                         SEQUENCE LISTING

<110>  Universit de Montral
       Nanci, Antonio
       Moffatt, Pierre
       Mazen, Rima
 
<120>  COMPOSITIONS, DIAGNOSTIC METHODS USING EPITHELIAL EXTRACELLULAR 
       MATRIX PROTEINS

<130>  P1634PC00

<150>  61453600
<151>  2011-03-17

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Ser Thr Ile Leu Leu Phe Cys Leu Leu Gly Ser Thr Arg Ser 
1               5                   10                  15      


Leu Pro Gln Leu Lys Pro Ala Leu Gly Leu Pro Pro Thr Lys Leu Ala 
            20                  25                  30          


Pro Asp Gln Gly Thr Leu Pro Asn Gln Gln Gln Ser Asn Gln Val Phe 
        35                  40                  45              


Pro Ser Leu Ser Leu Ile Pro Leu Thr Gln Met Leu Thr Leu Gly Pro 
    50                  55                  60                  


Asp Leu His Leu Leu Asn Pro Ala Ala Gly Met Thr Pro Gly Thr Gln 
65                  70                  75                  80  


Thr His Pro Leu Thr Leu Gly Gly Leu Asn Val Gln Gln Gln Leu His 
                85                  90                  95      


Pro His Val Leu Pro Ile Phe Val Thr Gln Leu Gly Ala Gln Gly Thr 
            100                 105                 110         


Ile Leu Ser Ser Glu Glu Leu Pro Gln Ile Phe Thr Ser Leu Ile Ile 
        115                 120                 125             


His Ser Leu Phe Pro Gly Gly Ile Leu Pro Thr Ser Gln Ala Gly Ala 
    130                 135                 140                 


Asn Pro Asp Val Gln Asp Gly Ser Leu Pro Ala Gly Gly Ala Gly Val 
145                 150                 155                 160 


Asn Pro Ala Thr Gln Gly Thr Pro Ala Gly Arg Leu Pro Thr Pro Ser 
                165                 170                 175     


Gly Thr Asp Asp Asp Phe Ala Val Thr Thr Pro Ala Gly Ile Gln Arg 
            180                 185                 190         


Ser Thr His Ala Ile Glu Glu Ala Thr Thr Glu Ser Ala Asn Gly Ile 
        195                 200                 205             


Gln 
    


<210>  2
<211>  213
<212>  PRT
<213>  Mus musculus

<400>  2

Met Lys Thr Met Ile Leu Leu Leu Cys Leu Leu Gly Ser Ala Gln Ser 
1               5                   10                  15      


Leu Pro Lys Gln Leu Asn Pro Ala Ser Gly Val Pro Ala Thr Lys Pro 
            20                  25                  30          


Thr Pro Gly Gln Val Thr Pro Leu Pro Gln Gln Gln Pro Asn Gln Val 
        35                  40                  45              


Phe Pro Ser Ile Ser Leu Ile Pro Leu Thr Gln Leu Leu Thr Leu Gly 
    50                  55                  60                  


Ser Asp Leu Pro Leu Phe Asn Pro Ala Ala Gly Pro His Gly Ala His 
65                  70                  75                  80  


Thr Leu Pro Phe Thr Leu Gly Pro Leu Asn Gly Gln Gln Gln Leu Gln 
                85                  90                  95      


Pro Gln Met Leu Pro Ile Ile Val Ala Gln Leu Gly Ala Gln Gly Ala 
            100                 105                 110         


Leu Leu Ser Ser Glu Glu Leu Pro Leu Ala Ser Gln Ile Phe Thr Gly 
        115                 120                 125             


Leu Leu Ile His Pro Leu Phe Pro Gly Ala Ile Pro Pro Ser Gly Gln 
    130                 135                 140                 


Ala Gly Thr Lys Pro Asp Val Gln Asn Gly Val Leu Pro Thr Arg Gln 
145                 150                 155                 160 


Ala Gly Ala Lys Ala Val Asn Gln Gly Thr Thr Pro Gly His Val Thr 
                165                 170                 175     


Thr Pro Gly Val Thr Asp Asp Asp Asp Tyr Glu Met Ser Thr Pro Ala 
            180                 185                 190         


Gly Leu Arg Arg Ala Thr His Thr Thr Glu Gly Thr Thr Ile Asp Pro 
        195                 200                 205             


