                         SEQUENCE LISTING

<110>  Centrose LLC
 
<120>  EXTRACELLULAR TARGETED DRUG CONJUGATES

<130>  3718375.00021

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  178
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Ser Pro Ser Gly Arg Leu Cys Leu Leu Thr Ile Val Gly Leu Ile 
1               5                   10                  15      


Leu Pro Thr Arg Gly Gln Thr Leu Lys Asp Thr Thr Ser Ser Ser Ser 
            20                  25                  30          


Ala Asp Ser Thr Ile Met Asp Ile Gln Val Pro Thr Arg Ala Pro Asp 
        35                  40                  45              


Ala Val Tyr Thr Glu Leu Gln Pro Thr Ser Pro Thr Pro Thr Trp Pro 
    50                  55                  60                  


Ala Asp Glu Thr Pro Gln Pro Gln Thr Gln Thr Gln Gln Leu Glu Gly 
65                  70                  75                  80  


Thr Asp Gly Pro Leu Val Thr Asp Pro Glu Thr His Lys Ser Thr Lys 
                85                  90                  95      


Ala Ala His Pro Thr Asp Asp Thr Thr Thr Leu Ser Glu Arg Pro Ser 
            100                 105                 110         


Pro Ser Thr Asp Val Gln Thr Asp Pro Gln Thr Leu Lys Pro Ser Gly 
        115                 120                 125             


Phe His Glu Asp Asp Pro Phe Phe Tyr Asp Glu His Thr Leu Arg Lys 
    130                 135                 140                 


Arg Gly Leu Leu Val Ala Ala Val Leu Phe Ile Thr Gly Ile Ile Ile 
145                 150                 155                 160 


Leu Thr Ser Gly Lys Cys Arg Gln Leu Ser Arg Leu Cys Arg Asn His 
                165                 170                 175     


Cys Arg 
        


<210>  2
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP001

<400>  2

Leu Lys Asp Thr Thr Ser Ser Ser Ser Ala Asp Ser Thr Ile Met Asp 
1               5                   10                  15      


Cys 
    


<210>  3
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP004

<400>  3

Ser Ser Ser Ala Asp Ser Thr Ile Met Asp Ile Gln Val Pro Cys 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP005

<400>  4

Met Asp Ile Gln Val Pro Thr Arg Ala Pro Asp Ala Val Tyr Cys 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP006

<400>  5

Ala Pro Asp Ala Val Tyr Thr Glu Leu Gln Pro Thr Ser Pro Cys 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP007

<400>  6

Leu Gln Pro Thr Ser Pro Thr Pro Thr Trp Pro Ala Asp Glu Cys 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP008

<400>  7

Thr Trp Pro Ala Asp Glu Thr Pro Gln Pro Gln Thr Gln Thr Cys 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP009

<400>  8

Gln Pro Gln Thr Gln Thr Gln Gln Leu Glu Gly Thr Asp Gly Cys 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP010

<400>  9

Leu Glu Gly Thr Asp Gly Pro Leu Val Thr Asp Pro Glu Thr Cys 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP011

<400>  10

Val Thr Asp Pro Glu Thr His Lys Ser Thr Lys Ala Ala His Cys 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP012

<400>  11

Ser Thr Lys Ala Ala His Pro Thr Asp Asp Thr Thr Thr Leu Cys 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP013

<400>  12

Asp Asp Thr Thr Thr Leu Ser Glu Arg Pro Ser Pro Ser Thr Cys 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP014

<400>  13

Arg Pro Ser Pro Ser Thr Asp Val Gln Thr Asp Pro Gln Thr Cys 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP015

<400>  14

Gln Thr Asp Pro Gln Thr Leu Lys Pro Ser Gly Phe His Glu Cys 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP016

<400>  15

Pro Ser Gly Phe His Glu Asp Asp Pro Phe Phe Tyr Asp Glu Cys 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP017

<400>  16

Asp Glu Pro Phe Phe Tyr Asp Glu His Thr Leu Arg Lys Arg Cys 
1               5                   10                  15  


<210>  17
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENP018

<400>  17

Pro Thr Arg Ala Pro Asp Ala Val Tyr Thr Glu Leu Gln Cys 
1               5                   10                  


<210>  18
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized: universal primer

<400>  18
ctaatacgac tcactatagg gc                                                22


<210>  19
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized: IgG1/IgG2A primer

<400>  19
ctcaattttc ttgtccacct tggtgc                                            26


<210>  20
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized: IgG2b primer

<400>  20
ctcaagtttt ttgtccaccg tggtgc                                            26


<210>  21
<211>  827
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized: M53 HC coding sequence including signal peptide, 
       variable domain, and portion of constant domain

