                               SEQUENCE LISTING

<110> Eisai R&D Management Co., Ltd.et al.
 
<120> METHODS AND COMPOSITIONS FOR PREDICTING RESPONSE TO ERIBULIN

<130> 117824-12320

<140> NEW APPLICATION
<141> Concurrently Herewith

<150> 61/454,426
<151> 2011-03-18

<160> 80    

<170> PatentIn version 3.5

<210> 1
<211> 2129
<212> DNA
<213> Homo sapiens

<400> 1
tcctatccac cctccactcc cctgtccctt ggtgactcat ccctgagctt cccaaggaag       60

cccccaccct ctgccctttc ctcccgcctt ccatgagtgg aaaatccacc tccgccccct      120

atagcaggcc agcccccttc ctccccagtc tccgacccca tcccccagcc gaccagtttc      180

ctctccagga ccagggagca atcacagctg ccccgacctt ggcttcctct gctgggtggg      240

attgggggct gggcccccaa atgggcccct ggcttccccc ttcctctggg caggggacag      300

agagacacag gctcggggag caggactgac ttcctcttgt cccggaatga gcatgcctgc      360

cctttgcaag caggtttggg tctcacgcag aggaaaccaa aagcaataag agggagggaa      420

ggcagagcaa ccaatcaagg gcagggtgag actcaaaacg agcgggctcc ctggggagcc      480

agacagaggc tgggggtgat ggcggagcta cagcagctgc aggagtttga gatccccact      540

ggccgggagg ctctgagggg caaccacagt gccctgctgc gggtcgctga ctactgcgag      600

gacaactatg tgcaggccac agacaagcgg aaggcgctgg aggagaccat ggccttcact      660

acccaggcac tggccagcgt ggcctaccag gtgggcaacc tggccgggca cactctgcgc      720

atgttggacc tgcagggggc cgccctgcgg caggtggaag cccgtgtaag cacgctgggc      780

cagatggtga acatgcatat ggagaaggtg gcccgaaggg agatcggcac cttagccact      840

gtccagcggc tgccccccgg ccagaaggtc atcgccccag agaacctacc ccctctcacg      900

ccctactgca ggagacccct caactttggc tgcctggacg acattggcca tgggatcaag      960

gacctcagca cgcagctgtc aagaacaggc accctgtctc gaaagagcat caaggcccct     1020

gccacacccg cctccgccac cttggggaga ccaccccgga ttcccgagcc agtgcacctg     1080

ccggtggtgc ccgacggcag actctccgcc gcctcctctg cgtcttccct ggcctcggcc     1140

ggcagcgccg aaggtgtcgg tggggccccc acgcccaagg ggcaggcagc acctccagcc     1200

ccacctctcc ccagctcctt ggacccacct cctccaccag cagccgtcga ggtgttccag     1260

cggcctccca cgctggagga gttgtcccca cccccaccgg acgaagagct gcccctgcca     1320

ctggacctgc ctcctcctcc acccctggat ggagatgaat tggggctgcc tccaccccca     1380

ccaggatttg ggcctgatga gcccagctgg gtgcctgcct catacttgga gaaagtggtg     1440

acactgtacc catacaccag ccagaaggac aatgagctct ccttctctga gggcactgtc     1500

atctgtgtca ctcgccgcta ctccgatggc tggtgcgagg gcgtcagctc agaggggact     1560

ggattcttcc ctgggaacta tgtggagccc agctgctgac agcccagggc tctctgggca     1620

gctgatgtct gcactgagtg ggtttcatga gccccaagcc aaaaccagct ccagtcacag     1680

ctggactggg tctgcccacc tcttgggctg tgagctgtgt tctgtccttc ctcccatcgg     1740

agggagaagg ggtcctgggg agagagaatt tatccagagg cctgctgcag atggggaaga     1800

gctggaaacc aagaagtttg tcaacagagg acccctactc catgcaggac agggtctcct     1860

gctgcaagtc ccaactttga ataaaacaga tgatgtcctg tgactgcccc acagagataa     1920

ggggccagga gggattgaaa ggcatcccag ttctaaggct gctgctaatt acagccccca     1980

acctccaacc caccagctga cctagaagca gcatcttccc atttcctcag tacccacaaa     2040

gtgcagccca cattggaccc cagacacccc tctgcagcca ttgactgcaa cttgttcttt     2100

tgcccattga aaaaaaaaaa aaaaaaaaa                                       2129


<210> 2
<211> 366
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Glu Leu Gln Gln Leu Gln Glu Phe Glu Ile Pro Thr Gly Arg 
1               5                   10                  15      


Glu Ala Leu Arg Gly Asn His Ser Ala Leu Leu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asp Asn Tyr Val Gln Ala Thr Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Thr Met Ala Phe Thr Thr Gln Ala Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Val Gly Asn Leu Ala Gly His Thr Leu Arg Met Leu Asp Leu Gln Gly 
65                  70                  75                  80  


Ala Ala Leu Arg Gln Val Glu Ala Arg Val Ser Thr Leu Gly Gln Met 
                85                  90                  95      


Val Asn Met His Met Glu Lys Val Ala Arg Arg Glu Ile Gly Thr Leu 
            100                 105                 110         


Ala Thr Val Gln Arg Leu Pro Pro Gly Gln Lys Val Ile Ala Pro Glu 
        115                 120                 125             


Asn Leu Pro Pro Leu Thr Pro Tyr Cys Arg Arg Pro Leu Asn Phe Gly 
    130                 135                 140                 


Cys Leu Asp Asp Ile Gly His Gly Ile Lys Asp Leu Ser Thr Gln Leu 
145                 150                 155                 160 


Ser Arg Thr Gly Thr Leu Ser Arg Lys Ser Ile Lys Ala Pro Ala Thr 
                165                 170                 175     


Pro Ala Ser Ala Thr Leu Gly Arg Pro Pro Arg Ile Pro Glu Pro Val 
            180                 185                 190         


His Leu Pro Val Val Pro Asp Gly Arg Leu Ser Ala Ala Ser Ser Ala 
        195                 200                 205             


Ser Ser Leu Ala Ser Ala Gly Ser Ala Glu Gly Val Gly Gly Ala Pro 
    210                 215                 220                 


Thr Pro Lys Gly Gln Ala Ala Pro Pro Ala Pro Pro Leu Pro Ser Ser 
225                 230                 235                 240 


Leu Asp Pro Pro Pro Pro Pro Ala Ala Val Glu Val Phe Gln Arg Pro 
                245                 250                 255     


Pro Thr Leu Glu Glu Leu Ser Pro Pro Pro Pro Asp Glu Glu Leu Pro 
            260                 265                 270         


Leu Pro Leu Asp Leu Pro Pro Pro Pro Pro Leu Asp Gly Asp Glu Leu 
        275                 280                 285             


Gly Leu Pro Pro Pro Pro Pro Gly Phe Gly Pro Asp Glu Pro Ser Trp 
    290                 295                 300                 


Val Pro Ala Ser Tyr Leu Glu Lys Val Val Thr Leu Tyr Pro Tyr Thr 
305                 310                 315                 320 


Ser Gln Lys Asp Asn Glu Leu Ser Phe Ser Glu Gly Thr Val Ile Cys 
                325                 330                 335     


Val Thr Arg Arg Tyr Ser Asp Gly Trp Cys Glu Gly Val Ser Ser Glu 
            340                 345                 350         


Gly Thr Gly Phe Phe Pro Gly Asn Tyr Val Glu Pro Ser Cys 
        355                 360                 365     


<210> 3
<211> 742
<212> DNA
<213> Homo sapiens

<400> 3
tccaggttca cacaactgga acccatctcc aggaacaaac agctggaacc catctcccgt       60

tgaagggaaa ctgccagatt tttgtaagat tcttcctcct gggagcctgt gttggaagag      120

atggtgatgg gcctgggcgt tttgttgttg gtcttcgtgc tgggtctggg tctgacccca      180

ccgaccctgg ctcaggataa ctccaggtac acacacttcc tgacccagca ctatgatgcc      240

aaaccacagg gccgggatga cagatactgt gaaagcatca tgaggagacg gggcctgacc      300

tcaccctgca aagacatcaa cacatttatt catggcaaca agcgcagcat caaggccatc      360

tgtgaaaaca agaatggaaa ccctcacaga gaaaacctaa gaataagcaa gtcttctttc      420

caggtcacca cttgcaagct acatggaggt tccccctggc ctccatgcca gtaccgagcc      480

acagcggggt tcagaaacgt tgttgttgct tgtgaaaatg gcttacctgt ccacttggat      540

cagtcaattt tccgtcgtcc gtaaccagcg ggcccctggt caagtgctgg ctctgctgtc      600

cttgccttcc atttcccctc tgcacccaga acagtggtgg caacattcat tgccaagggc      660

ccaaagaaag agctacctgg accttttgtt ttctgtttga caacatgttt aataaataaa      720

aatgtcttga tatcagtaag aa                                               742


<210> 4
<211> 147
<212> PRT
<213> Homo sapiens

<400> 4
Met Val Met Gly Leu Gly Val Leu Leu Leu Val Phe Val Leu Gly Leu 
1               5                   10                  15      


Gly Leu Thr Pro Pro Thr Leu Ala Gln Asp Asn Ser Arg Tyr Thr His 
            20                  25                  30          


Phe Leu Thr Gln His Tyr Asp Ala Lys Pro Gln Gly Arg Asp Asp Arg 
        35                  40                  45              


Tyr Cys Glu Ser Ile Met Arg Arg Arg Gly Leu Thr Ser Pro Cys Lys 
    50                  55                  60                  


Asp Ile Asn Thr Phe Ile His Gly Asn Lys Arg Ser Ile Lys Ala Ile 
65                  70                  75                  80  


Cys Glu Asn Lys Asn Gly Asn Pro His Arg Glu Asn Leu Arg Ile Ser 
                85                  90                  95      


Lys Ser Ser Phe Gln Val Thr Thr Cys Lys Leu His Gly Gly Ser Pro 
            100                 105                 110         


Trp Pro Pro Cys Gln Tyr Arg Ala Thr Ala Gly Phe Arg Asn Val Val 
        115                 120                 125             


Val Ala Cys Glu Asn Gly Leu Pro Val His Leu Asp Gln Ser Ile Phe 
    130                 135                 140                 


Arg Arg Pro 
145         


<210> 5
<211> 8935
<212> DNA
<213> Homo sapiens

<400> 5
gccaaagcct ggagaagtgg aatctcgtca gcgccgctcc ctgcgcggga ctcgcggaac       60

ggcactgagc atgctcagtt gccggagccc gttctggtct caagtaggaa gctagtgcgc      120

tgtaaccgca tctgatctgg gcgctccggg aagggcgaga ctggagcaga gccgctgggc      180

gccggagccg aggcgagcgc cgcgcgcacc actggttgga gttgctgtgg gtgagctgct      240

gtggtctgta gccaagcatg ctgtggtcgg atctgcccag ccgtggaaca gaaacatttg      300

ctggatggaa aatccataaa agaaagctcc tgtgaaaagc tgaggctgac aataatttaa      360

gcaaaatcag atcgatctct ttgggctgcc tgacctcctt gggtgcttgc tattaattaa      420

cagactttgt ggggaaaaaa aggagcttgc cttctgagct ttgtaccaaa gacctgggaa      480

aactaaccat ctcagtcttt cctgaggact tgggaactgc cgaggcctct gccaatgtgt      540

tgactgtcgc tatgggctca ctgttgtcca ggcagctcat atttcaaatt ataacctatt      600

tcctgcacca ttgctgacgc ctggtgatcc atgtcagaag tacttccagc tgactcaggt      660

gttgacacct tggcagtgtt tatggccagc agcggaacta cagacgtcac aaatcggaac      720

agcccagcca caccaccaaa cacccttaac ctccgatcct cccacaatga actgttgaac      780

gctgaaataa aacacacaga aaccaagaac agcacacctc ccaaatgcag gaaaaaatat      840

gcactaacta acatccaggc ggccatgggc ctctcggatc cagctgcaca gcccctgctg      900

ggaaatggct ctgccaacat caagctggtg aaaaatgggg agaaccagct ccgtaaggct      960

gcagagcaag ggcagcagga ccccaacaaa aacctgagcc ccactgcagt catcaacata     1020

acttctgaga agttagaggg taaagagccc cacccacagg attcctcgag ctgtgagatt     1080

ttaccctccc agcccaggag aactaagagc ttcctaaatt actatgcaga tctggaaacc     1140

tcagccagag aactagagca gaaccgaggc aatcaccatg ggactgcgga agagaaatcc     1200

cagccagtcc agggccaggc ctccaccatc attgggaatg gcgatttgct gctgcagaaa     1260

ccaaacagac cccagtccag ccctgaagac ggccaagtag ccacagtgtc atccagccca     1320

gaaaccaaga aggatcatcc gaaaacaggg gccaaaaccg actgtgcact gcaccggatc     1380

cagaacctgg caccgagcga tgaggagtcc agctggacaa cgttgtccca agacagtgcc     1440

tcacccagct ccccggatga aacagatata tggagtgatc actcatttca gactgatcca     1500

gatttgccgc ctggctggaa aagagtcagt gacattgccg ggacctatta ttggcacatc     1560

ccaacaggaa cgactcagtg ggaacggccc gtctccatcc cagcagatct ccagggttct     1620

aggaaagggt cacttagttc tgtaacgcca tctcccaccc cagagaacga ggatttgcat     1680

gcagccactg ttaacccgga ccccagttta aaagagtttg aaggagcaac cctacgctat     1740

gcatctttga aactcagaaa tgccccacac cctgatgatg atgattcttg tagtatcaac     1800

agtgacccag aagccaagtg ttttgctgtg cgttctctgg gatgggtaga gatggcagaa     1860

gaggacctcg cccccggtaa aagtagtgtt gcggtcaaca actgcatcag gcaactttcc     1920

tactgcaaaa atgacatccg agacacagtc gggatttggg gagaggggaa agacatgtac     1980

ctgatcctgg agaatgacat gctcagcctg gtggacccca tggaccgcag cgtgctgcac     2040

tcgcagccca tcgtcagcat ccgcgtgtgg ggcgtgggcc gcgacaatgg ccgggatttt     2100

gcttatgtag caagagataa agatacaaga attttgaaat gtcatgtatt tcgatgtgac     2160

acaccagcaa aagccattgc cacaagtctc cacgagatct gctccaagat tatggctgaa     2220

cggaagaatg ccaaagcgct ggcctgcagc tccttacagg aaagggccaa tgtgaacctc     2280

gatgtccctt tgcaagattt tccaacacca aagactgagc tggtccagaa gttccacgtg     2340

cagtacttgg gcatgttacc tgtagacaaa ccagtcggaa tggatatttt gaacagtgcc     2400

atagaaaatc ttatgacctc atccaacaag gaggactggc tgtcagtgaa catgaacgtg     2460

gctgatgcca ctgtgactgt catcagtgaa aagaatgaag aggaagtctt agtggaatgt     2520

cgtgtgcgat tcctgtcctt catgggtgtt gggaaggacg tccacacatt tgccttcatc     2580

atggacacgg ggaaccagcg ctttgagtgc cacgttttct ggtgcgagcc taatgctggt     2640

aacgtgtctg aggcggtgca ggccgcctgc atgttacgat atcagaagtg cttggtagcc     2700

aggccgcctt ctcagaaagt tcgaccacct ccaccgccag cagattcagt aaccagaaga     2760

gtcacaacca atgtaaaacg aggggtctta tccctcattg acactttgaa acagaaacgc     2820

cctgtcaccg aaatgccata gctgcacatg caaaaggact cggctattta cctgaagatt     2880

gactagctac actaaagaaa atgaactccg ccatccgacc ttccatccag ttgctgatgc     2940

tttgtcttca gagaatttac ccttaaccaa gcagtgttag acaagcatgt tctctcgtct     3000

tgccaccatc atgtgatatg aaaagaagca tgaataattt tttttgctgt aagttacatc     3060

atgcgcagtg gaaggtcttt ttcttattgt aaatattgtg aacattactt aacttcacac     3120

acacacagag aagagtgtgg ccccacccct cctagtgaac taacgctgcg tccttggaat     3180

gaatgatgcg tgagttagtt tcactgtctt cttggctgga cctgtcacaa gcaaccttta     3240

agtcctacag cactttgccc tgttttcaac attggagtag gcactgcata gcagatacca     3300

ttgaattgct gtaaaaatag gatggcgagt ttgtgtttta atttttcata aaattgaacc     3360

tgttggttga caaaattggc tgttggcatc agtatagaaa ccaactggca gctttccctg     3420

acaagctctt tgacacatgg acaccatttc atgtctacag ctgtttgtgg gatgttggaa     3480

aaaaatgaaa cttcaaaatt gatgaaaaac taaattcgag gaattaaaat cgaacaaaac     3540

atagcctttc ttttccgatg gttttcaaac tgattatttt taaaagagat taataaaatc     3600

ataatgcatt ttgggtggga catatttcaa acttctgcct tatattgtac ggtgcagcta     3660

gagaattata gttcactatg gccattctct acataaacat taagatgaaa tactcctcat     3720

cagcctttca tccttagttt gagaattagc tgatatgcaa tttgaagttg aggaaatatc     3780

attgatattt ctatcatgca cgattatttt agatttctac caccgtgtga tttttgctag     3840

tccatgtgct agaggtaaac gttctgctgg aattctgcat ccagctctat ccccctctga     3900

tgctttttgc ccagaaagct gtctgtccat catgtattgt ccatggcaac aaattacatt     3960

aggttgaacc tttccttgat tttatgtatt taatattaga atttgttgga ctcaactaga     4020

tatatttttt aatttatatt ttttccattt tactttgaag atttgaaatg ttcatacctg     4080

agcaaagtct acacaggagt aatggactgt ttaacaagtt tcccaaaaca gcattttcct     4140

gctccttcgt atgtaggtga gaaacttagc tggaaagaca tacaaattta gactctcgtt     4200

gacattgtcg ttttaaaagg aagttgctaa ggcgatcaat ctcaatatta gtcttgttta     4260

cttcttctta atgtcaaaat taacatttac aacatccaat tataaaagta atgctttatg     4320

tttatacact gctatgtact tgtcaaaatg gtttccacat tcttatcaca tctgagcctt     4380

accaggtaga gaaggtacta aatacacttt agaagtaaaa atatgaagta ccgagaggct     4440

aaacccactg gcctaagatc tcaccaaagt tcatgaaaac caggactagg acccacggct     4500

cccaaagccc gttcttgctg tgttgtgctg cctccatatc cgtcaggaag agcctttcca     4560

gaatgattct gggcatatac taagaagagc aggtatggaa agatctattg tcagggaatc     4620

ttagaattcc ctacacgagt gggagaaaga tgtccaaatt ccttacgcag tggtattcat     4680

gatggtgccc tatctaagtc caggactgtt ttcctacagc gtgcctcaaa agtgttgtag     4740

agggcaggat tctacattca cagcctgttc catctacgag attttccaga tgctacttgt     4800

ggtagacatt cctaactcat ggtacttagc caccagagat catgatggaa tgagtgggtg     4860

gcttttctac ctgccattcc ctcagaattc atgaggggtg ggggacaggg ggaccggaat     4920

tgtcttagca ccccaatgtt atgacaaaac tatgctactt tagaaacgca gtctgttttt     4980

caccaattga catactactg atctgaagta accagtgcca tcataagaaa ttactgcatt     5040

aagaaaatcc ttgctgtgcc ctttgaaaag ctgttcagaa atcatttaca gtgatctttc     5100

atctcggtcg ctgtagtgaa acattttagt gtgataaatt tcaaaattct aaacaaatta     5160

cccactttta tattggaaat ctctaccaga actccctctt cattttttaa ggcatacatt     5220

tgcttgtttt caagatcaag aattctgagc tagctttaag tagcaaactg atttatatgt     5280

gcaattatag gatgcattaa gatgaatgat agcctttaca tattgaaaac tttgcagacg     5340

ttttgttttg aaaatggcat tgtatagtaa atgcaaatta attttgtaaa attatgttaa     5400

agagtatgtt cagacacttt ctgccatggc caaaaagtat gtatgaaagt atgtgtgtat     5460

ttgtttgtaa aaggatgcca atgttttacc tgatatctta gtgacacttc agttatctat     5520

gcattcttta gatctgtgat tcggtaaaca ggcagccatg ttcacgatgc cttctatgtc     5580

ttaccatatt tttaattaac ctgttaaata cagcttaaaa tatttttatt ttatttattc     5640

tatttttact gaaatatact gcattattgt gttaatgtat tatctttcct ggatattatc     5700

tcccagtgta tccagatcta agtaatctca gtgaactata cattgcctaa aaagtggttt     5760

tgtaatgatt tgtagtcaca tttctattgg gatatgtaga agaaaaggca aaatgcttaa     5820

agttcctttt attttttaaa agcagctaga tagacacaga cttgccacct catacatctg     5880

ctccttggca acatcaaggg gaacgactag ccaacatgcc tatggctaaa aactttcctt     5940

tgcagactaa agcactgctt ggtgcttcgt ttttctaccc ttcacaacat gtgtgatttc     6000

atctaagaga tatatacatg tacacatgcc ctttgtttcc acctggatac aagatcactc     6060

atagctaatt aggaccattg ttttttgttc atctgtcttg ttgcatgaag ggacattaga     6120

cccatttcca ttaaaataag ttcttggtga taaactgtgg cactgctact tctttttaaa     6180

tccactttat gatttcaaga tggacacttg taagatgact cgacacaagg ccattgcctg     6240

gaagccccag agctttcctc tgtttgtatg gcccgttcat gtcccaggca ttgcaacaca     6300

aactcctcaa gatttcacca caacatgaca agcattttcc taactgatat tagcacaatt     6360

taactaataa gccccttcgc tctctagttg gccaggctta acctaataca catctaacgt     6420

gtgtgccaca cggccagtag aaagtttaac ttcagcttca gggcaaagat acccactcac     6480

accgtgtcaa cgcaagcagt agttcctggc ctccagagca gcttacttcc cctgaaagaa     6540

cgctttgttt tcctttatgc ccttttcctg ttgaccactt ttacacattt aaatgtaatt     6600

tgttgtgaga ataaatttag ctgcataaaa cgttcggctc atttatctga catcttagtc     6660

acatatacaa ggaatagaaa tagaaactcg gtgtctctag ttatttttaa attattctta     6720

cctcagactt cttagaaatc actttagtaa tggagcattt tgctttgatt agttactaca     6780

tatttctgcc tggtaagaac taggaagtaa cttcaaattt tgagtaatca ccctgtactt     6840

atttggtgat caggaaggcc agctggcctt ccggacatag aagcctattt agtcaccaac     6900

tcgagtcttt tgtaagcggt cttgctagga ttgtgatatt ttagcacgaa gaagtttatc     6960

acttccttta agaacctgac atcaaagaat aaagaataga ggtgtacaca cactaaatcc     7020

aaaatgaaag gtaactagag aaatcagttg aatctggttt agcttaactg ttaggcgcag     7080

gaaggcagat aaacagaatt taaagtatgt ccccgctttt tgttcatctt gcacttccac     7140

agtggtttct ctctagtcag taacaaaatt tcattatggt ttcaggcatt atatggtggt     7200

aaataatttc agattaaaaa tgtgtttgct attggagtat ctgaatacta gtaatttcat     7260

tatttagaat tttgcagcac ttttatctca agaagaagtc caagaatgta aaatgccaaa     7320

tgaaacatgt cagtggaatc aatattctcc ttcattagaa ttccctcata ttgctttttt     7380

tttttttctt cagacagagg agtcttactc tggagtgcag tggtgtaatt tcagctcacc     7440

acaacctcca cctcccaagt tcaagcaatt ctcgcctcag cctcctgagt agctgggatt     7500

acaggcatgc accgccacgc ctggccaatt tgtatatttt tagtagagac agggtttcgc     7560

cacgttggcc aggctggtct cgaactcctg acctcaggtg atccgcccgc cccaacctcc     7620

caaagtatgt gagccaccac gtccggcctc atattgcttt tatccaaaat tcttttccct     7680

tttcactcta ccaaagtatt taaataatcc tgtccttcat agaagattct caaagaagaa     7740

aactgcagtg taattaatga atggtttaat tcagaatctt catatacttc taaagagaaa     7800

aataatttag tgccaaatgc atgttaggag ataatcaatg taagtggcaa caaattgtga     7860

cttcacatgc tactgtagag atcagaaaat tatcctaaac tattccataa caatgagaca     7920

acatcacaga aaatacactt gaaaataaaa atctcaagac cagctacttc tggacaatgg     7980

aatacttttc agtctggtat ggtggagggc ccgaaaagga taagggattc ttatgataca     8040

caatgggatt ctttactgaa caatatgtta aattaagctg caccgccttc cttgaggcat     8100

ggactaccct aaccaaccag atagaaatct gggtgggata agaggatgag ccacacgcta     8160

taattttagg gcaaggagat agtgtttgat tttcaaaatc agcaaaataa gctgagcact     8220

ttatatcttt ctgtacaaga gtgataacat gaagaattct tcttcaggga tttaaaatac     8280

aataagcctg gttcaactat aaaaagtctt gtttcctttc ttcattgaca cttttttttt     8340

tttttttttt tttttgaggc aaggtctcac tctgcttccc aggctggagt gcagtggggc     8400

aatattggct cactgcaacc tgcacctcct ggactcaaga gatcctcgta cctcagcctc     8460

ctaagtagct gggactacag gcgtgtccca ccacacccag ctaatttttg tattttttgt     8520

agagatgggg ttttggggtt tcgccatgtt gtccaggctc gtctggaact ccggtgctca     8580

agtggcgtgc ccacctcagc ctcccaaact gctgagatta cagatgtgag ccactgcacc     8640

cagcccactg acacgtttta ctgataaatg taaatctaag ctaaaataaa aataatgtat     8700

taccgctata atacaattca ccattctctt ttctcacttc aagtaagaaa gtaaaaatag     8760

aatatcagag ctgaagtaga cctaagtatt catcttgaag aagataatat tctaaaaatc     8820

atgccacctg aattgagcat ttaggaattt atgtaacatt tctatacaac tgaattgcaa     8880

aaataaaact ttaaattcaa actttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa          8935


<210> 6
<211> 736
<212> PRT
<213> Homo sapiens

<400> 6
Met Ser Glu Val Leu Pro Ala Asp Ser Gly Val Asp Thr Leu Ala Val 
1               5                   10                  15      


Phe Met Ala Ser Ser Gly Thr Thr Asp Val Thr Asn Arg Asn Ser Pro 
            20                  25                  30          


Ala Thr Pro Pro Asn Thr Leu Asn Leu Arg Ser Ser His Asn Glu Leu 
        35                  40                  45              


Leu Asn Ala Glu Ile Lys His Thr Glu Thr Lys Asn Ser Thr Pro Pro 
    50                  55                  60                  


Lys Cys Arg Lys Lys Tyr Ala Leu Thr Asn Ile Gln Ala Ala Met Gly 
65                  70                  75                  80  


Leu Ser Asp Pro Ala Ala Gln Pro Leu Leu Gly Asn Gly Ser Ala Asn 
                85                  90                  95      


Ile Lys Leu Val Lys Asn Gly Glu Asn Gln Leu Arg Lys Ala Ala Glu 
            100                 105                 110         


Gln Gly Gln Gln Asp Pro Asn Lys Asn Leu Ser Pro Thr Ala Val Ile 
        115                 120                 125             


Asn Ile Thr Ser Glu Lys Leu Glu Gly Lys Glu Pro His Pro Gln Asp 
    130                 135                 140                 


Ser Ser Ser Cys Glu Ile Leu Pro Ser Gln Pro Arg Arg Thr Lys Ser 
145                 150                 155                 160 


Phe Leu Asn Tyr Tyr Ala Asp Leu Glu Thr Ser Ala Arg Glu Leu Glu 
                165                 170                 175     


Gln Asn Arg Gly Asn His His Gly Thr Ala Glu Glu Lys Ser Gln Pro 
            180                 185                 190         


Val Gln Gly Gln Ala Ser Thr Ile Ile Gly Asn Gly Asp Leu Leu Leu 
        195                 200                 205             


Gln Lys Pro Asn Arg Pro Gln Ser Ser Pro Glu Asp Gly Gln Val Ala 
    210                 215                 220                 


Thr Val Ser Ser Ser Pro Glu Thr Lys Lys Asp His Pro Lys Thr Gly 
225                 230                 235                 240 


Ala Lys Thr Asp Cys Ala Leu His Arg Ile Gln Asn Leu Ala Pro Ser 
                245                 250                 255     


Asp Glu Glu Ser Ser Trp Thr Thr Leu Ser Gln Asp Ser Ala Ser Pro 
            260                 265                 270         


Ser Ser Pro Asp Glu Thr Asp Ile Trp Ser Asp His Ser Phe Gln Thr 
        275                 280                 285             


Asp Pro Asp Leu Pro Pro Gly Trp Lys Arg Val Ser Asp Ile Ala Gly 
    290                 295                 300                 


Thr Tyr Tyr Trp His Ile Pro Thr Gly Thr Thr Gln Trp Glu Arg Pro 
305                 310                 315                 320 


Val Ser Ile Pro Ala Asp Leu Gln Gly Ser Arg Lys Gly Ser Leu Ser 
                325                 330                 335     


Ser Val Thr Pro Ser Pro Thr Pro Glu Asn Glu Asp Leu His Ala Ala 
            340                 345                 350         


Thr Val Asn Pro Asp Pro Ser Leu Lys Glu Phe Glu Gly Ala Thr Leu 
        355                 360                 365             


Arg Tyr Ala Ser Leu Lys Leu Arg Asn Ala Pro His Pro Asp Asp Asp 
    370                 375                 380                 


Asp Ser Cys Ser Ile Asn Ser Asp Pro Glu Ala Lys Cys Phe Ala Val 
385                 390                 395                 400 


Arg Ser Leu Gly Trp Val Glu Met Ala Glu Glu Asp Leu Ala Pro Gly 
                405                 410                 415     


Lys Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln Leu Ser Tyr Cys 
            420                 425                 430         


Lys Asn Asp Ile Arg Asp Thr Val Gly Ile Trp Gly Glu Gly Lys Asp 
        435                 440                 445             


Met Tyr Leu Ile Leu Glu Asn Asp Met Leu Ser Leu Val Asp Pro Met 
    450                 455                 460                 


Asp Arg Ser Val Leu His Ser Gln Pro Ile Val Ser Ile Arg Val Trp 
465                 470                 475                 480 


Gly Val Gly Arg Asp Asn Gly Arg Asp Phe Ala Tyr Val Ala Arg Asp 
                485                 490                 495     


Lys Asp Thr Arg Ile Leu Lys Cys His Val Phe Arg Cys Asp Thr Pro 
            500                 505                 510         


Ala Lys Ala Ile Ala Thr Ser Leu His Glu Ile Cys Ser Lys Ile Met 
        515                 520                 525             


Ala Glu Arg Lys Asn Ala Lys Ala Leu Ala Cys Ser Ser Leu Gln Glu 
    530                 535                 540                 


Arg Ala Asn Val Asn Leu Asp Val Pro Leu Gln Asp Phe Pro Thr Pro 
545                 550                 555                 560 


Lys Thr Glu Leu Val Gln Lys Phe His Val Gln Tyr Leu Gly Met Leu 
                565                 570                 575     


Pro Val Asp Lys Pro Val Gly Met Asp Ile Leu Asn Ser Ala Ile Glu 
            580                 585                 590         


Asn Leu Met Thr Ser Ser Asn Lys Glu Asp Trp Leu Ser Val Asn Met 
        595                 600                 605             


Asn Val Ala Asp Ala Thr Val Thr Val Ile Ser Glu Lys Asn Glu Glu 
    610                 615                 620                 


Glu Val Leu Val Glu Cys Arg Val Arg Phe Leu Ser Phe Met Gly Val 
625                 630                 635                 640 


Gly Lys Asp Val His Thr Phe Ala Phe Ile Met Asp Thr Gly Asn Gln 
                645                 650                 655     


Arg Phe Glu Cys His Val Phe Trp Cys Glu Pro Asn Ala Gly Asn Val 
            660                 665                 670         


Ser Glu Ala Val Gln Ala Ala Cys Met Leu Arg Tyr Gln Lys Cys Leu 
        675                 680                 685             


Val Ala Arg Pro Pro Ser Gln Lys Val Arg Pro Pro Pro Pro Pro Ala 
    690                 695                 700                 


Asp Ser Val Thr Arg Arg Val Thr Thr Asn Val Lys Arg Gly Val Leu 
705                 710                 715                 720 


Ser Leu Ile Asp Thr Leu Lys Gln Lys Arg Pro Val Thr Glu Met Pro 
                725                 730                 735     


<210> 7
<211> 562
<212> DNA
<213> Homo sapiens

<400> 7
ctggaattga ggctgagcca aagaccccag ggccgtctca gtctcataaa aggggatcag       60

gcaggaggag tttgggagaa acctgagaag ggcctgattt gcagcatcat gatgggcctc      120

tccttggcct ctgctgtgct cctggcctcc ctcctgagtc tccaccttgg aactgccaca      180

cgtgggagtg acatatccaa gacctgctgc ttccaataca gccacaagcc ccttccctgg      240

acctgggtgc gaagctatga attcaccagt aacagctgct cccagcgggc tgtgatattc      300

actaccaaaa gaggcaagaa agtctgtacc catccaagga aaaaatgggt gcaaaaatac      360

atttctttac tgaaaactcc gaaacaattg tgactcagct gaattttcat ccgaggacgc      420

ttggaccccg ctcttggctc tgcagccctc tggggagcct gcggaatctt ttctgaaggc      480

tacatggacc cgctggggag gagagggtgt ttcctcccag agttacttta ataaaggttg      540

ttcatagagt tgacttgttc at                                               562


<210> 8
<211> 94
<212> PRT
<213> Homo sapiens

<400> 8
Met Met Gly Leu Ser Leu Ala Ser Ala Val Leu Leu Ala Ser Leu Leu 
1               5                   10                  15      