Pro Asn Arg Thr Gln 
    210             


<210>  3
<211>  212
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Lys Thr Val Val Leu Leu Leu Cys Leu Leu Gly Ser Ala Gln Ser 
1               5                   10                  15      


Leu Pro Arg Gln Leu Ser Pro Ala Leu Gly Ala Pro Ala Thr Lys Pro 
            20                  25                  30          


Thr Pro Gly Gln Val Thr Pro Leu Thr Gln Gln Gln Pro Asn Gln Val 
        35                  40                  45              


Phe Pro Ser Ile Ser Leu Ile Pro Leu Thr Gln Leu Leu Thr Leu Gly 
    50                  55                  60                  


Ser Asp Leu Pro Leu Phe Asn Pro Ala Thr Met Pro His Gly Thr Gln 
65                  70                  75                  80  


Thr Leu Pro Phe Thr Leu Gly Pro Leu Asn Gly Gln Gln Gln Leu Gln 
                85                  90                  95      


Pro Gln Met Leu Pro Ile Ile Val Ala Gln Leu Gly Ala Gln Gly Ala 
            100                 105                 110         


Leu Leu Ser Ser Glu Glu Leu Pro Leu Ala Ser Gln Ile Phe Thr Gly 
        115                 120                 125             


Leu Leu Ile His Pro Leu Phe Pro Gly Ala Ile Gln Pro Ser Gly Gln 
    130                 135                 140                 


Thr Gly Ala Lys Pro Asp Val Gln Asn Gly Ala Leu Pro Thr Arg Gln 
145                 150                 155                 160 


Ala Gly Ala Ser Pro Ala Asn Gln Ala Thr Thr Pro Gly His Thr Thr 
                165                 170                 175     


Pro Ala Val Thr Asp Asp Asp Asp Tyr Glu Met Ser Thr Pro Ala Gly 
            180                 185                 190         


Leu Gln Arg Ala Thr His Thr Thr Glu Gly Thr Thr Met Asp Pro Pro 
        195                 200                 205             


Asn Arg Thr Lys 
    210         


<210>  4
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Phe Leu Ile Leu Ala Gly Leu Leu Ser Thr Ala Thr Ala Leu 
1               5                   10                  15      


Pro Ile Pro Leu Glu Gln Tyr Ala Glu Ser Ser Ser Glu Gln Arg Phe 
            20                  25                  30          


Ile Phe Tyr Pro Pro Gln Val Pro Pro Phe Phe Pro Gln Val Leu Phe 
        35                  40                  45              


Pro Leu Pro Pro Gln Pro Pro Leu Ile Ser Ile Pro Phe Pro Phe Pro 
    50                  55                  60                  


Tyr Asn Pro Asn Gln Val Leu Thr Pro Asn Asp Leu Ile Ala Leu Leu 
65                  70                  75                  80  


Ile Ala Ile Leu Asn Gln Leu Gly Asn Phe Ser Gly Thr 
                85                  90              


<210>  5
<211>  90
<212>  PRT
<213>  Mus musculus

<400>  5

Met Gln Leu Phe Leu Leu Ala Ala Leu Leu Ser Ala Ala Ala Ala Leu 
1               5                   10                  15      


Pro Ile Pro Leu Gly Gln Ser Gly Gly Ser Ser Ser Glu Gln Arg Phe 
            20                  25                  30          


Asn Leu Tyr Ala Pro Gln Ile Leu Pro Phe Phe Pro Pro Phe Pro Leu 
        35                  40                  45              


Pro Gln Ala Pro Leu Ile Pro Ile Pro Phe Pro Phe Pro Phe Asp Pro 
    50                  55                  60                  


Asn Gln Val Leu Thr Pro Asn Gln Leu Leu Glu Leu Ile Thr Ser Ile 
65                  70                  75                  80  


Leu Asn Gln Leu Gln Gly Phe Leu Gly Arg 
                85                  90  


<210>  6
<211>  90
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Lys Leu Leu Leu Leu Ala Ser Leu Leu Ser Ala Ala Ala Ala Leu 
1               5                   10                  15      


Pro Ile Pro Leu Gly Gln Ser Gly Gly Ser Ser Ser Glu Gln Arg Phe 
            20                  25                  30          


Asn Leu Tyr Pro Pro Gln Ile Leu Pro Phe Phe Pro Gln Phe Pro Leu 
        35                  40                  45              


Pro Gln Ala Pro Leu Ile Pro Ile Pro Phe Pro Phe Pro Phe Asp Pro 
    50                  55                  60                  


