                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
       Yeda Research and Development Co. Ltd.
       Offen, Daniel
       Dadon-Nachum, Michal
       Ben-Zur, Tali
       Melamed, Eldad
       Yaffe, David
 
<120>  GENETICALLY MODIFIED MUSCLE CELLS WHICH EXPRESS NEUROTROPHIC 
       FACTORS

<130>  53271

<150>  US 61/448,712
<151>  2011-03-03

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  485
<212>  DNA
<213>  Homo sapiens

<400>  1
caaatatgcc agaggattat cctgatcagt tcgatgatgt catggatttt attcaagcca       60

ccattaaaag actgaaaagg tcaccagata aacaaatggc agtgcttcct agaagagagc      120

ggaatcggca ggctgcagct gccaacccag agaattccag aggaaaaggt cggagaggcc      180

agaggggcaa aaaccggggt tgtgtcttaa ctgcaataca tttaaatgtc actgacttgg      240

gtctgggcta tgaaaccaag gaggaactga tttttaggta ctgcagcggc tcttgcgatg      300

cagctgagac aacgtacgac aaaatattga aaaacttatc cagaaataga aggctggtga      360

gtgacaaagt agggcaggca tgttgcagac ccatcgcctt tgatgatgac ctgtcgtttt      420

tagatgataa cctggtttac catattctaa gaaagcattc cgctaaaagg tgtggatgta      480

tctga                                                                  485


<210>  2
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  3
<211>  883
<212>  DNA
<213>  Homo sapiens

<400>  3
tgccatggtt acttttgcca cgatcttaca ggtgaacaag gtgatgtcca tcttgtttta       60

tgtgatattt ctcgcttatc tccgtggcat ccaaggtaac aacatggatc aaaggagttt      120

gccagaagac tcgctcaatt ccctcattat taagctgatc caggcagata ttttgaaaaa      180

caagctctcc aagcagatgg tggacgttaa ggaaaattac cagagcaccc tgcccaaagc      240

tgaggctccc cgagagccgg agcggggagg gcccgccaag tcagcattcc agccagtgat      300

tgcaatggac accgaactgc tgcgacaaca gagacgctac aactcaccgc gggtcctgct      360

gagcgacagc acccccttgg agcccccgcc cttgtatctc atggaggatt acgtgggcag      420

ccccgtggtg gcgaacagaa catcacggcg gaaacggtac gcggagcata agagtcaccg      480

aggggagtac tcggtatgtg acagtgagag tctgtgggtg accgacaagt catcggccat      540

cgacattcgg ggacaccagg tcacggtgct gggggagatc aaaacgggca actctcccgt      600

caaacaatat ttttatgaaa cgcgatgtaa ggaagccagg ccggtcaaaa acggttgcag      660

gggtattgat gataaacact ggaactctca gtgcaaaaca tcccaaacct acgtccgagc      720

actgacttca gagaacaata aactcgtggg ctggcggtgg atacggatag acacgtcctg      780

tgtgtgtgcc ttgtcgagaa aaatcggaag aacatgaatt ggcatctctc cccatatata      840

aattattact ttaaattata tgatatgcat gtagcatata aat                        883


<210>  4
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ile Leu Phe Tyr Val Ile Phe Leu Ala Tyr Leu Arg Gly Ile 
1               5                   10                  15      


Gln Gly Asn Asn Met Asp Gln Arg Ser Leu Pro Glu Asp Ser Leu Asn 
            20                  25                  30          


Ser Leu Ile Ile Lys Leu Ile Gln Ala Asp Ile Leu Lys Asn Lys Leu 
        35                  40                  45              


Ser Lys Gln Met Val Asp Val Lys Glu Asn Tyr Gln Ser Thr Leu Pro 
    50                  55                  60                  


Lys Ala Glu Ala Pro Arg Glu Pro Glu Arg Gly Gly Pro Ala Lys Ser 
65                  70                  75                  80  


Ala Phe Gln Pro Val Ile Ala Met Asp Thr Glu Leu Leu Arg Gln Gln 
                85                  90                  95      


Arg Arg Tyr Asn Ser Pro Arg Val Leu Leu Ser Asp Ser Thr Pro Leu 
            100                 105                 110         


Glu Pro Pro Pro Leu Tyr Leu Met Glu Asp Tyr Val Gly Ser Pro Val 
        115                 120                 125             


Val Ala Asn Arg Thr Ser Arg Arg Lys Arg Tyr Ala Glu His Lys Ser 
    130                 135                 140                 


His Arg Gly Glu Tyr Ser Val Cys Asp Ser Glu Ser Leu Trp Val Thr 
145                 150                 155                 160 


Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly His Gln Val Thr Val Leu 
                165                 170                 175     


Gly Glu Ile Lys Thr Gly Asn Ser Pro Val Lys Gln Tyr Phe Tyr Glu 
            180                 185                 190         


Thr Arg Cys Lys Glu Ala Arg Pro Val Lys Asn Gly Cys Arg Gly Ile 
        195                 200                 205             


Asp Asp Lys His Trp Asn Ser Gln Cys Lys Thr Ser Gln Thr Tyr Val 
    210                 215                 220                 


Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu Val Gly Trp Arg Trp Ile 
225                 230                 235                 240 


Arg Ile Asp Thr Ser Cys Val Cys Ala Leu Ser Arg Lys Ile Gly Arg 
                245                 250                 255     


Thr 
    


<210>  5
<211>  1335
<212>  DNA
<213>  Homo sapiens

<400>  5
ggggctgccg ccgccgcgcc cgggcgaccc gcccgctcgc tgtcccgcgc accccgtagc       60

