                         SEQUENCE LISTING

<110>  UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
       KACHLANY, Scott  Charles
 
<120>  Combination Therapy With Leukotoxin

<130>  096738.00216

<150>  61/453,162
<151>  2011-03-16

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  1055
<212>  PRT
<213>  Aggregatibacter actinomycetemcomitans

<400>  1

Met Ala Thr Thr Ser Leu Leu Asn Thr Lys Gln Gln Ala Ala Gln Phe 
1               5                   10                  15      


Ala Asn Ser Val Ala Asp Arg Ala Lys Glu Asn Ile Asp Ala Ala Lys 
            20                  25                  30          


Glu Gln Leu Gln Lys Ala Leu Asp Lys Leu Gly Lys Thr Gly Lys Lys 
        35                  40                  45              


Leu Thr Leu Tyr Ile Lys Asn Tyr Lys Lys Gly Asn Gly Leu Thr Ala 
    50                  55                  60                  


Leu Ile Lys Ala Ala Gln Lys Leu Gly Ile Glu Val Tyr His Glu Gly 
65                  70                  75                  80  


Lys Asp Gly Pro Ala Leu Thr Asn Gly Ile Leu Asn Thr Gly Lys Lys 
                85                  90                  95      


Leu Leu Gly Leu Thr Glu Arg Gly Leu Thr Leu Phe Ala Pro Glu Leu 
            100                 105                 110         


Asp Lys Trp Ile Gln Gly Asn Lys His Leu Ser Asn Ser Val Gly Ser 
        115                 120                 125             


Thr Gly Asn Leu Thr Lys Ala Ile Asp Lys Val Gln Ser Val Leu Gly 
    130                 135                 140                 


Thr Leu Gln Ala Phe Leu Asn Thr Ala Phe Ser Gly Met Asp Leu Asp 
145                 150                 155                 160 


Ala Leu Ile Lys Ala Arg Gln Asn Gly Lys Asn Val Thr Asp Val Gln 
                165                 170                 175     


Leu Ala Lys Ala Ser Leu Asn Leu Ile Asn Glu Leu Ile Gly Thr Ile 
            180                 185                 190         


Ser Ser Ile Thr Asn Asn Val Asp Thr Phe Ser Lys Gln Leu Asn Lys 
        195                 200                 205             


Leu Gly Glu Ala Leu Gly Gln Val Lys His Phe Gly Ser Phe Gly Asp 
    210                 215                 220                 


Lys Leu Lys Asn Leu Pro Lys Leu Gly Asn Leu Gly Lys Gly Leu Gly 
225                 230                 235                 240 


Ala Leu Ser Gly Val Leu Ser Ala Ile Ser Ala Ala Leu Leu Leu Ala 
                245                 250                 255     


Asn Lys Asp Ala Asp Thr Ala Thr Lys Ala Ala Ala Ala Ala Glu Leu 
            260                 265                 270         


Thr Asn Lys Val Leu Gly Asn Ile Gly Lys Ala Ile Thr Gln Tyr Leu 
        275                 280                 285             


Ile Ala Gln Arg Ala Ala Ala Gly Leu Ser Thr Thr Gly Pro Val Ala 
    290                 295                 300                 


Gly Leu Ile Ala Ser Val Val Ser Leu Ala Ile Ser Pro Leu Ser Phe 
305                 310                 315                 320 


Leu Gly Ile Ala Lys Gln Phe Asp Arg Ala Arg Met Leu Glu Glu Tyr 
                325                 330                 335     


Ser Lys Arg Phe Lys Lys Phe Gly Tyr Asn Gly Asp Ser Leu Leu Gly 
            340                 345                 350         


Gln Phe Tyr Lys Asn Thr Gly Ile Ala Asp Ala Ala Ile Thr Thr Ile 
        355                 360                 365             


Asn Thr Val Leu Ser Ala Ile Ala Ala Gly Val Gly Ala Ala Ser Ala 
    370                 375                 380                 


Gly Ser Leu Val Gly Ala Pro Ile Gly Leu Leu Val Ser Ala Ile Thr 
385                 390                 395                 400 