Ser Leu His Leu Gly Thr Ala Thr Arg Gly Ser Asp Ile Ser Lys Thr 
            20                  25                  30          


Cys Cys Phe Gln Tyr Ser His Lys Pro Leu Pro Trp Thr Trp Val Arg 
        35                  40                  45              


Ser Tyr Glu Phe Thr Ser Asn Ser Cys Ser Gln Arg Ala Val Ile Phe 
    50                  55                  60                  


Thr Thr Lys Arg Gly Lys Lys Val Cys Thr His Pro Arg Lys Lys Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Ile Ser Leu Leu Lys Thr Pro Lys Gln Leu 
                85                  90                  


<210> 9
<211> 1697
<212> DNA
<213> Homo sapiens

<400> 9
gaggcgtaag ccaggcgtgt taaagccggt cggaactgct ccggagggca cgggctccgt       60

aggcaccaac tgcaaggacc cctccccctg cgggcgctcc catggcacag ttcgcgttcg      120

agagtgacct gcactcgctg cttcagctgg atgcacccat ccccaatgca ccccctgcgc      180

gctggcagcg caaagccaag gaagccgcag gcccggcccc ctcacccatg cgggccgcca      240

accgatccca cagcgccggc aggactccgg gccgaactcc tggcaaatcc agttccaagg      300

ttcagaccac tcctagcaaa cctggcggtg accgctatat cccccatcgc agtgctgccc      360

agatggaggt ggccagcttc ctcctgagca aggagaacca gcctgaaaac agccagacgc      420

ccaccaagaa ggaacatcag aaagcctggg ctttgaacct gaacggtttt gatgtagagg      480

aagccaagat ccttcggctc agtggaaaac cacaaaatgc gccagagggt tatcagaaca      540

gactgaaagt actctacagc caaaaggcca ctcctggctc cagccggaag acctgccgtt      600

acattccttc cctgccagac cgtatcctgg atgcgcctga aatccgaaat gactattacc      660

tgaaccttgt ggattggagt tctgggaatg tactggccgt ggcactggac aacagtgtgt      720

acctgtggag tgcaagctct ggtgacatcc tgcagctttt gcaaatggag cagcctgggg      780

aatatatatc ctctgtggcc tggatcaaag agggcaacta cttggctgtg ggcaccagca      840

gtgctgaggt gcagctatgg gatgtgcagc agcagaaacg gcttcgaaat atgaccagtc      900

actctgcccg agtgggctcc ctaagctgga acagctatat cctgtccagt ggttcacgtt      960

ctggccacat ccaccaccat gatgttcggg tagcagaaca ccatgtggcc acactgagtg     1020

gccacagcca ggaagtgtgt gggctgcgct gggccccaga tggacgacat ttggccagtg     1080

gtggtaatga taacttggtc aatgtgtggc ctagtgctcc tggagagggt ggctgggttc     1140

ctctgcagac attcacccag catcaagggg ctgtcaaggc cgtagcatgg tgtccctggc     1200

agtccaatgt cctggcaaca ggagggggca ccagtgatcg acacattcgc atctggaatg     1260

tgtgctctgg ggcctgtctg agtgccgtgg atgcccattc ccaggtgtgc tccatcctct     1320

ggtctcccca ttacaaggag ctcatctcag gccatggctt tgcacagaac cagctagtta     1380

tttggaagta cccaaccatg gccaaggtgg ctgaactcaa aggtcacaca tcccgggtcc     1440

tgagtctgac catgagccca gatggggcca cagtggcatc cgcagcagca gatgagaccc     1500

tgaggctatg gcgctgtttt gagttggacc ctgcgcggcg gcgggagcgg gagaaggcca     1560

gtgcagccaa aagcagcctc atccaccaag gcatccgctg aagaccaacc catcacctca     1620

gttgtttttt atttttctaa taaagtcatg tctcccttca tgtttttttt ttaaaaaaaa     1680

aaaaaaaaaa aaaaaaa                                                    1697


<210> 10
<211> 499
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Gln Phe Ala Phe Glu Ser Asp Leu His Ser Leu Leu Gln Leu 
1               5                   10                  15      


Asp Ala Pro Ile Pro Asn Ala Pro Pro Ala Arg Trp Gln Arg Lys Ala 
            20                  25                  30          


Lys Glu Ala Ala Gly Pro Ala Pro Ser Pro Met Arg Ala Ala Asn Arg 
        35                  40                  45              


Ser His Ser Ala Gly Arg Thr Pro Gly Arg Thr Pro Gly Lys Ser Ser 
    50                  55                  60                  


Ser Lys Val Gln Thr Thr Pro Ser Lys Pro Gly Gly Asp Arg Tyr Ile 
65                  70                  75                  80  


Pro His Arg Ser Ala Ala Gln Met Glu Val Ala Ser Phe Leu Leu Ser 
                85                  90                  95      


Lys Glu Asn Gln Pro Glu Asn Ser Gln Thr Pro Thr Lys Lys Glu His 
            100                 105                 110         


Gln Lys Ala Trp Ala Leu Asn Leu Asn Gly Phe Asp Val Glu Glu Ala 
        115                 120                 125             


Lys Ile Leu Arg Leu Ser Gly Lys Pro Gln Asn Ala Pro Glu Gly Tyr 
    130                 135                 140                 


Gln Asn Arg Leu Lys Val Leu Tyr Ser Gln Lys Ala Thr Pro Gly Ser 
145                 150                 155                 160 


Ser Arg Lys Thr Cys Arg Tyr Ile Pro Ser Leu Pro Asp Arg Ile Leu 
                165                 170                 175     


Asp Ala Pro Glu Ile Arg Asn Asp Tyr Tyr Leu Asn Leu Val Asp Trp 
            180                 185                 190         


Ser Ser Gly Asn Val Leu Ala Val Ala Leu Asp Asn Ser Val Tyr Leu 
        195                 200                 205             


Trp Ser Ala Ser Ser Gly Asp Ile Leu Gln Leu Leu Gln Met Glu Gln 
    210                 215                 220                 


Pro Gly Glu Tyr Ile Ser Ser Val Ala Trp Ile Lys Glu Gly Asn Tyr 
225                 230                 235                 240 


Leu Ala Val Gly Thr Ser Ser Ala Glu Val Gln Leu Trp Asp Val Gln 
                245                 250                 255     


Gln Gln Lys Arg Leu Arg Asn Met Thr Ser His Ser Ala Arg Val Gly 
            260                 265                 270         


Ser Leu Ser Trp Asn Ser Tyr Ile Leu Ser Ser Gly Ser Arg Ser Gly 
        275                 280                 285             


His Ile His His His Asp Val Arg Val Ala Glu His His Val Ala Thr 
    290                 295                 300                 


Leu Ser Gly His Ser Gln Glu Val Cys Gly Leu Arg Trp Ala Pro Asp 
305                 310                 315                 320 


Gly Arg His Leu Ala Ser Gly Gly Asn Asp Asn Leu Val Asn Val Trp 
                325                 330                 335     


Pro Ser Ala Pro Gly Glu Gly Gly Trp Val Pro Leu Gln Thr Phe Thr 
            340                 345                 350         


Gln His Gln Gly Ala Val Lys Ala Val Ala Trp Cys Pro Trp Gln Ser 
        355                 360                 365             


Asn Val Leu Ala Thr Gly Gly Gly Thr Ser Asp Arg His Ile Arg Ile 
    370                 375                 380                 


Trp Asn Val Cys Ser Gly Ala Cys Leu Ser Ala Val Asp Ala His Ser 
385                 390                 395                 400 


Gln Val Cys Ser Ile Leu Trp Ser Pro His Tyr Lys Glu Leu Ile Ser 
                405                 410                 415     


Gly His Gly Phe Ala Gln Asn Gln Leu Val Ile Trp Lys Tyr Pro Thr 
            420                 425                 430         


Met Ala Lys Val Ala Glu Leu Lys Gly His Thr Ser Arg Val Leu Ser 
        435                 440                 445             


Leu Thr Met Ser Pro Asp Gly Ala Thr Val Ala Ser Ala Ala Ala Asp 
    450                 455                 460                 


Glu Thr Leu Arg Leu Trp Arg Cys Phe Glu Leu Asp Pro Ala Arg Arg 
465                 470                 475                 480 


Arg Glu Arg Glu Lys Ala Ser Ala Ala Lys Ser Ser Leu Ile His Gln 
                485                 490                 495     


Gly Ile Arg 
            


<210> 11
<211> 5478
<212> DNA
<213> Homo sapiens

<400> 11
gcccaccggg cgagcttcta gtcggcgatt gaaggatgcg agtgctcctt aagggcctcc       60

gccccgtgag ttcggttgtg actaggaagg agctagtgga ctagagccag ggtaagggga      120

tctgctagaa gttggtcttc cgccaggact agagtttcct cgcggtaaca gcctccgtgg      180

cctccggagg accatgtcat tagactttgg cagtgtggca ctaccagtgc aaaatgaaga      240

tgaagagtat gacgaagagg actatgaaag agagaaagag ttgcagcagt tactcacaga      300

ccttccccat gacatgctgg atgacgacct ctcctctcca gagctccagt attcggactg      360

cagcgaggat ggcacagacg gacaaccaca tcatcctgag caattggaga tgagctggaa      420

tgagcaaatg ctgcccaaat ctcaaagtgt aaatggctat aatgaaattc agagtttata      480

tgctggagaa aaatgtggta atgtctggga agaaaataga agtaaaactg aagaccgaca      540

tcctgtgtac catcctgaag aaggtggaga tgaaggtgga agtggttata gtcctccaag      600

taaatgtgaa cagactgatt tatatcacct tcctgaaaac tttaggccat ataccaatgg      660

tcagaagcag gaatttaata accaagcaac caatgtaatt aaattttcag atcctcaatg      720

gaaccatttt cagggtccca gttgtcaagg tttggaaccg tataataaag tgacatataa      780

accttatcag tcttctgccc agaataatgg ctcaccagcc caggagataa caggaagtga      840

cacattcgaa ggcctgcaac aacaattttt aggagctaat gagaactctg cagaaaatat      900

gcagattatt caacttcagg ttcttaacaa agcaaaagag agacaactgg agaacttaat      960

tgaaaagtta aatgaaagtg aacgtcaaat tcgatatctg aatcaccagc ttgtaataat     1020

aaaagatgaa aaggatggtt tgactctcag ccttcgagaa tcacagaaac tctttcagaa     1080

tggaaaagaa agagagatac agcttgaagc tcaaataaaa gcactggaga ctcagataca     1140

agcattaaaa gtcaatgaag aacagatgat caagaagtcc agaacaactg aaatggctct     1200

ggaaagcttg aagcagcagc tggtggacct tcatcattct gaatcacttc aacgagctag     1260

agaacagcat gagagcattg ttatgggcct cacaaagaag tacgaagagc aagtattgtc     1320

cttacaaaag aatttggatg ccacagtcac cgcacttaaa gaacaggaag acatttgctc     1380

tcgtctgaaa gatcacgtga aacaactgga aaggaatcaa gaagcaatca agttagaaaa     1440

gactgagatc attaataagt tgacaagaag tctagaggag agtcaaaagc agtgtgccca     1500

cttgttgcag tccgggtcag tacaagaggt ggctcagcta cagttccagc tgcagcaagc     1560

acagaaggca catgctatga gtgcaaacat gaacaaggct ttgcaagaag aattaacaga     1620

actaaaagat gaaatttctc tctatgaatc tgctgcaaaa ctaggaatac atccaagtga     1680

ctcagaagga gaattaaata tagaactcac tgaatcgtat gtggatttgg gtattaaaaa     1740

ggtcaactgg aaaaaatcca aagttaccag cattgtacaa gaagaagacc caaatgaaga     1800

gctttcaaaa gatgagttca ttctgaagtt aaaggcagaa gtacagcgtt tgctgggtag     1860

caactcaatg aagcgtcatc tggtgtctca gttacaaaat gacctcaaag actgtcataa     1920

gaaaattgaa gatctccacc aagtgaagaa ggatgaaaaa agcattgagg ttgagactaa     1980

aacagatacc tcagaaaaac caaagaatca attatggcct gagtcttcta cttctgatgt     2040

tgtcagagat gatattctgc tgcttaaaaa tgaaattcaa gttttacaac aacaaaatca     2100

ggaacttaaa gaaactgaag gaaaactgag aaatacaaat caagacttat gtaatcaaat     2160

gagacaaatg gtacaagatt ttgaccatga caaacaagaa gctgtggata ggtgtgaaag     2220

gacttatcag cagcaccatg aagccatgaa aactcaaata cgtgaaagcc tattagcaaa     2280

gcatgctttg gagaagcagc agctctttga ggcttatgag agaactcatt tgcaactgag     2340

gtctgagttg gataagttga ataaggaggt gactgctgtg caggaatgtt acctagaagt     2400

gtgcagagag aaggataatc tagaattgac tctcaggaag accactgaaa aggagcaaca     2460

gactcaggag aagatcaaag aaaaactcat tcaacagctt gaaaaggagt ggcagtctaa     2520

gctggatcaa actataaagg caatgaaaaa gaagacctta gattgtggca gccaaactga     2580

ccaagtaacc accagtgatg ttatttccaa gaaagagatg gcaattatga tagaagagca     2640

gaagtgcaca atccagcaaa acttagaaca agagaaggac atagccatca agggggctat     2700

gaagaaactc gaaattgaat tggaactcaa acattgtgaa aatattacca aacaggtaga     2760

aatagctgtg caaaatgctc atcagcgatg gctgggagaa ctaccagagc tggcagagta     2820

tcaagcactt gtgaaggcag aacagaaaaa gtgggaagaa cagcatgagg tctctgtgaa     2880

caaaaggata tcatttgctg tttctgaagc taaagagaaa tggaagagtg agcttgaaaa     2940

tatgaggaaa aatatacttc ctggaaagga attggaagag aagattcatt ctcttcagaa     3000

ggaacttgag ttaaagaacg aagaagtccc tgtggtcatc agggctgagt tagctaaggc     3060

tcggagtgaa tggaacaaag aaaagcaaga agaaatccac agaatccaag aacaaaatga     3120

gcaagattac cggcaatttt tagatgatca ccgaaataaa attaatgagg tgcttgcggc     3180

agctaaagaa gactttatga aacaaaaaac tgaactactt cttcagaagg agacagaatt     3240

acaaacttgt ctagaccaga gtcgtagaga atggactatg caggaagcca agcggatcca     3300

actggaaatc tatcagtatg aggaagacat cctgactgta cttggggttc ttttaagtga     3360

tacccaaaag gagcacatca gtgattctga ggacaagcag cttttggaaa tcatgtcgac     3420

ttgttcttca aaatggatgt ctgtgcaata ttttgaaaaa ctaaagggct gcatacagaa     3480

agcatttcaa gatacacttc ctctgcttgt agaaaacgct gacccagaat ggaaaaagag     3540

aaatatggcc gagctctcta aggattctgc cagccagggc actggccaag gagaccctgg     3600

acctgctgct ggacaccatg ctcagccctt ggccttacaa gcaacagaag cagaagctga     3660

agagaataat aaagttgttg aagaattaat agaagaaaac aacgacatga agaataaatt     3720

ggaagaattg caaacacttt gtaaaacacc accaaggtca ttgtcagcag gggccattga     3780

aaatgcttgc ctgccatgca gtgggggagc cttggaagaa cttcgtgggc agtacattaa     3840

agctgtaaaa aaaattaaat gtgacatgct tcgttatatt caggagagta aggaacgagc     3900

tgcagaaatg gtaaaagcag aggtactgcg agaacgtcaa gaaaccgccc gaaagatgcg     3960

caaatattat ttgatttgcc tccaacagat tttgcaggat gatggaaaag aaggggctga     4020

gaaaaagatt atgaatgctg ctagcaaact tgctacaatg gcaaaattac tggaaacacc     4080

tatttctagt aagtcccaaa gcaaaactac acagtcagca ctgcccctaa cttcagagat     4140

gctgattgca gttaaaaaat caaaaagaaa tgatgtgaat cagaaaatac catgttgtat     4200

tgaaagcaaa tcaaatagtg taaacaccat caccagaact ctgtgcgaac aagctcccaa     4260

gaggagggca gcttgtaact tacaaaggct gttagagaac tcagagcatc agagcataaa     4320

gcatgtggga tccaaagaga cacatttgga attccagttt ggggatggta gttgcaagca     4380

cctaaacagt ttgccaagga atgtttctcc tgagtttgtt ccttgtgaag gtgaaggagg     4440

ctttggtttg cacaagaaga aagacctact cagtgataat ggttctgaat cacttccgca     4500

ttcagctgca tacccctttc ttggaacctt aggaaataaa ccctcaccta gatgtacccc     4560

tggtccttct gaatcaggat gcatgcatat aacctttcgc gattctaatg aaagacttgg     4620

tttaaaagta tataaatgca atccactaat ggaaagtgaa aatgctgcat ctgagaaaag     4680

tcaaggtttg gatgttcagg aacctccagt aaaagatgga ggggacctta gtgactgctt     4740

gggctggcct tccagcagtg caaccttatc ctttgacagt cgtgaagcat catttgtaca     4800

tggtaggcca caaggaactt tggaaatacc aagtgaatct gttaaatcca aacagttttc     4860

accatccggt tatctttcag atacagagga aagtaatatg atttgtcaaa caatgaaatg     4920

tcagcgttat caaactccat acctgtcaga agaaaccacg tatttggagc caggaaagat     4980

cagtgtgaat tgtggacacc catctcgtca taaggctgat agattaaagt cagatttcaa     5040

aaaactgagc agtacattac catcttcagt gtgtcagcag ccttcaagaa aattaattgt     5100

tccgctatct agccaacaag atagtggctt tgatagccca tttgttaatc tagactaatt     5160

atggtacagt atttaagaag aatcattaat atattaacaa aaatggaagg gaagacctca     5220

tactgaaaaa aattgtgagc cctgcctctt ttgagatgtt ttaataacat ctgttatata     5280

agtaaagcat tcttctaaaa ttgcttgaga tatttatgtt gccttaatat tccaaaggcc     5340

tgatggtgta tgtataatct gcttttgtgt ggtgcttatt tttggtttct aaaccatcta     5400

tttttatact tataaattga ctcactctgc agtgttaact tatttaaata aacttgcata     5460

tggtctgtaa aaaaaaaa                                                   5478


<210> 12
<211> 1654
<212> PRT
<213> Homo sapiens

<400> 12
Met Ser Leu Asp Phe Gly Ser Val Ala Leu Pro Val Gln Asn Glu Asp 
1               5                   10                  15      


Glu Glu Tyr Asp Glu Glu Asp Tyr Glu Arg Glu Lys Glu Leu Gln Gln 
            20                  25                  30          


Leu Leu Thr Asp Leu Pro His Asp Met Leu Asp Asp Asp Leu Ser Ser 
        35                  40                  45              


Pro Glu Leu Gln Tyr Ser Asp Cys Ser Glu Asp Gly Thr Asp Gly Gln 
    50                  55                  60                  


Pro His His Pro Glu Gln Leu Glu Met Ser Trp Asn Glu Gln Met Leu 
65                  70                  75                  80  


Pro Lys Ser Gln Ser Val Asn Gly Tyr Asn Glu Ile Gln Ser Leu Tyr 
                85                  90                  95      


Ala Gly Glu Lys Cys Gly Asn Val Trp Glu Glu Asn Arg Ser Lys Thr 
            100                 105                 110         


Glu Asp Arg His Pro Val Tyr His Pro Glu Glu Gly Gly Asp Glu Gly 
        115                 120                 125             


Gly Ser Gly Tyr Ser Pro Pro Ser Lys Cys Glu Gln Thr Asp Leu Tyr 
    130                 135                 140                 


His Leu Pro Glu Asn Phe Arg Pro Tyr Thr Asn Gly Gln Lys Gln Glu 
145                 150                 155                 160 


Phe Asn Asn Gln Ala Thr Asn Val Ile Lys Phe Ser Asp Pro Gln Trp 
                165                 170                 175     


Asn His Phe Gln Gly Pro Ser Cys Gln Gly Leu Glu Pro Tyr Asn Lys 
            180                 185                 190         


Val Thr Tyr Lys Pro Tyr Gln Ser Ser Ala Gln Asn Asn Gly Ser Pro 
        195                 200                 205             


Ala Gln Glu Ile Thr Gly Ser Asp Thr Phe Glu Gly Leu Gln Gln Gln 
    210                 215                 220                 


Phe Leu Gly Ala Asn Glu Asn Ser Ala Glu Asn Met Gln Ile Ile Gln 
225                 230                 235                 240 


Leu Gln Val Leu Asn Lys Ala Lys Glu Arg Gln Leu Glu Asn Leu Ile 
                245                 250                 255     


Glu Lys Leu Asn Glu Ser Glu Arg Gln Ile Arg Tyr Leu Asn His Gln 
            260                 265                 270         


Leu Val Ile Ile Lys Asp Glu Lys Asp Gly Leu Thr Leu Ser Leu Arg 
        275                 280                 285             


Glu Ser Gln Lys Leu Phe Gln Asn Gly Lys Glu Arg Glu Ile Gln Leu 
    290                 295                 300                 


Glu Ala Gln Ile Lys Ala Leu Glu Thr Gln Ile Gln Ala Leu Lys Val 
305                 310                 315                 320 


Asn Glu Glu Gln Met Ile Lys Lys Ser Arg Thr Thr Glu Met Ala Leu 
                325                 330                 335     


Glu Ser Leu Lys Gln Gln Leu Val Asp Leu His His Ser Glu Ser Leu 
            340                 345                 350         


Gln Arg Ala Arg Glu Gln His Glu Ser Ile Val Met Gly Leu Thr Lys 
        355                 360                 365             


Lys Tyr Glu Glu Gln Val Leu Ser Leu Gln Lys Asn Leu Asp Ala Thr 
    370                 375                 380                 


Val Thr Ala Leu Lys Glu Gln Glu Asp Ile Cys Ser Arg Leu Lys Asp 
385                 390                 395                 400 


His Val Lys Gln Leu Glu Arg Asn Gln Glu Ala Ile Lys Leu Glu Lys 
                405                 410                 415     


Thr Glu Ile Ile Asn Lys Leu Thr Arg Ser Leu Glu Glu Ser Gln Lys 
            420                 425                 430         


Gln Cys Ala His Leu Leu Gln Ser Gly Ser Val Gln Glu Val Ala Gln 
        435                 440                 445             


Leu Gln Phe Gln Leu Gln Gln Ala Gln Lys Ala His Ala Met Ser Ala 
    450                 455                 460                 


Asn Met Asn Lys Ala Leu Gln Glu Glu Leu Thr Glu Leu Lys Asp Glu 
465                 470                 475                 480 


Ile Ser Leu Tyr Glu Ser Ala Ala Lys Leu Gly Ile His Pro Ser Asp 
                485                 490                 495     


Ser Glu Gly Glu Leu Asn Ile Glu Leu Thr Glu Ser Tyr Val Asp Leu 
            500                 505                 510         


Gly Ile Lys Lys Val Asn Trp Lys Lys Ser Lys Val Thr Ser Ile Val 
        515                 520                 525             


Gln Glu Glu Asp Pro Asn Glu Glu Leu Ser Lys Asp Glu Phe Ile Leu 
    530                 535                 540                 


Lys Leu Lys Ala Glu Val Gln Arg Leu Leu Gly Ser Asn Ser Met Lys 
545                 550                 555                 560 


Arg His Leu Val Ser Gln Leu Gln Asn Asp Leu Lys Asp Cys His Lys 
                565                 570                 575     


Lys Ile Glu Asp Leu His Gln Val Lys Lys Asp Glu Lys Ser Ile Glu 
            580                 585                 590         


Val Glu Thr Lys Thr Asp Thr Ser Glu Lys Pro Lys Asn Gln Leu Trp 
        595                 600                 605             


Pro Glu Ser Ser Thr Ser Asp Val Val Arg Asp Asp Ile Leu Leu Leu 
    610                 615                 620                 


Lys Asn Glu Ile Gln Val Leu Gln Gln Gln Asn Gln Glu Leu Lys Glu 
625                 630                 635                 640 


Thr Glu Gly Lys Leu Arg Asn Thr Asn Gln Asp Leu Cys Asn Gln Met 
                645                 650                 655     


Arg Gln Met Val Gln Asp Phe Asp His Asp Lys Gln Glu Ala Val Asp 
            660                 665                 670         


Arg Cys Glu Arg Thr Tyr Gln Gln His His Glu Ala Met Lys Thr Gln 
        675                 680                 685             


Ile Arg Glu Ser Leu Leu Ala Lys His Ala Leu Glu Lys Gln Gln Leu 
    690                 695                 700                 


Phe Glu Ala Tyr Glu Arg Thr His Leu Gln Leu Arg Ser Glu Leu Asp 
705                 710                 715                 720 


Lys Leu Asn Lys Glu Val Thr Ala Val Gln Glu Cys Tyr Leu Glu Val 
                725                 730                 735     


Cys Arg Glu Lys Asp Asn Leu Glu Leu Thr Leu Arg Lys Thr Thr Glu 
            740                 745                 750         


Lys Glu Gln Gln Thr Gln Glu Lys Ile Lys Glu Lys Leu Ile Gln Gln 
        755                 760                 765             


Leu Glu Lys Glu Trp Gln Ser Lys Leu Asp Gln Thr Ile Lys Ala Met 
    770                 775                 780                 


Lys Lys Lys Thr Leu Asp Cys Gly Ser Gln Thr Asp Gln Val Thr Thr 
785                 790                 795                 800 


Ser Asp Val Ile Ser Lys Lys Glu Met Ala Ile Met Ile Glu Glu Gln 
                805                 810                 815     


Lys Cys Thr Ile Gln Gln Asn Leu Glu Gln Glu Lys Asp Ile Ala Ile 
            820                 825                 830         


Lys Gly Ala Met Lys Lys Leu Glu Ile Glu Leu Glu Leu Lys His Cys 
        835                 840                 845             


Glu Asn Ile Thr Lys Gln Val Glu Ile Ala Val Gln Asn Ala His Gln 
    850                 855                 860                 


Arg Trp Leu Gly Glu Leu Pro Glu Leu Ala Glu Tyr Gln Ala Leu Val 
865                 870                 875                 880 


Lys Ala Glu Gln Lys Lys Trp Glu Glu Gln His Glu Val Ser Val Asn 
                885                 890                 895     


Lys Arg Ile Ser Phe Ala Val Ser Glu Ala Lys Glu Lys Trp Lys Ser 
            900                 905                 910         


Glu Leu Glu Asn Met Arg Lys Asn Ile Leu Pro Gly Lys Glu Leu Glu 
        915                 920                 925             


Glu Lys Ile His Ser Leu Gln Lys Glu Leu Glu Leu Lys Asn Glu Glu 
    930                 935                 940                 


Val Pro Val Val Ile Arg Ala Glu Leu Ala Lys Ala Arg Ser Glu Trp 
945                 950                 955                 960 


Asn Lys Glu Lys Gln Glu Glu Ile His Arg Ile Gln Glu Gln Asn Glu 
                965                 970                 975     


Gln Asp Tyr Arg Gln Phe Leu Asp Asp His Arg Asn Lys Ile Asn Glu 
            980                 985                 990         


Val Leu Ala Ala Ala Lys Glu Asp  Phe Met Lys Gln Lys  Thr Glu Leu 
        995                 1000                 1005             


Leu Leu  Gln Lys Glu Thr Glu  Leu Gln Thr Cys Leu  Asp Gln Ser 
    1010                 1015                 1020             


Arg Arg  Glu Trp Thr Met Gln  Glu Ala Lys Arg Ile  Gln Leu Glu 
    1025                 1030                 1035             


Ile Tyr  Gln Tyr Glu Glu Asp  Ile Leu Thr Val Leu  Gly Val Leu 
    1040                 1045                 1050             


Leu Ser  Asp Thr Gln Lys Glu  His Ile Ser Asp Ser  Glu Asp Lys 
    1055                 1060                 1065             


Gln Leu  Leu Glu Ile Met Ser  Thr Cys Ser Ser Lys  Trp Met Ser 
    1070                 1075                 1080             


Val Gln  Tyr Phe Glu Lys Leu  Lys Gly Cys Ile Gln  Lys Ala Phe 
    1085                 1090                 1095             


Gln Asp  Thr Leu Pro Leu Leu  Val Glu Asn Ala Asp  Pro Glu Trp 
    1100                 1105                 1110             


Lys Lys  Arg Asn Met Ala Glu  Leu Ser Lys Asp Ser  Ala Ser Gln 
    1115                 1120                 1125             


Gly Thr  Gly Gln Gly Asp Pro  Gly Pro Ala Ala Gly  His His Ala 
    1130                 1135                 1140             


Gln Pro  Leu Ala Leu Gln Ala  Thr Glu Ala Glu Ala  Glu Glu Asn 
    1145                 1150                 1155             


Asn Lys  Val Val Glu Glu Leu  Ile Glu Glu Asn Asn  Asp Met Lys 
    1160                 1165                 1170             


Asn Lys  Leu Glu Glu Leu Gln  Thr Leu Cys Lys Thr  Pro Pro Arg 
    1175                 1180                 1185             


Ser Leu  Ser Ala Gly Ala Ile  Glu Asn Ala Cys Leu  Pro Cys Ser 
    1190                 1195                 1200             


Gly Gly  Ala Leu Glu Glu Leu  Arg Gly Gln Tyr Ile  Lys Ala Val 
    1205                 1210                 1215             


Lys Lys  Ile Lys Cys Asp Met  Leu Arg Tyr Ile Gln  Glu Ser Lys 
    1220                 1225                 1230             


Glu Arg  Ala Ala Glu Met Val  Lys Ala Glu Val Leu  Arg Glu Arg 
    1235                 1240                 1245             


Gln Glu  Thr Ala Arg Lys Met  Arg Lys Tyr Tyr Leu  Ile Cys Leu 
    1250                 1255                 1260             


Gln Gln  Ile Leu Gln Asp Asp  Gly Lys Glu Gly Ala  Glu Lys Lys 
    1265                 1270                 1275             


Ile Met  Asn Ala Ala Ser Lys  Leu Ala Thr Met Ala  Lys Leu Leu 
    1280                 1285                 1290             


Glu Thr  Pro Ile Ser Ser Lys  Ser Gln Ser Lys Thr  Thr Gln Ser 
    1295                 1300                 1305             


Ala Leu  Pro Leu Thr Ser Glu  Met Leu Ile Ala Val  Lys Lys Ser 
    1310                 1315                 1320             


Lys Arg  Asn Asp Val Asn Gln  Lys Ile Pro Cys Cys  Ile Glu Ser 
    1325                 1330                 1335             


Lys Ser  Asn Ser Val Asn Thr  Ile Thr Arg Thr Leu  Cys Glu Gln 
    1340                 1345                 1350             


Ala Pro  Lys Arg Arg Ala Ala  Cys Asn Leu Gln Arg  Leu Leu Glu 
    1355                 1360                 1365             


Asn Ser  Glu His Gln Ser Ile  Lys His Val Gly Ser  Lys Glu Thr 
    1370                 1375                 1380             


His Leu  Glu Phe Gln Phe Gly  Asp Gly Ser Cys Lys  His Leu Asn 
    1385                 1390                 1395             


Ser Leu  Pro Arg Asn Val Ser  Pro Glu Phe Val Pro  Cys Glu Gly 
    1400                 1405                 1410             


Glu Gly  Gly Phe Gly Leu His  Lys Lys Lys Asp Leu  Leu Ser Asp 
    1415                 1420                 1425             


Asn Gly  Ser Glu Ser Leu Pro  His Ser Ala Ala Tyr  Pro Phe Leu 
    1430                 1435                 1440             


Gly Thr  Leu Gly Asn Lys Pro  Ser Pro Arg Cys Thr  Pro Gly Pro 
    1445                 1450                 1455             


Ser Glu  Ser Gly Cys Met His  Ile Thr Phe Arg Asp  Ser Asn Glu 
    1460                 1465                 1470             


Arg Leu  Gly Leu Lys Val Tyr  Lys Cys Asn Pro Leu  Met Glu Ser 
    1475                 1480                 1485             


Glu Asn  Ala Ala Ser Glu Lys  Ser Gln Gly Leu Asp  Val Gln Glu 
    1490                 1495                 1500             


Pro Pro  Val Lys Asp Gly Gly  Asp Leu Ser Asp Cys  Leu Gly Trp 
    1505                 1510                 1515             


Pro Ser  Ser Ser Ala Thr Leu  Ser Phe Asp Ser Arg  Glu Ala Ser 
    1520                 1525                 1530             


Phe Val  His Gly Arg Pro Gln  Gly Thr Leu Glu Ile  Pro Ser Glu 
    1535                 1540                 1545             


Ser Val  Lys Ser Lys Gln Phe  Ser Pro Ser Gly Tyr  Leu Ser Asp 
    1550                 1555                 1560             