gcctcgggct cccgggccgg acagaggagc ccggtgcgcc cctccacctc ctgctcgggg      120

ggctttaatg agacacccac cgctgctgtg gggccggcgg ggagcagcac cgcgacgggg      180

accggggctg ggcgctggag ccagaatcgg aaccacgatt tgactccgcc gccggggacc      240

cgtgagtttg tgtggacccc gagttccacc aggtgagaag agtgatgacc atccttttcc      300

ttactatggt tatttcatac tttggttgca tgaaggctgc ccccatgaaa gaagcaaaca      360

tccgaggaca aggtggcttg gcctacccag gtgtgcggac ccatgggact ctggagagcg      420

tgaatgggcc caaggcaggt tcaagaggct tgacatcatt ggctgacact ttcgaacacg      480

tgatagaaga gctgttggat gaggaccata aagttcggcc caatgaagaa aacaataagg      540

acgcagactt gtacacgtcc agggtgatgc tcagtagtca agtgcctttg gagcctcctc      600

ttctctttct gctggaggaa tacaaaaatt acctagatgc tgcaaacatg tccatgatgg      660

tcctgcgcca ctctgaccct gcccgccgag gggagctgag cgtgtgtgac agtattagtg      720

agtgggtaac ggcggcagac aaaaagactg cagtggacat gtcgggcggg acggtcacag      780

tccttgaaaa ggtccctgta tcaaaaggcc aactgaagca atacttctac gagaccaagt      840

gcaatcccat gggttacaca aaagaaggct gcaggggcat agacaaaagg cattggaact      900

cccagtgccg aactacccag tcgtacgtgc gggcccttac catggatagc aaaaagagaa      960

ttggctggcg attcataagg atagacactt cttgtgtatg tacattgacc attaaaaggg     1020

gaagatagtg gatttatgtt gtatagatta gattatattg agacaaaaat tatctatttg     1080

tatatataca taacagggta aattattcag ttaagaaaaa aataatttta ttaactgcat     1140

gtataaatga agtttataca gtacagtggt tctacaatct atttattgga catgtccatg     1200

accagaaggg aaacagtcat ttgcgcacaa cttaaaaagt ctgcattaca ttccttgata     1260

atgttgtggt ttgttgccgt tgccaagaac tgaaaacata aaaatttaaa aaaaataatc     1320

ccttgcatgc tgccc                                                      1335


<210>  6
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp His Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Met Val Leu Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  7
<211>  1020
<212>  DNA
<213>  Homo sapiens

<400>  7
taacacagac tcagctgcca gagcctgctc ttaacacctg tgtttccttt tcagatctta       60

caggtgaaca aggtgatgtc catcttgttt tatgtgatat ttctcgctta tctccgtggc      120

atccaaggta acaacatgga tcaaaggagt ttgccagaag actcgctcaa ttccctcatt      180

attaagctga tccaggcaga tattttgaaa aacaagctct ccaagcagat ggtggacgtt      240

aaggaaaatt accagagcac cctgcccaaa gctgaggctc cccgagagcc ggagcgggga      300

gggcccgcca agtcagcatt ccagccggtg attgcaatgg acaccgaact gctgcgacaa      360

cagagacgct acaactcacc gcgggtcctg ctgagcgaca gcaccccctt ggagcccccg      420

cccttgtatc tcatggagga ttacgtgggc agccccgtgg tggcgaacag aacatcacgg      480

cggaaacggt acgcggagca taagagtcac cgaggggagt actcggtatg tgacagtgag      540

agtctgtggg tgaccgacaa gtcatcggcc atcgacattc ggggacacca ggtcacggtg      600

ctgggggaga tcaaaacggg caactctccc gtcaaacaat atttttatga aacgcgatgt      660

aaggaagcca ggccggtcaa aaacggttgc aggggtattg atgataaaca ctggaactct      720

cagtgcaaaa catcccaaac ctacgtccga gcactgactt cagagaacaa taaactcgtg      780

ggctggcggt ggatacggat agacacgtcc tgtgtgtgtg ccttgtcgag aaaaatcgga      840

agaacatgaa ttggcatctc tccccatata taaattatta ctttaaatta tatgatatgc      900

atgtagcata taaatgttta tattgttttt atatattata agttgacctt tatttattaa      960

acttcagcaa ccctacagta tataagcttt tttctcaata aaatcagtgt gcttgccttc     1020


<210>  8
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Ile Leu Phe Tyr Val Ile Phe Leu Ala Tyr Leu Arg Gly Ile 
1               5                   10                  15      


Gln Gly Asn Asn Met Asp Gln Arg Ser Leu Pro Glu Asp Ser Leu Asn 
            20                  25                  30          


Ser Leu Ile Ile Lys Leu Ile Gln Ala Asp Ile Leu Lys Asn Lys Leu 
        35                  40                  45              


Ser Lys Gln Met Val Asp Val Lys Glu Asn Tyr Gln Ser Thr Leu Pro 
    50                  55                  60                  


Lys Ala Glu Ala Pro Arg Glu Pro Glu Arg Gly Gly Pro Ala Lys Ser 
65                  70                  75                  80  


Ala Phe Gln Pro Val Ile Ala Met Asp Thr Glu Leu Leu Arg Gln Gln 
                85                  90                  95      


Arg Arg Tyr Asn Ser Pro Arg Val Leu Leu Ser Asp Ser Thr Pro Leu 
            100                 105                 110         


Glu Pro Pro Pro Leu Tyr Leu Met Glu Asp Tyr Val Gly Ser Pro Val 
        115                 120                 125             


Val Ala Asn Arg Thr Ser Arg Arg Lys Arg Tyr Ala Glu His Lys Ser 
    130                 135                 140                 


His Arg Gly Glu Tyr Ser Val Cys Asp Ser Glu Ser Leu Trp Val Thr 
145                 150                 155                 160 


Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly His Gln Val Thr Val Leu 
                165                 170                 175     


Gly Glu Ile Lys Thr Gly Asn Ser Pro Val Lys Gln Tyr Phe Tyr Glu 
            180                 185                 190         


Thr Arg Cys Lys Glu Ala Arg Pro Val Lys Asn Gly Cys Arg Gly Ile 
        195                 200                 205             


Asp Asp Lys His Trp Asn Ser Gln Cys Lys Thr Ser Gln Thr Tyr Val 
    210                 215                 220                 


Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu Val Gly Trp Arg Trp Ile 
225                 230                 235                 240 


Arg Ile Asp Thr Ser Cys Val Cys Ala Leu Ser Arg Lys Ile Gly Arg 
                245                 250                 255     