Ser Leu Ile Ser Gly Ile Leu Asp Ala Ser Lys Gln Ala Val Phe Glu 
                405                 410                 415     


His Ile Ala Asn Gln Leu Ala Asp Lys Ile Lys Ala Trp Glu Asn Lys 
            420                 425                 430         


Tyr Gly Lys Asn Tyr Phe Glu Asn Gly Tyr Asp Ala Arg His Ser Ala 
        435                 440                 445             


Phe Leu Glu Asp Ser Leu Lys Leu Phe Asn Glu Leu Arg Glu Lys Tyr 
    450                 455                 460                 


Lys Thr Glu Asn Ile Leu Ser Ile Thr Gln Gln Gly Trp Asp Gln Arg 
465                 470                 475                 480 


Ile Gly Glu Leu Ala Gly Ile Thr Arg Asn Gly Asp Arg Ile Gln Ser 
                485                 490                 495     


Gly Lys Ala Tyr Val Asp Tyr Leu Lys Lys Gly Glu Glu Leu Ala Lys 
            500                 505                 510         


His Ser Asp Lys Phe Thr Lys Gln Ile Leu Asp Pro Ile Lys Gly Asn 
        515                 520                 525             


Ile Asp Leu Ser Gly Ile Lys Gly Ser Thr Thr Leu Thr Phe Leu Asn 
    530                 535                 540                 


Pro Leu Leu Thr Ala Gly Lys Glu Glu Arg Lys Thr Arg Gln Ser Gly 
545                 550                 555                 560 


Lys Tyr Glu Phe Ile Thr Glu Leu Lys Val Lys Gly Arg Thr Asp Trp 
                565                 570                 575     


Lys Val Lys Gly Val Pro Asn Ser Asn Gly Val Tyr Asp Phe Ser Asn 
            580                 585                 590         


Leu Ile Gln His Ala Val Thr Arg Asp Asn Lys Val Leu Glu Ala Arg 
        595                 600                 605             


Leu Ile Ala Asn Leu Gly Ala Lys Asp Asp Tyr Val Phe Val Gly Ser 
    610                 615                 620                 


Gly Ser Thr Ile Val Asn Ala Gly Asp Gly Tyr Asp Val Val Asp Tyr 
625                 630                 635                 640 


Ser Lys Gly Arg Thr Gly Ala Leu Thr Ile Asp Gly Arg Asn Ala Thr 
                645                 650                 655     


Lys Ala Gly Gln Tyr Lys Val Glu Arg Asp Leu Ser Gly Thr Gln Val 
            660                 665                 670         


Leu Gln Glu Thr Val Ser Lys Gln Glu Thr Lys Arg Gly Lys Val Thr 
        675                 680                 685             


Asp Leu Leu Glu Tyr Arg Asn Tyr Lys Leu Asp Tyr Tyr Tyr Thr Asn 
    690                 695                 700                 


Lys Gly Phe Lys Ala His Asp Glu Leu Asn Ser Val Glu Glu Ile Ile 
705                 710                 715                 720 


Gly Ser Thr Leu Arg Asp Lys Phe Tyr Gly Ser Lys Phe Asn Asp Val 
                725                 730                 735     


Phe His Gly His Asp Gly Asp Asp Leu Ile Tyr Gly Tyr Asp Gly Asp 
            740                 745                 750         


Asp Arg Leu Tyr Gly Asp Asn Gly Asn Asp Glu Ile His Gly Gly Gln 
        755                 760                 765             


Gly Asn Asp Lys Leu Tyr Gly Gly Ala Gly Asn Asp Arg Leu Phe Gly 
    770                 775                 780                 


Glu Tyr Gly Asn Asn Tyr Leu Asp Gly Gly Glu Gly Asp Asp His Leu 
785                 790                 795                 800 


Glu Gly Gly Asn Gly Ser Asp Ile Leu Arg Gly Gly Ser Gly Asn Asp 
                805                 810                 815     


Lys Leu Phe Gly Asn Gln Gly Asp Asp Leu Leu Asp Gly Gly Glu Gly 
            820                 825                 830         


