtcggtg aaattggcga agtatgggtt     1200

aagggcgaaa gtgttgccca gggctattgg caaaagccag acctcaccca gcaacaattc     1260

cagggaaacg tcggtgcaga aacgggcttt ttacgcacgg gcgatctggg ttttttgcaa     1320

ggtggcgaac tgtatattac gggtcgttta aaggatctcc tgattatccg ggggcgcaac     1380

cactatcccc aggacattga attaaccgtc gaagtggccc atcccgcttt acgacagggg     1440

gccggagccg ctgtatcagt agacgttaac ggggaagaac agttagtcat tgtccaggaa     1500

gttgagcgta aatatgcccg caaattaaat gtcgcggcag tagcccaagc tattcgtggg     1560

gcgatcgccg ccgaacatca actgcaaccc caggccattt gttttattaa acccggtagc     1620

attcccaaaa catccagcgg gaagattcgt cgccatgcct gcaaagctgg ttttctagac     1680

ggaagcttgg ctgtggttgg ggagtggcaa cccagccacc aaaaagaagg aaaaggaatt     1740

gggacacaag ccgttacccc ttctacgaca acatcaacga attttcccct gcctgaccag     1800

caccaacagc aaattgaagc ctggcttaag gataatattg cccatcgcct cggcattacg     1860

ccccaacaat tagacgaaac ggaacccttt gcaagttatg ggctggattc agtgcaagca     1920

gtacaggtca cagccgactt agaggattgg ctaggtcgaa aattagaccc cactctggcc     1980

tacgattatc cgaccattcg caccctggct cagtttttgg tccagggtaa tcaagcgcta     2040

gagaaaatac cacaggtgcc gaaaattcag ggcaaagaaa ttgccgtggt gggtctcagt     2100

tgtcgttttc cccaagctga caaccccgaa gctttttggg aattattacg taatggtaaa     2160

gatggagttc gcccccttaa aactcgctgg gccacgggag aatggggtgg ttttttagaa     2220

gatattgacc agtttgagcc gcaatttttt ggcatttccc cccgggaagc ggaacaaatg     2280

gatccccagc aacgcttact gttagaagta acctgggaag ccttggaacg ggcaaatatt     2340

ccggcagaaa gtttacgcca ttcccaaacg ggggtttttg tcggcattag taatagtgat     2400

tatgcccagt tgcaggtgcg ggaaaacaat ccgatcaatc cctacatggg gacgggcaac     2460

gcccacagta ttgctgcgaa tcgtctgtct tatttcctcg atctccgggg cgtttctctg     2520

agcatcgata cggcctgttc ctcttctctg gtggcggtac atctggcctg tcaaagttta     2580

atcaacggcg aatcggagtt ggcgatcgcc gccggggtga atttgatttt gacccccgat     2640

gtgacccaga cttttaccca ggcgggcatg atgagtaaga cgggccgttg ccagaccttt     2700

gatgccgagg ctgatggcta tgtgcggggc gaaggttgtg gggtcgttct cctcaaaccc     2760

ctggcccagg cagaacggga cggggataat attctcgcgg tgatccacgg ttcggcggtg     2820

aatcaagatg gacgcagtaa cggtttgacg gctcccaacg ggcgatcgca acaggccgtt     2880

attcgccaag ccctggccca agccggcatt accgccgccg atttagctta cctagaggcc     2940

cacggcaccg gcacgcccct gggtgatccc attgaaatta attccctgaa ggcggtttta     3000

caaacggcgc agcgggaaca gccctgtgtg gtgggttctg tgaaaacaaa cattggtcac     3060

ctcgaggcag cggcgggcat cgcgggctta atcaaggtga ttttgtccct agagcatgga     3120

atgattcccc aacatttgca ttttaagcag ctcaatcccc gcattgatct agacggttta     3180

gtgaccattg cgagcaaaga tcagccttgg tcaggcgggt cacaaaaacg gtttgctggg     3240

gtaagttcct ttgggtttgg tggcaccaat gcccacgtga ttgtcgggga ctatgctcaa     3300

caaaaatctc cccttgctcc tccggctacc caagaccgcc cttggcattt gctgaccctt     3360

tctgctaaaa atgcccaggc cttaaatgcc ctgcaaaaaa gctatggaga ctatctggcc     3420

caacatccca gcgttgaccc acgcgatctc tgtttgtctg ccaataccgg gcgatcgccc     3480

ctcaaagaac gtcgtttttt tgtctttaaa caagtcgccg atttacaaca aactctcaat     3540

caagattttc tggcccaacc acgcctcagt tcccccgcaa aaattgcctt tttgtttacg     3600

gggcaaggtt cccaatacta cggcatgggg caacaactgt accaaaccag cccagtattt     3660

cggcaagtgc tggatgagtg cgatcgcctc tggcagacct attcccccga agcccctgcc     3720

ctcaccgacc tgctgtacgg taaccataac cctgacctcg tccacgaaac tgtctatacc     3780

cagcccctcc tctttgctgt tgaatatgcg atcgcccaac tatggttaag ctggggcgtg     3840

acgccagact tttgcatggg ccatagcgtc ggcgaatatg tcgcggcttg tctggcgggg     3900

gtattttccc tggcagacgg catgaaatta attacggccc ggggcaaact gatgcacgcc     3960

ctacccagca atggcagtat ggcggcggtc tttgccgata aaacggtcat caaaccctac     4020

ctatcggagc atttgaccgt cggagccgaa aacggttccc atttggtgct atcaggaaag     4080

accccctgcc tcgaagccag tattcacaaa ctccaaagcc aagggatcaa aaccaaaccc     4140

ctcaaggttt cccatgcttt ccactcccct ttgatggctc ccatgctggc agagtttcgg     4200

gaaattgctg aacaaattac tttccacccg ccgcgtatcc cgctcatttc caatgtcacg     4260

ggcggccaga ttgaagcgga aattgcccag gccgactatt gggttaagca cgtttcgcaa     4320

cccgtcaaat ttgtccagag catccaaacc ctggcccaag cgggtgtcaa tgtttatctc     4380

gaaatcggcg taaaaccagt gctcctgagt atgggacgcc attgcttagc tgaacaagaa     4440

gcggtttggt tgcccagttt acgtccccat agtgagcctt ggccggaaat tttgaccagt     4500

ctcggcaaac tgtatgagca agggctaaac attgactggc agaccgtgga agctggcgat     4560

cgccgccgga aactgattct gcccacctat cccttccaac ggcaacgata ttggtttaat     4620

caaggctctt ggcaaactgt tgagaccgaa tctgtgaacc caggccctga cgatctcaat     4680

gattggttgt atcaggtggc gtggacgccc ctggacactt tgcccccggc ccctgaaccg     4740

tcggctaagc tgtggttaat cttgggcgat cgccatgatc accagcccat tgaagcccaa     4800

tttaaaaacg cccagcgggt gtatctcggc caaagcaatc attttccgac gaatgccccc     4860

tgggaagtat ctgccgatgc gttggataat ttatttactc acgtcggctc ccaaaattta     4920

gcaggcatcc tttacctgtg tcccccaggg gaagacccag aagacctaga tgaaattcaa     4980

aagcaaacca gtggcttcgc cctccaactg atccaaaccc tgtatcaaca aaagatcgcg     5040

gttccctgct ggtttgtgac ccaccagagc caacgggtgc ttgaaaccga tgctgtcacc     5100

ggatttgccc aagggggatt atggggactc gcccaggcga tcgccctcga acatccagag     5160

ttgtgggggg gaattattga tgtcgatgac agcctgccaa attttgccca gatttgccaa     5220

caaagacagg tgcagcagtt ggccgtgcgg caccaaaaac tctacggggc acagctcaaa     5280

aagcaaccgt cactgcccca gaaaaatctc cagattcaac cccaacagac ctatctagtg     5340

acagggggac tgggggccat tggccgtaaa attgcccaat ggctagccgc agcaggagca     5400

gaaaaagtaa ttctcgtcag ccggcgcgct ccggcagcgg atcagcagac gttaccgacc     5460

aatgcggtgg tttatccttg cgatttagcc gacgcagccc aggtggcaaa gctgtttcaa     5520

acctatcccc acatcaaagg aattttccat gcggcgggta ccttagctga tggtttgctg     5580

caacaacaaa cttggcaaaa gttccagacc gtcgccgccg ccaaaatgaa agggacatgg     5640

catctgcacc gccatagtca aaagctcgat ctggattttt ttgtgttgtt ttcctctgtg     5700

gcaggggtgc tcggttcacc gggacagggg aattatgccg ccgcaaaccg gggcatggcg     5760

gcgatcgccc aatatcgaca agcccaaggt ttacccgccc tggcgatcca ttgggggcct     5820

tgggccgaag ggggaatggc caactccctc agcaaccaaa atttagcgtg gctgccgccc     5880

ccccagggac taacaatcct cgaaaaagtc ttgggcgccc agggggaaat gggggtcttt     5940

aaaccggact ggcaaaacct ggccaaacag ttccccgaat ttgccaaaac ccattacttt     6000

gcagccgtta ttccctctgc tgaggctgtg cccccaacgg cttcaatttt tgacaaatta     6060

atcaacctag aagcttctca gcgggctgac tatctactgg attatctgcg gcggtctgtg     6120

gcgcaaatcc tcaagttaga aattgagcaa attcaaagcc acgatagcct gttggatctg     6180

ggcatggatt cgttgatgat catggaggcg atcgccagcc tcaagcagga tttacaactg     6240

atgttgtacc ccagggaaat ctacgaacgg cccagacttg atgtgttgac ggcctatcta     6300

gcggcggaat tcaccaaggc ccatgattct gaagcagcaa cggcggcagc agcgattccc     6360

tcccaaagcc tttcggtcaa aacaaaaaaa cagtggcaaa aacctgacca caaaaacccg     6420

aatcccattg cctttatcct ctctagcccc cggtcgggtt cgacgttgct gcgggtgatg     6480

ttagccggac atccggggtt atattcgccg ccagagctgc atttgctccc ctttgagact     6540

atgggcgatc gccaccagga attgggtcta tcccacctcg gcgaagggtt acaacgggcc     6600

ttaatggatc tagaaaacct caccccagag gcaagccagg cgaaggtcaa ccaatgggtc     6660

aaagcgaata cacccattgc agacatctat gcctatctcc aacggcaggc ggaacaacgt     6720

ttactcatcg acaaatctcc cagctacggc agcgatcgcc atattctaga ccacagcgaa     6780

atcctctttg accaggccaa atatatccat ctggtacgcc atccctacgc ggtgattgaa     6840

tcctttaccc gactgcggat ggataaactg ctgggggccg agcagcagaa cccctacgcc     6900

ctcgcggagt ccatttggcg caccagcaac cgcaatattt tagacctggg tcgcacggtt     6960

ggtgcggatc gatatctcca ggtgatttac gaagatctcg tccgtgaccc ccgcaaagtt     7020

ttgacaaata tttgtgattt cctgggggtg gactttgacg aagcgctcct caatccctac     7080

agcggcgatc gccttaccga tggcctccac caacagtcca tgggcgtcgg ggatcccaat     7140

ttcctccagc acaaaaccat tgatccggcc ctcgccgaca aatggcgctc aattaccctg     7200

cccgctgctc tccagctgga tacgatccag ttggccgaaa cgtttgctta cgatctcccc     7260

caggaacccc agctaacacc ccagacccaa tccttgccct cgatggtgga gcggttcgtg     7320

acagtgcgcg gtttagaaac ctgtctctgt gagtggggcg atcgccacca accattggtg     7380

ctacttctcc acggcatcct cgaacagggg gcctcctggc aactcatcgc gccccagttg     7440

gcggcccagg gctattgggt tgtggcccca gacctgcgtg gtcacggcaa atccgcccat     7500

gcccagtcct acagcatgct tgattttttg gctgacgtag atgcccttgc caaacaatta     7560

ggcgatcgcc cctttacctt ggtgggccac tccatgggtt ccatcatcgg tgccatgtat     7620

gcaggaattc gccaaaccca ggtagaaaag ttgatcctcg ttgaaaccat tgtccccaac     7680

gacatcgacg acgctgaaac cggtaatcac ctgacgaccc atctcgatta cctcgccgcg     7740

cccccccaac acccgatctt ccccagccta gaagtggccg cccgtcgcct ccgccaagcc     7800

acgccccaac tacccaaaga cctctcggcg ttcctcaccc agcgcagcac caaatccgtc     7860

gaaaaagggg tgcagtggcg ttgggatgct ttcctccgta cccgggcggg cattgaattc     7920

aatggcatta gcagacgacg ttacctggcc ctgctcaaag atatccaagc gccgatcacc     7980

ctcatctatg gcgatcagag tgaatttaac cgccctgctg atctccaggc gatccaagcg     8040

gctctccccc aggcccaacg tttaacggtt gctggcggcc ataacctcca ttttgagaat     8100

ccccaggcga tcgcccaaat tgtttatcaa caactccaga cccctgtacc caaaacacaa     8160

taa                                                                   8163


<210> 18
<211> 2720
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Val Gly Gln Phe Ala Asn Phe Val Asp Leu Leu Gln Tyr Arg Ala 
1               5                   10                  15      


Lys Leu Gln Ala Arg Lys Thr Val Phe Ser Phe Leu Ala Asp Gly Glu 
            20                  25                  30          


Ala Glu Ser Ala Ala Leu Thr Tyr Gly Glu Leu Asp Gln Lys Ala Gln 
        35                  40                  45              


Ala Ile Ala Ala Phe Leu Gln Ala Asn Gln Ala Gln Gly Gln Arg Ala 
    50                  55                  60                  


Leu Leu Leu Tyr Pro Pro Gly Leu Glu Phe Ile Gly Ala Phe Leu Gly 
65                  70                  75                  80  


Cys Leu Tyr Ala Gly Val Val Ala Val Pro Ala Tyr Pro Pro Arg Pro 
                85                  90                  95      


Asn Lys Ser Phe Asp Arg Leu His Ser Ile Ile Gln Asp Ala Gln Ala 
            100                 105                 110         


Lys Phe Ala Leu Thr Thr Thr Glu Leu Lys Asp Lys Ile Ala Asp Arg 
        115                 120                 125             


Leu Glu Ala Leu Glu Gly Thr Asp Phe His Cys Leu Ala Thr Asp Gln 
    130                 135                 140                 


Val Glu Leu Ile Ser Gly Lys Asn Trp Gln Lys Pro Asn Ile Ser Gly 
145                 150                 155                 160 


Thr Asp Leu Ala Phe Leu Gln Tyr Thr Ser Gly Ser Thr Gly Asp Pro 
                165                 170                 175     


Lys Gly Val Met Val Ser His His Asn Leu Ile His Asn Ser Gly Leu 
            180                 185                 190         


Ile Phe Thr Ser Phe His Met Asn Asp Glu Thr Ile Ile Phe Ser Trp 
        195                 200                 205             


Leu Pro Pro His His Asp Met Gly Leu Ile Gly Cys Ile Leu Thr Pro 
    210                 215                 220                 


Ile Tyr Gly Gly Ile Gln Ala Ile Met Met Ser Pro Phe Ser Phe Leu 
225                 230                 235                 240 


Gln Asn Pro Leu Ser Trp Leu Lys His Ile Thr Lys Tyr Lys Ala Thr 
                245                 250                 255     


Ile Ser Gly Ser Pro Asn Phe Ala Tyr Asp Tyr Cys Val Lys Arg Ile 
            260                 265                 270         


Arg Glu Glu Lys Lys Glu Gly Leu Asp Leu Ser Ser Trp Val Thr Ala 
        275                 280                 285             


Phe Asn Gly Ala Glu Pro Ile Arg Ala Val Thr Leu Glu Asn Phe Ala 
    290                 295                 300                 


Lys Thr Phe Ala Thr Ala Gly Phe Gln Lys Ser Ala Phe Tyr Pro Cys 
305                 310                 315                 320 


Tyr Gly Met Ala Glu Thr Thr Leu Ile Val Ser Gly Gly Asn Gly Arg 
                325                 330                 335     


Ala Gln Leu Pro Gln Glu Ile Ile Val Ser Lys Gln Gly Ile Glu Ala 
            340                 345                 350         


Asn Gln Val Arg Pro Ala Gln Gly Thr Glu Thr Thr Val Thr Leu Val 
        355                 360                 365             


Gly Ser Gly Glu Val Ile Gly Asp Gln Ile Val Lys Ile Val Asp Pro 
    370                 375                 380                 


Gln Ala Leu Thr Glu Cys Thr Val Gly Glu Ile Gly Glu Val Trp Val 
385                 390                 395                 400 


Lys Gly Glu Ser Val Ala Gln Gly Tyr Trp Gln Lys Pro Asp Leu Thr 
                405                 410                 415     


Gln Gln Gln Phe Gln Gly Asn Val Gly Ala Glu Thr Gly Phe Leu Arg 
            420                 425                 430         


Thr Gly Asp Leu Gly Phe Leu Gln Gly Gly Glu Leu Tyr Ile Thr Gly 
        435                 440                 445             


Arg Leu Lys Asp Leu Leu Ile Ile Arg Gly Arg Asn His Tyr Pro Gln 
    450                 455                 460                 


Asp Ile Glu Leu Thr Val Glu Val Ala His Pro Ala Leu Arg Gln Gly 
465                 470                 475                 480 


Ala Gly Ala Ala Val Ser Val Asp Val Asn Gly Glu Glu Gln Leu Val 
                485                 490                 495     


Ile Val Gln Glu Val Glu Arg Lys Tyr Ala Arg Lys Leu Asn Val Ala 
            500                 505                 510         


Ala Val Ala Gln Ala Ile Arg Gly Ala Ile Ala Ala Glu His Gln Leu 
        515                 520                 525             


Gln Pro Gln Ala Ile Cys Phe Ile Lys Pro Gly Ser Ile Pro Lys Thr 
    530                 535                 540                 


Ser Ser Gly Lys Ile Arg Arg His Ala Cys Lys Ala Gly Phe Leu Asp 
545                 550                 555                 560 


Gly Ser Leu Ala Val Val Gly Glu Trp Gln Pro Ser His Gln Lys Glu 
                565                 570                 575     


Gly Lys Gly Ile Gly Thr Gln Ala Val Thr Pro Ser Thr Thr Thr Ser 
            580                 585                 590         


Thr Asn Phe Pro Leu Pro Asp Gln His Gln Gln Gln Ile Glu Ala Trp 
        595                 600                 605             


Leu Lys Asp Asn Ile Ala His Arg Leu Gly Ile Thr Pro Gln Gln Leu 
    610                 615                 620                 


Asp Glu Thr Glu Pro Phe Ala Ser Tyr Gly Leu Asp Ser Val Gln Ala 
625                 630                 635                 640 


Val Gln Val Thr Ala Asp Leu Glu Asp Trp Leu Gly Arg Lys Leu Asp 
                645                 650                 655     


Pro Thr Leu Ala Tyr Asp Tyr Pro Thr Ile Arg Thr Leu Ala Gln Phe 
            660                 665                 670         


Leu Val Gln Gly Asn Gln Ala Leu Glu Lys Ile Pro Gln Val Pro Lys 
        675                 680                 685             


Ile Gln Gly Lys Glu Ile Ala Val Val Gly Leu Ser Cys Arg Phe Pro 
    690                 695                 700                 


Gln Ala Asp Asn Pro Glu Ala Phe Trp Glu Leu Leu Arg Asn Gly Lys 
705                 710                 715                 720 


Asp Gly Val Arg Pro Leu Lys Thr Arg Trp Ala Thr Gly Glu Trp Gly 
                725                 730                 735     


Gly Phe Leu Glu Asp Ile Asp Gln Phe Glu Pro Gln Phe Phe Gly Ile 
            740                 745                 750         


Ser Pro Arg Glu Ala Glu Gln Met Asp Pro Gln Gln Arg Leu Leu Leu 
        755                 760                 765             


Glu Val Thr Trp Glu Ala Leu Glu Arg Ala Asn Ile Pro Ala Glu Ser 
    770                 775                 780                 


Leu Arg His Ser Gln Thr Gly Val Phe Val Gly Ile Ser Asn Ser Asp 
785                 790                 795                 800 


Tyr Ala Gln Leu Gln Val Arg Glu Asn Asn Pro Ile Asn Pro Tyr Met 
                805                 810                 815     


Gly Thr Gly Asn Ala His Ser Ile Ala Ala Asn Arg Leu Ser Tyr Phe 
            820                 825                 830         


Leu Asp Leu Arg Gly Val Ser Leu Ser Ile Asp Thr Ala Cys Ser Ser 
        835                 840                 845             


Ser Leu Val Ala Val His Leu Ala Cys Gln Ser Leu Ile Asn Gly Glu 
    850                 855                 860                 


Ser Glu Leu Ala Ile Ala Ala Gly Val Asn Leu Ile Leu Thr Pro Asp 
865                 870                 875                 880 


Val Thr Gln Thr Phe Thr Gln Ala Gly Met Met Ser Lys Thr Gly Arg 
                885                 890                 895     


Cys Gln Thr Phe Asp Ala Glu Ala Asp Gly Tyr Val Arg Gly Glu Gly 
            900                 905                 910         


Cys Gly Val Val Leu Leu Lys Pro Leu Ala Gln Ala Glu Arg Asp Gly 
        915                 920                 925             


Asp Asn Ile Leu Ala Val Ile His Gly Ser Ala Val Asn Gln Asp Gly 
    930                 935                 940                 


Arg Ser Asn Gly Leu Thr Ala Pro Asn Gly Arg Ser Gln Gln Ala Val 
945                 950                 955                 960 


Ile Arg Gln Ala Leu Ala Gln Ala Gly Ile Thr Ala Ala Asp Leu Ala 
                965                 970                 975     


Tyr Leu Glu Ala His Gly Thr Gly Thr Pro Leu Gly Asp Pro Ile Glu 
            980                 985                 990         


Ile Asn Ser Leu Lys Ala Val Leu  Gln Thr Ala Gln Arg  Glu Gln Pro 
        995                 1000                 1005             


Cys Val  Val Gly Ser Val Lys  Thr Asn Ile Gly His  Leu Glu Ala 
    1010                 1015                 1020             


Ala Ala  Gly Ile Ala Gly Leu  Ile Lys Val Ile Leu  Ser Leu Glu 
    1025                 1030                 1035             


His Gly  Met Ile Pro Gln His  Leu His Phe Lys Gln  Leu Asn Pro 
    1040                 1045                 1050             


Arg Ile  Asp Leu Asp Gly Leu  Val Thr Ile Ala Ser  Lys Asp Gln 
    1055                 1060                 1065             


Pro Trp  Ser Gly Gly Ser Gln  Lys Arg Phe Ala Gly  Val Ser Ser 
    1070                 1075                 1080             


Phe Gly  Phe Gly Gly Thr Asn  Ala His Val Ile Val  Gly Asp Tyr 
    1085                 1090                 1095             


Ala Gln  Gln Lys Ser Pro Leu  Ala Pro Pro Ala Thr  Gln Asp Arg 
    1100                 1105                 1110             


Pro Trp  His Leu Leu Thr Leu  Ser Ala Lys Asn Ala  Gln Ala Leu 
    1115                 1120                 1125             


Asn Ala  Leu Gln Lys Ser Tyr  Gly Asp Tyr Leu Ala  Gln His Pro 
    1130                 1135                 1140             


Ser Val  Asp Pro Arg Asp Leu  Cys Leu Ser Ala Asn  Thr Gly Arg 
    1145                 1150                 1155             


Ser Pro  Leu Lys Glu Arg Arg  Phe Phe Val Phe Lys  Gln Val Ala 
    1160                 1165                 1170             


Asp Leu  Gln Gln Thr Leu Asn  Gln Asp Phe Leu Ala  Gln Pro Arg 
    1175                 1180                 1185             


Leu Ser  Ser Pro Ala Lys Ile  Ala Phe Leu Phe Thr  Gly Gln Gly 
    1190                 1195                 1200             


Ser Gln  Tyr Tyr Gly Met Gly  Gln Gln Leu Tyr Gln  Thr Ser Pro 
    1205                 1210                 1215             


Val Phe  Arg Gln Val Leu Asp  Glu Cys Asp Arg Leu  Trp Gln Thr 
    1220                 1225                 1230             


Tyr Ser  Pro Glu Ala Pro Ala  Leu Thr Asp Leu Leu  Tyr Gly Asn 
    1235                 1240                 1245             


His Asn  Pro Asp Leu Val His  Glu Thr Val Tyr Thr  Gln Pro Leu 
    1250                 1255                 1260             


Leu Phe  Ala Val Glu Tyr Ala  Ile Ala Gln Leu Trp  Leu Ser Trp 
    1265                 1270                 1275             


Gly Val  Thr Pro Asp Phe Cys  Met Gly His Ser Val  Gly Glu Tyr 
    1280                 1285                 1290             


Val Ala  Ala Cys Leu Ala Gly  Val Phe Ser Leu Ala  Asp Gly Met 
    1295                 1300                 1305             


Lys Leu  Ile Thr Ala Arg Gly  Lys Leu Met His Ala  Leu Pro Ser 
    1310                 1315                 1320             


Asn Gly  Ser Met Ala Ala Val  Phe Ala Asp Lys Thr  Val Ile Lys 
    1325                 1330                 1335             


Pro Tyr  Leu Ser Glu His Leu  Thr Val Gly Ala Glu  Asn Gly Ser 
    1340                 1345                 1350             


His Leu  Val Leu Ser Gly Lys  Thr Pro Cys Leu Glu  Ala Ser Ile 
    1355                 1360                 1365             


His Lys  Leu Gln Ser Gln Gly  Ile Lys Thr Lys Pro  Leu Lys Val 
    1370                 1375                 1380             


Ser His  Ala Phe His Ser Pro  Leu Met Ala Pro Met  Leu Ala Glu 
    1385                 1390                 1395             


Phe Arg  Glu Ile Ala Glu Gln  Ile Thr Phe His Pro  Pro Arg Ile 
    1400                 1405                 1410             


Pro Leu  Ile Ser Asn Val Thr  Gly Gly Gln Ile Glu  Ala Glu Ile 
    1415                 1420                 1425             


Ala Gln  Ala Asp Tyr Trp Val  Lys His Val Ser Gln  Pro Val Lys 
    1430                 1435                 1440             


Phe Val  Gln Ser Ile Gln Thr  Leu Ala Gln Ala Gly  Val Asn Val 
    1445                 1450                 1455             


Tyr Leu  Glu Ile Gly Val Lys  Pro Val Leu Leu Ser  Met Gly Arg 
    1460                 1465                 1470             


His Cys  Leu Ala Glu Gln Glu  Ala Val Trp Leu Pro  Ser Leu Arg 
    1475                 1480                 1485             


Pro His  Ser Glu Pro Trp Pro  Glu Ile Leu Thr Ser  Leu Gly Lys 
    1490                 1495                 1500             


Leu Tyr  Glu Gln Gly Leu Asn  Ile Asp Trp Gln Thr  Val Glu Ala 
    1505                 1510                 1515             


Gly Asp  Arg Arg Arg Lys Leu  Ile Leu Pro Thr Tyr  Pro Phe Gln 
    1520                 1525                 1530             


Arg Gln  Arg Tyr Trp Phe Asn  Gln Gly Ser Trp Gln  Thr Val Glu 
    1535                 1540                 1545             


Thr Glu  Ser Val Asn Pro Gly  Pro Asp Asp Leu Asn  Asp Trp Leu 
    1550                 1555                 1560             


Tyr Gln  Val Ala Trp Thr Pro  Leu Asp Thr Leu Pro  Pro Ala Pro 
    1565                 1570                 1575             


Glu Pro  Ser Ala Lys Leu Trp  Leu Ile Leu Gly Asp  Arg His Asp 
    1580                 1585                 1590             


His Gln  Pro Ile Glu Ala Gln  Phe Lys Asn Ala Gln  Arg Val Tyr 
    1595                 1600                 1605             


Leu Gly  Gln Ser Asn His Phe  Pro Thr Asn Ala Pro  Trp Glu Val 
    1610                 1615                 1620             


Ser Ala  Asp Ala Leu Asp Asn  Leu Phe Thr His Val  Gly Ser Gln 
    1625                 1630                 1635             


Asn Leu  Ala Gly Ile Leu Tyr  Leu Cys Pro Pro Gly  Glu Asp Pro 
    1640                 1645                 1650             


Glu Asp  Leu Asp Glu Ile Gln  Lys Gln Thr Ser Gly  Phe Ala Leu 
    1655                 1660                 1665             


Gln Leu  Ile Gln Thr Leu Tyr  Gln Gln Lys Ile Ala  Val Pro Cys 
    1670                 1675                 1680             


Trp Phe  Val Thr His Gln Ser  Gln Arg Val Leu Glu  Thr Asp Ala 
    1685                 1690                 1695             


Val Thr  Gly Phe Ala Gln Gly  Gly Leu Trp Gly Leu  Ala Gln Ala 
    1700                 1705                 1710             


Ile Ala  Leu Glu His Pro Glu  Leu Trp Gly Gly Ile  Ile Asp Val 
    1715                 1720                 1725             


Asp Asp  Ser Leu Pro Asn Phe  Ala Gln Ile Cys Gln  Gln Arg Gln 
    1730                 1735                 1740             


Val Gln  Gln Leu Ala Val Arg  His Gln Lys Leu Tyr  Gly Ala Gln 
    1745                 1750                 1755             


Leu Lys  Lys Gln Pro Ser Leu  Pro Gln Lys Asn Leu  Gln Ile Gln 
    1760                 1765                 1770             


Pro Gln  Gln Thr Tyr Leu Val  Thr Gly Gly Leu Gly  Ala Ile Gly 
    1775                 1780                 1785             


Arg Lys  Ile Ala Gln Trp Leu  Ala Ala Ala Gly Ala  Glu Lys Val 
    1790                 1795                 1800             


Ile Leu  Val Ser Arg Arg Ala  Pro Ala Ala Asp Gln  Gln Thr Leu 
    1805                 1810                 1815             


Pro Thr  Asn Ala Val Val Tyr  Pro Cys Asp Leu Ala  Asp Ala Ala 
    1820                 1825                 1830             


Gln Val  Ala Lys Leu Phe Gln  Thr Tyr Pro His Ile  Lys Gly Ile 
    1835                 1840                 1845             


Phe His  Ala Ala Gly Thr Leu  Ala Asp Gly Leu Leu  Gln Gln Gln 
    1850                 1855                 1860             


Thr Trp  Gln Lys Phe Gln Thr  Val Ala Ala Ala Lys  Met Lys Gly 
    1865                 1870                 1875             


Thr Trp  His Leu His Arg His  Ser Gln Lys Leu Asp  Leu Asp Phe 
    1880                 1885                 1890             


Phe Val  Leu Phe Ser Ser Val  Ala Gly Val Leu Gly  Ser Pro Gly 
    1895                 1900                 1905             


Gln Gly  Asn Tyr Ala Ala Ala  Asn Arg Gly Met Ala  Ala Ile Ala 
    1910                 1915                 1920             


Gln Tyr  Arg Gln Ala Gln Gly  Leu Pro Ala Leu Ala  Ile His Trp 
    1925                 1930                 1935             


Gly Pro  Trp Ala Glu Gly Gly  Met Ala Asn Ser Leu  Ser Asn Gln 
    1940                 1945                 1950             


Asn Leu  Ala Trp Leu Pro Pro  Pro Gln Gly Leu Thr  Ile Leu Glu 
    1955                 1960                 1965             


Lys Val  Leu Gly Ala Gln Gly  Glu Met Gly Val Phe  Lys Pro Asp 
    1970                 1975                 1980             


Trp Gln  Asn Leu Ala Lys Gln  Phe Pro Glu Phe Ala  Lys Thr His 
    1985                 1990                 1995             


Tyr Phe  Ala Ala Val Ile Pro  Ser Ala Glu Ala Val  Pro Pro Thr 
    2000                 2005                 2010             


Ala Ser  Ile Phe Asp Lys Leu  Ile Asn Leu Glu Ala  Ser Gln Arg 
    2015                 2020                 2025             


Ala Asp  Tyr Leu Leu Asp Tyr  Leu Arg Arg Ser Val  Ala Gln Ile 
    2030                 2035                 2040             


Leu Lys  Leu Glu Ile Glu Gln  Ile Gln Ser His Asp  Ser Leu Leu 
    2045                 2050                 2055             


Asp Leu  Gly Met Asp Ser Leu  Met Ile Met Glu Ala  Ile Ala Ser 
    2060                 2065                 2070             


Leu Lys  Gln Asp Leu Gln Leu  Met Leu Tyr Pro Arg  Glu Ile Tyr 
    2075                 2080                 2085             


Glu Arg  Pro Arg Leu Asp Val  Leu Thr Ala Tyr Leu  Ala Ala Glu 
    2090                 2095                 2100             


Phe Thr  Lys Ala His Asp Ser  Glu Ala Ala Thr Ala  Ala Ala Ala 
    2105                 2110                 2115             


Ile Pro  Ser Gln Ser Leu Ser  Val Lys Thr Lys Lys  Gln Trp Gln 
    2120                 2125                 2130             


Lys Pro  Asp His Lys Asn Pro  Asn Pro Ile Ala Phe  Ile Leu Ser 
    2135                 2140                 2145             


Ser Pro  Arg Ser Gly Ser Thr  Leu Leu Arg Val Met  Leu Ala Gly 
    2150                 2155                 2160             


His Pro  Gly Leu Tyr Ser Pro  Pro Glu Leu His Leu  Leu Pro Phe 
    2165                 2170                 2175             


Glu Thr  Met Gly Asp Arg His  Gln Glu Leu Gly Leu  Ser His Leu 
    2180                 2185                 2190             


Gly Glu  Gly Leu Gln Arg Ala  Leu Met Asp Leu Glu  Asn Leu Thr 
    2195                 2200                 2205             


Pro Glu  Ala Ser Gln Ala Lys  Val Asn Gln Trp Val  Lys Ala Asn 
    2210                 2215                 2220             


Thr Pro  Ile Ala Asp Ile Tyr  Ala Tyr Leu Gln Arg  Gln Ala Glu 
    2225                 2230                 2235             


Gln Arg  Leu Leu Ile Asp Lys  Ser Pro Ser Tyr Gly  Ser Asp Arg 
    2240                 2245                 2250             


His Ile  Leu Asp His Ser Glu  Ile Leu Phe Asp Gln  Ala Lys Tyr 
    2255                 2260                 2265             


Ile His  Leu Val Arg His Pro  Tyr Ala Val Ile Glu  Ser Phe Thr 
    2270                 2275                 2280             


Arg Leu  Arg Met Asp Lys Leu  Leu Gly Ala Glu Gln  Gln Asn Pro 
    2285                 2290                 2295             


Tyr Ala  Leu Ala Glu Ser Ile  Trp Arg Thr Ser Asn  Arg Asn Ile 
    2300                 2305                 2310             


Leu Asp  Leu Gly Arg Thr Val  Gly Ala Asp Arg Tyr  Leu Gln Val 
    2315                 2320                 2325             


Ile Tyr  Glu Asp Leu Val Arg  Asp Pro Arg Lys Val  Leu Thr Asn 
    2330                 2335                 2340             


Ile Cys  Asp Phe Leu Gly Val  Asp Phe Asp Glu Ala  Leu Leu Asn 
    2345                 2350                 2355             


Pro Tyr  Ser Gly Asp Arg Leu  Thr Asp Gly Leu His  Gln Gln Ser 
    2360                 2365                 2370             


Met Gly  Val Gly Asp Pro Asn  Phe Leu Gln His Lys  Thr Ile Asp 
    2375                 2380                 2385             


Pro Ala  Leu Ala Asp Lys Trp  Arg Ser Ile Thr Leu  Pro Ala Ala 
    2390                 2395                 2400             


Leu Gln  Leu Asp Thr Ile Gln  Leu Ala Glu Thr Phe  Ala Tyr Asp 
    2405                 2410                 2415             


Leu Pro  Gln Glu Pro Gln Leu  Thr Pro Gln Thr Gln  Ser Leu Pro 
    2420                 2425                 2430             


Ser Met  Val Glu Arg Phe Val  Thr Val Arg Gly Leu  Glu Thr Cys 
    2435                 2440                 2445             


Leu Cys  Glu Trp Gly Asp Arg  His Gln Pro Leu Val  Leu Leu Leu 
    2450                 2455                 2460             


His Gly  Ile Leu Glu Gln Gly  Ala Ser Trp Gln Leu  Ile Ala Pro 
    2465                 2470                 2475             


Gln Leu  Ala Ala Gln Gly Tyr  Trp Val Val Ala Pro  Asp Leu Arg 
    2480                 2485                 2490             


Gly His  Gly Lys Ser Ala His  Ala Gln Ser Tyr Ser  Met Leu Asp 
    2495                 2500                 2505             


Phe Leu  Ala Asp Val Asp Ala  Leu Ala Lys Gln Leu  Gly Asp Arg 
    2510                 2515                 2520             


Pro Phe  Thr Leu Val Gly His  Ser Met Gly Ser Ile  Ile Gly Ala 
    2525                 2530                 2535             


Met Tyr  Ala Gly Ile Arg Gln  Thr Gln Val Glu Lys  Leu Ile Leu 
    2540                 2545                 2550             


Val Glu  Thr Ile Val Pro Asn  Asp Ile Asp Asp Ala  Glu Thr Gly 
    2555                 2560                 2565             


Asn His  Leu Thr Thr His Leu  Asp Tyr Leu Ala Ala  Pro Pro Gln 
    2570                 2575                 2580             


His Pro  Ile Phe Pro Ser Leu  Glu Val Ala Ala Arg  Arg Leu Arg 
    2585                 2590                 2595             


Gln Ala  Thr Pro Gln Leu Pro  Lys Asp Leu Ser Ala  Phe Leu Thr 
    2600                 2605                 2610             


Gln Arg  Ser Thr Lys Ser Val  Glu Lys Gly Val Gln  Trp Arg Trp 
    2615                 2620                 2625             


Asp Ala  Phe Leu Arg Thr Arg  Ala Gly Ile Glu Phe  Asn Gly Ile 
    2630                 2635                 2640             


Ser Arg  Arg Arg Tyr Leu Ala  Leu Leu Lys Asp Ile  Gln Ala Pro 
    2645                 2650                 2655             