Thr 
    


<210>  9
<211>  1141
<212>  DNA
<213>  Homo sapiens

<400>  9
ccacactcag tctggcctcg gggcctttgc actggctgtg tcccctgcct gtgatgccat       60

tctcctctgc ctggccaact cctacgttta ttcaagtctg gaccttgtca tcggctcctc      120

aggaaggcac tccgggaccc ccagatgggg gcggttccct gtgactcctg gcacggaggc      180

caaccccttc cttgttcaat ggttccttga gggaccattc ccatgtgatt atcgaccatt      240

cggcaggcgt tcaaagtcaa aggccccaca ctgagtcctg gcccagcgcc ctgtgcccgt      300

tggctgctgg agggacagac ggggcgtgcg gctgaccatc ccgtgcccgc aggctgagga      360

tgcagcgctg gaaggcggcg gccttggcct cagtgctctg cagctccgtg ctgtccatct      420

ggatgtgtcg agagggcctg cttctcagcc accgcctcgg acctgcgctg gtccccctgc      480

accgcctgcc tcgaaccctg gacgcccgga ttgcccgcct ggcccagtac cgtgcactcc      540

tgcagggggc cccggatgcg atggagctgc gcgagctgac gccctgggct gggcggcccc      600

caggtccgcg ccgtcgggcg gggccccggc ggcggcgcgc gcgtgcgcgg ttgggggcgc      660

ggccttgcgg gctgcgcgag ctggaggtgc gcgtgagcga gctgggcctg ggctacgcgt      720

ccgacgagac ggtgctgttc cgctactgcg caggcgcctg cgaggctgcc gcgcgcgtct      780

acgacctcgg gctgcgacga ctgcgccagc ggcggcgcct gcggcgggag cgggtgcgcg      840

cgcagccctg ctgccgcccg acggcctacg aggacgaggt gtccttcctg gacgcgcaca      900

gccgctacca cacggtgcac gagctgtcgg cgcgcgagtg cgcctgcgtg tgaccctacc      960

tcactcggcc ggcgcggcgg ccactccccc cgcctcgacg gcaccactgg ccggccccgc     1020

gaaagactgc gcgtgcgtag agcacgccgg cgcggccccg ggactctcgc gataactgta     1080

ctgagataaa gtgtggcaac tcgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1140

a                                                                     1141


<210>  10
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gln Arg Trp Lys Ala Ala Ala Leu Ala Ser Val Leu Cys Ser Ser 
1               5                   10                  15      


Val Leu Ser Ile Trp Met Cys Arg Glu Gly Leu Leu Leu Ser His Arg 
            20                  25                  30          


Leu Gly Pro Ala Leu Val Pro Leu His Arg Leu Pro Arg Thr Leu Asp 
        35                  40                  45              


Ala Arg Ile Ala Arg Leu Ala Gln Tyr Arg Ala Leu Leu Gln Gly Ala 
    50                  55                  60                  


Pro Asp Ala Met Glu Leu Arg Glu Leu Thr Pro Trp Ala Gly Arg Pro 
65                  70                  75                  80  


Pro Gly Pro Arg Arg Arg Ala Gly Pro Arg Arg Arg Arg Ala Arg Ala 
                85                  90                  95      


Arg Leu Gly Ala Arg Pro Cys Gly Leu Arg Glu Leu Glu Val Arg Val 
            100                 105                 110         


Ser Glu Leu Gly Leu Gly Tyr Ala Ser Asp Glu Thr Val Leu Phe Arg 
        115                 120                 125             


Tyr Cys Ala Gly Ala Cys Glu Ala Ala Ala Arg Val Tyr Asp Leu Gly 
    130                 135                 140                 


Leu Arg Arg Leu Arg Gln Arg Arg Arg Leu Arg Arg Glu Arg Val Arg 
145                 150                 155                 160 


Ala Gln Pro Cys Cys Arg Pro Thr Ala Tyr Glu Asp Glu Val Ser Phe 
                165                 170                 175     


Leu Asp Ala His Ser Arg Tyr His Thr Val His Glu Leu Ser Ala Arg 
            180                 185                 190         


Glu Cys Ala Cys Val 
        195         


<210>  11
<211>  1404
<212>  DNA
<213>  Homo sapiens

<400>  11
cttgtcaccc aggtggcagg ggagtggtgc actctctgct cactgcaacc tcggcctcct       60

gggttcgagt gattctccta cctcagccta ctgagtagct gggattacag gcgtgcagca      120

ctatgcccgg ttaattttgg tatttttggt agagatgagg tttcaccatg ttgaccagct      180

gctctggaac tcctgacctc aagtcatcca cctgcctcag cctcccagag tgctgggatt      240

agaggtgtgg ggcacagtgc ctggcctgta gtagttgaat atttattatt aatctacaag      300

ttgcgcatta cgcaagccct agatataggg tcccccaaac ttctagaaca agggcttccc      360

cacaatcctg gcaggcaagc ctcccctggg gttcccaact tctttcccca ctgaagtttt      420

tacccccttc tctaatccca gcctccctct ttctgtctcc aggtgctccg agagatgctc      480

cctctcccct catgctccct ccccatcctc ctccttttcc tcctccccag tgtgccaatt      540

gagtcccaac ccccaccctc aacattgccc ccttttctgg cccctgagtg ggaccttctc      600

tccccccgag tagtcctgtc taggggtgcc cctgctgggc cccctctgct cttcctgctg      660

gaggctgggg cctttcggga gtcagcaggt gccccggcca accgcagccg gcgtggggtg      720

agcgaaactg caccagcgag tcgtcggggt gagctggctg tgtgcgatgc agtcagtggc      780

tgggtgacag accgccggac cgctgtggac ttgcgtgggc gcgaggtgga ggtgttgggc      840

gaggtgcctg cagctggcgg cagtcccctc cgccagtact tctttgaaac ccgctgcaag      900

gctgataacg ctgaggaagg tggcccgggg gcaggtggag ggggctgccg gggagtggac      960

aggaggcact gggtatctga gtgcaaggcc aagcagtcct atgtgcgggc attgaccgct     1020

gatgcccagg gccgtgtggg ctggcgatgg attcgaattg acactgcctg cgtctgcaca     1080

ctcctcagcc ggactggccg ggcctgagac ccatgcccag gaaaataaca gagctggatg     1140

ctgagagacc tcagggatgg cccagctgat ctaaggaccc cagtttggga actcatcaaa     1200

taatcacaaa atcacaattc tctgattttg agctcaatct ctgcaggatg ggtgaaacca     1260

catggggttt tggaggttga ataggagttc tcctggagca acttgagggt aataatgatg     1320

atgatataat aataatagcc actatttact gagtgtttac tgtttcttat ccctaataca     1380

taactcctca gatcaactct catg                                            1404


<210>  12
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Leu Pro Leu Pro Ser Cys Ser Leu Pro Ile Leu Leu Leu Phe Leu 
1               5                   10                  15      


Leu Pro Ser Val Pro Ile Glu Ser Gln Pro Pro Pro Ser Thr Leu Pro 
            20                  25                  30          


Pro Phe Leu Ala Pro Glu Trp Asp Leu Leu Ser Pro Arg Val Val Leu 
        35                  40                  45              


