                         SEQUENCE LISTING

<110>  Universit Joseph FOURIER (GRENOBLE 1)
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
 
<120>  Un nouveau leurre molculaire procoagulant pour le traitement des
        hmophilies A ou B avec ou sans inhibiteur

<130>  BR074169

<150>  FR11/51637
<151>  2011-03-01

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Asn Ser Phe Leu Glu Glu Met Lys Lys Gly His Leu Glu Arg Glu 
1               5                   10                  15      


Cys Met Glu Glu Thr Cys Ser Tyr Glu Glu Ala Arg Glu Val Phe Glu 
            20                  25                  30          


Asp Ser Asp Lys Thr Asn Glu Phe Trp Asn Lys Tyr Lys Asp Gly Asp 
        35                  40                  45              


Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys Cys Lys Asp Gly 
    50                  55                  60                  


Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe Glu Gly Lys Asn 
65                  70                  75                  80  


Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys 
                85                  90                  95      


Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala 
            100                 105                 110         


Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly 
        115                 120                 125             


Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg 
    130                 135                 140         


<210>  2
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
            20                  25                  30          


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40                  45              


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
    50                  55                  60                  


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
65                  70                  75                  80  


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
                85                  90                  95      


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
            100                 105                 110         


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
        115                 120                 125             


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys 
    130                 135                 140                 


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
145                 150                 155                 160 


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
                165                 170                 175     


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
            180                 185                 190         


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
        195                 200                 205             


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
    210                 215                 220                 


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
225                 230                 235                 240 


Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
                245                 250                 


<210>  3
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys 
1               5                   10                  15      


Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe 
            20                  25                  30          


Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu Asp 
        35                  40                  45              


Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val Val 
    50                  55                  60                  


Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala Cys 
65                  70                  75                  80  


Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg 
                85                  90                  95      


Lys Arg 
        


<210>  4
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  4

Phe Thr Arg Lys Leu Cys Ser Leu Asp Asn Gly Asp Cys Asp Gln Phe 
1               5                   10                  15      


Cys His Glu Glu Gln Asn Ser Val Val Cys Ser Cys Ala Arg Gly Tyr 
            20                  25                  30          


Thr Leu Ala Asp Asn Gly Lys Ala Cys Ile Pro Thr Gly Pro Tyr Pro 
        35                  40                  45              


Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys Arg 
    50                  55                  


<210>  5
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly Lys 
1               5                   10                  15      


Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly Phe 
            20                  25                  30          


Glu Gly Lys Asn Cys Glu Leu Phe Pro Thr Gly Pro Tyr Pro Cys Gly 
        35                  40                  45              


Lys Gln Thr Leu Glu Arg Arg Lys Arg 
    50                  55          


<210>  6
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  6

Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg Arg Lys 
1               5                   10                  15      


Arg 
    


<210>  7
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  7

Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly 
1               5                   10                  15      


Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly 
            20                  25                  30          


Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu 
        35                  40                  45              


Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val 
    50                  55                  60                  


Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala 
65                  70                  75                  80  


Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg 
                85                  90                  95      


Arg Lys Arg Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro 
            100                 105                 110         


Trp Gln Ala Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly 
        115                 120                 125             


Thr Ile Leu Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr 
    130                 135                 140                 


Gln Ala Lys Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln 
145                 150                 155                 160 


Glu Glu Gly Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His 
                165                 170                 175     


Asn Arg Phe Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg 
            180                 185                 190         


Leu Lys Thr Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu 
        195                 200                 205             


Pro Glu Arg Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly 
    210                 215                 220                 


Ile Val Ser Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr 
225                 230                 235                 240 


Arg Leu Lys Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys 
                245                 250                 255     


Leu Ser Ser Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr 
            260                 265                 270         


Asp Thr Lys Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His 
        275                 280                 285             


Val Thr Arg Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp 
    290                 295                 300                 


Gly Glu Gly Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
305                 310                 315                 320 


Thr Ala Phe Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu 
                325                 330                 335     


Pro Lys Ala Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu 
            340                 345                 350         