Thr Glu  Glu Ser Asn Met Ile  Cys Gln Thr Met Lys  Cys Gln Arg 
    1565                 1570                 1575             


Tyr Gln  Thr Pro Tyr Leu Ser  Glu Glu Thr Thr Tyr  Leu Glu Pro 
    1580                 1585                 1590             


Gly Lys  Ile Ser Val Asn Cys  Gly His Pro Ser Arg  His Lys Ala 
    1595                 1600                 1605             


Asp Arg  Leu Lys Ser Asp Phe  Lys Lys Leu Ser Ser  Thr Leu Pro 
    1610                 1615                 1620             


Ser Ser  Val Cys Gln Gln Pro  Ser Arg Lys Leu Ile  Val Pro Leu 
    1625                 1630                 1635             


Ser Ser  Gln Gln Asp Ser Gly  Phe Asp Ser Pro Phe  Val Asn Leu 
    1640                 1645                 1650             


Asp 
    


<210> 13
<211> 1260
<212> DNA
<213> Homo sapiens

<400> 13
ggccggcggg aagactccgt tacccagcga gcgaggcggc ggcgcagggc cagcggactc       60

catttcccgt cggctcgcgg tgggagcgcc ggaagcccgc cccacccctc attgtgcggc      120

tcctactaaa cggaaggggc cgggagaggc cgcgttcagt cgggtcccgg cagcggctgc      180

agcgctctcg tcttctgcgg ctctcggtgc cctctccttt tcgtttccgg aaacatggcc      240

tccggtgtgg ctgtctctga tggtgtcatc aaggtgttca acgacatgaa ggtgcgtaag      300

tcttcaacgc cagaggaggt gaagaagcgc aagaaggcgg tgctcttctg cctgagtgag      360

gacaagaaga acatcatcct ggaggagggc aaggagatcc tggtgggcga tgtgggccag      420

actgtcgacg acccctacgc cacctttgtc aagatgctgc cagataagga ctgccgctat      480

gccctctatg atgcaaccta tgagaccaag gagagcaaga aggaggatct ggtgtttatc      540

ttctgggccc ccgagtctgc gccccttaag agcaaaatga tttatgccag ctccaaggac      600

gccatcaaga agaagctgac agggatcaag catgaattgc aagcaaactg ctacgaggag      660

gtcaaggacc gctgcaccct ggcagagaag ctggggggca gtgccgtcat ctccctggag      720

ggcaagcctt tgtgagcccc ttctggcccc ctgcctggag catctggcag ccccacacct      780

gcccttgggg gttgcaggct gcccccttcc tgccagaccg gaggggctgg ggggatccca      840

gcagggggag ggcaatccct tcaccccagt tgccaaacag accccccacc ccctggattt      900

tccttctccc tccatccctt gacggttctg gccttcccaa actgcttttg atcttttgat      960

tcctcttggg ctgaagcaga ccaagttccc cccaggcacc ccagttgtgg gggagcctgt     1020

atttttttta acaacatccc cattccccac ctggtcctcc cccttcccat gctgccaact     1080

tctaaccgca atagtgactc tgtgcttgtc tgtttagttc tgtgtataaa tggaatgttg     1140

tggagatgac ccctccctgt gccggctggt tcctctccct tttcccctgg tcacggctac     1200

tcatggaagc aggaccagta agggaccttc gattaaaaaa aaaaaagaca ataataaaaa     1260


<210> 14
<211> 166
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Ser Ser Thr Pro Glu Glu Val Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile 
        35                  40                  45              


Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Thr Val 
    50                  55                  60                  


Asp Asp Pro Tyr Ala Thr Phe Val Lys Met Leu Pro Asp Lys Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys 
                85                  90                  95      


Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu 
        115                 120                 125             


Thr Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys 
    130                 135                 140                 


Asp Arg Cys Thr Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser 
145                 150                 155                 160 


Leu Glu Gly Lys Pro Leu 
                165     


<210> 15
<211> 633
<212> DNA
<213> Homo sapiens

<400> 15
atgcgcgcaa gagagcggga agccgagctg ggcgagaagt aggggagggc ggtgctccgc       60

cgcggtggcg gttgctatcg cttcgcagaa cctactcagg cagccagctg agaagagttg      120

agggaaagtg ctgctgctgg gtctgcagac gcgatggata acgtgcagcc gaaaataaaa      180

catcgcccct tctgcttcag tgtgaaaggc cacgtgaaga tgctgcggct ggtgtttgca      240

cttgtgacag cagtatgctg tcttgccgac ggggccctta tttaccggaa gcttctgttc      300

aatcccagcg gtccttacca gaaaaagcct gtgcatgaaa aaaaagaagt tttgtaattt      360

tatattactt tttagtttga tactaagtat taaacatatt tctgtattct tccacatatt      420

ttctgcagtt attttaactc agtataggag ctagaggaag agatttccga agtctgcacc      480

ccgcgcagag cactactgta acttccaagg gagcgctggg agcagcggga tcgggttttc      540

cggcacccgg gcctgggtgg cagggaagaa tgtgccggga tccgcctcag ggatctttga      600

atctctttac tgcctggctg gccggcagct ccg                                   633


<210> 16
<211> 67
<212> PRT
<213> Homo sapiens

<400> 16
Met Asp Asn Val Gln Pro Lys Ile Lys His Arg Pro Phe Cys Phe Ser 
1               5                   10                  15      


Val Lys Gly His Val Lys Met Leu Arg Leu Val Phe Ala Leu Val Thr 
            20                  25                  30          


Ala Val Cys Cys Leu Ala Asp Gly Ala Leu Ile Tyr Arg Lys Leu Leu 
        35                  40                  45              


Phe Asn Pro Ser Gly Pro Tyr Gln Lys Lys Pro Val His Glu Lys Lys 
    50                  55                  60                  


Glu Val Leu 
65          


<210> 17
<211> 9169
<212> DNA
<213> Homo sapiens

<400> 17
gatgacgctg cggcttctgg tggccgcgct ctgcgccggg atcctggcag aggcgccccg       60

agtgcgagcc cagcacaggg agagagtgac ctgcacgcgc ctttacgccg ctgacattgt      120

gttcttactg gatggctcct catccattgg ccgcagcaat ttccgcgagg tccgcagctt      180

tctcgaaggg ctggtgctgc ctttctctgg agcagccagt gcacagggtg tgcgctttgc      240

cacagtgcag tacagcgatg acccacggac agagttcggc ctggatgcac ttggctctgg      300

gggtgatgtg atccgcgcca tccgtgagct tagctacaag gggggcaaca ctcgcacagg      360

ggctgcaatt ctccatgtgg ctgaccatgt cttcctgccc cagctggccc gacctggtgt      420

ccccaaggtc tgcatcctga tcacagacgg gaagtcccag gacctggtgg acacagctgc      480

ccaaaggctg aaggggcagg gggtcaagct atttgctgtg gggatcaaga atgctgaccc      540

tgaggagctg aagcgagttg cctcacagcc caccagtgac ttcttcttct tcgtcaatga      600

cttcagcatc ttgaggacac tactgcccct cgtttcccgg agagtgtgca cgactgctgg      660

tggcgtgcct gtgacccgac ctccggatga ctcgacctct gctccacgag acctggtgct      720

gtctgagcca agcagccaat ccttgagagt acagtggaca gcggccagtg gccctgtgac      780

tggctacaag gtccagtaca ctcctctgac ggggctggga cagccactgc cgagtgagcg      840

gcaggaggtg aacgtcccag ctggtgagac cagtgtgcgg ctgcggggtc tccggccact      900

gaccgagtac caagtgactg tgattgccct ctacgccaac agcatcgggg aggctgtgag      960

cgggacagct cggaccactg ccctagaagg gccggaactg accatccaga ataccacagc     1020

ccacagcctc ctggtggcct ggcggagtgt gccaggtgcc actggctacc gtgtgacatg     1080

gcgggtcctc agtggtgggc ccacacagca gcaggagctg ggccctgggc agggttcagt     1140

gttgctgcgt gacttggagc ctggcacgga ctatgaggtg accgtgagca ccctatttgg     1200

ccgcagtgtg gggcccgcca cttccctgat ggctcgcact gacgcttctg ttgagcagac     1260

cctgcgcccg gtcatcctgg gccccacatc catcctcctt tcctggaact tggtgcctga     1320

ggcccgtggc taccggttgg aatggcggcg tgagactggc ttggagccac cgcagaaggt     1380

ggtactgccc tctgatgtga cccgctacca gttggatggg ctgcagccgg gcactgagta     1440

ccgcctcaca ctctacactc tgctggaggg ccacgaggtg gccacccctg caaccgtggt     1500

tcccactgga ccagagctgc ctgtgagccc tgtaacagac ctgcaagcca ccgagctgcc     1560

cgggcagcgg gtgcgagtgt cctggagccc agtccctggt gccacccagt accgcatcat     1620

tgtgcgcagc acccaggggg ttgagcggac cctggtgctt cctgggagtc agacagcatt     1680

cgacttggat gacgttcagg ctgggcttag ctacactgtg cgggtgtctg ctcgagtggg     1740

tccccgtgag ggcagtgcca gtgtcctcac tgtccgccgg gagccggaaa ctccacttgc     1800

tgttccaggg ctgcgggttg tggtgtcaga tgcaacgcga gtgagggtgg cctggggacc     1860

cgtccctgga gccagtggat ttcggattag ctggagcaca ggcagtggtc cggagtccag     1920

ccagacactg cccccagact ctactgccac agacatcaca gggctgcagc ctggaaccac     1980

ctaccaggtg gctgtgtcgg tactgcgagg cagagaggag ggccctgctg cagtcatcgt     2040

ggctcgaacg gacccactgg gcccagtgag gacggtccat gtgactcagg ccagcagctc     2100

atctgtcacc attacctgga ccagggttcc tggcgccaca ggatacaggg tttcctggca     2160

ctcagcccac ggcccagaga aatcccagtt ggtttctggg gaggccacgg tggctgagct     2220

ggatggactg gagccagata ctgagtatac ggtgcatgtg agggcccatg tggctggcgt     2280

ggatgggccc cctgcctctg tggttgtgag gactgcccct gagcctgtgg gtcgtgtgtc     2340

gaggctgcag atcctcaatg cttccagcga cgttctacgg atcacctggg taggggtcac     2400

tggagccaca gcttacagac tggcctgggg ccggagtgaa ggcggcccca tgaggcacca     2460

gatactccca ggaaacacag actctgcaga gatccggggt ctcgaaggtg gagtcagcta     2520

ctcagtgcga gtgactgcac ttgtcgggga ccgcgagggc acacctgtct ccattgttgt     2580

cactacgccg cctgaggctc cgccagccct ggggacgctt cacgtggtgc agcgcgggga     2640

gcactcgctg aggctgcgct gggagccggt gcccagagcg cagggcttcc ttctgcactg     2700

gcaacctgag ggtggccagg aacagtcccg ggtcctgggg cccgagctca gcagctatca     2760

cctggacggg ctggagccag cgacacagta ccgcgtgagg ctgagtgtcc tagggccagc     2820

tggagaaggg ccctctgcag aggtgactgc gcgcactgag tcacctcgtg ttccaagcat     2880

tgaactacgt gtggtggaca cctcgatcga ctcggtgact ttggcctgga ctccagtgtc     2940

cagggcatcc agctacatcc tatcctggcg gccactcaga ggccctggcc aggaagtgcc     3000

tgggtccccg cagacacttc cagggatctc aagctcccag cgggtgacag ggctagagcc     3060

tggcgtctct tacatcttct ccctgacgcc tgtcctggat ggtgtgcggg gtcctgaggc     3120

atctgtcaca cagacgccag tgtgcccccg tggcctggcg gatgtggtgt tcctaccaca     3180

tgccactcaa gacaatgctc accgtgcgga ggctacgagg agggtcctgg agcgtctggt     3240

gttggcactt gggcctcttg ggccacaggc agttcaggtt ggcctgctgt cttacagtca     3300

tcggccctcc ccactgttcc cactgaatgg ctcccatgac cttggcatta tcttgcaaag     3360

gatccgtgac atgccctaca tggacccaag tgggaacaac ctgggcacag ccgtggtcac     3420

agctcacaga tacatgttgg caccagatgc tcctgggcgc cgccagcacg taccaggggt     3480

gatggttctg ctagtggatg aacccttgag aggtgacata ttcagcccca tccgtgaggc     3540

ccaggcttct gggcttaatg tggtgatgtt gggaatggct ggagcggacc cagagcagct     3600

gcgtcgcttg gcgccgggta tggactctgt ccagaccttc ttcgccgtgg atgatgggcc     3660

aagcctggac caggcagtca gtggtctggc cacagccctg tgtcaggcat ccttcactac     3720

tcagccccgg ccagagccct gcccagtgta ttgtccaaag ggccagaagg gggaacctgg     3780

agagatgggc ctgagaggac aagttgggcc tcctggcgac cctggcctcc cgggcaggac     3840

cggtgctccc ggcccccagg ggccccctgg aagtgccact gccaagggcg agaggggctt     3900

ccctggagca gatgggcgtc caggcagccc tggccgcgcc gggaatcctg ggacccctgg     3960

agcccctggc ctaaagggct ctccagggtt gcctggccct cgtggggacc cgggagagcg     4020

aggacctcga ggcccaaagg gggagccggg ggctcccgga caagtcatcg gaggtgaagg     4080

acctgggctt cctgggcgga aaggggaccc tggaccatcg ggcccccctg gacctcgtgg     4140

accactgggg gacccaggac cccgtggccc cccagggctt cctggaacag ccatgaaggg     4200

tgacaaaggc gatcgtgggg agcggggtcc ccctggacca ggtgaaggtg gcattgctcc     4260

tggggagcct gggctgccgg gtcttcccgg aagccctgga ccccaaggcc ccgttggccc     4320

ccctggaaag aaaggagaaa aaggtgactc tgaggatgga gctccaggcc tcccaggaca     4380

acctgggtct ccgggtgagc agggcccacg gggacctcct ggagctattg gccccaaagg     4440

tgaccggggc tttccagggc ccctgggtga ggctggagag aagggcgaac gtggaccccc     4500

aggcccagcg ggatcccggg ggctgccagg ggttgctgga cgtcctggag ccaagggtcc     4560

tgaagggcca ccaggaccca ctggccgcca aggagagaag ggggagcctg gtcgccctgg     4620

ggaccctgca gtggtgggac ctgctgttgc tggacccaaa ggagaaaagg gagatgtggg     4680

gcccgctggg cccagaggag ctaccggagt ccaaggggaa cggggcccac ccggcttggt     4740

tcttcctgga gaccctggcc ccaagggaga ccctggagac cggggtccca ttggccttac     4800

tggcagagca ggacccccag gtgactcagg gcctcctgga gagaagggag accctgggcg     4860

gcctggcccc ccaggacctg ttggcccccg aggacgagat ggtgaagttg gagagaaagg     4920

tgacgagggt cctccgggtg acccgggttt gcctggaaaa gcaggcgagc gtggccttcg     4980

gggggcacct ggagttcggg ggcctgtggg tgaaaaggga gaccagggag atcctggaga     5040

ggatggacga aatggcagcc ctggatcatc tggacccaag ggtgaccgtg gggagccggg     5100

tcccccagga cccccgggac ggctggtaga cacaggacct ggagccagag agaagggaga     5160

gcctggggac cgcggacaag agggtcctcg agggcccaag ggtgatcctg gcctccctgg     5220

agcccctggg gaaaggggca ttgaagggtt tcggggaccc ccaggcccac agggggaccc     5280

aggtgtccga ggcccagcag gagaaaaggg tgaccggggt ccccctgggc tggatggccg     5340

gagcggactg gatgggaaac caggagccgc tgggccctct gggccgaatg gtgctgcagg     5400

caaagctggg gacccaggga gagacgggct tccaggcctc cgtggagaac agggcctccc     5460

tggcccctct ggtccccctg gattaccggg aaagccaggc gaggatggca aacctggcct     5520

gaatggaaaa aacggagaac ctggggaccc tggagaagac gggaggaagg gagagaaagg     5580

agattcaggc gcctctggga gagaaggtcg tgatggcccc aagggtgagc gtggagctcc     5640

tggtatcctt ggaccccagg ggcctccagg cctcccaggg ccagtgggcc ctcctggcca     5700

gggttttcct ggtgtcccag gaggcacggg ccccaagggt gaccgtgggg agactggatc     5760

caaaggggag cagggcctcc ctggagagcg tggcctgcga ggagagcctg gaagtgtgcc     5820

gaatgtggat cggttgctgg aaactgctgg catcaaggca tctgccctgc gggagatcgt     5880

ggagacctgg gatgagagct ctggtagctt cctgcctgtg cccgaacggc gtcgaggccc     5940

caagggggac tcaggcgaac agggcccccc aggcaaggag ggccccatcg gctttcctgg     6000

agaacgcggg ctgaagggcg accgtggaga ccctggccct caggggccac ctggtctggc     6060

ccttggggag aggggccccc ccgggccttc cggccttgcc ggggagcctg gaaagcctgg     6120

tattcccggg ctcccaggca gggctggggg tgtgggagag gcaggaaggc caggagagag     6180

gggagaacgg ggagagaaag gagaacgtgg agaacagggc agagatggcc ctcctggact     6240

ccctggaacc cctgggcccc ccggaccccc tggccccaag gtgtctgtgg atgagccagg     6300

tcctggactc tctggagaac agggaccccc tggactcaag ggtgctaagg gggagccggg     6360

cagcaatggt gaccaaggtc ccaaaggaga caggggtgtg ccaggcatca aaggagaccg     6420

gggagagcct ggaccgaggg gtcaggacgg caacccgggt ctaccaggag agcgtggtat     6480

ggctgggcct gaagggaagc cgggtctgca gggtccaaga ggcccccctg gcccagtggg     6540

tggtcatgga gaccctggac cacctggtgc cccgggtctt gctggccctg caggacccca     6600

aggaccttct ggcctgaagg gggagcctgg agagacagga cctccaggac ggggcctgac     6660

tggacctact ggagctgtgg gacttcctgg accccccggc ccttcaggcc ttgtgggtcc     6720

acaggggtct ccaggtttgc ctggacaagt gggggagaca gggaagccgg gagccccagg     6780

tcgagatggt gccagtggaa aagatggaga cagagggagc cctggtgtgc cagggtcacc     6840

aggtctgcct ggccctgtcg gacctaaagg agaacctggc cccacggggg cccctggaca     6900

ggctgtggtc gggctccctg gagcaaaggg agagaaggga gcccctggag gccttgctgg     6960

agacctggtg ggtgagccgg gagccaaagg tgaccgagga ctgccagggc cgcgaggcga     7020

gaagggtgaa gctggccgtg caggggagcc cggagaccct ggggaagatg gtcagaaagg     7080

ggctccagga cccaaaggtt tcaagggtga cccaggagtc ggggtcccgg gctcccctgg     7140

gcctcctggc cctccaggtg tgaagggaga tctgggcctc cctggcctgc ccggtgctcc     7200

tggtgttgtt gggttcccgg gtcagacagg ccctcgagga gagatgggtc agccaggccc     7260

tagtggagag cggggtctgg caggcccccc agggagagaa ggaatcccag gacccctggg     7320

gccacctgga ccaccggggt cagtgggacc acctggggcc tctggactca aaggagacaa     7380

gggagaccct ggagtagggc tgcctgggcc ccgaggcgag cgtggggagc caggcatccg     7440

gggtgaagat ggccgccccg gccaggaggg accccgagga ctcacggggc cccctggcag     7500

caggggagag cgtggggaga agggtgatgt tgggagtgca ggactaaagg gtgacaaggg     7560

agactcagct gtgatcctgg ggcctccagg cccacggggt gccaaggggg acatgggtga     7620

acgagggcct cggggcttgg atggtgacaa aggacctcgg ggagacaatg gggaccctgg     7680

tgacaagggc agcaagggag agcctggtga caagggctca gccgggttgc caggactgcg     7740

tggactcctg ggaccccagg gtcaacctgg tgcagcaggg atccctggtg acccgggatc     7800

cccaggaaag gatggagtgc ctggtatccg aggagaaaaa ggagatgttg gcttcatggg     7860

tccccggggc ctcaagggtg aacggggagt gaagggagcc tgtggccttg atggagagaa     7920

gggagacaag ggagaagctg gtcccccagg ccgccccggg ctggcaggac acaaaggaga     7980

gatgggggag cctggtgtgc cgggccagtc gggggcccct ggcaaggagg gcctgatcgg     8040

tcccaagggt gaccgaggct ttgacgggca gccaggcccc aagggtgacc agggcgagaa     8100

aggggagcgg ggaaccccag gaattggggg cttcccaggc cccagtggaa atgatggctc     8160

tgctggtccc ccagggccac ctggcagtgt tggtcccaga ggccccgaag gacttcaggg     8220

ccagaagggt gagcgaggtc cccccggaga gagagtggtg ggggctcctg gggtccctgg     8280

agctcctggc gagagagggg agcaggggcg gccagggcct gccggtcctc gaggcgagaa     8340

gggagaagct gcactgacgg aggatgacat ccggggcttt gtgcgccaag agatgagtca     8400

gcactgtgcc tgccagggcc agttcatcgc atctggatca cgacccctcc ctagttatgc     8460

tgcagacact gccggctccc agctccatgc tgtgcctgtg ctccgcgtct ctcatgcaga     8520

ggaggaagag cgggtacccc ctgaggatga tgagtactct gaatactccg agtattctgt     8580

ggaggagtac caggaccctg aagctccttg ggatagtgat gacccctgtt ccctgccact     8640

ggatgagggc tcctgcactg cctacaccct gcgctggtac catcgggctg tgacaggcag     8700

cacagaggcc tgtcaccctt ttgtctatgg tggctgtgga gggaatgcca accgttttgg     8760

gacccgtgag gcctgcgagc gccgctgccc accccgggtg gtccagagcc aggggacagg     8820

tactgcccag gactgaggcc cagataatga gctgagattc agcatcccct ggaggagtcg     8880

gggtctcagc agaaccccac tgtccctccc cttggtgcta gaggcttgtg tgcacgtgag     8940

cgtgcgtgtg cacgtccgtt atttcagtga cttggtcccg tgggtctagc cttcccccct     9000

gtggacaaac ccccattgtg gctcctgcca ccctggcaga tgactcactg tgggggggtg     9060

gctgtgggca gtgagcggat gtgactggcg tctgacccgc cccttgaccc aagcctgtga     9120

tgacatggtg ctgattctgg ggggcattaa agctgctgtt ttaaaaggc                 9169


<210> 18
<211> 2944
<212> PRT
<213> Homo sapiens

<400> 18
Met Thr Leu Arg Leu Leu Val Ala Ala Leu Cys Ala Gly Ile Leu Ala 
1               5                   10                  15      


Glu Ala Pro Arg Val Arg Ala Gln His Arg Glu Arg Val Thr Cys Thr 
            20                  25                  30          


Arg Leu Tyr Ala Ala Asp Ile Val Phe Leu Leu Asp Gly Ser Ser Ser 
        35                  40                  45              


Ile Gly Arg Ser Asn Phe Arg Glu Val Arg Ser Phe Leu Glu Gly Leu 
    50                  55                  60                  


Val Leu Pro Phe Ser Gly Ala Ala Ser Ala Gln Gly Val Arg Phe Ala 
65                  70                  75                  80  


Thr Val Gln Tyr Ser Asp Asp Pro Arg Thr Glu Phe Gly Leu Asp Ala 
                85                  90                  95      


Leu Gly Ser Gly Gly Asp Val Ile Arg Ala Ile Arg Glu Leu Ser Tyr 
            100                 105                 110         


Lys Gly Gly Asn Thr Arg Thr Gly Ala Ala Ile Leu His Val Ala Asp 
        115                 120                 125             


His Val Phe Leu Pro Gln Leu Ala Arg Pro Gly Val Pro Lys Val Cys 
    130                 135                 140                 


Ile Leu Ile Thr Asp Gly Lys Ser Gln Asp Leu Val Asp Thr Ala Ala 
145                 150                 155                 160 


Gln Arg Leu Lys Gly Gln Gly Val Lys Leu Phe Ala Val Gly Ile Lys 
                165                 170                 175     


Asn Ala Asp Pro Glu Glu Leu Lys Arg Val Ala Ser Gln Pro Thr Ser 
            180                 185                 190         


Asp Phe Phe Phe Phe Val Asn Asp Phe Ser Ile Leu Arg Thr Leu Leu 
        195                 200                 205             


Pro Leu Val Ser Arg Arg Val Cys Thr Thr Ala Gly Gly Val Pro Val 
    210                 215                 220                 


Thr Arg Pro Pro Asp Asp Ser Thr Ser Ala Pro Arg Asp Leu Val Leu 
225                 230                 235                 240 


Ser Glu Pro Ser Ser Gln Ser Leu Arg Val Gln Trp Thr Ala Ala Ser 
                245                 250                 255     


Gly Pro Val Thr Gly Tyr Lys Val Gln Tyr Thr Pro Leu Thr Gly Leu 
            260                 265                 270         


Gly Gln Pro Leu Pro Ser Glu Arg Gln Glu Val Asn Val Pro Ala Gly 
        275                 280                 285             


Glu Thr Ser Val Arg Leu Arg Gly Leu Arg Pro Leu Thr Glu Tyr Gln 
    290                 295                 300                 


Val Thr Val Ile Ala Leu Tyr Ala Asn Ser Ile Gly Glu Ala Val Ser 
305                 310                 315                 320 


Gly Thr Ala Arg Thr Thr Ala Leu Glu Gly Pro Glu Leu Thr Ile Gln 
                325                 330                 335     


Asn Thr Thr Ala His Ser Leu Leu Val Ala Trp Arg Ser Val Pro Gly 
            340                 345                 350         


Ala Thr Gly Tyr Arg Val Thr Trp Arg Val Leu Ser Gly Gly Pro Thr 
        355                 360                 365             


Gln Gln Gln Glu Leu Gly Pro Gly Gln Gly Ser Val Leu Leu Arg Asp 
    370                 375                 380                 


Leu Glu Pro Gly Thr Asp Tyr Glu Val Thr Val Ser Thr Leu Phe Gly 
385                 390                 395                 400 


Arg Ser Val Gly Pro Ala Thr Ser Leu Met Ala Arg Thr Asp Ala Ser 
                405                 410                 415     


Val Glu Gln Thr Leu Arg Pro Val Ile Leu Gly Pro Thr Ser Ile Leu 
            420                 425                 430         


Leu Ser Trp Asn Leu Val Pro Glu Ala Arg Gly Tyr Arg Leu Glu Trp 
        435                 440                 445             


Arg Arg Glu Thr Gly Leu Glu Pro Pro Gln Lys Val Val Leu Pro Ser 
    450                 455                 460                 


Asp Val Thr Arg Tyr Gln Leu Asp Gly Leu Gln Pro Gly Thr Glu Tyr 
465                 470                 475                 480 


Arg Leu Thr Leu Tyr Thr Leu Leu Glu Gly His Glu Val Ala Thr Pro 
                485                 490                 495     


Ala Thr Val Val Pro Thr Gly Pro Glu Leu Pro Val Ser Pro Val Thr 
            500                 505                 510         


Asp Leu Gln Ala Thr Glu Leu Pro Gly Gln Arg Val Arg Val Ser Trp 
        515                 520                 525             


Ser Pro Val Pro Gly Ala Thr Gln Tyr Arg Ile Ile Val Arg Ser Thr 
    530                 535                 540                 


Gln Gly Val Glu Arg Thr Leu Val Leu Pro Gly Ser Gln Thr Ala Phe 
545                 550                 555                 560 


Asp Leu Asp Asp Val Gln Ala Gly Leu Ser Tyr Thr Val Arg Val Ser 
                565                 570                 575     


Ala Arg Val Gly Pro Arg Glu Gly Ser Ala Ser Val Leu Thr Val Arg 
            580                 585                 590         


Arg Glu Pro Glu Thr Pro Leu Ala Val Pro Gly Leu Arg Val Val Val 
        595                 600                 605             


Ser Asp Ala Thr Arg Val Arg Val Ala Trp Gly Pro Val Pro Gly Ala 
    610                 615                 620                 


Ser Gly Phe Arg Ile Ser Trp Ser Thr Gly Ser Gly Pro Glu Ser Ser 
625                 630                 635                 640 


Gln Thr Leu Pro Pro Asp Ser Thr Ala Thr Asp Ile Thr Gly Leu Gln 
                645                 650                 655     


Pro Gly Thr Thr Tyr Gln Val Ala Val Ser Val Leu Arg Gly Arg Glu 
            660                 665                 670         


Glu Gly Pro Ala Ala Val Ile Val Ala Arg Thr Asp Pro Leu Gly Pro 
        675                 680                 685             


Val Arg Thr Val His Val Thr Gln Ala Ser Ser Ser Ser Val Thr Ile 
    690                 695                 700                 


Thr Trp Thr Arg Val Pro Gly Ala Thr Gly Tyr Arg Val Ser Trp His 
705                 710                 715                 720 


Ser Ala His Gly Pro Glu Lys Ser Gln Leu Val Ser Gly Glu Ala Thr 
                725                 730                 735     


Val Ala Glu Leu Asp Gly Leu Glu Pro Asp Thr Glu Tyr Thr Val His 
            740                 745                 750         


Val Arg Ala His Val Ala Gly Val Asp Gly Pro Pro Ala Ser Val Val 
        755                 760                 765             


Val Arg Thr Ala Pro Glu Pro Val Gly Arg Val Ser Arg Leu Gln Ile 
    770                 775                 780                 


Leu Asn Ala Ser Ser Asp Val Leu Arg Ile Thr Trp Val Gly Val Thr 
785                 790                 795                 800 


Gly Ala Thr Ala Tyr Arg Leu Ala Trp Gly Arg Ser Glu Gly Gly Pro 
                805                 810                 815     


Met Arg His Gln Ile Leu Pro Gly Asn Thr Asp Ser Ala Glu Ile Arg 
            820                 825                 830         


Gly Leu Glu Gly Gly Val Ser Tyr Ser Val Arg Val Thr Ala Leu Val 
        835                 840                 845             


Gly Asp Arg Glu Gly Thr Pro Val Ser Ile Val Val Thr Thr Pro Pro 
    850                 855                 860                 


Glu Ala Pro Pro Ala Leu Gly Thr Leu His Val Val Gln Arg Gly Glu 
865                 870                 875                 880 


His Ser Leu Arg Leu Arg Trp Glu Pro Val Pro Arg Ala Gln Gly Phe 
                885                 890                 895     


Leu Leu His Trp Gln Pro Glu Gly Gly Gln Glu Gln Ser Arg Val Leu 
            900                 905                 910         


Gly Pro Glu Leu Ser Ser Tyr His Leu Asp Gly Leu Glu Pro Ala Thr 
        915                 920                 925             


Gln Tyr Arg Val Arg Leu Ser Val Leu Gly Pro Ala Gly Glu Gly Pro 
    930                 935                 940                 


Ser Ala Glu Val Thr Ala Arg Thr Glu Ser Pro Arg Val Pro Ser Ile 
945                 950                 955                 960 


Glu Leu Arg Val Val Asp Thr Ser Ile Asp Ser Val Thr Leu Ala Trp 
                965                 970                 975     


Thr Pro Val Ser Arg Ala Ser Ser Tyr Ile Leu Ser Trp Arg Pro Leu 
            980                 985                 990         


Arg Gly Pro Gly Gln Glu Val Pro  Gly Ser Pro Gln Thr  Leu Pro Gly 
        995                 1000                 1005             


Ile Ser  Ser Ser Gln Arg Val  Thr Gly Leu Glu Pro  Gly Val Ser 
    1010                 1015                 1020             


Tyr Ile  Phe Ser Leu Thr Pro  Val Leu Asp Gly Val  Arg Gly Pro 
    1025                 1030                 1035             


Glu Ala  Ser Val Thr Gln Thr  Pro Val Cys Pro Arg  Gly Leu Ala 
    1040                 1045                 1050             


Asp Val  Val Phe Leu Pro His  Ala Thr Gln Asp Asn  Ala His Arg 
    1055                 1060                 1065             


Ala Glu  Ala Thr Arg Arg Val  Leu Glu Arg Leu Val  Leu Ala Leu 
    1070                 1075                 1080             


Gly Pro  Leu Gly Pro Gln Ala  Val Gln Val Gly Leu  Leu Ser Tyr 
    1085                 1090                 1095             


Ser His  Arg Pro Ser Pro Leu  Phe Pro Leu Asn Gly  Ser His Asp 
    1100                 1105                 1110             


Leu Gly  Ile Ile Leu Gln Arg  Ile Arg Asp Met Pro  Tyr Met Asp 
    1115                 1120                 1125             


Pro Ser  Gly Asn Asn Leu Gly  Thr Ala Val Val Thr  Ala His Arg 
    1130                 1135                 1140             


Tyr Met  Leu Ala Pro Asp Ala  Pro Gly Arg Arg Gln  His Val Pro 
    1145                 1150                 1155             


Gly Val  Met Val Leu Leu Val  Asp Glu Pro Leu Arg  Gly Asp Ile 
    1160                 1165                 1170             


Phe Ser  Pro Ile Arg Glu Ala  Gln Ala Ser Gly Leu  Asn Val Val 
    1175                 1180                 1185             


Met Leu  Gly Met Ala Gly Ala  Asp Pro Glu Gln Leu  Arg Arg Leu 
    1190                 1195                 1200             


