                         SEQUENCE LISTING

<110>  Genzyme Corporation
 
<120>  PEGYLATED APELIN AND USES THEREOF

<130>  P-75918-PC

<140>  PCT/US12/999999
<141>  2012-03-05

<150>  61/451,623
<151>  2011-03-11

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Leu Arg Leu Cys Val Gln Ala Leu Leu Leu Leu Trp Leu Ser 
1               5                   10                  15      


Leu Thr Ala Val Cys Gly Gly Ser Leu Met Pro Leu Pro Asp Gly Asn 
            20                  25                  30          


Gly Leu Glu Asp Gly Asn Val Arg His Leu Val Gln Pro Arg Gly Ser 
        35                  40                  45              


Arg Asn Gly Pro Gly Pro Trp Gln Gly Gly Arg Arg Lys Phe Arg Arg 
    50                  55                  60                  


Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
65                  70                  75          


<210>  2
<211>  8271
<212>  DNA
<213>  Homo sapiens

<400>  2
agcggcgggg ctcagcgcgc acactcagcg gccggggagc ctcccgagct ctgcgcccgc       60

acgcgccagc cgcggctcgc gcctttcttg gcctccgggc gcccgacctc tcctcccccg      120

cgccggctcg ccggggccgc ggcggcccaa ggagcagcat gaatctgcgg ctctgcgtgc      180

aggcgctcct gctgctctgg ctctccttga ccgcggtgtg tggaggtgag tgcgcgccct      240

cccgctcgcc cgggctgcag ccggcgtgct cctttccctc cgccctattc gcactctccc      300

cgcctcccgg ggagcccggc gcgagccgtg cagtagcagc cacgcgccgg ccagcgccag      360

gcagcagatt gacagagcgc cccgagccat ggggcggctg gccacaagga ctgcttcttt      420

tgcggggctc aactcggcct ttggcatcac ctgcccgtca ccttgtccct cctaaccgtc      480

gctcgcagtc ccaggagctc aggaccacag gtgtgcgccg cgtgtcccac gccctgcacc      540

ccgcgtggta gaggtggagg cgggggacat gcccgctccc tcgtggatcg atggaaggaa      600

ctgaccagag tcgagtgggc tgggctccca tgttgaacgt cttctggtcc ctgaaggctg      660

ggagcctccc gccagtccag gggcgcggga aaccggggat gatgtgccaa catgcagacg      720

tgacacttgt tgcataggca ggagtgcgcg gagggggtgg cggcatggag cccagctgtt      780

gctcctttcg gcctgcatgt gtgagcagag gcagcctccc ccaggcaggg ccgggcccag      840

ccgggctggg ctggtcttct cctccctaac cccaaggtcc tggctggtct cctcccctgc      900

acaggatgcc ctccccatag cctccatccc acccccagag acttggttct cttacatcct      960

ggctccagcc ttcctttctg tcccaggcac ggacatgctt cactttagtc tccctgccgc     1020

taggcaccaa aggaggaagc acagcacctg acccgacccc tccctgcagc tcaggaaagg     1080

ggagtccttt tgccctcacc tgccaatact tggcactagt gcccatgtcc gcccctagcc     1140

tggtccccaa ccacgcccca gcagccccat cccaggctgc ctgtcctctg tgtcaatgtc     1200

tcctggggct gccagctccc acctccagct gccacagtcc tatgatctgg ctgtcattgc     1260

tgcctgcctg gcaccacaca aggggaaggc caagaccagg tggactaacg ccaggaccat     1320

ggctggagtc acagggaggt gggagcagaa agaaggagaa ggcagggcag tgagtttcct     1380

ggggcaaggg cacagggccc taagtggttc caaaccctcc agaacaggag gatggcatgc     1440

agcccaggag cctccgaggg gcccagccag ctctgcctgc ctctcatcgc aggccacctc     1500