Asp Asp Gln Leu Ala Gly Gly Glu Gly Asn Asp Ile Tyr Val Tyr Arg 
        835                 840                 845             


Lys Glu Tyr Gly His His Thr Ile Thr Glu His Ser Gly Asp Lys Asp 
    850                 855                 860                 


Lys Leu Ser Leu Ala Asn Ile Asn Leu Lys Asp Val Ser Phe Glu Arg 
865                 870                 875                 880 


Asn Gly Asn Asp Leu Leu Leu Lys Thr Asn Asn Arg Thr Ala Val Thr 
                885                 890                 895     


Phe Lys Gly Trp Phe Ser Lys Pro Asn Ser Ser Ala Gly Leu Asp Glu 
            900                 905                 910         


Tyr Gln Arg Lys Leu Leu Glu Tyr Ala Pro Glu Lys Asp Arg Ala Arg 
        915                 920                 925             


Leu Lys Arg Gln Phe Glu Leu Gln Arg Gly Lys Val Asp Lys Ser Leu 
    930                 935                 940                 


Asn Asn Lys Val Glu Glu Ile Ile Gly Lys Asp Gly Glu Arg Ile Thr 
945                 950                 955                 960 


Ser Gln Asp Ile Asp Asn Leu Phe Asp Lys Ser Gly Asn Lys Lys Thr 
                965                 970                 975     


Ile Ser Pro Gln Glu Leu Ala Gly Leu Ile Lys Asn Lys Gly Lys Ser 
            980                 985                 990         


Ser Ser Leu Met Ser Ser Ser Arg  Ser Ser Ser Met Leu  Thr Gln Lys 
        995                 1000                 1005             


Ser Gly  Leu Ser Asn Asp Ile  Ser Arg Ile Ile Ser  Ala Thr Ser 
    1010                 1015                 1020             


Gly Phe  Gly Ser Ser Gly Lys  Ala Leu Ser Ala Ser  Pro Leu Gln 
    1025                 1030                 1035             


Thr Asn  Asn Asn Phe Asn Ser  Tyr Ala Asn Ser Leu  Ala Thr Thr 
    1040                 1045                 1050             


Ala Ala  
    1055 


<210>  2
<211>  3168
<212>  DNA
<213>  Aggregatibacter actinomycetemcomitans

<400>  2
atggcaacta cttcactgct aaatacaaaa cagcaagctg cacagtttgc aaattcagtt       60