Ala Pro  Gly Met Asp Ser Val  Gln Thr Phe Phe Ala  Val Asp Asp 
    1205                 1210                 1215             


Gly Pro  Ser Leu Asp Gln Ala  Val Ser Gly Leu Ala  Thr Ala Leu 
    1220                 1225                 1230             


Cys Gln  Ala Ser Phe Thr Thr  Gln Pro Arg Pro Glu  Pro Cys Pro 
    1235                 1240                 1245             


Val Tyr  Cys Pro Lys Gly Gln  Lys Gly Glu Pro Gly  Glu Met Gly 
    1250                 1255                 1260             


Leu Arg  Gly Gln Val Gly Pro  Pro Gly Asp Pro Gly  Leu Pro Gly 
    1265                 1270                 1275             


Arg Thr  Gly Ala Pro Gly Pro  Gln Gly Pro Pro Gly  Ser Ala Thr 
    1280                 1285                 1290             


Ala Lys  Gly Glu Arg Gly Phe  Pro Gly Ala Asp Gly  Arg Pro Gly 
    1295                 1300                 1305             


Ser Pro  Gly Arg Ala Gly Asn  Pro Gly Thr Pro Gly  Ala Pro Gly 
    1310                 1315                 1320             


Leu Lys  Gly Ser Pro Gly Leu  Pro Gly Pro Arg Gly  Asp Pro Gly 
    1325                 1330                 1335             


Glu Arg  Gly Pro Arg Gly Pro  Lys Gly Glu Pro Gly  Ala Pro Gly 
    1340                 1345                 1350             


Gln Val  Ile Gly Gly Glu Gly  Pro Gly Leu Pro Gly  Arg Lys Gly 
    1355                 1360                 1365             


Asp Pro  Gly Pro Ser Gly Pro  Pro Gly Pro Arg Gly  Pro Leu Gly 
    1370                 1375                 1380             


Asp Pro  Gly Pro Arg Gly Pro  Pro Gly Leu Pro Gly  Thr Ala Met 
    1385                 1390                 1395             


Lys Gly  Asp Lys Gly Asp Arg  Gly Glu Arg Gly Pro  Pro Gly Pro 
    1400                 1405                 1410             


Gly Glu  Gly Gly Ile Ala Pro  Gly Glu Pro Gly Leu  Pro Gly Leu 
    1415                 1420                 1425             


Pro Gly  Ser Pro Gly Pro Gln  Gly Pro Val Gly Pro  Pro Gly Lys 
    1430                 1435                 1440             


Lys Gly  Glu Lys Gly Asp Ser  Glu Asp Gly Ala Pro  Gly Leu Pro 
    1445                 1450                 1455             


Gly Gln  Pro Gly Ser Pro Gly  Glu Gln Gly Pro Arg  Gly Pro Pro 
    1460                 1465                 1470             


Gly Ala  Ile Gly Pro Lys Gly  Asp Arg Gly Phe Pro  Gly Pro Leu 
    1475                 1480                 1485             


Gly Glu  Ala Gly Glu Lys Gly  Glu Arg Gly Pro Pro  Gly Pro Ala 
    1490                 1495                 1500             


Gly Ser  Arg Gly Leu Pro Gly  Val Ala Gly Arg Pro  Gly Ala Lys 
    1505                 1510                 1515             


Gly Pro  Glu Gly Pro Pro Gly  Pro Thr Gly Arg Gln  Gly Glu Lys 
    1520                 1525                 1530             


Gly Glu  Pro Gly Arg Pro Gly  Asp Pro Ala Val Val  Gly Pro Ala 
    1535                 1540                 1545             


Val Ala  Gly Pro Lys Gly Glu  Lys Gly Asp Val Gly  Pro Ala Gly 
    1550                 1555                 1560             


Pro Arg  Gly Ala Thr Gly Val  Gln Gly Glu Arg Gly  Pro Pro Gly 
    1565                 1570                 1575             


Leu Val  Leu Pro Gly Asp Pro  Gly Pro Lys Gly Asp  Pro Gly Asp 
    1580                 1585                 1590             


Arg Gly  Pro Ile Gly Leu Thr  Gly Arg Ala Gly Pro  Pro Gly Asp 
    1595                 1600                 1605             


Ser Gly  Pro Pro Gly Glu Lys  Gly Asp Pro Gly Arg  Pro Gly Pro 
    1610                 1615                 1620             


Pro Gly  Pro Val Gly Pro Arg  Gly Arg Asp Gly Glu  Val Gly Glu 
    1625                 1630                 1635             


Lys Gly  Asp Glu Gly Pro Pro  Gly Asp Pro Gly Leu  Pro Gly Lys 
    1640                 1645                 1650             


Ala Gly  Glu Arg Gly Leu Arg  Gly Ala Pro Gly Val  Arg Gly Pro 
    1655                 1660                 1665             


Val Gly  Glu Lys Gly Asp Gln  Gly Asp Pro Gly Glu  Asp Gly Arg 
    1670                 1675                 1680             


Asn Gly  Ser Pro Gly Ser Ser  Gly Pro Lys Gly Asp  Arg Gly Glu 
    1685                 1690                 1695             


Pro Gly  Pro Pro Gly Pro Pro  Gly Arg Leu Val Asp  Thr Gly Pro 
    1700                 1705                 1710             


Gly Ala  Arg Glu Lys Gly Glu  Pro Gly Asp Arg Gly  Gln Glu Gly 
    1715                 1720                 1725             


Pro Arg  Gly Pro Lys Gly Asp  Pro Gly Leu Pro Gly  Ala Pro Gly 
    1730                 1735                 1740             


Glu Arg  Gly Ile Glu Gly Phe  Arg Gly Pro Pro Gly  Pro Gln Gly 
    1745                 1750                 1755             


Asp Pro  Gly Val Arg Gly Pro  Ala Gly Glu Lys Gly  Asp Arg Gly 
    1760                 1765                 1770             


Pro Pro  Gly Leu Asp Gly Arg  Ser Gly Leu Asp Gly  Lys Pro Gly 
    1775                 1780                 1785             


Ala Ala  Gly Pro Ser Gly Pro  Asn Gly Ala Ala Gly  Lys Ala Gly 
    1790                 1795                 1800             


Asp Pro  Gly Arg Asp Gly Leu  Pro Gly Leu Arg Gly  Glu Gln Gly 
    1805                 1810                 1815             


Leu Pro  Gly Pro Ser Gly Pro  Pro Gly Leu Pro Gly  Lys Pro Gly 
    1820                 1825                 1830             


Glu Asp  Gly Lys Pro Gly Leu  Asn Gly Lys Asn Gly  Glu Pro Gly 
    1835                 1840                 1845             


Asp Pro  Gly Glu Asp Gly Arg  Lys Gly Glu Lys Gly  Asp Ser Gly 
    1850                 1855                 1860             


Ala Ser  Gly Arg Glu Gly Arg  Asp Gly Pro Lys Gly  Glu Arg Gly 
    1865                 1870                 1875             


Ala Pro  Gly Ile Leu Gly Pro  Gln Gly Pro Pro Gly  Leu Pro Gly 
    1880                 1885                 1890             


Pro Val  Gly Pro Pro Gly Gln  Gly Phe Pro Gly Val  Pro Gly Gly 
    1895                 1900                 1905             


Thr Gly  Pro Lys Gly Asp Arg  Gly Glu Thr Gly Ser  Lys Gly Glu 
    1910                 1915                 1920             


Gln Gly  Leu Pro Gly Glu Arg  Gly Leu Arg Gly Glu  Pro Gly Ser 
    1925                 1930                 1935             


Val Pro  Asn Val Asp Arg Leu  Leu Glu Thr Ala Gly  Ile Lys Ala 
    1940                 1945                 1950             


Ser Ala  Leu Arg Glu Ile Val  Glu Thr Trp Asp Glu  Ser Ser Gly 
    1955                 1960                 1965             


Ser Phe  Leu Pro Val Pro Glu  Arg Arg Arg Gly Pro  Lys Gly Asp 
    1970                 1975                 1980             


Ser Gly  Glu Gln Gly Pro Pro  Gly Lys Glu Gly Pro  Ile Gly Phe 
    1985                 1990                 1995             


Pro Gly  Glu Arg Gly Leu Lys  Gly Asp Arg Gly Asp  Pro Gly Pro 
    2000                 2005                 2010             


Gln Gly  Pro Pro Gly Leu Ala  Leu Gly Glu Arg Gly  Pro Pro Gly 
    2015                 2020                 2025             


Pro Ser  Gly Leu Ala Gly Glu  Pro Gly Lys Pro Gly  Ile Pro Gly 
    2030                 2035                 2040             


Leu Pro  Gly Arg Ala Gly Gly  Val Gly Glu Ala Gly  Arg Pro Gly 
    2045                 2050                 2055             


Glu Arg  Gly Glu Arg Gly Glu  Lys Gly Glu Arg Gly  Glu Gln Gly 
    2060                 2065                 2070             


Arg Asp  Gly Pro Pro Gly Leu  Pro Gly Thr Pro Gly  Pro Pro Gly 
    2075                 2080                 2085             


Pro Pro  Gly Pro Lys Val Ser  Val Asp Glu Pro Gly  Pro Gly Leu 
    2090                 2095                 2100             


Ser Gly  Glu Gln Gly Pro Pro  Gly Leu Lys Gly Ala  Lys Gly Glu 
    2105                 2110                 2115             


Pro Gly  Ser Asn Gly Asp Gln  Gly Pro Lys Gly Asp  Arg Gly Val 
    2120                 2125                 2130             


Pro Gly  Ile Lys Gly Asp Arg  Gly Glu Pro Gly Pro  Arg Gly Gln 
    2135                 2140                 2145             


Asp Gly  Asn Pro Gly Leu Pro  Gly Glu Arg Gly Met  Ala Gly Pro 
    2150                 2155                 2160             


Glu Gly  Lys Pro Gly Leu Gln  Gly Pro Arg Gly Pro  Pro Gly Pro 
    2165                 2170                 2175             


Val Gly  Gly His Gly Asp Pro  Gly Pro Pro Gly Ala  Pro Gly Leu 
    2180                 2185                 2190             


Ala Gly  Pro Ala Gly Pro Gln  Gly Pro Ser Gly Leu  Lys Gly Glu 
    2195                 2200                 2205             


Pro Gly  Glu Thr Gly Pro Pro  Gly Arg Gly Leu Thr  Gly Pro Thr 
    2210                 2215                 2220             


Gly Ala  Val Gly Leu Pro Gly  Pro Pro Gly Pro Ser  Gly Leu Val 
    2225                 2230                 2235             


Gly Pro  Gln Gly Ser Pro Gly  Leu Pro Gly Gln Val  Gly Glu Thr 
    2240                 2245                 2250             


Gly Lys  Pro Gly Ala Pro Gly  Arg Asp Gly Ala Ser  Gly Lys Asp 
    2255                 2260                 2265             


Gly Asp  Arg Gly Ser Pro Gly  Val Pro Gly Ser Pro  Gly Leu Pro 
    2270                 2275                 2280             


Gly Pro  Val Gly Pro Lys Gly  Glu Pro Gly Pro Thr  Gly Ala Pro 
    2285                 2290                 2295             


Gly Gln  Ala Val Val Gly Leu  Pro Gly Ala Lys Gly  Glu Lys Gly 
    2300                 2305                 2310             


Ala Pro  Gly Gly Leu Ala Gly  Asp Leu Val Gly Glu  Pro Gly Ala 
    2315                 2320                 2325             


Lys Gly  Asp Arg Gly Leu Pro  Gly Pro Arg Gly Glu  Lys Gly Glu 
    2330                 2335                 2340             


Ala Gly  Arg Ala Gly Glu Pro  Gly Asp Pro Gly Glu  Asp Gly Gln 
    2345                 2350                 2355             


Lys Gly  Ala Pro Gly Pro Lys  Gly Phe Lys Gly Asp  Pro Gly Val 
    2360                 2365                 2370             


Gly Val  Pro Gly Ser Pro Gly  Pro Pro Gly Pro Pro  Gly Val Lys 
    2375                 2380                 2385             


Gly Asp  Leu Gly Leu Pro Gly  Leu Pro Gly Ala Pro  Gly Val Val 
    2390                 2395                 2400             


Gly Phe  Pro Gly Gln Thr Gly  Pro Arg Gly Glu Met  Gly Gln Pro 
    2405                 2410                 2415             


Gly Pro  Ser Gly Glu Arg Gly  Leu Ala Gly Pro Pro  Gly Arg Glu 
    2420                 2425                 2430             


Gly Ile  Pro Gly Pro Leu Gly  Pro Pro Gly Pro Pro  Gly Ser Val 
    2435                 2440                 2445             


Gly Pro  Pro Gly Ala Ser Gly  Leu Lys Gly Asp Lys  Gly Asp Pro 
    2450                 2455                 2460             


Gly Val  Gly Leu Pro Gly Pro  Arg Gly Glu Arg Gly  Glu Pro Gly 
    2465                 2470                 2475             


Ile Arg  Gly Glu Asp Gly Arg  Pro Gly Gln Glu Gly  Pro Arg Gly 
    2480                 2485                 2490             


Leu Thr  Gly Pro Pro Gly Ser  Arg Gly Glu Arg Gly  Glu Lys Gly 
    2495                 2500                 2505             


Asp Val  Gly Ser Ala Gly Leu  Lys Gly Asp Lys Gly  Asp Ser Ala 
    2510                 2515                 2520             


Val Ile  Leu Gly Pro Pro Gly  Pro Arg Gly Ala Lys  Gly Asp Met 
    2525                 2530                 2535             


Gly Glu  Arg Gly Pro Arg Gly  Leu Asp Gly Asp Lys  Gly Pro Arg 
    2540                 2545                 2550             


Gly Asp  Asn Gly Asp Pro Gly  Asp Lys Gly Ser Lys  Gly Glu Pro 
    2555                 2560                 2565             


Gly Asp  Lys Gly Ser Ala Gly  Leu Pro Gly Leu Arg  Gly Leu Leu 
    2570                 2575                 2580             


Gly Pro  Gln Gly Gln Pro Gly  Ala Ala Gly Ile Pro  Gly Asp Pro 
    2585                 2590                 2595             


Gly Ser  Pro Gly Lys Asp Gly  Val Pro Gly Ile Arg  Gly Glu Lys 
    2600                 2605                 2610             


Gly Asp  Val Gly Phe Met Gly  Pro Arg Gly Leu Lys  Gly Glu Arg 
    2615                 2620                 2625             


Gly Val  Lys Gly Ala Cys Gly  Leu Asp Gly Glu Lys  Gly Asp Lys 
    2630                 2635                 2640             


Gly Glu  Ala Gly Pro Pro Gly  Arg Pro Gly Leu Ala  Gly His Lys 
    2645                 2650                 2655             


Gly Glu  Met Gly Glu Pro Gly  Val Pro Gly Gln Ser  Gly Ala Pro 
    2660                 2665                 2670             


Gly Lys  Glu Gly Leu Ile Gly  Pro Lys Gly Asp Arg  Gly Phe Asp 
    2675                 2680                 2685             


Gly Gln  Pro Gly Pro Lys Gly  Asp Gln Gly Glu Lys  Gly Glu Arg 
    2690                 2695                 2700             


Gly Thr  Pro Gly Ile Gly Gly  Phe Pro Gly Pro Ser  Gly Asn Asp 
    2705                 2710                 2715             


Gly Ser  Ala Gly Pro Pro Gly  Pro Pro Gly Ser Val  Gly Pro Arg 
    2720                 2725                 2730             


Gly Pro  Glu Gly Leu Gln Gly  Gln Lys Gly Glu Arg  Gly Pro Pro 
    2735                 2740                 2745             


Gly Glu  Arg Val Val Gly Ala  Pro Gly Val Pro Gly  Ala Pro Gly 
    2750                 2755                 2760             


Glu Arg  Gly Glu Gln Gly Arg  Pro Gly Pro Ala Gly  Pro Arg Gly 
    2765                 2770                 2775             


Glu Lys  Gly Glu Ala Ala Leu  Thr Glu Asp Asp Ile  Arg Gly Phe 
    2780                 2785                 2790             


Val Arg  Gln Glu Met Ser Gln  His Cys Ala Cys Gln  Gly Gln Phe 
    2795                 2800                 2805             


Ile Ala  Ser Gly Ser Arg Pro  Leu Pro Ser Tyr Ala  Ala Asp Thr 
    2810                 2815                 2820             


Ala Gly  Ser Gln Leu His Ala  Val Pro Val Leu Arg  Val Ser His 
    2825                 2830                 2835             


Ala Glu  Glu Glu Glu Arg Val  Pro Pro Glu Asp Asp  Glu Tyr Ser 
    2840                 2845                 2850             


Glu Tyr  Ser Glu Tyr Ser Val  Glu Glu Tyr Gln Asp  Pro Glu Ala 
    2855                 2860                 2865             


Pro Trp  Asp Ser Asp Asp Pro  Cys Ser Leu Pro Leu  Asp Glu Gly 
    2870                 2875                 2880             


Ser Cys  Thr Ala Tyr Thr Leu  Arg Trp Tyr His Arg  Ala Val Thr 
    2885                 2890                 2895             


Gly Ser  Thr Glu Ala Cys His  Pro Phe Val Tyr Gly  Gly Cys Gly 
    2900                 2905                 2910             


Gly Asn  Ala Asn Arg Phe Gly  Thr Arg Glu Ala Cys  Glu Arg Arg 
    2915                 2920                 2925             


Cys Pro  Pro Arg Val Val Gln  Ser Gln Gly Thr Gly  Thr Ala Gln 
    2930                 2935                 2940             


Asp 
    


<210> 19
<211> 2988
<212> DNA
<213> Homo sapiens

<400> 19
agaagaaggg gagaggaggt tgtgtgggac aaggtgctcc tgacagaagg atgccacagc       60

tgagcctgtc ctcgctgggc ctttggccaa tggcagcatc cccgtggctg ctcctgctgc      120

tggttggggc ctcctggctc ctggcccgca tcctggcctg gacctatacc ttctatgaca      180

actgctgccg cctccggtgt ttcccgcaac ccccgaaacg gaattggttc ttgggtcacc      240

tgggcctgat tcacagctcg gaggaaggtc tcctatacac acaaagcctg gcatgcacct      300

tcggtgatat gtgctgctgg tgggtggggc cctggcacgc aatcgtccgc atcttccacc      360

ccacctacat caagcctgtg ctctttgctc cagctgccat tgtaccaaag gacaaggtct      420

tctacagctt cctgaagccc tggctggggg atgggctcct gctgagtgct ggtgaaaagt      480

ggagccgcca ccgtcggatg ctgacgcctg ccttccattt caacatcctg aagccctata      540

tgaagatttt caatgagagt gtgaacatca tgcatgccaa gtggcagctc ctggcctcag      600

agggtagtgc ccgtctggac atgtttgagc acatcagcct catgaccttg gacagtctgc      660

agaaatgtgt cttcagcttt gacagccatt gccaggagaa gcccagtgaa tatattgccg      720

ccatcttgga gctcagtgcc cttgtgacaa aaagacacca gcagatcctc ctgtacatag      780

acttcctgta ttatctcacc cctgatgggc agcgtttccg cagggcctgc cgcctggtgc      840

acgacttcac agatgccgtc atccaggagc ggcgccgcac cctccctagc cagggtgttg      900

atgacttcct ccaagccaag gccaaatcca agactttgga cttcattgat gtactcctgc      960

tgagcaagga tgaagatggg aagaagttgt ccgatgagga cataagagca gaagctgaca     1020

cctttatgtt tgagggccat gacaccacag ccagtggtct ctcctgggtc ctgtaccacc     1080

ttgcaaagca cccggaatac caggagcgct gtcggcagga ggtgcaagag cttctgaagg     1140

accgtgagcc taaagagatt gaatgggacg acctggccca gctgcccttc ctgaccatgt     1200

gcattaagga gagcctgagg ctgcatcccc cagtccctgc cgtctctcgc tgctgcaccc     1260

aagacattgt gctcccagac ggccgggtca tccccaaagg cattatctgc ctcatcagtg     1320

tttttggaac ccatcacaac ccagccgtgt ggccggaccc tgaggtctat gacccctttc     1380

gctttgaccc aaagaacatc aaggagaggt cacctctggc ttttattccc ttctcagcag     1440

ggcccaggaa ctgcatcggg caggcgttcg cgatggcgga gatgaaggtg gtcctggggc     1500

tcacgctgct gcgcttccgc gtcctgcctg accacaccga gccccgcagg aagccggagc     1560

tggtcctgcg cgcagagggc ggactttggc tgcgggtgga gcccctgagc tgagttctgc     1620

agagacccac tctgacccca ctaaaatgac ccctgattca tcaaaagtga ggcctagaat     1680

taccctaaga ccctgttcca cagtcctgta ttccatccta gatatctact caaaataatt     1740

gagacaagtg ttcaaacaga aagacgcttg tgcgtgaatg ttcatggcag ccctattcac     1800

agtagccaaa cgatgaaaac aaccccaagc tatatattac cagatgaaag gataaacaaa     1860

atatggtcca tccatacaat ggagtattac acagccataa aaaggaatga agcagtgatc     1920

cccactacac tgtggatgaa ccttgaatgc atgatactga atgaaagaca tcagatgcaa     1980

aaggtcacat agtgtactgt ccttttatat gaaatttcca gaacaggcca atctgaagag     2040

atgtatagtg gattggtggc tttcagcagc tgtggggagg tgggactgag gagcgactgc     2100

taatcaggat ggggtttcct cctgggatgg tgaaaatgtt ccggacctag atagtgatga     2160

aggtagcacg acactgtgag tgcactaaat gctattgaat tggacacttt agaatggttg     2220

aaatagtgat ttttatgtga attctaccta aacatgctat tacagctcat atatactttt     2280

tccatctgga ttcttcacaa aagaatatgt tgtgagcatc tttccatgat attaaatcat     2340

cttaggaaac attattttgt gttcttcaaa atgtgcatgt taagtattca aatcagtctt     2400

aaatttttaa aaatatgtaa ttttagaaaa taatttaaaa ggttttgttt cagtttgtaa     2460

gatttctttt ctggcacttt aatggcttga ggtatcatta tcagttacaa attgagttat     2520

tcttcatcaa atgacttttg gagtagagat tttattttta tagcaataga tgcacagata     2580

ttcctgtaag atacaggtgt ggttagacac ttttctagaa caggcatgcc ctgcaaactc     2640

cacagacact gactgttttt gtcctattaa gaagtagacc actgagaagg gagaaggtga     2700

cattttagct ttcccaggta aaagtggttt tcatcctcac accaatttta tggactggac     2760

gttaactctc ttgctcaagg tcactctgag tggaagagtg gggataaatc tggttcgttt     2820

ggcatcagag gccatgactt ttcctaccac agaagtaatt ttcaaagtaa gtctctgccc     2880

taggcacatc agatcacctg gggaccactc cagagtgagt agacaagact ttgacagggg     2940

tgcctaattt tttttttttt ttgagatgga gtctcgctct gttgccca                  2988


<210> 20
<211> 520
<212> PRT
<213> Homo sapiens

<400> 20
Met Pro Gln Leu Ser Leu Ser Ser Leu Gly Leu Trp Pro Met Ala Ala 
1               5                   10                  15      


Ser Pro Trp Leu Leu Leu Leu Leu Val Gly Ala Ser Trp Leu Leu Ala 
            20                  25                  30          


Arg Ile Leu Ala Trp Thr Tyr Thr Phe Tyr Asp Asn Cys Cys Arg Leu 
        35                  40                  45              


Arg Cys Phe Pro Gln Pro Pro Lys Arg Asn Trp Phe Leu Gly His Leu 
    50                  55                  60                  


Gly Leu Ile His Ser Ser Glu Glu Gly Leu Leu Tyr Thr Gln Ser Leu 
65                  70                  75                  80  


Ala Cys Thr Phe Gly Asp Met Cys Cys Trp Trp Val Gly Pro Trp His 
                85                  90                  95      


Ala Ile Val Arg Ile Phe His Pro Thr Tyr Ile Lys Pro Val Leu Phe 
            100                 105                 110         


Ala Pro Ala Ala Ile Val Pro Lys Asp Lys Val Phe Tyr Ser Phe Leu 
        115                 120                 125             


Lys Pro Trp Leu Gly Asp Gly Leu Leu Leu Ser Ala Gly Glu Lys Trp 
    130                 135                 140                 


Ser Arg His Arg Arg Met Leu Thr Pro Ala Phe His Phe Asn Ile Leu 
145                 150                 155                 160 


Lys Pro Tyr Met Lys Ile Phe Asn Glu Ser Val Asn Ile Met His Ala 
                165                 170                 175     


Lys Trp Gln Leu Leu Ala Ser Glu Gly Ser Ala Arg Leu Asp Met Phe 
            180                 185                 190         


Glu His Ile Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe 
        195                 200                 205             


Ser Phe Asp Ser His Cys Gln Glu Lys Pro Ser Glu Tyr Ile Ala Ala 
    210                 215                 220                 


Ile Leu Glu Leu Ser Ala Leu Val Thr Lys Arg His Gln Gln Ile Leu 
225                 230                 235                 240 


Leu Tyr Ile Asp Phe Leu Tyr Tyr Leu Thr Pro Asp Gly Gln Arg Phe 
                245                 250                 255     


Arg Arg Ala Cys Arg Leu Val His Asp Phe Thr Asp Ala Val Ile Gln 
            260                 265                 270         


Glu Arg Arg Arg Thr Leu Pro Ser Gln Gly Val Asp Asp Phe Leu Gln 
        275                 280                 285             


Ala Lys Ala Lys Ser Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu 
    290                 295                 300                 


Ser Lys Asp Glu Asp Gly Lys Lys Leu Ser Asp Glu Asp Ile Arg Ala 
305                 310                 315                 320 


Glu Ala Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ser Gly 
                325                 330                 335     


Leu Ser Trp Val Leu Tyr His Leu Ala Lys His Pro Glu Tyr Gln Glu 
            340                 345                 350         


Arg Cys Arg Gln Glu Val Gln Glu Leu Leu Lys Asp Arg Glu Pro Lys 
        355                 360                 365             


Glu Ile Glu Trp Asp Asp Leu Ala Gln Leu Pro Phe Leu Thr Met Cys 
    370                 375                 380                 


Ile Lys Glu Ser Leu Arg Leu His Pro Pro Val Pro Ala Val Ser Arg 
385                 390                 395                 400 


Cys Cys Thr Gln Asp Ile Val Leu Pro Asp Gly Arg Val Ile Pro Lys 
                405                 410                 415     


Gly Ile Ile Cys Leu Ile Ser Val Phe Gly Thr His His Asn Pro Ala 
            420                 425                 430         


Val Trp Pro Asp Pro Glu Val Tyr Asp Pro Phe Arg Phe Asp Pro Lys 
        435                 440                 445             


Asn Ile Lys Glu Arg Ser Pro Leu Ala Phe Ile Pro Phe Ser Ala Gly 
    450                 455                 460                 


Pro Arg Asn Cys Ile Gly Gln Ala Phe Ala Met Ala Glu Met Lys Val 
465                 470                 475                 480 


Val Leu Gly Leu Thr Leu Leu Arg Phe Arg Val Leu Pro Asp His Thr 
                485                 490                 495     


Glu Pro Arg Arg Lys Pro Glu Leu Val Leu Arg Ala Glu Gly Gly Leu 
            500                 505                 510         


Trp Leu Arg Val Glu Pro Leu Ser 
        515                 520 


<210> 21
<211> 6914
<212> DNA
<213> Homo sapiens

<400> 21
gcggccgccg cccagccagg tgcaaaatgc cgtgtcattg ggagactccg cagccggagc       60