Ser Arg Gly Ala Pro Ala Gly Pro Pro Leu Leu Phe Leu Leu Glu Ala 
    50                  55                  60                  


Gly Ala Phe Arg Glu Ser Ala Gly Ala Pro Ala Asn Arg Ser Arg Arg 
65                  70                  75                  80  


Gly Val Ser Glu Thr Ala Pro Ala Ser Arg Arg Gly Glu Leu Ala Val 
                85                  90                  95      


Cys Asp Ala Val Ser Gly Trp Val Thr Asp Arg Arg Thr Ala Val Asp 
            100                 105                 110         


Leu Arg Gly Arg Glu Val Glu Val Leu Gly Glu Val Pro Ala Ala Gly 
        115                 120                 125             


Gly Ser Pro Leu Arg Gln Tyr Phe Phe Glu Thr Arg Cys Lys Ala Asp 
    130                 135                 140                 


Asn Ala Glu Glu Gly Gly Pro Gly Ala Gly Gly Gly Gly Cys Arg Gly 
145                 150                 155                 160 


Val Asp Arg Arg His Trp Val Ser Glu Cys Lys Ala Lys Gln Ser Tyr 
                165                 170                 175     


Val Arg Ala Leu Thr Ala Asp Ala Gln Gly Arg Val Gly Trp Arg Trp 
            180                 185                 190         


Ile Arg Ile Asp Thr Ala Cys Val Cys Thr Leu Leu Ser Arg Thr Gly 
        195                 200                 205             


Arg Ala 
    210 


<210>  13
<211>  471
<212>  DNA
<213>  Homo sapiens

<400>  13
atggccgtag ggaagttcct gctgggctct ctgctgctcc tgtccctgca gctgggacag       60

ggctggggcc ccgatgcccg tggggttccc gtggccgatg gagagttctc gtctgaacag      120

gtggcaaagg ctggagggac ctggctgggc acccaccgcc cccttgcccg cctgcgccga      180

gccctgtctg gtccatgcca gctgtggagc ctgaccctgt ccgtggcaga gctaggcctg      240

ggctacgcct cagaggagaa ggtcatcttc cgctactgcg ccggcagctg cccccgtggt      300

gcccgcaccc agcatggcct ggcgctggcc cggctgcagg gccagggccg agcccacggt      360

gggccctgct gccggcccac tcgctacacc gacgtggcct tcctcgatga ccgccaccgc      420

tggcagcggc tgccccagct ctcggcggct gcctgcggct gtggtggctg a               471


<210>  14
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Val Gly Lys Phe Leu Leu Gly Ser Leu Leu Leu Leu Ser Leu 
1               5                   10                  15      


Gln Leu Gly Gln Gly Trp Gly Pro Asp Ala Arg Gly Val Pro Val Ala 
            20                  25                  30          


Asp Gly Glu Phe Ser Ser Glu Gln Val Ala Lys Ala Gly Gly Thr Trp 
        35                  40                  45              


Leu Gly Thr His Arg Pro Leu Ala Arg Leu Arg Arg Ala Leu Ser Gly 
    50                  55                  60                  


Pro Cys Gln Leu Trp Ser Leu Thr Leu Ser Val Ala Glu Leu Gly Leu 
65                  70                  75                  80  


Gly Tyr Ala Ser Glu Glu Lys Val Ile Phe Arg Tyr Cys Ala Gly Ser 
                85                  90                  95      


Cys Pro Arg Gly Ala Arg Thr Gln His Gly Leu Ala Leu Ala Arg Leu 
            100                 105                 110         


Gln Gly Gln Gly Arg Ala His Gly Gly Pro Cys Cys Arg Pro Thr Arg 
        115                 120                 125             


Tyr Thr Asp Val Ala Phe Leu Asp Asp Arg His Arg Trp Gln Arg Leu 
    130                 135                 140                 


Pro Gln Leu Ser Ala Ala Ala Cys Gly Cys Gly Gly 
145                 150                 155     


<210>  15
<211>  1652
<212>  DNA
<213>  Homo sapiens

<400>  15
ctctgagctt ctctgagcct tgtttgctca tctggaaaaa ggggattaaa ccatttacct       60

catggagttg tgaaagaata gctgcaaagc acctaacaca tagtaaggtt cccagtgcag      120

ctacttctgc tgggttgagt ctagctgtgt aggccccttg ttcctcacct ggagaaactg      180

gggtggcagg ccggtccccc acaaaagata actcatctct taatttgcaa gctgcctcaa      240

caggagggtg ggggaacagc tcaacaatgg ctgatgggcg ctcctggtgt tgatagagat      300

ggaacttgga cttggaggcc tctccacgct gtcccactgc ccctggccta ggcggcaggt      360

gagtggttct cccagtgact cctacctggt actgaggaaa ggcggcttga ctggtgaggg      420

agagcagggc ttggcttggg cagcggttag gtgtgggagg gaaaatggtc agggagggac      480

caggtgaatg ggaggaggag cgggacttct ctgaatggtc ggtgcactca ggtgattcct      540

cccctgggct cccagaggca gcaaacccat tatactggaa cctaggccct tcctgagttt      600

cccctccaca cagctaggag cccatgcccg gcctgatctc agcccgagga cagcccctcc      660

ttgaggtcct tcctccccaa gcccacctgg gtgccctctt tctccctgag gctccacttg      720

gtctctccgc gcagcctgcc ctgtggccca ccctggccgc tctggctctg ctgagcagcg      780

tcgcagaggc ctccctgggc tccgcgcccc gcagccctgc cccccgcgaa ggccccccgc      840

ctgtcctggc gtcccccgcc ggccacctgc cgggtaggtg agagggcgag ggggcggggc      900

ggggctggcc cgggacaccg cgcgtgactg ggtctcattc cagggggacg cacggcccgc      960

tggtgcagtg gaagagcccg gcggccgccg ccgcagcctt ctcggcccgc gcccccgccg     1020

cctgcacccc catctgctct tccccgcggg ggccgcgcgg cgcgggctgg gggcccgggc     1080

agccgcgctc gggcagcggg ggcgcggggc tgccgcctgc gctcgcagct ggtgccggtg     1140

cgcgcgctcg gcctgggcca ccgctccgac gagctggtgc gtttccgctt ctgcagcggc     1200

tcctgccgcc gcgcgcgctc tccacacgac ctcagcctgg ccagcctact gggcgccggg     1260

gccctgcgac cgcccccggg ctcccggccc gtcagccagc cctgctgccg acccacgcgc     1320

tacgaagcgg tctccttcat ggacgtcaac agcacctgga gaaccgtgga ccgcctctcc     1380

gccaccgcct gcggctgcct gggctgaggg ctcgctccag ggctttgcag actggaccct     1440

taccggtggc tcttcctgcc tgggaccctc ccgcagagtc ccactagcca gcggcctcag     1500

ccagggacga aggcctcaaa gctgagaggc ccctgccggt gggtgatgga tatcatcccc     1560

gaacaggtga agggacaact gactagcagc cccagagccc tcaccctgcg gatcccagcc     1620

taaaagacac cagagacctc agctatggag cc                                   1652


<210>  16
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Pro Gly Leu Ile Ser Ala Arg Gly Gln Pro Leu Leu Glu Val Leu 
1               5                   10                  15      