ctttctctgc tcttgctttt tggccctgct gtggctctgg gaacactgcc tggcttctca     1560

gaaaggtgca gtggttgggg ctggcacctc ctgcctccag gtagctggcc ggtgatttct     1620

ctattcaaga cctgaacacg aagtgagcca ccaccacagt aagaagtggg taggcttttt     1680

ccacagaaac tcctgtcagg caggtaacag agggagcaaa agatacgaat gtaagatacg     1740

aatgatacac cataccagcc tatcctcagg gagcctacca tctggtgtca ttggcaaggc     1800

atgacacttg cacaatacca ccacaggcaa atagtccagg gtggtgcctt cagggaagaa     1860

gaagactggg tgcagagagt gttccagagg aaggtagggc tcctggatct gcacacttgg     1920

tgctcccccc agaggctgtg gggagacccc tggccaatag acaaccactc agaccctcct     1980

gggtcccagc cattgggaca gtactagcaa aggggagaga gctggtttca agggaaggga     2040

agtcagccag gatgcccgaa caccatgtgg ctggtccaga gcctgccact tcgtgcttta     2100

attcccccgt cttcattagg tcatctgtcc actgtgattt ggataaattc gttgccctca     2160

cattttgctc aagcctcgtg ctggaaactt tcagggctct cactgacttc tctactccct     2220

gacttctcct ggagccaagg aagggcatgt ccctggaagt ggccaccagc caagggtcca     2280

ggtacacatg tcctgctccc gctggctcct gtcctgggtt agaagcagga atcccagaac     2340

cactttgtcc ttggcccgga ctggcatgct gtccccagcc agagtcccca gtcaaagttc     2400

cagcctgaaa accacacttc ctcctctcca cagtctgtcc tgacttgaaa tgtccacccc     2460

cgacccctct ccacgctgcc tctcatcacc ccgctaccac cacgtacact cctccactgc     2520

ctcctgacct gggatacact ttgctcttgt gagtctgaga actcctggtc cagggccaag     2580

tgtccctcgg tctctgagca cccctctttt tccccttctc ctccccctcc gcaggcccag     2640

ctcaaagcct gcagtcacag tgggagtgtg aggagagcct actgtacccc tcctgctcag     2700

ggaagggcat ctctactcca tccccagtcc tcagcactaa gcacccgtgt aacctgagcc     2760

aggcctctcc tcgcaaagaa ctaaggcaag ggaagcagag ggccaccaga cagagcatga     2820

tgtatcccag ggcagcaaag ctggcactgg agacagcaca gggccctgga gaaggcgact     2880

gggatggggg gctgggcaga caaagagaca catgcaggac cacagagcag tggaggggca     2940

ttgccagcag ggtccccacc ggagcatacg tttgggcttt taaagtcatc acaagacagg     3000

ccagactgag agaggaaaaa caggtgcgtc attcctgatg agactggcat gttcctgaaa     3060

agtcgcaagt acctctttgt gcattggcag ggttggagtt cagatagcat gaaagtcaaa     3120

tcctgtcctc cccctgactg tggttctcag cgtggagatg ttgtagcttc gtggctgatg     3180

gcacttcagc aggcaatggc tccaatctct ctaggctcga gattgtttgg aggattgctc     3240

cagcctcctt ttacgtagca aatgagctgg aagaaaatat ttaagtgcat tagggctggc     3300

ctccatttct aaaggggaat tcttttttac agtcaagact tctgcagtga tgagaatcaa     3360

cagcctctaa tttgttcctt tggacagcat aaagccaggg tttcagatgt cagcttatct     3420

gatggtgagc cagactcaga atcaaaagta ggaaacaggt gggtgacggg ctcagagtgc     3480

gggaggagcc agcagatctc ggtgatgctg aggacaatga gtccccaacg caatgggagg     3540

gatgcaagaa gcctggggct gctctccagg gcccggctgg gggttcagtc agctcagagt     3600

ggttcttctc tgcagaccta gagtctagac atcttcctgg ccagagccac caaccctgct     3660

ccccatcctg acatatggcc tctagccctc cctttctgac tgccagacac tcacaatctg     3720

agcacctgga gatgatgccc tccccctcct ggcaccatgc ttctcttctc catgtctgcc     3780