attagattac agctcgacgg agctcgggaa gggcggcggg ggtggaagat gagcagaagc      120

ccctgttctc ggaacgccgg ctgacaagcg gggtgagcgc agccggggcg gggacccagc      180

ctagcccact ggagcagccg ggggtggccc gttccccttt aagagcaact gctctaagcc      240

aggagccaga gattcgagcc ggcctcgccc agccagccct ctccagcgag gggacccaca      300

agcggcgcct cggccctccc gacctttccg agccctcttt gcgccctggg cgcacggggc      360

cctacacgcg ccaagcatgc tgagggtctt catcctctat gccgagaacg tccacacacc      420

cgacaccgac atcagcgatg cctactgctc cgcggtgttt gcaggggtga agaagagaac      480

caaagtcatc aagaacagcg tgaaccctgt atggaatgag ggatttgaat gggacctcaa      540

gggcatcccc ctggaccagg gctctgagct tcatgtggtg gtcaaagacc atgagacgat      600

ggggaggaac aggttcctgg gggaagccaa ggtcccactc cgagaggtcc tcgccacccc      660

tagtctgtcc gccagcttca atgcccccct gctggacacc aagaagcagc ccacaggggc      720

ctcgctggtc ctgcaggtgt cctacacacc gctgcctgga gctgtgcccc tgttcccgcc      780

ccctactcct ctggagccct ccccgactct gcctgacctg gatgtagtgg cagacacagg      840

aggagaggaa gacacagagg accagggact cactggagat gaggcggagc cattcctgga      900

tcaaagcgga ggcccggggg ctcccaccac cccaaggaaa ctaccttcac gtcctccgcc      960

ccactacccc gggatcaaaa gaaagcgaag tgcgcctaca tctagaaagc tgctgtcaga     1020

caaaccgcag gatttccaga tcagggtcca ggtgatcgag gggcgccagc tgccgggggt     1080

gaacatcaag cctgtggtca aggttaccgc tgcagggcag accaagcgga cgcggatcca     1140

caagggaaac agcccactct tcaatgagac tcttttcttc aacttgtttg actctcctgg     1200

ggagctgttt gatgagccca tctttatcac ggtggtagac tctcgttctc tcaggacaga     1260

tgctctcctc ggggagttcc ggatggacgt gggcaccatt tacagagagc cccggcacgc     1320

ctatctcagg aagtggctgc tgctctcaga ccctgatgac ttctctgctg gggccagagg     1380

ctacctgaaa acaagccttt gtgtgctggg gcctggggac gaagcgcctc tggagagaaa     1440

agacccctct gaagacaagg aggacattga aagcaacctg ctccggccca caggcgtagc     1500

cctgcgagga gcccacttct gcctgaaggt cttccgggcc gaggacttgc cgcagatgga     1560

cgatgccgtg atggacaacg tgaaacagat ctttggcttc gagagtaaca agaagaactt     1620

ggtggacccc tttgtggagg tcagctttgc ggggaaaatg ctgtgcagca agatcttgga     1680

gaagacggcc aaccctcagt ggaaccagaa catcacactg cctgccatgt ttccctccat     1740

gtgcgaaaaa atgaggattc gtatcataga ctgggaccgc ctgactcaca atgacatcgt     1800

ggctaccacc tacctgagta tgtcgaaaat ctctgcccct ggaggagaaa tagaagagga     1860

gcctgcaggt gctgtcaagc cttcgaaagc ctcagacttg gatgactacc tgggcttcct     1920

ccccactttt gggccctgct acatcaacct ctatggcagt cccagagagt tcacaggctt     1980

cccagacccc tacacagagc tcaacacagg caagggggaa ggtgtggctt atcgtggccg     2040

gcttctgctc tccctggaga ccaagctggt ggagcacagt gaacagaagg tggaggacct     2100

tcctgcggat gacatcctcc gggtggagaa gtaccttagg aggcgcaagt actccctgtt     2160

tgcggccttc tactcagcca ccatgctgca ggatgtggat gatgccatcc agtttgaggt     2220

cagcatcggg aactacggga acaagttcga catgacctgc ctgccgctgg cctccaccac     2280

tcagtacagc cgtgcagtct ttgacgggtg ccactactac tacctaccct ggggtaacgt     2340

gaaacctgtg gtggtgctgt catcctactg ggaggacatc agccatagaa tcgagactca     2400

gaaccagctg cttgggattg ctgaccggct ggaagctggc ctggagcagg tccacctggc     2460

cctgaaggcg cagtgctcca cggaggacgt ggactcgctg gtggctcagc tgacggatga     2520

gctcatcgca ggctgcagcc agcctctggg tgacatccat gagacaccct ctgccaccca     2580

cctggaccag tacctgtacc agctgcgcac ccatcacctg agccaaatca ctgaggctgc     2640

cctggccctg aagctcggcc acagtgagct ccctgcagct ctggagcagg cggaggactg     2700

gctcctgcgt ctgcgtgccc tggcagagga gccccagaac agcctgccgg acatcgtcat     2760

ctggatgctg cagggagaca agcgtgtggc ataccagcgg gtgcccgccc accaagtcct     2820

cttctcccgg cggggtgcca actactgtgg caagaattgt gggaagctac agacaatctt     2880

tctgaaatat ccgatggaga aggtgcctgg cgcccggatg ccagtgcaga tacgggtcaa     2940

gctgtggttt gggctctcag tggatgagaa ggagttcaac cagtttgctg aggggaagct     3000

gtctgtcttt gctgaaacct atgagaacga gactaagttg gcccttgttg ggaactgggg     3060

cacaacgggc ctcacctacc ccaagttttc tgacgtcacg ggcaagatca agctacccaa     3120

ggacagcttc cgcccctcgg ccggctggac ctgggctgga gattggttcg tgtgtccgga     3180

gaagactctg ctccatgaca tggacgccgg tcacctgagc ttcgtggaag aggtgtttga     3240

gaaccagacc cggcttcccg gaggccagtg gatctacatg agtgacaact acaccgatgt     3300

gaacggggag aaggtgcttc ccaaggatga cattgagtgc ccactgggct ggaagtggga     3360

agatgaggaa tggtccacag acctcaaccg ggctgtcgat gagcaaggct gggagtatag     3420

catcaccatc cccccggagc ggaagccgaa gcactgggtc cctgctgaga agatgtacta     3480

cacacaccga cggcggcgct gggtgcgcct gcgcaggagg gatctcagcc aaatggaagc     3540

actgaaaagg cacaggcagg cggaggcgga gggcgagggc tgggagtacg cctctctttt     3600

tggctggaag ttccacctcg agtaccgcaa gacagatgcc ttccgccgcc gccgctggcg     3660

ccgtcgcatg gagccactgg agaagacggg gcctgcagct gtgtttgccc ttgagggggc     3720

cctgggcggc gtgatggatg acaagagtga agattccatg tccgtctcca ccttgagctt     3780

cggtgtgaac agacccacga tttcctgcat attcgactat gggaaccgct accatctacg     3840

ctgctacatg taccaggccc gggacctggc tgcgatggac aaggactctt tttctgatcc     3900

ctatgccatc gtctccttcc tgcaccagag ccagaagacg gtggtggtga agaacaccct     3960

taaccccacc tgggaccaga cgctcatctt ctacgagatc gagatctttg gcgagccggc     4020

cacagttgct gagcaaccgc ccagcattgt ggtggagctg tacgaccatg acacttatgg     4080

tgcagacgag tttatgggtc gctgcatctg tcaaccgagt ctggaacgga tgccacggct     4140

ggcctggttc ccactgacga ggggcagcca gccgtcgggg gagctgctgg cctcttttga     4200

gctcatccag agagagaagc cggccatcca ccatattcct ggttttgagg tgcaggagac     4260

atcaaggatc ctggatgagt ctgaggacac agacctgccc tacccaccac cccagaggga     4320

ggccaacatc tacatggttc ctcagaacat caagccagcg ctccagcgta ccgccatcga     4380

gatcctggca tggggcctgc ggaacatgaa gagttaccag ctggccaaca tctcctcccc     4440

cagcctcgtg gtagagtgtg ggggccagac ggtgcagtcc tgtgtcatca ggaacctccg     4500

gaagaacccc aactttgaca tctgcaccct cttcatggaa gtgatgctgc ccagggagga     4560

gctctactgc ccccccatca ccgtcaaggt catcgataac cgccagtttg gccgccggcc     4620

tgtggtgggc cagtgtacca tccgctccct ggagagcttc ctgtgtgacc cctactcggc     4680

ggagagtcca tccccacagg gtggcccaga cgatgtgagc ctactcagtc ctggggaaga     4740

cgtgctcatc gacattgatg acaaggagcc cctcatcccc atccaggagg aagagttcat     4800

cgattggtgg agcaaattct ttgcctccat aggggagagg gaaaagtgcg gctcctacct     4860

ggagaaggat tttgacaccc tgaaggtcta tgacacacag ctggagaatg tggaggcctt     4920

tgagggcctg tctgactttt gtaacacctt caagctgtac cggggcaaga cgcaggagga     4980

gacagaagat ccatctgtga ttggtgaatt taagggcctc ttcaaaattt atcccctccc     5040

agaagaccca gccatcccca tgcccccaag acagttccac cagctggccg cccagggacc     5100

ccaggagtgc ttggtccgta tctacattgt ccgagcattt ggcctgcagc ccaaggaccc     5160

caatggaaag tgtgatcctt acatcaagat ctccataggg aagaaatcag tgagtgacca     5220

ggataactac atcccctgca cgctggagcc cgtatttgga aagatgttcg agctgacctg     5280

cactctgcct ctggagaagg acctaaagat cactctctat gactatgacc tcctctccaa     5340

ggacgaaaag atcggtgaga cggtcgtcga cctggagaac aggctgctgt ccaagtttgg     5400

ggctcgctgt ggactcccac agacctactg tgtctctgga ccgaaccagt ggcgggacca     5460

gctccgcccc tcccagctcc tccacctctt ctgccagcag catagagtca aggcacctgt     5520

gtaccggaca gaccgtgtaa tgtttcagga taaagaatat tccattgaag agatagaggc     5580

tggcaggatc ccaaacccac acctgggccc agtggaggag cgtctggctc tgcatgtgct     5640

tcagcagcag ggcctggtcc cggagcacgt ggagtcacgg cccctctaca gccccctgca     5700

gccagacatc gagcagggga agctgcagat gtgggtcgac ctatttccga aggccctggg     5760

gcggcctgga cctcccttca acatcacccc acggagagcc agaaggtttt tcctgcgttg     5820

tattatctgg aataccagag atgtgatcct ggatgacctg agcctcacgg gggagaagat     5880

gagcgacatt tatgtgaaag gttggatgat tggctttgaa gaacacaagc aaaagacaga     5940

cgtgcattat cgttccctgg gaggtgaagg caacttcaac tggaggttca ttttcccctt     6000

cgactacctg ccagctgagc aagtctgtac cattgccaag aaggatgcct tctggaggct     6060

ggacaagact gagagcaaaa tcccagcacg agtggtgttc cagatctggg acaatgacaa     6120

gttctccttt gatgattttc tgggctccct gcagctcgat ctcaaccgca tgcccaagcc     6180

agccaagaca gccaagaagt gctccttgga ccagctggat gatgctttcc acccagaatg     6240

gtttgtgtcc ctttttgagc agaaaacagt gaagggctgg tggccctgtg tagcagaaga     6300

gggtgagaag aaaatactgg cgggcaagct ggaaatgacc ttggagattg tagcagagag     6360

tgagcatgag gagcggcctg ctggccaggg ccgggatgag cccaacatga accctaagct     6420

tgaggaccca aggcgccccg acacctcctt cctgtggttt acctccccat acaagaccat     6480

gaagttcatc ctgtggcggc gtttccggtg ggccatcatc ctcttcatca tcctcttcat     6540

cctgctgctg ttcctggcca tcttcatcta cgccttcccg aactatgctg ccatgaagct     6600

ggtgaagccc ttcagctgag gactctcctg ccctgtagaa ggggccgtgg ggtcccctcc     6660

agcatgggac tggcctgcct cctccgccca gctcggcgag ctcctccaga cctcctaggc     6720

ctgattgtcc tgccagggtg ggcagacaga cagatggacc ggcccacact cccagagttg     6780

ctaacatgga gctctgagat caccccactt ccatcatttc cttctccccc aacccaacgc     6840

ttttttggat cagctcagac atatttcagt ataaaacagt tggaaccaca aaaaaaaaaa     6900

aaaaaaaaaa aaaa                                                       6914


<210> 22
<211> 2080
<212> PRT
<213> Homo sapiens

<400> 22
Met Leu Arg Val Phe Ile Leu Tyr Ala Glu Asn Val His Thr Pro Asp 
1               5                   10                  15      


Thr Asp Ile Ser Asp Ala Tyr Cys Ser Ala Val Phe Ala Gly Val Lys 
            20                  25                  30          


Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn Glu 
        35                  40                  45              


Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser Glu 
    50                  55                  60                  


Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg Phe 
65                  70                  75                  80  


Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro Ser 
                85                  90                  95      


Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln Pro 
            100                 105                 110         


Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro Gly 
        115                 120                 125             


Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro Thr 
    130                 135                 140                 


Leu Pro Asp Leu Asp Val Val Ala Asp Thr Gly Gly Glu Glu Asp Thr 
145                 150                 155                 160 


Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln 
                165                 170                 175     


Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg 
            180                 185                 190         


Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr 
        195                 200                 205             


Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val 
    210                 215                 220                 


Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val 
225                 230                 235                 240 


Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys 
                245                 250                 255     


Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp 
            260                 265                 270         


Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp 
        275                 280                 285             


Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp 
    290                 295                 300                 


Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp 
305                 310                 315                 320 


Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr 
                325                 330                 335     


Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu 
            340                 345                 350         


Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu 
        355                 360                 365             


Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys 
    370                 375                 380                 


Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp 
385                 390                 395                 400 


Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val 
                405                 410                 415     


Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys 
            420                 425                 430         


Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu 
        435                 440                 445             


Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile 
    450                 455                 460                 


Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu 
465                 470                 475                 480 


Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Glu Glu Pro 
                485                 490                 495     


Ala Gly Ala Val Lys Pro Ser Lys Ala Ser Asp Leu Asp Asp Tyr Leu 
            500                 505                 510         


Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr Gly Ser 
        515                 520                 525             


Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu Asn Thr 
    530                 535                 540                 


Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu Ser Leu 
545                 550                 555                 560 


Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp Leu Pro 
                565                 570                 575     


Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg Lys Tyr 
            580                 585                 590         


Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp Val Asp 
        595                 600                 605             


Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe 
    610                 615                 620                 


Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala 
625                 630                 635                 640 


Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn Val Lys 
                645                 650                 655     


Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His Arg Ile 
            660                 665                 670         


Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu Ala Gly 
        675                 680                 685             


Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr Glu Asp 
    690                 695                 700                 


Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala Gly Cys 
705                 710                 715                 720 


Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr His Leu 
                725                 730                 735     


Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln Ile Thr 
            740                 745                 750         


Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro Ala Ala 
        755                 760                 765             


Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu Ala Glu 
    770                 775                 780                 


Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu Gln Gly 
785                 790                 795                 800 


Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val Leu Phe 
                805                 810                 815     


Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys Leu Gln 
            820                 825                 830         


Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala Arg Met 
        835                 840                 845             


Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val Asp Glu 
    850                 855                 860                 


Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe Ala Glu 
865                 870                 875                 880 


Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp Gly Thr 
                885                 890                 895     


Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys Ile Lys 
            900                 905                 910         


Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp Ala Gly 
        915                 920                 925             


Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met Asp Ala 
    930                 935                 940                 


Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr Arg Leu 
945                 950                 955                 960 


Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp Val Asn 
                965                 970                 975     


Gly Glu Lys Val Leu Pro Lys Asp Asp Ile Glu Cys Pro Leu Gly Trp 
            980                 985                 990         


Lys Trp Glu Asp Glu Glu Trp Ser  Thr Asp Leu Asn Arg  Ala Val Asp 
        995                 1000                 1005             


Glu Gln  Gly Trp Glu Tyr Ser  Ile Thr Ile Pro Pro  Glu Arg Lys 
    1010                 1015                 1020             


Pro Lys  His Trp Val Pro Ala  Glu Lys Met Tyr Tyr  Thr His Arg 
    1025                 1030                 1035             


Arg Arg  Arg Trp Val Arg Leu  Arg Arg Arg Asp Leu  Ser Gln Met 
    1040                 1045                 1050             


Glu Ala  Leu Lys Arg His Arg  Gln Ala Glu Ala Glu  Gly Glu Gly 
    1055                 1060                 1065             


Trp Glu  Tyr Ala Ser Leu Phe  Gly Trp Lys Phe His  Leu Glu Tyr 
    1070                 1075                 1080             


Arg Lys  Thr Asp Ala Phe Arg  Arg Arg Arg Trp Arg  Arg Arg Met 
    1085                 1090                 1095             


Glu Pro  Leu Glu Lys Thr Gly  Pro Ala Ala Val Phe  Ala Leu Glu 
    1100                 1105                 1110             


Gly Ala  Leu Gly Gly Val Met  Asp Asp Lys Ser Glu  Asp Ser Met 
    1115                 1120                 1125             


Ser Val  Ser Thr Leu Ser Phe  Gly Val Asn Arg Pro  Thr Ile Ser 
    1130                 1135                 1140             


Cys Ile  Phe Asp Tyr Gly Asn  Arg Tyr His Leu Arg  Cys Tyr Met 
    1145                 1150                 1155             


Tyr Gln  Ala Arg Asp Leu Ala  Ala Met Asp Lys Asp  Ser Phe Ser 
    1160                 1165                 1170             


Asp Pro  Tyr Ala Ile Val Ser  Phe Leu His Gln Ser  Gln Lys Thr 
    1175                 1180                 1185             


Val Val  Val Lys Asn Thr Leu  Asn Pro Thr Trp Asp  Gln Thr Leu 
    1190                 1195                 1200             


Ile Phe  Tyr Glu Ile Glu Ile  Phe Gly Glu Pro Ala  Thr Val Ala 
    1205                 1210                 1215             


Glu Gln  Pro Pro Ser Ile Val  Val Glu Leu Tyr Asp  His Asp Thr 
    1220                 1225                 1230             


Tyr Gly  Ala Asp Glu Phe Met  Gly Arg Cys Ile Cys  Gln Pro Ser 
    1235                 1240                 1245             


Leu Glu  Arg Met Pro Arg Leu  Ala Trp Phe Pro Leu  Thr Arg Gly 
    1250                 1255                 1260             


Ser Gln  Pro Ser Gly Glu Leu  Leu Ala Ser Phe Glu  Leu Ile Gln 
    1265                 1270                 1275             


Arg Glu  Lys Pro Ala Ile His  His Ile Pro Gly Phe  Glu Val Gln 
    1280                 1285                 1290             


Glu Thr  Ser Arg Ile Leu Asp  Glu Ser Glu Asp Thr  Asp Leu Pro 
    1295                 1300                 1305             


Tyr Pro  Pro Pro Gln Arg Glu  Ala Asn Ile Tyr Met  Val Pro Gln 
    1310                 1315                 1320             


Asn Ile  Lys Pro Ala Leu Gln  Arg Thr Ala Ile Glu  Ile Leu Ala 
    1325                 1330                 1335             


Trp Gly  Leu Arg Asn Met Lys  Ser Tyr Gln Leu Ala  Asn Ile Ser 
    1340                 1345                 1350             


Ser Pro  Ser Leu Val Val Glu  Cys Gly Gly Gln Thr  Val Gln Ser 
    1355                 1360                 1365             


Cys Val  Ile Arg Asn Leu Arg  Lys Asn Pro Asn Phe  Asp Ile Cys 
    1370                 1375                 1380             


Thr Leu  Phe Met Glu Val Met  Leu Pro Arg Glu Glu  Leu Tyr Cys 
    1385                 1390                 1395             


Pro Pro  Ile Thr Val Lys Val  Ile Asp Asn Arg Gln  Phe Gly Arg 
    1400                 1405                 1410             


Arg Pro  Val Val Gly Gln Cys  Thr Ile Arg Ser Leu  Glu Ser Phe 
    1415                 1420                 1425             


Leu Cys  Asp Pro Tyr Ser Ala  Glu Ser Pro Ser Pro  Gln Gly Gly 
    1430                 1435                 1440             


Pro Asp  Asp Val Ser Leu Leu  Ser Pro Gly Glu Asp  Val Leu Ile 
    1445                 1450                 1455             


Asp Ile  Asp Asp Lys Glu Pro  Leu Ile Pro Ile Gln  Glu Glu Glu 
    1460                 1465                 1470             


Phe Ile  Asp Trp Trp Ser Lys  Phe Phe Ala Ser Ile  Gly Glu Arg 
    1475                 1480                 1485             


Glu Lys  Cys Gly Ser Tyr Leu  Glu Lys Asp Phe Asp  Thr Leu Lys 
    1490                 1495                 1500             


Val Tyr  Asp Thr Gln Leu Glu  Asn Val Glu Ala Phe  Glu Gly Leu 
    1505                 1510                 1515             


Ser Asp  Phe Cys Asn Thr Phe  Lys Leu Tyr Arg Gly  Lys Thr Gln 
    1520                 1525                 1530             


Glu Glu  Thr Glu Asp Pro Ser  Val Ile Gly Glu Phe  Lys Gly Leu 
    1535                 1540                 1545             


Phe Lys  Ile Tyr Pro Leu Pro  Glu Asp Pro Ala Ile  Pro Met Pro 
    1550                 1555                 1560             


Pro Arg  Gln Phe His Gln Leu  Ala Ala Gln Gly Pro  Gln Glu Cys 
    1565                 1570                 1575             


Leu Val  Arg Ile Tyr Ile Val  Arg Ala Phe Gly Leu  Gln Pro Lys 
    1580                 1585                 1590             


Asp Pro  Asn Gly Lys Cys Asp  Pro Tyr Ile Lys Ile  Ser Ile Gly 
    1595                 1600                 1605             


Lys Lys  Ser Val Ser Asp Gln  Asp Asn Tyr Ile Pro  Cys Thr Leu 
    1610                 1615                 1620             


Glu Pro  Val Phe Gly Lys Met  Phe Glu Leu Thr Cys  Thr Leu Pro 
    1625                 1630                 1635             


Leu Glu  Lys Asp Leu Lys Ile  Thr Leu Tyr Asp Tyr  Asp Leu Leu 
    1640                 1645                 1650             


Ser Lys  Asp Glu Lys Ile Gly  Glu Thr Val Val Asp  Leu Glu Asn 
    1655                 1660                 1665             


Arg Leu  Leu Ser Lys Phe Gly  Ala Arg Cys Gly Leu  Pro Gln Thr 
    1670                 1675                 1680             


Tyr Cys  Val Ser Gly Pro Asn  Gln Trp Arg Asp Gln  Leu Arg Pro 
    1685                 1690                 1695             


Ser Gln  Leu Leu His Leu Phe  Cys Gln Gln His Arg  Val Lys Ala 
    1700                 1705                 1710             


Pro Val  Tyr Arg Thr Asp Arg  Val Met Phe Gln Asp  Lys Glu Tyr 
    1715                 1720                 1725             


Ser Ile  Glu Glu Ile Glu Ala  Gly Arg Ile Pro Asn  Pro His Leu 
    1730                 1735                 1740             


Gly Pro  Val Glu Glu Arg Leu  Ala Leu His Val Leu  Gln Gln Gln 
    1745                 1750                 1755             


Gly Leu  Val Pro Glu His Val  Glu Ser Arg Pro Leu  Tyr Ser Pro 
    1760                 1765                 1770             


Leu Gln  Pro Asp Ile Glu Gln  Gly Lys Leu Gln Met  Trp Val Asp 
    1775                 1780                 1785             


Leu Phe  Pro Lys Ala Leu Gly  Arg Pro Gly Pro Pro  Phe Asn Ile 
    1790                 1795                 1800             


Thr Pro  Arg Arg Ala Arg Arg  Phe Phe Leu Arg Cys  Ile Ile Trp 
    1805                 1810                 1815             


Asn Thr  Arg Asp Val Ile Leu  Asp Asp Leu Ser Leu  Thr Gly Glu 
    1820                 1825                 1830             


Lys Met  Ser Asp Ile Tyr Val  Lys Gly Trp Met Ile  Gly Phe Glu 
    1835                 1840                 1845             


Glu His  Lys Gln Lys Thr Asp  Val His Tyr Arg Ser  Leu Gly Gly 
    1850                 1855                 1860             


Glu Gly  Asn Phe Asn Trp Arg  Phe Ile Phe Pro Phe  Asp Tyr Leu 
    1865                 1870                 1875             


Pro Ala  Glu Gln Val Cys Thr  Ile Ala Lys Lys Asp  Ala Phe Trp 
    1880                 1885                 1890             


Arg Leu  Asp Lys Thr Glu Ser  Lys Ile Pro Ala Arg  Val Val Phe 
    1895                 1900                 1905             


Gln Ile  Trp Asp Asn Asp Lys  Phe Ser Phe Asp Asp  Phe Leu Gly 
    1910                 1915                 1920             


Ser Leu  Gln Leu Asp Leu Asn  Arg Met Pro Lys Pro  Ala Lys Thr 
    1925                 1930                 1935             


Ala Lys  Lys Cys Ser Leu Asp  Gln Leu Asp Asp Ala  Phe His Pro 
    1940                 1945                 1950             


Glu Trp  Phe Val Ser Leu Phe  Glu Gln Lys Thr Val  Lys Gly Trp 
    1955                 1960                 1965             


Trp Pro  Cys Val Ala Glu Glu  Gly Glu Lys Lys Ile  Leu Ala Gly 
    1970                 1975                 1980             


Lys Leu  Glu Met Thr Leu Glu  Ile Val Ala Glu Ser  Glu His Glu 
    1985                 1990                 1995             


Glu Arg  Pro Ala Gly Gln Gly  Arg Asp Glu Pro Asn  Met Asn Pro 
    2000                 2005                 2010             


Lys Leu  Glu Asp Pro Arg Arg  Pro Asp Thr Ser Phe  Leu Trp Phe 
    2015                 2020                 2025             


Thr Ser  Pro Tyr Lys Thr Met  Lys Phe Ile Leu Trp  Arg Arg Phe 
    2030                 2035                 2040             


Arg Trp  Ala Ile Ile Leu Phe  Ile Ile Leu Phe Ile  Leu Leu Leu 
    2045                 2050                 2055             


Phe Leu  Ala Ile Phe Ile Tyr  Ala Phe Pro Asn Tyr  Ala Ala Met 
    2060                 2065                 2070             


Lys Leu  Val Lys Pro Phe Ser  
    2075                 2080 


<210> 23
<211> 2974
<212> DNA
<213> Homo sapiens

<400> 23
agaagccccg cagccgccgc gcggagaaca gcgacagccg agcgcccggt ccgcctgtct       60

gccggtgggt ctgcctgccc gcgcagcaga cccggggcgg ccgcgggagc ccgcgccccg      120

cccgccgcgc ctctgccggg acccacccgc agcggagggc tgagcccgcc ggcggctccc      180

cggagctcac ccacctccgc gcgccggagc gcaggcaaaa ggggaggaaa ggctcctctc      240

tttagtcacc actctcgccc tctccaagaa tttgtttaac aaagcgctga ggaaagagaa      300

cgtcttcttg aattctttag taggggcgga gtctgctgct gccctgcgct gccacctcgg      360

ctacactgcc ctccgcgacg acccctgacc agccggggtc acgtccggga gacgggatca      420

tgaagcgctc ggtagccgtc tggctcttgg tcgggctcag cctcggtgtc ccccagttcg      480

gcaaaggtga tatttgtgat cccaatccat gtgaaaatgg aggtatctgt ttgccaggat      540

tggctgatgg ttccttttcc tgtgagtgtc cagatggctt cacagacccc aactgttcta      600

gtgttgtgga ggttgcatca gatgaagaag aaccaacttc agcaggtccc tgcactccta      660

atccatgcca taatggagga acctgtgaaa taagtgaagc ataccgaggg gatacattca      720

taggctatgt ttgtaaatgt ccccgaggat ttaatgggat tcactgtcag cacaacataa      780

atgaatgcga agttgagcct tgcaaaaatg gtggaatatg tacagatctt gttgctaact      840

attcctgtga gtgcccaggc gaatttatgg gaagaaattg tcaatacaaa tgctcaggcc      900

cactgggaat tgaaggtgga attatatcaa accagcaaat cacagcttcc tctactcacc      960

gagctctttt tggactccaa aaatggtatc cctactatgc acgtcttaat aagaaggggc     1020

ttataaatgc gtggacagct gcagaaaatg acagatggcc gtggattcag ataaatttgc     1080

aaaggaaaat gagagttact ggtgtgatta cccaaggagc caagaggatt ggaagcccag     1140

agtatataaa atcctacaaa attgcctaca gtaatgatgg aaagacttgg gcaatgtaca     1200

aagtgaaagg caccaatgaa gacatggtgt ttcgtggaaa cattgataac aacactccat     1260

atgctaactc tttcacaccc cccataaaag ctcagtatgt aagactctat ccccaagttt     1320

gtcgaagaca ttgcactttg cgaatggaac ttcttggctg tgaactgtcg ggttgttctg     1380

agcctctggg tatgaaatca ggacatatac aagactatca gatcactgcc tccagcatct     1440

tcagaacgct caacatggac atgttcactt gggaaccaag gaaagctcgg ctggacaagc     1500

aaggcaaagt gaatgcctgg acctctggcc acaatgacca gtcacaatgg ttacaggtgg     1560

atcttcttgt tccaaccaaa gtgactggca tcattacaca aggagctaaa gattttggtc     1620

atgtacagtt tgttggctcc tacaaactgg cttacagcaa tgatggagaa cactggactg     1680

tataccagga tgaaaagcaa agaaaagata aggttttcca gggaaatttt gacaatgaca     1740

ctcacagaaa aaatgtcatc gaccctccca tctatgcacg acacataaga atccttcctt     1800

ggtcctggta cgggaggatc acattgcggt cagagctgct gggctgcaca gaggaggaat     1860

gaggggaggc tacatttcac aaccctcttc cctatttccc taaaagtatc tccatggaat     1920

gaactgtgca aaatctgtag gaaactgaat ggtttttttt tttttttcat gaaaaagtgc     1980

tcaaattatg gtaggcaact aacggtgttt ttaagggggt ctaagcctgc cttttcaatg     2040

atttaatttg attttatttt atccgtcaaa tctcttaagt aacaacacat taagtgtgaa     2100

ttacttttct ctcattgttt cctgaattat tcgcattggt agaaatatat tagggaaaga     2160

aagtagcctt ctttttatag caagagtaaa aaagtctcaa agtcatcaaa taagagcaag     2220

agttgataga gcttttacaa tcaatactca cctaattctg ataaaaggaa tactgcaatg     2280

ttagcaataa gtttttttct tctgtaatga ctctacgtta tcctgtttcc ctgtgcctac     2340

caaacactgt caatgtttat tacaaaattt taaagaagaa tatgtaacat gcagtactga     2400

tattataatt ctcattttac tttcattatt tctaataaga gattatgtga cttctttttc     2460

ttttagttct attctacatt cttaatattg tatattacct gaataattca atttttttct     2520

aattgaattt cctattagtt gactaaaaga agtgtcatgt ttactcatat atgtagaaca     2580

tgactgccta tcagtagatt gatctgtatt taatattcgt taattaaatc tgcagtttta     2640

tttttgaagg aagccataac tatttaattt ccaaataatt gcttcataaa gaatcccata     2700

ctctcagttt gcacaaaaga acaaaaaata tatatgtctc tttaaattta aatcttcatt     2760

tagatggtaa ttacatatcc ttatatttac tttaaaaaat cggcttattt gtttatttta     2820

taaaaaattt agcaaagaaa tattaatata gtgctgcata gtttggccaa gcatactcat     2880

catttctttg ttcagctcca catttcctgt gaaactaaca tcttattgag atttgaaact     2940

ggtggtagtt tcccaggaag gcacaggtgg agtt                                 2974


<210> 24
<211> 480
<212> PRT
<213> Homo sapiens

<400> 24
Met Lys Arg Ser Val Ala Val Trp Leu Leu Val Gly Leu Ser Leu Gly 
1               5                   10                  15      


Val Pro Gln Phe Gly Lys Gly Asp Ile Cys Asp Pro Asn Pro Cys Glu 
            20                  25                  30          


Asn Gly Gly Ile Cys Leu Pro Gly Leu Ala Asp Gly Ser Phe Ser Cys 
        35                  40                  45              


Glu Cys Pro Asp Gly Phe Thr Asp Pro Asn Cys Ser Ser Val Val Glu 
    50                  55                  60                  


Val Ala Ser Asp Glu Glu Glu Pro Thr Ser Ala Gly Pro Cys Thr Pro 
65                  70                  75                  80  


Asn Pro Cys His Asn Gly Gly Thr Cys Glu Ile Ser Glu Ala Tyr Arg 
                85                  90                  95      


Gly Asp Thr Phe Ile Gly Tyr Val Cys Lys Cys Pro Arg Gly Phe Asn 
            100                 105                 110         


Gly Ile His Cys Gln His Asn Ile Asn Glu Cys Glu Val Glu Pro Cys 
        115                 120                 125             


Lys Asn Gly Gly Ile Cys Thr Asp Leu Val Ala Asn Tyr Ser Cys Glu 
    130                 135                 140                 


Cys Pro Gly Glu Phe Met Gly Arg Asn Cys Gln Tyr Lys Cys Ser Gly 
145                 150                 155                 160 


Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln Ile Thr Ala 
                165                 170                 175     


Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp Tyr Pro Tyr 
            180                 185                 190         


Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp Thr Ala Ala 
        195                 200                 205             


Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln Arg Lys Met 
    210                 215                 220                 


Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile Gly Ser Pro 
225                 230                 235                 240 


Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp Gly Lys Thr 
                245                 250                 255     


Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met Val Phe Arg 
            260                 265                 270         


Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe Thr Pro Pro 
        275                 280                 285             


Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys Arg Arg His 
    290                 295                 300                 


Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser Gly Cys Ser 
305                 310                 315                 320 


Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr Gln Ile Thr 
                325                 330                 335     


Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe Thr Trp Glu 
            340                 345                 350         


Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn Ala Trp Thr 
        355                 360                 365             


Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp Leu Leu Val 
    370                 375                 380                 


Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys Asp Phe Gly 
385                 390                 395                 400 


His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser Asn Asp Gly 
                405                 410                 415     


Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys Asp Lys Val 
            420                 425                 430         


Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn Val Ile Asp 
        435                 440                 445             


Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp Ser Trp Tyr 
    450                 455                 460                 


Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys Thr Glu Glu Glu 
465                 470                 475                 480 


<210> 25
<211> 1368
<212> DNA
<213> Homo sapiens

<400> 25
gtggctccag gccggaagag ggagtctgta ggggcgggcc ggctggcgtc ccctttccgg       60

ccggtcccca tggaggcgct ggggaagctg aagcagttcg atgcctaccc caagactttg      120

gaggacttcc gggtcaagac ctgcgggggc gccaccgtga ccattgtcag tggccttctc      180

atgctgctac tgttcctgtc cgagctgcag tattacctca ccacggaggt gcatcctgag      240

ctctacgtgg acaagtcgcg gggagataaa ctgaagatca acatcgatgt actttttccg      300

cacatgcctt gtgcctatct gagtattgat gccatggatg tggccggaga acagcagctg      360

gatgtggaac acaacctgtt caagcaacga ctagataaag atggcatccc cgtgagctca      420

gaggctgagc ggcatgagct tgggaaagtc gaggtgacgg tgtttgaccc tgactccctg      480

gaccctgatc gctgtgagag ctgctatggt gctgaggcag aagatatcaa gtgctgtaac      540

acctgtgaag atgtgcggga ggcatatcgc cgtagaggct gggccttcaa gaacccagat      600

actattgagc agtgccggcg agagggcttc agccagaaga tgcaggagca gaagaatgaa      660

ggctgccagg tgtatggctt cttggaagtc aataaggtgg ccggaaactt ccactttgcc      720

cctgggaaga gcttccagca gtcccatgtg cacgtccatg acttgcagag ctttggcctt      780

gacaacatca acatgaccca ctacatccag cacctgtcat ttggggagga ctatccaggc      840

attgtgaacc ccctggacca caccaatgtc actgcgcccc aagcctccat gatgttccag      900

tactttgtga aggtggtgcc cactgtgtac atgaaggtgg acggagaggt actgaggaca      960

aatcagttct ctgtgaccag acatgagaag gttgccaatg ggctgttggg cgaccaaggc     1020

cttcccggag tcttcgtcct ctatgagctc tcgcccatga tggtgaagct gacggagaag     1080

cacaggtcct tcacccactt cctgacaggt gtgtgcgcca tcattggggg catgttcaca     1140

gtggctggac tcatcgattc gctcatctac cactcagcac gagccatcca gaagaaaatt     1200

gatctaggga agacaacgta gtcaccctcg gtgcttcctc tgtctcctct ttctccctgg     1260

cctgtggttg tcccccagcc tctgccaccc tccacctcct cggtcagccc cagccccagg     1320

ttgataaatc tattgattga ttgtgatagt aaaaaaaaaa aaaaaaaa                  1368


<210> 26
<211> 383
<212> PRT
<213> Homo sapiens

<400> 26
Met Glu Ala Leu Gly Lys Leu Lys Gln Phe Asp Ala Tyr Pro Lys Thr 
1               5                   10                  15      


Leu Glu Asp Phe Arg Val Lys Thr Cys Gly Gly Ala Thr Val Thr Ile 
            20                  25                  30          


Val Ser Gly Leu Leu Met Leu Leu Leu Phe Leu Ser Glu Leu Gln Tyr 
        35                  40                  45              


Tyr Leu Thr Thr Glu Val His Pro Glu Leu Tyr Val Asp Lys Ser Arg 
    50                  55                  60                  


Gly Asp Lys Leu Lys Ile Asn Ile Asp Val Leu Phe Pro His Met Pro 
65                  70                  75                  80  


Cys Ala Tyr Leu Ser Ile Asp Ala Met Asp Val Ala Gly Glu Gln Gln 
                85                  90                  95      


Leu Asp Val Glu His Asn Leu Phe Lys Gln Arg Leu Asp Lys Asp Gly 
            100                 105                 110         


Ile Pro Val Ser Ser Glu Ala Glu Arg His Glu Leu Gly Lys Val Glu 
        115                 120                 125             


Val Thr Val Phe Asp Pro Asp Ser Leu Asp Pro Asp Arg Cys Glu Ser 
    130                 135                 140                 


Cys Tyr Gly Ala Glu Ala Glu Asp Ile Lys Cys Cys Asn Thr Cys Glu 
145                 150                 155                 160 


Asp Val Arg Glu Ala Tyr Arg Arg Arg Gly Trp Ala Phe Lys Asn Pro 
                165                 170                 175     


Asp Thr Ile Glu Gln Cys Arg Arg Glu Gly Phe Ser Gln Lys Met Gln 
            180                 185                 190         


Glu Gln Lys Asn Glu Gly Cys Gln Val Tyr Gly Phe Leu Glu Val Asn 
        195                 200                 205             


Lys Val Ala Gly Asn Phe His Phe Ala Pro Gly Lys Ser Phe Gln Gln 
    210                 215                 220                 