Pro Pro Gln Ala His Leu Gly Ala Leu Phe Leu Pro Glu Ala Pro Leu 
            20                  25                  30          


Gly Leu Ser Ala Gln Pro Ala Leu Trp Pro Thr Leu Ala Ala Leu Ala 
        35                  40                  45              


Leu Leu Ser Ser Val Ala Glu Ala Ser Leu Gly Ser Ala Pro Arg Ser 
    50                  55                  60                  


Pro Ala Pro Arg Glu Gly Pro Pro Pro Val Leu Ala Ser Pro Ala Gly 
65                  70                  75                  80  


His Leu Pro Gly Gly Arg Thr Ala Arg Trp Cys Ser Gly Arg Ala Arg 
                85                  90                  95      


Arg Pro Pro Pro Gln Pro Ser Arg Pro Ala Pro Pro Pro Pro Ala Pro 
            100                 105                 110         


Pro Ser Ala Leu Pro Arg Gly Gly Arg Ala Ala Arg Ala Gly Gly Pro 
        115                 120                 125             


Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser 
    130                 135                 140                 


Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu 
145                 150                 155                 160 


Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser 
                165                 170                 175     


Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg 
            180                 185                 190         


Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr 
        195                 200                 205             


Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr 
    210                 215                 220                 


Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
225                 230                 235         


<210>  17
<211>  1914
<212>  DNA
<213>  Homo sapiens

<400>  17
agagtcacat ctcttatttg gaccagtata gacagaagta aacccagctg acttgtttcc       60

tgggacagtt gagttaaggg atggctttca cagagcattc accgctgacc cctcaccgtc      120

gggacctctg tagccgctct atctggctag caaggaagat tcgttcagac ctgactgctc      180

ttacggaatc ctatgtgaag catcagggcc tgaacaagaa catcaacctg gactctgcgg      240

atgggatgcc agtggcaagc actgatcagt ggagtgagct gaccgaggca gagcgactcc      300

aagagaacct tcaagcttat cgtaccttcc atgttttgtt ggccaggctc ttagaagacc      360

agcaggtgca ttttacccca accgaaggtg acttccatca agctatacat acccttcttc      420

tccaagtcgc tgcctttgca taccagatag aggagttaat gatactcctg gaatacaaga      480

tcccccgcaa tgaggctgat gggatgccta ttaatgttgg agatggtggt ctctttgaga      540

agaagctgtg gggcctaaag gtgctgcagg agctttcaca gtggacagta aggtccatcc      600

atgaccttcg tttcatttct tctcatcaga ctgggatccc agcacgtggg agccattata      660

ttgctaacaa caagaaaatg tagcagttag tcccttctct cttccttgct ttctcttcta      720

atggaatatg cgtagttccc tggggcctcg ctttcccatc ttaaatttct aaaaacagtt      780

aagacaacag gcattttctt tcttttttct ctgaccacct gcagcctgtt gaaggactac      840

aggtattttc atcaagtagc gttggagaca tacacaaatg ggcatacaag tttagcctgg      900

ggggtgtgat ttgtgtgcgt gcttgcatgt gctgcaggtg taagagagtg ggagcaggga      960

caacgtcctt ccacttcagg gttctaacct ttctaaccca ctaagtaacc tctacaggca     1020

tttaactgcc ttacagacag aatatacata tgttaattct agtcctggat gactcggtct     1080

gagaagattc aatttaaaat cagactcttt agttgattta aactcttaga gaataagaat     1140

aataatggct aacttttatt atcttctata ttaaggcagt atgccaaggg tctttatgta     1200

tattatgtac agcgtttaca accttgtgag caaggtggtg ttactcccat taggtagatg     1260

agaaaacagg ctcacagaga tttggttaag ctcacacagc taacaagtag cacactgagt     1320

ttgaacacag atcattctcc ttgtaaaagc ctatgtgcct ttcactttag aggcttgatc     1380

atgaatcact gcacctcttt gtcacagggt gttggaagat gcatccatgt aatctattcc     1440

catcgctgga aaacagctgc tgttagatgt cctcagaagt cagttgcaaa ttttagcgtt     1500

aaagtcagga tttattgttc atacttggcg gtgaggaggg cagctggaga tcttaagatt     1560

ccattttgga aaatgattag gcccgccaaa cttctgaact ttggaagctg gggatgttta     1620

gtaatacagc ctggttttta agtactcact aaaagttctc aaatattggg ttgggcacgg     1680

cttataccag gttacctcac ttttaattag tgatgcaggc agtgtaaccc aagcatttgt     1740

ggacaatgag tggaatacta aagttaaaaa gtcaaacttt cacctcagat tttctggact     1800

tagtcatgag gagagggtga ggcccactct gttcctactg gagataccag agactctgaa     1860

actatagaat aaagcctctg tgctgcacaa caaaaaaaaa aaaaaaaaaa aaaa           1914


<210>  18
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Phe Thr Glu His Ser Pro Leu Thr Pro His Arg Arg Asp Leu 
1               5                   10                  15      


Cys Ser Arg Ser Ile Trp Leu Ala Arg Lys Ile Arg Ser Asp Leu Thr 
            20                  25                  30          


Ala Leu Thr Glu Ser Tyr Val Lys His Gln Gly Leu Asn Lys Asn Ile 
        35                  40                  45              


Asn Leu Asp Ser Ala Asp Gly Met Pro Val Ala Ser Thr Asp Gln Trp 
    50                  55                  60                  


Ser Glu Leu Thr Glu Ala Glu Arg Leu Gln Glu Asn Leu Gln Ala Tyr 
65                  70                  75                  80  