accaccctga gctacaatgg cctgcaccac tgccccatcc cttctgcacc cccagcagtc     3840

gaaggtgcag aggtgagagc caagtgttga cttggttcac ttcacaaggc ccctaggtcc     3900

ttcccctgct ccttatcagc atcattcaga tccgccctca gtgatcaggg tgagccttgt     3960

ggggacccca gaactcaagg cagaggctga agcagctgca gtggggagct tagtgaaggt     4020

ctttccttcc tttccctctc cagccccagc cccctcacag atggcgccaa gagggtagct     4080

ctatgacagt cagacagaag cagccccctt gttccatcca tacttactgc tccaaagtgc     4140

taagataatt cttcttttaa ttctcatagg ttatgaattt aagggataag ttggcacgga     4200

agtgtggcta gttaaccaaa tgacccaagt caacagcggg gtcctcatgg gcctggcaat     4260

ttttcttggg gaaagaggga aggagggtgc aggcttggag aatatgtgtt tatgtgtgtg     4320

tgtgtggagg gggtgggtat gtctgggtgt gagtggggag aactgcaggc tcagaagcct     4380

gggggaagag ggccctaagg ccaaacccac ccacttttgg cccaagagga ggctgaacac     4440

ttggaaattg tgtgcaagca gaggaggact cacaaaaacc aaggagccaa ggaaggaaca     4500

gagcgtgggg atgttggagg cagaggcaga ggggaagggg gagctgccag gggtatgatt     4560

ggggtgtgag cagccaatgg gaggctctat ggaaactgtg agcaagtggt gggaattcct     4620

gggtagatgg caatggggct cgagggacag ggatctagat gcaggcaaat cagatggtgt     4680

gcagggggag agagactgtt attcattatc tctggcctca gatgctgtat ctgcacaggc     4740

ctgtactgga cattgcacaa gtaccctgcc tggctgcctc ttccccagca ccatctcatc     4800

tccacacact gcctgccacc accagccagg cttgtcttgg gggtggcagc tcagcttccc     4860

tgcatggact gcaggcttca cgagagtcgg cctgcatgcc ttttccctca ctgcacccaa     4920

ggataccctg caccacttgg attccattgt cagggctcag tctggtgtca ggaggcctct     4980

actctaagcc tcctgacaga tgtggacaga tgtaaagagg agccccagag tgcagaatag     5040

aagccagctg ggattgaaat ggaaggaatt tacatgagac acaggatgca gggtgtgatc     5100

tgggaatttc aggaggtagg gcattggtgg ggaggtacca actgcaacag cccacccccc     5160

tcctggtgca cagacatgct gctgaaggtg accattgttt catttattca ttctcaaata     5220

ttcatgcaat atttattggt ctctaaatct ggtctcaggt ctctaaatct ggtcacagca     5280

tgaggcaggc tgagtcagag acctctcccc cttaacccgc ctggcccagc cccatccact     5340

gggaggactt ggcgccctag agatgcctaa ccaccgatga gacacccagg ggcgagatat     5400

gagctcccta gtactcacaa gtgggtcatc ctgcatatca aaggatgtag gagtacaatg     5460

acgtgatgtt cgggatttgc tttaaaatac tgcagtcaag gaaaatagaa aagggataac     5520

taaagcatat gtgactccat ctggataact gttgaatctg ggtgatgggt ccatggcggt     5580

gggagggtca ttgtaatgtc atatgtctga aatgtttgaa gtgtaccagt tgcaggggtg     5640

ccgtggtgat tactgcctcc tgccccccag ccaagtacag gcgtgacaac ccaaagtgca     5700

caccccccaa tgacgttcca aagaaagaac ccacttgtgc ctgtcagaaa catgatataa     5760

ctgtcaaaag gacagaaagt cagctacatc aatggcaaga tgtgagtagt aggttccgtt     5820

tgtcccagga cagtgcagaa atggcaaatt ttccctcaat atgaaaaaaa gaaacaaaga     5880

aaatctatga gaagtgccac cacatggaca gaccacccct cccgcgggcc tgtggtctgc     5940

agcccctgcc cgtttccaac aaccttcctc actaacaggc tttctccttc ctgcagggtc     6000