Asn Gln Val Leu Thr Pro Asn Gln Leu Leu Ala Leu Ile Thr Ser Ile 
65                  70                  75                  80  


Leu Asn Gln Leu Gln Gly Phe Leu Gly Arg 
                85                  90  


<210>  7
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Lys Val Leu Leu Leu Ile Thr Ala Ile Leu Ala Val Ala Val 
1               5                   10                  15      


Gly Phe Pro Val Ser Gln Asp Gln Glu Arg Glu Lys Arg Ser Ile Ser 
            20                  25                  30          


Asp Ser Asp Glu Leu Ala Ser Gly Phe Phe Val Phe Pro Tyr Pro Tyr 
        35                  40                  45              


Pro Phe Arg Pro Leu Pro Pro Ile Pro Phe Pro Arg Phe Pro Trp Phe 
    50                  55                  60                  


Arg Arg Asn Phe Pro Ile Pro Ile Pro Glu Ser Ala Pro Thr Thr Pro 
65                  70                  75                  80  


Leu Pro Ser Glu Lys 
                85  


<210>  8
<211>  84
<212>  PRT
<213>  Mus musculus

<400>  8

Met Lys Thr Leu Leu Leu Leu Ala Ala Ile Val Ala Val Thr Ala Cys 
1               5                   10                  15      


Leu Pro Val Pro Lys Asp Gln Glu Arg Glu Lys Arg Ser Ala Ser Asp 
            20                  25                  30          


Ser Asp Ser Asp Glu Phe Pro Leu Arg Ile Pro Phe Pro Pro Tyr Gly 
        35                  40                  45              


Tyr Pro Phe Gly Thr Tyr Pro Pro Phe Leu Asn Gln Gly Tyr Pro Trp 
    50                  55                  60                  


Tyr Tyr Tyr Tyr Tyr Pro Pro Phe Pro Leu Pro Phe Thr Pro Pro Pro 
65                  70                  75                  80  


Thr Ala Asp Pro 
                


<210>  9
<211>  81
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Met Lys Ala Leu Leu Leu Leu Ser Ala Ile Leu Ala Ile Thr Ala Cys 
1               5                   10                  15      


Leu Pro Val Pro Glu Asp Gln Glu Arg Glu Lys Arg Ser Ala Ser Asp 
            20                  25                  30          


Glu Leu Pro Glu Arg Ile Ser Phe Pro Pro Phe Gly Pro Pro Phe Gly 
        35                  40                  45              


Gly Tyr Pro Pro Phe Phe Asn Gln Gly Asn Pro Trp Tyr Tyr Tyr Tyr 
    50                  55                  60                  


Tyr Tyr Asn Pro Phe Leu Val Pro Ile Ile Pro Pro Thr Thr Arg Thr 
65                  70                  75                  80  


Pro 
    


<210>  10
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Ile Ile Ile Leu Leu Gly Phe Leu Gly Ala Thr Leu Ser Ala 
1               5                   10                  15      


Pro Leu Ile Pro Gln Arg Leu Met Ser Ala Ser Asn Ser Asn Glu Leu 
            20                  25                  30          


Leu Leu Asn Leu Asn Asn Gly Gln Leu Leu Pro Leu Gln Leu Gln Gly 
        35                  40                  45              


Pro Leu Asn Ser Trp Ile Pro Pro Phe Ser Gly Ile Leu Gln Gln Gln 
    50                  55                  60                  


Gln Gln Ala Gln Ile Pro Gly Leu Ser Gln Phe Ser Leu Ser Ala Leu 
65                  70                  75                  80  


Asp Gln Phe Ala Gly Leu Leu Pro Asn Gln Ile Pro Leu Thr Gly Glu 
                85                  90                  95      


Ala Ser Phe Ala Gln Gly Ala Gln Ala Gly Gln Val Asp Pro Leu Gln 
            100                 105                 110         


Leu Gln Thr Pro Pro Gln Thr Gln Pro Gly Pro Ser His Val Met Pro 
        115                 120                 125             


Tyr Val Phe Ser Phe Lys Met Pro Gln Glu Gln Gly Gln Met Phe Gln 
    130                 135                 140                 


Tyr Tyr Pro Val Tyr Met Val Leu Pro Trp Glu Gln Pro Gln Gln Thr 
145                 150                 155                 160 


Val Pro Arg Ser Pro Gln Gln Thr Arg Gln Gln Gln Tyr Glu Glu Gln 
                165                 170                 175     


