                         SEQUENCE LISTING

<110>  Amgen Inc.
       Liu, Zhi
       Kannan, Gunasekaran
       Yan, Wei
 
<120>  Fc VARIANTS

<130>  A-1618-WO-PCT

<140>  --to be assigned--
<141>  2012-03-15

<150>  61/453,433
<151>  2011-03-16

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<400>  1
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  2
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  3
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (529)..(529)

<220>
<221>  mutation
<222>  (531)..(531)

<220>
<221>  mutation
<222>  (580)..(580)

<220>
<221>  mutation
<222>  (582)..(582)

<400>  3
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

gac acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc gac ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  4
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  5
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (421)..(421)

<220>
<221>  mutation
<222>  (550)..(550)

<220>
<221>  mutation
<222>  (552)..(552)

<400>  5
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg aag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

aag acc acg cct ccc gtg ctg aag tcc gac ggc tcc ttc ttc ctc tat        576
Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  6
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  7
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (286)..(286)

<220>
<221>  mutation
<222>  (287)..(287)

<220>
<221>  mutation
<222>  (355)..(355)

<220>
<221>  mutation
<222>  (356)..(356)

<220>
<221>  mutation
<222>  (357)..(357)

<220>
<221>  mutation
<222>  (529)..(529)

<220>
<221>  mutation
<222>  (531)..(531)

<220>
<221>  mutation
<222>  (580)..(580)

<220>
<221>  mutation
<222>  (582)..(582)

<400>  7
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac atg        288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Met           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca gcc ccc atc gag gtg acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Ala Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

gac acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc gac ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  8
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Met 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  9
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (55)..(55)

<220>
<221>  mutation
<222>  (56)..(56)

<220>
<221>  mutation
<222>  (57)..(57)

<220>
<221>  mutation
<222>  (235)..(235)

<220>
<221>  mutation
<222>  (236)..(236)

<220>
<221>  mutation
<222>  (242)..(242)

<220>
<221>  mutation
<222>  (243)..(243)

<220>
<221>  mutation
<222>  (421)..(421)

<220>
<221>  mutation
<222>  (550)..(550)

<220>
<221>  mutation
<222>  (552)..(552)

<400>  9
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa tat ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Tyr Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag ctg cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Leu Gln           
65                  70                  75                  80            

tgg aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Trp Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg aag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

aag acc acg cct ccc gtg ctg aag tcc gac ggc tcc ttc ttc ctc tat        576
Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  10
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Tyr Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Leu Gln 
65                  70                  75                  80  


Trp Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  11
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (52)..(52)

<220>
<221>  mutation
<222>  (53)..(53)

<220>
<221>  mutation
<222>  (54)..(54)

<220>
<221>  mutation
<222>  (286)..(286)

<220>
<221>  mutation
<222>  (287)..(287)

<220>
<221>  mutation
<222>  (355)..(355)

<220>
<221>  mutation
<222>  (356)..(356)

<220>
<221>  mutation
<222>  (357)..(357)

<220>
<221>  mutation
<222>  (529)..(529)

<220>
<221>  mutation
<222>  (531)..(531)

<220>
<221>  mutation
<222>  (580)..(580)

<220>
<221>  mutation
<222>  (582)..(582)

<400>  11
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct ctg ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Leu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac atg        288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Met           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca gcc ccc atc gag gtg acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Ala Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

gac acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc gac ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  12
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Leu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Met 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  13
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (55)..(55)

<220>
<221>  mutation
<222>  (286)..(286)

<220>
<221>  mutation
<222>  (287)..(287)

<220>
<221>  mutation
<222>  (355)..(355)

<220>
<221>  mutation
<222>  (356)..(356)

<220>
<221>  mutation
<222>  (357)..(357)

<220>
<221>  mutation
<222>  (529)..(529)

<220>
<221>  mutation
<222>  (531)..(531)