cctgatgccg cttcccgatg ggaatgggct ggaagacggc aatgtccgcc acctggtgca     6060

gcccagaggg tcaaggaatg ggccagggcc ctggcaggga ggtcggagga aattccgccg     6120

ccagcggccc cgcctctccc ataagggacc catgcctttc tgaagcaggt acttgagcct     6180

ctgttcagtg gacagtgcta aagcggaggg agaaggacag cctagaagcc gggtgatcct     6240

gccgctcatc actggccaga cacatccatc aaacagtcct ggcgccacac tcacagaggc     6300

ttagagctgg caagagagct tatggggcag ctgtctagcc cctttatttt acagacgatc     6360

tcctcgtctg aggcctagag aggggcttga tacttggggc cagtctccct tccaccctgc     6420

tgcctggggt tggggaggct ggcctgctta gagatttcta gacatcctgg tggaccttaa     6480

tggctgggga ggggtgccca gggcaaacct acagatgtcc agtgtagatt gtcgccagag     6540

ttggggaagg aggcagagag ctctaggggc tctcaggcag agaacaagag gacagttgtg     6600

gctgtggttg cccggagctg tgagaaggag ggaagaacca aggtggcagc agagagagga     6660

gagctgaagc ctgccccttc cctggtctgc tggctgtccc actgcagtgg ggacaggcag     6720

gcaccaactc aggggccttg ggattgaggt ttgggctgag tggagtttgg gggaaagaga     6780

aggcggtctc ctctctcctc tcctttcctg gggagttcct ttggcctagg atatgtccat     6840

gacttctctc ttgtcatttt tgtctcctta ggactgaagg ggcccccaag tgcccacccc     6900

cggcggttat gtctcctcca tagattggtc tgcttctctg gaggcctcac gtccattcag     6960

ctctcacctc gcacctgctg tagccaccag tgggcccagc tcttctcacc tgcctgcttc     7020

ccccagtggc gtgctcctgg ctgtagtttg gatgattccc gttctctcac aagaatccgt     7080

ccagtccatc ttcctggccc ctccctggac tgactttgga gacctagccc cagaaagcct     7140

cccttcttct ccaggtcccc tccgccctag tccctgcctg tctcatctaa cgccccaaac     7200

cttcatttgg gccttccttc ctcatgtctg ccctgagcgc ggggtggaag tgctcccttc     7260

tgtgggctcc agcagatccc ttgttttcct gtcagttgga cccctcacct ggcctccagg     7320

gaagaatgca gagaaaagca aggagagact ctagttaaga ggtgctggct gcggggatcc     7380

agacagggca cattgggggc atggaagtgc cagggtggtt ttcaggagct ctggtgaagt     7440

gggtggagca tcagcgtttg ctcagttaag ggagaggtag agaggggccc gtgaagtcct     7500

ttgtcacttc tcttgcctta gtgtgcctcc caatactccc ttcttcctgc ccccacaccc     7560

catccccagc tagcccaagc tccaggtcag gaggggaggg tgctgggcct gacatggcta     7620

tataccctcc caggagtaaa agccaagcaa gaggttgttt ttgccaagaa tcacagaatg     7680

ttagagctga caggaccctt gaaggtcact tagccttctt aggcaaacgc ctgcaaaaca     7740

gaagcctgga gaggggagtg acctgctcag agtcattgca gagccgggat ggggaccagg     7800

tctcccatct cctactttat gacgccctct tccctcttga tgatgtcttt tcaaagcaaa     7860

tgaagtgcct tttcccgagg ctggggctgg gggtggctgg gaggggaagg gaagggagag     7920

gcaagctggc tgtgaactgt cctgttgtgg ggctggagct gctcccacct ccctgaccta     7980

cccctgctgc accattcccc cagctgggct ggaaggttcc ataactggcc agctgccccc     8040

ataactggca gcattcccag acccagggta ctctaatagg ggcggctcag gcactgagac     8100

taccgctcaa ccccagggtg gttttcagga gtccgaggta gccttcaatc actggactcc     8160

atggccttcc cttcgtgttg accggacctt ccttccaggg cttttccttt gggggaggcg     8220

gagaggggag aagaaggaag ggaagggcag aaggaaggag ggaagaaaag a              8271