Ile Thr  Leu Ile Tyr Gly Asp  Gln Ser Glu Phe Asn  Arg Pro Ala 
    2660                 2665                 2670             


Asp Leu  Gln Ala Ile Gln Ala  Ala Leu Pro Gln Ala  Gln Arg Leu 
    2675                 2680                 2685             


Thr Val  Ala Gly Gly His Asn  Leu His Phe Glu Asn  Pro Gln Ala 
    2690                 2695                 2700             


Ile Ala  Gln Ile Val Tyr Gln  Gln Leu Gln Thr Pro  Val Pro Lys 
    2705                 2710                 2715             


Thr Gln  
    2720 


<210> 19
<211> 8163
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
atggttggtc aatttgcaaa tttcgtcgat ctgctccagt acagagctaa acttcaggcg       60

cggaaaaccg tgtttagttt tctggctgat ggcgaagcgg aatctgcggc cctgacctac      120

ggagaattag accaaaaagc ccaggcgatc gccgcttttt tgcaagctaa ccaggctcaa      180

gggcaacggg cattattact ttatccaccg ggtttagagt ttatcggtgc ctttttggga      240

tgtttgtatg ctggtgttgt tgcggtgcca gcttacccac cacggccgaa taaatccttt      300

gaccgcctcc atagcattat ccaagatgcc caggcaaaat ttgccctcac cacaacagaa      360

cttaaagata aaattgccga tcgcctcgaa gctttagaag gtacggattt tcattgtttg      420

gctacagatc aagttgaatt aatttcagga aaaaattggc aaaaaccgaa catttccggc      480

acagatctcg cttttttgca atacaccagt ggctccacgg gcgatcctaa aggagtgatg      540

gtttcccacc acaatttgat ccacaactcc ggcttgatcc ggaatgcgct ggctatcgac      600

ttaaaagata ctcttttatc ttggatgccc ttaacccatg acatggggct catagcttgc      660

caccttgttc ctgccttagc cggaatcaat caaaatttaa tgccgacaga attatttatt      720

cgaagaccta ttctctggat gaaaaaagct catgaacata aagccagcat tctatcctca      780

cctaattttg gatacaatta ctttcttaaa tttctgaaag acaataaaag ttacgactgg      840

gatttatccc atatcagggt cattgcaaac ggggccgaac cgatccgcgc tgtgaccctc      900

gaaaattttg cgaaaacctt cgctacagca ggctttcaaa aatcagcatt ttatccctgt      960

tatggtatgg ctgaaaccac cctgatcgtt tccggtggta atggtcgtgc ccagcttccc     1020

caggaaatta tcgtcagcaa acagggcatc gaagcaaacc aagttcgccc tgcccaaggg     1080

acagaaacaa cggtgacctt ggtcggcagt ggtgaagtga ttggcgacca aattgtcaaa     1140

attgttgacc cccaggcttt aacagaatgt accgtcggtg aaattggcga agtatgggtt     1200

aagggcgaaa gtgttgccca gggctattgg caaaagccag acctcaccca gcaacaattc     1260

cagggaaacg tcggtgcaga aacgggcttt ttacgcacgg gcgatctggg ttttttgcaa     1320

ggtggcgaac tgtatattac gggtcgttta aaggatctcc tgattatccg ggggcgcaac     1380

cactatcccc aggacattga attaaccgtc gaagtggccc atcccgcttt acgacagggg     1440

gccggagccg ctgtatcagt agacgttaac ggggaagaac agttagtcat tgtccaggaa     1500

gttgagcgta aatatgcccg caaattaaat gtcgcggcag tagcccaagc tattcgtggg     1560

gcgatcgccg ccgaacatca actgcaaccc caggccattt gttttattaa acccggtagc     1620

attcccaaaa catccagcgg gaagattcgt cgccatgcct gcaaagctgg ttttctagac     1680

ggaagcttgg ctgtggttgg ggagtggcaa cccagccacc aaaaagaagg aaaaggaatt     1740

gggacacaag ccgttacccc ttctacgaca acatcaacga attttcccct gcctgaccag     1800

caccaacagc aaattgaagc ctggcttaag gataatattg cccatcgcct cggcattacg     1860

ccccaacaat tagacgaaac ggaacccttt gcaagttatg ggctggattc agtgcaagca     1920

gtacaggtca cagccgactt agaggattgg ctaggtcgaa aattagaccc cactctggcc     1980

tacgattatc cgaccattcg caccctggct cagtttttgg tccagggtaa tcaagcgcta     2040

gagaaaatac cacaggtgcc gaaaattcag ggcaaagaaa ttgccgtggt gggtctcagt     2100

tgtcgttttc cccaagctga caaccccgaa gctttttggg aattattacg taatggtaaa     2160

gatggagttc gcccccttaa aactcgctgg gccacgggag aatggggtgg ttttttagaa     2220

gatattgacc agtttgagcc gcaatttttt ggcatttccc cccgggaagc ggaacaaatg     2280

gatccccagc aacgcttact gttagaagta acctgggaag ccttggaacg ggcaaatatt     2340

ccggcagaaa gtttacgcca ttcccaaacg ggggtttttg tcggcattag taatagtgat     2400

tatgcccagt tgcaggtgcg ggaaaacaat ccgatcaatc cctacatggg gacgggcaac     2460

gcccacagta ttgctgcgaa tcgtctgtct tatttcctcg atctccgggg cgtttctctg     2520

agcatcgata cggcctgttc ctcttctctg gtggcggtac atctggcctg tcaaagttta     2580

atcaacggcg aatcggagtt ggcgatcgcc gccggggtga atttgatttt gacccccgat     2640

gtgacccaga cttttaccca ggcgggcatg atgagtaaga cgggccgttg ccagaccttt     2700

gatgccgagg ctgatggcta tgtgcggggc gaaggttgtg gggtcgttct cctcaaaccc     2760

ctggcccagg cagaacggga cggggataat attctcgcgg tgatccacgg ttcggcggtg     2820

aatcaagatg gacgcagtaa cggtttgacg gctcccaacg ggcgatcgca acaggccgtt     2880

attcgccaag ccctggccca agccggcatt accgccgccg atttagctta cctagaggcc     2940

cacggcaccg gcacgcccct gggtgatccc attgaaatta attccctgaa ggcggtttta     3000

caaacggcgc agcgggaaca gccctgtgtg gtgggttctg tgaaaacaaa cattggtcac     3060

ctcgaggcag cggcgggcat cgcgggctta atcaaggtga ttttgtccct agagcatgga     3120

atgattcccc aacatttgca ttttaagcag ctcaatcccc gcattgatct agacggttta     3180

gtgaccattg cgagcaaaga tcagccttgg tcaggcgggt cacaaaaacg gtttgctggg     3240

gtaagttcct ttgggtttgg tggcaccaat gcccacgtga ttgtcgggga ctatgctcaa     3300

caaaaatctc cccttgctcc tccggctacc caagaccgcc cttggcattt gctgaccctt     3360

tctgctaaaa atgcccaggc cttaaatgcc ctgcaaaaaa gctatggaga ctatctggcc     3420

caacatccca gcgttgaccc acgcgatctc tgtttgtctg ccaataccgg gcgatcgccc     3480

ctcaaagaac gtcgtttttt tgtctttaaa caagtcgccg atttacaaca aactctcaat     3540

caagattttc tggcccaacc acgcctcagt tcccccgcaa aaattgcctt tttgtttacg     3600

gggcaaggtt cccaatacta cggcatgggg caacaactgt accaaaccag cccagtattt     3660

cggcaagtgc tggatgagtg cgatcgcctc tggcagacct attcccccga agcccctgcc     3720

ctcaccgacc tgctgtacgg taaccataac cctgacctcg tccacgaaac tgtctatacc     3780

cagcccctcc tctttgctgt tgaatatgcg atcgcccaac tatggttaag ctggggcgtg     3840

acgccagact tttgcatggg ccatagcgtc ggcgaatatg tcgcggcttg tctggcgggg     3900

gtattttccc tggcagacgg catgaaatta attacggccc ggggcaaact gatgcacgcc     3960

ctacccagca atggcagtat ggcggcggtc tttgccgata aaacggtcat caaaccctac     4020

ctatcggagc atttgaccgt cggagccgaa aacggttccc atttggtgct atcaggaaag     4080

accccctgcc tcgaagccag tattcacaaa ctccaaagcc aagggatcaa aaccaaaccc     4140

ctcaaggttt cccatgcttt ccactcccct ttgatggctc ccatgctggc agagtttcgg     4200

gaaattgctg aacaaattac tttccacccg ccgcgtatcc cgctcatttc caatgtcacg     4260

ggcggccaga ttgaagcgga aattgcccag gccgactatt gggttaagca cgtttcgcaa     4320

cccgtcaaat ttgtccagag catccaaacc ctggcccaag cgggtgtcaa tgtttatctc     4380

gaaatcggcg taaaaccagt gctcctgagt atgggacgcc attgcttagc tgaacaagaa     4440

gcggtttggt tgcccagttt acgtccccat agtgagcctt ggccggaaat tttgaccagt     4500

ctcggcaaac tgtatgagca agggctaaac attgactggc agaccgtgga agctggcgat     4560

cgccgccgga aactgattct gcccacctat cccttccaac ggcaacgata ttggtttaat     4620

caaggctctt ggcaaactgt tgagaccgaa tctgtgaacc caggccctga cgatctcaat     4680

gattggttgt atcaggtggc gtggacgccc ctggacactt tgcccccggc ccctgaaccg     4740

tcggctaagc tgtggttaat cttgggcgat cgccatgatc accagcccat tgaagcccaa     4800

tttaaaaacg cccagcgggt gtatctcggc caaagcaatc attttccgac gaatgccccc     4860

tgggaagtat ctgccgatgc gttggataat ttatttactc acgtcggctc ccaaaattta     4920

gcaggcatcc tttacctgtg tcccccaggg gaagacccag aagacctaga tgaaattcaa     4980

aagcaaacca gtggcttcgc cctccaactg atccaaaccc tgtatcaaca aaagatcgcg     5040

gttccctgct ggtttgtgac ccaccagagc caacgggtgc ttgaaaccga tgctgtcacc     5100

ggatttgccc aagggggatt atggggactc gcccaggcga tcgccctcga acatccagag     5160

ttgtgggggg gaattattga tgtcgatgac agcctgccaa attttgccca gatttgccaa     5220

caaagacagg tgcagcagtt ggccgtgcgg caccaaaaac tctacggggc acagctcaaa     5280

aagcaaccgt cactgcccca gaaaaatctc cagattcaac cccaacagac ctatctagtg     5340

acagggggac tgggggccat tggccgtaaa attgcccaat ggctagccgc agcaggagca     5400

gaaaaagtaa ttctcgtcag ccggcgcgct ccggcagcgg atcagcagac gttaccgacc     5460

aatgcggtgg tttatccttg cgatttagcc gacgcagccc aggtggcaaa gctgtttcaa     5520

acctatcccc acatcaaagg aattttccat gcggcgggta ccttagctga tggtttgctg     5580

caacaacaaa cttggcaaaa gttccagacc gtcgccgccg ccaaaatgaa agggacatgg     5640

catctgcacc gccatagtca aaagctcgat ctggattttt ttgtgttgtt ttcctctgtg     5700

gcaggggtgc tcggttcacc gggacagggg aattatgccg ccgcaaaccg gggcatggcg     5760

gcgatcgccc aatatcgaca agcccaaggt ttacccgccc tggcgatcca ttgggggcct     5820

tgggccgaag ggggaatggc caactccctc agcaaccaaa atttagcgtg gctgccgccc     5880

ccccagggac taacaatcct cgaaaaagtc ttgggcgccc agggggaaat gggggtcttt     5940

aaaccggact ggcaaaacct ggccaaacag ttccccgaat ttgccaaaac ccattacttt     6000

gcagccgtta ttccctctgc tgaggctgtg cccccaacgg cttcaatttt tgacaaatta     6060

atcaacctag aagcttctca gcgggctgac tatctactgg attatctgcg gcggtctgtg     6120

gcgcaaatcc tcaagttaga aattgagcaa attcaaagcc acgatagcct gttggatctg     6180

ggcatggatt cgttgatgat catggaggcg atcgccagcc tcaagcagga tttacaactg     6240

atgttgtacc ccagggaaat ctacgaacgg cccagacttg atgtgttgac ggcctatcta     6300

gcggcggaat tcaccaaggc ccatgattct gaagcagcaa cggcggcagc agcgattccc     6360

tcccaaagcc tttcggtcaa aacaaaaaaa cagtggcaaa aacctgacca caaaaacccg     6420

aatcccattg cctttatcct ctctagcccc cggtcgggtt cgacgttgct gcgggtgatg     6480

ttagccggac atccggggtt atattcgccg ccagagctgc atttgctccc ctttgagact     6540

atgggcgatc gccaccagga attgggtcta tcccacctcg gcgaagggtt acaacgggcc     6600

ttaatggatc tagaaaacct caccccagag gcaagccagg cgaaggtcaa ccaatgggtc     6660

aaagcgaata cacccattgc agacatctat gcctatctcc aacggcaggc ggaacaacgt     6720

ttactcatcg acaaatctcc cagctacggc agcgatcgcc atattctaga ccacagcgaa     6780

atcctctttg accaggccaa atatatccat ctggtacgcc atccctacgc ggtgattgaa     6840

tcctttaccc gactgcggat ggataaactg ctgggggccg agcagcagaa cccctacgcc     6900

ctcgcggagt ccatttggcg caccagcaac cgcaatattt tagacctggg tcgcacggtt     6960

ggtgcggatc gatatctcca ggtgatttac gaagatctcg tccgtgaccc ccgcaaagtt     7020

ttgacaaata tttgtgattt cctgggggtg gactttgacg aagcgctcct caatccctac     7080

agcggcgatc gccttaccga tggcctccac caacagtcca tgggcgtcgg ggatcccaat     7140

ttcctccagc acaaaaccat tgatccggcc ctcgccgaca aatggcgctc aattaccctg     7200

cccgctgctc tccagctgga tacgatccag ttggccgaaa cgtttgctta cgatctcccc     7260

caggaacccc agctaacacc ccagacccaa tccttgccct cgatggtgga gcggttcgtg     7320

acagtgcgcg gtttagaaac ctgtctctgt gagtggggcg atcgccacca accattggtg     7380

ctacttctcc acggcatcct cgaacagggg gcctcctggc aactcatcgc gccccagttg     7440

gcggcccagg gctattgggt tgtggcccca gacctgcgtg gtcacggcaa atccgcccat     7500

gcccagtcct acagcatgct tgattttttg gctgacgtag atgcccttgc caaacaatta     7560

ggcgatcgcc cctttacctt ggtgggccac tccatgggtt ccatcatcgg tgccatgtat     7620

gcaggaattc gccaaaccca ggtagaaaag ttgatcctcg ttgaaaccat tgtccccaac     7680

gacatcgacg acgctgaaac cggtaatcac ctgacgaccc atctcgatta cctcgccgcg     7740

cccccccaac acccgatctt ccccagccta gaagtggccg cccgtcgcct ccgccaagcc     7800

acgccccaac tacccaaaga cctctcggcg ttcctcaccc agcgcagcac caaatccgtc     7860

gaaaaagggg tgcagtggcg ttgggatgct ttcctccgta cccgggcggg cattgaattc     7920

aatggcatta gcagacgacg ttacctggcc ctgctcaaag atatccaagc gccgatcacc     7980

ctcatctatg gcgatcagag tgaatttaac cgccctgctg atctccaggc gatccaagcg     8040

gctctccccc aggcccaacg tttaacggtt gctggcggcc ataacctcca ttttgagaat     8100

ccccaggcga tcgcccaaat tgtttatcaa caactccaga cccctgtacc caaaacacaa     8160

taa                                                                   8163


<210> 20
<211> 2720
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Val Gly Gln Phe Ala Asn Phe Val Asp Leu Leu Gln Tyr Arg Ala 
1               5                   10                  15      


Lys Leu Gln Ala Arg Lys Thr Val Phe Ser Phe Leu Ala Asp Gly Glu 
            20                  25                  30          


Ala Glu Ser Ala Ala Leu Thr Tyr Gly Glu Leu Asp Gln Lys Ala Gln 
        35                  40                  45              


Ala Ile Ala Ala Phe Leu Gln Ala Asn Gln Ala Gln Gly Gln Arg Ala 
    50                  55                  60                  


Leu Leu Leu Tyr Pro Pro Gly Leu Glu Phe Ile Gly Ala Phe Leu Gly 
65                  70                  75                  80  


Cys Leu Tyr Ala Gly Val Val Ala Val Pro Ala Tyr Pro Pro Arg Pro 
                85                  90                  95      


Asn Lys Ser Phe Asp Arg Leu His Ser Ile Ile Gln Asp Ala Gln Ala 
            100                 105                 110         


Lys Phe Ala Leu Thr Thr Thr Glu Leu Lys Asp Lys Ile Ala Asp Arg 
        115                 120                 125             


Leu Glu Ala Leu Glu Gly Thr Asp Phe His Cys Leu Ala Thr Asp Gln 
    130                 135                 140                 


Val Glu Leu Ile Ser Gly Lys Asn Trp Gln Lys Pro Asn Ile Ser Gly 
145                 150                 155                 160 


Thr Asp Leu Ala Phe Leu Gln Tyr Thr Ser Gly Ser Thr Gly Asp Pro 
                165                 170                 175     


Lys Gly Val Met Val Ser His His Asn Leu Ile His Asn Ser Gly Leu 
            180                 185                 190         


Ile Arg Asn Ala Leu Ala Ile Asp Leu Lys Asp Thr Leu Leu Ser Trp 
        195                 200                 205             


Met Pro Leu Thr His Asp Met Gly Leu Ile Ala Cys His Leu Val Pro 
    210                 215                 220                 


Ala Leu Ala Gly Ile Asn Gln Asn Leu Met Pro Thr Glu Leu Phe Ile 
225                 230                 235                 240 


Arg Arg Pro Ile Leu Trp Met Lys Lys Ala His Glu His Lys Ala Ser 
                245                 250                 255     


Ile Leu Ser Ser Pro Asn Phe Gly Tyr Asn Tyr Phe Leu Lys Phe Leu 
            260                 265                 270         


Lys Asp Asn Lys Ser Tyr Asp Trp Asp Leu Ser His Ile Arg Val Ile 
        275                 280                 285             


Ala Asn Gly Ala Glu Pro Ile Arg Ala Val Thr Leu Glu Asn Phe Ala 
    290                 295                 300                 


Lys Thr Phe Ala Thr Ala Gly Phe Gln Lys Ser Ala Phe Tyr Pro Cys 
305                 310                 315                 320 


Tyr Gly Met Ala Glu Thr Thr Leu Ile Val Ser Gly Gly Asn Gly Arg 
                325                 330                 335     


Ala Gln Leu Pro Gln Glu Ile Ile Val Ser Lys Gln Gly Ile Glu Ala 
            340                 345                 350         


Asn Gln Val Arg Pro Ala Gln Gly Thr Glu Thr Thr Val Thr Leu Val 
        355                 360                 365             


Gly Ser Gly Glu Val Ile Gly Asp Gln Ile Val Lys Ile Val Asp Pro 
    370                 375                 380                 


Gln Ala Leu Thr Glu Cys Thr Val Gly Glu Ile Gly Glu Val Trp Val 
385                 390                 395                 400 


Lys Gly Glu Ser Val Ala Gln Gly Tyr Trp Gln Lys Pro Asp Leu Thr 
                405                 410                 415     


Gln Gln Gln Phe Gln Gly Asn Val Gly Ala Glu Thr Gly Phe Leu Arg 
            420                 425                 430         


Thr Gly Asp Leu Gly Phe Leu Gln Gly Gly Glu Leu Tyr Ile Thr Gly 
        435                 440                 445             


Arg Leu Lys Asp Leu Leu Ile Ile Arg Gly Arg Asn His Tyr Pro Gln 
    450                 455                 460                 


Asp Ile Glu Leu Thr Val Glu Val Ala His Pro Ala Leu Arg Gln Gly 
465                 470                 475                 480 


Ala Gly Ala Ala Val Ser Val Asp Val Asn Gly Glu Glu Gln Leu Val 
                485                 490                 495     


Ile Val Gln Glu Val Glu Arg Lys Tyr Ala Arg Lys Leu Asn Val Ala 
            500                 505                 510         


Ala Val Ala Gln Ala Ile Arg Gly Ala Ile Ala Ala Glu His Gln Leu 
        515                 520                 525             


Gln Pro Gln Ala Ile Cys Phe Ile Lys Pro Gly Ser Ile Pro Lys Thr 
    530                 535                 540                 


Ser Ser Gly Lys Ile Arg Arg His Ala Cys Lys Ala Gly Phe Leu Asp 
545                 550                 555                 560 


Gly Ser Leu Ala Val Val Gly Glu Trp Gln Pro Ser His Gln Lys Glu 
                565                 570                 575     


Gly Lys Gly Ile Gly Thr Gln Ala Val Thr Pro Ser Thr Thr Thr Ser 
            580                 585                 590         


Thr Asn Phe Pro Leu Pro Asp Gln His Gln Gln Gln Ile Glu Ala Trp 
        595                 600                 605             


Leu Lys Asp Asn Ile Ala His Arg Leu Gly Ile Thr Pro Gln Gln Leu 
    610                 615                 620                 


Asp Glu Thr Glu Pro Phe Ala Ser Tyr Gly Leu Asp Ser Val Gln Ala 
625                 630                 635                 640 


Val Gln Val Thr Ala Asp Leu Glu Asp Trp Leu Gly Arg Lys Leu Asp 
                645                 650                 655     


Pro Thr Leu Ala Tyr Asp Tyr Pro Thr Ile Arg Thr Leu Ala Gln Phe 
            660                 665                 670         


Leu Val Gln Gly Asn Gln Ala Leu Glu Lys Ile Pro Gln Val Pro Lys 
        675                 680                 685             


Ile Gln Gly Lys Glu Ile Ala Val Val Gly Leu Ser Cys Arg Phe Pro 
    690                 695                 700                 


Gln Ala Asp Asn Pro Glu Ala Phe Trp Glu Leu Leu Arg Asn Gly Lys 
705                 710                 715                 720 


Asp Gly Val Arg Pro Leu Lys Thr Arg Trp Ala Thr Gly Glu Trp Gly 
                725                 730                 735     


Gly Phe Leu Glu Asp Ile Asp Gln Phe Glu Pro Gln Phe Phe Gly Ile 
            740                 745                 750         


Ser Pro Arg Glu Ala Glu Gln Met Asp Pro Gln Gln Arg Leu Leu Leu 
        755                 760                 765             


Glu Val Thr Trp Glu Ala Leu Glu Arg Ala Asn Ile Pro Ala Glu Ser 
    770                 775                 780                 


Leu Arg His Ser Gln Thr Gly Val Phe Val Gly Ile Ser Asn Ser Asp 
785                 790                 795                 800 


Tyr Ala Gln Leu Gln Val Arg Glu Asn Asn Pro Ile Asn Pro Tyr Met 
                805                 810                 815     


Gly Thr Gly Asn Ala His Ser Ile Ala Ala Asn Arg Leu Ser Tyr Phe 
            820                 825                 830         


Leu Asp Leu Arg Gly Val Ser Leu Ser Ile Asp Thr Ala Cys Ser Ser 
        835                 840                 845             


Ser Leu Val Ala Val His Leu Ala Cys Gln Ser Leu Ile Asn Gly Glu 
    850                 855                 860                 


Ser Glu Leu Ala Ile Ala Ala Gly Val Asn Leu Ile Leu Thr Pro Asp 
865                 870                 875                 880 


Val Thr Gln Thr Phe Thr Gln Ala Gly Met Met Ser Lys Thr Gly Arg 
                885                 890                 895     


Cys Gln Thr Phe Asp Ala Glu Ala Asp Gly Tyr Val Arg Gly Glu Gly 
            900                 905                 910         


Cys Gly Val Val Leu Leu Lys Pro Leu Ala Gln Ala Glu Arg Asp Gly 
        915                 920                 925             


Asp Asn Ile Leu Ala Val Ile His Gly Ser Ala Val Asn Gln Asp Gly 
    930                 935                 940                 


Arg Ser Asn Gly Leu Thr Ala Pro Asn Gly Arg Ser Gln Gln Ala Val 
945                 950                 955                 960 


Ile Arg Gln Ala Leu Ala Gln Ala Gly Ile Thr Ala Ala Asp Leu Ala 
                965                 970                 975     


Tyr Leu Glu Ala His Gly Thr Gly Thr Pro Leu Gly Asp Pro Ile Glu 
            980                 985                 990         


Ile Asn Ser Leu Lys Ala Val Leu  Gln Thr Ala Gln Arg  Glu Gln Pro 
        995                 1000                 1005             


Cys Val  Val Gly Ser Val Lys  Thr Asn Ile Gly His  Leu Glu Ala 
    1010                 1015                 1020             


Ala Ala  Gly Ile Ala Gly Leu  Ile Lys Val Ile Leu  Ser Leu Glu 
    1025                 1030                 1035             


His Gly  Met Ile Pro Gln His  Leu His Phe Lys Gln  Leu Asn Pro 
    1040                 1045                 1050             


Arg Ile  Asp Leu Asp Gly Leu  Val Thr Ile Ala Ser  Lys Asp Gln 
    1055                 1060                 1065             


Pro Trp  Ser Gly Gly Ser Gln  Lys Arg Phe Ala Gly  Val Ser Ser 
    1070                 1075                 1080             


Phe Gly  Phe Gly Gly Thr Asn  Ala His Val Ile Val  Gly Asp Tyr 
    1085                 1090                 1095             


Ala Gln  Gln Lys Ser Pro Leu  Ala Pro Pro Ala Thr  Gln Asp Arg 
    1100                 1105                 1110             


Pro Trp  His Leu Leu Thr Leu  Ser Ala Lys Asn Ala  Gln Ala Leu 
    1115                 1120                 1125             


Asn Ala  Leu Gln Lys Ser Tyr  Gly Asp Tyr Leu Ala  Gln His Pro 
    1130                 1135                 1140             


Ser Val  Asp Pro Arg Asp Leu  Cys Leu Ser Ala Asn  Thr Gly Arg 
    1145                 1150                 1155             


Ser Pro  Leu Lys Glu Arg Arg  Phe Phe Val Phe Lys  Gln Val Ala 
    1160                 1165                 1170             


Asp Leu  Gln Gln Thr Leu Asn  Gln Asp Phe Leu Ala  Gln Pro Arg 
    1175                 1180                 1185             


Leu Ser  Ser Pro Ala Lys Ile  Ala Phe Leu Phe Thr  Gly Gln Gly 
    1190                 1195                 1200             


Ser Gln  Tyr Tyr Gly Met Gly  Gln Gln Leu Tyr Gln  Thr Ser Pro 
    1205                 1210                 1215             


Val Phe  Arg Gln Val Leu Asp  Glu Cys Asp Arg Leu  Trp Gln Thr 
    1220                 1225                 1230             


Tyr Ser  Pro Glu Ala Pro Ala  Leu Thr Asp Leu Leu  Tyr Gly Asn 
    1235                 1240                 1245             


His Asn  Pro Asp Leu Val His  Glu Thr Val Tyr Thr  Gln Pro Leu 
    1250                 1255                 1260             


Leu Phe  Ala Val Glu Tyr Ala  Ile Ala Gln Leu Trp  Leu Ser Trp 
    1265                 1270                 1275             


Gly Val  Thr Pro Asp Phe Cys  Met Gly His Ser Val  Gly Glu Tyr 
    1280                 1285                 1290             


Val Ala  Ala Cys Leu Ala Gly  Val Phe Ser Leu Ala  Asp Gly Met 
    1295                 1300                 1305             


Lys Leu  Ile Thr Ala Arg Gly  Lys Leu Met His Ala  Leu Pro Ser 
    1310                 1315                 1320             


Asn Gly  Ser Met Ala Ala Val  Phe Ala Asp Lys Thr  Val Ile Lys 
    1325                 1330                 1335             


Pro Tyr  Leu Ser Glu His Leu  Thr Val Gly Ala Glu  Asn Gly Ser 
    1340                 1345                 1350             


His Leu  Val Leu Ser Gly Lys  Thr Pro Cys Leu Glu  Ala Ser Ile 
    1355                 1360                 1365             


His Lys  Leu Gln Ser Gln Gly  Ile Lys Thr Lys Pro  Leu Lys Val 
    1370                 1375                 1380             


Ser His  Ala Phe His Ser Pro  Leu Met Ala Pro Met  Leu Ala Glu 
    1385                 1390                 1395             


Phe Arg  Glu Ile Ala Glu Gln  Ile Thr Phe His Pro  Pro Arg Ile 
    1400                 1405                 1410             


Pro Leu  Ile Ser Asn Val Thr  Gly Gly Gln Ile Glu  Ala Glu Ile 
    1415                 1420                 1425             


Ala Gln  Ala Asp Tyr Trp Val  Lys His Val Ser Gln  Pro Val Lys 
    1430                 1435                 1440             


Phe Val  Gln Ser Ile Gln Thr  Leu Ala Gln Ala Gly  Val Asn Val 
    1445                 1450                 1455             


Tyr Leu  Glu Ile Gly Val Lys  Pro Val Leu Leu Ser  Met Gly Arg 
    1460                 1465                 1470             


His Cys  Leu Ala Glu Gln Glu  Ala Val Trp Leu Pro  Ser Leu Arg 
    1475                 1480                 1485             


Pro His  Ser Glu Pro Trp Pro  Glu Ile Leu Thr Ser  Leu Gly Lys 
    1490                 1495                 1500             


Leu Tyr  Glu Gln Gly Leu Asn  Ile Asp Trp Gln Thr  Val Glu Ala 
    1505                 1510                 1515             


Gly Asp  Arg Arg Arg Lys Leu  Ile Leu Pro Thr Tyr  Pro Phe Gln 
    1520                 1525                 1530             


Arg Gln  Arg Tyr Trp Phe Asn  Gln Gly Ser Trp Gln  Thr Val Glu 
    1535                 1540                 1545             


Thr Glu  Ser Val Asn Pro Gly  Pro Asp Asp Leu Asn  Asp Trp Leu 
    1550                 1555                 1560             


Tyr Gln  Val Ala Trp Thr Pro  Leu Asp Thr Leu Pro  Pro Ala Pro 
    1565                 1570                 1575             


Glu Pro  Ser Ala Lys Leu Trp  Leu Ile Leu Gly Asp  Arg His Asp 
    1580                 1585                 1590             


His Gln  Pro Ile Glu Ala Gln  Phe Lys Asn Ala Gln  Arg Val Tyr 
    1595                 1600                 1605             


Leu Gly  Gln Ser Asn His Phe  Pro Thr Asn Ala Pro  Trp Glu Val 
    1610                 1615                 1620             


Ser Ala  Asp Ala Leu Asp Asn  Leu Phe Thr His Val  Gly Ser Gln 
    1625                 1630                 1635             


Asn Leu  Ala Gly Ile Leu Tyr  Leu Cys Pro Pro Gly  Glu Asp Pro 
    1640                 1645                 1650             


Glu Asp  Leu Asp Glu Ile Gln  Lys Gln Thr Ser Gly  Phe Ala Leu 
    1655                 1660                 1665             


Gln Leu  Ile Gln Thr Leu Tyr  Gln Gln Lys Ile Ala  Val Pro Cys 
    1670                 1675                 1680             


Trp Phe  Val Thr His Gln Ser  Gln Arg Val Leu Glu  Thr Asp Ala 
    1685                 1690                 1695             


Val Thr  Gly Phe Ala Gln Gly  Gly Leu Trp Gly Leu  Ala Gln Ala 
    1700                 1705                 1710             


Ile Ala  Leu Glu His Pro Glu  Leu Trp Gly Gly Ile  Ile Asp Val 
    1715                 1720                 1725             


Asp Asp  Ser Leu Pro Asn Phe  Ala Gln Ile Cys Gln  Gln Arg Gln 
    1730                 1735                 1740             


Val Gln  Gln Leu Ala Val Arg  His Gln Lys Leu Tyr  Gly Ala Gln 
    1745                 1750                 1755             


Leu Lys  Lys Gln Pro Ser Leu  Pro Gln Lys Asn Leu  Gln Ile Gln 
    1760                 1765                 1770             


Pro Gln  Gln Thr Tyr Leu Val  Thr Gly Gly Leu Gly  Ala Ile Gly 
    1775                 1780                 1785             


Arg Lys  Ile Ala Gln Trp Leu  Ala Ala Ala Gly Ala  Glu Lys Val 
    1790                 1795                 1800             


Ile Leu  Val Ser Arg Arg Ala  Pro Ala Ala Asp Gln  Gln Thr Leu 
    1805                 1810                 1815             


Pro Thr  Asn Ala Val Val Tyr  Pro Cys Asp Leu Ala  Asp Ala Ala 
    1820                 1825                 1830             


Gln Val  Ala Lys Leu Phe Gln  Thr Tyr Pro His Ile  Lys Gly Ile 
    1835                 1840                 1845             


Phe His  Ala Ala Gly Thr Leu  Ala Asp Gly Leu Leu  Gln Gln Gln 
    1850                 1855                 1860             


Thr Trp  Gln Lys Phe Gln Thr  Val Ala Ala Ala Lys  Met Lys Gly 
    1865                 1870                 1875             


Thr Trp  His Leu His Arg His  Ser Gln Lys Leu Asp  Leu Asp Phe 
    1880                 1885                 1890             


Phe Val  Leu Phe Ser Ser Val  Ala Gly Val Leu Gly  Ser Pro Gly 
    1895                 1900                 1905             


Gln Gly  Asn Tyr Ala Ala Ala  Asn Arg Gly Met Ala  Ala Ile Ala 
    1910                 1915                 1920             


Gln Tyr  Arg Gln Ala Gln Gly  Leu Pro Ala Leu Ala  Ile His Trp 
    1925                 1930                 1935             


Gly Pro  Trp Ala Glu Gly Gly  Met Ala Asn Ser Leu  Ser Asn Gln 
    1940                 1945                 1950             


Asn Leu  Ala Trp Leu Pro Pro  Pro Gln Gly Leu Thr  Ile Leu Glu 
    1955                 1960                 1965             


Lys Val  Leu Gly Ala Gln Gly  Glu Met Gly Val Phe  Lys Pro Asp 
    1970                 1975                 1980             


Trp Gln  Asn Leu Ala Lys Gln  Phe Pro Glu Phe Ala  Lys Thr His 
    1985                 1990                 1995             


Tyr Phe  Ala Ala Val Ile Pro  Ser Ala Glu Ala Val  Pro Pro Thr 
    2000                 2005                 2010             


Ala Ser  Ile Phe Asp Lys Leu  Ile Asn Leu Glu Ala  Ser Gln Arg 
    2015                 2020                 2025             


Ala Asp  Tyr Leu Leu Asp Tyr  Leu Arg Arg Ser Val  Ala Gln Ile 
    2030                 2035                 2040             


Leu Lys  Leu Glu Ile Glu Gln  Ile Gln Ser His Asp  Ser Leu Leu 
    2045                 2050                 2055             


Asp Leu  Gly Met Asp Ser Leu  Met Ile Met Glu Ala  Ile Ala Ser 
    2060                 2065                 2070             


Leu Lys  Gln Asp Leu Gln Leu  Met Leu Tyr Pro Arg  Glu Ile Tyr 
    2075                 2080                 2085             


Glu Arg  Pro Arg Leu Asp Val  Leu Thr Ala Tyr Leu  Ala Ala Glu 
    2090                 2095                 2100             


Phe Thr  Lys Ala His Asp Ser  Glu Ala Ala Thr Ala  Ala Ala Ala 
    2105                 2110                 2115             


Ile Pro  Ser Gln Ser Leu Ser  Val Lys Thr Lys Lys  Gln Trp Gln 
    2120                 2125                 2130             


Lys Pro  Asp His Lys Asn Pro  Asn Pro Ile Ala Phe  Ile Leu Ser 
    2135                 2140                 2145             


Ser Pro  Arg Ser Gly Ser Thr  Leu Leu Arg Val Met  Leu Ala Gly 
    2150                 2155                 2160             


His Pro  Gly Leu Tyr Ser Pro  Pro Glu Leu His Leu  Leu Pro Phe 
    2165                 2170                 2175             


Glu Thr  Met Gly Asp Arg His  Gln Glu Leu Gly Leu  Ser His Leu 
    2180                 2185                 2190             


Gly Glu  Gly Leu Gln Arg Ala  Leu Met Asp Leu Glu  Asn Leu Thr 
    2195                 2200                 2205             


Pro Glu  Ala Ser Gln Ala Lys  Val Asn Gln Trp Val  Lys Ala Asn 
    2210                 2215                 2220             


Thr Pro  Ile Ala Asp Ile Tyr  Ala Tyr Leu Gln Arg  Gln Ala Glu 
    2225                 2230                 2235             


Gln Arg  Leu Leu Ile Asp Lys  Ser Pro Ser Tyr Gly  Ser Asp Arg 
    2240                 2245                 2250             


His Ile  Leu Asp His Ser Glu  Ile Leu Phe Asp Gln  Ala Lys Tyr 
    2255                 2260                 2265             


Ile His  Leu Val Arg His Pro  Tyr Ala Val Ile Glu  Ser Phe Thr 
    2270                 2275                 2280             


Arg Leu  Arg Met Asp Lys Leu  Leu Gly Ala Glu Gln  Gln Asn Pro 
    2285                 2290                 2295             


Tyr Ala  Leu Ala Glu Ser Ile  Trp Arg Thr Ser Asn  Arg Asn Ile 
    2300                 2305                 2310             


Leu Asp  Leu Gly Arg Thr Val  Gly Ala Asp Arg Tyr  Leu Gln Val 
    2315                 2320                 2325             


Ile Tyr  Glu Asp Leu Val Arg  Asp Pro Arg Lys Val  Leu Thr Asn 
    2330                 2335                 2340             


Ile Cys  Asp Phe Leu Gly Val  Asp Phe Asp Glu Ala  Leu Leu Asn 
    2345                 2350                 2355             


Pro Tyr  Ser Gly Asp Arg Leu  Thr Asp Gly Leu His  Gln Gln Ser 
    2360                 2365                 2370             


Met Gly  Val Gly Asp Pro Asn  Phe Leu Gln His Lys  Thr Ile Asp 
    2375                 2380                 2385             