Lys 
    


<210>  8
<211>  1059
<212>  DNA
<213>  Homo sapiens

<400>  8
tacaaagatg gcgaccagtg tgagaccagt ccttgccaga accagggcaa atgtaaagac       60

ggcctcgggg aatacacctg cacctgttta gaaggattcg aaggcaaaaa ctgtgaatta      120

ttcacacgga agctctgcag cctggacaac ggggactgtg accagttctg ccacgaggaa      180

cagaactctg tggtgtgctc ctgcgcccgc gggtacaccc tggctgacaa cggcaaggcc      240

tgcattccca cagggcccta cccctgtggg aaacagaccc tggaacgcag gaagaggatc      300

gtgggaggcc aggaatgcaa ggacggggag tgtccctggc aggccctgct catcaatgag      360

gaaaacgagg gtttctgtgg tggaaccatt ctgagcgagt tctacatcct aacggcagcc      420

cactgtctct accaagccaa gagattcaag gtgagggtag gggaccggaa cacggagcag      480

gaggagggcg gtgaggcggt gcacgaggtg gaggtggtca tcaagcacaa ccggttcaca      540

aaggagacct atgacttcga catcgccgtg ctccggctca agacccccat caccttccgc      600

atgaacgtgg cgcctgcctg cctccccgag cgtgactggg ccgagtccac gctgatgacg      660

cagaagacgg ggattgtgag cggcttcggg cgcacccacg agaagggccg gcagtccacc      720

aggctcaaga tgctggaggt gccctacgtg gaccgcaaca gctgcaagct gtccagcagc      780

ttcatcatca cccagaacat gttctgtgcc ggctacgaca ccaagcagga ggatgcctgc      840

cagggggaca gcgggggccc gcacgtcacc cgcttcaagg acacctactt cgtgacaggc      900

atcgtcagct ggggagaggg ctgtgcccgt aaggggaagt acgggatcta caccaaggtc      960

accgccttcc tcaagtggat cgacaggtcc atgaaaacca ggggcttgcc caaggccaag     1020

agccatgccc cggaggtcat aacgtcctct ccattaaag                            1059


<210>  9
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  9

Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
            20                  25                  30          


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40                  45              


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
    50                  55                  60                  


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
65                  70                  75                  80  


Thr Tyr Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
                85                  90                  95      


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
            100                 105                 110         


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
        115                 120                 125             


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys 
    130                 135                 140                 


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
145                 150                 155                 160 


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
                165                 170                 175     


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
            180                 185                 190         


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
        195                 200                 205             


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
    210                 215                 220                 


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
225                 230                 235                 240 


Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
                245                 250                 


<210>  10
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  10

Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
            20                  25                  30          


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40                  45              


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
    50                  55                  60                  


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
65                  70                  75                  80  


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
                85                  90                  95      


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
            100                 105                 110         


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
        115                 120                 125             


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Phe Leu Lys 
    130                 135                 140                 


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
145                 150                 155                 160 


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
                165                 170                 175     


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
            180                 185                 190         


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
        195                 200                 205             


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
    210                 215                 220                 


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
225                 230                 235                 240 


Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
                245                 250                 


<210>  11
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  11

Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
            20                  25                  30          


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40                  45              


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
    50                  55                  60                  


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
65                  70                  75                  80  


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
                85                  90                  95      


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
            100                 105                 110         


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
        115                 120                 125             


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Gly Leu Lys 
    130                 135                 140                 


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
145                 150                 155                 160 


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
                165                 170                 175     


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
            180                 185                 190         


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
        195                 200                 205             


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
    210                 215                 220                 


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
225                 230                 235                 240 


Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
                245                 250                 


<210>  12
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  12

Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
            20                  25                  30          


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40                  45              


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
    50                  55                  60                  


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
65                  70                  75                  80  


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
                85                  90                  95      


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
            100                 105                 110         


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
        115                 120                 125             


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Ile Leu Lys 
    130                 135                 140                 


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
145                 150                 155                 160 


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
                165                 170                 175     


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
            180                 185                 190         


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
        195                 200                 205             


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
    210                 215                 220                 


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
225                 230                 235                 240 


Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
                245                 250                 


<210>  13
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  13

Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
            20                  25                  30          


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40                  45              


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
    50                  55                  60                  


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
65                  70                  75                  80  


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
                85                  90                  95      