<400>  21
tgggccctct agatgcatgc tcgagcggcc gccagtgtga tggataacgg atccgaattg       60

ccccttctaa tacgactcac tatagggcaa gcagtggtat caacgcagag tacatgggga      120

ggcagagaac tttagccctg tcttcccttt tagtgttcag cactgacaat ataacattga      180

acatgctgtc ggggctgaag tgggttttct ttgttgtttt ttatcaaggt gtgcattgtg      240

aggtgcagct tgttgagtct ggtggaggat tggtgcagcc taaagggaca ttgaaactct      300

catgtgccgc ctctggattc agcttcaata cccatgccat gaactgggtc cgccaggctc      360

caggaaagag tttggaatgg gttgctcgca caatgagtaa aagtaataat tatgcaacat      420

attatgcaga ttcagtgaaa gatagattca tcatctccag agatgattca caaagcatgc      480

tctatctgca aatgaacaac ttgaaaactg aggacacagc catgtattac tgtgtgaggg      540

acgaccctaa gagaggtatg gactactggg gtcaaggaac ctcagtcacc gtctcctcag      600

ccaaaacgac acccccatct gtctatccac tggcccctgg atctgctgcc caaactaact      660

ccatggtgac cctgggatgc ctggtcaagg gctatttccc tgagccagtg acagtgacct      720

ggaactctgg atccctgtcc agcggtgtgc acaccttccc agctgtcctg cagtctgacc      780

tctacactct gagcagctca gtgactgtcc cctccagcac ctggccc                    827


<210>  22
<211>  787
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized: M53 LC coding sequence including signal peptide, 
       variable domain, and portion of constant domain

<400>  22
gggagactcc tatagggcga ttgggccctc tagatgcatg ctcgagcggc cgccagtgtg       60

atggatatcg gatccgaatt gccccttcta atacgactca ctatagggca agcagtggta      120

tcaacgcaga gtacatgggg agacaggcag gggaagcaag atggattcac aggcccaggt      180

tcttatgtta ctgctgctat gggtatctgg tacctgtggg ggcattgtga tgtcacagtc      240

tccatcctcc ctagctgtgt cagttggaga gaaggttact atgagctgca agcccagtca      300

gagcctttta tatagtcgca atcaaaagat ctacttggcc tggtaccagc agaaaccagg      360

gcagtctcct aaactgctga tttactgggc atccactagg gaatctgggg tccctgatcg      420

cttcacaggc agtggatctg ggacagattt cactctcatc atcagcagtg tgagggctga      480

agacctggca gtttattact gtcagcaata ttataactat cctctcacgt tcggtgctgg      540

gaccaagctg gagctgaaac gggctgatgc tgcaccaact gtatccatct tcccaccatc      600

cagtgagcag ttaacatctg gaggtgcctc agtcgtgtgc ttcttgaaca acttctaccc      660

caaagacatc aatgtcaagt ggaagattga tggcagtgaa cgacaaaatg gcgtcctgaa      720

cagttggact gatcaggaca gcaaagacag cacctacagc atgagcagca ccctcacgtt      780

gaccaag                                                                787


<210>  23
<211>  450
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: chimeric M53-HC

<400>  23

Glu Cys Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Thr Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr His 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Thr Met Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Ile Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Asp Pro Lys Arg Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  24
<211>  220
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: chimeric M53-LC

<400>  24

Gly Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Pro Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Arg Asn Gln Lys Ile Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile 
65                  70                  75                  80  


Ile Ser Ser Val Arg Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  25
<211>  1443
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized: chimeric M53-HC coding sequence including signal 
       sequence

<400>  25
atggacagca aaggttcgtc gcagaaaggg tcccgcctgc tcctgctgct ggtggtgtca       60

aatctactct tgtgccaggg tgtggtctcc gagtgccagc ttgttgagtc tggtggagga      120

ttggtgcagc ctaaagggac attgaaactc tcatgtgccg cctctggatt cagcttcaat      180

acccatgcca tgaactgggt ccgccaggct ccaggaaaga gtttggaatg ggttgctcgc      240

acaatgagta aaagtaataa ttatgcaaca tattatgcag attcagtgaa agatagattc      300

atcatctcca gagatgattc acaaagcatg ctctatctgc aaatgaacaa cttgaaaact      360

gaggacacag ccatgtatta ctgtgtgagg gacgacccta agagaggtat ggactactgg      420

ggtcaaggaa cctcagtcac cgtctcctca gctagcacca agggcccatc ggtcttcccc      480

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag      540

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg      600

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc      660

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc      720

aacaccaagg tggacaagag agttgagccc aaatcttgtg acaaaactca cacatgccca      780

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      840

aaggacaccc tcatgatctc ccggacccct gaggtcacgt gcgtggtggt ggacgtgagc      900

cacgaagacc ccgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      960

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1020

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1080

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1140

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1200

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1260

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1320

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1380

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1440

tga                                                                   1443


<210>  26
<211>  723
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized: chimeric M53-LC coding sequence including signal 
       sequence