Pro Ala  Leu Ala Asp Lys Trp  Arg Ser Ile Thr Leu  Pro Ala Ala 
    2390                 2395                 2400             


Leu Gln  Leu Asp Thr Ile Gln  Leu Ala Glu Thr Phe  Ala Tyr Asp 
    2405                 2410                 2415             


Leu Pro  Gln Glu Pro Gln Leu  Thr Pro Gln Thr Gln  Ser Leu Pro 
    2420                 2425                 2430             


Ser Met  Val Glu Arg Phe Val  Thr Val Arg Gly Leu  Glu Thr Cys 
    2435                 2440                 2445             


Leu Cys  Glu Trp Gly Asp Arg  His Gln Pro Leu Val  Leu Leu Leu 
    2450                 2455                 2460             


His Gly  Ile Leu Glu Gln Gly  Ala Ser Trp Gln Leu  Ile Ala Pro 
    2465                 2470                 2475             


Gln Leu  Ala Ala Gln Gly Tyr  Trp Val Val Ala Pro  Asp Leu Arg 
    2480                 2485                 2490             


Gly His  Gly Lys Ser Ala His  Ala Gln Ser Tyr Ser  Met Leu Asp 
    2495                 2500                 2505             


Phe Leu  Ala Asp Val Asp Ala  Leu Ala Lys Gln Leu  Gly Asp Arg 
    2510                 2515                 2520             


Pro Phe  Thr Leu Val Gly His  Ser Met Gly Ser Ile  Ile Gly Ala 
    2525                 2530                 2535             


Met Tyr  Ala Gly Ile Arg Gln  Thr Gln Val Glu Lys  Leu Ile Leu 
    2540                 2545                 2550             


Val Glu  Thr Ile Val Pro Asn  Asp Ile Asp Asp Ala  Glu Thr Gly 
    2555                 2560                 2565             


Asn His  Leu Thr Thr His Leu  Asp Tyr Leu Ala Ala  Pro Pro Gln 
    2570                 2575                 2580             


His Pro  Ile Phe Pro Ser Leu  Glu Val Ala Ala Arg  Arg Leu Arg 
    2585                 2590                 2595             


Gln Ala  Thr Pro Gln Leu Pro  Lys Asp Leu Ser Ala  Phe Leu Thr 
    2600                 2605                 2610             


Gln Arg  Ser Thr Lys Ser Val  Glu Lys Gly Val Gln  Trp Arg Trp 
    2615                 2620                 2625             


Asp Ala  Phe Leu Arg Thr Arg  Ala Gly Ile Glu Phe  Asn Gly Ile 
    2630                 2635                 2640             


Ser Arg  Arg Arg Tyr Leu Ala  Leu Leu Lys Asp Ile  Gln Ala Pro 
    2645                 2650                 2655             


Ile Thr  Leu Ile Tyr Gly Asp  Gln Ser Glu Phe Asn  Arg Pro Ala 
    2660                 2665                 2670             


Asp Leu  Gln Ala Ile Gln Ala  Ala Leu Pro Gln Ala  Gln Arg Leu 
    2675                 2680                 2685             


Thr Val  Ala Gly Gly His Asn  Leu His Phe Glu Asn  Pro Gln Ala 
    2690                 2695                 2700             


Ile Ala  Gln Ile Val Tyr Gln  Gln Leu Gln Thr Pro  Val Pro Lys 
    2705                 2710                 2715             


Thr Gln  
    2720 


<210> 21
<211> 8163
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
atggttggtc aatttgcaaa tttcgtcgat ctgctccagt acagagctaa acttcaggcg       60

cggaaaaccg tgtttagttt tctggctgat ggcgaagcgg aatctgcggc cctgacctac      120

ggagaattag accaaaaagc ccaggcgatc gccgcttttt tgcaagctaa ccaggctcaa      180

gggcaacggg cattattact ttatccaccg ggtttagagt ttatcggtgc ctttttggga      240

tgtttgtatg ctggtgttgt tgcggtgcca gcttacccac cacggccgaa taaatccttt      300

gaccgcctcc atagcattat ccaagatgcc caggcaaaat ttgccctcac cacaacagaa      360

cttaaagata aaattgccga tcgcctcgaa gctttagaag gtacggattt tcattgtttg      420

gctacagatc aagttgaatt aatttcagga aaaaattggc aaaaaccgaa catttccggc      480

acagatctcg cttttttgca atacaccagt ggctccacgg gcgatcctaa aggagtgatg      540

gtttcccacc acaatttgat ccacaactcc ggcttgctcg ccgaggcctg cgagctgacc      600

gccgccactc ccatgggcgg ctggctgccc atgtaccacg acatggggct cctgggcacg      660

ctgacaccgg ccctgtacct cggcaccacg tgcgtgctga tgagctccac ggcattcatc      720

aaacggccgc acctgtggct acggaccatc gaccggttcg gcctggtctg gtcgtcggct      780

cccgacttcg cgtacgacat gtgtctgaag cgcgtcaccg acgagcagat cgccgggctg      840

gacctgtccc gctggcggtg ggccggcaac ggggccgaac cgatccgcgc tgtgaccctc      900

gaaaattttg cgaaaacctt cgctacagca ggctttcaaa aatcagcatt ttatccctgt      960

tatggtatgg ctgaaaccac cctgatcgtt tccggtggta atggtcgtgc ccagcttccc     1020

caggaaatta tcgtcagcaa acagggcatc gaagcaaacc aagttcgccc tgcccaaggg     1080

acagaaacaa cggtgacctt ggtcggcagt ggtgaagtga ttggcgacca aattgtcaaa     1140

attgttgacc cccaggcttt aacagaatgt accgtcggtg aaattggcga agtatgggtt     1200

aagggcgaaa gtgttgccca gggctattgg caaaagccag acctcaccca gcaacaattc     1260

cagggaaacg tcggtgcaga aacgggcttt ttacgcacgg gcgatctggg ttttttgcaa     1320

ggtggcgaac tgtatattac gggtcgttta aaggatctcc tgattatccg ggggcgcaac     1380

cactatcccc aggacattga attaaccgtc gaagtggccc atcccgcttt acgacagggg     1440

gccggagccg ctgtatcagt agacgttaac ggggaagaac agttagtcat tgtccaggaa     1500

gttgagcgta aatatgcccg caaattaaat gtcgcggcag tagcccaagc tattcgtggg     1560

gcgatcgccg ccgaacatca actgcaaccc caggccattt gttttattaa acccggtagc     1620

attcccaaaa catccagcgg gaagattcgt cgccatgcct gcaaagctgg ttttctagac     1680

ggaagcttgg ctgtggttgg ggagtggcaa cccagccacc aaaaagaagg aaaaggaatt     1740

gggacacaag ccgttacccc ttctacgaca acatcaacga attttcccct gcctgaccag     1800

caccaacagc aaattgaagc ctggcttaag gataatattg cccatcgcct cggcattacg     1860

ccccaacaat tagacgaaac ggaacccttt gcaagttatg ggctggattc agtgcaagca     1920

gtacaggtca cagccgactt agaggattgg ctaggtcgaa aattagaccc cactctggcc     1980

tacgattatc cgaccattcg caccctggct cagtttttgg tccagggtaa tcaagcgcta     2040

gagaaaatac cacaggtgcc gaaaattcag ggcaaagaaa ttgccgtggt gggtctcagt     2100

tgtcgttttc cccaagctga caaccccgaa gctttttggg aattattacg taatggtaaa     2160

gatggagttc gcccccttaa aactcgctgg gccacgggag aatggggtgg ttttttagaa     2220

gatattgacc agtttgagcc gcaatttttt ggcatttccc cccgggaagc ggaacaaatg     2280

gatccccagc aacgcttact gttagaagta acctgggaag ccttggaacg ggcaaatatt     2340

ccggcagaaa gtttacgcca ttcccaaacg ggggtttttg tcggcattag taatagtgat     2400

tatgcccagt tgcaggtgcg ggaaaacaat ccgatcaatc cctacatggg gacgggcaac     2460

gcccacagta ttgctgcgaa tcgtctgtct tatttcctcg atctccgggg cgtttctctg     2520

agcatcgata cggcctgttc ctcttctctg gtggcggtac atctggcctg tcaaagttta     2580

atcaacggcg aatcggagtt ggcgatcgcc gccggggtga atttgatttt gacccccgat     2640

gtgacccaga cttttaccca ggcgggcatg atgagtaaga cgggccgttg ccagaccttt     2700

gatgccgagg ctgatggcta tgtgcggggc gaaggttgtg gggtcgttct cctcaaaccc     2760

ctggcccagg cagaacggga cggggataat attctcgcgg tgatccacgg ttcggcggtg     2820

aatcaagatg gacgcagtaa cggtttgacg gctcccaacg ggcgatcgca acaggccgtt     2880

attcgccaag ccctggccca agccggcatt accgccgccg atttagctta cctagaggcc     2940

cacggcaccg gcacgcccct gggtgatccc attgaaatta attccctgaa ggcggtttta     3000

caaacggcgc agcgggaaca gccctgtgtg gtgggttctg tgaaaacaaa cattggtcac     3060

ctcgaggcag cggcgggcat cgcgggctta atcaaggtga ttttgtccct agagcatgga     3120

atgattcccc aacatttgca ttttaagcag ctcaatcccc gcattgatct agacggttta     3180

gtgaccattg cgagcaaaga tcagccttgg tcaggcgggt cacaaaaacg gtttgctggg     3240

gtaagttcct ttgggtttgg tggcaccaat gcccacgtga ttgtcgggga ctatgctcaa     3300

caaaaatctc cccttgctcc tccggctacc caagaccgcc cttggcattt gctgaccctt     3360

tctgctaaaa atgcccaggc cttaaatgcc ctgcaaaaaa gctatggaga ctatctggcc     3420

caacatccca gcgttgaccc acgcgatctc tgtttgtctg ccaataccgg gcgatcgccc     3480

ctcaaagaac gtcgtttttt tgtctttaaa caagtcgccg atttacaaca aactctcaat     3540

caagattttc tggcccaacc acgcctcagt tcccccgcaa aaattgcctt tttgtttacg     3600

gggcaaggtt cccaatacta cggcatgggg caacaactgt accaaaccag cccagtattt     3660

cggcaagtgc tggatgagtg cgatcgcctc tggcagacct attcccccga agcccctgcc     3720

ctcaccgacc tgctgtacgg taaccataac cctgacctcg tccacgaaac tgtctatacc     3780

cagcccctcc tctttgctgt tgaatatgcg atcgcccaac tatggttaag ctggggcgtg     3840

acgccagact tttgcatggg ccatagcgtc ggcgaatatg tcgcggcttg tctggcgggg     3900

gtattttccc tggcagacgg catgaaatta attacggccc ggggcaaact gatgcacgcc     3960

ctacccagca atggcagtat ggcggcggtc tttgccgata aaacggtcat caaaccctac     4020

ctatcggagc atttgaccgt cggagccgaa aacggttccc atttggtgct atcaggaaag     4080

accccctgcc tcgaagccag tattcacaaa ctccaaagcc aagggatcaa aaccaaaccc     4140

ctcaaggttt cccatgcttt ccactcccct ttgatggctc ccatgctggc agagtttcgg     4200

gaaattgctg aacaaattac tttccacccg ccgcgtatcc cgctcatttc caatgtcacg     4260

ggcggccaga ttgaagcgga aattgcccag gccgactatt gggttaagca cgtttcgcaa     4320

cccgtcaaat ttgtccagag catccaaacc ctggcccaag cgggtgtcaa tgtttatctc     4380

gaaatcggcg taaaaccagt gctcctgagt atgggacgcc attgcttagc tgaacaagaa     4440

gcggtttggt tgcccagttt acgtccccat agtgagcctt ggccggaaat tttgaccagt     4500

ctcggcaaac tgtatgagca agggctaaac attgactggc agaccgtgga agctggcgat     4560

cgccgccgga aactgattct gcccacctat cccttccaac ggcaacgata ttggtttaat     4620

caaggctctt ggcaaactgt tgagaccgaa tctgtgaacc caggccctga cgatctcaat     4680

gattggttgt atcaggtggc gtggacgccc ctggacactt tgcccccggc ccctgaaccg     4740

tcggctaagc tgtggttaat cttgggcgat cgccatgatc accagcccat tgaagcccaa     4800

tttaaaaacg cccagcgggt gtatctcggc caaagcaatc attttccgac gaatgccccc     4860

tgggaagtat ctgccgatgc gttggataat ttatttactc acgtcggctc ccaaaattta     4920

gcaggcatcc tttacctgtg tcccccaggg gaagacccag aagacctaga tgaaattcaa     4980

aagcaaacca gtggcttcgc cctccaactg atccaaaccc tgtatcaaca aaagatcgcg     5040

gttccctgct ggtttgtgac ccaccagagc caacgggtgc ttgaaaccga tgctgtcacc     5100

ggatttgccc aagggggatt atggggactc gcccaggcga tcgccctcga acatccagag     5160

ttgtgggggg gaattattga tgtcgatgac agcctgccaa attttgccca gatttgccaa     5220

caaagacagg tgcagcagtt ggccgtgcgg caccaaaaac tctacggggc acagctcaaa     5280

aagcaaccgt cactgcccca gaaaaatctc cagattcaac cccaacagac ctatctagtg     5340

acagggggac tgggggccat tggccgtaaa attgcccaat ggctagccgc agcaggagca     5400

gaaaaagtaa ttctcgtcag ccggcgcgct ccggcagcgg atcagcagac gttaccgacc     5460

aatgcggtgg tttatccttg cgatttagcc gacgcagccc aggtggcaaa gctgtttcaa     5520

acctatcccc acatcaaagg aattttccat gcggcgggta ccttagctga tggtttgctg     5580

caacaacaaa cttggcaaaa gttccagacc gtcgccgccg ccaaaatgaa agggacatgg     5640

catctgcacc gccatagtca aaagctcgat ctggattttt ttgtgttgtt ttcctctgtg     5700

gcaggggtgc tcggttcacc gggacagggg aattatgccg ccgcaaaccg gggcatggcg     5760

gcgatcgccc aatatcgaca agcccaaggt ttacccgccc tggcgatcca ttgggggcct     5820

tgggccgaag ggggaatggc caactccctc agcaaccaaa atttagcgtg gctgccgccc     5880

ccccagggac taacaatcct cgaaaaagtc ttgggcgccc agggggaaat gggggtcttt     5940

aaaccggact ggcaaaacct ggccaaacag ttccccgaat ttgccaaaac ccattacttt     6000

gcagccgtta ttccctctgc tgaggctgtg cccccaacgg cttcaatttt tgacaaatta     6060

atcaacctag aagcttctca gcgggctgac tatctactgg attatctgcg gcggtctgtg     6120

gcgcaaatcc tcaagttaga aattgagcaa attcaaagcc acgatagcct gttggatctg     6180

ggcatggatt cgttgatgat catggaggcg atcgccagcc tcaagcagga tttacaactg     6240

atgttgtacc ccagggaaat ctacgaacgg cccagacttg atgtgttgac ggcctatcta     6300

gcggcggaat tcaccaaggc ccatgattct gaagcagcaa cggcggcagc agcgattccc     6360

tcccaaagcc tttcggtcaa aacaaaaaaa cagtggcaaa aacctgacca caaaaacccg     6420

aatcccattg cctttatcct ctctagcccc cggtcgggtt cgacgttgct gcgggtgatg     6480

ttagccggac atccggggtt atattcgccg ccagagctgc atttgctccc ctttgagact     6540

atgggcgatc gccaccagga attgggtcta tcccacctcg gcgaagggtt acaacgggcc     6600

ttaatggatc tagaaaacct caccccagag gcaagccagg cgaaggtcaa ccaatgggtc     6660

aaagcgaata cacccattgc agacatctat gcctatctcc aacggcaggc ggaacaacgt     6720

ttactcatcg acaaatctcc cagctacggc agcgatcgcc atattctaga ccacagcgaa     6780

atcctctttg accaggccaa atatatccat ctggtacgcc atccctacgc ggtgattgaa     6840

tcctttaccc gactgcggat ggataaactg ctgggggccg agcagcagaa cccctacgcc     6900

ctcgcggagt ccatttggcg caccagcaac cgcaatattt tagacctggg tcgcacggtt     6960

ggtgcggatc gatatctcca ggtgatttac gaagatctcg tccgtgaccc ccgcaaagtt     7020

ttgacaaata tttgtgattt cctgggggtg gactttgacg aagcgctcct caatccctac     7080

agcggcgatc gccttaccga tggcctccac caacagtcca tgggcgtcgg ggatcccaat     7140

ttcctccagc acaaaaccat tgatccggcc ctcgccgaca aatggcgctc aattaccctg     7200

cccgctgctc tccagctgga tacgatccag ttggccgaaa cgtttgctta cgatctcccc     7260

caggaacccc agctaacacc ccagacccaa tccttgccct cgatggtgga gcggttcgtg     7320

acagtgcgcg gtttagaaac ctgtctctgt gagtggggcg atcgccacca accattggtg     7380

ctacttctcc acggcatcct cgaacagggg gcctcctggc aactcatcgc gccccagttg     7440

gcggcccagg gctattgggt tgtggcccca gacctgcgtg gtcacggcaa atccgcccat     7500

gcccagtcct acagcatgct tgattttttg gctgacgtag atgcccttgc caaacaatta     7560

ggcgatcgcc cctttacctt ggtgggccac tccatgggtt ccatcatcgg tgccatgtat     7620

gcaggaattc gccaaaccca ggtagaaaag ttgatcctcg ttgaaaccat tgtccccaac     7680

gacatcgacg acgctgaaac cggtaatcac ctgacgaccc atctcgatta cctcgccgcg     7740

cccccccaac acccgatctt ccccagccta gaagtggccg cccgtcgcct ccgccaagcc     7800

acgccccaac tacccaaaga cctctcggcg ttcctcaccc agcgcagcac caaatccgtc     7860

gaaaaagggg tgcagtggcg ttgggatgct ttcctccgta cccgggcggg cattgaattc     7920

aatggcatta gcagacgacg ttacctggcc ctgctcaaag atatccaagc gccgatcacc     7980

ctcatctatg gcgatcagag tgaatttaac cgccctgctg atctccaggc gatccaagcg     8040

gctctccccc aggcccaacg tttaacggtt gctggcggcc ataacctcca ttttgagaat     8100

ccccaggcga tcgcccaaat tgtttatcaa caactccaga cccctgtacc caaaacacaa     8160

taa                                                                   8163


<210> 22
<211> 2720
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Val Gly Gln Phe Ala Asn Phe Val Asp Leu Leu Gln Tyr Arg Ala 
1               5                   10                  15      


Lys Leu Gln Ala Arg Lys Thr Val Phe Ser Phe Leu Ala Asp Gly Glu 
            20                  25                  30          


Ala Glu Ser Ala Ala Leu Thr Tyr Gly Glu Leu Asp Gln Lys Ala Gln 
        35                  40                  45              


Ala Ile Ala Ala Phe Leu Gln Ala Asn Gln Ala Gln Gly Gln Arg Ala 
    50                  55                  60                  


Leu Leu Leu Tyr Pro Pro Gly Leu Glu Phe Ile Gly Ala Phe Leu Gly 
65                  70                  75                  80  


Cys Leu Tyr Ala Gly Val Val Ala Val Pro Ala Tyr Pro Pro Arg Pro 
                85                  90                  95      


Asn Lys Ser Phe Asp Arg Leu His Ser Ile Ile Gln Asp Ala Gln Ala 
            100                 105                 110         


Lys Phe Ala Leu Thr Thr Thr Glu Leu Lys Asp Lys Ile Ala Asp Arg 
        115                 120                 125             


Leu Glu Ala Leu Glu Gly Thr Asp Phe His Cys Leu Ala Thr Asp Gln 
    130                 135                 140                 


Val Glu Leu Ile Ser Gly Lys Asn Trp Gln Lys Pro Asn Ile Ser Gly 
145                 150                 155                 160 


Thr Asp Leu Ala Phe Leu Gln Tyr Thr Ser Gly Ser Thr Gly Asp Pro 
                165                 170                 175     


Lys Gly Val Met Val Ser His His Asn Leu Ile His Asn Ser Gly Leu 
            180                 185                 190         


Leu Ala Glu Ala Cys Glu Leu Thr Ala Ala Thr Pro Met Gly Gly Trp 
        195                 200                 205             


Leu Pro Met Tyr His Asp Met Gly Leu Leu Gly Thr Leu Thr Pro Ala 
    210                 215                 220                 


Leu Tyr Leu Gly Thr Thr Cys Val Leu Met Ser Ser Thr Ala Phe Ile 
225                 230                 235                 240 


Lys Arg Pro His Leu Trp Leu Arg Thr Ile Asp Arg Phe Gly Leu Val 
                245                 250                 255     


Trp Ser Ser Ala Pro Asp Phe Ala Tyr Asp Met Cys Leu Lys Arg Val 
            260                 265                 270         


Thr Asp Glu Gln Ile Ala Gly Leu Asp Leu Ser Arg Trp Arg Trp Ala 
        275                 280                 285             


Gly Asn Gly Ala Glu Pro Ile Arg Ala Val Thr Leu Glu Asn Phe Ala 
    290                 295                 300                 


Lys Thr Phe Ala Thr Ala Gly Phe Gln Lys Ser Ala Phe Tyr Pro Cys 
305                 310                 315                 320 


Tyr Gly Met Ala Glu Thr Thr Leu Ile Val Ser Gly Gly Asn Gly Arg 
                325                 330                 335     


Ala Gln Leu Pro Gln Glu Ile Ile Val Ser Lys Gln Gly Ile Glu Ala 
            340                 345                 350         


Asn Gln Val Arg Pro Ala Gln Gly Thr Glu Thr Thr Val Thr Leu Val 
        355                 360                 365             


Gly Ser Gly Glu Val Ile Gly Asp Gln Ile Val Lys Ile Val Asp Pro 
    370                 375                 380                 


Gln Ala Leu Thr Glu Cys Thr Val Gly Glu Ile Gly Glu Val Trp Val 
385                 390                 395                 400 


Lys Gly Glu Ser Val Ala Gln Gly Tyr Trp Gln Lys Pro Asp Leu Thr 
                405                 410                 415     


Gln Gln Gln Phe Gln Gly Asn Val Gly Ala Glu Thr Gly Phe Leu Arg 
            420                 425                 430         


Thr Gly Asp Leu Gly Phe Leu Gln Gly Gly Glu Leu Tyr Ile Thr Gly 
        435                 440                 445             


Arg Leu Lys Asp Leu Leu Ile Ile Arg Gly Arg Asn His Tyr Pro Gln 
    450                 455                 460                 


Asp Ile Glu Leu Thr Val Glu Val Ala His Pro Ala Leu Arg Gln Gly 
465                 470                 475                 480 


Ala Gly Ala Ala Val Ser Val Asp Val Asn Gly Glu Glu Gln Leu Val 
                485                 490                 495     


Ile Val Gln Glu Val Glu Arg Lys Tyr Ala Arg Lys Leu Asn Val Ala 
            500                 505                 510         


Ala Val Ala Gln Ala Ile Arg Gly Ala Ile Ala Ala Glu His Gln Leu 
        515                 520                 525             


Gln Pro Gln Ala Ile Cys Phe Ile Lys Pro Gly Ser Ile Pro Lys Thr 
    530                 535                 540                 


Ser Ser Gly Lys Ile Arg Arg His Ala Cys Lys Ala Gly Phe Leu Asp 
545                 550                 555                 560 


Gly Ser Leu Ala Val Val Gly Glu Trp Gln Pro Ser His Gln Lys Glu 
                565                 570                 575     


Gly Lys Gly Ile Gly Thr Gln Ala Val Thr Pro Ser Thr Thr Thr Ser 
            580                 585                 590         


Thr Asn Phe Pro Leu Pro Asp Gln His Gln Gln Gln Ile Glu Ala Trp 
        595                 600                 605             


Leu Lys Asp Asn Ile Ala His Arg Leu Gly Ile Thr Pro Gln Gln Leu 
    610                 615                 620                 


Asp Glu Thr Glu Pro Phe Ala Ser Tyr Gly Leu Asp Ser Val Gln Ala 
625                 630                 635                 640 


Val Gln Val Thr Ala Asp Leu Glu Asp Trp Leu Gly Arg Lys Leu Asp 
                645                 650                 655     


Pro Thr Leu Ala Tyr Asp Tyr Pro Thr Ile Arg Thr Leu Ala Gln Phe 
            660                 665                 670         


Leu Val Gln Gly Asn Gln Ala Leu Glu Lys Ile Pro Gln Val Pro Lys 
        675                 680                 685             


Ile Gln Gly Lys Glu Ile Ala Val Val Gly Leu Ser Cys Arg Phe Pro 
    690                 695                 700                 


Gln Ala Asp Asn Pro Glu Ala Phe Trp Glu Leu Leu Arg Asn Gly Lys 
705                 710                 715                 720 


Asp Gly Val Arg Pro Leu Lys Thr Arg Trp Ala Thr Gly Glu Trp Gly 
                725                 730                 735     


Gly Phe Leu Glu Asp Ile Asp Gln Phe Glu Pro Gln Phe Phe Gly Ile 
            740                 745                 750         


Ser Pro Arg Glu Ala Glu Gln Met Asp Pro Gln Gln Arg Leu Leu Leu 
        755                 760                 765             


Glu Val Thr Trp Glu Ala Leu Glu Arg Ala Asn Ile Pro Ala Glu Ser 
    770                 775                 780                 


Leu Arg His Ser Gln Thr Gly Val Phe Val Gly Ile Ser Asn Ser Asp 
785                 790                 795                 800 


Tyr Ala Gln Leu Gln Val Arg Glu Asn Asn Pro Ile Asn Pro Tyr Met 
                805                 810                 815     


Gly Thr Gly Asn Ala His Ser Ile Ala Ala Asn Arg Leu Ser Tyr Phe 
            820                 825                 830         


Leu Asp Leu Arg Gly Val Ser Leu Ser Ile Asp Thr Ala Cys Ser Ser 
        835                 840                 845             


Ser Leu Val Ala Val His Leu Ala Cys Gln Ser Leu Ile Asn Gly Glu 
    850                 855                 860                 


Ser Glu Leu Ala Ile Ala Ala Gly Val Asn Leu Ile Leu Thr Pro Asp 
865                 870                 875                 880 


Val Thr Gln Thr Phe Thr Gln Ala Gly Met Met Ser Lys Thr Gly Arg 
                885                 890                 895     


Cys Gln Thr Phe Asp Ala Glu Ala Asp Gly Tyr Val Arg Gly Glu Gly 
            900                 905                 910         


Cys Gly Val Val Leu Leu Lys Pro Leu Ala Gln Ala Glu Arg Asp Gly 
        915                 920                 925             


Asp Asn Ile Leu Ala Val Ile His Gly Ser Ala Val Asn Gln Asp Gly 
    930                 935                 940                 


Arg Ser Asn Gly Leu Thr Ala Pro Asn Gly Arg Ser Gln Gln Ala Val 
945                 950                 955                 960 


Ile Arg Gln Ala Leu Ala Gln Ala Gly Ile Thr Ala Ala Asp Leu Ala 
                965                 970                 975     


Tyr Leu Glu Ala His Gly Thr Gly Thr Pro Leu Gly Asp Pro Ile Glu 
            980                 985                 990         


Ile Asn Ser Leu Lys Ala Val Leu  Gln Thr Ala Gln Arg  Glu Gln Pro 
        995                 1000                 1005             


Cys Val  Val Gly Ser Val Lys  Thr Asn Ile Gly His  Leu Glu Ala 
    1010                 1015                 1020             


Ala Ala  Gly Ile Ala Gly Leu  Ile Lys Val Ile Leu  Ser Leu Glu 
    1025                 1030                 1035             


His Gly  Met Ile Pro Gln His  Leu His Phe Lys Gln  Leu Asn Pro 
    1040                 1045                 1050             


Arg Ile  Asp Leu Asp Gly Leu  Val Thr Ile Ala Ser  Lys Asp Gln 
    1055                 1060                 1065             


Pro Trp  Ser Gly Gly Ser Gln  Lys Arg Phe Ala Gly  Val Ser Ser 
    1070                 1075                 1080             


Phe Gly  Phe Gly Gly Thr Asn  Ala His Val Ile Val  Gly Asp Tyr 
    1085                 1090                 1095             


Ala Gln  Gln Lys Ser Pro Leu  Ala Pro Pro Ala Thr  Gln Asp Arg 
    1100                 1105                 1110             


Pro Trp  His Leu Leu Thr Leu  Ser Ala Lys Asn Ala  Gln Ala Leu 
    1115                 1120                 1125             


Asn Ala  Leu Gln Lys Ser Tyr  Gly Asp Tyr Leu Ala  Gln His Pro 
    1130                 1135                 1140             


Ser Val  Asp Pro Arg Asp Leu  Cys Leu Ser Ala Asn  Thr Gly Arg 
    1145                 1150                 1155             


Ser Pro  Leu Lys Glu Arg Arg  Phe Phe Val Phe Lys  Gln Val Ala 
    1160                 1165                 1170             


Asp Leu  Gln Gln Thr Leu Asn  Gln Asp Phe Leu Ala  Gln Pro Arg 
    1175                 1180                 1185             


Leu Ser  Ser Pro Ala Lys Ile  Ala Phe Leu Phe Thr  Gly Gln Gly 
    1190                 1195                 1200             


Ser Gln  Tyr Tyr Gly Met Gly  Gln Gln Leu Tyr Gln  Thr Ser Pro 
    1205                 1210                 1215             


Val Phe  Arg Gln Val Leu Asp  Glu Cys Asp Arg Leu  Trp Gln Thr 
    1220                 1225                 1230             


Tyr Ser  Pro Glu Ala Pro Ala  Leu Thr Asp Leu Leu  Tyr Gly Asn 
    1235                 1240                 1245             


His Asn  Pro Asp Leu Val His  Glu Thr Val Tyr Thr  Gln Pro Leu 
    1250                 1255                 1260             


Leu Phe  Ala Val Glu Tyr Ala  Ile Ala Gln Leu Trp  Leu Ser Trp 
    1265                 1270                 1275             


Gly Val  Thr Pro Asp Phe Cys  Met Gly His Ser Val  Gly Glu Tyr 
    1280                 1285                 1290             


Val Ala  Ala Cys Leu Ala Gly  Val Phe Ser Leu Ala  Asp Gly Met 
    1295                 1300                 1305             


Lys Leu  Ile Thr Ala Arg Gly  Lys Leu Met His Ala  Leu Pro Ser 
    1310                 1315                 1320             


Asn Gly  Ser Met Ala Ala Val  Phe Ala Asp Lys Thr  Val Ile Lys 
    1325                 1330                 1335             


Pro Tyr  Leu Ser Glu His Leu  Thr Val Gly Ala Glu  Asn Gly Ser 
    1340                 1345                 1350             


His Leu  Val Leu Ser Gly Lys  Thr Pro Cys Leu Glu  Ala Ser Ile 
    1355                 1360                 1365             


His Lys  Leu Gln Ser Gln Gly  Ile Lys Thr Lys Pro  Leu Lys Val 
    1370                 1375                 1380             


Ser His  Ala Phe His Ser Pro  Leu Met Ala Pro Met  Leu Ala Glu 
    1385                 1390                 1395             


Phe Arg  Glu Ile Ala Glu Gln  Ile Thr Phe His Pro  Pro Arg Ile 
    1400                 1405                 1410             


Pro Leu  Ile Ser Asn Val Thr  Gly Gly Gln Ile Glu  Ala Glu Ile 
    1415                 1420                 1425             


Ala Gln  Ala Asp Tyr Trp Val  Lys His Val Ser Gln  Pro Val Lys 
    1430                 1435                 1440             


Phe Val  Gln Ser Ile Gln Thr  Leu Ala Gln Ala Gly  Val Asn Val 
    1445                 1450                 1455             


Tyr Leu  Glu Ile Gly Val Lys  Pro Val Leu Leu Ser  Met Gly Arg 
    1460                 1465                 1470             


His Cys  Leu Ala Glu Gln Glu  Ala Val Trp Leu Pro  Ser Leu Arg 
    1475                 1480                 1485             


Pro His  Ser Glu Pro Trp Pro  Glu Ile Leu Thr Ser  Leu Gly Lys 
    1490                 1495                 1500             


Leu Tyr  Glu Gln Gly Leu Asn  Ile Asp Trp Gln Thr  Val Glu Ala 
    1505                 1510                 1515             


Gly Asp  Arg Arg Arg Lys Leu  Ile Leu Pro Thr Tyr  Pro Phe Gln 
    1520                 1525                 1530             


Arg Gln  Arg Tyr Trp Phe Asn  Gln Gly Ser Trp Gln  Thr Val Glu 
    1535                 1540                 1545             


Thr Glu  Ser Val Asn Pro Gly  Pro Asp Asp Leu Asn  Asp Trp Leu 
    1550                 1555                 1560             


Tyr Gln  Val Ala Trp Thr Pro  Leu Asp Thr Leu Pro  Pro Ala Pro 
    1565                 1570                 1575             


Glu Pro  Ser Ala Lys Leu Trp  Leu Ile Leu Gly Asp  Arg His Asp 
    1580                 1585                 1590             


His Gln  Pro Ile Glu Ala Gln  Phe Lys Asn Ala Gln  Arg Val Tyr 
    1595                 1600                 1605             


Leu Gly  Gln Ser Asn His Phe  Pro Thr Asn Ala Pro  Trp Glu Val 
    1610                 1615                 1620             


Ser Ala  Asp Ala Leu Asp Asn  Leu Phe Thr His Val  Gly Ser Gln 
    1625                 1630                 1635             


Asn Leu  Ala Gly Ile Leu Tyr  Leu Cys Pro Pro Gly  Glu Asp Pro 
    1640                 1645                 1650             


Glu Asp  Leu Asp Glu Ile Gln  Lys Gln Thr Ser Gly  Phe Ala Leu 
    1655                 1660                 1665             


Gln Leu  Ile Gln Thr Leu Tyr  Gln Gln Lys Ile Ala  Val Pro Cys 
    1670                 1675                 1680             


Trp Phe  Val Thr His Gln Ser  Gln Arg Val Leu Glu  Thr Asp Ala 
    1685                 1690                 1695             


Val Thr  Gly Phe Ala Gln Gly  Gly Leu Trp Gly Leu  Ala Gln Ala 
    1700                 1705                 1710             


Ile Ala  Leu Glu His Pro Glu  Leu Trp Gly Gly Ile  Ile Asp Val 
    1715                 1720                 1725             


Asp Asp  Ser Leu Pro Asn Phe  Ala Gln Ile Cys Gln  Gln Arg Gln 
    1730                 1735                 1740             


Val Gln  Gln Leu Ala Val Arg  His Gln Lys Leu Tyr  Gly Ala Gln 
    1745                 1750                 1755             


Leu Lys  Lys Gln Pro Ser Leu  Pro Gln Lys Asn Leu  Gln Ile Gln 
    1760                 1765                 1770             


Pro Gln  Gln Thr Tyr Leu Val  Thr Gly Gly Leu Gly  Ala Ile Gly 
    1775                 1780                 1785             


Arg Lys  Ile Ala Gln Trp Leu  Ala Ala Ala Gly Ala  Glu Lys Val 
    1790                 1795                 1800             


Ile Leu  Val Ser Arg Arg Ala  Pro Ala Ala Asp Gln  Gln Thr Leu 
    1805                 1810                 1815             


Pro Thr  Asn Ala Val Val Tyr  Pro Cys Asp Leu Ala  Asp Ala Ala 
    1820                 1825                 1830             


Gln Val  Ala Lys Leu Phe Gln  Thr Tyr Pro His Ile  Lys Gly Ile 
    1835                 1840                 1845             


Phe His  Ala Ala Gly Thr Leu  Ala Asp Gly Leu Leu  Gln Gln Gln 
    1850                 1855                 1860             


Thr Trp  Gln Lys Phe Gln Thr  Val Ala Ala Ala Lys  Met Lys Gly 
    1865                 1870                 1875             


Thr Trp  His Leu His Arg His  Ser Gln Lys Leu Asp  Leu Asp Phe 
    1880                 1885                 1890             


Phe Val  Leu Phe Ser Ser Val  Ala Gly Val Leu Gly  Ser Pro Gly 
    1895                 1900                 1905             


Gln Gly  Asn Tyr Ala Ala Ala  Asn Arg Gly Met Ala  Ala Ile Ala 
    1910                 1915                 1920             


Gln Tyr  Arg Gln Ala Gln Gly  Leu Pro Ala Leu Ala  Ile His Trp 
    1925                 1930                 1935             


Gly Pro  Trp Ala Glu Gly Gly  Met Ala Asn Ser Leu  Ser Asn Gln 
    1940                 1945                 1950             


Asn Leu  Ala Trp Leu Pro Pro  Pro Gln Gly Leu Thr  Ile Leu Glu 
    1955                 1960                 1965             


Lys Val  Leu Gly Ala Gln Gly  Glu Met Gly Val Phe  Lys Pro Asp 
    1970                 1975                 1980             


Trp Gln  Asn Leu Ala Lys Gln  Phe Pro Glu Phe Ala  Lys Thr His 
    1985                 1990                 1995             


Tyr Phe  Ala Ala Val Ile Pro  Ser Ala Glu Ala Val  Pro Pro Thr 
    2000                 2005                 2010             


Ala Ser  Ile Phe Asp Lys Leu  Ile Asn Leu Glu Ala  Ser Gln Arg 
    2015                 2020                 2025             


Ala Asp  Tyr Leu Leu Asp Tyr  Leu Arg Arg Ser Val  Ala Gln Ile 
    2030                 2035                 2040             


Leu Lys  Leu Glu Ile Glu Gln  Ile Gln Ser His Asp  Ser Leu Leu 
    2045                 2050                 2055             


Asp Leu  Gly Met Asp Ser Leu  Met Ile Met Glu Ala  Ile Ala Ser 
    2060                 2065                 2070             


Leu Lys  Gln Asp Leu Gln Leu  Met Leu Tyr Pro Arg  Glu Ile Tyr 
    2075                 2080                 2085             


Glu Arg  Pro Arg Leu Asp Val  Leu Thr Ala Tyr Leu  Ala Ala Glu 
    2090                 2095                 2100             