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
            100                 105                 110         


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
        115                 120                 125             


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Gln Ser Thr Tyr Leu Lys 
    130                 135                 140                 


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
145                 150                 155                 160 


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
                165                 170                 175     


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
            180                 185                 190         


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
        195                 200                 205             


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
    210                 215                 220                 


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
225                 230                 235                 240 


Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
                245                 250                 


<210>  14
<211>  426
<212>  DNA
<213>  Homo sapiens

<400>  14
gccaattcct ttcttgaaga gatgaagaaa ggacacctcg aaagagagtg catggaagag       60

acctgctcat acgaagaggc ccgcgaggtc tttgaggaca gcgacaagac gaatgaattc      120

tggaataaat acaaagatgg cgaccagtgt gagaccagtc cttgccagaa ccagggcaaa      180

tgtaaagacg gcctcgggga atacacctgc acctgtttag aaggattcga aggcaaaaac      240

tgtgaattat tcacacggaa gctctgcagc ctggacaacg gggactgtga ccagttctgc      300

cacgaggaac agaactctgt ggtgtgctcc tgcgcccgcg ggtacaccct ggctgacaac      360

ggcaaggcct gcattcccac agggccctac ccctgtggga aacagaccct ggaacgcagg      420

aagagg                                                                 426


<210>  15
<211>  762
<212>  DNA
<213>  Homo sapiens

<400>  15
atcgtgggag gccaggaatg caaggacggg gagtgtccct ggcaggccct gctcatcaat       60

gaggaaaacg agggtttctg tggtggaacc attctgagcg agttctacat cctaacggca      120

gcccactgtc tctaccaagc caagagattc aaggtgaggg taggggaccg gaacacggag      180

caggaggagg gcggtgaggc ggtgcacgag gtggaggtgg tcatcaagca caaccggttc      240

acaaaggaga cctatgactt cgacatcgcc gtgctccggc tcaagacccc catcaccttc      300

cgcatgaacg tggcgcctgc ctgcctcccc gagcgtgact gggccgagtc cacgctgatg      360

acgcagaaga cggggattgt gagcggcttc gggcgcaccc acgagaaggg ccggcagtcc      420

accaggctca agatgctgga ggtgccctac gtggaccgca acagctgcaa gctgtccagc      480

agcttcatca tcacccagaa catgttctgt gccggctacg acaccaagca ggaggatgcc      540

tgccaggggg acagcggggg cccgcacgtc acccgcttca aggacaccta cttcgtgaca      600

ggcatcgtca gctggggaga gggctgtgcc cgtaagggga agtacgggat ctacaccaag      660

gtcaccgcct tcctcaagtg gatcgacagg tccatgaaaa ccaggggctt gcccaaggcc      720

aagagccatg ccccggaggt cataacgtcc tctccattaa ag                         762


<210>  16
<211>  297
<212>  DNA
<213>  Homo sapiens

<400>  16
tacaaagatg gcgaccagtg tgagaccagt ccttgccaga accagggcaa atgtaaagac       60

ggcctcgggg aatacacctg cacctgttta gaaggattcg aaggcaaaaa ctgtgaatta      120

ttcacacgga agctctgcag cctggacaac ggggactgtg accagttctg ccacgaggaa      180

cagaactctg tggtgtgctc ctgcgcccgc gggtacaccc tggctgacaa cggcaaggcc      240

tgcattccca cagggcccta cccctgtggg aaacagaccc tggaacgcag gaagagg         297


<210>  17
<211>  177
<212>  DNA
<213>  Homo sapiens

<400>  17
ttcacacgga agctctgcag cctggacaac ggggactgtg accagttctg ccacgaggaa       60

cagaactctg tggtgtgctc ctgcgcccgc gggtacaccc tggctgacaa cggcaaggcc      120

tgcattccca cagggcccta cccctgtggg aaacagaccc tggaacgcag gaagagg         177


<210>  18
<211>  171
<212>  DNA
<213>  Homo sapiens

<400>  18
aaagatggcg accagtgtga gaccagtcct tgccagaacc agggcaaatg taaagacggc       60

ctcggggaat acacctgcac ctgtttagaa ggattcgaag gcaaaaactg tgaattattc      120

cccacagggc cctacccctg tgggaaacag accctggaac gcaggaagag g               171


<210>  19
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  19
cccacagggc cctacccctg tgggaaacag accctggaac gcaggaagag g                51