gcagatagag ctaaggaaaa tattgatgct gcaaaagaac aattgcaaaa ggcgttagat      120

aaattaggga agacaggtaa gaaattaact ttatatatcc ctaagaatta caaaaaagga      180

aatggtctta ctgcgcttat aaaagcagca cagaagttag ggattgaagt atatcatgaa      240

gggaaagacg gcccggcatt aactaatggt attttaaata ctgggaaaaa attacttggt      300

cttaccgaac gaggtttaac tttatttgct ccggaattag ataaatggat tcaaggtaat      360

aaacatttaa gtaattctgt gggtagtact ggaaatttga caaaagcgat agataaggtt      420

cagagtgttc ttggtacgtt acaagcgttt ttgaacaccg cattttcggg catggattta      480

gatgccttaa ttaaagcccg tcaaaatggt aaaaatgtaa cagatgtaca gctagcaaaa      540

gccagtctta acctgattaa tgaattgatt ggtactattt ctagcattac aaataatgta      600

gatacttttt ctaaacaact taataagtta ggtgaagcac taggacaagt aaaacatttt      660

ggtagttttg gagataaatt aaagaattta cctaagttag gtaatcttgg aaaaggttta      720

ggtgcattat ccggtgtatt gtcggctata tcagcggctc tattacttgc aaataaagat      780

gctgatactg caacgaaagc agcggctgca gctgaattga caaataaagt gctaggtaac      840

atcggtaaag cgatcacaca atacttgatt gctcaacgtg ctgcagcggg gctttctact      900

acgggacctg tcgcagggtt aattgcctct gtggtcagct tggcaatcag ccctttgtct      960

ttcctaggta ttgcgaaaca atttgatcgt gcgagaatgc ttgaggaata ctcgaaacgc     1020

tttaagaaat ttggttataa cggcgatagt ttacttggtc aattctacaa aaatacaggg     1080

atcgcagatg ctgcgattac aacgattaac actgtattaa gtgctattgc agcaggggtt     1140

ggtgcagcct ccgccggttc tttagttggt gcgccaatcg gtttgttagt gagtgcgatt     1200

accagcttaa tttcaggaat tcttgatgct tctaaacaag ccgtttttga acatatcgcg     1260

aatcagctcg ccgataaaat taaagcatgg gagaataagt acggtaagaa ttactttgaa     1320

aatggctatg atgcccgtca ttccgccttc ttggaagatt cactaaaatt atttaatgag     1380

ttacgtgaaa aatataaaac cgaaaatata ttatctatca ctcaacaagg ttgggatcag     1440

cgcattggtg aattagcagg tatcactcgt aatggagatc gtattcaaag tggtaaagct     1500

tatgtggatt atttgaaaaa gggtgaggag cttgcaaagc atagcgataa attcactaaa     1560

cagattttag atccaatcaa aggtaatatt gatctttcgg gtataaaagg ttctaccact     1620

ctaacttttt taaatccgtt gttaaccgca ggtaaggaag aacggaaaac acgtcagtca     1680

ggtaaatatg aatttattac tgaattaaaa gtaaaaggac gtaccgattg gaaggtaaaa     1740

ggtgttccta attctaatgg tgtatatgat ttttctaact taattcaaca tgccgttaca     1800

cgtgataata aagttctaga agcaagatta attgctaatt tgggtgctaa agatgattat     1860

gtttttgtcg gatccggttc aacaatagtt aatgctggag acggttatga tgtggtggac     1920

tatagtaaag gtcgcaccgg tgcattaaca atcgacggtc gtaatgctac taaagccgga     1980

caatataagg ttgaaagaga tcttagcggt actcaagtct tgcaggaaac cgtatcaaag     2040

caagaaacta aacgagggaa ggttaccgat ctacttgaat atcgtaacta taaattagat     2100

tactattata cgaataaggg ctttaaagct catgatgaat taaactcagt agaggaaatt     2160

atcggcagca cactacgtga taaattttat ggttctaaat ttaatgatgt tttccatggt     2220

cacgatggcg atgatttgat ttatggttat gatggcgatg atcgtttgta tggcgataat     2280

gggaatgacg aaattcatgg cggccaaggt aatgataagc tctatggtgg tgccggtaac     2340

gataggctct ttggtgaata tggcaacaac tatcttgacg gtggagaagg cgacgaccac     2400

ttagagggag gcaatggttc cgatattcta agaggtggaa gtggcaatga taagttgttt     2460

ggaaaccaag gagatgattt acttgacggt ggagaaggcg atgaccaact tgccggtgga     2520

gaaggaaatg atatttatgt ttaccgtaaa gaatatgggc accacactat tacggaacat     2580

agcggtgata aagataaatt atcattagca aatatcaatc tcaaagatgt gtcatttgag     2640

cgtaacggca atgatctact attgaaaaca aataatagaa cagcagtaac atttaaagga     2700

tggtttagta aacctaattc atcggcagga ttagatgagt atcaaagaaa acttcttgaa     2760

tacgcacctg aaaaggatcg tgcacgactt aagagacaat ttgagttaca gcgaggtaaa     2820

gtcgacaaat cactcaataa taaagttgaa gaaattatcg gtaaagatgg ggagcggatt     2880

acttcgcaag acattgataa tctttttgat aagagtggga acaaaaagac aatttcacct     2940

caagagcttg ccggacttat taagaataaa ggtaagtcaa gtagccttat gtcttcttct     3000

cgttcgtcaa gtatgcttac acaaaagtcc ggtttgtcaa atgatattag tcgtattatt     3060

tcagcaacca gtggttttgg ttcatccggt aaagcgttat ccgcttcgcc attgcagacc     3120

aataataact ttaactctta cgcaaattcg ttagcaacta ctgcggcc                  3168