Arg Thr Phe His Val Leu Leu Ala Arg Leu Leu Glu Asp Gln Gln Val 
                85                  90                  95      


His Phe Thr Pro Thr Glu Gly Asp Phe His Gln Ala Ile His Thr Leu 
            100                 105                 110         


Leu Leu Gln Val Ala Ala Phe Ala Tyr Gln Ile Glu Glu Leu Met Ile 
        115                 120                 125             


Leu Leu Glu Tyr Lys Ile Pro Arg Asn Glu Ala Asp Gly Met Pro Ile 
    130                 135                 140                 


Asn Val Gly Asp Gly Gly Leu Phe Glu Lys Lys Leu Trp Gly Leu Lys 
145                 150                 155                 160 


Val Leu Gln Glu Leu Ser Gln Trp Thr Val Arg Ser Ile His Asp Leu 
                165                 170                 175     


Arg Phe Ile Ser Ser His Gln Thr Gly Ile Pro Ala Arg Gly Ser His 
            180                 185                 190         


Tyr Ile Ala Asn Asn Lys Lys Met 
        195                 200 


<210>  19
<211>  7321
<212>  DNA
<213>  Homo sapiens

<400>  19
ttttgtagat aaatgtgagg attttctcta aatccctctt ctgtttgcta aatctcactg       60