<400>  26
atggattcac aggcccaggt tcttatgtta ctgctgctat gggtatctgg tacctgtggg       60

ggcattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact      120

atgagctgca agcccagtca gagcctttta tatagtcgca atcaaaagat ctacttggcc      180

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      240

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcatc      300

atcagcagtg tgagggctga agacctggca gtttattact gtcagcaata ttataactat      360

cctctcacgt tcggtgctgg gaccaagctg gagctgaaac gtaccgtggc tgcaccatct      420

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      480

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      540

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      600

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      660

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      720

tag                                                                    723


<210>  27
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: chimeric M53-HC signal peptide

<400>  27

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Cys Gln Gly Val Val Ser 
            20                  25                  30  


<210>  28
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: chimeric M53-LC signal peptide

<400>  28

Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly 
            20  


<210>  29
<211>  833
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized: CENscFv003 [Cysteine on heavy chain] coding sequence

<400>  29
aggaggtaaa acatatgaaa caaagcacca ttgcactggc actgctgccg ctgctgttta       60

cgccggtcac gaaggcggaa tgccagctgg ttgagtccgg cggtggtctg gtgcaaccga      120

aaggtaccct gaagttgagc tgtgccgcct cgggcttttc gttcaacacc cacgcgatga      180

actgggtccg ccaagcgcct ggcaagagcc tggagtgggt tgcgcgtacc atgagcaaga      240

gcaataacta tgctacctac tatgccgaca gcgtcaaaga ccgtttcatt atcagccgcg      300

atgacagcca gagcatgctg tatttgcaga tgaataatct gaaaaccgag gacactgcaa      360

tgtattactg tgtgcgtgat gatccgaagc gcggcatgga ctactggggt cagggcacca      420

gcgttacggt gagctctggt ggtggcggca gcggtggtgg cggtagcggt ggcggtggca      480

gcggtattgt tatgtctcag agcccgagct ccctggcggt tagcgtgggt gaaaaagtga      540

cgatgagctg caaaccgagc caatctctgt tgtacagccg caaccagaag atctatctgg      600

cgtggtacca acaaaagccg ggtcagagcc caaaactgct gatctattgg gcatccacgc      660

gtgagtccgg tgtcccggat cgtttcacgg gttctggttc cggcaccgac ttcactctga      720

tcattagcag cgttcgtgcg gaggatctgg cagtgtacta ttgccagcaa tactacaatt      780

acccgctgac ctttggtgct ggtaccaaat tggaactgaa gtaatgactc gag             833


<210>  30
<211>  269
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: CENscFv003

<400>  30

Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Glu Cys Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Lys Gly Thr Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Ser Phe Asn Thr His Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Ser Leu Glu Trp Val Ala Arg Thr Met Ser Lys Ser Asn Asn Tyr Ala 
65                  70                  75                  80  


Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Ile Ile Ser Arg Asp 
                85                  90                  95      


Asp Ser Gln Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu 
            100                 105                 110         


Asp Thr Ala Met Tyr Tyr Cys Val Arg Asp Asp Pro Lys Arg Gly Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile Val Met 
145                 150                 155                 160 


Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly Glu Lys Val Thr 
                165                 170                 175     


Met Ser Cys Lys Pro Ser Gln Ser Leu Leu Tyr Ser Arg Asn Gln Lys 
            180                 185                 190         


Ile Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Ser Ser Val 
225                 230                 235                 240 


Arg Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr 
                245                 250                 255     


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            260                 265                 


<210>  31
<211>  237
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: M53-HC (CEN-AB-010-HC)

<400>  31

Met Leu Ser Gly Leu Lys Trp Val Phe Phe Val Val Phe Tyr Gln Gly 
1               5                   10                  15      


Val His Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Lys Gly Thr Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe 
        35                  40                  45              


Asn Thr His Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Thr Met Ser Lys Ser Asn Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Asp Arg Phe Ile Ile Arg Ala Asp Asp Ser 
                85                  90                  95      


Gln Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Val Arg Asp Asp Pro Lys Arg Gly Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 
145                 150                 155                 160 


Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
        195                 200                 205             


Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
    210                 215                 220                 


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu 
225                 230                 235         


<210>  32
<211>  237
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: M53-LC (CEN-AB-010-LC)

<400>  32

Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Gly Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Pro Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Arg Asn Gln Lys Ile Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Ile Ile Ser Ser Val Arg Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys 
145                 150                 155                 160 


Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile 
                165                 170                 175     


Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His 
    210                 215                 220                 


Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg 
225                 230                 235         


<210>  33
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: M53-HC CDR1

<400>  33

Ser Phe Asn Thr His Ala Met Asn 
1               5               


<210>  34
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: M53-HC CDR2

<400>  34

Thr Met Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


<210>  35
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: M53-HC CDR3

<400>  35

Val Arg Asp Asp Pro Lys Arg Gln 
1               5               


<210>  36
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: M53-LC CDR1

<400>  36

Lys Pro Ser Gln Ser Leu Leu Tyr Ser Arg Asn Gln Lys Ile Tyr Leu 
1               5                   10                  15      


<210>  37
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: M53-LC CDR2

<400>  37

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  38
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized: M53-LC CDR3

<400>  38

Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe 
1               5                   10      