Phe Thr  Lys Ala His Asp Ser  Glu Ala Ala Thr Ala  Ala Ala Ala 
    2105                 2110                 2115             


Ile Pro  Ser Gln Ser Leu Ser  Val Lys Thr Lys Lys  Gln Trp Gln 
    2120                 2125                 2130             


Lys Pro  Asp His Lys Asn Pro  Asn Pro Ile Ala Phe  Ile Leu Ser 
    2135                 2140                 2145             


Ser Pro  Arg Ser Gly Ser Thr  Leu Leu Arg Val Met  Leu Ala Gly 
    2150                 2155                 2160             


His Pro  Gly Leu Tyr Ser Pro  Pro Glu Leu His Leu  Leu Pro Phe 
    2165                 2170                 2175             


Glu Thr  Met Gly Asp Arg His  Gln Glu Leu Gly Leu  Ser His Leu 
    2180                 2185                 2190             


Gly Glu  Gly Leu Gln Arg Ala  Leu Met Asp Leu Glu  Asn Leu Thr 
    2195                 2200                 2205             


Pro Glu  Ala Ser Gln Ala Lys  Val Asn Gln Trp Val  Lys Ala Asn 
    2210                 2215                 2220             


Thr Pro  Ile Ala Asp Ile Tyr  Ala Tyr Leu Gln Arg  Gln Ala Glu 
    2225                 2230                 2235             


Gln Arg  Leu Leu Ile Asp Lys  Ser Pro Ser Tyr Gly  Ser Asp Arg 
    2240                 2245                 2250             


His Ile  Leu Asp His Ser Glu  Ile Leu Phe Asp Gln  Ala Lys Tyr 
    2255                 2260                 2265             


Ile His  Leu Val Arg His Pro  Tyr Ala Val Ile Glu  Ser Phe Thr 
    2270                 2275                 2280             


Arg Leu  Arg Met Asp Lys Leu  Leu Gly Ala Glu Gln  Gln Asn Pro 
    2285                 2290                 2295             


Tyr Ala  Leu Ala Glu Ser Ile  Trp Arg Thr Ser Asn  Arg Asn Ile 
    2300                 2305                 2310             


Leu Asp  Leu Gly Arg Thr Val  Gly Ala Asp Arg Tyr  Leu Gln Val 
    2315                 2320                 2325             


Ile Tyr  Glu Asp Leu Val Arg  Asp Pro Arg Lys Val  Leu Thr Asn 
    2330                 2335                 2340             


Ile Cys  Asp Phe Leu Gly Val  Asp Phe Asp Glu Ala  Leu Leu Asn 
    2345                 2350                 2355             


Pro Tyr  Ser Gly Asp Arg Leu  Thr Asp Gly Leu His  Gln Gln Ser 
    2360                 2365                 2370             


Met Gly  Val Gly Asp Pro Asn  Phe Leu Gln His Lys  Thr Ile Asp 
    2375                 2380                 2385             


Pro Ala  Leu Ala Asp Lys Trp  Arg Ser Ile Thr Leu  Pro Ala Ala 
    2390                 2395                 2400             


Leu Gln  Leu Asp Thr Ile Gln  Leu Ala Glu Thr Phe  Ala Tyr Asp 
    2405                 2410                 2415             


Leu Pro  Gln Glu Pro Gln Leu  Thr Pro Gln Thr Gln  Ser Leu Pro 
    2420                 2425                 2430             


Ser Met  Val Glu Arg Phe Val  Thr Val Arg Gly Leu  Glu Thr Cys 
    2435                 2440                 2445             


Leu Cys  Glu Trp Gly Asp Arg  His Gln Pro Leu Val  Leu Leu Leu 
    2450                 2455                 2460             


His Gly  Ile Leu Glu Gln Gly  Ala Ser Trp Gln Leu  Ile Ala Pro 
    2465                 2470                 2475             


Gln Leu  Ala Ala Gln Gly Tyr  Trp Val Val Ala Pro  Asp Leu Arg 
    2480                 2485                 2490             


Gly His  Gly Lys Ser Ala His  Ala Gln Ser Tyr Ser  Met Leu Asp 
    2495                 2500                 2505             


Phe Leu  Ala Asp Val Asp Ala  Leu Ala Lys Gln Leu  Gly Asp Arg 
    2510                 2515                 2520             


Pro Phe  Thr Leu Val Gly His  Ser Met Gly Ser Ile  Ile Gly Ala 
    2525                 2530                 2535             


Met Tyr  Ala Gly Ile Arg Gln  Thr Gln Val Glu Lys  Leu Ile Leu 
    2540                 2545                 2550             


Val Glu  Thr Ile Val Pro Asn  Asp Ile Asp Asp Ala  Glu Thr Gly 
    2555                 2560                 2565             


Asn His  Leu Thr Thr His Leu  Asp Tyr Leu Ala Ala  Pro Pro Gln 
    2570                 2575                 2580             


His Pro  Ile Phe Pro Ser Leu  Glu Val Ala Ala Arg  Arg Leu Arg 
    2585                 2590                 2595             


Gln Ala  Thr Pro Gln Leu Pro  Lys Asp Leu Ser Ala  Phe Leu Thr 
    2600                 2605                 2610             


Gln Arg  Ser Thr Lys Ser Val  Glu Lys Gly Val Gln  Trp Arg Trp 
    2615                 2620                 2625             


Asp Ala  Phe Leu Arg Thr Arg  Ala Gly Ile Glu Phe  Asn Gly Ile 
    2630                 2635                 2640             


Ser Arg  Arg Arg Tyr Leu Ala  Leu Leu Lys Asp Ile  Gln Ala Pro 
    2645                 2650                 2655             


Ile Thr  Leu Ile Tyr Gly Asp  Gln Ser Glu Phe Asn  Arg Pro Ala 
    2660                 2665                 2670             


Asp Leu  Gln Ala Ile Gln Ala  Ala Leu Pro Gln Ala  Gln Arg Leu 
    2675                 2680                 2685             


Thr Val  Ala Gly Gly His Asn  Leu His Phe Glu Asn  Pro Gln Ala 
    2690                 2695                 2700             


Ile Ala  Gln Ile Val Tyr Gln  Gln Leu Gln Thr Pro  Val Pro Lys 
    2705                 2710                 2715             


Thr Gln  
    2720 


<210> 23
<211> 8286
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 23
catatggcaa gctggtccca cccgcaattc gagaaagaag tacatcacca tcaccatcat       60

ggcgcagtgg gccagtttgc gaactttgta gacctgttgc aataccgtgc caagctgcaa      120

gcacgtaaga ccgtctttag cttcctggcg gacggcgaag cggagagcgc cgctctgacc      180

tatggtgagc tggatcaaaa ggcgcaggca atcgcggcgt tcctgcaagc aaatcaggca      240

caaggccaac gtgcattgct gctgtatccg ccaggtctgg agttcatcgg tgccttcctg      300

ggttgtctgt atgcgggtgt cgtcgcggtt ccggcatatc ctccgcgtcc gaacaagtcc      360

ttcgaccgtt tgcactccat cattcaggac gcccaagcga agtttgcact gacgacgacc      420

gagttgaagg ataagattgc agaccgtctg gaagcgctgg agggtacgga cttccattgc      480

ctggcgaccg accaagtcga gctgatcagc ggcaaaaact ggcaaaagcc gaatatctcc      540

ggtacggatc tggcgtttct gcaatacacc agcggcagca cgggtgatcc aaaaggcgtg      600

atggtcagcc accataacct gattcacaat agcggtctga ttaaccaggg tttccaagac      660

accgaagcga gcatgggtgt gtcctggctg ccgccgtatc acgacatggg tctgattggc      720

ggcatcctgc aacctatcta cgttggcgca acgcaaatcc tgatgccacc agtcgccttt      780

ctgcaacgtc cgttccgctg gctgaaggcg atcaacgatt accgtgtcag caccagcggt      840

gcgccgaact ttgcttacga cctgtgcgct tctcagatta ccccggaaca aatccgcgag      900

ctggatctga gctgttggcg tctggcattc agcggtgcag agccgattcg cgctgtcacg      960

ctggaaaact ttgcgaaaac gttcgcaacc gcgggtttcc agaaatcggc cttctaccct     1020

tgttacggta tggcggaaac caccctgatc gtgagcggtg gcaatggccg tgcccaactg     1080

ccacaggaga tcatcgttag caagcagggc attgaggcga accaagtgcg tccggctcaa     1140

ggcacggaaa cgaccgtgac cctggtgggt agcggtgagg tcattggtga ccagatcgtt     1200

aagatcgttg accctcaagc gctgaccgag tgcaccgtcg gtgaaattgg cgaggtgtgg     1260

gttaaaggtg aaagcgttgc tcagggctac tggcagaagc cggacttgac gcagcagcag     1320

ttccagggta acgtgggtgc cgaaacgggt ttcctgcgca ccggcgatct gggtttcctg     1380

caaggcggcg agctgtatat caccggccgt ctgaaggatc tgctgatcat tcgtggccgt     1440

aatcactatc ctcaggacat tgagctgacc gtggaagttg ctcacccagc cctgcgtcag     1500

ggcgcaggtg ccgcggtgag cgtggacgtt aatggtgaag aacaactggt gatcgttcaa     1560

gaggttgagc gtaagtacgc acgcaagctg aatgtggcag cagtcgctca ggccatccgt     1620

ggtgcgattg cggcagagca ccagttgcag ccgcaggcga tctgctttat caaaccgggc     1680

agcatcccga aaactagcag cggcaaaatc cgtcgtcacg catgtaaggc cggttttctg     1740

gacggaagct tggcggttgt tggtgagtgg caaccgagcc atcagaaaga gggcaaaggt     1800

attggtaccc aggcagtgac cccgagcacc acgacgtcca ccaactttcc gctgccggat     1860

caacaccagc aacagatcga ggcgtggctg aaggacaaca tcgcgcaccg cctgggtatt     1920

acgccgcagc agttggatga aacggaaccg ttcgcttctt acggtctgga cagcgttcaa     1980

gcagtccagg tcaccgcaga cctggaggac tggctgggcc gcaagctgga cccgactctg     2040

gcctatgatt acccgaccat tcgcacgctg gcgcaattcc tggttcaggg caaccaggcc     2100

ttggagaaaa tcccgcaagt tccaaagatt cagggtaaag agattgcggt ggtgggcctg     2160

agctgccgct ttccgcaggc ggacaatccg gaggcgttct gggaactgtt gcgcaatggc     2220

aaggatggcg tgcgtccgct gaaaacccgt tgggccactg gtgagtgggg tggtttcctg     2280

gaggatatcg accagtttga gccgcagttc tttggtatta gcccgcgtga ggcggagcaa     2340

atggacccgc aacagcgtct gctgctggag gtcacctggg aggcactgga gcgtgcgaat     2400

atccctgccg aatccctgcg tcacagccag accggcgtct ttgtgggcat tagcaacagc     2460

gattacgcac aactgcaagt gcgtgagaac aacccgatca atccgtacat gggtactggt     2520

aacgcacata gcatcgcggc gaatcgtctg agctactttc tggatctgcg cggtgtctcc     2580

ctgagcattg ataccgcgtg ttctagcagc ctggtcgcag ttcatctggc gtgccaaagc     2640

ctgattaacg gcgagagcga gctggcgatt gctgcgggtg ttaatctgat tctgaccccg     2700

gatgtcacgc aaacctttac ccaagcgggt atgatgagca agacgggccg ttgccagacg     2760

tttgatgcgg aggcggacgg ctacgtgcgc ggtgaaggct gcggcgttgt tctgctgaaa     2820

ccgctggctc aggcggagcg tgatggcgac aatatcctgg cggtcatcca cggtagcgcg     2880

gttaaccagg acggtcgcag caatggtctg actgcgccga acggccgctc tcagcaagcg     2940

gttatccgtc aggccctggc gcaggcgggc atcaccgcgg cagacctggc gtatttggaa     3000

gcgcatggta cgggcacccc gctgggcgac ccgattgaaa tcaacagctt gaaagcagtg     3060

ctgcaaaccg cccagcgcga gcaaccgtgc gttgtgggca gcgtcaagac gaacattggc     3120

cacctggagg cagcagcggg tattgcaggt ctgatcaagg tgattctgtc cctggagcac     3180

ggcatgattc cgcaacacct gcactttaag caactgaatc cgcgcatcga cctggacggc     3240

ctggttacca tcgcgagcaa agaccagccg tggtcgggtg gtagccagaa gcgtttcgcc     3300

ggtgtcagca gctttggttt tggcggtacg aatgctcacg tgattgttgg tgattatgcc     3360

cagcaaaagt ccccgctggc tccgcctgcg acccaagacc gtccttggca tctgctgact     3420

ctgagcgcga agaacgcaca agcgttgaac gcgttgcaaa agagctatgg tgactacctg     3480

gcgcaacatc cgagcgttga ccctcgcgat ctgtgcctga gcgctaacac tggtcgctct     3540

ccgctgaaag aacgccgctt cttcgtgttc aagcaggttg ccgacttgca acaaaccctg     3600

aatcaggact ttctggcgca gccgaggctg agcagcccag ccaagattgc gttcctgttc     3660

acgggtcagg gcagccagta ctacggtatg ggccagcaac tgtatcagac gtccccggtt     3720

ttccgtcaag tcctggatga atgcgaccgt ctgtggcaga cgtacagccc ggaggcaccg     3780

gcgctgaccg atctgctgta cggcaatcat aatcctgacc tggttcatga aacggtttac     3840

acgcaaccgc tgctgttcgc ggtggagtat gctatcgcgc agttgtggtt gagctggggc     3900

gttactccgg atttctgcat gggtcatagc gtcggtgagt atgtggcggc ctgcctggcg     3960

ggtgtgttta gcctggcgga tggcatgaaa ctgattaccg cgcgtggtaa actgatgcat     4020

gcactgccga gcaatggcag catggcggct gtgtttgcgg acaaaaccgt tatcaagccg     4080

tatctgagcg aacacctgac cgtcggcgca gaaaatggca gccacctggt tctgagcggt     4140

aagacccctt gtctggaagc atccatccac aaactgcaaa gccagggcat caaaaccaag     4200

cctctgaaag tctcccatgc gttccactcg ccgctgatgg cgccgatgct ggcggaattt     4260

cgtgagatcg ccgaacagat tacgttccat ccgccacgta tcccgctgat tagcaacgtg     4320

acgggtggtc aaatcgaggc cgagatcgcg caagcagact attgggttaa acatgttagc     4380

cagccggtga agttcgttca gagcattcag accctggccc aagcgggtgt gaatgtgtac     4440

ctggaaatcg gtgttaaacc agtcctgctg tctatgggtc gccactgtct ggcagagcag     4500

gaagcggttt ggctgccgag cctgcgtcca catagcgagc cttggccgga aatcttgact     4560

agtctgggca aactgtacga gcaaggtctg aatatcgact ggcaaacggt tgaagccggt     4620

gatcgccgtc gtaagctgat tttgccgacc tacccgttcc agcgtcagcg ttattggttc     4680

aaccaaggta gctggcaaac cgtcgaaact gagagcgtga atccaggccc ggacgacctg     4740

aatgactggc tgtaccaagt ggcatggact ccgctggata cgctgccgcc tgcaccggaa     4800

ccgtcggcga aactgtggct gattctgggt gatcgtcacg atcaccaacc gattgaggcc     4860

cagttcaaaa acgcccaacg tgtgtacctg ggccaaagca accactttcc gacgaacgcc     4920

ccgtgggagg tgagcgcgga cgcactggat aacttgttta cccatgtggg tagccaaaac     4980

ctggcaggca ttctgtatct gtgcccgcct ggtgaagatc cggaggatct ggatgagatt     5040

cagaaacaaa cttccggctt tgcgttgcaa ctgattcaga ccctgtatca gcagaaaatc     5100

gcagtgccgt gttggtttgt tacccatcaa agccagcgtg tgctggaaac ggacgcggtg     5160

acgggttttg cccaaggtgg tctgtggggt ttggcgcaag cgattgcact ggaacatccg     5220

gaactgtggg gtggtatcat tgacgtggat gatagcctgc cgaacttcgc gcagatttgt     5280

cagcaacgtc aggttcagca actggctgtc cgtcaccaga aactgtatgg tgcgcaactg     5340

aagaagcagc cgagcctgcc gcagaagaat ctgcagatcc aacctcaaca gacctacctg     5400

gtcacgggcg gtttgggtgc aatcggtcgt aagattgcgc agtggctggc ggctgcgggt     5460

gctgagaaag ttatcctggt tagccgtcgt gcaccggcag cggatcaaca aaccttgccg     5520

accaacgccg tggtgtaccc gtgcgatctg gcggatgcgg cgcaggttgc gaaactgttc     5580

caaacctatc cgcacattaa gggtatcttt catgcagccg gtacgctggc tgacggtttg     5640

ctgcaacagc aaacctggca gaaattccag actgtcgctg cggcgaagat gaagggcacc     5700

tggcacctgc atcgccactc tcagaagttg gacttggatt tctttgtttt gttttcgtct     5760

gttgcgggtg tgctgggtag ccctggtcaa ggcaattacg cggcagccaa ccgtggcatg     5820

gccgccatcg ctcagtaccg ccaggctcaa ggtctgccgg cactggcgat tcactggggc     5880

ccttgggcgg aaggtggtat ggcaaacagc ttgagcaacc aaaatctggc atggttgcct     5940

ccgccgcagg gcttgaccat tctggaaaaa gttttgggtg cccaaggcga aatgggcgtg     6000

ttcaaaccgg actggcagaa cttggccaaa caattcccgg agttcgcgaa aacccattac     6060

tttgcggcgg tcattccgag cgctgaagcg gttccaccga ccgcatctat cttcgacaag     6120

ctgatcaatc tggaagcgag ccagcgcgca gattacctgc tggactatct gcgtagatct     6180

gtggcacaaa ttctgaaact ggaaattgag cagattcaga gccacgactc cctgctggat     6240

ctgggtatgg atagcctgat gatcatggag gcgattgcgt ccctgaaaca agacctgcaa     6300

ctgatgctgt atccgcgtga gatttacgag cgtccgcgtc tggatgttct gactgcttac     6360

ttggccgctg agtttaccaa agcgcatgat tctgaagcag ctaccgccgc agctgcgatc     6420

cctagccaga gcctgagcgt caaaaccaaa aagcaatggc agaaaccgga tcataagaac     6480

ccgaatccga ttgcgttcat cctgagcagc ccgcgtagcg gtagcaccct gctgcgcgtg     6540

atgctggccg gtcacccggg tctgtattcc ccaccggaac tgcacctgct gccgtttgaa     6600

acgatgggtg accgccacca ggaactgggt ctgtctcatc tgggcgaggg tctgcaacgt     6660

gccctgatgg acttggaaaa tctgacgccg gaagcatccc aggcaaaggt gaaccaatgg     6720

gtgaaggcga atacgccgat tgcagacatc tacgcatacc tgcaacgtca agccgagcaa     6780

cgtctgctga ttgacaaaag cccgagctat ggcagcgacc gccacattct ggatcacagc     6840

gagatcctgt tcgatcaggc gaaatacatc cacctggttc gccatcctta tgcggtcatt     6900

gagagcttta cccgcctgcg tatggacaag ctgctgggtg cagagcaaca gaatccgtat     6960

gcgctggcgg aaagcatttg gcgtacctcg aatcgcaaca ttctggactt gggtcgtacc     7020

gtcggcgctg accgctacct gcaagtcatc tacgaggatc tggtgcgtga cccgcgtaaa     7080

gttctgacca acatttgtga ttttctgggt gtcgatttcg acgaggcact gctgaatccg     7140

tactccggcg accgcctgac cgacggcctg caccagcaaa gcatgggtgt gggtgacccg     7200

aacttcttgc agcacaagac cattgatccg gcgctagcgg acaaatggcg tagcattacc     7260

ctgccggctg ctctgcaact ggatacgatt caactggccg aaaccttcgc atacgacctg     7320

ccgcaggagc cgcagttgac gccgcagacc caatctttgc catcgatggt cgaacgtttc     7380

gtcacggttc gcggcctgga aacctgtctg tgcgagtggg gtgatcgcca tcaacctctg     7440

gtcttgctgt tgcacggtat cctggagcaa ggcgcgtctt ggcagttgat cgcgcctcaa     7500

ctggcagcgc agggctattg ggtcgtcgct ccggatctgc gcggtcacgg taaatctgcg     7560

cacgcgcagt cttatagcat gctggatttt ctggccgatg tggacgcgct ggccaaacag     7620

ttgggcgacc gtccgttcac cttggttggt cacagcatgg gttccatcat tggcgcaatg     7680

tatgctggca ttcgtcaaac ccaggttgaa aaactgattc tggtcgaaac catcgtcccg     7740

aatgatattg atgatgccga aaccggcaat cacctgacca cccatctgga ttacctggca     7800

gcccctccgc agcacccgat ctttccgagc ctggaagttg cggctcgtcg tctgcgccaa     7860

gccaccccgc agttgccgaa agacctgtct gcatttctga cgcaacgttc cacgaagagc     7920

gtcgagaagg gtgtgcagtg gcgctgggat gccttcttgc gcacccgtgc aggtatcgag     7980

tttaacggta tcagccgtcg ccgttatctg gcgctgctga aagatatcca ggccccaatt     8040

actttgattt acggtgatca gtctgagttc aatcgcccag cagacctgca agcgatccag     8100

gcggcactgc cgcaagcgca acgcctgacg gttgctggcg gtcacaactt gcactttgag     8160

aatccgcagg ccatcgccca gattgtctat cagcagttgc agacaccggt tccgaaaacc     8220

caaggtttgc accatcacca ccatcatagc gcctggagcc acccgcagtt tgaaaagtaa     8280

gaattc                                                                8286


<210> 24
<211> 2758
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Ala Ser Trp Ser His Pro Gln Phe Glu Lys Glu Val His His His 
1               5                   10                  15      


His His His Gly Ala Val Gly Gln Phe Ala Asn Phe Val Asp Leu Leu 
            20                  25                  30          


Gln Tyr Arg Ala Lys Leu Gln Ala Arg Lys Thr Val Phe Ser Phe Leu 
        35                  40                  45              


Ala Asp Gly Glu Ala Glu Ser Ala Ala Leu Thr Tyr Gly Glu Leu Asp 
    50                  55                  60                  


Gln Lys Ala Gln Ala Ile Ala Ala Phe Leu Gln Ala Asn Gln Ala Gln 
65                  70                  75                  80  


Gly Gln Arg Ala Leu Leu Leu Tyr Pro Pro Gly Leu Glu Phe Ile Gly 
                85                  90                  95      


Ala Phe Leu Gly Cys Leu Tyr Ala Gly Val Val Ala Val Pro Ala Tyr 
            100                 105                 110         


Pro Pro Arg Pro Asn Lys Ser Phe Asp Arg Leu His Ser Ile Ile Gln 
        115                 120                 125             


Asp Ala Gln Ala Lys Phe Ala Leu Thr Thr Thr Glu Leu Lys Asp Lys 
    130                 135                 140                 


Ile Ala Asp Arg Leu Glu Ala Leu Glu Gly Thr Asp Phe His Cys Leu 
145                 150                 155                 160 


Ala Thr Asp Gln Val Glu Leu Ile Ser Gly Lys Asn Trp Gln Lys Pro 
                165                 170                 175     


Asn Ile Ser Gly Thr Asp Leu Ala Phe Leu Gln Tyr Thr Ser Gly Ser 
            180                 185                 190         


Thr Gly Asp Pro Lys Gly Val Met Val Ser His His Asn Leu Ile His 
        195                 200                 205             


Asn Ser Gly Leu Ile Asn Gln Gly Phe Gln Asp Thr Glu Ala Ser Met 
    210                 215                 220                 


Gly Val Ser Trp Leu Pro Pro Tyr His Asp Met Gly Leu Ile Gly Gly 
225                 230                 235                 240 


Ile Leu Gln Pro Ile Tyr Val Gly Ala Thr Gln Ile Leu Met Pro Pro 
                245                 250                 255     


Val Ala Phe Leu Gln Arg Pro Phe Arg Trp Leu Lys Ala Ile Asn Asp 
            260                 265                 270         


Tyr Arg Val Ser Thr Ser Gly Ala Pro Asn Phe Ala Tyr Asp Leu Cys 
        275                 280                 285             


Ala Ser Gln Ile Thr Pro Glu Gln Ile Arg Glu Leu Asp Leu Ser Cys 
    290                 295                 300                 


Trp Arg Leu Ala Phe Ser Gly Ala Glu Pro Ile Arg Ala Val Thr Leu 
305                 310                 315                 320 


Glu Asn Phe Ala Lys Thr Phe Ala Thr Ala Gly Phe Gln Lys Ser Ala 
                325                 330                 335     


Phe Tyr Pro Cys Tyr Gly Met Ala Glu Thr Thr Leu Ile Val Ser Gly 
            340                 345                 350         


Gly Asn Gly Arg Ala Gln Leu Pro Gln Glu Ile Ile Val Ser Lys Gln 
        355                 360                 365             


Gly Ile Glu Ala Asn Gln Val Arg Pro Ala Gln Gly Thr Glu Thr Thr 
    370                 375                 380                 


Val Thr Leu Val Gly Ser Gly Glu Val Ile Gly Asp Gln Ile Val Lys 
385                 390                 395                 400 


Ile Val Asp Pro Gln Ala Leu Thr Glu Cys Thr Val Gly Glu Ile Gly 
                405                 410                 415     


Glu Val Trp Val Lys Gly Glu Ser Val Ala Gln Gly Tyr Trp Gln Lys 
            420                 425                 430         


Pro Asp Leu Thr Gln Gln Gln Phe Gln Gly Asn Val Gly Ala Glu Thr 
        435                 440                 445             


Gly Phe Leu Arg Thr Gly Asp Leu Gly Phe Leu Gln Gly Gly Glu Leu 
    450                 455                 460                 


Tyr Ile Thr Gly Arg Leu Lys Asp Leu Leu Ile Ile Arg Gly Arg Asn 
465                 470                 475                 480 


His Tyr Pro Gln Asp Ile Glu Leu Thr Val Glu Val Ala His Pro Ala 
                485                 490                 495     


Leu Arg Gln Gly Ala Gly Ala Ala Val Ser Val Asp Val Asn Gly Glu 
            500                 505                 510         


Glu Gln Leu Val Ile Val Gln Glu Val Glu Arg Lys Tyr Ala Arg Lys 
        515                 520                 525             


Leu Asn Val Ala Ala Val Ala Gln Ala Ile Arg Gly Ala Ile Ala Ala 
    530                 535                 540                 


Glu His Gln Leu Gln Pro Gln Ala Ile Cys Phe Ile Lys Pro Gly Ser 
545                 550                 555                 560 


Ile Pro Lys Thr Ser Ser Gly Lys Ile Arg Arg His Ala Cys Lys Ala 
                565                 570                 575     


Gly Phe Leu Asp Gly Ser Leu Ala Val Val Gly Glu Trp Gln Pro Ser 
            580                 585                 590         


His Gln Lys Glu Gly Lys Gly Ile Gly Thr Gln Ala Val Thr Pro Ser 
        595                 600                 605             


Thr Thr Thr Ser Thr Asn Phe Pro Leu Pro Asp Gln His Gln Gln Gln 
    610                 615                 620                 


Ile Glu Ala Trp Leu Lys Asp Asn Ile Ala His Arg Leu Gly Ile Thr 
625                 630                 635                 640 


Pro Gln Gln Leu Asp Glu Thr Glu Pro Phe Ala Ser Tyr Gly Leu Asp 
                645                 650                 655     


Ser Val Gln Ala Val Gln Val Thr Ala Asp Leu Glu Asp Trp Leu Gly 
            660                 665                 670         


Arg Lys Leu Asp Pro Thr Leu Ala Tyr Asp Tyr Pro Thr Ile Arg Thr 
        675                 680                 685             


Leu Ala Gln Phe Leu Val Gln Gly Asn Gln Ala Leu Glu Lys Ile Pro 
    690                 695                 700                 


Gln Val Pro Lys Ile Gln Gly Lys Glu Ile Ala Val Val Gly Leu Ser 
705                 710                 715                 720 


Cys Arg Phe Pro Gln Ala Asp Asn Pro Glu Ala Phe Trp Glu Leu Leu 
                725                 730                 735     


Arg Asn Gly Lys Asp Gly Val Arg Pro Leu Lys Thr Arg Trp Ala Thr 
            740                 745                 750         


Gly Glu Trp Gly Gly Phe Leu Glu Asp Ile Asp Gln Phe Glu Pro Gln 
        755                 760                 765             


Phe Phe Gly Ile Ser Pro Arg Glu Ala Glu Gln Met Asp Pro Gln Gln 
    770                 775                 780                 


Arg Leu Leu Leu Glu Val Thr Trp Glu Ala Leu Glu Arg Ala Asn Ile 
785                 790                 795                 800 


Pro Ala Glu Ser Leu Arg His Ser Gln Thr Gly Val Phe Val Gly Ile 
                805                 810                 815     


Ser Asn Ser Asp Tyr Ala Gln Leu Gln Val Arg Glu Asn Asn Pro Ile 
            820                 825                 830         


Asn Pro Tyr Met Gly Thr Gly Asn Ala His Ser Ile Ala Ala Asn Arg 
        835                 840                 845             


Leu Ser Tyr Phe Leu Asp Leu Arg Gly Val Ser Leu Ser Ile Asp Thr 
    850                 855                 860                 


Ala Cys Ser Ser Ser Leu Val Ala Val His Leu Ala Cys Gln Ser Leu 
865                 870                 875                 880 


Ile Asn Gly Glu Ser Glu Leu Ala Ile Ala Ala Gly Val Asn Leu Ile 
                885                 890                 895     


Leu Thr Pro Asp Val Thr Gln Thr Phe Thr Gln Ala Gly Met Met Ser 
            900                 905                 910         


Lys Thr Gly Arg Cys Gln Thr Phe Asp Ala Glu Ala Asp Gly Tyr Val 
        915                 920                 925             


Arg Gly Glu Gly Cys Gly Val Val Leu Leu Lys Pro Leu Ala Gln Ala 
    930                 935                 940                 


Glu Arg Asp Gly Asp Asn Ile Leu Ala Val Ile His Gly Ser Ala Val 
945                 950                 955                 960 


Asn Gln Asp Gly Arg Ser Asn Gly Leu Thr Ala Pro Asn Gly Arg Ser 
                965                 970                 975     


Gln Gln Ala Val Ile Arg Gln Ala Leu Ala Gln Ala Gly Ile Thr Ala 
            980                 985                 990         


Ala Asp Leu Ala Tyr Leu Glu Ala  His Gly Thr Gly Thr  Pro Leu Gly 
        995                 1000                 1005             


Asp Pro  Ile Glu Ile Asn Ser  Leu Lys Ala Val Leu  Gln Thr Ala 
    1010                 1015                 1020             


Gln Arg  Glu Gln Pro Cys Val  Val Gly Ser Val Lys  Thr Asn Ile 
    1025                 1030                 1035             


Gly His  Leu Glu Ala Ala Ala  Gly Ile Ala Gly Leu  Ile Lys Val 
    1040                 1045                 1050             


Ile Leu  Ser Leu Glu His Gly  Met Ile Pro Gln His  Leu His Phe 
    1055                 1060                 1065             


Lys Gln  Leu Asn Pro Arg Ile  Asp Leu Asp Gly Leu  Val Thr Ile 
    1070                 1075                 1080             


Ala Ser  Lys Asp Gln Pro Trp  Ser Gly Gly Ser Gln  Lys Arg Phe 
    1085                 1090                 1095             


Ala Gly  Val Ser Ser Phe Gly  Phe Gly Gly Thr Asn  Ala His Val 
    1100                 1105                 1110             


Ile Val  Gly Asp Tyr Ala Gln  Gln Lys Ser Pro Leu  Ala Pro Pro 
    1115                 1120                 1125             


Ala Thr  Gln Asp Arg Pro Trp  His Leu Leu Thr Leu  Ser Ala Lys 
    1130                 1135                 1140             


Asn Ala  Gln Ala Leu Asn Ala  Leu Gln Lys Ser Tyr  Gly Asp Tyr 
    1145                 1150                 1155             


Leu Ala  Gln His Pro Ser Val  Asp Pro Arg Asp Leu  Cys Leu Ser 
    1160                 1165                 1170             


Ala Asn  Thr Gly Arg Ser Pro  Leu Lys Glu Arg Arg  Phe Phe Val 
    1175                 1180                 1185             


Phe Lys  Gln Val Ala Asp Leu  Gln Gln Thr Leu Asn  Gln Asp Phe 
    1190                 1195                 1200             


Leu Ala  Gln Pro Arg Leu Ser  Ser Pro Ala Lys Ile  Ala Phe Leu 
    1205                 1210                 1215             


Phe Thr  Gly Gln Gly Ser Gln  Tyr Tyr Gly Met Gly  Gln Gln Leu 
    1220                 1225                 1230             


Tyr Gln  Thr Ser Pro Val Phe  Arg Gln Val Leu Asp  Glu Cys Asp 
    1235                 1240                 1245             


Arg Leu  Trp Gln Thr Tyr Ser  Pro Glu Ala Pro Ala  Leu Thr Asp 
    1250                 1255                 1260             


Leu Leu  Tyr Gly Asn His Asn  Pro Asp Leu Val His  Glu Thr Val 
    1265                 1270                 1275             


Tyr Thr  Gln Pro Leu Leu Phe  Ala Val Glu Tyr Ala  Ile Ala Gln 
    1280                 1285                 1290             


Leu Trp  Leu Ser Trp Gly Val  Thr Pro Asp Phe Cys  Met Gly His 
    1295                 1300                 1305             


Ser Val  Gly Glu Tyr Val Ala  Ala Cys Leu Ala Gly  Val Phe Ser 
    1310                 1315                 1320             


Leu Ala  Asp Gly Met Lys Leu  Ile Thr Ala Arg Gly  Lys Leu Met 
    1325                 1330                 1335             


His Ala  Leu Pro Ser Asn Gly  Ser Met Ala Ala Val  Phe Ala Asp 
    1340                 1345                 1350             


Lys Thr  Val Ile Lys Pro Tyr  Leu Ser Glu His Leu  Thr Val Gly 
    1355                 1360                 1365             


Ala Glu  Asn Gly Ser His Leu  Val Leu Ser Gly Lys  Thr Pro Cys 
    1370                 1375                 1380             


Leu Glu  Ala Ser Ile His Lys  Leu Gln Ser Gln Gly  Ile Lys Thr 
    1385                 1390                 1395             


Lys Pro  Leu Lys Val Ser His  Ala Phe His Ser Pro  Leu Met Ala 
    1400                 1405                 1410             


Pro Met  Leu Ala Glu Phe Arg  Glu Ile Ala Glu Gln  Ile Thr Phe 
    1415                 1420                 1425             


His Pro  Pro Arg Ile Pro Leu  Ile Ser Asn Val Thr  Gly Gly Gln 
    1430                 1435                 1440             


Ile Glu  Ala Glu Ile Ala Gln  Ala Asp Tyr Trp Val  Lys His Val 
    1445                 1450                 1455             


Ser Gln  Pro Val Lys Phe Val  Gln Ser Ile Gln Thr  Leu Ala Gln 
    1460                 1465                 1470             


Ala Gly  Val Asn Val Tyr Leu  Glu Ile Gly Val Lys  Pro Val Leu 
    1475                 1480                 1485             


Leu Ser  Met Gly Arg His Cys  Leu Ala Glu Gln Glu  Ala Val Trp 
    1490                 1495                 1500             


Leu Pro  Ser Leu Arg Pro His  Ser Glu Pro Trp Pro  Glu Ile Leu 
    1505                 1510                 1515             


Thr Ser  Leu Gly Lys Leu Tyr  Glu Gln Gly Leu Asn  Ile Asp Trp 
    1520                 1525                 1530             


Gln Thr  Val Glu Ala Gly Asp  Arg Arg Arg Lys Leu  Ile Leu Pro 
    1535                 1540                 1545             


Thr Tyr  Pro Phe Gln Arg Gln  Arg Tyr Trp Phe Asn  Gln Gly Ser 
    1550                 1555                 1560             


Trp Gln  Thr Val Glu Thr Glu  Ser Val Asn Pro Gly  Pro Asp Asp 
    1565                 1570                 1575             


Leu Asn  Asp Trp Leu Tyr Gln  Val Ala Trp Thr Pro  Leu Asp Thr 
    1580                 1585                 1590             


Leu Pro  Pro Ala Pro Glu Pro  Ser Ala Lys Leu Trp  Leu Ile Leu 
    1595                 1600                 1605             


Gly Asp  Arg His Asp His Gln  Pro Ile Glu Ala Gln  Phe Lys Asn 
    1610                 1615                 1620             


Ala Gln  Arg Val Tyr Leu Gly  Gln Ser Asn His Phe  Pro Thr Asn 
    1625                 1630                 1635             


Ala Pro  Trp Glu Val Ser Ala  Asp Ala Leu Asp Asn  Leu Phe Thr 
    1640                 1645                 1650             


His Val  Gly Ser Gln Asn Leu  Ala Gly Ile Leu Tyr  Leu Cys Pro 
    1655                 1660                 1665             


Pro Gly  Glu Asp Pro Glu Asp  Leu Asp Glu Ile Gln  Lys Gln Thr 
    1670                 1675                 1680             


Ser Gly  Phe Ala Leu Gln Leu  Ile Gln Thr Leu Tyr  Gln Gln Lys 
    1685                 1690                 1695             


Ile Ala  Val Pro Cys Trp Phe  Val Thr His Gln Ser  Gln Arg Val 
    1700                 1705                 1710             


Leu Glu  Thr Asp Ala Val Thr  Gly Phe Ala Gln Gly  Gly Leu Trp 
    1715                 1720                 1725             


Gly Leu  Ala Gln Ala Ile Ala  Leu Glu His Pro Glu  Leu Trp Gly 
    1730                 1735                 1740             


Gly Ile  Ile Asp Val Asp Asp  Ser Leu Pro Asn Phe  Ala Gln Ile 
    1745                 1750                 1755             


Cys Gln  Gln Arg Gln Val Gln  Gln Leu Ala Val Arg  His Gln Lys 
    1760                 1765                 1770             


Leu Tyr  Gly Ala Gln Leu Lys  Lys Gln Pro Ser Leu  Pro Gln Lys 
    1775                 1780                 1785             