Ser His Val His Val His Asp Leu Gln Ser Phe Gly Leu Asp Asn Ile 
225                 230                 235                 240 


Asn Met Thr His Tyr Ile Gln His Leu Ser Phe Gly Glu Asp Tyr Pro 
                245                 250                 255     


Gly Ile Val Asn Pro Leu Asp His Thr Asn Val Thr Ala Pro Gln Ala 
            260                 265                 270         


Ser Met Met Phe Gln Tyr Phe Val Lys Val Val Pro Thr Val Tyr Met 
        275                 280                 285             


Lys Val Asp Gly Glu Val Leu Arg Thr Asn Gln Phe Ser Val Thr Arg 
    290                 295                 300                 


His Glu Lys Val Ala Asn Gly Leu Leu Gly Asp Gln Gly Leu Pro Gly 
305                 310                 315                 320 


Val Phe Val Leu Tyr Glu Leu Ser Pro Met Met Val Lys Leu Thr Glu 
                325                 330                 335     


Lys His Arg Ser Phe Thr His Phe Leu Thr Gly Val Cys Ala Ile Ile 
            340                 345                 350         


Gly Gly Met Phe Thr Val Ala Gly Leu Ile Asp Ser Leu Ile Tyr His 
        355                 360                 365             


Ser Ala Arg Ala Ile Gln Lys Lys Ile Asp Leu Gly Lys Thr Thr 
    370                 375                 380             


<210> 27
<211> 2483
<212> DNA
<213> Homo sapiens

<400> 27
agttgattgc aggtcctcct ggggccagaa gggtgcctgg gaggccaggt tctggggatc       60

ccctccatcc agaagaacca cctgctcact ctgtcccttc gcctgctgct gggaccatgg      120

gggctggggc cagtgctgag gagaagcact ccagggagct ggaaaagaag ctgaaagagg      180

acgctgagaa ggatgctcga accgtgaagc tgctgcttct gggtgccggt gagtccggga      240

agagcaccat cgtcaagcag atgaagatta tccaccagga cgggtactcg ctggaagagt      300

gcctcgagtt tatcgccatc atctacggca acacgttgca gtccatcctg gccatcgtac      360

gcgccatgac cacactcaac atccagtacg gagactctgc acgccaggac gacgcccgga      420

agctgatgca catggcagac actatcgagg agggcacgat gcccaaggag atgtcggaca      480

tcatccagcg gctgtggaag gactccggta tccaggcctg ttttgagcgc gcctcggagt      540

accagctcaa cgactcggcg ggctactacc tctccgacct ggagcgcctg gtaaccccgg      600

gctacgtgcc caccgagcag gacgtgctgc gctcgcgagt caagaccact ggcatcatcg      660

agacgcagtt ctccttcaag gatctcaact tccggatgtt cgatgtgggc gggcagcgct      720

cggagcgcaa gaagtggatc cactgcttcg agggcgtgac ctgcatcatc ttcatcgcgg      780

cgctgagcgc ctacgacatg gtgctagtgg aggacgacga agtgaaccgc atgcacgaga      840

gcctgcacct gttcaacagc atctgcaacc accgctactt cgccacgacg tccatcgtgc      900

tcttccttaa caagaaggac gtcttcttcg agaagatcaa gaaggcgcac ctcagcatct      960

gtttcccgga ctacgatgga cccaacacct acgaggacgc cggcaactac atcaaggtgc     1020

agttcctcga gctcaacatg cggcgcgacg tgaaggagat ctattcccac atgacgtgcg     1080

ccaccgacac gcagaacgtc aaatttgtct tcgacgctgt caccgacatc atcatcaagg     1140

agaacctcaa agactgtggc ctcttctgag gccagggcct gtgctgcagt cggggacaag     1200

gagcttccgt ctggcaaggc cggggcacaa tttgcactcc cctcagctag acgcacagac     1260

tcagcaataa acctttgcat caggctccag ctgtcctttc ttggtggagg acttaattat     1320

cacaagtcat gggcatttat taagtgccca gtgctgggtt gggcatgaag tgggaagatg     1380

gcccctccca ggaagaagta cctggcctga caaggtgggg cactcttggg ggtatgggac     1440

caactcatgg cttttcacgg gagttgagga gagaggagct gtggaaaata ttcactggga     1500

cagtcttgga tcaagaggga gttttgaggt ggaggctcat tctggcaggg accgtagtgt     1560

ctaccagccc cagaaacatg ggcttatggc cacaggagtt cagtggagca agagcagggg     1620

aggagagacg tggacaggtg cccaaagcca gtcggagggc ctgggctttc tcagaaggtg     1680

atggagagtc ttggaagccc tcgaggcagg aacataattg cagggctggg attagggtga     1740

gggaagtgag gcacactcac cttgggtgca acatttaagg cgatgccaaa aaatttagta     1800

accaaggtaa ataatattag gataatattt ttaaaaatca aatgaatgca aaaccccaca     1860

atgaatgaaa tatcaaaatc caacagagga tcaaacagag gcatgctaag atatattggg     1920

gcttgaagca aagggaaaac tatttgttgc tatatgtttg tagggatttt ttgccagttt     1980

taaaaataca tgtatcataa agtttactat ctcagccact tgccggtgta tagtttggtg     2040

gtgttaagta cattcataat gttgtacaac caccgcaact gttcatctcc agaactcctt     2100

tcctcttgta aaactgtaac tctgtaccca tgaaaaaata accccccatt cctgccttcc     2160

cccggctcct ggcatccacc attctacttt ccatctctat gaatgtgact gctctaagtg     2220

cctcagatgt gtgggtccat gaagtctttg tctttttgca actggcttat ttcacttagc     2280

atcatgtctt caaggtttat tcatgtgtag catatggcag aatctccttc ctttttaagg     2340

ttgaataata ttccattgta tatattccac actttgttta tttattcatc tattgatgaa     2400

tggttacatc tgccttttgg ctattgtgaa taatgctgct atgaacatgg gtgtacaaat     2460

ctctcaaaaa aaaaaaaaaa aaa                                             2483


<210> 28
<211> 350
<212> PRT
<213> Homo sapiens

<400> 28
Met Gly Ala Gly Ala Ser Ala Glu Glu Lys His Ser Arg Glu Leu Glu 
1               5                   10                  15      


Lys Lys Leu Lys Glu Asp Ala Glu Lys Asp Ala Arg Thr Val Lys Leu 
            20                  25                  30          


Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln 
        35                  40                  45              


Met Lys Ile Ile His Gln Asp Gly Tyr Ser Leu Glu Glu Cys Leu Glu 
    50                  55                  60                  


Phe Ile Ala Ile Ile Tyr Gly Asn Thr Leu Gln Ser Ile Leu Ala Ile 
65                  70                  75                  80  


Val Arg Ala Met Thr Thr Leu Asn Ile Gln Tyr Gly Asp Ser Ala Arg 
                85                  90                  95      


Gln Asp Asp Ala Arg Lys Leu Met His Met Ala Asp Thr Ile Glu Glu 
            100                 105                 110         


Gly Thr Met Pro Lys Glu Met Ser Asp Ile Ile Gln Arg Leu Trp Lys 
        115                 120                 125             


Asp Ser Gly Ile Gln Ala Cys Phe Glu Arg Ala Ser Glu Tyr Gln Leu 
    130                 135                 140                 


Asn Asp Ser Ala Gly Tyr Tyr Leu Ser Asp Leu Glu Arg Leu Val Thr 
145                 150                 155                 160 


Pro Gly Tyr Val Pro Thr Glu Gln Asp Val Leu Arg Ser Arg Val Lys 
                165                 170                 175     


Thr Thr Gly Ile Ile Glu Thr Gln Phe Ser Phe Lys Asp Leu Asn Phe 
            180                 185                 190         


Arg Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp Ile 
        195                 200                 205             


His Cys Phe Glu Gly Val Thr Cys Ile Ile Phe Ile Ala Ala Leu Ser 
    210                 215                 220                 


Ala Tyr Asp Met Val Leu Val Glu Asp Asp Glu Val Asn Arg Met His 
225                 230                 235                 240 


Glu Ser Leu His Leu Phe Asn Ser Ile Cys Asn His Arg Tyr Phe Ala 
                245                 250                 255     


Thr Thr Ser Ile Val Leu Phe Leu Asn Lys Lys Asp Val Phe Phe Glu 
            260                 265                 270         


Lys Ile Lys Lys Ala His Leu Ser Ile Cys Phe Pro Asp Tyr Asp Gly 
        275                 280                 285             


Pro Asn Thr Tyr Glu Asp Ala Gly Asn Tyr Ile Lys Val Gln Phe Leu 
    290                 295                 300                 


Glu Leu Asn Met Arg Arg Asp Val Lys Glu Ile Tyr Ser His Met Thr 
305                 310                 315                 320 


Cys Ala Thr Asp Thr Gln Asn Val Lys Phe Val Phe Asp Ala Val Thr 
                325                 330                 335     


Asp Ile Ile Ile Lys Glu Asn Leu Lys Asp Cys Gly Leu Phe 
            340                 345                 350 


<210> 29
<211> 4337
<212> DNA
<213> Homo sapiens

<400> 29
cgtcatgtta gggtgaagca gaggacctca gtgctgaaca tgctaaggag gttggacaaa       60

atcaggttca gaggtcacaa gagagatgac ttcctcgatc tagcggagtc tccaaatgcc      120

tcggacaccg aatgcagcga cgaaatcccc ctgaaggtac cgcggacctc gccccgggac      180

agcgaggagc tgagggaccc tgctggtcca gggaccctca tcatggccac aggagtccag      240

gactttaacc ggacagagtt tgatcgactg aatgagatca aaggtcacct ggaaattgcc      300

ttattggaaa aacatttctt acaggaggag ctccggaagc tgcgagaaga aaccaacgcg      360

gagatgctgc ggcaggagct ggaccgcgag cggcagcggc ggatggagct ggagcagaag      420

gtgcaggagg tgctgaaggc cagaaccgag gagcagatgg ctcagcagcc cccaaaaggg      480

caggcccagg ccagcaatgg agcagagcgc cggagccagg ggctgtcctc gcgcctgcag      540

aagtggttct acgagcggtt cggggagtac gtggaggact tccggttcca gcccgaggag      600

aacactgtgg agacagagga acccctgagc gcccgcaggt taactgaaaa tatgagacgg      660

ctcaagcgcg gtgccaagcc ggtcactaac tttgtgaaga acctctctgc cttatccgac      720

tggtactccg tctacacgtc tgccattgcc ttcaccgtgt acatgaatgc cgtgtggcat      780

ggctgggcca tcccattgtt cttatttcta gcaattctga ggttatccct caattacctc      840

atcgccaggg ggtggcggat acagtggagc atcgtgcccg aagtgtctga gcccgtggaa      900

cctccaaagg aagacctgac tgtgtctgag aagttccagc tggtgctgga cgtcgcccag      960

aaagcccaga accttttcgg gaagatggct gacatcctgg agaagatcaa gaacttgttc     1020

atgtgggtcc agccggagat cacacagaag ctgtatgtgg cgctctgggc tgccttcctg     1080

gcctcctgct tcttccccta ccgcctggtg gggcttgccg tgggactcta tgctggtatc     1140

aagttcttcc tcattgattt catctttaaa cgctgcccga ggctgcgcgc caagtacgac     1200

acgccctata tcatctggag gagtctcccc accgacccgc agctcaagga gcgctccagc     1260

gccgcagtct cacgcaggct gcagacgacc tcgtcacgga gctacgtacc cagcgcaccg     1320

gccggcctgg gtaaagagga ggacgccggt cgcttccaca gcaccaagaa gggcaatttc     1380

cacgagatct tcaatctgac agaaaacgag cgtccgctgg cggtgtgcga gaatggctgg     1440

cgctgctgcc tcatcaacag ggaccggaag atgcccacgg actacatcag gaacggggtg     1500

ctctacgtca cggagaatta cttgtgcttc gaaagctcca aatctgggtc ctcaaagagg     1560

aacaaagtca tcaagctagt ggacatcacg gacatccaga agtacaaggt cctgtctgtc     1620

ctcccaggct caggcatggg gattgccgtg tcgacgccat ccacccagaa accgctcgtg     1680

tttggtgcca tggtgcacag ggatgaggcc ttcgagacca ttctcagcca gtacatcaag     1740

atcacctcag cggcagcgtc tggcggggac agctagtatt gacttgccca ggacgttgct     1800

ggaattttct ttttcttttt ctttttcttt tttttttttt acgatttggt agtggaaaca     1860

attggacatc ctcatgagct tttgcaataa ttctcctgga cctgtggttc tattgtgttg     1920

acctctgcgt tttatcgacc aagaaggggc cagggctcac agggacgggg gtgcccctct     1980

cccacagggc acgtcaggtg cctctgaggg ccacccgcag actgggggag ggggcagagg     2040

ccctcggggg cccgtggaga agacacacag gacccctggc cctgcccttc tccgttccag     2100

cctggacaga gaaacctctc cagccacccc aagaggttct cgcaaccttg tgtcccgctc     2160

tccagaggcc agaagctcgt ccaccaccaa agccatagct gaagagtgcg gggcccttcc     2220

tcctggggac agaaagatgt cgtcaaggag ggacatgggg gcctttcacc aaccaccgag     2280

aaacgggcct ggcggccctc cttcctctta catgagaccc tcctgtggca tttgcccttg     2340

gtgccgggct ggggccgggc gcagtgaccc tgcctgcgct ccacactcgc tccacgggaa     2400

cagagagggt gagaagggcc cacccctcgc ctgccctcag tgtctttggt ggcaccttcc     2460

ttgctggcct ccagggcgct cagcaccgcg tctgtaaggg cctgcctgct gctctcggcc     2520

tgacacgccg gccaggaggt ctgtagctgg ggaccagtaa gggcacagga tggtgcaggt     2580

aaaagcacat ctttctcaca ctttgctctt tggaaggccc aggagaacat ccgcgaaggc     2640

tgttggaggt gctccgagca ctgtggcatg tctggcacat ggcccccagg ctgcggttgc     2700

ctgggttggt tgggggagga agtggggagg agtgttccgg gaccatggtg gcccaggctg     2760

cagccgcctt tgggccatcc gagaggctct ggcagcccct gtgctttagg gagcaaccgt     2820

gagccgagcc cagaggcctg ggcctgcact gcctgcagcc gacatgcgac agcgttccct     2880

cccccgcgtg cctagccggt gccggtccgg gcacagaccc ccccagcccc cgccctgccc     2940

cagggaagcc tgggcttccc gggaacaagg tggcatttgt ggagggagcg cccgcaggcc     3000

tggtctgctg gggccgcctg cgctgggctg aagggaggga aaggcggctt gggcctcctg     3060

gaaggaggtg gccaccccgc gggcctgcgt gtctgctggg gcggatcccg cagctccctc     3120

agcttgtcct gagtcccttg ggtgtcgttg agattgttgt tttttgaaga aacagaagat     3180

tctatttttt acagcgagca agctggtttt cttatttttg tatccttttt cagatgtaat     3240

ttttatcttt gctccgatcc tcatttgctg gtgtgggtga gggatccggc ggcatgggct     3300

ggtttcaccc ccttcacgag gggccgcaga gtcacacgct ggtgccgggg gtgctttggg     3360

gggagctgcg ccgatcacca gattaagcac atgtcctatc ccaggcggtg gagcggagcc     3420

cccgtggctc tggactgcgc ggacgttggc gtcaggatga ccacacggcg gcctttcccg     3480

aatggggaca gaacccgctc tgagccgtgg gtctggctcc tgtaggggac tggctctctt     3540

ggtgcaccag gggaggggga catatcccag tgaaccccac cttggcgcct gaggcaacac     3600

agggtgggca ctgacccacc cccaggggcg gctgcagagg cagtgcccgc agacaatggc     3660

cacacctctc tccccagggc ccggcagtgc ccaaggatgg gtccggggcc tcggggccaa     3720

tgagcgcctc ttcctaggtg ctgggattca gtccccaaac acagcgggag gggtccctgg     3780

ggcagatggg gctttaccag cgtcgggtgg tttagttcga gtcccttttg tggagaaagg     3840

gagatgaaaa ctgaccacgt gccaggtgtg gccgaagccc ccagggaggg ccacattcgg     3900

ggagcggggg gtcgggggag ggccaccgac tggctctgct gccagcacag gcccctccct     3960

ggaagtcctc gggagcggag cgcggatcgg cacgggctct gggctccccg tggagagaag     4020

ctgtagtttt taccaaattg tgtacatctg ggcagatgtt taatttctgt gactaatcac     4080

tgaactagac gaatgttaaa ttttttatgt ctgaagcctg agtctatttt ggatctgtaa     4140

ataatcattg ccagtgtgac ttttgttcaa caaaaggatt gtactgtatt aagaaccgat     4200

gaaaaaaatt ctcctgtaac atttttttaa gaaaactttg tttgtttaaa gaaaaagtat     4260

tgtataaatt ataattttta tttaaataaa cctaaaatgc tttgtgctaa ggctcaaaaa     4320

aaaaaaaaaa aaaaaaa                                                    4337


<210> 30
<211> 578
<212> PRT
<213> Homo sapiens

<400> 30
Met Leu Arg Arg Leu Asp Lys Ile Arg Phe Arg Gly His Lys Arg Asp 
1               5                   10                  15      


Asp Phe Leu Asp Leu Ala Glu Ser Pro Asn Ala Ser Asp Thr Glu Cys 
            20                  25                  30          


Ser Asp Glu Ile Pro Leu Lys Val Pro Arg Thr Ser Pro Arg Asp Ser 
        35                  40                  45              


Glu Glu Leu Arg Asp Pro Ala Gly Pro Gly Thr Leu Ile Met Ala Thr 
    50                  55                  60                  


Gly Val Gln Asp Phe Asn Arg Thr Glu Phe Asp Arg Leu Asn Glu Ile 
65                  70                  75                  80  


Lys Gly His Leu Glu Ile Ala Leu Leu Glu Lys His Phe Leu Gln Glu 
                85                  90                  95      


Glu Leu Arg Lys Leu Arg Glu Glu Thr Asn Ala Glu Met Leu Arg Gln 
            100                 105                 110         


Glu Leu Asp Arg Glu Arg Gln Arg Arg Met Glu Leu Glu Gln Lys Val 
        115                 120                 125             


Gln Glu Val Leu Lys Ala Arg Thr Glu Glu Gln Met Ala Gln Gln Pro 
    130                 135                 140                 


Pro Lys Gly Gln Ala Gln Ala Ser Asn Gly Ala Glu Arg Arg Ser Gln 
145                 150                 155                 160 


Gly Leu Ser Ser Arg Leu Gln Lys Trp Phe Tyr Glu Arg Phe Gly Glu 
                165                 170                 175     


Tyr Val Glu Asp Phe Arg Phe Gln Pro Glu Glu Asn Thr Val Glu Thr 
            180                 185                 190         


Glu Glu Pro Leu Ser Ala Arg Arg Leu Thr Glu Asn Met Arg Arg Leu 
        195                 200                 205             


Lys Arg Gly Ala Lys Pro Val Thr Asn Phe Val Lys Asn Leu Ser Ala 
    210                 215                 220                 


Leu Ser Asp Trp Tyr Ser Val Tyr Thr Ser Ala Ile Ala Phe Thr Val 
225                 230                 235                 240 


Tyr Met Asn Ala Val Trp His Gly Trp Ala Ile Pro Leu Phe Leu Phe 
                245                 250                 255     


Leu Ala Ile Leu Arg Leu Ser Leu Asn Tyr Leu Ile Ala Arg Gly Trp 
            260                 265                 270         


Arg Ile Gln Trp Ser Ile Val Pro Glu Val Ser Glu Pro Val Glu Pro 
        275                 280                 285             


Pro Lys Glu Asp Leu Thr Val Ser Glu Lys Phe Gln Leu Val Leu Asp 
    290                 295                 300                 


Val Ala Gln Lys Ala Gln Asn Leu Phe Gly Lys Met Ala Asp Ile Leu 
305                 310                 315                 320 


Glu Lys Ile Lys Asn Leu Phe Met Trp Val Gln Pro Glu Ile Thr Gln 
                325                 330                 335     


Lys Leu Tyr Val Ala Leu Trp Ala Ala Phe Leu Ala Ser Cys Phe Phe 
            340                 345                 350         


Pro Tyr Arg Leu Val Gly Leu Ala Val Gly Leu Tyr Ala Gly Ile Lys 
        355                 360                 365             


Phe Phe Leu Ile Asp Phe Ile Phe Lys Arg Cys Pro Arg Leu Arg Ala 
    370                 375                 380                 


Lys Tyr Asp Thr Pro Tyr Ile Ile Trp Arg Ser Leu Pro Thr Asp Pro 
385                 390                 395                 400 


Gln Leu Lys Glu Arg Ser Ser Ala Ala Val Ser Arg Arg Leu Gln Thr 
                405                 410                 415     


Thr Ser Ser Arg Ser Tyr Val Pro Ser Ala Pro Ala Gly Leu Gly Lys 
            420                 425                 430         


Glu Glu Asp Ala Gly Arg Phe His Ser Thr Lys Lys Gly Asn Phe His 
        435                 440                 445             


Glu Ile Phe Asn Leu Thr Glu Asn Glu Arg Pro Leu Ala Val Cys Glu 
    450                 455                 460                 


Asn Gly Trp Arg Cys Cys Leu Ile Asn Arg Asp Arg Lys Met Pro Thr 
465                 470                 475                 480 


Asp Tyr Ile Arg Asn Gly Val Leu Tyr Val Thr Glu Asn Tyr Leu Cys 
                485                 490                 495     


Phe Glu Ser Ser Lys Ser Gly Ser Ser Lys Arg Asn Lys Val Ile Lys 
            500                 505                 510         


Leu Val Asp Ile Thr Asp Ile Gln Lys Tyr Lys Val Leu Ser Val Leu 
        515                 520                 525             


Pro Gly Ser Gly Met Gly Ile Ala Val Ser Thr Pro Ser Thr Gln Lys 
    530                 535                 540                 


Pro Leu Val Phe Gly Ala Met Val His Arg Asp Glu Ala Phe Glu Thr 
545                 550                 555                 560 


Ile Leu Ser Gln Tyr Ile Lys Ile Thr Ser Ala Ala Ala Ser Gly Gly 
                565                 570                 575     


Asp Ser 
        


<210> 31
<211> 2005
<212> DNA
<213> Homo sapiens

<400> 31
tttcctctca gggggcagca ggaagtgagg agaaagggct gggatgggag gcgggagcgg       60

atgggaggga atggggttta tcaagtcctc ggcgagctgc ccaacgggca gcagctggcg      120

caagtagcct agctggagag gctcacccca ggaaggaggg aggccaccga cctactgggc      180

cgacggactc ccacacagtt cctgagctgg tgccaggcag gtgacacctc ctgcagcccc      240

cagcatgcgg gcaggcccag gccccaccgt tacattggcc ctggtgctgg cggtgtcatg      300

ggccatggag ctcaagccca cagcaccacc catcttcact ggccggccct ttgtggtagc      360

gtgggacgtg cccacacagg actgtggccc acgcctcaag gtgccactgg acctgaatgc      420

ctttgatgtg caggcctcac ctaatgaggg ttttgtgaac cagaatatta ccatcttcta      480

ccgcgaccgt ctaggcctgt atccacgctt cgattctgcc ggaaggtctg tgcatggtgg      540

tgtgccacag aatgtcagcc tttgggcaca ccggaagatg ctgcagaaac gtgtggagca      600

ctacattcgg acacaggagt ctgcggggct ggcggtcatc gactgggagg actggcgacc      660

tgtgtgggtg cgcaactggc aggacaaaga tgtgtatcgc cggttatcac gccagctagt      720

ggccagtcgt caccctgact ggcctccaga ccgcatagtc aaacaggcac aatatgagtt      780

tgagttcgca gcacagcagt tcatgctgga gacactgcgt tatgtcaagg cagtgcggcc      840

ccggcacctc tggggcttct acctctttcc tgactgctac aatcatgatt atgtgcagaa      900

ctgggagagc tacacaggcc gctgccctga tgttgaggtg gcccgcaatg accagctggc      960

ctggctgtgg gctgagagca cggccctctt cccgtctgtc tacctggacg agacacttgc     1020

ttcctcccgc catggccgca actttgtgag cttccgtgtt caggaggccc ttcgtgtggc     1080

tcgcacccac catgccaacc atgcactccc agtctacgtc ttcacacgac ccacctacag     1140

ccgcaggctc acggggctta gtgagatgga cctcatctct accattggcg agagtgcggc     1200

cctgggcgca gctggtgtca tcctctgggg tgacgcgggg tacaccacaa gcacggagac     1260

ctgccagtac ctcaaagatt acctgacacg gctgctggtc ccctacgtgg tcaatgtgtc     1320

ctgggccacc caatattgca gccgggccca gtgccatggc catgggcgct gtgtgcgccg     1380

caaccccagt gccagtacct tcctgcatct cagcaccaac agtttccgcc tagtgcctgg     1440

ccatgcacct ggtgaacccc agctgcgacc tgtgggggag ctcagttggg ccgacattga     1500

ccacctgcag acacacttcc gctgccagtg ctacttgggc tggagtggtg agcaatgcca     1560

gtgggaccat aggcaggcag ctggaggtgc cagcgaggcc tgggctgggt cccacctcac     1620

cagtctgctg gctctggcag ccctggcctt tacctggacc ttgtaggggt ctcctgccta     1680

gctgcctagc aagctggcct ctaccacaag ggctctctta ggcatgtagg accctgcagg     1740

gggtggacaa actggagtct ggagtgggca gagcccccag gaagcccagg agggcatcca     1800

taccagctcg cacccccctg ttctaagggg gaggggaagt ccctgggagg ccccttctct     1860

ccctgccaga ggggaaggag ggtacagctg ggctggggag gacctgaccc tactcccttg     1920

ccctagatag tttattatta ttattatttt ggggtctctt ttgtaaatta aacataaaac     1980

aattgcttct ctgcttggat tttgt                                           2005


<210> 32
<211> 473
<212> PRT
<213> Homo sapiens

<400> 32
Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
1               5                   10                  15      


Val Ser Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
        35                  40                  45              


Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala 
    50                  55                  60                  


Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg 
65                  70                  75                  80  


Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ser Ala Gly Arg Ser Val 
                85                  90                  95      


His Gly Gly Val Pro Gln Asn Val Ser Leu Trp Ala His Arg Lys Met 
            100                 105                 110         


Leu Gln Lys Arg Val Glu His Tyr Ile Arg Thr Gln Glu Ser Ala Gly 
        115                 120                 125             


Leu Ala Val Ile Asp Trp Glu Asp Trp Arg Pro Val Trp Val Arg Asn 
    130                 135                 140                 


Trp Gln Asp Lys Asp Val Tyr Arg Arg Leu Ser Arg Gln Leu Val Ala 
145                 150                 155                 160 


Ser Arg His Pro Asp Trp Pro Pro Asp Arg Ile Val Lys Gln Ala Gln 
                165                 170                 175     


Tyr Glu Phe Glu Phe Ala Ala Gln Gln Phe Met Leu Glu Thr Leu Arg 
            180                 185                 190         


Tyr Val Lys Ala Val Arg Pro Arg His Leu Trp Gly Phe Tyr Leu Phe 
        195                 200                 205             


Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Glu Ser Tyr Thr 
    210                 215                 220                 


Gly Arg Cys Pro Asp Val Glu Val Ala Arg Asn Asp Gln Leu Ala Trp 
225                 230                 235                 240 


Leu Trp Ala Glu Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Glu 
                245                 250                 255     


Thr Leu Ala Ser Ser Arg His Gly Arg Asn Phe Val Ser Phe Arg Val 
            260                 265                 270         


Gln Glu Ala Leu Arg Val Ala Arg Thr His His Ala Asn His Ala Leu 
        275                 280                 285             


Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Ser Arg Arg Leu Thr Gly 
    290                 295                 300                 


Leu Ser Glu Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu 
305                 310                 315                 320 


Gly Ala Ala Gly Val Ile Leu Trp Gly Asp Ala Gly Tyr Thr Thr Ser 
                325                 330                 335     


Thr Glu Thr Cys Gln Tyr Leu Lys Asp Tyr Leu Thr Arg Leu Leu Val 
            340                 345                 350         


Pro Tyr Val Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Arg Ala 
        355                 360                 365             


Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser 
    370                 375                 380                 


Thr Phe Leu His Leu Ser Thr Asn Ser Phe Arg Leu Val Pro Gly His 
385                 390                 395                 400 


Ala Pro Gly Glu Pro Gln Leu Arg Pro Val Gly Glu Leu Ser Trp Ala 
                405                 410                 415     


Asp Ile Asp His Leu Gln Thr His Phe Arg Cys Gln Cys Tyr Leu Gly 
            420                 425                 430         


Trp Ser Gly Glu Gln Cys Gln Trp Asp His Arg Gln Ala Ala Gly Gly 
        435                 440                 445             


Ala Ser Glu Ala Trp Ala Gly Ser His Leu Thr Ser Leu Leu Ala Leu 
    450                 455                 460                 


Ala Ala Leu Ala Phe Thr Trp Thr Leu 
465                 470             


<210> 33
<211> 1629
<212> DNA
<213> Homo sapiens

<400> 33
acacatcagg ggcttgctct tgcaaaacca aaccacaaga cagacttgca aaagaaggca       60

tgcacagctc agcactgctc tgttgcctgg tcctcctgac tggggtgagg gccagcccag      120

gccagggcac ccagtctgag aacagctgca cccacttccc aggcaacctg cctaacatgc      180

ttcgagatct ccgagatgcc ttcagcagag tgaagacttt ctttcaaatg aaggatcagc      240

tggacaactt gttgttaaag gagtccttgc tggaggactt taagggttac ctgggttgcc      300

aagccttgtc tgagatgatc cagttttacc tggaggaggt gatgccccaa gctgagaacc      360

aagacccaga catcaaggcg catgtgaact ccctggggga gaacctgaag accctcaggc      420

tgaggctacg gcgctgtcat cgatttcttc cctgtgaaaa caagagcaag gccgtggagc      480

aggtgaagaa tgcctttaat aagctccaag agaaaggcat ctacaaagcc atgagtgagt      540

ttgacatctt catcaactac atagaagcct acatgacaat gaagatacga aactgagaca      600

tcagggtggc gactctatag actctaggac ataaattaga ggtctccaaa atcggatctg      660

gggctctggg atagctgacc cagccccttg agaaacctta ttgtacctct cttatagaat      720

atttattacc tctgatacct caacccccat ttctatttat ttactgagct tctctgtgaa      780

cgatttagaa agaagcccaa tattataatt tttttcaata tttattattt tcacctgttt      840

ttaagctgtt tccatagggt gacacactat ggtatttgag tgttttaaga taaattataa      900

gttacataag ggaggaaaaa aaatgttctt tggggagcca acagaagctt ccattccaag      960

cctgaccacg ctttctagct gttgagctgt tttccctgac ctccctctaa tttatcttgt     1020

ctctgggctt ggggcttcct aactgctaca aatactctta ggaagagaaa ccagggagcc     1080

cctttgatga ttaattcacc ttccagtgtc tcggagggat tcccctaacc tcattcccca     1140

accacttcat tcttgaaagc tgtggccagc ttgttattta taacaaccta aatttggttc     1200

taggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggct gaggcgggtg     1260

gatcacttga ggtcaggagt tcctaaccag cctggtcaac atggtgaaac cccgtctcta     1320

ctaaaaatac aaaaattagc cgggcatggt ggcgcgcacc tgtaatccca gctacttggg     1380

aggctgaggc aagagaattg cttgaaccca ggagatggaa gttgcagtga gctgatatca     1440

tgcccctgta ctccagcctg ggtgacagag caagactctg tctcaaaaaa taaaaataaa     1500

aataaatttg gttctaatag aactcagttt taactagaat ttattcaatt cctctgggaa     1560

tgttacattg tttgtctgtc ttcatagcag attttaattt tgaataaata aatgtatctt     1620

attcacatc                                                             1629


<210> 34
<211> 178
<212> PRT
<213> Homo sapiens

<400> 34
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 35
<211> 2970
<212> DNA
<213> Homo sapiens