<220>
<221>  mutation
<222>  (580)..(580)

<220>
<221>  mutation
<222>  (582)..(582)

<400>  13
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa atc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Ile Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac atg        288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Met           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca gcc ccc atc gag gtg acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Ala Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

gac acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc gac ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  14
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ile Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Met 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  15
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (248)..(248)

<220>
<221>  mutation
<222>  (355)..(355)

<220>
<221>  mutation
<222>  (356)..(356)

<220>
<221>  mutation
<222>  (357)..(357)

<220>
<221>  mutation
<222>  (529)..(529)

<220>
<221>  mutation
<222>  (531)..(531)

<220>
<221>  mutation
<222>  (580)..(580)

<220>
<221>  mutation
<222>  (582)..(582)

<400>  15
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac acc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Tyr Asn Thr Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca gcc ccc atc gag gtg acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Ala Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

gac acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc gac ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  16
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Thr Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  17
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (55)..(55)

<220>
<221>  mutation
<222>  (56)..(56)

<220>
<221>  mutation
<222>  (57)..(57)

<220>
<221>  mutation
<222>  (223)..(223)

<220>
<221>  mutation
<222>  (225)..(225)

<220>
<221>  mutation
<222>  (242)..(242)

<220>
<221>  mutation
<222>  (243)..(243)

<220>
<221>  mutation
<222>  (421)..(421)

<220>
<221>  mutation
<222>  (550)..(550)

<220>
<221>  mutation
<222>  (552)..(552)

<400>  17
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa tat ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Tyr Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca tat ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Tyr Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tgg aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Trp Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg aag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

aag acc acg cct ccc gtg ctg aag tcc gac ggc tcc ttc ttc ctc tat        576
Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  18
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Tyr Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Tyr Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Trp Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  19
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (343)..(343)

<220>
<221>  mutation
<222>  (344)..(344)

<220>
<221>  mutation
<222>  (345)..(345)

<220>
<221>  mutation
<222>  (355)..(355)

<220>
<221>  mutation
<222>  (356)..(356)

<220>
<221>  mutation
<222>  (357)..(357)

<220>
<221>  mutation
<222>  (529)..(529)

<220>
<221>  mutation
<222>  (531)..(531)

<220>
<221>  mutation
<222>  (580)..(580)

<220>
<221>  mutation
<222>  (582)..(582)

<400>  19
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca atg ccc atc gag gtg acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Met Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

gac acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc gac ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  20
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Met Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  21
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (343)..(343)

<220>
<221>  mutation
<222>  (344)..(344)

<220>
<221>  mutation
<222>  (355)..(355)

<220>
<221>  mutation
<222>  (356)..(356)

<220>
<221>  mutation
<222>  (357)..(357)

<220>
<221>  mutation
<222>  (529)..(529)

<220>
<221>  mutation
<222>  (531)..(531)

<220>
<221>  mutation
<222>  (580)..(580)

<220>
<221>  mutation
<222>  (582)..(582)

<400>  21
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca ttc ccc atc gag gtg acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Phe Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

gac acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc gac ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  22
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Phe Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  23
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (286)..(286)

<220>
<221>  mutation
<222>  (287)..(287)

<220>
<221>  mutation
<222>  (343)..(343)

<220>
<221>  mutation
<222>  (344)..(344)

<220>
<221>  mutation
<222>  (345)..(345)

<220>
<221>  mutation
<222>  (355)..(355)

<220>
<221>  mutation
<222>  (356)..(356)

<220>
<221>  mutation
<222>  (357)..(357)

<220>
<221>  mutation
<222>  (529)..(529)

<220>
<221>  mutation
<222>  (531)..(531)

<220>
<221>  mutation
<222>  (580)..(580)

<220>
<221>  mutation
<222>  (582)..(582)

<400>  23
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac atg        288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Met           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca atg ccc atc gag gtg acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Met Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

gac acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc gac ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  24
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  24