Asn Leu  Gln Ile Gln Pro Gln  Gln Thr Tyr Leu Val  Thr Gly Gly 
    1790                 1795                 1800             


Leu Gly  Ala Ile Gly Arg Lys  Ile Ala Gln Trp Leu  Ala Ala Ala 
    1805                 1810                 1815             


Gly Ala  Glu Lys Val Ile Leu  Val Ser Arg Arg Ala  Pro Ala Ala 
    1820                 1825                 1830             


Asp Gln  Gln Thr Leu Pro Thr  Asn Ala Val Val Tyr  Pro Cys Asp 
    1835                 1840                 1845             


Leu Ala  Asp Ala Ala Gln Val  Ala Lys Leu Phe Gln  Thr Tyr Pro 
    1850                 1855                 1860             


His Ile  Lys Gly Ile Phe His  Ala Ala Gly Thr Leu  Ala Asp Gly 
    1865                 1870                 1875             


Leu Leu  Gln Gln Gln Thr Trp  Gln Lys Phe Gln Thr  Val Ala Ala 
    1880                 1885                 1890             


Ala Lys  Met Lys Gly Thr Trp  His Leu His Arg His  Ser Gln Lys 
    1895                 1900                 1905             


Leu Asp  Leu Asp Phe Phe Val  Leu Phe Ser Ser Val  Ala Gly Val 
    1910                 1915                 1920             


Leu Gly  Ser Pro Gly Gln Gly  Asn Tyr Ala Ala Ala  Asn Arg Gly 
    1925                 1930                 1935             


Met Ala  Ala Ile Ala Gln Tyr  Arg Gln Ala Gln Gly  Leu Pro Ala 
    1940                 1945                 1950             


Leu Ala  Ile His Trp Gly Pro  Trp Ala Glu Gly Gly  Met Ala Asn 
    1955                 1960                 1965             


Ser Leu  Ser Asn Gln Asn Leu  Ala Trp Leu Pro Pro  Pro Gln Gly 
    1970                 1975                 1980             


Leu Thr  Ile Leu Glu Lys Val  Leu Gly Ala Gln Gly  Glu Met Gly 
    1985                 1990                 1995             


Val Phe  Lys Pro Asp Trp Gln  Asn Leu Ala Lys Gln  Phe Pro Glu 
    2000                 2005                 2010             


Phe Ala  Lys Thr His Tyr Phe  Ala Ala Val Ile Pro  Ser Ala Glu 
    2015                 2020                 2025             


Ala Val  Pro Pro Thr Ala Ser  Ile Phe Asp Lys Leu  Ile Asn Leu 
    2030                 2035                 2040             


Glu Ala  Ser Gln Arg Ala Asp  Tyr Leu Leu Asp Tyr  Leu Arg Arg 
    2045                 2050                 2055             


Ser Val  Ala Gln Ile Leu Lys  Leu Glu Ile Glu Gln  Ile Gln Ser 
    2060                 2065                 2070             


His Asp  Ser Leu Leu Asp Leu  Gly Met Asp Ser Leu  Met Ile Met 
    2075                 2080                 2085             


Glu Ala  Ile Ala Ser Leu Lys  Gln Asp Leu Gln Leu  Met Leu Tyr 
    2090                 2095                 2100             


Pro Arg  Glu Ile Tyr Glu Arg  Pro Arg Leu Asp Val  Leu Thr Ala 
    2105                 2110                 2115             


Tyr Leu  Ala Ala Glu Phe Thr  Lys Ala His Asp Ser  Glu Ala Ala 
    2120                 2125                 2130             


Thr Ala  Ala Ala Ala Ile Pro  Ser Gln Ser Leu Ser  Val Lys Thr 
    2135                 2140                 2145             


Lys Lys  Gln Trp Gln Lys Pro  Asp His Lys Asn Pro  Asn Pro Ile 
    2150                 2155                 2160             


Ala Phe  Ile Leu Ser Ser Pro  Arg Ser Gly Ser Thr  Leu Leu Arg 
    2165                 2170                 2175             


Val Met  Leu Ala Gly His Pro  Gly Leu Tyr Ser Pro  Pro Glu Leu 
    2180                 2185                 2190             


His Leu  Leu Pro Phe Glu Thr  Met Gly Asp Arg His  Gln Glu Leu 
    2195                 2200                 2205             


Gly Leu  Ser His Leu Gly Glu  Gly Leu Gln Arg Ala  Leu Met Asp 
    2210                 2215                 2220             


Leu Glu  Asn Leu Thr Pro Glu  Ala Ser Gln Ala Lys  Val Asn Gln 
    2225                 2230                 2235             


Trp Val  Lys Ala Asn Thr Pro  Ile Ala Asp Ile Tyr  Ala Tyr Leu 
    2240                 2245                 2250             


Gln Arg  Gln Ala Glu Gln Arg  Leu Leu Ile Asp Lys  Ser Pro Ser 
    2255                 2260                 2265             


Tyr Gly  Ser Asp Arg His Ile  Leu Asp His Ser Glu  Ile Leu Phe 
    2270                 2275                 2280             


Asp Gln  Ala Lys Tyr Ile His  Leu Val Arg His Pro  Tyr Ala Val 
    2285                 2290                 2295             


Ile Glu  Ser Phe Thr Arg Leu  Arg Met Asp Lys Leu  Leu Gly Ala 
    2300                 2305                 2310             


Glu Gln  Gln Asn Pro Tyr Ala  Leu Ala Glu Ser Ile  Trp Arg Thr 
    2315                 2320                 2325             


Ser Asn  Arg Asn Ile Leu Asp  Leu Gly Arg Thr Val  Gly Ala Asp 
    2330                 2335                 2340             


Arg Tyr  Leu Gln Val Ile Tyr  Glu Asp Leu Val Arg  Asp Pro Arg 
    2345                 2350                 2355             


Lys Val  Leu Thr Asn Ile Cys  Asp Phe Leu Gly Val  Asp Phe Asp 
    2360                 2365                 2370             


Glu Ala  Leu Leu Asn Pro Tyr  Ser Gly Asp Arg Leu  Thr Asp Gly 
    2375                 2380                 2385             


Leu His  Gln Gln Ser Met Gly  Val Gly Asp Pro Asn  Phe Leu Gln 
    2390                 2395                 2400             


His Lys  Thr Ile Asp Pro Ala  Leu Ala Asp Lys Trp  Arg Ser Ile 
    2405                 2410                 2415             


Thr Leu  Pro Ala Ala Leu Gln  Leu Asp Thr Ile Gln  Leu Ala Glu 
    2420                 2425                 2430             


Thr Phe  Ala Tyr Asp Leu Pro  Gln Glu Pro Gln Leu  Thr Pro Gln 
    2435                 2440                 2445             


Thr Gln  Ser Leu Pro Ser Met  Val Glu Arg Phe Val  Thr Val Arg 
    2450                 2455                 2460             


Gly Leu  Glu Thr Cys Leu Cys  Glu Trp Gly Asp Arg  His Gln Pro 
    2465                 2470                 2475             


Leu Val  Leu Leu Leu His Gly  Ile Leu Glu Gln Gly  Ala Ser Trp 
    2480                 2485                 2490             


Gln Leu  Ile Ala Pro Gln Leu  Ala Ala Gln Gly Tyr  Trp Val Val 
    2495                 2500                 2505             


Ala Pro  Asp Leu Arg Gly His  Gly Lys Ser Ala His  Ala Gln Ser 
    2510                 2515                 2520             


Tyr Ser  Met Leu Asp Phe Leu  Ala Asp Val Asp Ala  Leu Ala Lys 
    2525                 2530                 2535             


Gln Leu  Gly Asp Arg Pro Phe  Thr Leu Val Gly His  Ser Met Gly 
    2540                 2545                 2550             


Ser Ile  Ile Gly Ala Met Tyr  Ala Gly Ile Arg Gln  Thr Gln Val 
    2555                 2560                 2565             


Glu Lys  Leu Ile Leu Val Glu  Thr Ile Val Pro Asn  Asp Ile Asp 
    2570                 2575                 2580             


Asp Ala  Glu Thr Gly Asn His  Leu Thr Thr His Leu  Asp Tyr Leu 
    2585                 2590                 2595             


Ala Ala  Pro Pro Gln His Pro  Ile Phe Pro Ser Leu  Glu Val Ala 
    2600                 2605                 2610             


Ala Arg  Arg Leu Arg Gln Ala  Thr Pro Gln Leu Pro  Lys Asp Leu 
    2615                 2620                 2625             


Ser Ala  Phe Leu Thr Gln Arg  Ser Thr Lys Ser Val  Glu Lys Gly 
    2630                 2635                 2640             


Val Gln  Trp Arg Trp Asp Ala  Phe Leu Arg Thr Arg  Ala Gly Ile 
    2645                 2650                 2655             


Glu Phe  Asn Gly Ile Ser Arg  Arg Arg Tyr Leu Ala  Leu Leu Lys 
    2660                 2665                 2670             


Asp Ile  Gln Ala Pro Ile Thr  Leu Ile Tyr Gly Asp  Gln Ser Glu 
    2675                 2680                 2685             


Phe Asn  Arg Pro Ala Asp Leu  Gln Ala Ile Gln Ala  Ala Leu Pro 
    2690                 2695                 2700             


Gln Ala  Gln Arg Leu Thr Val  Ala Gly Gly His Asn  Leu His Phe 
    2705                 2710                 2715             


Glu Asn  Pro Gln Ala Ile Ala  Gln Ile Val Tyr Gln  Gln Leu Gln 
    2720                 2725                 2730             


Thr Pro  Val Pro Lys Thr Gln  Gly Leu His His His  His His His 
    2735                 2740                 2745             


Ser Ala  Trp Ser His Pro Gln  Phe Glu Lys 
    2750                 2755             


<210> 25
<211> 683
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 25
tcatgaaaat ttacggcatt tacatggacc gtcctttgag ccaagaagaa aatgagcgtt       60

ttatgtcgtt catcagcccg gaaaaacgcg agaagtgccg tcgtttctat cataaggagg      120

atgcccatcg cacgctgctg ggtgatgttc tggttcgttc cgtgatctcc cgccaatacc      180

agctggacaa aagcgatatc cgcttttcca cccaggagta cggcaaacca tgtatcccgg      240

acctgccgga cgctcacttc aacattagcc acagcggtcg ttgggtgatt tgtgcgttcg      300

atagccagcc gattggtatt gacattgaaa agacgaagcc tattagcctg gagatcgcca      360

agcgcttctt cagcaaaacc gagtatagcg atctgctggc gaaagacaaa gacgagcaaa      420

ccgactactt ttaccacctg tggagcatga aagaaagctt tatcaagcaa gaaggtaagg      480

gtttgagctt gccgctggac agctttagcg tgcgtctgca tcaggatggt caggtcagca      540

tcgagctgcc ggactctcac tctccgtgct atattaaaac ctacgaggtc gatccgggct      600

ataaaatggc ggtttgcgca gcacacccgg actttccgga ggatatcact atggtgagct      660

atgaagagtt gctgtaagaa ttc                                              683


<210> 26
<211> 8277
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
atggcaagct ggtcccaccc gcaattcgag aaagaagtac atcaccatca ccatcatggc       60

gcagtgggcc agtttgcgaa ctttgtagac ctgttgcaat accgtgccaa gctgcaagca      120

cgtaagaccg tctttagctt cctggcggac ggcgaagcgg agagcgccgc tctgacctat      180

ggtgagctgg atcaaaaggc gcaggcaatc gcggcgttcc tgcaagcaaa tcaggcacaa      240

ggccaacgtg cattgctgct gtatccgcca ggtctggagt tcatcggtgc cttcctgggt      300

tgtctgtatg cgggtgtcgt cgcggttccg gcatatcctc cgcgtccgaa caagtccttc      360

gaccgtttgc actccatcat tcaggacgcc caagcgaagt ttgcactgac gacgaccgag      420

ttgaaggata agattgcaga ccgtctggaa gcgctggagg gtacggactt ccattgcctg      480

gcgaccgacc aagtcgagct gatcagcggc aaaaactggc aaaagccgaa tatctccggt      540

acggatctgg cgtttctgca atacaccagc ggcagcacgg gtgatccaaa aggcgtgatg      600

gtcagccacc ataacctgat tcacaatagc ggtctgttgg cggaagcgtg cgaactgacc      660

gctgcgaccc cgatgggcgg ttggctgccg atgtaccatg atatgggctt gctgggtact      720

ctgacgccag cgttgtacct gggtactacc tgtgtcctga tgtctagcac cgccttcatc      780

aaacgcccgc atctgtggct gcgcaccatt gatcgctttg gtctggtttg gtctagcgct      840

ccggatttcg cgtacgatat gtgcctgaaa cgtgttaccg atgagcagat tgcgggtctg      900

gatctgtctc gctggcgctg ggcgggtaac ggtgcagagc cgattcgcgc tgtcacgctg      960

gaaaactttg cgaaaacgtt cgcaaccgcg ggtttccaga aatcggcctt ctacccttgt     1020

tacggtatgg cggaaaccac cctgatcgtg agcggtggca atggccgtgc ccaactgcca     1080

caggagatca tcgttagcaa gcagggcatt gaggcgaacc aagtgcgtcc ggctcaaggc     1140

acggaaacga ccgtgaccct ggtgggtagc ggtgaggtca ttggtgacca gatcgttaag     1200

atcgttgacc ctcaagcgct gaccgagtgc accgtcggtg aaattggcga ggtgtgggtt     1260

aaaggtgaaa gcgttgctca gggctactgg cagaagccgg acttgacgca gcagcagttc     1320

cagggtaacg tgggtgccga aacgggtttc ctgcgcaccg gcgatctggg tttcctgcaa     1380

ggcggcgagc tgtatatcac cggccgtctg aaggatctgc tgatcattcg tggccgtaat     1440

cactatcctc aggacattga gctgaccgtg gaagttgctc acccagccct gcgtcagggc     1500

gcaggtgccg cggtgagcgt ggacgttaat ggtgaagaac aactggtgat cgttcaagag     1560

gttgagcgta agtacgcacg caagctgaat gtggcagcag tcgctcaggc catccgtggt     1620

gcgattgcgg cagagcacca gttgcagccg caggcgatct gctttatcaa accgggcagc     1680

atcccgaaaa ctagcagcgg caaaatccgt cgtcacgcat gtaaggccgg ttttctggac     1740

ggaagcttgg cggttgttgg tgagtggcaa ccgagccatc agaaagaggg caaaggtatt     1800

ggtacccagg cagtgacccc gagcaccacg acgtccacca actttccgct gccggatcaa     1860

caccagcaac agatcgaggc gtggctgaag gacaacatcg cgcaccgcct gggtattacg     1920

ccgcagcagt tggatgaaac ggaaccgttc gcttcttacg gtctggacag cgttcaagca     1980

gtccaggtca ccgcagacct ggaggactgg ctgggccgca agctggaccc gactctggcc     2040

tatgattacc cgaccattcg cacgctggcg caattcctgg ttcagggcaa ccaggccttg     2100

gagaaaatcc cgcaagttcc aaagattcag ggtaaagaga ttgcggtggt gggcctgagc     2160

tgccgctttc cgcaggcgga caatccggag gcgttctggg aactgttgcg caatggcaag     2220

gatggcgtgc gtccgctgaa aacccgttgg gccactggtg agtggggtgg tttcctggag     2280

gatatcgacc agtttgagcc gcagttcttt ggtattagcc cgcgtgaggc ggagcaaatg     2340

gacccgcaac agcgtctgct gctggaggtc acctgggagg cactggagcg tgcgaatatc     2400

cctgccgaat ccctgcgtca cagccagacc ggcgtctttg tgggcattag caacagcgat     2460

tacgcacaac tgcaagtgcg tgagaacaac ccgatcaatc cgtacatggg tactggtaac     2520

gcacatagca tcgcggcgaa tcgtctgagc tactttctgg atctgcgcgg tgtctccctg     2580

agcattgata ccgcgtgttc tagcagcctg gtcgcagttc atctggcgtg ccaaagcctg     2640

attaacggcg agagcgagct ggcgattgct gcgggtgtta atctgattct gaccccggat     2700

gtcacgcaaa cctttaccca agcgggtatg atgagcaaga cgggccgttg ccagacgttt     2760

gatgcggagg cggacggcta cgtgcgcggt gaaggctgcg gcgttgttct gctgaaaccg     2820

ctggctcagg cggagcgtga tggcgacaat atcctggcgg tcatccacgg tagcgcggtt     2880

aaccaggacg gtcgcagcaa tggtctgact gcgccgaacg gccgctctca gcaagcggtt     2940

atccgtcagg ccctggcgca ggcgggcatc accgcggcag acctggcgta tttggaagcg     3000

catggtacgg gcaccccgct gggcgacccg attgaaatca acagcttgaa agcagtgctg     3060

caaaccgccc agcgcgagca accgtgcgtt gtgggcagcg tcaagacgaa cattggccac     3120

ctggaggcag cagcgggtat tgcaggtctg atcaaggtga ttctgtccct ggagcacggc     3180

atgattccgc aacacctgca ctttaagcaa ctgaatccgc gcatcgacct ggacggcctg     3240

gttaccatcg cgagcaaaga ccagccgtgg tcgggtggta gccagaagcg tttcgccggt     3300

gtcagcagct ttggttttgg cggtacgaat gctcacgtga ttgttggtga ttatgcccag     3360

caaaagtccc cgctggctcc gcctgcgacc caagaccgtc cttggcatct gctgactctg     3420

agcgcgaaga acgcacaagc gttgaacgcg ttgcaaaaga gctatggtga ctacctggcg     3480

caacatccga gcgttgaccc tcgcgatctg tgcctgagcg ctaacactgg tcgctctccg     3540

ctgaaagaac gccgcttctt cgtgttcaag caggttgccg acttgcaaca aaccctgaat     3600

caggactttc tggcgcagcc gaggctgagc agcccagcca agattgcgtt cctgttcacg     3660

ggtcagggca gccagtacta cggtatgggc cagcaactgt atcagacgtc cccggttttc     3720

cgtcaagtcc tggatgaatg cgaccgtctg tggcagacgt acagcccgga ggcaccggcg     3780

ctgaccgatc tgctgtacgg caatcataat cctgacctgg ttcatgaaac ggtttacacg     3840

caaccgctgc tgttcgcggt ggagtatgct atcgcgcagt tgtggttgag ctggggcgtt     3900

actccggatt tctgcatggg tcatagcgtc ggtgagtatg tggcggcctg cctggcgggt     3960

gtgtttagcc tggcggatgg catgaaactg attaccgcgc gtggtaaact gatgcatgca     4020

ctgccgagca atggcagcat ggcggctgtg tttgcggaca aaaccgttat caagccgtat     4080

ctgagcgaac acctgaccgt cggcgcagaa aatggcagcc acctggttct gagcggtaag     4140

accccttgtc tggaagcatc catccacaaa ctgcaaagcc agggcatcaa aaccaagcct     4200

ctgaaagtct cccatgcgtt ccactcgccg ctgatggcgc cgatgctggc ggaatttcgt     4260

gagatcgccg aacagattac gttccatccg ccacgtatcc cgctgattag caacgtgacg     4320

ggtggtcaaa tcgaggccga gatcgcgcaa gcagactatt gggttaaaca tgttagccag     4380

ccggtgaagt tcgttcagag cattcagacc ctggcccaag cgggtgtgaa tgtgtacctg     4440

gaaatcggtg ttaaaccagt cctgctgtct atgggtcgcc actgtctggc agagcaggaa     4500

gcggtttggc tgccgagcct gcgtccacat agcgagcctt ggccggaaat cttgactagt     4560

ctgggcaaac tgtacgagca aggtctgaat atcgactggc aaacggttga agccggtgat     4620

cgccgtcgta agctgatttt gccgacctac ccgttccagc gtcagcgtta ttggttcaac     4680

caaggtagct ggcaaaccgt cgaaactgag agcgtgaatc caggcccgga cgacctgaat     4740

gactggctgt accaagtggc atggactccg ctggatacgc tgccgcctgc accggaaccg     4800

tcggcgaaac tgtggctgat tctgggtgat cgtcacgatc accaaccgat tgaggcccag     4860

ttcaaaaacg cccaacgtgt gtacctgggc caaagcaacc actttccgac gaacgccccg     4920

tgggaggtga gcgcggacgc actggataac ttgtttaccc atgtgggtag ccaaaacctg     4980

gcaggcattc tgtatctgtg cccgcctggt gaagatccgg aggatctgga tgagattcag     5040

aaacaaactt ccggctttgc gttgcaactg attcagaccc tgtatcagca gaaaatcgca     5100

gtgccgtgtt ggtttgttac ccatcaaagc cagcgtgtgc tggaaacgga cgcggtgacg     5160

ggttttgccc aaggtggtct gtggggtttg gcgcaagcga ttgcactgga acatccggaa     5220

ctgtggggtg gtatcattga cgtggatgat agcctgccga acttcgcgca gatttgtcag     5280

caacgtcagg ttcagcaact ggctgtccgt caccagaaac tgtatggtgc gcaactgaag     5340

aagcagccga gcctgccgca gaagaatctg cagatccaac ctcaacagac ctacctggtc     5400

acgggcggtt tgggtgcaat cggtcgtaag attgcgcagt ggctggcggc tgcgggtgct     5460

gagaaagtta tcctggttag ccgtcgtgca ccggcagcgg atcaacaaac cttgccgacc     5520

aacgccgtgg tgtacccgtg cgatctggcg gatgcggcgc aggttgcgaa actgttccaa     5580

acctatccgc acattaaggg tatctttcat gcagccggta cgctggctga cggtttgctg     5640

caacagcaaa cctggcagaa attccagact gtcgctgcgg cgaagatgaa gggcacctgg     5700

cacctgcatc gccactctca gaagttggac ttggatttct ttgttttgtt ttcgtctgtt     5760

gcgggtgtgc tgggtagccc tggtcaaggc aattacgcgg cagccaaccg tggcatggcc     5820

gccatcgctc agtaccgcca ggctcaaggt ctgccggcac tggcgattca ctggggccct     5880

tgggcggaag gtggtatggc aaacagcttg agcaaccaaa atctggcatg gttgcctccg     5940

ccgcagggct tgaccattct ggaaaaagtt ttgggtgccc aaggcgaaat gggcgtgttc     6000

aaaccggact ggcagaactt ggccaaacaa ttcccggagt tcgcgaaaac ccattacttt     6060

gcggcggtca ttccgagcgc tgaagcggtt ccaccgaccg catctatctt cgacaagctg     6120

atcaatctgg aagcgagcca gcgcgcagat tacctgctgg actatctgcg tagatctgtg     6180

gcacaaattc tgaaactgga aattgagcag attcagagcc acgactccct gctggatctg     6240

ggtatggata gcctgatgat catggaggcg attgcgtccc tgaaacaaga cctgcaactg     6300

atgctgtatc cgcgtgagat ttacgagcgt ccgcgtctgg atgttctgac tgcttacttg     6360

gccgctgagt ttaccaaagc gcatgattct gaagcagcta ccgccgcagc tgcgatccct     6420

agccagagcc tgagcgtcaa aaccaaaaag caatggcaga aaccggatca taagaacccg     6480

aatccgattg cgttcatcct gagcagcccg cgtagcggta gcaccctgct gcgcgtgatg     6540

ctggccggtc acccgggtct gtattcccca ccggaactgc acctgctgcc gtttgaaacg     6600

atgggtgacc gccaccagga actgggtctg tctcatctgg gcgagggtct gcaacgtgcc     6660

ctgatggact tggaaaatct gacgccggaa gcatcccagg caaaggtgaa ccaatgggtg     6720

aaggcgaata cgccgattgc agacatctac gcatacctgc aacgtcaagc cgagcaacgt     6780

ctgctgattg acaaaagccc gagctatggc agcgaccgcc acattctgga tcacagcgag     6840

atcctgttcg atcaggcgaa atacatccac ctggttcgcc atccttatgc ggtcattgag     6900

agctttaccc gcctgcgtat ggacaagctg ctgggtgcag agcaacagaa tccgtatgcg     6960

ctggcggaaa gcatttggcg tacctcgaat cgcaacattc tggacttggg tcgtaccgtc     7020

ggcgctgacc gctacctgca agtcatctac gaggatctgg tgcgtgaccc gcgtaaagtt     7080

ctgaccaaca tttgtgattt tctgggtgtc gatttcgacg aggcactgct gaatccgtac     7140

tccggcgacc gcctgaccga cggcctgcac cagcaaagca tgggtgtggg tgacccgaac     7200

ttcttgcagc acaagaccat tgatccggcg ctagcggaca aatggcgtag cattaccctg     7260

ccggctgctc tgcaactgga tacgattcaa ctggccgaaa ccttcgcata cgacctgccg     7320

caggagccgc agttgacgcc gcagacccaa tctttgccat cgatggtcga acgtttcgtc     7380

acggttcgcg gcctggaaac ctgtctgtgc gagtggggtg atcgccatca acctctggtc     7440

ttgctgttgc acggtatcct ggagcaaggc gcgtcttggc agttgatcgc gcctcaactg     7500

gcagcgcagg gctattgggt cgtcgctccg gatctgcgcg gtcacggtaa atctgcgcac     7560

gcgcagtctt atagcatgct ggattttctg gccgatgtgg acgcgctggc caaacagttg     7620

ggcgaccgtc cgttcacctt ggttggtcac agcatgggtt ccatcattgg cgcaatgtat     7680

gctggcattc gtcaaaccca ggttgaaaaa ctgattctgg tcgaaaccat cgtcccgaat     7740

gatattgatg atgccgaaac cggcaatcac ctgaccaccc atctggatta cctggcagcc     7800

cctccgcagc acccgatctt tccgagcctg gaagttgcgg ctcgtcgtct gcgccaagcc     7860

accccgcagt tgccgaaaga cctgtctgca tttctgacgc aacgttccac gaagagcgtc     7920

gagaagggtg tgcagtggcg ctgggatgcc ttcttgcgca cccgtgcagg tatcgagttt     7980

aacggtatca gccgtcgccg ttatctggcg ctgctgaaag atatccaggc cccaattact     8040

ttgatttacg gtgatcagtc tgagttcaat cgcccagcag acctgcaagc gatccaggcg     8100

gcactgccgc aagcgcaacg cctgacggtt gctggcggtc acaacttgca ctttgagaat     8160

ccgcaggcca tcgcccagat tgtctatcag cagttgcaga caccggttcc gaaaacccaa     8220

ggtttgcacc atcaccacca tcatagcgcc tggagccacc cgcagtttga aaagtaa        8277


<210> 27
<211> 8277
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
atggcaagct ggtcccaccc gcaattcgag aaagaagtac atcaccatca ccatcatggc       60

gcagtgggcc agtttgcgaa ctttgtagac ctgttgcaat accgtgccaa gctgcaagca      120

cgtaagaccg tctttagctt cctggcggac ggcgaagcgg agagcgccgc tctgacctat      180

ggtgagctgg atcaaaaggc gcaggcaatc gcggcgttcc tgcaagcaaa tcaggcacaa      240

ggccaacgtg cattgctgct gtatccgcca ggtctggagt tcatcggtgc cttcctgggt      300

tgtctgtatg cgggtgtcgt cgcggttccg gcatatcctc cgcgtccgaa caagtccttc      360

gaccgtttgc actccatcat tcaggacgcc caagcgaagt ttgcactgac gacgaccgag      420

ttgaaggata agattgcaga ccgtctggaa gcgctggagg gtacggactt ccattgcctg      480

gcgaccgacc aagtcgagct gatcagcggc aaaaactggc aaaagccgaa tatctccggt      540

acggatctgg cgtttctgca atacaccagc ggcagcacgg gtgatccaaa aggcgtgatg      600

gtcagccacc ataacctgat tcacaatagc ggtctgattt tcacctcttt tcacatgaac      660

gatgaaacta tcattttctc gtggctgccg ccacatcacg atatgggttt gattggctgc      720

attctgaccc cgatttacgg tggtattcag gctatcatga tgagcccgtt tagctttttg      780

cagaacccgc tgtcctggct gaaacatatc actaagtaca aagcgaccat ttctggtagc      840

ccgaactttg cgtacgacta ttgcgttaaa cgcattcgcg aagaaaagaa agagggtctg      900

gatctgtcta gctgggttac cgcgttcaat ggtgcagagc cgattcgcgc tgtcacgctg      960

gaaaactttg cgaaaacgtt cgcaaccgcg ggtttccaga aatcggcctt ctacccttgt     1020

tacggtatgg cggaaaccac cctgatcgtg agcggtggca atggccgtgc ccaactgcca     1080

caggagatca tcgttagcaa gcagggcatt gaggcgaacc aagtgcgtcc ggctcaaggc     1140

acggaaacga ccgtgaccct ggtgggtagc ggtgaggtca ttggtgacca gatcgttaag     1200

atcgttgacc ctcaagcgct gaccgagtgc accgtcggtg aaattggcga ggtgtgggtt     1260

aaaggtgaaa gcgttgctca gggctactgg cagaagccgg acttgacgca gcagcagttc     1320

cagggtaacg tgggtgccga aacgggtttc ctgcgcaccg gcgatctggg tttcctgcaa     1380

ggcggcgagc tgtatatcac cggccgtctg aaggatctgc tgatcattcg tggccgtaat     1440

cactatcctc aggacattga gctgaccgtg gaagttgctc acccagccct gcgtcagggc     1500

gcaggtgccg cggtgagcgt ggacgttaat ggtgaagaac aactggtgat cgttcaagag     1560

gttgagcgta agtacgcacg caagctgaat gtggcagcag tcgctcaggc catccgtggt     1620

gcgattgcgg cagagcacca gttgcagccg caggcgatct gctttatcaa accgggcagc     1680

atcccgaaaa ctagcagcgg caaaatccgt cgtcacgcat gtaaggccgg ttttctggac     1740

ggaagcttgg cggttgttgg tgagtggcaa ccgagccatc agaaagaggg caaaggtatt     1800

ggtacccagg cagtgacccc gagcaccacg acgtccacca actttccgct gccggatcaa     1860

caccagcaac agatcgaggc gtggctgaag gacaacatcg cgcaccgcct gggtattacg     1920

ccgcagcagt tggatgaaac ggaaccgttc gcttcttacg gtctggacag cgttcaagca     1980

gtccaggtca ccgcagacct ggaggactgg ctgggccgca agctggaccc gactctggcc     2040

tatgattacc cgaccattcg cacgctggcg caattcctgg ttcagggcaa ccaggccttg     2100

gagaaaatcc cgcaagttcc aaagattcag ggtaaagaga ttgcggtggt gggcctgagc     2160

tgccgctttc cgcaggcgga caatccggag gcgttctggg aactgttgcg caatggcaag     2220

gatggcgtgc gtccgctgaa aacccgttgg gccactggtg agtggggtgg tttcctggag     2280

gatatcgacc agtttgagcc gcagttcttt ggtattagcc cgcgtgaggc ggagcaaatg     2340

gacccgcaac agcgtctgct gctggaggtc acctgggagg cactggagcg tgcgaatatc     2400

cctgccgaat ccctgcgtca cagccagacc ggcgtctttg tgggcattag caacagcgat     2460

tacgcacaac tgcaagtgcg tgagaacaac ccgatcaatc cgtacatggg tactggtaac     2520

gcacatagca tcgcggcgaa tcgtctgagc tactttctgg atctgcgcgg tgtctccctg     2580

agcattgata ccgcgtgttc tagcagcctg gtcgcagttc atctggcgtg ccaaagcctg     2640

attaacggcg agagcgagct ggcgattgct gcgggtgtta atctgattct gaccccggat     2700

gtcacgcaaa cctttaccca agcgggtatg atgagcaaga cgggccgttg ccagacgttt     2760

gatgcggagg cggacggcta cgtgcgcggt gaaggctgcg gcgttgttct gctgaaaccg     2820

ctggctcagg cggagcgtga tggcgacaat atcctggcgg tcatccacgg tagcgcggtt     2880

aaccaggacg gtcgcagcaa tggtctgact gcgccgaacg gccgctctca gcaagcggtt     2940

atccgtcagg ccctggcgca ggcgggcatc accgcggcag acctggcgta tttggaagcg     3000

catggtacgg gcaccccgct gggcgacccg attgaaatca acagcttgaa agcagtgctg     3060

caaaccgccc agcgcgagca accgtgcgtt gtgggcagcg tcaagacgaa cattggccac     3120

ctggaggcag cagcgggtat tgcaggtctg atcaaggtga ttctgtccct ggagcacggc     3180

atgattccgc aacacctgca ctttaagcaa ctgaatccgc gcatcgacct ggacggcctg     3240

gttaccatcg cgagcaaaga ccagccgtgg tcgggtggta gccagaagcg tttcgccggt     3300

gtcagcagct ttggttttgg cggtacgaat gctcacgtga ttgttggtga ttatgcccag     3360

caaaagtccc cgctggctcc gcctgcgacc caagaccgtc cttggcatct gctgactctg     3420

agcgcgaaga acgcacaagc gttgaacgcg ttgcaaaaga gctatggtga ctacctggcg     3480

caacatccga gcgttgaccc tcgcgatctg tgcctgagcg ctaacactgg tcgctctccg     3540

ctgaaagaac gccgcttctt cgtgttcaag caggttgccg acttgcaaca aaccctgaat     3600

caggactttc tggcgcagcc gaggctgagc agcccagcca agattgcgtt cctgttcacg     3660

ggtcagggca gccagtacta cggtatgggc cagcaactgt atcagacgtc cccggttttc     3720

cgtcaagtcc tggatgaatg cgaccgtctg tggcagacgt acagcccgga ggcaccggcg     3780

ctgaccgatc tgctgtacgg caatcataat cctgacctgg ttcatgaaac ggtttacacg     3840

caaccgctgc tgttcgcggt ggagtatgct atcgcgcagt tgtggttgag ctggggcgtt     3900

actccggatt tctgcatggg tcatagcgtc ggtgagtatg tggcggcctg cctggcgggt     3960

gtgtttagcc tggcggatgg catgaaactg attaccgcgc gtggtaaact gatgcatgca     4020

ctgccgagca atggcagcat ggcggctgtg tttgcggaca aaaccgttat caagccgtat     4080

ctgagcgaac acctgaccgt cggcgcagaa aatggcagcc acctggttct gagcggtaag     4140

accccttgtc tggaagcatc catccacaaa ctgcaaagcc agggcatcaa aaccaagcct     4200

ctgaaagtct cccatgcgtt ccactcgccg ctgatggcgc cgatgctggc ggaatttcgt     4260

gagatcgccg aacagattac gttccatccg ccacgtatcc cgctgattag caacgtgacg     4320

ggtggtcaaa tcgaggccga gatcgcgcaa gcagactatt gggttaaaca tgttagccag     4380

ccggtgaagt tcgttcagag cattcagacc ctggcccaag cgggtgtgaa tgtgtacctg     4440

gaaatcggtg ttaaaccagt cctgctgtct atgggtcgcc actgtctggc agagcaggaa     4500

gcggtttggc tgccgagcct gcgtccacat agcgagcctt ggccggaaat cttgactagt     4560

ctgggcaaac tgtacgagca aggtctgaat atcgactggc aaacggttga agccggtgat     4620

cgccgtcgta agctgatttt gccgacctac ccgttccagc gtcagcgtta ttggttcaac     4680

caaggtagct ggcaaaccgt cgaaactgag agcgtgaatc caggcccgga cgacctgaat     4740

gactggctgt accaagtggc atggactccg ctggatacgc tgccgcctgc accggaaccg     4800

tcggcgaaac tgtggctgat tctgggtgat cgtcacgatc accaaccgat tgaggcccag     4860

ttcaaaaacg cccaacgtgt gtacctgggc caaagcaacc actttccgac gaacgccccg     4920

tgggaggtga gcgcggacgc actggataac ttgtttaccc atgtgggtag ccaaaacctg     4980

gcaggcattc tgtatctgtg cccgcctggt gaagatccgg aggatctgga tgagattcag     5040

aaacaaactt ccggctttgc gttgcaactg attcagaccc tgtatcagca gaaaatcgca     5100

gtgccgtgtt ggtttgttac ccatcaaagc cagcgtgtgc tggaaacgga cgcggtgacg     5160

ggttttgccc aaggtggtct gtggggtttg gcgcaagcga ttgcactgga acatccggaa     5220

ctgtggggtg gtatcattga cgtggatgat agcctgccga acttcgcgca gatttgtcag     5280

caacgtcagg ttcagcaact ggctgtccgt caccagaaac tgtatggtgc gcaactgaag     5340

aagcagccga gcctgccgca gaagaatctg cagatccaac ctcaacagac ctacctggtc     5400

acgggcggtt tgggtgcaat cggtcgtaag attgcgcagt ggctggcggc tgcgggtgct     5460

gagaaagtta tcctggttag ccgtcgtgca ccggcagcgg atcaacaaac cttgccgacc     5520

aacgccgtgg tgtacccgtg cgatctggcg gatgcggcgc aggttgcgaa actgttccaa     5580

acctatccgc acattaaggg tatctttcat gcagccggta cgctggctga cggtttgctg     5640

caacagcaaa cctggcagaa attccagact gtcgctgcgg cgaagatgaa gggcacctgg     5700

cacctgcatc gccactctca gaagttggac ttggatttct ttgttttgtt ttcgtctgtt     5760

gcgggtgtgc tgggtagccc tggtcaaggc aattacgcgg cagccaaccg tggcatggcc     5820

gccatcgctc agtaccgcca ggctcaaggt ctgccggcac tggcgattca ctggggccct     5880

tgggcggaag gtggtatggc aaacagcttg agcaaccaaa atctggcatg gttgcctccg     5940

ccgcagggct tgaccattct ggaaaaagtt ttgggtgccc aaggcgaaat gggcgtgttc     6000

aaaccggact ggcagaactt ggccaaacaa ttcccggagt tcgcgaaaac ccattacttt     6060

gcggcggtca ttccgagcgc tgaagcggtt ccaccgaccg catctatctt cgacaagctg     6120

atcaatctgg aagcgagcca gcgcgcagat tacctgctgg actatctgcg tagatctgtg     6180

gcacaaattc tgaaactgga aattgagcag attcagagcc acgactccct gctggatctg     6240

ggtatggata gcctgatgat catggaggcg attgcgtccc tgaaacaaga cctgcaactg     6300

atgctgtatc cgcgtgagat ttacgagcgt ccgcgtctgg atgttctgac tgcttacttg     6360

gccgctgagt ttaccaaagc gcatgattct gaagcagcta ccgccgcagc tgcgatccct     6420

agccagagcc tgagcgtcaa aaccaaaaag caatggcaga aaccggatca taagaacccg     6480

aatccgattg cgttcatcct gagcagcccg cgtagcggta gcaccctgct gcgcgtgatg     6540

ctggccggtc acccgggtct gtattcccca ccggaactgc acctgctgcc gtttgaaacg     6600

atgggtgacc gccaccagga actgggtctg tctcatctgg gcgagggtct gcaacgtgcc     6660

ctgatggact tggaaaatct gacgccggaa gcatcccagg caaaggtgaa ccaatgggtg     6720

aaggcgaata cgccgattgc agacatctac gcatacctgc aacgtcaagc cgagcaacgt     6780

ctgctgattg acaaaagccc gagctatggc agcgaccgcc acattctgga tcacagcgag     6840

atcctgttcg atcaggcgaa atacatccac ctggttcgcc atccttatgc ggtcattgag     6900

agctttaccc gcctgcgtat ggacaagctg ctgggtgcag agcaacagaa tccgtatgcg     6960

ctggcggaaa gcatttggcg tacctcgaat cgcaacattc tggacttggg tcgtaccgtc     7020

ggcgctgacc gctacctgca agtcatctac gaggatctgg tgcgtgaccc gcgtaaagtt     7080

ctgaccaaca tttgtgattt tctgggtgtc gatttcgacg aggcactgct gaatccgtac     7140

tccggcgacc gcctgaccga cggcctgcac cagcaaagca tgggtgtggg tgacccgaac     7200

ttcttgcagc acaagaccat tgatccggcg ctagcggaca aatggcgtag cattaccctg     7260

ccggctgctc tgcaactgga tacgattcaa ctggccgaaa ccttcgcata cgacctgccg     7320

caggagccgc agttgacgcc gcagacccaa tctttgccat cgatggtcga acgtttcgtc     7380

acggttcgcg gcctggaaac ctgtctgtgc gagtggggtg atcgccatca acctctggtc     7440

ttgctgttgc acggtatcct ggagcaaggc gcgtcttggc agttgatcgc gcctcaactg     7500

gcagcgcagg gctattgggt cgtcgctccg gatctgcgcg gtcacggtaa atctgcgcac     7560

gcgcagtctt atagcatgct ggattttctg gccgatgtgg acgcgctggc caaacagttg     7620

ggcgaccgtc cgttcacctt ggttggtcac agcatgggtt ccatcattgg cgcaatgtat     7680

gctggcattc gtcaaaccca ggttgaaaaa ctgattctgg tcgaaaccat cgtcccgaat     7740

gatattgatg atgccgaaac cggcaatcac ctgaccaccc atctggatta cctggcagcc     7800

cctccgcagc acccgatctt tccgagcctg gaagttgcgg ctcgtcgtct gcgccaagcc     7860

accccgcagt tgccgaaaga cctgtctgca tttctgacgc aacgttccac gaagagcgtc     7920

gagaagggtg tgcagtggcg ctgggatgcc ttcttgcgca cccgtgcagg tatcgagttt     7980

aacggtatca gccgtcgccg ttatctggcg ctgctgaaag atatccaggc cccaattact     8040

ttgatttacg gtgatcagtc tgagttcaat cgcccagcag acctgcaagc gatccaggcg     8100

gcactgccgc aagcgcaacg cctgacggtt gctggcggtc acaacttgca ctttgagaat     8160

ccgcaggcca tcgcccagat tgtctatcag cagttgcaga caccggttcc gaaaacccaa     8220

ggtttgcacc atcaccacca tcatagcgcc tggagccacc cgcagtttga aaagtaa        8277


<210> 28
<211> 8277
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
atggcaagct ggtcccaccc gcaattcgag aaagaagtac atcaccatca ccatcatggc       60