Ile Pro Phe Tyr Ala Gln Phe Gly Tyr Ile Pro Gln Leu Ala Glu Pro 
            180                 185                 190         


Ala Ile Ser Gly Gly Gln Gln Gln Leu Ala Phe Asp Pro Gln Leu Gly 
        195                 200                 205             


Thr Ala Pro Glu Ile Ala Val Met Ser Thr Gly Glu Glu Ile Pro Tyr 
    210                 215                 220                 


Leu Gln Lys Glu Ala Ile Asn Phe Arg His Asp Ser Ala Gly Val Phe 
225                 230                 235                 240 


Met Pro Ser Thr Ser Pro Lys Pro Ser Thr Thr Asn Val Phe Thr Ser 
                245                 250                 255     


Ala Val Asp Gln Thr Ile Thr Pro Glu Leu Pro Glu Glu Lys Asp Lys 
            260                 265                 270         


Thr Asp Ser Leu Arg Glu Pro 
        275                 


<210>  11
<211>  273
<212>  PRT
<213>  Mus musculus

<400>  11

Met Lys Ile Ile Ile Leu Leu Gly Leu Ile Gly Ala Ser Ser Ser Ala 
1               5                   10                  15      


Pro Leu Ile Ser Gln Arg Leu Leu Ser Ala Ser Asn Ser His Glu Leu 
            20                  25                  30          


Leu Leu Asn Leu Asn Asn Gly Gln Leu Leu Pro Leu Gln Phe Gln Gly 
        35                  40                  45              


Ala Phe Asn Ser Trp Ile Pro Pro Phe Pro Gly Phe Leu Gln Gln Gln 
    50                  55                  60                  


Gln Ala Gln Val Ser Gly Arg Pro Gln Phe Thr Leu Ser Thr Leu Glu 
65                  70                  75                  80  


Ser Phe Ala Gly Leu Phe Pro Asn Gln Ile Pro Leu Ser Arg Gln Val 
                85                  90                  95      


Gly Leu Ala Gln Gly Gly Gln Ala Gly Gln Pro Asp Leu Ser Gln Gln 
            100                 105                 110         


Gln Thr Pro Pro Gln Thr Gln Gln Ser Ala Ser Pro Met Ser Tyr Val 
        115                 120                 125             


Val Pro Val Lys Val Pro Gln Asp Gln Thr Gln Met Phe Gln Tyr Tyr 
    130                 135                 140                 


Pro Val Tyr Met Leu Leu Pro Trp Glu Gln Pro Gln Thr Val Thr Ser 
145                 150                 155                 160 


Ser Pro Gln His Thr Gly Gln Gln Leu Phe Glu Glu Gln Ile Pro Phe 
                165                 170                 175     


Tyr Asn Gln Phe Gly Phe Ala Pro Pro Gln Ala Glu Pro Gly Val Pro 
            180                 185                 190         


Gly Gly Gln Gln His Leu Ala Phe Asp Ser Phe Val Gly Thr Ala Pro 
        195                 200                 205             


Glu Thr Pro Gly Met Pro Val Glu Gly Ser Leu Leu Tyr Pro Gln Lys 
    210                 215                 220                 


Glu Pro Ile Ser Phe Lys His Asp Asn Ala Gly Val Phe Met Pro Thr 
225                 230                 235                 240 


Thr Ser Pro Lys Pro Ser Thr Asp Asn Phe Phe Thr Ser Gly Ile Asp 
                245                 250                 255     


Pro Thr Ile Ala Pro Glu Gln Lys Val Lys Thr Asp Ser Leu Arg Glu 
            260                 265                 270         


Pro 
    


<210>  12
<211>  276
<212>  PRT
<213>  PIG

<400>  12

Met Arg Thr Leu Ile Leu Leu Gly Ile Leu Gly Ala Thr Met Ser Ala 
1               5                   10                  15      


Pro Leu Ile Pro Gln Arg Leu Met Ser Ala Ser Asn Ser Asn Glu Leu 
            20                  25                  30          


Leu Leu Asn Leu Asn Asn Ala Gln Leu Gln Pro Leu Gln Leu Gln Gly 
        35                  40                  45              


Pro Trp Ile Pro Pro Phe Pro Val Ile Leu Gln Gln Arg Gln Gln Gln 
    50                  55                  60                  


Ala Gln Ile Pro Gly Leu Ser Gln Phe Ser Leu Ala Asn Leu Asp Trp 
65                  70                  75                  80  