<210>  20
<211>  1233
<212>  DNA
<213>  Homo sapiens

<400>  20
tacaaagatg gcgaccagtg tgagaccagt ccttgccaga accagggcaa atgtaaagac       60

ggcctcgggg aatacacctg cacctgttta gaaggattcg aaggcaaaaa ctgtgaatta      120

ttcacacgga agctctgcag cctggacaac ggggactgtg accagttctg ccacgaggaa      180

cagaactctg tggtgtgctc ctgcgcccgc gggtacaccc tggctgacaa cggcaaggcc      240

tgcattccca cagggcccta cccctgtggg aaacagaccc tggaacgcag gaagaggtca      300

gtggcccagg ccaccagcag cagcggggag gcccctgaca gcatcacatg gaagccatat      360

gatgcagccg acctggaccc caccgagaac cccttcgacc tgcttgactt caaccagacg      420

cagcctgaga ggggcgacaa caacctcacc aggaggaaga ggaggaagag gatcgtggga      480

ggccaggaat gcaaggacgg ggagtgtccc tggcaggccc tgctcatcaa tgaggaaaac      540

gagggtttct gtggtggaac cattctgagc gagttctaca tcctaacggc agcccactgt      600

ctctaccaag ccaagagatt caaggtgagg gtaggggacc ggaacacgga gcaggaggag      660

ggcggtgagg cggtgcacga ggtggaggtg gtcatcaagc acaaccggtt cacaaaggag      720

acctatgact tcgacatcgc cgtgctccgg ctcaagaccc ccatcacctt ccgcatgaac      780

gtggcgcctg cctgcctccc cgagcgtgac tgggccgagt ccacgctgat gacgcagaag      840

acggggattg tgagcggctt cgggcgcacc cacgagaagg gccggcagtc caccaggctc      900

aagatgctgg aggtgcccta cgtggaccgc aacagctgca agctgtccag cagcttcatc      960

atcacccaga acatgttctg tgccggctac gacaccaagc aggaggatgc ctgccagggg     1020

gacagcgggg gcccgcacgt cacccgcttc aaggacacct acttcgtgac aggcatcgtc     1080

agctggggag agggctgtgc ccgtaagggg aagtacggga tctacaccaa ggtcaccgcc     1140

ttcctcaagt ggatcgacag gtccatgaaa accaggggct tgcccaaggc caagagccat     1200

gccccggagg tcataacgtc ctctccatta aag                                  1233


<210>  21
<211>  762
<212>  DNA
<213>  Homo sapiens

<400>  21
atcgtgggag gccaggaatg caaggacggg gagtgtccct ggcaggccct gctcatcaat       60

gaggaaaacg agggtttctg tggtggaacc attctgagcg agttctacat cctaacggca      120

gcccactgtc tctaccaagc caagagattc aaggtgaggg taggggaccg gaacacggag      180

caggaggagg gcggtgaggc ggtgcacgag gtggaggtgg tcatcaagca caaccggttc      240

acatacgaga cctatgactt cgacatcgcc gtgctccggc tcaagacccc catcaccttc      300

cgcatgaacg tggcgcctgc ctgcctcccc gagcgtgact gggccgagtc cacgctgatg      360

acgcagaaga cggggattgt gagcggcttc gggcgcaccc acgagaaggg ccggcagtcc      420

accaggctca agatgctgga ggtgccctac gtggaccgca acagctgcaa gctgtccagc      480

agcttcatca tcacccagaa catgttctgt gccggctacg acaccaagca ggaggatgcc      540

tgccaggggg acagcggggg cccgcacgtc acccgcttca aggacaccta cttcgtgaca      600

ggcatcgtca gctggggaga gggctgtgcc cgtaagggga agtacgggat ctacaccaag      660

gtcaccgcct tcctcaagtg gatcgacagg tccatgaaaa ccaggggctt gcccaaggcc      720

aagagccatg ccccggaggt cataacgtcc tctccattaa ag                         762


<210>  22
<211>  762
<212>  DNA
<213>  Homo sapiens

<400>  22
atcgtgggag gccaggaatg caaggacggg gagtgtccct ggcaggccct gctcatcaat       60