<400> 35
agtgacgcca gggggcgggg ccagcggcgc ggtcgggtga gaggccgcgg cggcaggtcc       60

acctgggctt gcgaaggcac agattccccg tccacagctc acgaccagat gcaccagcag      120

gagtccacat cgaggacgtc ctccgggcac tcccacgacc agtgaccagg agttaaactt      180

tgggatgtgc ccgtgatgtt ggaccacaag gacttagagg ccgaaatcca ccccttgaaa      240

aatgaagaaa gaaaatcgca ggaaaatctg ggaaatccat caaaaaatga ggataacgtg      300

aaaagcgcgc ctccacagtc ccggctctcc cggtgccgag cggcggcgtt ttttctttca      360

ttgtttctct gcctttttgt ggtgttcgtc gtctcattcg tcatcccgtg tccagaccgg      420

ccggcgtcac agcgaatgtg gaggatagac tacagtgccg ctgttatcta tgactttctg      480

gctgtggatg atataaacgg ggacaggatc caagatgttc tttttcttta taaaaacacc      540

aacagcagca acaatttcag ccgatcctgt gtggacgaag gcttttcctc tccctgcacc      600

tttgcagctg ctgtgtcggg ggccaacggc agcacgctct gggagagacc tgtggcccaa      660

gacgtggccc tcgtggagtg tgctgtgccc cagccaagag gcagtgaggc accttctgcc      720

tgcatcctgg tgggcagacc cagttctttc attgcagtca acttgttcac aggggaaacc      780

ctgtggaacc acagcagcag cttcagcggg aatgcgtcca tcctgagccc tctgctgcag      840

gtgcctgatg tggacggcga tggggcccca gacctgctgg ttctcaccca ggagcgggag      900

gaggttagtg gccacctcta ctccggcagc accgggcacc agattggcct cagaggcagc      960

cttggtgtgg acggggaaag tggcttcctc cttcacgtca ccaggacagg tgcccactac     1020

atcctctttc cctgcgcaag ctccctctgc ggctgctctg tgaagggtct ctacgagaag     1080

gtgaccggga gcggcggccc gttcaagagt gacccgcact gggagagcat gctcaatgcc     1140

accacccgca ggatgctttc ccacagctct ggagcagtgc gctacctgat gcatgtccca     1200

gggaacgccg gtgcagatgt gcttcttgtg ggctcagagg ccttcgtgct gctggacggg     1260

caggagctga cgcctcgctg gacacccaag gcagcccatg tcctgagaaa acccatcttc     1320

ggccgctaca aaccagacac cttggctgta gccgttgaaa acggaactgg caccgacaga     1380

cagatcctgt ttctggacct tggcactgga gccgtcctgt gtagcctagc cctcccgagc     1440

ctccctgggg gtccactgtc cgccagcctg ccgaccgcag accaccgctc agccttcttc     1500

ttctggggcc tccacgagct ggggagcacc agcgagacgg agaccgggga ggcccggcac     1560

agcctgtaca tgttccaccc caccctgccg cgcgtgctgc tggagctggc caatgtctct     1620

acccacattg tcgcctttga cgccgtcctg tttgagccaa gccgccacgc cgcctacatc     1680

cttctgacag gcccggcaga ctcagaggca cccggcctgg tctctgtgat caagcacaag     1740

gtgcgggacc ttgtcccaag cagcagggtg gtccgcctgg gtgagggtgg gccagacagt     1800

gaccaagcca tcagggaccg gttctcccgg ctgcggtacc agagtgaggc gtagaggcac     1860

gccagccaga gcctgtggag agactccgcc tgctgacact aaacgtcctg ggaagtgggc     1920

ccttccctgg gtctctgcac tgactccccc actcctgacc ctggtgatgg tcgccactgg     1980

gcagcagcag ccttaccagt cctccatgat cacacccagg gacctgcatg ggtgagggga     2040

caccctgggc ctctctcccg cccagcatcc tccctgagtc cccacacagg gcctcactct     2100

gcaccccacc agggtcccgc tcacaccagg cagccttcat agtggtctcc ctggccacct     2160

tgggcagagc tgggtcatgc agcaccccat ccttacccgg tgccctctcc ttgccagctt     2220

ctccccaggc cagagcggcc atcgcgtaga aagaaccagg gtgtccccgg gacaggccgt     2280

cccccacccc atcctgtaga agtccattcc ccttttccct cctgtgctct gtcccccaag     2340

gagtcatgga actcagggta ctgggcctca acgggaacct gagacagctc cagcttcgca     2400

gcccttcccg gagctacagg gggatcctct agcatggggg gtgtgacttg gttcctttga     2460

ccaggtcctg tgaggaagcc tggagcaagg gtctccccca gcaggatggg tggggcctgc     2520

tctggagctg agcccgtggc cgctcacagg tgtccttagt ggtgttgcag ctgtctactg     2580

gctgcatgtg ctgtgaatat cccaaggaac tggctgtgga atgcgtgttt gggtcagtct     2640

gtgccctctc agtagacact ggagctgctc tgtccctgaa gaggccccgt gccccaggca     2700

tggcaagcgc ctgcctctcc ccttccggtg ctcacacgcc cacgccgtgc cacccgatgc     2760

aggactcacc tctgtgcctt gctgctcctg aggcccaagg gcagccatgg tgctctgtac     2820

tgctcgggcc gcccaggtca cagagcctga gcttcgtagc caaagcagcc tgatgaccca     2880

cccaccaagg aagaaagcag aataaacatt tttgcactgc ctgaaaaacc ccggtggtca     2940

ggcgtgagcc taaaaaaaaa aaaaaaaaaa                                      2970


<210> 36
<211> 552
<212> PRT
<213> Homo sapiens

<400> 36
Met Leu Asp His Lys Asp Leu Glu Ala Glu Ile His Pro Leu Lys Asn 
1               5                   10                  15      


Glu Glu Arg Lys Ser Gln Glu Asn Leu Gly Asn Pro Ser Lys Asn Glu 
            20                  25                  30          


Asp Asn Val Lys Ser Ala Pro Pro Gln Ser Arg Leu Ser Arg Cys Arg 
        35                  40                  45              


Ala Ala Ala Phe Phe Leu Ser Leu Phe Leu Cys Leu Phe Val Val Phe 
    50                  55                  60                  


Val Val Ser Phe Val Ile Pro Cys Pro Asp Arg Pro Ala Ser Gln Arg 
65                  70                  75                  80  


Met Trp Arg Ile Asp Tyr Ser Ala Ala Val Ile Tyr Asp Phe Leu Ala 
                85                  90                  95      


Val Asp Asp Ile Asn Gly Asp Arg Ile Gln Asp Val Leu Phe Leu Tyr 
            100                 105                 110         


Lys Asn Thr Asn Ser Ser Asn Asn Phe Ser Arg Ser Cys Val Asp Glu 
        115                 120                 125             


Gly Phe Ser Ser Pro Cys Thr Phe Ala Ala Ala Val Ser Gly Ala Asn 
    130                 135                 140                 


Gly Ser Thr Leu Trp Glu Arg Pro Val Ala Gln Asp Val Ala Leu Val 
145                 150                 155                 160 


Glu Cys Ala Val Pro Gln Pro Arg Gly Ser Glu Ala Pro Ser Ala Cys 
                165                 170                 175     


Ile Leu Val Gly Arg Pro Ser Ser Phe Ile Ala Val Asn Leu Phe Thr 
            180                 185                 190         


Gly Glu Thr Leu Trp Asn His Ser Ser Ser Phe Ser Gly Asn Ala Ser 
        195                 200                 205             


Ile Leu Ser Pro Leu Leu Gln Val Pro Asp Val Asp Gly Asp Gly Ala 
    210                 215                 220                 


Pro Asp Leu Leu Val Leu Thr Gln Glu Arg Glu Glu Val Ser Gly His 
225                 230                 235                 240 


Leu Tyr Ser Gly Ser Thr Gly His Gln Ile Gly Leu Arg Gly Ser Leu 
                245                 250                 255     


Gly Val Asp Gly Glu Ser Gly Phe Leu Leu His Val Thr Arg Thr Gly 
            260                 265                 270         


Ala His Tyr Ile Leu Phe Pro Cys Ala Ser Ser Leu Cys Gly Cys Ser 
        275                 280                 285             


Val Lys Gly Leu Tyr Glu Lys Val Thr Gly Ser Gly Gly Pro Phe Lys 
    290                 295                 300                 


Ser Asp Pro His Trp Glu Ser Met Leu Asn Ala Thr Thr Arg Arg Met 
305                 310                 315                 320 


Leu Ser His Ser Ser Gly Ala Val Arg Tyr Leu Met His Val Pro Gly 
                325                 330                 335     


Asn Ala Gly Ala Asp Val Leu Leu Val Gly Ser Glu Ala Phe Val Leu 
            340                 345                 350         


Leu Asp Gly Gln Glu Leu Thr Pro Arg Trp Thr Pro Lys Ala Ala His 
        355                 360                 365             


Val Leu Arg Lys Pro Ile Phe Gly Arg Tyr Lys Pro Asp Thr Leu Ala 
    370                 375                 380                 


Val Ala Val Glu Asn Gly Thr Gly Thr Asp Arg Gln Ile Leu Phe Leu 
385                 390                 395                 400 


Asp Leu Gly Thr Gly Ala Val Leu Cys Ser Leu Ala Leu Pro Ser Leu 
                405                 410                 415     


Pro Gly Gly Pro Leu Ser Ala Ser Leu Pro Thr Ala Asp His Arg Ser 
            420                 425                 430         


Ala Phe Phe Phe Trp Gly Leu His Glu Leu Gly Ser Thr Ser Glu Thr 
        435                 440                 445             


Glu Thr Gly Glu Ala Arg His Ser Leu Tyr Met Phe His Pro Thr Leu 
    450                 455                 460                 


Pro Arg Val Leu Leu Glu Leu Ala Asn Val Ser Thr His Ile Val Ala 
465                 470                 475                 480 


Phe Asp Ala Val Leu Phe Glu Pro Ser Arg His Ala Ala Tyr Ile Leu 
                485                 490                 495     


Leu Thr Gly Pro Ala Asp Ser Glu Ala Pro Gly Leu Val Ser Val Ile 
            500                 505                 510         


Lys His Lys Val Arg Asp Leu Val Pro Ser Ser Arg Val Val Arg Leu 
        515                 520                 525             


Gly Glu Gly Gly Pro Asp Ser Asp Gln Ala Ile Arg Asp Arg Phe Ser 
    530                 535                 540                 


Arg Leu Arg Tyr Gln Ser Glu Ala 
545                 550         


<210> 37
<211> 3675
<212> DNA
<213> Homo sapiens

<400> 37
tagacctcag cttcctctgt caccatggtg ccggctcggc tgggcccggc ggtcgccatg       60

gtaactgggg cgggtcgcag ggtcctggca ggctgggcgc atgcgcgcgg ggactacaag      120

ccgcgccgcg ctgccgctgg cccctcagca accctcgaca tggcgctgag gcggccaccg      180

cgactccggc tctgcgctcg gctgcctgac ttcttcctgc tgctgctttt caggggctgc      240

ctgatagggg ctgtaaatct caaatccagc aatcgaaccc cagtggtaca ggaatttgaa      300

agtgtggaac tgtcttgcat cattacggat tcgcagacaa gtgaccccag gatcgagtgg      360

aagaaaattc aagatgaaca aaccacatat gtgttttttg acaacaaaat tcagggagac      420

ttggcgggtc gtgcagaaat actggggaag acatccctga agatctggaa tgtgacacgg      480

agagactcag ccctttatcg ctgtgaggtc gttgctcgaa atgaccgcaa ggaaattgat      540

gagattgtga tcgagttaac tgtgcaagtg aagccagtga cccctgtctg tagagtgccg      600

aaggctgtac cagtaggcaa gatggcaaca ctgcactgcc aggagagtga gggccacccc      660

cggcctcact acagctggta tcgcaatgat gtaccactgc ccacggattc cagagccaat      720

cccagatttc gcaattcttc tttccactta aactctgaaa caggcacttt ggtgttcact      780

gctgttcaca aggacgactc tgggcagtac tactgcattg cttccaatga cgcaggctca      840

gccaggtgtg aggagcagga gatggaagtc tatgacctga acattggcgg aattattggg      900

ggggttctgg ttgtccttgc tgtactggcc ctgatcacgt tgggcatctg ctgtgcatac      960

agacgtggct acttcatcaa caataaacag gatggagaaa gttacaagaa cccagggaaa     1020

ccagatggag ttaactacat ccgcactgac gaggagggcg acttcagaca caagtcatcg     1080

tttgtgatct gagacccgcg gtgtggctga gagcgcacag agcgcacgtg cacatacctc     1140

tgctagaaac tcctgtcaag gcagcgagag ctgatgcact cggacagagc tagacactca     1200

ttcagaagct tttcgttttg gccaaagttg accactactc ttcttactct aacaagccac     1260

atgaatagaa gaattttcct caagatggac ccggtaaata taaccacaag gaagcgaaac     1320

tgggtgcgtt cactgagttg ggttcctaat ctgtttctgg cctgattccc gcatgagtat     1380

tagggtgatc ttaaagagtt tgctcacgta aacgcccgtg ctgggccctg tgaagccagc     1440

atgttcacca ctggtcgttc agcagccacg acagcaccat gtgagatggc gaggtggctg     1500

gacagcacca gcagcgcatc ccggcgggaa cccagaaaag gcttcttaca cagcagcctt     1560

acttcatcgg cccacagaca ccaccgcagt ttcttcttaa aggctctgct gatcggtgtt     1620

gcagtgtcca ttgtggagaa gctttttgga tcagcatttt gtaaaaacaa ccaaaatcag     1680

gaaggtaaat tggttgctgg aagagggatc ttgcctgagg aaccctgctt gtccaacagg     1740

gtgtcaggat ttaaggaaaa ccttcgtctt aggctaagtc tgaaatggta ctgaaatatg     1800

cttttctatg ggtcttgttt attttataaa attttacatc taaatttttg ctaaggatgt     1860

attttgatta ttgaaaagaa aatttctatt taaactgtaa atatattgtc atacaatgtt     1920

aaataaccta tttttttaaa aaagttcaac ttaaggtaga agttccaagc tactagtgtt     1980

aaattggaaa atatcaataa ttaagagtat tttacccaag gaatcctctc atggaagttt     2040

actgtgatgt tccttttctc acacaagttt tagccttttt cacaagggaa ctcatactgt     2100

ctacacatca gaccatagtt gcttaggaaa cctttaaaaa ttccagttaa gcaatgttga     2160

aatcagtttg catctcttca aaagaaacct ctcaggttag ctttgaactg cctcttcctg     2220

agatgactag gacagtctgt acccagaggc cacccagaag ccctcagatg tacatacaca     2280

gatgccagtc agctcctggg gttgcgccag gcgcccccgc tctagctcac tgttgcctcg     2340

ctgtctgcca ggaggccctg ccatccttgg gccctggcag tggctgtgtc ccagtgagct     2400

ttactcacgt ggcccttgct tcatccagca cagctctcag gtgggcactg cagggacact     2460

ggtgtcttcc atgtagcgtc ccagctttgg gctcctgtaa cagacctctt tttggttatg     2520

gatggctcac aaaatagggc ccccaatgct attttttttt tttaagtttg tttaattatt     2580

tgttaagatt gtctaaggcc aaaggcaatt gcgaaatcaa gtctgtcaag tacaataaca     2640

tttttaaaag aaaatggatc ccactgttcc tctttgccac agagaaagca cccagacgcc     2700

acaggctctg tcgcatttca aaacaaacca tgatggagtg gcggccagtc cagcctttta     2760

aagaacgtca ggtggagcag ccaggtgaaa ggcctggcgg ggaggaaagt gaaacgcctg     2820

aatcaaaagc agttttctaa ttttgacttt aaatttttca tccgccggag acactgctcc     2880

catttgtggg gggacattag caacatcact cagaagcctg tgttcttcaa gagcaggtgt     2940

tctcagcctc acatgccctg ccgtgctgga ctcaggactg aagtgctgta aagcaaggag     3000

ctgctgagaa ggagcactcc actgtgtgcc tggagaatgg ctctcactac tcaccttgtc     3060

tttcagcttc cagtgtcttg ggttttttat actttgacag ctttttttta attgcataca     3120

tgagactgtg ttgacttttt ttagttatgt gaaacacttt gccgcaggcc gcctggcaga     3180

ggcaggaaat gctccagcag tggctcagtg ctccctggtg tctgctgcat ggcatcctgg     3240

atgcttagca tgcaagttcc ctccatcatt gccaccttgg tagagaggga tggctcccca     3300

ccctcagcgt tggggattca cgctccagcc tccttcttgg ttgtcatagt gatagggtag     3360

ccttattgcc ccctcttctt ataccctaaa accttctaca ctagtgccat gggaaccagg     3420

tctgaaaaag tagagagaag tgaaagtaga gtctgggaag tagctgccta taactgagac     3480

tagacggaaa aggaatactc gtgtatttta agatatgaat gtgactcaag actcgaggcc     3540

gatacgaggc tgtgattctg cctttggatg gatgttgctg tacacagatg ctacagactt     3600

gtactaacac accgtaattt ggcatttgtt taacctcatt tataaaagct tcaaaaaaac     3660

ccaaaaaaac ccaaa                                                      3675


<210> 38
<211> 355
<212> PRT
<213> Homo sapiens

<400> 38
Met Val Pro Ala Arg Leu Gly Pro Ala Val Ala Met Val Thr Gly Ala 
1               5                   10                  15      


Gly Arg Arg Val Leu Ala Gly Trp Ala His Ala Arg Gly Asp Tyr Lys 
            20                  25                  30          


Pro Arg Arg Ala Ala Ala Gly Pro Ser Ala Thr Leu Asp Met Ala Leu 
        35                  40                  45              


Arg Arg Pro Pro Arg Leu Arg Leu Cys Ala Arg Leu Pro Asp Phe Phe 
    50                  55                  60                  


Leu Leu Leu Leu Phe Arg Gly Cys Leu Ile Gly Ala Val Asn Leu Lys 
65                  70                  75                  80  


Ser Ser Asn Arg Thr Pro Val Val Gln Glu Phe Glu Ser Val Glu Leu 
                85                  90                  95      


Ser Cys Ile Ile Thr Asp Ser Gln Thr Ser Asp Pro Arg Ile Glu Trp 
            100                 105                 110         


Lys Lys Ile Gln Asp Glu Gln Thr Thr Tyr Val Phe Phe Asp Asn Lys 
        115                 120                 125             


Ile Gln Gly Asp Leu Ala Gly Arg Ala Glu Ile Leu Gly Lys Thr Ser 
    130                 135                 140                 


Leu Lys Ile Trp Asn Val Thr Arg Arg Asp Ser Ala Leu Tyr Arg Cys 
145                 150                 155                 160 


Glu Val Val Ala Arg Asn Asp Arg Lys Glu Ile Asp Glu Ile Val Ile 
                165                 170                 175     


Glu Leu Thr Val Gln Val Lys Pro Val Thr Pro Val Cys Arg Val Pro 
            180                 185                 190         


Lys Ala Val Pro Val Gly Lys Met Ala Thr Leu His Cys Gln Glu Ser 
        195                 200                 205             


Glu Gly His Pro Arg Pro His Tyr Ser Trp Tyr Arg Asn Asp Val Pro 
    210                 215                 220                 


Leu Pro Thr Asp Ser Arg Ala Asn Pro Arg Phe Arg Asn Ser Ser Phe 
225                 230                 235                 240 


His Leu Asn Ser Glu Thr Gly Thr Leu Val Phe Thr Ala Val His Lys 
                245                 250                 255     


Asp Asp Ser Gly Gln Tyr Tyr Cys Ile Ala Ser Asn Asp Ala Gly Ser 
            260                 265                 270         


Ala Arg Cys Glu Glu Gln Glu Met Glu Val Tyr Asp Leu Asn Ile Gly 
        275                 280                 285             


Gly Ile Ile Gly Gly Val Leu Val Val Leu Ala Val Leu Ala Leu Ile 
    290                 295                 300                 


Thr Leu Gly Ile Cys Cys Ala Tyr Arg Arg Gly Tyr Phe Ile Asn Asn 
305                 310                 315                 320 


Lys Gln Asp Gly Glu Ser Tyr Lys Asn Pro Gly Lys Pro Asp Gly Val 
                325                 330                 335     


Asn Tyr Ile Arg Thr Asp Glu Glu Gly Asp Phe Arg His Lys Ser Ser 
            340                 345                 350         


Phe Val Ile 
        355 


<210> 39
<211> 2581
<212> DNA
<213> Homo sapiens

<400> 39
agtgagcgac acagagcggg ccgccaccgc cgagcagccc tccggcagtc tccgcgtccg       60

ttaagcccgc gggtcctccg cgaatcggcg gtgggtccgg cagccgaatg cagccccgca      120

gcgagcgccc ggccggcagg acgcagagcc cggagcacgg cagcccgggg cccgggcccg      180

aggcgccgcc gcctccaccg ccgcagccgc cggcccccga ggcagagcgc acgcggcccc      240

ggcaggctcg gcccgcagcc cccatggagg gagccgtgca gctgctgagc cgcgagggcc      300

acagcgtggc ccacaactcc aagcggcact accacgatgc cttcgtggcc atgagccgca      360

tgcgccagcg cggcctcctg tgcgacatcg tcctgcacgt ggctgccaag gagatccgtg      420

cgcacaaagt ggtgctggcc tcctgcagcc cctacttcca cgccatgttc acaaatgaga      480

tgagcgagag ccgccagacc cacgtgacgc tgcacgacat cgaccctcag gccttggacc      540

agctggtgca gtttgcctac acggctgaga ttgtggtggg cgagggcaat gtgcagactc      600

tgctcccagc cgccagtctc ctgcagctga atggcgtccg agacgcttgc tgcaagtttc      660

tactgagtca gctcgacccc tccaactgcc tgggtatccg gggctttgcc gatgcgcact      720

cctgcagcga cctgctcaag gccgcccaca ggtacgtgct gcagcacttc gtggacgtgg      780

ccaagaccga ggagtttatg ctgctgcccc tgaaacaggt tctggaactg gtctctagcg      840

acagcctgaa cgtgccttca gaggaggagg tctaccgagc cgtcctgagc tgggtgaaac      900

acgacgtgga cgcccgcagg cagcatgtcc cacggctcat gaagtgtgtg cggctgccct      960

tgctgagccg cgacttcctg ctgggccacg tggatgccga gagcctggtg aggcaccacc     1020

ctgactgcaa ggacctcctc atcgaggccc tgaagttcca cctgctgcct gagcagaggg     1080

gcgtcctagg caccagccgc acacgtcccc ggcgctgcga gggggccggg cctgtgcttt     1140

ttgctgtggg cggcgggagc ctgtttgcca tccacggaga ctgtgaggcc tacgacacgc     1200

gcaccgaccg ctggcacgtg gtggcctcca tgtccacgcg ccgggcccgg gtgggagtgg     1260

ctgcggtggg gaaccggctc tatgctgtgg gcggctatga tgggacctca gacctggcta     1320

ccgtggagtc ctacgacccc gtgactaaca cgtggcagcc ggaggtgtcc atgggcacaa     1380

ggcgaagctg cctgggtgtg gccgccttgc atggactcct gtactcggcc ggcggctatg     1440

acggggcctc ctgcctgaac agtgctgaac gctacgaccc cctgaccgga acgtggacgt     1500

ccgtcgctgc catgagcacc cggaggcgct atgtgcgagt ggccacgctt gatgggaacc     1560

tgtatgctgt gggcggctac gacagctcct cacacctggc cactgtggag aagtatgagc     1620

cccaggtgaa cgtgtggtcg cccgtggcgt ccatgctgag ccgacgcagc tcagcgggcg     1680

tggccgtgct ggagggtgcc ctgtacgtgg cagggggcaa cgacggcacc agctgcctca     1740

actcggtaga gagatacagt ccaaaggctg gagcctggga aagcgtggcg cccatgaata     1800

tccgcaggag cacgcatgac ctggtggcca tggacggatg gttgtacgcc gtggggggta     1860

acgacggtag ctccagcctc aactccatcg agaagtacaa cccgaggacc aacaagtggg     1920

tggccgcatc ctgcatgttc acccggcgca gcagtgtggg tgtggcggtg ctggagctgc     1980

tcaatttccc gccgccatcc tccccgacgc tgtccgtgtc ctccaccagc ctctgaccca     2040

cctaccacca gaggcctgca gcctcccaca tgccttaagg ggaccgtggc ccccaccagg     2100

gacgtcctgc gccatccgtt cacgtctctg catccattcc ttcatgtctt tatttagttg     2160

tttatttatt tagttattta tcttatttat tgaggggtga ggagtgccac ggctgcccgt     2220

ttacaccttt agcgtctggt cctcctgcgt gtcctcccct ccactgcctg catggggggc     2280

gcggggagtg accaggcggg ggcctcaccg ccccagggcc gttgcctgct cagaccttgc     2340

aggctgtgga gcaagaggcc ctgggtctct ccaagcagct gcagacccca gctcgaattt     2400

tgcacatggc ggggtcccgg gaagggtggg gagcagttgt ccttcctgtc gtcgtctgcc     2460

gtgtgccatc tttcctggat cttgtagtgg gtgcacacgc gtgcactggg accccacaca     2520

gcaatacgag tccaacttaa taaacacatt tctggggttc ctcaaaaaaa aaaaaaaaaa     2580

a                                                                     2581


<210> 40
<211> 642
<212> PRT
<213> Homo sapiens

<400> 40
Met Gln Pro Arg Ser Glu Arg Pro Ala Gly Arg Thr Gln Ser Pro Glu 
1               5                   10                  15      


His Gly Ser Pro Gly Pro Gly Pro Glu Ala Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Gln Pro Pro Ala Pro Glu Ala Glu Arg Thr Arg Pro Arg Gln Ala Arg 
        35                  40                  45              


Pro Ala Ala Pro Met Glu Gly Ala Val Gln Leu Leu Ser Arg Glu Gly 
    50                  55                  60                  


His Ser Val Ala His Asn Ser Lys Arg His Tyr His Asp Ala Phe Val 
65                  70                  75                  80  


Ala Met Ser Arg Met Arg Gln Arg Gly Leu Leu Cys Asp Ile Val Leu 
                85                  90                  95      


His Val Ala Ala Lys Glu Ile Arg Ala His Lys Val Val Leu Ala Ser 
            100                 105                 110         


Cys Ser Pro Tyr Phe His Ala Met Phe Thr Asn Glu Met Ser Glu Ser 
        115                 120                 125             


Arg Gln Thr His Val Thr Leu His Asp Ile Asp Pro Gln Ala Leu Asp 
    130                 135                 140                 


Gln Leu Val Gln Phe Ala Tyr Thr Ala Glu Ile Val Val Gly Glu Gly 
145                 150                 155                 160 


Asn Val Gln Thr Leu Leu Pro Ala Ala Ser Leu Leu Gln Leu Asn Gly 
                165                 170                 175     


Val Arg Asp Ala Cys Cys Lys Phe Leu Leu Ser Gln Leu Asp Pro Ser 
            180                 185                 190         


Asn Cys Leu Gly Ile Arg Gly Phe Ala Asp Ala His Ser Cys Ser Asp 
        195                 200                 205             


Leu Leu Lys Ala Ala His Arg Tyr Val Leu Gln His Phe Val Asp Val 
    210                 215                 220                 


Ala Lys Thr Glu Glu Phe Met Leu Leu Pro Leu Lys Gln Val Leu Glu 
225                 230                 235                 240 


Leu Val Ser Ser Asp Ser Leu Asn Val Pro Ser Glu Glu Glu Val Tyr 
                245                 250                 255     


Arg Ala Val Leu Ser Trp Val Lys His Asp Val Asp Ala Arg Arg Gln 
            260                 265                 270         


His Val Pro Arg Leu Met Lys Cys Val Arg Leu Pro Leu Leu Ser Arg 
        275                 280                 285             


Asp Phe Leu Leu Gly His Val Asp Ala Glu Ser Leu Val Arg His His 
    290                 295                 300                 


Pro Asp Cys Lys Asp Leu Leu Ile Glu Ala Leu Lys Phe His Leu Leu 
305                 310                 315                 320 


Pro Glu Gln Arg Gly Val Leu Gly Thr Ser Arg Thr Arg Pro Arg Arg 
                325                 330                 335     


Cys Glu Gly Ala Gly Pro Val Leu Phe Ala Val Gly Gly Gly Ser Leu 
            340                 345                 350         


Phe Ala Ile His Gly Asp Cys Glu Ala Tyr Asp Thr Arg Thr Asp Arg 
        355                 360                 365             


Trp His Val Val Ala Ser Met Ser Thr Arg Arg Ala Arg Val Gly Val 
    370                 375                 380                 


Ala Ala Val Gly Asn Arg Leu Tyr Ala Val Gly Gly Tyr Asp Gly Thr 
385                 390                 395                 400 


Ser Asp Leu Ala Thr Val Glu Ser Tyr Asp Pro Val Thr Asn Thr Trp 
                405                 410                 415     


Gln Pro Glu Val Ser Met Gly Thr Arg Arg Ser Cys Leu Gly Val Ala 
            420                 425                 430         


Ala Leu His Gly Leu Leu Tyr Ser Ala Gly Gly Tyr Asp Gly Ala Ser 
        435                 440                 445             


Cys Leu Asn Ser Ala Glu Arg Tyr Asp Pro Leu Thr Gly Thr Trp Thr 
    450                 455                 460                 


Ser Val Ala Ala Met Ser Thr Arg Arg Arg Tyr Val Arg Val Ala Thr 
465                 470                 475                 480 


Leu Asp Gly Asn Leu Tyr Ala Val Gly Gly Tyr Asp Ser Ser Ser His 
                485                 490                 495     


Leu Ala Thr Val Glu Lys Tyr Glu Pro Gln Val Asn Val Trp Ser Pro 
            500                 505                 510         


Val Ala Ser Met Leu Ser Arg Arg Ser Ser Ala Gly Val Ala Val Leu 
        515                 520                 525             


Glu Gly Ala Leu Tyr Val Ala Gly Gly Asn Asp Gly Thr Ser Cys Leu 
    530                 535                 540                 


Asn Ser Val Glu Arg Tyr Ser Pro Lys Ala Gly Ala Trp Glu Ser Val 
545                 550                 555                 560 


Ala Pro Met Asn Ile Arg Arg Ser Thr His Asp Leu Val Ala Met Asp 
                565                 570                 575     


Gly Trp Leu Tyr Ala Val Gly Gly Asn Asp Gly Ser Ser Ser Leu Asn 
            580                 585                 590         


Ser Ile Glu Lys Tyr Asn Pro Arg Thr Asn Lys Trp Val Ala Ala Ser 
        595                 600                 605             


Cys Met Phe Thr Arg Arg Ser Ser Val Gly Val Ala Val Leu Glu Leu 
    610                 615                 620                 


Leu Asn Phe Pro Pro Pro Ser Ser Pro Thr Leu Ser Val Ser Ser Thr 
625                 630                 635                 640 


Ser Leu 
        


<210> 41
<211> 1897
<212> DNA
<213> Homo sapiens

<400> 41
actcttcgtc atcacctctc ctattcgcct ggacaagctc atgtttgcag gagcaccatg       60

tcttgctcgt ctcgcgcctc ctcctccagg gctggaggca gcagctcagc cagggtgtct      120

gctggtggaa gcagcttcag cagtggaagc agatgtggtc tggggggcag ctcggcccag      180

ggcttccgag gaggagccag cagctgcagc ctgagtgggg ggtctagcgg tgcttttggg      240

ggcagctttg gagggggctt tggtagctgc tcagtagggg gtggttttgg gggagcttca      300

ggctctggga caggatttgg tgggggttct agctttggcg gggtctctgg atttggcagg      360

ggttctggat tctgtgggag ttctagattc agcagtggtg ctactggagg cttctacagc      420

tatggtggtg gtatgggagg tggtgttggc gatggggggc ttttctctgg aggggaaaag      480

caaaccatgc agaacctcaa tgaccgcttg gccaattacc tagacaaggt cagagccctg      540

gaggaggcta acactgatct ggagaacaaa atcaaggagt ggtatgacaa atatgggcct      600

gggtctggag acggtggatc gggaagagat tatagcaaat actattcaat aattgaagat      660

ctcagaaacc agatcattgc tgccactgtt gaaaatgctg ggatcatttt gcacattgac      720

aatgccagat tggctgctga tgacttcaga ctgaagtatg agaacgagct gtgtctccgg      780

cagagcgtgg aggctgacat caatggcctg cggaaagtcc tggatgacct gactatgacc      840

cgctctgacc tggagatgca gattgagagt ttcaccgagg agctagccta cctgaggaag      900

aaccacgagg aggaaatgaa gaatatgcaa ggaagctctg gaggggaggt gaccgtagaa      960

atgaatgctg cgccagggac cgacctgacc aaattactga atgacatgag ggcgcagtac     1020

gaggagctgg ctgagcaaaa ccgccgagag gctgaggagc ggttcaacaa gcagagcgca     1080

tcactacaag cacaaatctc cactgatgct ggggcagcca cttctgccaa gaatgagata     1140

acagaactaa aacgtaccct gcaagccctg gaaattgagc ttcagtccca actggccatg     1200

aaaagctccc tggagggaac cctggctgac acagaagctg gctacgtggc tcagctgtca     1260

gaaattcaaa cgcagatcag tgccctggag gaggagatct gccagatctg gggtgagact     1320

aaatgccaga acgcagagta caagcaattg ctggacatca agacacgcct ggaggtggag     1380

atcgagacct accgccgcct gctcgatgga gagggaggtg gttctagttt tgcagaattt     1440

ggtggtagaa actcaggatc tgtaaacatg ggatccaggg atctggtatc tggtgactca     1500

agatctggaa gctgttctgg tcaaggacga gattcaagca agactagagt gactaagact     1560

atcgtagagg agttggtgga tggcaaggtt gtctcgtctc aagtcagcag tatttctgag     1620

gtgaaagtta aataaggaac ttccagatca acaaaagtgt ctttcaaaga aaaaaaaatc     1680

aagaaggaca caagcgaaga aatggcatca atctaggcat ctttctggat aatttcagga     1740

aaagcttcag tccagaaatg gatgactagc caacttttct gcatcttctt atttcctcat     1800

tagaatgctc ttgaaatagc tgaattaaca actttgcttt aattgtttct atgcttcaat     1860

aaatttactt ttgcaagtta aaaaaaaaaa aaaaaaa                              1897


<210> 42
<211> 525
<212> PRT
<213> Homo sapiens

<400> 42
Met Ser Cys Ser Ser Arg Ala Ser Ser Ser Arg Ala Gly Gly Ser Ser 
1               5                   10                  15      