tcactgctaa attcagagca gatagagcct gcgcaatgga ataaagtcct caaaattgaa      120

atgtgacatt gctctcaaca tctcccatct ctctggattt ctttttgctt cattattcct      180

gctaaccaat tcattttcag actttgtact tcagaagcaa tgggaaaaat cagcagtctt      240

ccaacccaat tatttaagtg ctgcttttgt gatttcttga aggtgaagat gcacaccatg      300

tcctcctcgc atctcttcta cctggcgctg tgcctgctca ccttcaccag ctctgccacg      360

gctggaccgg agacgctctg cggggctgag ctggtggatg ctcttcagtt cgtgtgtgga      420

gacaggggct tttatttcaa caagcccaca gggtatggct ccagcagtcg gagggcgcct      480

cagacaggca tcgtggatga gtgctgcttc cggagctgtg atctaaggag gctggagatg      540

tattgcgcac ccctcaagcc tgccaagtca gctcgctctg tccgtgccca gcgccacacc      600

gacatgccca agacccagaa ggaagtacat ttgaagaacg caagtagagg gagtgcagga      660

aacaagaact acaggatgta ggaagaccct cctgaggagt gaagagtgac atgccaccgc      720

aggatccttt gctctgcacg agttacctgt taaactttgg aacacctacc aaaaaataag      780

tttgataaca tttaaaagat gggcgtttcc cccaatgaaa tacacaagta aacattccaa      840

cattgtcttt aggagtgatt tgcaccttgc aaaaatggtc ctggagttgg tagattgctg      900

ttgatctttt atcaataatg ttctatagaa aagaaaaaaa aaatatatat atatatatat      960

cttagtccct gcctctcaag agccacaaat gcatgggtgt tgtatagatc cagttgcact     1020

aaattcctct ctgaatcttg gctgctggag ccattcattc agcaaccttg tctaagtggt     1080

ttatgaattg tttccttatt tgcacttctt tctacacaac tcgggctgtt tgttttacag     1140

tgtctgataa tcttgttagt ctatacccac cacctccctt cataaccttt atatttgccg     1200

aatttggcct cctcaaaagc agcagcaagt cgtcaagaag cacaccaatt ctaacccaca     1260

agattccatc tgtggcattt gtaccaaata taagttggat gcattttatt ttagacacaa     1320

agctttattt ttccacatca tgcttacaaa aaagaataat gcaaatagtt gcaactttga     1380

ggccaatcat ttttaggcat atgttttaaa catagaaagt ttcttcaact caaaagagtt     1440

ccttcaaatg atgagttaat gtgcaaccta attagtaact ttcctctttt tattttttcc     1500

atatagagca ctatgtaaat ttagcatatc aattatacag gatatatcaa acagtatgta     1560

aaactctgtt ttttagtata atggtgctat tttgtagttt gttatatgaa agagtctggc     1620

caaaacggta atacgtgaaa gcaaaacaat aggggaagcc tggagccaaa gatgacacaa     1680

ggggaagggt actgaaaaca ccatccattt gggaaagaag gcaaagtccc cccagttatg     1740

ccttccaaga ggaacttcag acacaaaagt ccactgatgc aaattggact ggcgagtcca     1800

gagaggaaac tgtggaatgg aaaaagcaga aggctaggaa ttttagcagt cctggtttct     1860

ttttctcatg gaagaaatga acatctgcca gctgtgtcat ggactcacca ctgtgtgacc     1920

ttgggcaagt cacttcacct ctctgtgcct cagtttcctc atctgcaaaa tgggggcaat     1980

atgtcatcta cctacctcaa aggggtggta taaggtttaa aaagataaag attcagattt     2040

tttttaccct gggttgctgt aagggtgcaa catcagggcg cttgagttgc tgagatgcaa     2100

ggaattctat aaataaccca ttcatagcat agctagagat tggtgaattg aatgctcctg     2160

acatctcagt tcttgtcagt gaagctatcc aaataactgg ccaactagtt gttaaaagct     2220

aacagctcaa tctcttaaaa cacttttcaa aatatgtggg aagcatttga ttttcaattt     2280

gattttgaat tctgcatttg gttttatgaa tacaaagata agtgaaaaga gagaaaggaa     2340

aagaaaaagg agaaaaacaa agagatttct accagtgaaa ggggaattaa ttactctttg     2400

ttagcactca ctgactcttc tatgcagtta ctacatatct agtaaaacct cgtttaatac     2460

tataaataat attctattca ttttgaaaaa cacaatgatt ccttcttttc taggcaatat     2520

aaggaaagtg atccaaaatt tgaaatatta aaataatatc taataaaaag tcacaaagtt     2580

atcttcttta acaaacttta ctcttattct tagctgtata tacatttttt taaaagtttg     2640

ttaaaatatg cttgactaga gtttccagtt gaaaggcaaa aacttccatc acaacaagaa     2700

atttcccatg cctgctcaga agggtagccc ctagctctct gtgaatgtgt tttatccatt     2760

caactgaaaa ttggtatcaa gaaagtccac tggttagtgt actagtccat catagcctag     2820

aaaatgatcc ctatctgcag atcaagattt tctcattaga acaatgaatt atccagcatt     2880

cagatctttc tagtcacctt agaacttttt ggttaaaagt acccaggctt gattatttca     2940

tgcaaattct atattttaca ttcttggaaa gtctatatga aaaacaaaaa taacatcttc     3000

agtttttctc ccactgggtc acctcaagga tcagaggcca ggaaaaaaaa aaaaaagact     3060

ccctggatct ctgaatatat gcaaaaagaa ggccccattt agtggagcca gcaatcctgt     3120

tcagtcaaca agtattttaa ctctcagtcc aacattattt gaattgagca cctcaagcat     3180

gcttagcaat gttctaatca ctatggacag atgtaaaaga aactatacat catttttgcc     3240

ctctgcctgt tttccagaca tacaggttct gtggaataag atactggact cctcttccca     3300

agatggcact tctttttatt tcttgtcccc agtgtgtacc ttttaaaatt attccctctc     3360

aacaaaactt tataggcagt cttctgcaga cttaacgtgt tttctgtcat agttagatgt     3420

gataattcta agagtgtcta tgacttattt ccttcactta attctatcca cagtcaaaaa     3480

tcccccaagg aggaaagctg aaagatgcac tgccatatta tctttcttaa ctttttccaa     3540

cacataatcc tctccaactg gattataaat aaattgaaaa taactcatta taccaattca     3600

ctattttatt ttttaatgaa ttaaaactag aaaacaaatt gatgcaaacc ctggaagtca     3660

gttgattact atatactaca gcagaatgac tcagatttca tagaaaggag caaccaaaat     3720

gtcacaaccc aaaactttac aagctttgct tcagaattag attgctttat aattcttgaa     3780

tgaggcaatt tcaagatatt tgtaaaagaa cagtaaacat tggtaagaat gagctttcaa     3840

ctcataggct tatttccaat ttaattgacc atactggata cttaggtcaa atttctgttc     3900

tctcttcccc aaataatatt aaagtattat ttgaactttt taagatgagg cagttcccct     3960

gaaaaagtta atgcagctct ccatcagaat ccactcttct agggatatga aaatctctta     4020

acacccaccc tacatacaca gacacacaca cacacacaca cacacacaca cacacacaca     4080

ttcaccctaa ggatccaatg gaatactgaa aagaaatcac ttccttgaaa attttattaa     4140

aaaacaaaca aacaaacaaa aagcctgtcc acccttgaga atccttcctc tccttggaac     4200

gtcaatgttt gtgtagatga aaccatctca tgctctgtgg ctccagggtt tctgttacta     4260

ttttatgcac ttgggagaag gcttagaata aaagatgtag cacattttgc tttcccattt     4320

attgtttggc cagctatgcc aatgtggtgc tattgtttct ttaagaaagt acttgactaa     4380

aaaaaaaaga aaaaaagaaa aaaaagaaag catagacata tttttttaaa gtataaaaac     4440

aacaattcta tagatagatg gcttaataaa atagcattag gtctatctag ccaccaccac     4500

ctttcaactt tttatcactc acaagtagtg tactgttcac caaattgtga atttgggggt     4560

gcaggggcag gagttggaaa ttttttaaag ttagaaggct ccattgtttt gttggctctc     4620

aaacttagca aaattagcaa tatattatcc aatcttctga acttgatcaa gagcatggag     4680

aataaacgcg ggaaaaaaga tcttataggc aaatagaaga atttaaaaga taagtaagtt     4740

ccttattgat ttttgtgcac tctgctctaa aacagatatt cagcaagtgg agaaaataag     4800

aacaaagaga aaaaatacat agatttacct gcaaaaaata gcttctgcca aatccccctt     4860

gggtattctt tggcatttac tggtttatag aagacattct cccttcaccc agacatctca     4920

aagagcagta gctctcatga aaagcaatca ctgatctcat ttgggaaatg ttggaaagta     4980

tttccttatg agatgggggt tatctactga taaagaaaga atttatgaga aattgttgaa     5040

agagatggct aacaatctgt gaagattttt tgtttcttgt ttttgttttt tttttttttt     5100

tactttatac agtctttatg aatttcttaa tgttcaaaat gacttggttc ttttcttctt     5160

tttttatatc agaatgagga ataataagtt aaacccacat agactcttta aaactatagg     5220

ctagatagaa atgtatgttt gacttgttga agctataatc agactattta aaatgttttg     5280

ctatttttaa tcttaaaaga ttgtgctaat ttattagagc agaacctgtt tggctctcct     5340

cagaagaaag aatctttcca ttcaaatcac atggctttcc accaatattt tcaaaagata     5400

aatctgattt atgcaatggc atcatttatt ttaaaacaga agaattgtga aagtttatgc     5460

ccctcccttg caaagaccat aaagtccaga tctggtaggg gggcaacaac aaaaggaaaa     5520