gcagtgggcc agtttgcgaa ctttgtagac ctgttgcaat accgtgccaa gctgcaagca      120

cgtaagaccg tctttagctt cctggcggac ggcgaagcgg agagcgccgc tctgacctat      180

ggtgagctgg atcaaaaggc gcaggcaatc gcggcgttcc tgcaagcaaa tcaggcacaa      240

ggccaacgtg cattgctgct gtatccgcca ggtctggagt tcatcggtgc cttcctgggt      300

tgtctgtatg cgggtgtcgt cgcggttccg gcatatcctc cgcgtccgaa caagtccttc      360

gaccgtttgc actccatcat tcaggacgcc caagcgaagt ttgcactgac gacgaccgag      420

ttgaaggata agattgcaga ccgtctggaa gcgctggagg gtacggactt ccattgcctg      480

gcgaccgacc aagtcgagct gatcagcggc aaaaactggc aaaagccgaa tatctccggt      540

acggatctgg cgtttctgca atacaccagc ggcagcacgg gtgatccaaa aggcgtgatg      600

gtcagccacc ataacctgat tcacaatagc ggtctgattc gcaacgcgct ggcgattgat      660

ctgaaagata ccctgctgtc ttggatgccg ttgactcacg atatgggttt gattgcgtgc      720

catctggttc cggcgctggc gggcattaac cagaatttga tgccgactga actgttcatt      780

cgtcgcccga ttctgtggat gaagaaagct cacgaacata aagcgtctat tctgtctagc      840

ccgaatttcg gttacaacta ctttctgaaa ttcctgaaag acaacaaaag ctacgattgg      900

gatctgtccc atattcgcgt tatcgcgaac ggtgcagagc cgattcgcgc tgtcacgctg      960

gaaaactttg cgaaaacgtt cgcaaccgcg ggtttccaga aatcggcctt ctacccttgt     1020

tacggtatgg cggaaaccac cctgatcgtg agcggtggca atggccgtgc ccaactgcca     1080

caggagatca tcgttagcaa gcagggcatt gaggcgaacc aagtgcgtcc ggctcaaggc     1140

acggaaacga ccgtgaccct ggtgggtagc ggtgaggtca ttggtgacca gatcgttaag     1200

atcgttgacc ctcaagcgct gaccgagtgc accgtcggtg aaattggcga ggtgtgggtt     1260

aaaggtgaaa gcgttgctca gggctactgg cagaagccgg acttgacgca gcagcagttc     1320

cagggtaacg tgggtgccga aacgggtttc ctgcgcaccg gcgatctggg tttcctgcaa     1380

ggcggcgagc tgtatatcac cggccgtctg aaggatctgc tgatcattcg tggccgtaat     1440

cactatcctc aggacattga gctgaccgtg gaagttgctc acccagccct gcgtcagggc     1500

gcaggtgccg cggtgagcgt ggacgttaat ggtgaagaac aactggtgat cgttcaagag     1560

gttgagcgta agtacgcacg caagctgaat gtggcagcag tcgctcaggc catccgtggt     1620

gcgattgcgg cagagcacca gttgcagccg caggcgatct gctttatcaa accgggcagc     1680

atcccgaaaa ctagcagcgg caaaatccgt cgtcacgcat gtaaggccgg ttttctggac     1740

ggaagcttgg cggttgttgg tgagtggcaa ccgagccatc agaaagaggg caaaggtatt     1800

ggtacccagg cagtgacccc gagcaccacg acgtccacca actttccgct gccggatcaa     1860

caccagcaac agatcgaggc gtggctgaag gacaacatcg cgcaccgcct gggtattacg     1920

ccgcagcagt tggatgaaac ggaaccgttc gcttcttacg gtctggacag cgttcaagca     1980

gtccaggtca ccgcagacct ggaggactgg ctgggccgca agctggaccc gactctggcc     2040

tatgattacc cgaccattcg cacgctggcg caattcctgg ttcagggcaa ccaggccttg     2100

gagaaaatcc cgcaagttcc aaagattcag ggtaaagaga ttgcggtggt gggcctgagc     2160

tgccgctttc cgcaggcgga caatccggag gcgttctggg aactgttgcg caatggcaag     2220

gatggcgtgc gtccgctgaa aacccgttgg gccactggtg agtggggtgg tttcctggag     2280

gatatcgacc agtttgagcc gcagttcttt ggtattagcc cgcgtgaggc ggagcaaatg     2340

gacccgcaac agcgtctgct gctggaggtc acctgggagg cactggagcg tgcgaatatc     2400

cctgccgaat ccctgcgtca cagccagacc ggcgtctttg tgggcattag caacagcgat     2460

tacgcacaac tgcaagtgcg tgagaacaac ccgatcaatc cgtacatggg tactggtaac     2520

gcacatagca tcgcggcgaa tcgtctgagc tactttctgg atctgcgcgg tgtctccctg     2580

agcattgata ccgcgtgttc tagcagcctg gtcgcagttc atctggcgtg ccaaagcctg     2640

attaacggcg agagcgagct ggcgattgct gcgggtgtta atctgattct gaccccggat     2700

gtcacgcaaa cctttaccca agcgggtatg atgagcaaga cgggccgttg ccagacgttt     2760

gatgcggagg cggacggcta cgtgcgcggt gaaggctgcg gcgttgttct gctgaaaccg     2820

ctggctcagg cggagcgtga tggcgacaat atcctggcgg tcatccacgg tagcgcggtt     2880

aaccaggacg gtcgcagcaa tggtctgact gcgccgaacg gccgctctca gcaagcggtt     2940

atccgtcagg ccctggcgca ggcgggcatc accgcggcag acctggcgta tttggaagcg     3000

catggtacgg gcaccccgct gggcgacccg attgaaatca acagcttgaa agcagtgctg     3060

caaaccgccc agcgcgagca accgtgcgtt gtgggcagcg tcaagacgaa cattggccac     3120

ctggaggcag cagcgggtat tgcaggtctg atcaaggtga ttctgtccct ggagcacggc     3180

atgattccgc aacacctgca ctttaagcaa ctgaatccgc gcatcgacct ggacggcctg     3240

gttaccatcg cgagcaaaga ccagccgtgg tcgggtggta gccagaagcg tttcgccggt     3300

gtcagcagct ttggttttgg cggtacgaat gctcacgtga ttgttggtga ttatgcccag     3360

caaaagtccc cgctggctcc gcctgcgacc caagaccgtc cttggcatct gctgactctg     3420

agcgcgaaga acgcacaagc gttgaacgcg ttgcaaaaga gctatggtga ctacctggcg     3480

caacatccga gcgttgaccc tcgcgatctg tgcctgagcg ctaacactgg tcgctctccg     3540

ctgaaagaac gccgcttctt cgtgttcaag caggttgccg acttgcaaca aaccctgaat     3600

caggactttc tggcgcagcc gaggctgagc agcccagcca agattgcgtt cctgttcacg     3660

ggtcagggca gccagtacta cggtatgggc cagcaactgt atcagacgtc cccggttttc     3720

cgtcaagtcc tggatgaatg cgaccgtctg tggcagacgt acagcccgga ggcaccggcg     3780

ctgaccgatc tgctgtacgg caatcataat cctgacctgg ttcatgaaac ggtttacacg     3840

caaccgctgc tgttcgcggt ggagtatgct atcgcgcagt tgtggttgag ctggggcgtt     3900

actccggatt tctgcatggg tcatagcgtc ggtgagtatg tggcggcctg cctggcgggt     3960

gtgtttagcc tggcggatgg catgaaactg attaccgcgc gtggtaaact gatgcatgca     4020

ctgccgagca atggcagcat ggcggctgtg tttgcggaca aaaccgttat caagccgtat     4080

ctgagcgaac acctgaccgt cggcgcagaa aatggcagcc acctggttct gagcggtaag     4140

accccttgtc tggaagcatc catccacaaa ctgcaaagcc agggcatcaa aaccaagcct     4200

ctgaaagtct cccatgcgtt ccactcgccg ctgatggcgc cgatgctggc ggaatttcgt     4260

gagatcgccg aacagattac gttccatccg ccacgtatcc cgctgattag caacgtgacg     4320

ggtggtcaaa tcgaggccga gatcgcgcaa gcagactatt gggttaaaca tgttagccag     4380

ccggtgaagt tcgttcagag cattcagacc ctggcccaag cgggtgtgaa tgtgtacctg     4440

gaaatcggtg ttaaaccagt cctgctgtct atgggtcgcc actgtctggc agagcaggaa     4500

gcggtttggc tgccgagcct gcgtccacat agcgagcctt ggccggaaat cttgactagt     4560

ctgggcaaac tgtacgagca aggtctgaat atcgactggc aaacggttga agccggtgat     4620

cgccgtcgta agctgatttt gccgacctac ccgttccagc gtcagcgtta ttggttcaac     4680

caaggtagct ggcaaaccgt cgaaactgag agcgtgaatc caggcccgga cgacctgaat     4740

gactggctgt accaagtggc atggactccg ctggatacgc tgccgcctgc accggaaccg     4800

tcggcgaaac tgtggctgat tctgggtgat cgtcacgatc accaaccgat tgaggcccag     4860

ttcaaaaacg cccaacgtgt gtacctgggc caaagcaacc actttccgac gaacgccccg     4920

tgggaggtga gcgcggacgc actggataac ttgtttaccc atgtgggtag ccaaaacctg     4980

gcaggcattc tgtatctgtg cccgcctggt gaagatccgg aggatctgga tgagattcag     5040

aaacaaactt ccggctttgc gttgcaactg attcagaccc tgtatcagca gaaaatcgca     5100

gtgccgtgtt ggtttgttac ccatcaaagc cagcgtgtgc tggaaacgga cgcggtgacg     5160

ggttttgccc aaggtggtct gtggggtttg gcgcaagcga ttgcactgga acatccggaa     5220

ctgtggggtg gtatcattga cgtggatgat agcctgccga acttcgcgca gatttgtcag     5280

caacgtcagg ttcagcaact ggctgtccgt caccagaaac tgtatggtgc gcaactgaag     5340

aagcagccga gcctgccgca gaagaatctg cagatccaac ctcaacagac ctacctggtc     5400

acgggcggtt tgggtgcaat cggtcgtaag attgcgcagt ggctggcggc tgcgggtgct     5460

gagaaagtta tcctggttag ccgtcgtgca ccggcagcgg atcaacaaac cttgccgacc     5520

aacgccgtgg tgtacccgtg cgatctggcg gatgcggcgc aggttgcgaa actgttccaa     5580

acctatccgc acattaaggg tatctttcat gcagccggta cgctggctga cggtttgctg     5640

caacagcaaa cctggcagaa attccagact gtcgctgcgg cgaagatgaa gggcacctgg     5700

cacctgcatc gccactctca gaagttggac ttggatttct ttgttttgtt ttcgtctgtt     5760

gcgggtgtgc tgggtagccc tggtcaaggc aattacgcgg cagccaaccg tggcatggcc     5820

gccatcgctc agtaccgcca ggctcaaggt ctgccggcac tggcgattca ctggggccct     5880

tgggcggaag gtggtatggc aaacagcttg agcaaccaaa atctggcatg gttgcctccg     5940

ccgcagggct tgaccattct ggaaaaagtt ttgggtgccc aaggcgaaat gggcgtgttc     6000

aaaccggact ggcagaactt ggccaaacaa ttcccggagt tcgcgaaaac ccattacttt     6060

gcggcggtca ttccgagcgc tgaagcggtt ccaccgaccg catctatctt cgacaagctg     6120

atcaatctgg aagcgagcca gcgcgcagat tacctgctgg actatctgcg tagatctgtg     6180

gcacaaattc tgaaactgga aattgagcag attcagagcc acgactccct gctggatctg     6240

ggtatggata gcctgatgat catggaggcg attgcgtccc tgaaacaaga cctgcaactg     6300

atgctgtatc cgcgtgagat ttacgagcgt ccgcgtctgg atgttctgac tgcttacttg     6360

gccgctgagt ttaccaaagc gcatgattct gaagcagcta ccgccgcagc tgcgatccct     6420

agccagagcc tgagcgtcaa aaccaaaaag caatggcaga aaccggatca taagaacccg     6480

aatccgattg cgttcatcct gagcagcccg cgtagcggta gcaccctgct gcgcgtgatg     6540

ctggccggtc acccgggtct gtattcccca ccggaactgc acctgctgcc gtttgaaacg     6600

atgggtgacc gccaccagga actgggtctg tctcatctgg gcgagggtct gcaacgtgcc     6660

ctgatggact tggaaaatct gacgccggaa gcatcccagg caaaggtgaa ccaatgggtg     6720

aaggcgaata cgccgattgc agacatctac gcatacctgc aacgtcaagc cgagcaacgt     6780

ctgctgattg acaaaagccc gagctatggc agcgaccgcc acattctgga tcacagcgag     6840

atcctgttcg atcaggcgaa atacatccac ctggttcgcc atccttatgc ggtcattgag     6900

agctttaccc gcctgcgtat ggacaagctg ctgggtgcag agcaacagaa tccgtatgcg     6960

ctggcggaaa gcatttggcg tacctcgaat cgcaacattc tggacttggg tcgtaccgtc     7020

ggcgctgacc gctacctgca agtcatctac gaggatctgg tgcgtgaccc gcgtaaagtt     7080

ctgaccaaca tttgtgattt tctgggtgtc gatttcgacg aggcactgct gaatccgtac     7140

tccggcgacc gcctgaccga cggcctgcac cagcaaagca tgggtgtggg tgacccgaac     7200

ttcttgcagc acaagaccat tgatccggcg ctagcggaca aatggcgtag cattaccctg     7260

ccggctgctc tgcaactgga tacgattcaa ctggccgaaa ccttcgcata cgacctgccg     7320

caggagccgc agttgacgcc gcagacccaa tctttgccat cgatggtcga acgtttcgtc     7380

acggttcgcg gcctggaaac ctgtctgtgc gagtggggtg atcgccatca acctctggtc     7440

ttgctgttgc acggtatcct ggagcaaggc gcgtcttggc agttgatcgc gcctcaactg     7500

gcagcgcagg gctattgggt cgtcgctccg gatctgcgcg gtcacggtaa atctgcgcac     7560

gcgcagtctt atagcatgct ggattttctg gccgatgtgg acgcgctggc caaacagttg     7620

ggcgaccgtc cgttcacctt ggttggtcac agcatgggtt ccatcattgg cgcaatgtat     7680

gctggcattc gtcaaaccca ggttgaaaaa ctgattctgg tcgaaaccat cgtcccgaat     7740

gatattgatg atgccgaaac cggcaatcac ctgaccaccc atctggatta cctggcagcc     7800

cctccgcagc acccgatctt tccgagcctg gaagttgcgg ctcgtcgtct gcgccaagcc     7860

accccgcagt tgccgaaaga cctgtctgca tttctgacgc aacgttccac gaagagcgtc     7920

gagaagggtg tgcagtggcg ctgggatgcc ttcttgcgca cccgtgcagg tatcgagttt     7980

aacggtatca gccgtcgccg ttatctggcg ctgctgaaag atatccaggc cccaattact     8040

ttgatttacg gtgatcagtc tgagttcaat cgcccagcag acctgcaagc gatccaggcg     8100

gcactgccgc aagcgcaacg cctgacggtt gctggcggtc acaacttgca ctttgagaat     8160

ccgcaggcca tcgcccagat tgtctatcag cagttgcaga caccggttcc gaaaacccaa     8220

ggtttgcacc atcaccacca tcatagcgcc tggagccacc cgcagtttga aaagtaa        8277


<210> 29
<211> 2758
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Ala Ser Trp Ser His Pro Gln Phe Glu Lys Glu Val His His His 
1               5                   10                  15      


His His His Gly Ala Val Gly Gln Phe Ala Asn Phe Val Asp Leu Leu 
            20                  25                  30          


Gln Tyr Arg Ala Lys Leu Gln Ala Arg Lys Thr Val Phe Ser Phe Leu 
        35                  40                  45              


Ala Asp Gly Glu Ala Glu Ser Ala Ala Leu Thr Tyr Gly Glu Leu Asp 
    50                  55                  60                  


Gln Lys Ala Gln Ala Ile Ala Ala Phe Leu Gln Ala Asn Gln Ala Gln 
65                  70                  75                  80  


Gly Gln Arg Ala Leu Leu Leu Tyr Pro Pro Gly Leu Glu Phe Ile Gly 
                85                  90                  95      


Ala Phe Leu Gly Cys Leu Tyr Ala Gly Val Val Ala Val Pro Ala Tyr 
            100                 105                 110         


Pro Pro Arg Pro Asn Lys Ser Phe Asp Arg Leu His Ser Ile Ile Gln 
        115                 120                 125             


Asp Ala Gln Ala Lys Phe Ala Leu Thr Thr Thr Glu Leu Lys Asp Lys 
    130                 135                 140                 


Ile Ala Asp Arg Leu Glu Ala Leu Glu Gly Thr Asp Phe His Cys Leu 
145                 150                 155                 160 


Ala Thr Asp Gln Val Glu Leu Ile Ser Gly Lys Asn Trp Gln Lys Pro 
                165                 170                 175     


Asn Ile Ser Gly Thr Asp Leu Ala Phe Leu Gln Tyr Thr Ser Gly Ser 
            180                 185                 190         


Thr Gly Asp Pro Lys Gly Val Met Val Ser His His Asn Leu Ile His 
        195                 200                 205             


Asn Ser Gly Leu Leu Ala Glu Ala Cys Glu Leu Thr Ala Ala Thr Pro 
    210                 215                 220                 


Met Gly Gly Trp Leu Pro Met Tyr His Asp Met Gly Leu Leu Gly Thr 
225                 230                 235                 240 


Leu Thr Pro Ala Leu Tyr Leu Gly Thr Thr Cys Val Leu Met Ser Ser 
                245                 250                 255     


Thr Ala Phe Ile Lys Arg Pro His Leu Trp Leu Arg Thr Ile Asp Arg 
            260                 265                 270         


Phe Gly Leu Val Trp Ser Ser Ala Pro Asp Phe Ala Tyr Asp Met Cys 
        275                 280                 285             


Leu Lys Arg Val Thr Asp Glu Gln Ile Ala Gly Leu Asp Leu Ser Arg 
    290                 295                 300                 


Trp Arg Trp Ala Gly Asn Gly Ala Glu Pro Ile Arg Ala Val Thr Leu 
305                 310                 315                 320 


Glu Asn Phe Ala Lys Thr Phe Ala Thr Ala Gly Phe Gln Lys Ser Ala 
                325                 330                 335     


Phe Tyr Pro Cys Tyr Gly Met Ala Glu Thr Thr Leu Ile Val Ser Gly 
            340                 345                 350         


Gly Asn Gly Arg Ala Gln Leu Pro Gln Glu Ile Ile Val Ser Lys Gln 
        355                 360                 365             


Gly Ile Glu Ala Asn Gln Val Arg Pro Ala Gln Gly Thr Glu Thr Thr 
    370                 375                 380                 


Val Thr Leu Val Gly Ser Gly Glu Val Ile Gly Asp Gln Ile Val Lys 
385                 390                 395                 400 


Ile Val Asp Pro Gln Ala Leu Thr Glu Cys Thr Val Gly Glu Ile Gly 
                405                 410                 415     


Glu Val Trp Val Lys Gly Glu Ser Val Ala Gln Gly Tyr Trp Gln Lys 
            420                 425                 430         


Pro Asp Leu Thr Gln Gln Gln Phe Gln Gly Asn Val Gly Ala Glu Thr 
        435                 440                 445             


Gly Phe Leu Arg Thr Gly Asp Leu Gly Phe Leu Gln Gly Gly Glu Leu 
    450                 455                 460                 


Tyr Ile Thr Gly Arg Leu Lys Asp Leu Leu Ile Ile Arg Gly Arg Asn 
465                 470                 475                 480 


His Tyr Pro Gln Asp Ile Glu Leu Thr Val Glu Val Ala His Pro Ala 
                485                 490                 495     


Leu Arg Gln Gly Ala Gly Ala Ala Val Ser Val Asp Val Asn Gly Glu 
            500                 505                 510         


Glu Gln Leu Val Ile Val Gln Glu Val Glu Arg Lys Tyr Ala Arg Lys 
        515                 520                 525             


Leu Asn Val Ala Ala Val Ala Gln Ala Ile Arg Gly Ala Ile Ala Ala 
    530                 535                 540                 


Glu His Gln Leu Gln Pro Gln Ala Ile Cys Phe Ile Lys Pro Gly Ser 
545                 550                 555                 560 


Ile Pro Lys Thr Ser Ser Gly Lys Ile Arg Arg His Ala Cys Lys Ala 
                565                 570                 575     


Gly Phe Leu Asp Gly Ser Leu Ala Val Val Gly Glu Trp Gln Pro Ser 
            580                 585                 590         


His Gln Lys Glu Gly Lys Gly Ile Gly Thr Gln Ala Val Thr Pro Ser 
        595                 600                 605             


Thr Thr Thr Ser Thr Asn Phe Pro Leu Pro Asp Gln His Gln Gln Gln 
    610                 615                 620                 


Ile Glu Ala Trp Leu Lys Asp Asn Ile Ala His Arg Leu Gly Ile Thr 
625                 630                 635                 640 


Pro Gln Gln Leu Asp Glu Thr Glu Pro Phe Ala Ser Tyr Gly Leu Asp 
                645                 650                 655     


Ser Val Gln Ala Val Gln Val Thr Ala Asp Leu Glu Asp Trp Leu Gly 
            660                 665                 670         


Arg Lys Leu Asp Pro Thr Leu Ala Tyr Asp Tyr Pro Thr Ile Arg Thr 
        675                 680                 685             


Leu Ala Gln Phe Leu Val Gln Gly Asn Gln Ala Leu Glu Lys Ile Pro 
    690                 695                 700                 


Gln Val Pro Lys Ile Gln Gly Lys Glu Ile Ala Val Val Gly Leu Ser 
705                 710                 715                 720 


Cys Arg Phe Pro Gln Ala Asp Asn Pro Glu Ala Phe Trp Glu Leu Leu 
                725                 730                 735     


Arg Asn Gly Lys Asp Gly Val Arg Pro Leu Lys Thr Arg Trp Ala Thr 
            740                 745                 750         


Gly Glu Trp Gly Gly Phe Leu Glu Asp Ile Asp Gln Phe Glu Pro Gln 
        755                 760                 765             


Phe Phe Gly Ile Ser Pro Arg Glu Ala Glu Gln Met Asp Pro Gln Gln 
    770                 775                 780                 


Arg Leu Leu Leu Glu Val Thr Trp Glu Ala Leu Glu Arg Ala Asn Ile 
785                 790                 795                 800 


Pro Ala Glu Ser Leu Arg His Ser Gln Thr Gly Val Phe Val Gly Ile 
                805                 810                 815     


Ser Asn Ser Asp Tyr Ala Gln Leu Gln Val Arg Glu Asn Asn Pro Ile 
            820                 825                 830         


Asn Pro Tyr Met Gly Thr Gly Asn Ala His Ser Ile Ala Ala Asn Arg 
        835                 840                 845             


Leu Ser Tyr Phe Leu Asp Leu Arg Gly Val Ser Leu Ser Ile Asp Thr 
    850                 855                 860                 


Ala Cys Ser Ser Ser Leu Val Ala Val His Leu Ala Cys Gln Ser Leu 
865                 870                 875                 880 


Ile Asn Gly Glu Ser Glu Leu Ala Ile Ala Ala Gly Val Asn Leu Ile 
                885                 890                 895     


Leu Thr Pro Asp Val Thr Gln Thr Phe Thr Gln Ala Gly Met Met Ser 
            900                 905                 910         


Lys Thr Gly Arg Cys Gln Thr Phe Asp Ala Glu Ala Asp Gly Tyr Val 
        915                 920                 925             


Arg Gly Glu Gly Cys Gly Val Val Leu Leu Lys Pro Leu Ala Gln Ala 
    930                 935                 940                 


Glu Arg Asp Gly Asp Asn Ile Leu Ala Val Ile His Gly Ser Ala Val 
945                 950                 955                 960 


Asn Gln Asp Gly Arg Ser Asn Gly Leu Thr Ala Pro Asn Gly Arg Ser 
                965                 970                 975     


Gln Gln Ala Val Ile Arg Gln Ala Leu Ala Gln Ala Gly Ile Thr Ala 
            980                 985                 990         


Ala Asp Leu Ala Tyr Leu Glu Ala  His Gly Thr Gly Thr  Pro Leu Gly 
        995                 1000                 1005             


Asp Pro  Ile Glu Ile Asn Ser  Leu Lys Ala Val Leu  Gln Thr Ala 
    1010                 1015                 1020             


Gln Arg  Glu Gln Pro Cys Val  Val Gly Ser Val Lys  Thr Asn Ile 
    1025                 1030                 1035             


Gly His  Leu Glu Ala Ala Ala  Gly Ile Ala Gly Leu  Ile Lys Val 
    1040                 1045                 1050             


Ile Leu  Ser Leu Glu His Gly  Met Ile Pro Gln His  Leu His Phe 
    1055                 1060                 1065             


Lys Gln  Leu Asn Pro Arg Ile  Asp Leu Asp Gly Leu  Val Thr Ile 
    1070                 1075                 1080             


Ala Ser  Lys Asp Gln Pro Trp  Ser Gly Gly Ser Gln  Lys Arg Phe 
    1085                 1090                 1095             


Ala Gly  Val Ser Ser Phe Gly  Phe Gly Gly Thr Asn  Ala His Val 
    1100                 1105                 1110             


Ile Val  Gly Asp Tyr Ala Gln  Gln Lys Ser Pro Leu  Ala Pro Pro 
    1115                 1120                 1125             


Ala Thr  Gln Asp Arg Pro Trp  His Leu Leu Thr Leu  Ser Ala Lys 
    1130                 1135                 1140             


Asn Ala  Gln Ala Leu Asn Ala  Leu Gln Lys Ser Tyr  Gly Asp Tyr 
    1145                 1150                 1155             


Leu Ala  Gln His Pro Ser Val  Asp Pro Arg Asp Leu  Cys Leu Ser 
    1160                 1165                 1170             


Ala Asn  Thr Gly Arg Ser Pro  Leu Lys Glu Arg Arg  Phe Phe Val 
    1175                 1180                 1185             


Phe Lys  Gln Val Ala Asp Leu  Gln Gln Thr Leu Asn  Gln Asp Phe 
    1190                 1195                 1200             


Leu Ala  Gln Pro Arg Leu Ser  Ser Pro Ala Lys Ile  Ala Phe Leu 
    1205                 1210                 1215             


Phe Thr  Gly Gln Gly Ser Gln  Tyr Tyr Gly Met Gly  Gln Gln Leu 
    1220                 1225                 1230             


Tyr Gln  Thr Ser Pro Val Phe  Arg Gln Val Leu Asp  Glu Cys Asp 
    1235                 1240                 1245             


Arg Leu  Trp Gln Thr Tyr Ser  Pro Glu Ala Pro Ala  Leu Thr Asp 
    1250                 1255                 1260             


Leu Leu  Tyr Gly Asn His Asn  Pro Asp Leu Val His  Glu Thr Val 
    1265                 1270                 1275             


Tyr Thr  Gln Pro Leu Leu Phe  Ala Val Glu Tyr Ala  Ile Ala Gln 
    1280                 1285                 1290             


Leu Trp  Leu Ser Trp Gly Val  Thr Pro Asp Phe Cys  Met Gly His 
    1295                 1300                 1305             


Ser Val  Gly Glu Tyr Val Ala  Ala Cys Leu Ala Gly  Val Phe Ser 
    1310                 1315                 1320             


Leu Ala  Asp Gly Met Lys Leu  Ile Thr Ala Arg Gly  Lys Leu Met 
    1325                 1330                 1335             


His Ala  Leu Pro Ser Asn Gly  Ser Met Ala Ala Val  Phe Ala Asp 
    1340                 1345                 1350             


Lys Thr  Val Ile Lys Pro Tyr  Leu Ser Glu His Leu  Thr Val Gly 
    1355                 1360                 1365             


Ala Glu  Asn Gly Ser His Leu  Val Leu Ser Gly Lys  Thr Pro Cys 
    1370                 1375                 1380             


Leu Glu  Ala Ser Ile His Lys  Leu Gln Ser Gln Gly  Ile Lys Thr 
    1385                 1390                 1395             


Lys Pro  Leu Lys Val Ser His  Ala Phe His Ser Pro  Leu Met Ala 
    1400                 1405                 1410             


Pro Met  Leu Ala Glu Phe Arg  Glu Ile Ala Glu Gln  Ile Thr Phe 
    1415                 1420                 1425             


His Pro  Pro Arg Ile Pro Leu  Ile Ser Asn Val Thr  Gly Gly Gln 
    1430                 1435                 1440             


Ile Glu  Ala Glu Ile Ala Gln  Ala Asp Tyr Trp Val  Lys His Val 
    1445                 1450                 1455             


Ser Gln  Pro Val Lys Phe Val  Gln Ser Ile Gln Thr  Leu Ala Gln 
    1460                 1465                 1470             


Ala Gly  Val Asn Val Tyr Leu  Glu Ile Gly Val Lys  Pro Val Leu 
    1475                 1480                 1485             


Leu Ser  Met Gly Arg His Cys  Leu Ala Glu Gln Glu  Ala Val Trp 
    1490                 1495                 1500             


Leu Pro  Ser Leu Arg Pro His  Ser Glu Pro Trp Pro  Glu Ile Leu 
    1505                 1510                 1515             


Thr Ser  Leu Gly Lys Leu Tyr  Glu Gln Gly Leu Asn  Ile Asp Trp 
    1520                 1525                 1530             


Gln Thr  Val Glu Ala Gly Asp  Arg Arg Arg Lys Leu  Ile Leu Pro 
    1535                 1540                 1545             


Thr Tyr  Pro Phe Gln Arg Gln  Arg Tyr Trp Phe Asn  Gln Gly Ser 
    1550                 1555                 1560             


Trp Gln  Thr Val Glu Thr Glu  Ser Val Asn Pro Gly  Pro Asp Asp 
    1565                 1570                 1575             


Leu Asn  Asp Trp Leu Tyr Gln  Val Ala Trp Thr Pro  Leu Asp Thr 
    1580                 1585                 1590             


Leu Pro  Pro Ala Pro Glu Pro  Ser Ala Lys Leu Trp  Leu Ile Leu 
    1595                 1600                 1605             


Gly Asp  Arg His Asp His Gln  Pro Ile Glu Ala Gln  Phe Lys Asn 
    1610                 1615                 1620             


Ala Gln  Arg Val Tyr Leu Gly  Gln Ser Asn His Phe  Pro Thr Asn 
    1625                 1630                 1635             


Ala Pro  Trp Glu Val Ser Ala  Asp Ala Leu Asp Asn  Leu Phe Thr 
    1640                 1645                 1650             


His Val  Gly Ser Gln Asn Leu  Ala Gly Ile Leu Tyr  Leu Cys Pro 
    1655                 1660                 1665             


Pro Gly  Glu Asp Pro Glu Asp  Leu Asp Glu Ile Gln  Lys Gln Thr 
    1670                 1675                 1680             


Ser Gly  Phe Ala Leu Gln Leu  Ile Gln Thr Leu Tyr  Gln Gln Lys 
    1685                 1690                 1695             


Ile Ala  Val Pro Cys Trp Phe  Val Thr His Gln Ser  Gln Arg Val 
    1700                 1705                 1710             


Leu Glu  Thr Asp Ala Val Thr  Gly Phe Ala Gln Gly  Gly Leu Trp 
    1715                 1720                 1725             


Gly Leu  Ala Gln Ala Ile Ala  Leu Glu His Pro Glu  Leu Trp Gly 
    1730                 1735                 1740             


Gly Ile  Ile Asp Val Asp Asp  Ser Leu Pro Asn Phe  Ala Gln Ile 
    1745                 1750                 1755             


Cys Gln  Gln Arg Gln Val Gln  Gln Leu Ala Val Arg  His Gln Lys 
    1760                 1765                 1770             


Leu Tyr  Gly Ala Gln Leu Lys  Lys Gln Pro Ser Leu  Pro Gln Lys 
    1775                 1780                 1785             


Asn Leu  Gln Ile Gln Pro Gln  Gln Thr Tyr Leu Val  Thr Gly Gly 
    1790                 1795                 1800             


Leu Gly  Ala Ile Gly Arg Lys  Ile Ala Gln Trp Leu  Ala Ala Ala 
    1805                 1810                 1815             


Gly Ala  Glu Lys Val Ile Leu  Val Ser Arg Arg Ala  Pro Ala Ala 
    1820                 1825                 1830             


Asp Gln  Gln Thr Leu Pro Thr  Asn Ala Val Val Tyr  Pro Cys Asp 
    1835                 1840                 1845             


Leu Ala  Asp Ala Ala Gln Val  Ala Lys Leu Phe Gln  Thr Tyr Pro 
    1850                 1855                 1860             


His Ile  Lys Gly Ile Phe His  Ala Ala Gly Thr Leu  Ala Asp Gly 
    1865                 1870                 1875             


Leu Leu  Gln Gln Gln Thr Trp  Gln Lys Phe Gln Thr  Val Ala Ala 
    1880                 1885                 1890             


Ala Lys  Met Lys Gly Thr Trp  His Leu His Arg His  Ser Gln Lys 
    1895                 1900                 1905             


Leu Asp  Leu Asp Phe Phe Val  Leu Phe Ser Ser Val  Ala Gly Val 
    1910                 1915                 1920             


Leu Gly  Ser Pro Gly Gln Gly  Asn Tyr Ala Ala Ala  Asn Arg Gly 
    1925                 1930                 1935             


Met Ala  Ala Ile Ala Gln Tyr  Arg Gln Ala Gln Gly  Leu Pro Ala 
    1940                 1945                 1950             


Leu Ala  Ile His Trp Gly Pro  Trp Ala Glu Gly Gly  Met Ala Asn 
    1955                 1960                 1965             


Ser Leu  Ser Asn Gln Asn Leu  Ala Trp Leu Pro Pro  Pro Gln Gly 
    1970                 1975                 1980             


Leu Thr  Ile Leu Glu Lys Val  Leu Gly Ala Gln Gly  Glu Met Gly 
    1985                 1990                 1995             


Val Phe  Lys Pro Asp Trp Gln  Asn Leu Ala Lys Gln  Phe Pro Glu 
    2000                 2005                 2010             