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Met 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Met Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  25
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (286)..(286)

<220>
<221>  mutation
<222>  (287)..(287)

<220>
<221>  mutation
<222>  (343)..(343)

<220>
<221>  mutation
<222>  (344)..(344)

<220>
<221>  mutation
<222>  (355)..(355)

<220>
<221>  mutation
<222>  (356)..(356)

<220>
<221>  mutation
<222>  (357)..(357)

<220>
<221>  mutation
<222>  (529)..(529)

<220>
<221>  mutation
<222>  (531)..(531)

<220>
<221>  mutation
<222>  (580)..(580)

<220>
<221>  mutation
<222>  (582)..(582)

<400>  25
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac atg        288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Met           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca ttc ccc atc gag gtg acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Phe Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

gac acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc gac ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  26
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Met 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Phe Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  27
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (248)..(248)

<220>
<221>  mutation
<222>  (343)..(343)

<220>
<221>  mutation
<222>  (344)..(344)

<220>
<221>  mutation
<222>  (345)..(345)

<220>
<221>  mutation
<222>  (355)..(355)

<220>
<221>  mutation
<222>  (356)..(356)

<220>
<221>  mutation
<222>  (357)..(357)

<220>
<221>  mutation
<222>  (529)..(529)

<220>
<221>  mutation
<222>  (531)..(531)

<220>
<221>  mutation
<222>  (580)..(580)

<220>
<221>  mutation
<222>  (582)..(582)

<400>  27
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac acc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Tyr Asn Thr Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca atg ccc atc gag gtg acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Met Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

gac acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc gac ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  28
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Thr Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Met Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  29
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (248)..(248)

<220>
<221>  mutation
<222>  (343)..(343)

<220>
<221>  mutation
<222>  (344)..(344)

<220>
<221>  mutation
<222>  (355)..(355)

<220>
<221>  mutation
<222>  (356)..(356)

<220>
<221>  mutation
<222>  (357)..(357)

<220>
<221>  mutation
<222>  (529)..(529)

<220>
<221>  mutation
<222>  (531)..(531)

<220>
<221>  mutation
<222>  (580)..(580)

<220>
<221>  mutation
<222>  (582)..(582)

<400>  29
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac acc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Tyr Asn Thr Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca ttc ccc atc gag gtg acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Phe Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

gac acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc gac ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  30
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Thr Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Phe Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  31
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (70)..(70)

<220>
<221>  mutation
<222>  (71)..(71)

<220>
<221>  mutation
<222>  (72)..(72)

<220>
<221>  mutation
<222>  (343)..(343)

<220>
<221>  mutation
<222>  (344)..(344)

<220>
<221>  mutation
<222>  (345)..(345)

<220>
<221>  mutation
<222>  (355)..(355)

<220>
<221>  mutation
<222>  (356)..(356)

<220>
<221>  mutation
<222>  (357)..(357)

<220>
<221>  mutation
<222>  (529)..(529)

<220>
<221>  mutation
<222>  (531)..(531)

<220>
<221>  mutation
<222>  (580)..(580)

<220>
<221>  mutation
<222>  (582)..(582)

<400>  31
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg gac gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca atg ccc atc gag gtg acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Met Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

gac acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc gac ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  32
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Met Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  33
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (70)..(70)

<220>
<221>  mutation
<222>  (71)..(71)

<220>
<221>  mutation
<222>  (72)..(72)

<220>
<221>  mutation
<222>  (248)..(248)

<220>
<221>  mutation
<222>  (355)..(355)

<220>
<221>  mutation
<222>  (356)..(356)

<220>
<221>  mutation
<222>  (357)..(357)

<220>
<221>  mutation
<222>  (529)..(529)

<220>
<221>  mutation
<222>  (531)..(531)

<220>
<221>  mutation
<222>  (580)..(580)

<220>
<221>  mutation
<222>  (582)..(582)