gaggaaaacg agggtttctg tggtggaacc attctgagcg agttctacat cctaacggca      120

gcccactgtc tctaccaagc caagagattc aaggtgaggg taggggaccg gaacacggag      180

caggaggagg gcggtgaggc ggtgcacgag gtggaggtgg tcatcaagca caaccggttc      240

acaaaggaga cctatgactt cgacatcgcc gtgctccggc tcaagacccc catcaccttc      300

cgcatgaacg tggcgcctgc ctgcctcccc gagcgtgact gggccgagtc cacgctgatg      360

acgcagaaga cggggattgt gagcggcttc gggcgcaccc acgagaaggg ccggcagtcc      420

accttcctca agatgctgga ggtgccctac gtggaccgca acagctgcaa gctgtccagc      480

agcttcatca tcacccagaa catgttctgt gccggctacg acaccaagca ggaggatgcc      540

tgccaggggg acagcggggg cccgcacgtc acccgcttca aggacaccta cttcgtgaca      600

ggcatcgtca gctggggaga gggctgtgcc cgtaagggga agtacgggat ctacaccaag      660

gtcaccgcct tcctcaagtg gatcgacagg tccatgaaaa ccaggggctt gcccaaggcc      720

aagagccatg ccccggaggt cataacgtcc tctccattaa ag                         762


<210>  23
<211>  762
<212>  DNA
<213>  Homo sapiens

<400>  23
atcgtgggag gccaggaatg caaggacggg gagtgtccct ggcaggccct gctcatcaat       60

gaggaaaacg agggtttctg tggtggaacc attctgagcg agttctacat cctaacggca      120

gcccactgtc tctaccaagc caagagattc aaggtgaggg taggggaccg gaacacggag      180

caggaggagg gcggtgaggc ggtgcacgag gtggaggtgg tcatcaagca caaccggttc      240

acaaaggaga cctatgactt cgacatcgcc gtgctccggc tcaagacccc catcaccttc      300

cgcatgaacg tggcgcctgc ctgcctcccc gagcgtgact gggccgagtc cacgctgatg      360

acgcagaaga cggggattgt gagcggcttc gggcgcaccc acgagaaggg ccggcagtcc      420

accggactca agatgctgga ggtgccctac gtggaccgca acagctgcaa gctgtccagc      480

agcttcatca tcacccagaa catgttctgt gccggctacg acaccaagca ggaggatgcc      540

tgccaggggg acagcggggg cccgcacgtc acccgcttca aggacaccta cttcgtgaca      600

ggcatcgtca gctggggaga gggctgtgcc cgtaagggga agtacgggat ctacaccaag      660

gtcaccgcct tcctcaagtg gatcgacagg tccatgaaaa ccaggggctt gcccaaggcc      720

aagagccatg ccccggaggt cataacgtcc tctccattaa ag                         762


<210>  24
<211>  762
<212>  DNA
<213>  Homo sapiens

<400>  24
atcgtgggag gccaggaatg caaggacggg gagtgtccct ggcaggccct gctcatcaat       60