tgttgttgat tcttggtttt ggattttgtt ttgttttcaa tgctagtgtt taatcctgta     5580

gtacatattt gcttattgct attttaatat tttataagac cttcctgtta ggtattagaa     5640

agtgatacat agatatcttt tttgtgtaat ttctatttaa aaaagagaga agactgtcag     5700

aagctttaag tgcatatggt acaggataaa gatatcaatt taaataacca attcctatct     5760

ggaacaatgc ttttgttttt taaagaaacc tctcacagat aagacagagg cccaggggat     5820

ttttgaagct gtctttattc tgcccccatc ccaacccagc ccttattatt ttagtatctg     5880

cctcagaatt ttatagaggg ctgaccaagc tgaaactcta gaattaaagg aacctcactg     5940

aaaacatata tttcacgtgt tccctctttt tttttttcct ttttgtgaga tggggtctcg     6000

cactgtcccc caggctggag tgcagtggca tgatctcggc tcactgcaac ctccacctcc     6060

tgggtttaag cgattctcct gcctcagcct cctgagtagc tgggattaca ggcacccacc     6120

actatgcccg gctaattttt tggattttta atagagacgg ggttttacca tgttggccag     6180

gttggtctca aactcctgac cttgtgattt gcccgcctca gcctcccaaa ttgctgggat     6240

tacaggcatg agccaccaca ccctgcccat gtgttccctc ttaatgtatg attacatgga     6300

tcttaaacat gatccttctc tcctcattct tcaactatct ttgatggggt ctttcaaggg     6360

gaaaaaaatc caagcttttt taaagtaaaa aaaaaaaaag agaggacaca aaaccaaatg     6420

ttactgctca actgaaatat gagttaagat ggagacagag tttctcctaa taaccggagc     6480

tgaattacct ttcactttca aaaacatgac cttccacaat ccttagaatc tgcctttttt     6540

tatattactg aggcctaaaa gtaaacatta ctcattttat tttgcccaaa atgcactgat     6600

gtaaagtagg aaaaataaaa acagagctct aaaatccctt tcaagccacc cattgacccc     6660

actcaccaac tcatagcaaa gtcacttctg ttaatccctt aatctgattt tgtttggata     6720

tttatcttgt acccgctgct aaacacactg caggagggac tctgaaacct caagctgtct     6780

acttacatct tttatctgtg tctgtgtatc atgaaaatgt ctattcaaaa tatcaaaacc     6840

tttcaaatat cacgcagctt atattcagtt tacataaagg ccccaaatac catgtcagat     6900

ctttttggta aaagagttaa tgaactatga gaattgggat tacatcatgt attttgcctc     6960

atgtattttt atcacactta taggccaagt gtgataaata aacttacaga cactgaatta     7020

atttcccctg ctactttgaa accagaaaat aatgactggc cattcgttac atctgtctta     7080

gttgaaaagc atatttttta ttaaattaat tctgattgta tttgaaatta ttattcaatt     7140

cacttatggc agaggaatat caatcctaat gacttctaaa aatgtaacta attgaatcat     7200

tatcttacat ttactgttta ataagcatat tttgaaaatg tatggctaga gtgtcataat     7260

aaaatggtat atctttcttt agtaattaca ttaaaattag tcatgtttga ttaattagtt     7320

c                                                                     7321


<210>  20
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
    130                 135                 140                 


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
145                 150             


<210>  21
<211>  1892
<212>  DNA
<213>  Homo sapiens

<400>  21
actggccgct gagagaagaa tcgggtggag cagagagcag ctgctgcagg gcagacagcc       60

ggacccccaa atctgcacgt accagcagtc agccgcccca cgcagggacc ggcttacccc      120

tcgctccccg ccctcactca ctttctcccg ccctcggccc ggcctcccag ctctctactt      180

cgcgtgtcta caaactcaac tcccggtttc cgtgcctctc caccgctcga gttctctact      240

ctccatatcc gaggggcccc tcccagcatc tacccccctc ccaacctcgg gggacctagc      300

caagctaggg gggactggat ccgacgggtg gagcagccag gtgagccccg aaaggtgggg      360

cggggcaggg gcgctcccag ccccaccccg ggatctggtg acgctggggc tggaatttga      420

caccggacgg ctgcggcggc gggcaggagg ctgctgaggg atggagttgg gcccggcccc      480

cagacaaggc ccgggggctc cgccagcagc aggtccctcg ggccccagcc ctcgctgcca      540

cccgggcctg gagccccaca cccgagggtg cagactggct gccaaggcca cacttttggc      600

taaaagaggc actgccaggt gtacagtcct gggcatgcgc tgtttgagct tcgggggaga      660

gcccagcact ggtccccgga aaggtgccta gaagaacaag gtgcaggacc ccgtgctgcc      720

tcaacaggag ggtgggggaa cagctcaaca atggctgatg ggcgctcctg gtgttgatag      780

agatggaact tggacttgga ggcctctcca cgctgtccca ctgcccctgg cctaggcggc      840

agcctgccct gtggcccacc ctggccgctc tggctctgct gagcagcgtc gcagaggcct      900

ccctgggctc cgcgccccgc agccctgccc cccgcgaagg ccccccgcct gtcctggcgt      960

cccccgccgg ccacctgccg gggggacgca cggcccgctg gtgcagtgga agagcccggc     1020

ggccgccgcc gcagccttct cggcccgcgc ccccgccgcc tgcaccccca tctgctcttc     1080

cccgcggggg ccgcgcggcg cgggctgggg gcccgggcag ccgcgctcgg gcagcggggg     1140

cgcggggctg ccgcctgcgc tcgcagctgg tgccggtgcg cgcgctcggc ctgggccacc     1200

gctccgacga gctggtgcgt ttccgcttct gcagcggctc ctgccgccgc gcgcgctctc     1260

cacacgacct cagcctggcc agcctactgg gcgccggggc cctgcgaccg cccccgggct     1320

cccggcccgt cagccagccc tgctgccgac ccacgcgcta cgaagcggtc tccttcatgg     1380

acgtcaacag cacctggaga accgtggacc gcctctccgc caccgcctgc ggctgcctgg     1440

gctgagggct cgctccaggg ctttgcagac tggaccctta ccggtggctc ttcctgcctg     1500

ggaccctccc gcagagtccc actagccagc ggcctcagcc agggacgaag gcctcaaagc     1560

tgagaggccc ctaccggtgg gtgatggata tcatccccga acaggtgaag ggacaactga     1620

ctagcagccc cagagccctc accctgcgga tcccagccta aaagacacca gagacctcag     1680

ctatggagcc cttcggaccc acttctcaca gactctggca ctggccaggc ctcgaacctg     1740

ggacccctcc tctgatgaac actacagtgg ctgaggcatc agcccccgcc caggccctgt     1800

agggacagca tttgaaggac acatattgca gttgcttggt tgaaagtgcc tgtgctggaa     1860

ctggcctgta ctcactcatg ggagctggcc cc                                   1892


<210>  22
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Leu Gly Leu Gly Gly Leu Ser Thr Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Arg Gln Pro Ala Leu Trp Pro Thr Leu Ala Ala Leu Ala Leu 
            20                  25                  30          


Leu Ser Ser Val Ala Glu Ala Ser Leu Gly Ser Ala Pro Arg Ser Pro 
        35                  40                  45              


Ala Pro Arg Glu Gly Pro Pro Pro Val Leu Ala Ser Pro Ala Gly His 
    50                  55                  60                  


Leu Pro Gly Gly Arg Thr Ala Arg Trp Cys Ser Gly Arg Ala Arg Arg 
65                  70                  75                  80  


Pro Pro Pro Gln Pro Ser Arg Pro Ala Pro Pro Pro Pro Ala Pro Pro 
                85                  90                  95      


Ser Ala Leu Pro Arg Gly Gly Arg Ala Ala Arg Ala Gly Gly Pro Gly 
            100                 105                 110         


Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln 
        115                 120                 125             


Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu Leu 
    130                 135                 140                 


Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser Pro 
145                 150                 155                 160 


His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro 
                165                 170                 175     


Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr Arg 
            180                 185                 190         


Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr Val 
        195                 200                 205             


Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
    210                 215                 220 