Phe Ala  Lys Thr His Tyr Phe  Ala Ala Val Ile Pro  Ser Ala Glu 
    2015                 2020                 2025             


Ala Val  Pro Pro Thr Ala Ser  Ile Phe Asp Lys Leu  Ile Asn Leu 
    2030                 2035                 2040             


Glu Ala  Ser Gln Arg Ala Asp  Tyr Leu Leu Asp Tyr  Leu Arg Arg 
    2045                 2050                 2055             


Ser Val  Ala Gln Ile Leu Lys  Leu Glu Ile Glu Gln  Ile Gln Ser 
    2060                 2065                 2070             


His Asp  Ser Leu Leu Asp Leu  Gly Met Asp Ser Leu  Met Ile Met 
    2075                 2080                 2085             


Glu Ala  Ile Ala Ser Leu Lys  Gln Asp Leu Gln Leu  Met Leu Tyr 
    2090                 2095                 2100             


Pro Arg  Glu Ile Tyr Glu Arg  Pro Arg Leu Asp Val  Leu Thr Ala 
    2105                 2110                 2115             


Tyr Leu  Ala Ala Glu Phe Thr  Lys Ala His Asp Ser  Glu Ala Ala 
    2120                 2125                 2130             


Thr Ala  Ala Ala Ala Ile Pro  Ser Gln Ser Leu Ser  Val Lys Thr 
    2135                 2140                 2145             


Lys Lys  Gln Trp Gln Lys Pro  Asp His Lys Asn Pro  Asn Pro Ile 
    2150                 2155                 2160             


Ala Phe  Ile Leu Ser Ser Pro  Arg Ser Gly Ser Thr  Leu Leu Arg 
    2165                 2170                 2175             


Val Met  Leu Ala Gly His Pro  Gly Leu Tyr Ser Pro  Pro Glu Leu 
    2180                 2185                 2190             


His Leu  Leu Pro Phe Glu Thr  Met Gly Asp Arg His  Gln Glu Leu 
    2195                 2200                 2205             


Gly Leu  Ser His Leu Gly Glu  Gly Leu Gln Arg Ala  Leu Met Asp 
    2210                 2215                 2220             


Leu Glu  Asn Leu Thr Pro Glu  Ala Ser Gln Ala Lys  Val Asn Gln 
    2225                 2230                 2235             


Trp Val  Lys Ala Asn Thr Pro  Ile Ala Asp Ile Tyr  Ala Tyr Leu 
    2240                 2245                 2250             


Gln Arg  Gln Ala Glu Gln Arg  Leu Leu Ile Asp Lys  Ser Pro Ser 
    2255                 2260                 2265             


Tyr Gly  Ser Asp Arg His Ile  Leu Asp His Ser Glu  Ile Leu Phe 
    2270                 2275                 2280             


Asp Gln  Ala Lys Tyr Ile His  Leu Val Arg His Pro  Tyr Ala Val 
    2285                 2290                 2295             


Ile Glu  Ser Phe Thr Arg Leu  Arg Met Asp Lys Leu  Leu Gly Ala 
    2300                 2305                 2310             


Glu Gln  Gln Asn Pro Tyr Ala  Leu Ala Glu Ser Ile  Trp Arg Thr 
    2315                 2320                 2325             


Ser Asn  Arg Asn Ile Leu Asp  Leu Gly Arg Thr Val  Gly Ala Asp 
    2330                 2335                 2340             


Arg Tyr  Leu Gln Val Ile Tyr  Glu Asp Leu Val Arg  Asp Pro Arg 
    2345                 2350                 2355             


Lys Val  Leu Thr Asn Ile Cys  Asp Phe Leu Gly Val  Asp Phe Asp 
    2360                 2365                 2370             


Glu Ala  Leu Leu Asn Pro Tyr  Ser Gly Asp Arg Leu  Thr Asp Gly 
    2375                 2380                 2385             


Leu His  Gln Gln Ser Met Gly  Val Gly Asp Pro Asn  Phe Leu Gln 
    2390                 2395                 2400             


His Lys  Thr Ile Asp Pro Ala  Leu Ala Asp Lys Trp  Arg Ser Ile 
    2405                 2410                 2415             


Thr Leu  Pro Ala Ala Leu Gln  Leu Asp Thr Ile Gln  Leu Ala Glu 
    2420                 2425                 2430             


Thr Phe  Ala Tyr Asp Leu Pro  Gln Glu Pro Gln Leu  Thr Pro Gln 
    2435                 2440                 2445             


Thr Gln  Ser Leu Pro Ser Met  Val Glu Arg Phe Val  Thr Val Arg 
    2450                 2455                 2460             


Gly Leu  Glu Thr Cys Leu Cys  Glu Trp Gly Asp Arg  His Gln Pro 
    2465                 2470                 2475             


Leu Val  Leu Leu Leu His Gly  Ile Leu Glu Gln Gly  Ala Ser Trp 
    2480                 2485                 2490             


Gln Leu  Ile Ala Pro Gln Leu  Ala Ala Gln Gly Tyr  Trp Val Val 
    2495                 2500                 2505             


Ala Pro  Asp Leu Arg Gly His  Gly Lys Ser Ala His  Ala Gln Ser 
    2510                 2515                 2520             


Tyr Ser  Met Leu Asp Phe Leu  Ala Asp Val Asp Ala  Leu Ala Lys 
    2525                 2530                 2535             


Gln Leu  Gly Asp Arg Pro Phe  Thr Leu Val Gly His  Ser Met Gly 
    2540                 2545                 2550             


Ser Ile  Ile Gly Ala Met Tyr  Ala Gly Ile Arg Gln  Thr Gln Val 
    2555                 2560                 2565             


Glu Lys  Leu Ile Leu Val Glu  Thr Ile Val Pro Asn  Asp Ile Asp 
    2570                 2575                 2580             


Asp Ala  Glu Thr Gly Asn His  Leu Thr Thr His Leu  Asp Tyr Leu 
    2585                 2590                 2595             


Ala Ala  Pro Pro Gln His Pro  Ile Phe Pro Ser Leu  Glu Val Ala 
    2600                 2605                 2610             


Ala Arg  Arg Leu Arg Gln Ala  Thr Pro Gln Leu Pro  Lys Asp Leu 
    2615                 2620                 2625             


Ser Ala  Phe Leu Thr Gln Arg  Ser Thr Lys Ser Val  Glu Lys Gly 
    2630                 2635                 2640             


Val Gln  Trp Arg Trp Asp Ala  Phe Leu Arg Thr Arg  Ala Gly Ile 
    2645                 2650                 2655             


Glu Phe  Asn Gly Ile Ser Arg  Arg Arg Tyr Leu Ala  Leu Leu Lys 
    2660                 2665                 2670             


Asp Ile  Gln Ala Pro Ile Thr  Leu Ile Tyr Gly Asp  Gln Ser Glu 
    2675                 2680                 2685             


Phe Asn  Arg Pro Ala Asp Leu  Gln Ala Ile Gln Ala  Ala Leu Pro 
    2690                 2695                 2700             


Gln Ala  Gln Arg Leu Thr Val  Ala Gly Gly His Asn  Leu His Phe 
    2705                 2710                 2715             


Glu Asn  Pro Gln Ala Ile Ala  Gln Ile Val Tyr Gln  Gln Leu Gln 
    2720                 2725                 2730             


Thr Pro  Val Pro Lys Thr Gln  Gly Leu His His His  His His His 
    2735                 2740                 2745             


Ser Ala  Trp Ser His Pro Gln  Phe Glu Lys 
    2750                 2755             


<210> 30
<211> 2758
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Ala Ser Trp Ser His Pro Gln Phe Glu Lys Glu Val His His His 
1               5                   10                  15      


His His His Gly Ala Val Gly Gln Phe Ala Asn Phe Val Asp Leu Leu 
            20                  25                  30          


Gln Tyr Arg Ala Lys Leu Gln Ala Arg Lys Thr Val Phe Ser Phe Leu 
        35                  40                  45              


Ala Asp Gly Glu Ala Glu Ser Ala Ala Leu Thr Tyr Gly Glu Leu Asp 
    50                  55                  60                  


Gln Lys Ala Gln Ala Ile Ala Ala Phe Leu Gln Ala Asn Gln Ala Gln 
65                  70                  75                  80  


Gly Gln Arg Ala Leu Leu Leu Tyr Pro Pro Gly Leu Glu Phe Ile Gly 
                85                  90                  95      


Ala Phe Leu Gly Cys Leu Tyr Ala Gly Val Val Ala Val Pro Ala Tyr 
            100                 105                 110         


Pro Pro Arg Pro Asn Lys Ser Phe Asp Arg Leu His Ser Ile Ile Gln 
        115                 120                 125             


Asp Ala Gln Ala Lys Phe Ala Leu Thr Thr Thr Glu Leu Lys Asp Lys 
    130                 135                 140                 


Ile Ala Asp Arg Leu Glu Ala Leu Glu Gly Thr Asp Phe His Cys Leu 
145                 150                 155                 160 


Ala Thr Asp Gln Val Glu Leu Ile Ser Gly Lys Asn Trp Gln Lys Pro 
                165                 170                 175     


Asn Ile Ser Gly Thr Asp Leu Ala Phe Leu Gln Tyr Thr Ser Gly Ser 
            180                 185                 190         


Thr Gly Asp Pro Lys Gly Val Met Val Ser His His Asn Leu Ile His 
        195                 200                 205             


Asn Ser Gly Leu Ile Phe Thr Ser Phe His Met Asn Asp Glu Thr Ile 
    210                 215                 220                 


Ile Phe Ser Trp Leu Pro Pro His His Asp Met Gly Leu Ile Gly Cys 
225                 230                 235                 240 


Ile Leu Thr Pro Ile Tyr Gly Gly Ile Gln Ala Ile Met Met Ser Pro 
                245                 250                 255     


Phe Ser Phe Leu Gln Asn Pro Leu Ser Trp Leu Lys His Ile Thr Lys 
            260                 265                 270         


Tyr Lys Ala Thr Ile Ser Gly Ser Pro Asn Phe Ala Tyr Asp Tyr Cys 
        275                 280                 285             


Val Lys Arg Ile Arg Glu Glu Lys Lys Glu Gly Leu Asp Leu Ser Ser 
    290                 295                 300                 


Trp Val Thr Ala Phe Asn Gly Ala Glu Pro Ile Arg Ala Val Thr Leu 
305                 310                 315                 320 


Glu Asn Phe Ala Lys Thr Phe Ala Thr Ala Gly Phe Gln Lys Ser Ala 
                325                 330                 335     


Phe Tyr Pro Cys Tyr Gly Met Ala Glu Thr Thr Leu Ile Val Ser Gly 
            340                 345                 350         


Gly Asn Gly Arg Ala Gln Leu Pro Gln Glu Ile Ile Val Ser Lys Gln 
        355                 360                 365             


Gly Ile Glu Ala Asn Gln Val Arg Pro Ala Gln Gly Thr Glu Thr Thr 
    370                 375                 380                 


Val Thr Leu Val Gly Ser Gly Glu Val Ile Gly Asp Gln Ile Val Lys 
385                 390                 395                 400 


Ile Val Asp Pro Gln Ala Leu Thr Glu Cys Thr Val Gly Glu Ile Gly 
                405                 410                 415     


Glu Val Trp Val Lys Gly Glu Ser Val Ala Gln Gly Tyr Trp Gln Lys 
            420                 425                 430         


Pro Asp Leu Thr Gln Gln Gln Phe Gln Gly Asn Val Gly Ala Glu Thr 
        435                 440                 445             


Gly Phe Leu Arg Thr Gly Asp Leu Gly Phe Leu Gln Gly Gly Glu Leu 
    450                 455                 460                 


Tyr Ile Thr Gly Arg Leu Lys Asp Leu Leu Ile Ile Arg Gly Arg Asn 
465                 470                 475                 480 


His Tyr Pro Gln Asp Ile Glu Leu Thr Val Glu Val Ala His Pro Ala 
                485                 490                 495     


Leu Arg Gln Gly Ala Gly Ala Ala Val Ser Val Asp Val Asn Gly Glu 
            500                 505                 510         


Glu Gln Leu Val Ile Val Gln Glu Val Glu Arg Lys Tyr Ala Arg Lys 
        515                 520                 525             


Leu Asn Val Ala Ala Val Ala Gln Ala Ile Arg Gly Ala Ile Ala Ala 
    530                 535                 540                 


Glu His Gln Leu Gln Pro Gln Ala Ile Cys Phe Ile Lys Pro Gly Ser 
545                 550                 555                 560 


Ile Pro Lys Thr Ser Ser Gly Lys Ile Arg Arg His Ala Cys Lys Ala 
                565                 570                 575     


Gly Phe Leu Asp Gly Ser Leu Ala Val Val Gly Glu Trp Gln Pro Ser 
            580                 585                 590         


His Gln Lys Glu Gly Lys Gly Ile Gly Thr Gln Ala Val Thr Pro Ser 
        595                 600                 605             


Thr Thr Thr Ser Thr Asn Phe Pro Leu Pro Asp Gln His Gln Gln Gln 
    610                 615                 620                 


Ile Glu Ala Trp Leu Lys Asp Asn Ile Ala His Arg Leu Gly Ile Thr 
625                 630                 635                 640 


Pro Gln Gln Leu Asp Glu Thr Glu Pro Phe Ala Ser Tyr Gly Leu Asp 
                645                 650                 655     


Ser Val Gln Ala Val Gln Val Thr Ala Asp Leu Glu Asp Trp Leu Gly 
            660                 665                 670         


Arg Lys Leu Asp Pro Thr Leu Ala Tyr Asp Tyr Pro Thr Ile Arg Thr 
        675                 680                 685             


Leu Ala Gln Phe Leu Val Gln Gly Asn Gln Ala Leu Glu Lys Ile Pro 
    690                 695                 700                 


Gln Val Pro Lys Ile Gln Gly Lys Glu Ile Ala Val Val Gly Leu Ser 
705                 710                 715                 720 


Cys Arg Phe Pro Gln Ala Asp Asn Pro Glu Ala Phe Trp Glu Leu Leu 
                725                 730                 735     


Arg Asn Gly Lys Asp Gly Val Arg Pro Leu Lys Thr Arg Trp Ala Thr 
            740                 745                 750         


Gly Glu Trp Gly Gly Phe Leu Glu Asp Ile Asp Gln Phe Glu Pro Gln 
        755                 760                 765             


Phe Phe Gly Ile Ser Pro Arg Glu Ala Glu Gln Met Asp Pro Gln Gln 
    770                 775                 780                 


Arg Leu Leu Leu Glu Val Thr Trp Glu Ala Leu Glu Arg Ala Asn Ile 
785                 790                 795                 800 


Pro Ala Glu Ser Leu Arg His Ser Gln Thr Gly Val Phe Val Gly Ile 
                805                 810                 815     


Ser Asn Ser Asp Tyr Ala Gln Leu Gln Val Arg Glu Asn Asn Pro Ile 
            820                 825                 830         


Asn Pro Tyr Met Gly Thr Gly Asn Ala His Ser Ile Ala Ala Asn Arg 
        835                 840                 845             


Leu Ser Tyr Phe Leu Asp Leu Arg Gly Val Ser Leu Ser Ile Asp Thr 
    850                 855                 860                 


Ala Cys Ser Ser Ser Leu Val Ala Val His Leu Ala Cys Gln Ser Leu 
865                 870                 875                 880 


Ile Asn Gly Glu Ser Glu Leu Ala Ile Ala Ala Gly Val Asn Leu Ile 
                885                 890                 895     


Leu Thr Pro Asp Val Thr Gln Thr Phe Thr Gln Ala Gly Met Met Ser 
            900                 905                 910         


Lys Thr Gly Arg Cys Gln Thr Phe Asp Ala Glu Ala Asp Gly Tyr Val 
        915                 920                 925             


Arg Gly Glu Gly Cys Gly Val Val Leu Leu Lys Pro Leu Ala Gln Ala 
    930                 935                 940                 


Glu Arg Asp Gly Asp Asn Ile Leu Ala Val Ile His Gly Ser Ala Val 
945                 950                 955                 960 


Asn Gln Asp Gly Arg Ser Asn Gly Leu Thr Ala Pro Asn Gly Arg Ser 
                965                 970                 975     


Gln Gln Ala Val Ile Arg Gln Ala Leu Ala Gln Ala Gly Ile Thr Ala 
            980                 985                 990         


Ala Asp Leu Ala Tyr Leu Glu Ala  His Gly Thr Gly Thr  Pro Leu Gly 
        995                 1000                 1005             


Asp Pro  Ile Glu Ile Asn Ser  Leu Lys Ala Val Leu  Gln Thr Ala 
    1010                 1015                 1020             


Gln Arg  Glu Gln Pro Cys Val  Val Gly Ser Val Lys  Thr Asn Ile 
    1025                 1030                 1035             


Gly His  Leu Glu Ala Ala Ala  Gly Ile Ala Gly Leu  Ile Lys Val 
    1040                 1045                 1050             


Ile Leu  Ser Leu Glu His Gly  Met Ile Pro Gln His  Leu His Phe 
    1055                 1060                 1065             


Lys Gln  Leu Asn Pro Arg Ile  Asp Leu Asp Gly Leu  Val Thr Ile 
    1070                 1075                 1080             


Ala Ser  Lys Asp Gln Pro Trp  Ser Gly Gly Ser Gln  Lys Arg Phe 
    1085                 1090                 1095             


Ala Gly  Val Ser Ser Phe Gly  Phe Gly Gly Thr Asn  Ala His Val 
    1100                 1105                 1110             


Ile Val  Gly Asp Tyr Ala Gln  Gln Lys Ser Pro Leu  Ala Pro Pro 
    1115                 1120                 1125             


Ala Thr  Gln Asp Arg Pro Trp  His Leu Leu Thr Leu  Ser Ala Lys 
    1130                 1135                 1140             


Asn Ala  Gln Ala Leu Asn Ala  Leu Gln Lys Ser Tyr  Gly Asp Tyr 
    1145                 1150                 1155             


Leu Ala  Gln His Pro Ser Val  Asp Pro Arg Asp Leu  Cys Leu Ser 
    1160                 1165                 1170             


Ala Asn  Thr Gly Arg Ser Pro  Leu Lys Glu Arg Arg  Phe Phe Val 
    1175                 1180                 1185             


Phe Lys  Gln Val Ala Asp Leu  Gln Gln Thr Leu Asn  Gln Asp Phe 
    1190                 1195                 1200             


Leu Ala  Gln Pro Arg Leu Ser  Ser Pro Ala Lys Ile  Ala Phe Leu 
    1205                 1210                 1215             


Phe Thr  Gly Gln Gly Ser Gln  Tyr Tyr Gly Met Gly  Gln Gln Leu 
    1220                 1225                 1230             


Tyr Gln  Thr Ser Pro Val Phe  Arg Gln Val Leu Asp  Glu Cys Asp 
    1235                 1240                 1245             


Arg Leu  Trp Gln Thr Tyr Ser  Pro Glu Ala Pro Ala  Leu Thr Asp 
    1250                 1255                 1260             


Leu Leu  Tyr Gly Asn His Asn  Pro Asp Leu Val His  Glu Thr Val 
    1265                 1270                 1275             


Tyr Thr  Gln Pro Leu Leu Phe  Ala Val Glu Tyr Ala  Ile Ala Gln 
    1280                 1285                 1290             


Leu Trp  Leu Ser Trp Gly Val  Thr Pro Asp Phe Cys  Met Gly His 
    1295                 1300                 1305             


Ser Val  Gly Glu Tyr Val Ala  Ala Cys Leu Ala Gly  Val Phe Ser 
    1310                 1315                 1320             


Leu Ala  Asp Gly Met Lys Leu  Ile Thr Ala Arg Gly  Lys Leu Met 
    1325                 1330                 1335             


His Ala  Leu Pro Ser Asn Gly  Ser Met Ala Ala Val  Phe Ala Asp 
    1340                 1345                 1350             


Lys Thr  Val Ile Lys Pro Tyr  Leu Ser Glu His Leu  Thr Val Gly 
    1355                 1360                 1365             


Ala Glu  Asn Gly Ser His Leu  Val Leu Ser Gly Lys  Thr Pro Cys 
    1370                 1375                 1380             


Leu Glu  Ala Ser Ile His Lys  Leu Gln Ser Gln Gly  Ile Lys Thr 
    1385                 1390                 1395             


Lys Pro  Leu Lys Val Ser His  Ala Phe His Ser Pro  Leu Met Ala 
    1400                 1405                 1410             


Pro Met  Leu Ala Glu Phe Arg  Glu Ile Ala Glu Gln  Ile Thr Phe 
    1415                 1420                 1425             


His Pro  Pro Arg Ile Pro Leu  Ile Ser Asn Val Thr  Gly Gly Gln 
    1430                 1435                 1440             


Ile Glu  Ala Glu Ile Ala Gln  Ala Asp Tyr Trp Val  Lys His Val 
    1445                 1450                 1455             


Ser Gln  Pro Val Lys Phe Val  Gln Ser Ile Gln Thr  Leu Ala Gln 
    1460                 1465                 1470             


Ala Gly  Val Asn Val Tyr Leu  Glu Ile Gly Val Lys  Pro Val Leu 
    1475                 1480                 1485             


Leu Ser  Met Gly Arg His Cys  Leu Ala Glu Gln Glu  Ala Val Trp 
    1490                 1495                 1500             


Leu Pro  Ser Leu Arg Pro His  Ser Glu Pro Trp Pro  Glu Ile Leu 
    1505                 1510                 1515             


Thr Ser  Leu Gly Lys Leu Tyr  Glu Gln Gly Leu Asn  Ile Asp Trp 
    1520                 1525                 1530             


Gln Thr  Val Glu Ala Gly Asp  Arg Arg Arg Lys Leu  Ile Leu Pro 
    1535                 1540                 1545             


Thr Tyr  Pro Phe Gln Arg Gln  Arg Tyr Trp Phe Asn  Gln Gly Ser 
    1550                 1555                 1560             


Trp Gln  Thr Val Glu Thr Glu  Ser Val Asn Pro Gly  Pro Asp Asp 
    1565                 1570                 1575             


Leu Asn  Asp Trp Leu Tyr Gln  Val Ala Trp Thr Pro  Leu Asp Thr 
    1580                 1585                 1590             


Leu Pro  Pro Ala Pro Glu Pro  Ser Ala Lys Leu Trp  Leu Ile Leu 
    1595                 1600                 1605             


Gly Asp  Arg His Asp His Gln  Pro Ile Glu Ala Gln  Phe Lys Asn 
    1610                 1615                 1620             


Ala Gln  Arg Val Tyr Leu Gly  Gln Ser Asn His Phe  Pro Thr Asn 
    1625                 1630                 1635             


Ala Pro  Trp Glu Val Ser Ala  Asp Ala Leu Asp Asn  Leu Phe Thr 
    1640                 1645                 1650             


His Val  Gly Ser Gln Asn Leu  Ala Gly Ile Leu Tyr  Leu Cys Pro 
    1655                 1660                 1665             


Pro Gly  Glu Asp Pro Glu Asp  Leu Asp Glu Ile Gln  Lys Gln Thr 
    1670                 1675                 1680             


Ser Gly  Phe Ala Leu Gln Leu  Ile Gln Thr Leu Tyr  Gln Gln Lys 
    1685                 1690                 1695             


Ile Ala  Val Pro Cys Trp Phe  Val Thr His Gln Ser  Gln Arg Val 
    1700                 1705                 1710             


Leu Glu  Thr Asp Ala Val Thr  Gly Phe Ala Gln Gly  Gly Leu Trp 
    1715                 1720                 1725             


Gly Leu  Ala Gln Ala Ile Ala  Leu Glu His Pro Glu  Leu Trp Gly 
    1730                 1735                 1740             


Gly Ile  Ile Asp Val Asp Asp  Ser Leu Pro Asn Phe  Ala Gln Ile 
    1745                 1750                 1755             


Cys Gln  Gln Arg Gln Val Gln  Gln Leu Ala Val Arg  His Gln Lys 
    1760                 1765                 1770             


Leu Tyr  Gly Ala Gln Leu Lys  Lys Gln Pro Ser Leu  Pro Gln Lys 
    1775                 1780                 1785             


Asn Leu  Gln Ile Gln Pro Gln  Gln Thr Tyr Leu Val  Thr Gly Gly 
    1790                 1795                 1800             


Leu Gly  Ala Ile Gly Arg Lys  Ile Ala Gln Trp Leu  Ala Ala Ala 
    1805                 1810                 1815             


Gly Ala  Glu Lys Val Ile Leu  Val Ser Arg Arg Ala  Pro Ala Ala 
    1820                 1825                 1830             


Asp Gln  Gln Thr Leu Pro Thr  Asn Ala Val Val Tyr  Pro Cys Asp 
    1835                 1840                 1845             


Leu Ala  Asp Ala Ala Gln Val  Ala Lys Leu Phe Gln  Thr Tyr Pro 
    1850                 1855                 1860             


His Ile  Lys Gly Ile Phe His  Ala Ala Gly Thr Leu  Ala Asp Gly 
    1865                 1870                 1875             


Leu Leu  Gln Gln Gln Thr Trp  Gln Lys Phe Gln Thr  Val Ala Ala 
    1880                 1885                 1890             


Ala Lys  Met Lys Gly Thr Trp  His Leu His Arg His  Ser Gln Lys 
    1895                 1900                 1905             


Leu Asp  Leu Asp Phe Phe Val  Leu Phe Ser Ser Val  Ala Gly Val 
    1910                 1915                 1920             


Leu Gly  Ser Pro Gly Gln Gly  Asn Tyr Ala Ala Ala  Asn Arg Gly 
    1925                 1930                 1935             


Met Ala  Ala Ile Ala Gln Tyr  Arg Gln Ala Gln Gly  Leu Pro Ala 
    1940                 1945                 1950             


Leu Ala  Ile His Trp Gly Pro  Trp Ala Glu Gly Gly  Met Ala Asn 
    1955                 1960                 1965             


Ser Leu  Ser Asn Gln Asn Leu  Ala Trp Leu Pro Pro  Pro Gln Gly 
    1970                 1975                 1980             


Leu Thr  Ile Leu Glu Lys Val  Leu Gly Ala Gln Gly  Glu Met Gly 
    1985                 1990                 1995             


Val Phe  Lys Pro Asp Trp Gln  Asn Leu Ala Lys Gln  Phe Pro Glu 
    2000                 2005                 2010             


Phe Ala  Lys Thr His Tyr Phe  Ala Ala Val Ile Pro  Ser Ala Glu 
    2015                 2020                 2025             


Ala Val  Pro Pro Thr Ala Ser  Ile Phe Asp Lys Leu  Ile Asn Leu 
    2030                 2035                 2040             


Glu Ala  Ser Gln Arg Ala Asp  Tyr Leu Leu Asp Tyr  Leu Arg Arg 
    2045                 2050                 2055             


Ser Val  Ala Gln Ile Leu Lys  Leu Glu Ile Glu Gln  Ile Gln Ser 
    2060                 2065                 2070             


His Asp  Ser Leu Leu Asp Leu  Gly Met Asp Ser Leu  Met Ile Met 
    2075                 2080                 2085             


Glu Ala  Ile Ala Ser Leu Lys  Gln Asp Leu Gln Leu  Met Leu Tyr 
    2090                 2095                 2100             


Pro Arg  Glu Ile Tyr Glu Arg  Pro Arg Leu Asp Val  Leu Thr Ala 
    2105                 2110                 2115             


Tyr Leu  Ala Ala Glu Phe Thr  Lys Ala His Asp Ser  Glu Ala Ala 
    2120                 2125                 2130             


Thr Ala  Ala Ala Ala Ile Pro  Ser Gln Ser Leu Ser  Val Lys Thr 
    2135                 2140                 2145             


Lys Lys  Gln Trp Gln Lys Pro  Asp His Lys Asn Pro  Asn Pro Ile 
    2150                 2155                 2160             


Ala Phe  Ile Leu Ser Ser Pro  Arg Ser Gly Ser Thr  Leu Leu Arg 
    2165                 2170                 2175             


Val Met  Leu Ala Gly His Pro  Gly Leu Tyr Ser Pro  Pro Glu Leu 
    2180                 2185                 2190             


His Leu  Leu Pro Phe Glu Thr  Met Gly Asp Arg His  Gln Glu Leu 
    2195                 2200                 2205             


Gly Leu  Ser His Leu Gly Glu  Gly Leu Gln Arg Ala  Leu Met Asp 
    2210                 2215                 2220             


Leu Glu  Asn Leu Thr Pro Glu  Ala Ser Gln Ala Lys  Val Asn Gln 
    2225                 2230                 2235             


Trp Val  Lys Ala Asn Thr Pro  Ile Ala Asp Ile Tyr  Ala Tyr Leu 
    2240                 2245                 2250             


Gln Arg  Gln Ala Glu Gln Arg  Leu Leu Ile Asp Lys  Ser Pro Ser 
    2255                 2260                 2265             


Tyr Gly  Ser Asp Arg His Ile  Leu Asp His Ser Glu  Ile Leu Phe 
    2270                 2275                 2280             


Asp Gln  Ala Lys Tyr Ile His  Leu Val Arg His Pro  Tyr Ala Val 
    2285                 2290                 2295             


Ile Glu  Ser Phe Thr Arg Leu  Arg Met Asp Lys Leu  Leu Gly Ala 
    2300                 2305                 2310             


Glu Gln  Gln Asn Pro Tyr Ala  Leu Ala Glu Ser Ile  Trp Arg Thr 
    2315                 2320                 2325             


Ser Asn  Arg Asn Ile Leu Asp  Leu Gly Arg Thr Val  Gly Ala Asp 
    2330                 2335                 2340             


Arg Tyr  Leu Gln Val Ile Tyr  Glu Asp Leu Val Arg  Asp Pro Arg 
    2345                 2350                 2355             


Lys Val  Leu Thr Asn Ile Cys  Asp Phe Leu Gly Val  Asp Phe Asp 
    2360                 2365                 2370             


Glu Ala  Leu Leu Asn Pro Tyr  Ser Gly Asp Arg Leu  Thr Asp Gly 
    2375                 2380                 2385             


Leu His  Gln Gln Ser Met Gly  Val Gly Asp Pro Asn  Phe Leu Gln 
    2390                 2395                 2400             


His Lys  Thr Ile Asp Pro Ala  Leu Ala Asp Lys Trp  Arg Ser Ile 
    2405                 2410                 2415             


Thr Leu  Pro Ala Ala Leu Gln  Leu Asp Thr Ile Gln  Leu Ala Glu 
    2420                 2425                 2430             


Thr Phe  Ala Tyr Asp Leu Pro  Gln Glu Pro Gln Leu  Thr Pro Gln 
    2435                 2440                 2445             


Thr Gln  Ser Leu Pro Ser Met  Val Glu Arg Phe Val  Thr Val Arg 
    2450                 2455                 2460             


Gly Leu  Glu Thr Cys Leu Cys  Glu Trp Gly Asp Arg  His Gln Pro 
    2465                 2470                 2475             


Leu Val  Leu Leu Leu His Gly  Ile Leu Glu Gln Gly  Ala Ser Trp 
    2480                 2485                 2490             


Gln Leu  Ile Ala Pro Gln Leu  Ala Ala Gln Gly Tyr  Trp Val Val 
    2495                 2500                 2505             


Ala Pro  Asp Leu Arg Gly His  Gly Lys Ser Ala His  Ala Gln Ser 
    2510                 2515                 2520             


Tyr Ser  Met Leu Asp Phe Leu  Ala Asp Val Asp Ala  Leu Ala Lys 
    2525                 2530                 2535             


Gln Leu  Gly Asp Arg Pro Phe  Thr Leu Val Gly His  Ser Met Gly 
    2540                 2545                 2550             


Ser Ile  Ile Gly Ala Met Tyr  Ala Gly Ile Arg Gln  Thr Gln Val 
    2555                 2560                 2565             


Glu Lys  Leu Ile Leu Val Glu  Thr Ile Val Pro Asn  Asp Ile Asp 
    2570                 2575                 2580             


Asp Ala  Glu Thr Gly Asn His  Leu Thr Thr His Leu  Asp Tyr Leu 
    2585                 2590                 2595             


Ala Ala  Pro Pro Gln His Pro  Ile Phe Pro Ser Leu  Glu Val Ala 
    2600                 2605                 2610             


Ala Arg  Arg Leu Arg Gln Ala  Thr Pro Gln Leu Pro  Lys Asp Leu 
    2615                 2620                 2625             


Ser Ala  Phe Leu Thr Gln Arg  Ser Thr Lys Ser Val  Glu Lys Gly 
    2630                 2635                 2640             


Val Gln  Trp Arg Trp Asp Ala  Phe Leu Arg Thr Arg  Ala Gly Ile 
    2645                 2650                 2655             


Glu Phe  Asn Gly Ile Ser Arg  Arg Arg Tyr Leu Ala  Leu Leu Lys 
    2660                 2665                 2670             


Asp Ile  Gln Ala Pro Ile Thr  Leu Ile Tyr Gly Asp  Gln Ser Glu 
    2675                 2680                 2685             


Phe Asn  Arg Pro Ala Asp Leu  Gln Ala Ile Gln Ala  Ala Leu Pro 
    2690                 2695                 2700             


Gln Ala  Gln Arg Leu Thr Val  Ala Gly Gly His Asn  Leu His Phe 
    2705                 2710                 2715             


Glu Asn  Pro Gln Ala Ile Ala  Gln Ile Val Tyr Gln  Gln Leu Gln 
    2720                 2725                 2730             


Thr Pro  Val Pro Lys Thr Gln  Gly Leu His His His  His His His 
    2735                 2740                 2745             


Ser Ala  Trp Ser His Pro Gln  Phe Glu Lys 
    2750                 2755             


<210> 31
<211> 2758
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Ala Ser Trp Ser His Pro Gln Phe Glu Lys Glu Val His His His 
1               5                   10                  15      


His His His Gly Ala Val Gly Gln Phe Ala Asn Phe Val Asp Leu Leu 
            20                  25                  30          


Gln Tyr Arg Ala Lys Leu Gln Ala Arg Lys Thr Val Phe Ser Phe Leu 
        35                  40                  45              


Ala Asp Gly Glu Ala Glu Ser Ala Ala Leu Thr Tyr Gly Glu Leu Asp 
    50                  55                  60                  


Gln Lys Ala Gln Ala Ile Ala Ala Phe Leu Gln Ala Asn Gln Ala Gln 
65                  70                  75                  80  


Gly Gln Arg Ala Leu Leu Leu Tyr Pro Pro Gly Leu Glu Phe Ile Gly 
                85                  90                  95      


Ala Phe Leu Gly Cys Leu Tyr Ala Gly Val Val Ala Val Pro Ala Tyr 
            100                 105                 110         


Pro Pro Arg Pro Asn Lys Ser Phe Asp Arg Leu His Ser Ile Ile Gln 
        115                 120                 125             


Asp Ala Gln Ala Lys Phe Ala Leu Thr Thr Thr Glu Leu Lys Asp Lys 
    130                 135                 140                 


Ile Ala Asp Arg Leu Glu Ala Leu Glu Gly Thr Asp Phe His Cys Leu 
145                 150                 155                 160 


Ala Thr Asp Gln Val Glu Leu Ile Ser Gly Lys Asn Trp Gln Lys Pro 
                165                 170                 175     


Asn Ile Ser Gly Thr Asp Leu Ala Phe Leu Gln Tyr Thr Ser Gly Ser 
            180                 185                 190         


Thr Gly Asp Pro Lys Gly Val Met Val Ser His His Asn Leu Ile His 
        195                 200                 205             


Asn Ser Gly Leu Ile Arg Asn Ala Leu Ala Ile Asp Leu Lys Asp Thr 
    210                 215                 220                 


Leu Leu Ser Trp Met Pro Leu Thr His Asp Met Gly Leu Ile Ala Cys 
225                 230                 235                 240 


His Leu Val Pro Ala Leu Ala Gly Ile Asn Gln Asn Leu Met Pro Thr 
                245                 250                 255     


Glu Leu Phe Ile Arg Arg Pro Ile Leu Trp Met Lys Lys Ala His Glu 
            260                 265                 270         


His Lys Ala Ser Ile Leu Ser Ser Pro Asn Phe Gly Tyr Asn Tyr Phe 
        275                 280                 285             


Leu Lys Phe Leu Lys Asp Asn Lys Ser Tyr Asp Trp Asp Leu Ser His 
    290                 295                 300                 


Ile Arg Val Ile Ala Asn Gly Ala Glu Pro Ile Arg Ala Val Thr Leu 
305                 310                 315                 320 


Glu Asn Phe Ala Lys Thr Phe Ala Thr Ala Gly Phe Gln Lys Ser Ala 
                325                 330                 335     


Phe Tyr Pro Cys Tyr Gly Met Ala Glu Thr Thr Leu Ile Val Ser Gly 
            340                 345                 350         


Gly Asn Gly Arg Ala Gln Leu Pro Gln Glu Ile Ile Val Ser Lys Gln 
        355                 360                 365             


Gly Ile Glu Ala Asn Gln Val Arg Pro Ala Gln Gly Thr Glu Thr Thr 
    370                 375                 380                 


Val Thr Leu Val Gly Ser Gly Glu Val Ile Gly Asp Gln Ile Val Lys 
385                 390                 395                 400 


Ile Val Asp Pro Gln Ala Leu Thr Glu Cys Thr Val Gly Glu Ile Gly 
                405                 410                 415     


Glu Val Trp Val Lys Gly Glu Ser Val Ala Gln Gly Tyr Trp Gln Lys 
            420                 425                 430         


Pro Asp Leu Thr Gln Gln Gln Phe Gln Gly Asn Val Gly Ala Glu Thr 
        435                 440                 445             


Gly Phe Leu Arg Thr Gly Asp Leu Gly Phe Leu Gln Gly Gly Glu Leu 
    450                 455                 460                 


Tyr Ile Thr Gly Arg Leu Lys Asp Leu Leu Ile Ile Arg Gly Arg Asn 
465                 470                 475                 480 


His Tyr Pro Gln Asp Ile Glu Leu Thr Val Glu Val Ala His Pro Ala 
                485                 490                 495     


Leu Arg Gln Gly Ala Gly Ala Ala Val Ser Val Asp Val Asn Gly Glu 
            500                 505                 510         