Phe Ala Gly Leu Val Pro Asn Gln Arg Ala Phe Pro Gly Gln Val Ser 
                85                  90                  95      


Phe Ala Gln Val Thr Glu Ala Arg Gln Leu Asp Pro Ser Gln Pro Gln 
            100                 105                 110         


Thr Ser Pro Gln Thr Gln Gln Gly Pro Asn Tyr Val Met Pro Ser Leu 
        115                 120                 125             


Leu Ser Phe Lys Met Pro Pro Glu Gln Gly Gln Met Leu Gln Tyr Tyr 
    130                 135                 140                 


Pro Val Tyr Met Leu Leu Pro Trp Glu Gln Ala Gln Gln Thr Ala Ala 
145                 150                 155                 160 


Gln Ser Pro Pro Gln Thr Gly Gln Gln Leu Phe Glu Glu Gln Met Pro 
                165                 170                 175     


Phe Tyr Thr Glu Leu Gly Tyr Val Pro Gln Gln Val Glu Pro Val Met 
            180                 185                 190         


Pro Gly Gly Gln Gln Gln Pro Val Phe Asp Pro Phe Leu Gly Thr Ala 
        195                 200                 205             


Pro Glu Thr Ala Val Met Thr Ala Glu Val Leu Pro Tyr Phe Gln Lys 
    210                 215                 220                 


Glu Met Ile Gln Phe Lys His Ser Asn Gly Gly Ile Phe Ile Pro Ser 
225                 230                 235                 240 


Thr Ser Gln Lys Pro Ser Thr Thr Asn Val Phe Thr Ser Thr Val Asp 
                245                 250                 255     


Pro Thr Ile Thr Pro Lys Val Met Glu Lys Lys Ala Lys Thr Asp Ser 
            260                 265                 270         


Leu Lys Glu Pro 
        275     


<210>  13
<211>  278
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Lys Ile Ile Ile Leu Leu Gly Leu Ile Gly Ala Thr Ser Ser Ala 
1               5                   10                  15      


Pro Leu Ile Thr Gln Arg Leu Leu Ser Ala Ser Asn Ser His Glu Leu 
            20                  25                  30          


Leu Leu Asn Leu Asn Asn Gly Gln Leu Leu Pro Leu Gln Phe Gln Ser 
        35                  40                  45              


Ala Phe Asn Ser Trp Ile Pro Pro Phe Pro Gly Leu Leu Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Ala Gln Val Ser Gly His Pro Gln Phe Pro Leu Ser Thr 
65                  70                  75                  80  


Leu Glu Ser Phe Ala Gly Leu Phe Pro Asn Gln Ile Pro Phe Ser Arg 
                85                  90                  95      


Gln Val Gly Phe Ala Gln Gly Gly Gln Ala Gly Gln Pro Asp Phe Ser 
            100                 105                 110         


Gln Gln Gln Thr Pro Ser Gln Thr Gln Gln Ala Ser Pro Met Ser Tyr 
        115                 120                 125             


Val Val Pro Val Glu Val Pro Gln Asp Gln Thr Gln Met Phe Gln Tyr 
    130                 135                 140                 


Tyr Pro Val Tyr Met Leu Leu Pro Trp Glu Gln Pro Gln Gln Thr Val 
145                 150                 155                 160 


Thr Ser Ser Pro Gln Gln Thr Gly Gln Gln Leu Tyr Glu Glu Gln Ile 
                165                 170                 175     


Pro Phe Tyr Asn Gln Phe Gly Phe Val Pro Gln Gln Ala Gly Pro Gly 
            180                 185                 190         


Val Pro Gly Gly Gln Gln His Leu Val Leu Asp Ser Phe Val Gly Thr 
        195                 200                 205             


Ala Pro Glu Thr Pro Gly Met Pro Ala Val Glu Gly Pro Leu Tyr Pro 
    210                 215                 220                 


Gln Lys Glu Pro Ile Gly Phe Lys Gln Asp Asn Val Gly Val Ser Thr 
225                 230                 235                 240 


Pro Ser Thr Ser Pro Lys Pro Asp Thr Gly Asn Phe Phe Thr Ser Glu 
                245                 250                 255     


Ile Asn Pro Thr Ile Ala Pro Leu Leu Pro Glu Gln Lys Val Asn Ala 
            260                 265                 270         


Asp Ser Leu Arg Glu Pro 
        275             