gaggaaaacg agggtttctg tggtggaacc attctgagcg agttctacat cctaacggca      120

gcccactgtc tctaccaagc caagagattc aaggtgaggg taggggaccg gaacacggag      180

caggaggagg gcggtgaggc ggtgcacgag gtggaggtgg tcatcaagca caaccggttc      240

acaaaggaga cctatgactt cgacatcgcc gtgctccggc tcaagacccc catcaccttc      300

cgcatgaacg tggcgcctgc ctgcctcccc gagcgtgact gggccgagtc cacgctgatg      360

acgcagaaga cggggattgt gagcggcttc gggcgcaccc acgagaaggg ccggcagtcc      420

accatactca agatgctgga ggtgccctac gtggaccgca acagctgcaa gctgtccagc      480

agcttcatca tcacccagaa catgttctgt gccggctacg acaccaagca ggaggatgcc      540

tgccaggggg acagcggggg cccgcacgtc acccgcttca aggacaccta cttcgtgaca      600

ggcatcgtca gctggggaga gggctgtgcc cgtaagggga agtacgggat ctacaccaag      660

gtcaccgcct tcctcaagtg gatcgacagg tccatgaaaa ccaggggctt gcccaaggcc      720

aagagccatg ccccggaggt cataacgtcc tctccattaa ag                         762


<210>  25
<211>  762
<212>  DNA
<213>  Homo sapiens

<400>  25
atcgtgggag gccaggaatg caaggacggg gagtgtccct ggcaggccct gctcatcaat       60

gaggaaaacg agggtttctg tggtggaacc attctgagcg agttctacat cctaacggca      120

gcccactgtc tctaccaagc caagagattc aaggtgaggg taggggaccg gaacacggag      180

caggaggagg gcggtgaggc ggtgcacgag gtggaggtgg tcatcaagca caaccggttc      240

acaaaggaga cctatgactt cgacatcgcc gtgctccggc tcaagacccc catcaccttc      300

cgcatgaacg tggcgcctgc ctgcctcccc gagcgtgact gggccgagtc cacgctgatg      360

acgcagaaga cggggattgt gagcggcttc gggcgcaccc acgagaaggg ccggcagtcc      420

acctacctca agatgctgga ggtgccctac gtggaccgca acagctgcaa gctgtccagc      480

agcttcatca tcacccagaa catgttctgt gccggctacg acaccaagca ggaggatgcc      540

tgccaggggg acagcggggg cccgcacgtc acccgcttca aggacaccta cttcgtgaca      600

ggcatcgtca gctggggaga gggctgtgcc cgtaagggga agtacgggat ctacaccaag      660

gtcaccgcct tcctcaagtg gatcgacagg tccatgaaaa ccaggggctt gcccaaggcc      720

aagagccatg ccccggaggt cataacgtcc tctccattaa ag                         762


<210>  26
<211>  254
<212>  PRT
<213>  Bovide

<400>  26

Ile Val Gly Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala 
1               5                   10                  15      


Leu Leu Ile Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu 
            20                  25                  30          


Ser Glu Phe Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys 
        35                  40                  45              


Arg Phe Lys Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly 
    50                  55                  60                  


Gly Glu Ala Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe 
65                  70                  75                  80  


Thr Lys Glu Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr 
                85                  90                  95      


Pro Ile Thr Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg 
            100                 105                 110         


Asp Trp Ala Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser 
        115                 120                 125             


Gly Phe Gly Arg Thr His Glu Lys Gly Arg Leu Ser Ser Thr Leu Lys 
    130                 135                 140                 


Met Leu Glu Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser 
145                 150                 155                 160 


Ser Phe Ile Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys 
                165                 170                 175     


Gln Glu Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg 
            180                 185                 190         


Phe Lys Asp Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly 
        195                 200                 205             


Cys Ala Arg Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe 
    210                 215                 220                 


Leu Lys Trp Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala 
225                 230                 235                 240 


Lys Ser His Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
                245                 250                 


<210>  27
<211>  765
<212>  DNA
<213>  Bovide

<400>  27
atcgtgggag gccaggaatg caaggacggg gagtgtccct ggcaggccct gctcatcaat       60

gaggaaaacg agggtttctg tggtggaacc attctgagcg agttctacat cctaacggca      120

gcccactgtc tctaccaagc caagagattc aaggtgaggg taggggaccg gaacacggag      180

caggaggagg gcggtgaggc ggtgcacgag gtggaggtgg tcatcaagca caaccggttc      240

acaaaggaga cctatgactt cgacatcgcc gtgctccggc tcaagacccc catcaccttc      300

cgcatgaacg tggcgcctgc ctgcctcccc gagcgtgact gggccgagtc cacgctgatg      360

acgcagaaga cggggattgt gagcggcttc gggcgcaccc acgagaaggg ccggctgtcc      420

tccacgctca agatgctgga ggtgccctac gtggaccgca acagctgcaa gctgtccagc      480

agcttcatca tcacccagaa catgttctgt gccggctacg acaccaagca ggaggatgcc      540

tgccaggggg acagcggggg cccgcacgtc acccgcttca aggacaccta cttcgtgaca      600

ggcatcgtca gctggggaga gggctgtgcc cgtaagggga agtacgggat ctacaccaag      660

gtcaccgcct tcctcaagtg gatcgacagg tccatgaaaa ccaggggctt gcccaaggcc      720

aagagccatg ccccggaggt cataacgtcc tctccattaa agtga                      765


<210>  28
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  28

Tyr Lys Asp Gly Asp Gln Cys Glu Thr Ser Pro Cys Gln Asn Gln Gly 
1               5                   10                  15      