Glu Gln Leu Val Ile Val Gln Glu Val Glu Arg Lys Tyr Ala Arg Lys 
        515                 520                 525             


Leu Asn Val Ala Ala Val Ala Gln Ala Ile Arg Gly Ala Ile Ala Ala 
    530                 535                 540                 


Glu His Gln Leu Gln Pro Gln Ala Ile Cys Phe Ile Lys Pro Gly Ser 
545                 550                 555                 560 


Ile Pro Lys Thr Ser Ser Gly Lys Ile Arg Arg His Ala Cys Lys Ala 
                565                 570                 575     


Gly Phe Leu Asp Gly Ser Leu Ala Val Val Gly Glu Trp Gln Pro Ser 
            580                 585                 590         


His Gln Lys Glu Gly Lys Gly Ile Gly Thr Gln Ala Val Thr Pro Ser 
        595                 600                 605             


Thr Thr Thr Ser Thr Asn Phe Pro Leu Pro Asp Gln His Gln Gln Gln 
    610                 615                 620                 


Ile Glu Ala Trp Leu Lys Asp Asn Ile Ala His Arg Leu Gly Ile Thr 
625                 630                 635                 640 


Pro Gln Gln Leu Asp Glu Thr Glu Pro Phe Ala Ser Tyr Gly Leu Asp 
                645                 650                 655     


Ser Val Gln Ala Val Gln Val Thr Ala Asp Leu Glu Asp Trp Leu Gly 
            660                 665                 670         


Arg Lys Leu Asp Pro Thr Leu Ala Tyr Asp Tyr Pro Thr Ile Arg Thr 
        675                 680                 685             


Leu Ala Gln Phe Leu Val Gln Gly Asn Gln Ala Leu Glu Lys Ile Pro 
    690                 695                 700                 


Gln Val Pro Lys Ile Gln Gly Lys Glu Ile Ala Val Val Gly Leu Ser 
705                 710                 715                 720 


Cys Arg Phe Pro Gln Ala Asp Asn Pro Glu Ala Phe Trp Glu Leu Leu 
                725                 730                 735     


Arg Asn Gly Lys Asp Gly Val Arg Pro Leu Lys Thr Arg Trp Ala Thr 
            740                 745                 750         


Gly Glu Trp Gly Gly Phe Leu Glu Asp Ile Asp Gln Phe Glu Pro Gln 
        755                 760                 765             


Phe Phe Gly Ile Ser Pro Arg Glu Ala Glu Gln Met Asp Pro Gln Gln 
    770                 775                 780                 


Arg Leu Leu Leu Glu Val Thr Trp Glu Ala Leu Glu Arg Ala Asn Ile 
785                 790                 795                 800 


Pro Ala Glu Ser Leu Arg His Ser Gln Thr Gly Val Phe Val Gly Ile 
                805                 810                 815     


Ser Asn Ser Asp Tyr Ala Gln Leu Gln Val Arg Glu Asn Asn Pro Ile 
            820                 825                 830         


Asn Pro Tyr Met Gly Thr Gly Asn Ala His Ser Ile Ala Ala Asn Arg 
        835                 840                 845             


Leu Ser Tyr Phe Leu Asp Leu Arg Gly Val Ser Leu Ser Ile Asp Thr 
    850                 855                 860                 


Ala Cys Ser Ser Ser Leu Val Ala Val His Leu Ala Cys Gln Ser Leu 
865                 870                 875                 880 


Ile Asn Gly Glu Ser Glu Leu Ala Ile Ala Ala Gly Val Asn Leu Ile 
                885                 890                 895     


Leu Thr Pro Asp Val Thr Gln Thr Phe Thr Gln Ala Gly Met Met Ser 
            900                 905                 910         


Lys Thr Gly Arg Cys Gln Thr Phe Asp Ala Glu Ala Asp Gly Tyr Val 
        915                 920                 925             


Arg Gly Glu Gly Cys Gly Val Val Leu Leu Lys Pro Leu Ala Gln Ala 
    930                 935                 940                 


Glu Arg Asp Gly Asp Asn Ile Leu Ala Val Ile His Gly Ser Ala Val 
945                 950                 955                 960 


Asn Gln Asp Gly Arg Ser Asn Gly Leu Thr Ala Pro Asn Gly Arg Ser 
                965                 970                 975     


Gln Gln Ala Val Ile Arg Gln Ala Leu Ala Gln Ala Gly Ile Thr Ala 
            980                 985                 990         


Ala Asp Leu Ala Tyr Leu Glu Ala  His Gly Thr Gly Thr  Pro Leu Gly 
        995                 1000                 1005             


Asp Pro  Ile Glu Ile Asn Ser  Leu Lys Ala Val Leu  Gln Thr Ala 
    1010                 1015                 1020             


Gln Arg  Glu Gln Pro Cys Val  Val Gly Ser Val Lys  Thr Asn Ile 
    1025                 1030                 1035             


Gly His  Leu Glu Ala Ala Ala  Gly Ile Ala Gly Leu  Ile Lys Val 
    1040                 1045                 1050             


Ile Leu  Ser Leu Glu His Gly  Met Ile Pro Gln His  Leu His Phe 
    1055                 1060                 1065             


Lys Gln  Leu Asn Pro Arg Ile  Asp Leu Asp Gly Leu  Val Thr Ile 
    1070                 1075                 1080             


Ala Ser  Lys Asp Gln Pro Trp  Ser Gly Gly Ser Gln  Lys Arg Phe 
    1085                 1090                 1095             


Ala Gly  Val Ser Ser Phe Gly  Phe Gly Gly Thr Asn  Ala His Val 
    1100                 1105                 1110             


Ile Val  Gly Asp Tyr Ala Gln  Gln Lys Ser Pro Leu  Ala Pro Pro 
    1115                 1120                 1125             


Ala Thr  Gln Asp Arg Pro Trp  His Leu Leu Thr Leu  Ser Ala Lys 
    1130                 1135                 1140             


Asn Ala  Gln Ala Leu Asn Ala  Leu Gln Lys Ser Tyr  Gly Asp Tyr 
    1145                 1150                 1155             


Leu Ala  Gln His Pro Ser Val  Asp Pro Arg Asp Leu  Cys Leu Ser 
    1160                 1165                 1170             


Ala Asn  Thr Gly Arg Ser Pro  Leu Lys Glu Arg Arg  Phe Phe Val 
    1175                 1180                 1185             


Phe Lys  Gln Val Ala Asp Leu  Gln Gln Thr Leu Asn  Gln Asp Phe 
    1190                 1195                 1200             


Leu Ala  Gln Pro Arg Leu Ser  Ser Pro Ala Lys Ile  Ala Phe Leu 
    1205                 1210                 1215             


Phe Thr  Gly Gln Gly Ser Gln  Tyr Tyr Gly Met Gly  Gln Gln Leu 
    1220                 1225                 1230             


Tyr Gln  Thr Ser Pro Val Phe  Arg Gln Val Leu Asp  Glu Cys Asp 
    1235                 1240                 1245             


Arg Leu  Trp Gln Thr Tyr Ser  Pro Glu Ala Pro Ala  Leu Thr Asp 
    1250                 1255                 1260             


Leu Leu  Tyr Gly Asn His Asn  Pro Asp Leu Val His  Glu Thr Val 
    1265                 1270                 1275             


Tyr Thr  Gln Pro Leu Leu Phe  Ala Val Glu Tyr Ala  Ile Ala Gln 
    1280                 1285                 1290             


Leu Trp  Leu Ser Trp Gly Val  Thr Pro Asp Phe Cys  Met Gly His 
    1295                 1300                 1305             


Ser Val  Gly Glu Tyr Val Ala  Ala Cys Leu Ala Gly  Val Phe Ser 
    1310                 1315                 1320             


Leu Ala  Asp Gly Met Lys Leu  Ile Thr Ala Arg Gly  Lys Leu Met 
    1325                 1330                 1335             


His Ala  Leu Pro Ser Asn Gly  Ser Met Ala Ala Val  Phe Ala Asp 
    1340                 1345                 1350             


Lys Thr  Val Ile Lys Pro Tyr  Leu Ser Glu His Leu  Thr Val Gly 
    1355                 1360                 1365             


Ala Glu  Asn Gly Ser His Leu  Val Leu Ser Gly Lys  Thr Pro Cys 
    1370                 1375                 1380             


Leu Glu  Ala Ser Ile His Lys  Leu Gln Ser Gln Gly  Ile Lys Thr 
    1385                 1390                 1395             


Lys Pro  Leu Lys Val Ser His  Ala Phe His Ser Pro  Leu Met Ala 
    1400                 1405                 1410             


Pro Met  Leu Ala Glu Phe Arg  Glu Ile Ala Glu Gln  Ile Thr Phe 
    1415                 1420                 1425             


His Pro  Pro Arg Ile Pro Leu  Ile Ser Asn Val Thr  Gly Gly Gln 
    1430                 1435                 1440             


Ile Glu  Ala Glu Ile Ala Gln  Ala Asp Tyr Trp Val  Lys His Val 
    1445                 1450                 1455             


Ser Gln  Pro Val Lys Phe Val  Gln Ser Ile Gln Thr  Leu Ala Gln 
    1460                 1465                 1470             


Ala Gly  Val Asn Val Tyr Leu  Glu Ile Gly Val Lys  Pro Val Leu 
    1475                 1480                 1485             


Leu Ser  Met Gly Arg His Cys  Leu Ala Glu Gln Glu  Ala Val Trp 
    1490                 1495                 1500             


Leu Pro  Ser Leu Arg Pro His  Ser Glu Pro Trp Pro  Glu Ile Leu 
    1505                 1510                 1515             


Thr Ser  Leu Gly Lys Leu Tyr  Glu Gln Gly Leu Asn  Ile Asp Trp 
    1520                 1525                 1530             


Gln Thr  Val Glu Ala Gly Asp  Arg Arg Arg Lys Leu  Ile Leu Pro 
    1535                 1540                 1545             


Thr Tyr  Pro Phe Gln Arg Gln  Arg Tyr Trp Phe Asn  Gln Gly Ser 
    1550                 1555                 1560             


Trp Gln  Thr Val Glu Thr Glu  Ser Val Asn Pro Gly  Pro Asp Asp 
    1565                 1570                 1575             


Leu Asn  Asp Trp Leu Tyr Gln  Val Ala Trp Thr Pro  Leu Asp Thr 
    1580                 1585                 1590             


Leu Pro  Pro Ala Pro Glu Pro  Ser Ala Lys Leu Trp  Leu Ile Leu 
    1595                 1600                 1605             


Gly Asp  Arg His Asp His Gln  Pro Ile Glu Ala Gln  Phe Lys Asn 
    1610                 1615                 1620             


Ala Gln  Arg Val Tyr Leu Gly  Gln Ser Asn His Phe  Pro Thr Asn 
    1625                 1630                 1635             


Ala Pro  Trp Glu Val Ser Ala  Asp Ala Leu Asp Asn  Leu Phe Thr 
    1640                 1645                 1650             


His Val  Gly Ser Gln Asn Leu  Ala Gly Ile Leu Tyr  Leu Cys Pro 
    1655                 1660                 1665             


Pro Gly  Glu Asp Pro Glu Asp  Leu Asp Glu Ile Gln  Lys Gln Thr 
    1670                 1675                 1680             


Ser Gly  Phe Ala Leu Gln Leu  Ile Gln Thr Leu Tyr  Gln Gln Lys 
    1685                 1690                 1695             


Ile Ala  Val Pro Cys Trp Phe  Val Thr His Gln Ser  Gln Arg Val 
    1700                 1705                 1710             


Leu Glu  Thr Asp Ala Val Thr  Gly Phe Ala Gln Gly  Gly Leu Trp 
    1715                 1720                 1725             


Gly Leu  Ala Gln Ala Ile Ala  Leu Glu His Pro Glu  Leu Trp Gly 
    1730                 1735                 1740             


Gly Ile  Ile Asp Val Asp Asp  Ser Leu Pro Asn Phe  Ala Gln Ile 
    1745                 1750                 1755             


Cys Gln  Gln Arg Gln Val Gln  Gln Leu Ala Val Arg  His Gln Lys 
    1760                 1765                 1770             


Leu Tyr  Gly Ala Gln Leu Lys  Lys Gln Pro Ser Leu  Pro Gln Lys 
    1775                 1780                 1785             


Asn Leu  Gln Ile Gln Pro Gln  Gln Thr Tyr Leu Val  Thr Gly Gly 
    1790                 1795                 1800             


Leu Gly  Ala Ile Gly Arg Lys  Ile Ala Gln Trp Leu  Ala Ala Ala 
    1805                 1810                 1815             


Gly Ala  Glu Lys Val Ile Leu  Val Ser Arg Arg Ala  Pro Ala Ala 
    1820                 1825                 1830             


Asp Gln  Gln Thr Leu Pro Thr  Asn Ala Val Val Tyr  Pro Cys Asp 
    1835                 1840                 1845             


Leu Ala  Asp Ala Ala Gln Val  Ala Lys Leu Phe Gln  Thr Tyr Pro 
    1850                 1855                 1860             


His Ile  Lys Gly Ile Phe His  Ala Ala Gly Thr Leu  Ala Asp Gly 
    1865                 1870                 1875             


Leu Leu  Gln Gln Gln Thr Trp  Gln Lys Phe Gln Thr  Val Ala Ala 
    1880                 1885                 1890             


Ala Lys  Met Lys Gly Thr Trp  His Leu His Arg His  Ser Gln Lys 
    1895                 1900                 1905             


Leu Asp  Leu Asp Phe Phe Val  Leu Phe Ser Ser Val  Ala Gly Val 
    1910                 1915                 1920             


Leu Gly  Ser Pro Gly Gln Gly  Asn Tyr Ala Ala Ala  Asn Arg Gly 
    1925                 1930                 1935             


Met Ala  Ala Ile Ala Gln Tyr  Arg Gln Ala Gln Gly  Leu Pro Ala 
    1940                 1945                 1950             


Leu Ala  Ile His Trp Gly Pro  Trp Ala Glu Gly Gly  Met Ala Asn 
    1955                 1960                 1965             


Ser Leu  Ser Asn Gln Asn Leu  Ala Trp Leu Pro Pro  Pro Gln Gly 
    1970                 1975                 1980             


Leu Thr  Ile Leu Glu Lys Val  Leu Gly Ala Gln Gly  Glu Met Gly 
    1985                 1990                 1995             


Val Phe  Lys Pro Asp Trp Gln  Asn Leu Ala Lys Gln  Phe Pro Glu 
    2000                 2005                 2010             


Phe Ala  Lys Thr His Tyr Phe  Ala Ala Val Ile Pro  Ser Ala Glu 
    2015                 2020                 2025             


Ala Val  Pro Pro Thr Ala Ser  Ile Phe Asp Lys Leu  Ile Asn Leu 
    2030                 2035                 2040             


Glu Ala  Ser Gln Arg Ala Asp  Tyr Leu Leu Asp Tyr  Leu Arg Arg 
    2045                 2050                 2055             


Ser Val  Ala Gln Ile Leu Lys  Leu Glu Ile Glu Gln  Ile Gln Ser 
    2060                 2065                 2070             


His Asp  Ser Leu Leu Asp Leu  Gly Met Asp Ser Leu  Met Ile Met 
    2075                 2080                 2085             


Glu Ala  Ile Ala Ser Leu Lys  Gln Asp Leu Gln Leu  Met Leu Tyr 
    2090                 2095                 2100             


Pro Arg  Glu Ile Tyr Glu Arg  Pro Arg Leu Asp Val  Leu Thr Ala 
    2105                 2110                 2115             


Tyr Leu  Ala Ala Glu Phe Thr  Lys Ala His Asp Ser  Glu Ala Ala 
    2120                 2125                 2130             


Thr Ala  Ala Ala Ala Ile Pro  Ser Gln Ser Leu Ser  Val Lys Thr 
    2135                 2140                 2145             


Lys Lys  Gln Trp Gln Lys Pro  Asp His Lys Asn Pro  Asn Pro Ile 
    2150                 2155                 2160             


Ala Phe  Ile Leu Ser Ser Pro  Arg Ser Gly Ser Thr  Leu Leu Arg 
    2165                 2170                 2175             


Val Met  Leu Ala Gly His Pro  Gly Leu Tyr Ser Pro  Pro Glu Leu 
    2180                 2185                 2190             


His Leu  Leu Pro Phe Glu Thr  Met Gly Asp Arg His  Gln Glu Leu 
    2195                 2200                 2205             


Gly Leu  Ser His Leu Gly Glu  Gly Leu Gln Arg Ala  Leu Met Asp 
    2210                 2215                 2220             


Leu Glu  Asn Leu Thr Pro Glu  Ala Ser Gln Ala Lys  Val Asn Gln 
    2225                 2230                 2235             


Trp Val  Lys Ala Asn Thr Pro  Ile Ala Asp Ile Tyr  Ala Tyr Leu 
    2240                 2245                 2250             


Gln Arg  Gln Ala Glu Gln Arg  Leu Leu Ile Asp Lys  Ser Pro Ser 
    2255                 2260                 2265             


Tyr Gly  Ser Asp Arg His Ile  Leu Asp His Ser Glu  Ile Leu Phe 
    2270                 2275                 2280             


Asp Gln  Ala Lys Tyr Ile His  Leu Val Arg His Pro  Tyr Ala Val 
    2285                 2290                 2295             


Ile Glu  Ser Phe Thr Arg Leu  Arg Met Asp Lys Leu  Leu Gly Ala 
    2300                 2305                 2310             


Glu Gln  Gln Asn Pro Tyr Ala  Leu Ala Glu Ser Ile  Trp Arg Thr 
    2315                 2320                 2325             


Ser Asn  Arg Asn Ile Leu Asp  Leu Gly Arg Thr Val  Gly Ala Asp 
    2330                 2335                 2340             


Arg Tyr  Leu Gln Val Ile Tyr  Glu Asp Leu Val Arg  Asp Pro Arg 
    2345                 2350                 2355             


Lys Val  Leu Thr Asn Ile Cys  Asp Phe Leu Gly Val  Asp Phe Asp 
    2360                 2365                 2370             


Glu Ala  Leu Leu Asn Pro Tyr  Ser Gly Asp Arg Leu  Thr Asp Gly 
    2375                 2380                 2385             


Leu His  Gln Gln Ser Met Gly  Val Gly Asp Pro Asn  Phe Leu Gln 
    2390                 2395                 2400             


His Lys  Thr Ile Asp Pro Ala  Leu Ala Asp Lys Trp  Arg Ser Ile 
    2405                 2410                 2415             


Thr Leu  Pro Ala Ala Leu Gln  Leu Asp Thr Ile Gln  Leu Ala Glu 
    2420                 2425                 2430             


Thr Phe  Ala Tyr Asp Leu Pro  Gln Glu Pro Gln Leu  Thr Pro Gln 
    2435                 2440                 2445             


Thr Gln  Ser Leu Pro Ser Met  Val Glu Arg Phe Val  Thr Val Arg 
    2450                 2455                 2460             


Gly Leu  Glu Thr Cys Leu Cys  Glu Trp Gly Asp Arg  His Gln Pro 
    2465                 2470                 2475             


Leu Val  Leu Leu Leu His Gly  Ile Leu Glu Gln Gly  Ala Ser Trp 
    2480                 2485                 2490             


Gln Leu  Ile Ala Pro Gln Leu  Ala Ala Gln Gly Tyr  Trp Val Val 
    2495                 2500                 2505             


Ala Pro  Asp Leu Arg Gly His  Gly Lys Ser Ala His  Ala Gln Ser 
    2510                 2515                 2520             


Tyr Ser  Met Leu Asp Phe Leu  Ala Asp Val Asp Ala  Leu Ala Lys 
    2525                 2530                 2535             


Gln Leu  Gly Asp Arg Pro Phe  Thr Leu Val Gly His  Ser Met Gly 
    2540                 2545                 2550             


Ser Ile  Ile Gly Ala Met Tyr  Ala Gly Ile Arg Gln  Thr Gln Val 
    2555                 2560                 2565             


Glu Lys  Leu Ile Leu Val Glu  Thr Ile Val Pro Asn  Asp Ile Asp 
    2570                 2575                 2580             


Asp Ala  Glu Thr Gly Asn His  Leu Thr Thr His Leu  Asp Tyr Leu 
    2585                 2590                 2595             


Ala Ala  Pro Pro Gln His Pro  Ile Phe Pro Ser Leu  Glu Val Ala 
    2600                 2605                 2610             


Ala Arg  Arg Leu Arg Gln Ala  Thr Pro Gln Leu Pro  Lys Asp Leu 
    2615                 2620                 2625             


Ser Ala  Phe Leu Thr Gln Arg  Ser Thr Lys Ser Val  Glu Lys Gly 
    2630                 2635                 2640             


Val Gln  Trp Arg Trp Asp Ala  Phe Leu Arg Thr Arg  Ala Gly Ile 
    2645                 2650                 2655             


Glu Phe  Asn Gly Ile Ser Arg  Arg Arg Tyr Leu Ala  Leu Leu Lys 
    2660                 2665                 2670             


Asp Ile  Gln Ala Pro Ile Thr  Leu Ile Tyr Gly Asp  Gln Ser Glu 
    2675                 2680                 2685             


Phe Asn  Arg Pro Ala Asp Leu  Gln Ala Ile Gln Ala  Ala Leu Pro 
    2690                 2695                 2700             


Gln Ala  Gln Arg Leu Thr Val  Ala Gly Gly His Asn  Leu His Phe 
    2705                 2710                 2715             


Glu Asn  Pro Gln Ala Ile Ala  Gln Ile Val Tyr Gln  Gln Leu Gln 
    2720                 2725                 2730             


Thr Pro  Val Pro Lys Thr Gln  Gly Leu His His His  His His His 
    2735                 2740                 2745             


Ser Ala  Trp Ser His Pro Gln  Phe Glu Lys 
    2750                 2755             


<210> 32
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
gggagctcaa ggaattatag ttatgcgcaa accctggtta ga                          42


<210> 33
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
ggcctgcagg ttatagggac tggatcgcca gttttttctg ct                          42


<210> 34
<211> 294
<212> DNA
<213> Streptomyces roseosporus

<400> 34
ctcgccgagg cctgcgagct gaccgccgcc actcccatgg gcggctggct gcccatgtac       60

cacgacatgg ggctcctggg cacgctgaca ccggccctgt acctcggcac cacgtgcgtg      120

ctgatgagct ccacggcatt catcaaacgg ccgcacctgt ggctacggac catcgaccgg      180

ttcggcctgg tctggtcgtc ggctcccgac ttcgcgtacg acatgtgtct gaagcgcgtc      240

accgacgagc agatcgccgg gctggacctg tcccgctggc ggtgggccgg caac            294


<210> 35
<211> 294
<212> DNA
<213> Legionella pneumophila

<400> 35
atttttacct cttttcatat gaatgatgaa accattattt tcagctggct gcccccacat       60

catgatatgg gtttgattgg ctgcattctg acccccatct atggtggaat tcaggcaatc      120

atgatgtccc ctttctcatt tttacaaaac ccgctttcct ggttaaaaca tattaccaaa      180

tacaaagcaa ctatcagtgg aagccctaac ttcgcttacg attattgtgt caaacgaatc      240

agggaagaaa aaaaagaagg gctggattta agttcatggg tgactgcttt caac            294


<210> 36
<211> 294
<212> DNA
<213> Bacillus subtilis

<400> 36
atccggaatg cgctggctat cgacttaaaa gatactcttt tatcttggat gcccttaacc       60

catgacatgg ggctcatagc ttgccacctt gttcctgcct tagccggaat caatcaaaat      120

ttaatgccga cagaattatt tattcgaaga cctattctct ggatgaaaaa agctcatgaa      180

cataaagcca gcattctatc ctcacctaat tttggataca attactttct taaatttctg      240

aaagacaata aaagttacga ctgggattta tcccatatca gggtcattgc aaac            294


<210> 37
<211> 951
<212> DNA
<213> Synechococcus sp.

<400> 37
gtgcgcaaac cctggttaga acttcccttg gcgatttttt cctttggctt ttataaagtc       60

aacaaatttc tgattgggaa tctctacact ttgtatttag cgctgaataa aaaaaatgct      120

aaggaatggc gcattattgg agaaaaatcc ctccagaaat tcctgagttt acccgtttta      180

atgaccaaag cgccccggtg gaatacccac gccattatcg gcaccctggg accactctct      240

gtagaaaaag aactcaccat taacctcgaa acgattcgtc aatccacgga agcttgggtc      300

ggttgcatct atgactttcc gggctatcgc acggtgttaa atttcacgca actcaccgat      360

gaccccaacc aaacagaact caaaattttc ttacctaaag ggaaatatac cgtcgggtta      420

cgttactacc atcccaaggt aaatcctcgc tttccggtcg ttaaaacaga tctaaatcta      480

accgtgccga ctttggttgt ttcgccccaa aacaacgact tttatcaagc cctggcccag      540

aaaacaaacc tttattttcg tctgcttcac tactacattt ttacgctatt taaatttcgc      600

gatgtcttac ccgctgcttt tgtgaaagga gaattcctcc ctgtcggcgc caccgatact      660

caattttttt acggcgcttt agaagcagca gaaaacttag agattaccat cccagccccc      720

tggcttcaga cctttgattt ttatctcacc ttctataacc gcgccagttt tcccctacgt      780

tggcaaaaaa tcaccgaagc gatgatctgt gatcccctgg gagaaaaagg ctattaccta      840

attcggatgc ggccccgtac tcaggacgcc gaggcacaat taccaacggt tagaggagaa      900

gaaacccagg tcacgcccca gcagaaaaaa ctggcgatcc agtccctata a               951


<210> 38
<211> 316
<212> PRT
<213> Synechococcus sp.

<400> 38
Met Arg Lys Pro Trp Leu Glu Leu Pro Leu Ala Ile Phe Ser Phe Gly 
1               5                   10                  15      


Phe Tyr Lys Val Asn Lys Phe Leu Ile Gly Asn Leu Tyr Thr Leu Tyr 
            20                  25                  30          


Leu Ala Leu Asn Lys Lys Asn Ala Lys Glu Trp Arg Ile Ile Gly Glu 
        35                  40                  45              


Lys Ser Leu Gln Lys Phe Leu Ser Leu Pro Val Leu Met Thr Lys Ala 
    50                  55                  60                  


Pro Arg Trp Asn Thr His Ala Ile Ile Gly Thr Leu Gly Pro Leu Ser 
65                  70                  75                  80  


Val Glu Lys Glu Leu Thr Ile Asn Leu Glu Thr Ile Arg Gln Ser Thr 
                85                  90                  95      


Glu Ala Trp Val Gly Cys Ile Tyr Asp Phe Pro Gly Tyr Arg Thr Val 
            100                 105                 110         


Leu Asn Phe Thr Gln Leu Thr Asp Asp Pro Asn Gln Thr Glu Leu Lys 
        115                 120                 125             


Ile Phe Leu Pro Lys Gly Lys Tyr Thr Val Gly Leu Arg Tyr Tyr His 
    130                 135                 140                 


Pro Lys Val Asn Pro Arg Phe Pro Val Val Lys Thr Asp Leu Asn Leu 
145                 150                 155                 160 


Thr Val Pro Thr Leu Val Val Ser Pro Gln Asn Asn Asp Phe Tyr Gln 
                165                 170                 175     


Ala Leu Ala Gln Lys Thr Asn Leu Tyr Phe Arg Leu Leu His Tyr Tyr 
            180                 185                 190         


Ile Phe Thr Leu Phe Lys Phe Arg Asp Val Leu Pro Ala Ala Phe Val 
        195                 200                 205             


Lys Gly Glu Phe Leu Pro Val Gly Ala Thr Asp Thr Gln Phe Phe Tyr 
    210                 215                 220                 


Gly Ala Leu Glu Ala Ala Glu Asn Leu Glu Ile Thr Ile Pro Ala Pro 
225                 230                 235                 240 


Trp Leu Gln Thr Phe Asp Phe Tyr Leu Thr Phe Tyr Asn Arg Ala Ser 
                245                 250                 255     


Phe Pro Leu Arg Trp Gln Lys Ile Thr Glu Ala Met Ile Cys Asp Pro 
            260                 265                 270         


Leu Gly Glu Lys Gly Tyr Tyr Leu Ile Arg Met Arg Pro Arg Thr Gln 
        275                 280                 285             


Asp Ala Glu Ala Gln Leu Pro Thr Val Arg Gly Glu Glu Thr Gln Val 
    290                 295                 300                 


Thr Pro Gln Gln Lys Lys Leu Ala Ile Gln Ser Leu 
305                 310                 315     


<210> 39
<211> 522
<212> PRT
<213> Bacillus subtilis

<400> 39
Ser Tyr Arg Gln Leu Phe Asp Glu Ala Gln Gly Phe Leu Gly Tyr Leu 
1               5                   10                  15      


Gln His Ile Gly Ile Gln Pro Lys Gln Glu Ile Val Phe Gln Ile Gln 
            20                  25                  30          


Glu Asn Lys Ser Phe Val Val Ala Phe Trp Ala Cys Leu Leu Gly Gly 
        35                  40                  45              


Met Ile Pro Val Pro Val Ser Ile Gly Glu Asp Asn Asp His Lys Leu 
    50                  55                  60                  


Lys Val Trp Arg Ile Trp Asn Ile Leu Asn Asn Pro Phe Leu Leu Ala 
65                  70                  75                  80  


Ser Glu Thr Val Leu Asp Lys Met Lys Lys Phe Ala Ala Asp His Asp 
                85                  90                  95      


Leu Gln Asp Phe His His Gln Leu Ile Glu Lys Ser Asp Ile Ile Gln 
            100                 105                 110         


Asp Arg Ile Tyr Asp His Pro Ala Ser Gln Tyr Glu Pro Glu Ala Asp 
        115                 120                 125             


Glu Leu Ala Phe Ile Gln Phe Ser Ser Gly Ser Thr Gly Asp Pro Lys 
    130                 135                 140                 


Gly Val Met Leu Thr His His Asn Leu Ile His Asn Thr Cys Ala Ile 
145                 150                 155                 160 


Arg Asn Ala Leu Ala Ile Asp Leu Lys Asp Thr Leu Leu Ser Trp Met 
                165                 170                 175     


Pro Leu Thr His Asp Met Gly Leu Ile Ala Cys His Leu Val Pro Ala 
            180                 185                 190         


Leu Ala Gly Ile Asn Gln Asn Leu Met Pro Thr Glu Leu Phe Ile Arg 
        195                 200                 205             


Arg Pro Ile Leu Trp Met Lys Lys Ala His Glu His Lys Ala Ser Ile 
    210                 215                 220                 


Leu Ser Ser Pro Asn Phe Gly Tyr Asn Tyr Phe Leu Lys Phe Leu Lys 
225                 230                 235                 240 


Asp Asn Lys Ser Tyr Asp Trp Asp Leu Ser His Ile Arg Val Ile Ala 
                245                 250                 255     


Asn Gly Ala Glu Pro Ile Leu Pro Glu Leu Cys Asp Glu Phe Leu Thr 
            260                 265                 270         


Arg Cys Ala Ala Phe Asn Met Lys Arg Ser Ala Ile Leu Asn Val Tyr 
        275                 280                 285             


Gly Leu Ala Glu Ala Ser Val Gly Ala Thr Phe Ser Asn Ile Gly Glu 
    290                 295                 300                 


Arg Phe Val Pro Val Tyr Leu His Arg Asp His Leu Asn Leu Gly Glu 
305                 310                 315                 320 


Arg Ala Val Glu Val Ser Lys Glu Asp Gln Asn Cys Ala Ser Phe Val 
                325                 330                 335     


Glu Val Gly Lys Pro Ile Asp Tyr Cys Gln Ile Arg Ile Cys Asn Glu 
            340                 345                 350         


Ala Asn Glu Gly Leu Glu Asp Gly Phe Ile Gly His Ile Gln Ile Lys 
        355                 360                 365             


Gly Glu Asn Val Thr Gln Gly Tyr Tyr Asn Asn Pro Glu Ser Thr Asn 
    370                 375                 380                 


Arg Ala Leu Thr Pro Asp Gly Trp Val Lys Thr Gly Asp Leu Gly Phe 
385                 390                 395                 400 


Ile Arg Lys Gly Asn Leu Val Val Thr Gly Arg Glu Lys Asp Ile Ile 
                405                 410                 415     


Phe Val Asn Gly Lys Asn Val Tyr Pro His Asp Ile Glu Arg Val Ala 
            420                 425                 430         


Ile Glu Leu Glu Asp Ile Asp Leu Gly Arg Val Ala Ala Cys Gly Val 
        435                 440                 445             


Tyr Asp Gln Glu Thr Arg Ser Arg Glu Ile Val Leu Phe Ala Val Tyr 
    450                 455                 460                 


Lys Lys Ser Ala Glu Gln Phe Ala Pro Leu Val Lys Asp Ile Lys Lys 
465                 470                 475                 480 


His Leu Tyr Gln Arg Gly Gly Trp Ser Ile Lys Glu Ile Leu Pro Ile 
                485                 490                 495     


Arg Lys Leu Pro Lys Thr Thr Ser Gly Lys Val Lys Arg Tyr Glu Leu 
            500                 505                 510         


Ala Glu Gln Tyr Glu Ser Gly Lys Phe Ala 
        515                 520         


<210> 40
<211> 548
<212> PRT
<213> Synechococcus sp.

<400> 40
Asp Leu Leu Gln Tyr Arg Ala Lys Leu Gln Ala Arg Lys Thr Val Phe 
1               5                   10                  15      


Ser Phe Leu Ala Asp Gly Glu Ala Glu Ser Ala Ala Leu Thr Tyr Gly 
            20                  25                  30          


Glu Leu Asp Gln Lys Ala Gln Ala Ile Ala Ala Phe Leu Gln Ala Asn 
        35                  40                  45              


Gln Ala Gln Gly Gln Arg Ala Leu Leu Leu Tyr Pro Pro Gly Leu Glu 
    50                  55                  60                  


Phe Ile Gly Ala Phe Leu Gly Cys Leu Tyr Ala Gly Val Val Ala Val 
65                  70                  75                  80  


Pro Ala Tyr Pro Pro Arg Pro Asn Lys Ser Phe Asp Arg Leu His Ser 
                85                  90                  95      


Ile Ile Gln Asp Ala Gln Ala Lys Phe Ala Leu Thr Thr Thr Glu Leu 
            100                 105                 110         


Lys Asp Lys Ile Ala Asp Arg Leu Glu Ala Leu Glu Gly Thr Asp Phe 
        115                 120                 125             


His Cys Leu Ala Thr Asp Gln Val Glu Leu Ile Ser Gly Lys Asn Trp 
    130                 135                 140                 


Gln Lys Pro Asn Ile Ser Gly Thr Asp Leu Ala Phe Leu Gln Tyr Thr 
145                 150                 155                 160 


Ser Gly Ser Thr Gly Asp Pro Lys Gly Val Met Val Ser His His Asn 
                165                 170                 175     


Leu Ile His Asn Ser Gly Leu Ile Asn Gln Gly Phe Gln Asp Thr Glu 
            180                 185                 190         


Ala Ser Met Gly Val Ser Trp Leu Pro Pro Tyr His Asp Met Gly Leu 
        195                 200                 205             


Ile Gly Gly Ile Leu Gln Pro Ile Tyr Val Gly Ala Thr Gln Ile Leu 
    210                 215                 220                 


Met Pro Pro Val Ala Phe Leu Gln Arg Pro Phe Arg Trp Leu Lys Ala 
225                 230                 235                 240 


Ile Asn Asp Tyr Arg Val Ser Thr Ser Gly Ala Pro Asn Phe Ala Tyr 
                245                 250                 255     


Asp Leu Cys Ala Ser Gln Ile Thr Pro Glu Gln Ile Arg Glu Leu Asp 
            260                 265                 270         


Leu Ser Cys Trp Arg Leu Ala Phe Ser Gly Ala Glu Pro Ile Arg Ala 
        275                 280                 285             


Val Thr Leu Glu Asn Phe Ala Lys Thr Phe Ala Thr Ala Gly Phe Gln 
    290                 295                 300                 


Lys Ser Ala Phe Tyr Pro Cys Tyr Gly Met Ala Glu Thr Thr Leu Ile 
305                 310                 315                 320 


Val Ser Gly Gly Asn Gly Arg Ala Gln Leu Pro Gln Glu Ile Ile Val 
                325                 330                 335     


Ser Lys Gln Gly Ile Glu Ala Asn Gln Val Arg Pro Ala Gln Gly Thr 
            340                 345                 350         


Glu Thr Thr Val Thr Leu Val Gly Ser Gly Glu Val Ile Gly Asp Gln 
        355                 360                 365             


Ile Val Lys Ile Val Asp Pro Gln Ala Leu Thr Glu Cys Thr Val Gly 
    370                 375                 380                 


Glu Ile Gly Glu Val Trp Val Lys Gly Glu Ser Val Ala Gln Gly Tyr 
385                 390                 395                 400 


Trp Gln Lys Pro Asp Leu Thr Gln Gln Gln Phe Gln Gly Asn Val Gly 
                405                 410                 415     


Ala Glu Thr Gly Phe Leu Arg Thr Gly Asp Leu Gly Phe Leu Gln Gly 
            420                 425                 430         


Gly Glu Leu Tyr Ile Thr Gly Arg Leu Lys Asp Leu Leu Ile Ile Arg 
        435                 440                 445             


Gly Arg Asn His Tyr Pro Gln Asp Ile Glu Leu Thr Val Glu Val Ala 
    450                 455                 460                 


His Pro Ala Leu Arg Gln Gly Ala Gly Ala Ala Val Ser Val Asp Val 
465                 470                 475                 480 


Asn Gly Glu Glu Gln Leu Val Ile Val Gln Glu Val Glu Arg Lys Tyr 
                485                 490                 495     


Ala Arg Lys Leu Asn Val Ala Ala Val Ala Gln Ala Ile Arg Gly Ala 
            500                 505                 510         


Ile Ala Ala Glu His Gln Leu Gln Pro Gln Ala Ile Cys Phe Ile Lys 
        515                 520                 525             


Pro Gly Ser Ile Pro Lys Thr Ser Ser Gly Lys Ile Arg Arg His Ala 
    530                 535                 540                 


Cys Lys Ala Gly 
545             