<400>  33
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg gac gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac acc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Tyr Asn Thr Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca gcc ccc atc gag gtg acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Ala Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

gac acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc gac ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  34
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Thr Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  35
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  35

Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp 
1               5                   10                  15      


Tyr Ser Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala 
            20                  25                  30          


Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu 
        35                  40                  45              


Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asn 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro 
                85                  90                  95      


Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser 
            100                 105                 110         


Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys 
        115                 120                 125             


Asp Arg Lys Tyr Phe His His Asn Ser Asp Phe His Ile Pro Lys Ala 
    130                 135                 140                 


Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly Ser 
145                 150                 155                 160 


Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu 
                165                 170                 175     


<210>  36
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (343)..(343)

<220>
<221>  mutation
<222>  (344)..(344)

<220>
<221>  mutation
<222>  (345)..(345)

<220>
<221>  mutation
<222>  (355)..(355)

<220>
<221>  mutation
<222>  (356)..(356)

<220>
<221>  mutation
<222>  (357)..(357)

<220>
<221>  mutation
<222>  (529)..(529)

<220>
<221>  mutation
<222>  (531)..(531)

<220>
<221>  mutation
<222>  (580)..(580)

<220>
<221>  mutation
<222>  (582)..(582)

<400>  36
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca atg ccc atc gag gtg acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Met Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

gac acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat        576
Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc gac ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  37
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  37

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Met Pro Ile Glu Val Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  38
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (55)..(55)

<220>
<221>  mutation
<222>  (56)..(56)

<220>
<221>  mutation
<222>  (57)..(57)

<220>
<221>  mutation
<222>  (242)..(242)

<220>
<221>  mutation
<222>  (243)..(243)

<220>
<221>  mutation
<222>  (421)..(421)

<220>
<221>  mutation
<222>  (550)..(550)

<220>
<221>  mutation
<222>  (552)..(552)

<400>  38
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa tat ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Tyr Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tgg aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Trp Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg aag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

aag acc acg cct ccc gtg ctg aag tcc gac ggc tcc ttc ttc ctc tat        576
Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  39
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Tyr Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Trp Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  40
<211>  699
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(699)

<220>
<221>  mutation
<222>  (223)..(223)

<220>
<221>  mutation
<222>  (225)..(225)

<220>
<221>  mutation
<222>  (242)..(242)

<220>
<221>  mutation
<222>  (243)..(243)

<220>
<221>  mutation
<222>  (421)..(421)

<220>
<221>  mutation
<222>  (550)..(550)

<220>
<221>  mutation
<222>  (552)..(552)

<400>  40
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca         48
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala           
1               5                   10                  15                

cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc         96
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro           
            20                  25                  30                    

aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg        144
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val           
        35                  40                  45                        

gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg        192
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val           
    50                  55                  60                            

gac ggc gtg gag gtg cat aat gcc aag aca tat ccg cgg gag gag cag        240
Asp Gly Val Glu Val His Asn Ala Lys Thr Tyr Pro Arg Glu Glu Gln           
65                  70                  75                  80            

tgg aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag        288
Trp Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln           
                85                  90                  95                

gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc        336
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala           
            100                 105                 110                   

ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc        384
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro           
        115                 120                 125                       

cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg aag gag atg acc        432
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr           
    130                 135                 140                           

aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc        480
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser           
145                 150                 155                 160           

gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac        528
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr           
                165                 170                 175               

aag acc acg cct ccc gtg ctg aag tcc gac ggc tcc ttc ttc ctc tat        576
Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr           
            180                 185                 190                   

agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc        624
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe           
        195                 200                 205                       

tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag        672
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys           
    210                 215                 220                           

agc ctc tcc ctg tct ccg ggt aaa tga                                    699
Ser Leu Ser Leu Ser Pro Gly Lys                                           
225                 230                                                   


<210>  41
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Tyr Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Trp Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