Lys Cys Lys Asp Gly Leu Gly Glu Tyr Thr Cys Thr Cys Leu Glu Gly 
            20                  25                  30          


Phe Glu Gly Lys Asn Cys Glu Leu Phe Thr Arg Lys Leu Cys Ser Leu 
        35                  40                  45              


Asp Asn Gly Asp Cys Asp Gln Phe Cys His Glu Glu Gln Asn Ser Val 
    50                  55                  60                  


Val Cys Ser Cys Ala Arg Gly Tyr Thr Leu Ala Asp Asn Gly Lys Ala 
65                  70                  75                  80  


Cys Ile Pro Thr Gly Pro Tyr Pro Cys Gly Lys Gln Thr Leu Glu Arg 
                85                  90                  95      


Arg Lys Arg Ser Val Ala Gln Ala Thr Ser Ser Ser Gly Glu Ala Pro 
            100                 105                 110         


Asp Ser Ile Thr Trp Lys Pro Tyr Asp Ala Ala Asp Leu Asp Pro Thr 
        115                 120                 125             


Glu Asn Pro Phe Asp Leu Leu Asp Phe Asn Gln Thr Gln Pro Glu Arg 
    130                 135                 140                 


Gly Asp Asn Asn Leu Thr Arg Arg Lys Arg Arg Lys Arg Ile Val Gly 
145                 150                 155                 160 


Gly Gln Glu Cys Lys Asp Gly Glu Cys Pro Trp Gln Ala Leu Leu Ile 
                165                 170                 175     


Asn Glu Glu Asn Glu Gly Phe Cys Gly Gly Thr Ile Leu Ser Glu Phe 
            180                 185                 190         


Tyr Ile Leu Thr Ala Ala His Cys Leu Tyr Gln Ala Lys Arg Phe Lys 
        195                 200                 205             


Val Arg Val Gly Asp Arg Asn Thr Glu Gln Glu Glu Gly Gly Glu Ala 
    210                 215                 220                 


Val His Glu Val Glu Val Val Ile Lys His Asn Arg Phe Thr Lys Glu 
225                 230                 235                 240 


Thr Tyr Asp Phe Asp Ile Ala Val Leu Arg Leu Lys Thr Pro Ile Thr 
                245                 250                 255     


Phe Arg Met Asn Val Ala Pro Ala Cys Leu Pro Glu Arg Asp Trp Ala 
            260                 265                 270         


Glu Ser Thr Leu Met Thr Gln Lys Thr Gly Ile Val Ser Gly Phe Gly 
        275                 280                 285             


Arg Thr His Glu Lys Gly Arg Gln Ser Thr Arg Leu Lys Met Leu Glu 
    290                 295                 300                 


Val Pro Tyr Val Asp Arg Asn Ser Cys Lys Leu Ser Ser Ser Phe Ile 
305                 310                 315                 320 


Ile Thr Gln Asn Met Phe Cys Ala Gly Tyr Asp Thr Lys Gln Glu Asp 
                325                 330                 335     


Ala Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Arg Phe Lys Asp 
            340                 345                 350         


Thr Tyr Phe Val Thr Gly Ile Val Ser Trp Gly Glu Gly Cys Ala Arg 
        355                 360                 365             


Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Thr Ala Phe Leu Lys Trp 
    370                 375                 380                 


Ile Asp Arg Ser Met Lys Thr Arg Gly Leu Pro Lys Ala Lys Ser His 
385                 390                 395                 400 


Ala Pro Glu Val Ile Thr Ser Ser Pro Leu Lys 
                405                 410     