Ser Ala Arg Val Ser Ala Gly Gly Ser Ser Phe Ser Ser Gly Ser Arg 
            20                  25                  30          


Cys Gly Leu Gly Gly Ser Ser Ala Gln Gly Phe Arg Gly Gly Ala Ser 
        35                  40                  45              


Ser Cys Ser Leu Ser Gly Gly Ser Ser Gly Ala Phe Gly Gly Ser Phe 
    50                  55                  60                  


Gly Gly Gly Phe Gly Ser Cys Ser Val Gly Gly Gly Phe Gly Gly Ala 
65                  70                  75                  80  


Ser Gly Ser Gly Thr Gly Phe Gly Gly Gly Ser Ser Phe Gly Gly Val 
                85                  90                  95      


Ser Gly Phe Gly Arg Gly Ser Gly Phe Cys Gly Ser Ser Arg Phe Ser 
            100                 105                 110         


Ser Gly Ala Thr Gly Gly Phe Tyr Ser Tyr Gly Gly Gly Met Gly Gly 
        115                 120                 125             


Gly Val Gly Asp Gly Gly Leu Phe Ser Gly Gly Glu Lys Gln Thr Met 
    130                 135                 140                 


Gln Asn Leu Asn Asp Arg Leu Ala Asn Tyr Leu Asp Lys Val Arg Ala 
145                 150                 155                 160 


Leu Glu Glu Ala Asn Thr Asp Leu Glu Asn Lys Ile Lys Glu Trp Tyr 
                165                 170                 175     


Asp Lys Tyr Gly Pro Gly Ser Gly Asp Gly Gly Ser Gly Arg Asp Tyr 
            180                 185                 190         


Ser Lys Tyr Tyr Ser Ile Ile Glu Asp Leu Arg Asn Gln Ile Ile Ala 
        195                 200                 205             


Ala Thr Val Glu Asn Ala Gly Ile Ile Leu His Ile Asp Asn Ala Arg 
    210                 215                 220                 


Leu Ala Ala Asp Asp Phe Arg Leu Lys Tyr Glu Asn Glu Leu Cys Leu 
225                 230                 235                 240 


Arg Gln Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Lys Val Leu Asp 
                245                 250                 255     


Asp Leu Thr Met Thr Arg Ser Asp Leu Glu Met Gln Ile Glu Ser Phe 
            260                 265                 270         


Thr Glu Glu Leu Ala Tyr Leu Arg Lys Asn His Glu Glu Glu Met Lys 
        275                 280                 285             


Asn Met Gln Gly Ser Ser Gly Gly Glu Val Thr Val Glu Met Asn Ala 
    290                 295                 300                 


Ala Pro Gly Thr Asp Leu Thr Lys Leu Leu Asn Asp Met Arg Ala Gln 
305                 310                 315                 320 


Tyr Glu Glu Leu Ala Glu Gln Asn Arg Arg Glu Ala Glu Glu Arg Phe 
                325                 330                 335     


Asn Lys Gln Ser Ala Ser Leu Gln Ala Gln Ile Ser Thr Asp Ala Gly 
            340                 345                 350         


Ala Ala Thr Ser Ala Lys Asn Glu Ile Thr Glu Leu Lys Arg Thr Leu 
        355                 360                 365             


Gln Ala Leu Glu Ile Glu Leu Gln Ser Gln Leu Ala Met Lys Ser Ser 
    370                 375                 380                 


Leu Glu Gly Thr Leu Ala Asp Thr Glu Ala Gly Tyr Val Ala Gln Leu 
385                 390                 395                 400 


Ser Glu Ile Gln Thr Gln Ile Ser Ala Leu Glu Glu Glu Ile Cys Gln 
                405                 410                 415     


Ile Trp Gly Glu Thr Lys Cys Gln Asn Ala Glu Tyr Lys Gln Leu Leu 
            420                 425                 430         


Asp Ile Lys Thr Arg Leu Glu Val Glu Ile Glu Thr Tyr Arg Arg Leu 
        435                 440                 445             


Leu Asp Gly Glu Gly Gly Gly Ser Ser Phe Ala Glu Phe Gly Gly Arg 
    450                 455                 460                 


Asn Ser Gly Ser Val Asn Met Gly Ser Arg Asp Leu Val Ser Gly Asp 
465                 470                 475                 480 


Ser Arg Ser Gly Ser Cys Ser Gly Gln Gly Arg Asp Ser Ser Lys Thr 
                485                 490                 495     


Arg Val Thr Lys Thr Ile Val Glu Glu Leu Val Asp Gly Lys Val Val 
            500                 505                 510         


Ser Ser Gln Val Ser Ser Ile Ser Glu Val Lys Val Lys 
        515                 520                 525 


<210> 43
<211> 1283
<212> DNA
<213> Homo sapiens

<400> 43
attctaaccg caaggagtag cggaggggag gtcgtgatgg cggcgccgga ggcggaggtt       60

ctgtcctcag ccgcagtccc tgatttggag tggtatgaga agtccgaaga aactcacgcc      120

tcccagatag aactacttga gacaagctct acgcaggaac ctctcaacgc ttcggaggcc      180

ttttgcccaa gagactgcat ggtaccagtg gtgtttcctg ggcctgtgag ccaggaaggc      240

tgctgtcagt ttacttgtga acttctaaag catatcatgt atcaacgcca gcagctccct      300

ctgccctatg aacagcttaa gcacttttac cgaaaacctt ctccccaggc agaggagatg      360

ctgaagaaga aacctcgggc caccactgag gtgagcagca ggaaatgcca acaagccctg      420

gcagaactgg agagtgtcct cagccacctg gaggacttct ttgcacggac actagtaccg      480

cgagtgctga ttctccttgg gggcaatgcc ctaagcccca aggagttcta tgaactcgac      540

ttgtctctgc tggcccccta cagcgtggac cagagcctga gcacagcagc ttgtttgcgc      600

cgtctcttcc gagccatatt catggctgat gcctttagcg agcttcaggc tcctccactc      660

atgggcaccg tcgtcatggc acagggacac cgcaactgtg gagaagattg gtttcgaccc      720

aagctcaact atcgagtgcc cagccggggc cataaactga ctgtgaccct gtcatgtggc      780

agaccttcca tccgaaccac ggcttgggaa gactacattt ggttccaggc accagtgaca      840

tttaaaggct tccgcgagtg aatgagtgct tcttaatcct aaaaacacaa tggctgaatt      900

atctttctcc atgtggcgct gaatcaccca tctggtttgg agctagagtt gcttcctggt      960

gagagaggaa gcaactctcc ttctggttgt ctgcctcccc tcagatttcc tgataggctg     1020

atggcatgtg gctgtgactg tgactgtaat cattgctgaa caacatctct ttgaatcaaa     1080

ggttgatttt cccagagggt gctgggtcag gcatttctat taggagttgg aaagcaaaaa     1140

tgggtccata gacactctat ggaggtgtcc ctttctgctc tttgctgtgt cctttcagaa     1200

tttttaccag gaacataatg tggatgtgac ttatgaactt aaatataaaa taaatagatt     1260

cttattatat tttcctgaaa aaa                                             1283


<210> 44
<211> 274
<212> PRT
<213> Homo sapiens

<400> 44
Met Ala Ala Pro Glu Ala Glu Val Leu Ser Ser Ala Ala Val Pro Asp 
1               5                   10                  15      


Leu Glu Trp Tyr Glu Lys Ser Glu Glu Thr His Ala Ser Gln Ile Glu 
            20                  25                  30          


Leu Leu Glu Thr Ser Ser Thr Gln Glu Pro Leu Asn Ala Ser Glu Ala 
        35                  40                  45              


Phe Cys Pro Arg Asp Cys Met Val Pro Val Val Phe Pro Gly Pro Val 
    50                  55                  60                  


Ser Gln Glu Gly Cys Cys Gln Phe Thr Cys Glu Leu Leu Lys His Ile 
65                  70                  75                  80  


Met Tyr Gln Arg Gln Gln Leu Pro Leu Pro Tyr Glu Gln Leu Lys His 
                85                  90                  95      


Phe Tyr Arg Lys Pro Ser Pro Gln Ala Glu Glu Met Leu Lys Lys Lys 
            100                 105                 110         


Pro Arg Ala Thr Thr Glu Val Ser Ser Arg Lys Cys Gln Gln Ala Leu 
        115                 120                 125             


Ala Glu Leu Glu Ser Val Leu Ser His Leu Glu Asp Phe Phe Ala Arg 
    130                 135                 140                 


Thr Leu Val Pro Arg Val Leu Ile Leu Leu Gly Gly Asn Ala Leu Ser 
145                 150                 155                 160 


Pro Lys Glu Phe Tyr Glu Leu Asp Leu Ser Leu Leu Ala Pro Tyr Ser 
                165                 170                 175     


Val Asp Gln Ser Leu Ser Thr Ala Ala Cys Leu Arg Arg Leu Phe Arg 
            180                 185                 190         


Ala Ile Phe Met Ala Asp Ala Phe Ser Glu Leu Gln Ala Pro Pro Leu 
        195                 200                 205             


Met Gly Thr Val Val Met Ala Gln Gly His Arg Asn Cys Gly Glu Asp 
    210                 215                 220                 


Trp Phe Arg Pro Lys Leu Asn Tyr Arg Val Pro Ser Arg Gly His Lys 
225                 230                 235                 240 


Leu Thr Val Thr Leu Ser Cys Gly Arg Pro Ser Ile Arg Thr Thr Ala 
                245                 250                 255     


Trp Glu Asp Tyr Ile Trp Phe Gln Ala Pro Val Thr Phe Lys Gly Phe 
            260                 265                 270         


Arg Glu 
        


<210> 45
<211> 2297
<212> DNA
<213> Homo sapiens

<400> 45
aaccacaaaa cccgccaggc cggtgcggga gctgcggagc atccgctgcg gtcctcgccg       60

agacccccgc gcggattcgc cggtccttcc cgcgggcgcg acagagctgt cctcgcacct      120

ggatggcagc aggggcgccg gggtcctctc gacgccagag agaaatctca tcatctgtgc      180

agccttctta aagcaaacta agaccagagg gaggattatc cttgaccttt gaagaccaaa      240

actaaactga aatttaaaat gttcttcggg ggagaaggga gcttgactta cactttggta      300

ataatttgct tcctgacact aaggctgtct gctagtcaga attgcctcaa aaagagtcta      360

gaagatgttg tcattgacat ccagtcatct ctttctaagg gaatcagagg caatgagccc      420

gtatatactt caactcaaga agactgcatt aattcttgct gttcaacaaa aaacatatca      480

ggggacaaag catgtaactt gatgatcttc gacactcgaa aaacagctag acaacccaac      540

tgctacctat ttttctgtcc caacgaggaa gcctgtccat tgaaaccagc aaaaggactt      600

atgagttaca ggataattac agattttcca tctttgacca gaaatttgcc aagccaagag      660

ttaccccagg aagattctct cttacatggc caattttcac aagcagtcac tcccctagcc      720

catcatcaca cagattattc aaagcccacc gatatctcat ggagagacac actttctcag      780

aagtttggat cctcagatca cttggagaaa ctatttaaga tggatgaagc aagtgcccag      840

ctccttgctt ataaggaaaa aggccattct cagagttcac aattttcctc tgatcaagaa      900

atagctcatc tgctgcctga aaatgtgagt gcgctcccag ctacggtggc agttgcttct      960

ccacatacca cctcggctac tccaaagccc gccacccttc tacccaccaa tgcttcagtg     1020

acaccttctg ggacttccca gccacagctg gccaccacag ctccacctgt aaccactgtc     1080

acttctcagc ctcccacgac cctcatttct acagttttta cacgggctgc ggctacactc     1140

caagcaatgg ctacaacagc agttctgact accacctttc aggcacctac ggactcgaaa     1200

ggcagcttag aaaccatacc gtttacagaa atctccaacc taactttgaa cacagggaat     1260

gtgtataacc ctactgcact ttctatgtca aatgtggagt cttccactat gaataaaact     1320

gcttcctggg aaggtaggga ggccagtcca ggcagttcct cccagggcag tgttccagaa     1380

aatcagtacg gccttccatt tgaaaaatgg cttcttatcg ggtccctgct ctttggtgtc     1440

ctgttcctgg tgataggcct cgtcctcctg ggtagaatcc tctcggaatc actccgcagg     1500

aaacgttact caagactgga ttatttgatc aatgggatct atgtggacat ctaaggatgg     1560

aactcggtgt ctcttaattc atttagtaac cagaagccca aatgcaatga gtttctgctg     1620

acttgctagt cttagcagga ggttgtattt tgaagacagg aaaatgcccc cttctgcttt     1680

cctttttttt ttttggagac agagtcttgc tttgttgccc aggctggagt gcagtagcac     1740

gatctcggct ctcaccgcaa cctccgtctc ctgggttcaa gcgattctcc tgcctcagcc     1800

tcctaagtat ctgggattac aggcatgtgc caccacacct gggtgatttt tgtattttta     1860

gtagagacgg ggtttcacca tgttggtcag gctggtctca aactcctgac ctagtgatcc     1920

accctcctcg gcctcccaaa gtgctgggat tacaggcatg agccaccaca gctggccccc     1980

ttctgtttta tgtttggttt ttgagaagga atgaagtggg aaccaaatta ggtaattttg     2040

ggtaatctgt ctctaaaata ttagctaaaa acaaagctct atgtaaagta ataaagtata     2100

attgccatat aaatttcaaa attcaactgg cttttatgca aagaaacagg ttaggacatc     2160

taggttccaa ttcattcaca ttcttggttc cagataaaat caactgttta tatcaatttc     2220

taatggattt gcttttcttt ttatatggat tcctttaaaa cttattccag atgtagttcc     2280

ttccaattaa atatttg                                                    2297


<210> 46
<211> 431
<212> PRT
<213> Homo sapiens

<400> 46
Met Phe Phe Gly Gly Glu Gly Ser Leu Thr Tyr Thr Leu Val Ile Ile 
1               5                   10                  15      


Cys Phe Leu Thr Leu Arg Leu Ser Ala Ser Gln Asn Cys Leu Lys Lys 
            20                  25                  30          


Ser Leu Glu Asp Val Val Ile Asp Ile Gln Ser Ser Leu Ser Lys Gly 
        35                  40                  45              


Ile Arg Gly Asn Glu Pro Val Tyr Thr Ser Thr Gln Glu Asp Cys Ile 
    50                  55                  60                  


Asn Ser Cys Cys Ser Thr Lys Asn Ile Ser Gly Asp Lys Ala Cys Asn 
65                  70                  75                  80  


Leu Met Ile Phe Asp Thr Arg Lys Thr Ala Arg Gln Pro Asn Cys Tyr 
                85                  90                  95      


Leu Phe Phe Cys Pro Asn Glu Glu Ala Cys Pro Leu Lys Pro Ala Lys 
            100                 105                 110         


Gly Leu Met Ser Tyr Arg Ile Ile Thr Asp Phe Pro Ser Leu Thr Arg 
        115                 120                 125             


Asn Leu Pro Ser Gln Glu Leu Pro Gln Glu Asp Ser Leu Leu His Gly 
    130                 135                 140                 


Gln Phe Ser Gln Ala Val Thr Pro Leu Ala His His His Thr Asp Tyr 
145                 150                 155                 160 


Ser Lys Pro Thr Asp Ile Ser Trp Arg Asp Thr Leu Ser Gln Lys Phe 
                165                 170                 175     


Gly Ser Ser Asp His Leu Glu Lys Leu Phe Lys Met Asp Glu Ala Ser 
            180                 185                 190         


Ala Gln Leu Leu Ala Tyr Lys Glu Lys Gly His Ser Gln Ser Ser Gln 
        195                 200                 205             


Phe Ser Ser Asp Gln Glu Ile Ala His Leu Leu Pro Glu Asn Val Ser 
    210                 215                 220                 


Ala Leu Pro Ala Thr Val Ala Val Ala Ser Pro His Thr Thr Ser Ala 
225                 230                 235                 240 


Thr Pro Lys Pro Ala Thr Leu Leu Pro Thr Asn Ala Ser Val Thr Pro 
                245                 250                 255     


Ser Gly Thr Ser Gln Pro Gln Leu Ala Thr Thr Ala Pro Pro Val Thr 
            260                 265                 270         


Thr Val Thr Ser Gln Pro Pro Thr Thr Leu Ile Ser Thr Val Phe Thr 
        275                 280                 285             


Arg Ala Ala Ala Thr Leu Gln Ala Met Ala Thr Thr Ala Val Leu Thr 
    290                 295                 300                 


Thr Thr Phe Gln Ala Pro Thr Asp Ser Lys Gly Ser Leu Glu Thr Ile 
305                 310                 315                 320 


Pro Phe Thr Glu Ile Ser Asn Leu Thr Leu Asn Thr Gly Asn Val Tyr 
                325                 330                 335     


Asn Pro Thr Ala Leu Ser Met Ser Asn Val Glu Ser Ser Thr Met Asn 
            340                 345                 350         


Lys Thr Ala Ser Trp Glu Gly Arg Glu Ala Ser Pro Gly Ser Ser Ser 
        355                 360                 365             


Gln Gly Ser Val Pro Glu Asn Gln Tyr Gly Leu Pro Phe Glu Lys Trp 
    370                 375                 380                 


Leu Leu Ile Gly Ser Leu Leu Phe Gly Val Leu Phe Leu Val Ile Gly 
385                 390                 395                 400 


Leu Val Leu Leu Gly Arg Ile Leu Ser Glu Ser Leu Arg Arg Lys Arg 
                405                 410                 415     


Tyr Ser Arg Leu Asp Tyr Leu Ile Asn Gly Ile Tyr Val Asp Ile 
            420                 425                 430     


<210> 47
<211> 1336
<212> DNA
<213> Homo sapiens

<400> 47
gcgaggtggg gtaggcgggc aaggcgggcg ccgaggtttg caaaggctcg cagcggccag       60

aaacccggct ccgagcggcg gcggcccggc ttccgctgcc cgtgagctaa ggacggtccg      120

ctccctctag ccagctccga atcctgatcc aggcgggggc caggggcccc tcgcctcccc      180

tctgaggacc gaagatgagc ttcctcttca gcagccgctc ttctaaaaca ttcaaaccaa      240

agaagaatat ccctgaagga tctcatcagt atgaactctt aaaacatgca gaagcaactc      300

taggaagtgg gaatctgaga caagctgtta tgttgcctga gggagaggat ctcaatgaat      360

ggattgctgt gaacactgtg gatttcttta accagatcaa catgttatat ggaactatta      420

cagaattctg cactgaagca agctgtccag tcatgtctgc aggtccgaga tatgaatatc      480

actgggcaga tggtactaat attaaaaagc caatcaaatg ttctgcacca aaatacattg      540

actatttgat gacttgggtt caagatcagc ttgatgatga aactcttttt ccttctaaga      600

ttggtgtccc atttcccaaa aactttatgt ctgtggcaaa gactattcta aagcgtctgt      660

tcagggttta tgcccatatt tatcaccagc actttgattc tgtgatgcag ctgcaagagg      720

aggcccacct caacacctcc tttaagcact ttattttctt tgttcaggag tttaatctga      780

ttgataggcg tgagctggca cctcttcaag aattaataga gaaacttgga tcaaaagaca      840

gataaatgtt tcttctagaa cacagttacc cccttgcttc atctattgct agaactatct      900

cattgctatc tgttatagac tagtgataca aactttaaga aaacaggata aaaagatacc      960

cattgcctgt gtctactgat aaaattatcc caaaggtagg ttggtgtgat agtttccgag     1020

taagacctta aggacacagc caaatcttaa gtactgtgtg accactcttg ttgttatcac     1080

atagtcatac ttggttgtaa tatgtgatgg ttaacctgta gcttataaat ttacttatta     1140

ttcttttact catttactca gtcatttctt tacaagaaaa tgattgaatc tgttttaggt     1200

gacagcacaa tggacattaa gaatttccat caataattta tgaataagtt tccagaacaa     1260

atttcctaat aacacaatca gattggtttt attcttttat tttacgaata aaaaatgtat     1320

ttttcagtaa aaaaaa                                                     1336


<210> 48
<211> 216
<212> PRT
<213> Homo sapiens

<400> 48
Met Ser Phe Leu Phe Ser Ser Arg Ser Ser Lys Thr Phe Lys Pro Lys 
1               5                   10                  15      


Lys Asn Ile Pro Glu Gly Ser His Gln Tyr Glu Leu Leu Lys His Ala 
            20                  25                  30          


Glu Ala Thr Leu Gly Ser Gly Asn Leu Arg Gln Ala Val Met Leu Pro 
        35                  40                  45              


Glu Gly Glu Asp Leu Asn Glu Trp Ile Ala Val Asn Thr Val Asp Phe 
    50                  55                  60                  


Phe Asn Gln Ile Asn Met Leu Tyr Gly Thr Ile Thr Glu Phe Cys Thr 
65                  70                  75                  80  


Glu Ala Ser Cys Pro Val Met Ser Ala Gly Pro Arg Tyr Glu Tyr His 
                85                  90                  95      


Trp Ala Asp Gly Thr Asn Ile Lys Lys Pro Ile Lys Cys Ser Ala Pro 
            100                 105                 110         


Lys Tyr Ile Asp Tyr Leu Met Thr Trp Val Gln Asp Gln Leu Asp Asp 
        115                 120                 125             


Glu Thr Leu Phe Pro Ser Lys Ile Gly Val Pro Phe Pro Lys Asn Phe 
    130                 135                 140                 


Met Ser Val Ala Lys Thr Ile Leu Lys Arg Leu Phe Arg Val Tyr Ala 
145                 150                 155                 160 


His Ile Tyr His Gln His Phe Asp Ser Val Met Gln Leu Gln Glu Glu 
                165                 170                 175     


Ala His Leu Asn Thr Ser Phe Lys His Phe Ile Phe Phe Val Gln Glu 
            180                 185                 190         


Phe Asn Leu Ile Asp Arg Arg Glu Leu Ala Pro Leu Gln Glu Leu Ile 
        195                 200                 205             


Glu Lys Leu Gly Ser Lys Asp Arg 
    210                 215     


<210> 49
<211> 5381
<212> DNA
<213> Homo sapiens

<400> 49
attgagaggc caccgggaaa ccattgagaa gccccggagg accggcctga gcggaggcgg       60

agactagagc ggccgccggc acgacccgcc ttcaggcgta cgacgaccgc ggcccggggg      120

ctctgagtgg ccaaagcggc ggcactttct gcgtggcccc ggaaggacat agagcggaag      180

gcgggagaaa gaagtagccg gcaggcggag gcagcccgag ggggcggttg catgtgtgcc      240

agacgttcgt agcccactga gcttcctcac gccggctgtc gcagcgccta gccccacccg      300

gcggcctctc ctgcgcttcc ggggccgtgg cgagctagtg cgcctgcgtg ccggcccatc      360

cgcgcgcctt gcagctgtcc ttgcgtcggc cagcggccag acagttcctg cagcgcttac      420

cgcctggcct ctcggttccg cggcgcaccg gagggcagca tgtcgcggcg gcggcacagc      480

gacgagaacg acggtgggca gcctcacaaa aggagaaaga cctctgatgc aaatgaaact      540

gaagatcatt tggaatcttt aatatgtaaa gtaggagaaa agagtgcctg ctctttggag      600

agcaacctag aaggcttggc tggtgttttg gaagctgatc ttcctaacta caagagcaag      660

atcttaaggc ttctttgtac agttgcacgc ctattacctg agaagctgac aatttataca      720

acattagttg gactactgaa tgccaggaat tacaattttg gtggagaatt tgtagaagcc      780

atgattcgtc aacttaaaga atcattgaaa gcaaacaatt ataatgaagc cgtgtatttg      840

gtccgttttt tatctgatct tgtgaattgt catgtgattg ccgccccatc aatggttgct      900

atgtttgaaa attttgtaag cgtaactcag gaagaagatg tacctcaggt gcgacgagat      960

tggtatgtgt atgcatttct gtcatctttg ccctgggttg gaaaggagtt gtacgaaaag     1020

aaagatgcag agatggaccg catctttgcc aacactgaaa gctatcttaa aagacgccaa     1080

aagactcatg tacccatgtt acaggtatgg actgctgata aaccacatcc acaagaagag     1140

tatttagatt gcctgtgggc ccagattcag aaattgaaaa aggatcgctg gcaggaacgg     1200

cacatcctaa gaccttatct tgcctttgac agcatcctgt gtgaagcact gcagcacaat     1260

ctgcctcctt ttacaccacc tcctcacact gaagattcag tgtacccaat gccaagggtc     1320

atcttcagaa tgtttgatta cacagatgat cccgagggtc ctgtcatgcc agggagtcat     1380

tcagtggaaa gatttgtaat agaagagaat cttcactgca tcattaagtc ccactggaag     1440

gaaaggaaga cttgtgctgc acagttagtg agctatccag ggaagaacaa gatccccttg     1500

aactaccaca tagttgaggt gatctttgca gagctgtttc aacttccagc accccctcac     1560

attgatgtga tgtacacaac actcctcatt gaactgtgca aacttcaacc tggctctcta     1620

ccccaagttc ttgcacaggc aactgaaatg ctatacatgc gtttggacac aatgaacact     1680

acctgtgtag acaggtttat taattggttt tctcatcatc taagtaactt ccagttccgt     1740

tggagctggg aagattggtc agattgtctt agtcaagatc ctgaaagtcc caaaccgaag     1800

tttgtaagag aagttctaga aaaatgtatg aggttgtctt accatcagcg tatattagat     1860

attgttcctc ctaccttctc agctctgtgt cctgcaaacc caacctgcat ttacaagtat     1920

ggagatgaaa gtagcaattc tcttcctgga cattctgttg ccctctgttt agctgttgcc     1980

tttaaaagta aggcaaccaa tgatgaaatc ttcagcattc tgaaagatgt accaaatcct     2040

aaccaggatg atgacgacga tgaaggattc agttttaacc cattgaaaat agaagtcttt     2100

gtacagactc tgctacactt ggcagccaaa tcattcagcc actccttcag tgctcttgca     2160

aagtttcatg aagtcttcaa aaccctagct gaaagtgatg aaggaaagtt acatgtgcta     2220

agagttatgt ttgaggtctg gaggaaccat ccacagatga ttgctgtact agtggataag     2280

atgattcgta cacaaatagt tgattgtgct gccgtagcaa attggatctt ctcttcagaa     2340

ctatctcgtg actttaccag attgtttgtt tgggaaattt tgcactctac aattcgtaag     2400

atgaacaaac atgtcctgaa gatccagaaa gagctggaag aagctaaaga gaaacttgct     2460

aggcaacaca aacggcgaag tgatgatgac gacagaagca gtgacaggaa agacggggtt     2520

cttgaggaac aaatagaacg acttcaggaa aaagtggaat ctgctcagag tgaacaaaag     2580

aatcttttcc tcgttatatt tcagcggttt atcatgatct tgaccgagca cctagtacga     2640

tgcgaaactg atgggaccag tgtattaaca ccatggtata agaactgtat agagaggctg     2700

cagcagatct tcctacagca tcaccaaata atccagcagt acatggtgac cctggagaac     2760

cttctcttca ctgctgaatt agaccctcat atcttggccg tgttccagca gttctgtgcc     2820

ctgcaggcct aagggtcatt ttttcctcat gtcaaggttt tttttgatat cttaaaataa     2880

tttgtcttat tttttgatgg tttgaatgct tgctttcttg tagtatcctt tcacttctta     2940

aaggaaacaa aggggaagag gacagtgaat gaacatggca ttacttttaa ttgccctgaa     3000

aagcaaatac ttcctaacgg cagtaatgtg actatgacca tgatatatta tatatgtgac     3060

agatacaaat tctctgtgat cagtttgtta ttttttttct ccttaaggca caaaataatt     3120

ggtttgaggt atgtgaaaca ctagaggtca accttacata gtatatagaa ctgatgggtt     3180

tacccagcta cccagtagca taacttttca cagctcgggg atgaattaac atggctgaaa     3240

taaaactaaa agtatggttt ttaaactttg gcatttcatg atttatcatc tcactctact     3300

ctaaaactgg tggtttctta ctgaaggtgt tctccatttg aaattttatc ttcaaagtat     3360

ttttaagtag tatctttaag acatgacttg ttagtaataa aagtgttact agttggaaga     3420

gtagctctca aatttgtctt aatgtaaatc acctgggaat ctttcaagtt attttgaaat     3480

ttaaaccacc gtctgggggt ggaacgcaga catcctcagt aatccttaaa gtttccccag     3540

gtgattccag gtttggtcac cattatctta gagcatctac tcacttcctc tagccttggg     3600

gttatttgtc caaggtcttg tagtgagtta cagaatacta aagtggatgt agaagtggtc     3660

agattgactg aaactatacc ctgaattaga tgtgagttta gattttgttt atatggaacc     3720

tgatccaaaa aactacgaag tcctgagctt gtttcctgta tagtactgat gctgaaataa     3780

gatgacagca gtttgtaaaa taatacacaa atatgaggaa ttgtctgaca ttccaaattt     3840

cgaggatttt tagacttttt tcattaaacc ttagaaaaaa attaccagta atcctacaac     3900

tactggtagt gttgttgtgc atttgcacaa aataggtata attttttctt attacatccc     3960

aagtttatga tgcattaagc gttttgcata ttttgatata tttttgcttt ggtttaccat     4020

acattttagt ggctacagaa tgtagtctgc ttaataaatg ggaattccta gaatgtttaa     4080

ataccatact atttaagaca aaatacaaaa tatccagaaa aatccaggtt gcgtggctgg     4140

ttagtaaagg actaaaaccc aggttcttgg ctaaatgttt tcgtttatac tgtttatctt     4200

tcccattgct taagcacagc acaaactatg taattatata taattacagt tgacccttga     4260

acaacatggg tttgaactgt gtgagtctcc ttacacacag gttttcttcc acccctgaga     4320

tggcaagacc agccccttgt cttcctcagc ctgctcaacg tgaagatgat gaggatgaag     4380

acctttatga tgatccactt ctacttatta aatagtaaat atattttttt cttatgattt     4440

tattttcttt tctctagctt cataagaata tagcatatgg gctgggcgca gtggctcacg     4500

cctgtaatcc cagcactttg ggaggctgag gcgggcggat cacaaggtca ggagattgag     4560

accatcctgg ctaacacagt gaaaccctgt ctctactaaa aacacaaaaa cttagccagg     4620

cgtggtggta catggctgta gtcccagcta cttgggaggc tgagacagga gaatcgcttg     4680

aacctgggag gtggaggttt cagtgagcca agattgtgcc actgcactcc agcctgggtg     4740

atggagcgag gctctgtctc aaaaaagaaa aaaaatatat agcatataac atacaaaatg     4800

agtttatcaa ctgtttgtta ttggtaagtc agcagtgggc tattggtggt taagttttgg     4860

gggagtcaaa agttacatgc aaatttttta ctgtgcgggg tgtcagcatc cctaacccca     4920

tgttgttcaa gggtcaactg tagtttaaaa tgactcctgt ctcaaaaaac caaaggataa     4980

cctttaaggg attggtaact ttgactcaaa actgctttgt aatcttttca caatgtactg     5040

aaaagtgtgg ctagttatgt ttgatccaca ttctagagaa atttgtaggt tttaatttct     5100

tttctcttgg tcctctcttc atgtataatg gttgctttta acagctgttc gctgatgtgg     5160

tcctgctctg tcccagtcta gcagctttag tgtatggaaa aattgaacta ggaattgagt     5220

tttgaagaaa taaaggtgta agagcaaaca ttcaacagtt gctgtcccca gtaatgaagt     5280

tcatacagac aaaagatggc atgtcactgt acatcatacc ttgcaataaa tattctgtta     5340

aattgtgctg gtgcaattta acatgctttt gtcaaagtaa a                         5381


<210> 50
<211> 790
<212> PRT
<213> Homo sapiens

<400> 50
Met Ser Arg Arg Arg His Ser Asp Glu Asn Asp Gly Gly Gln Pro His 
1               5                   10                  15      


Lys Arg Arg Lys Thr Ser Asp Ala Asn Glu Thr Glu Asp His Leu Glu 
            20                  25                  30          


Ser Leu Ile Cys Lys Val Gly Glu Lys Ser Ala Cys Ser Leu Glu Ser 
        35                  40                  45              


Asn Leu Glu Gly Leu Ala Gly Val Leu Glu Ala Asp Leu Pro Asn Tyr 
    50                  55                  60                  


Lys Ser Lys Ile Leu Arg Leu Leu Cys Thr Val Ala Arg Leu Leu Pro 
65                  70                  75                  80  


Glu Lys Leu Thr Ile Tyr Thr Thr Leu Val Gly Leu Leu Asn Ala Arg 
                85                  90                  95      


Asn Tyr Asn Phe Gly Gly Glu Phe Val Glu Ala Met Ile Arg Gln Leu 
            100                 105                 110         


Lys Glu Ser Leu Lys Ala Asn Asn Tyr Asn Glu Ala Val Tyr Leu Val 
        115                 120                 125             


Arg Phe Leu Ser Asp Leu Val Asn Cys His Val Ile Ala Ala Pro Ser 
    130                 135                 140                 


Met Val Ala Met Phe Glu Asn Phe Val Ser Val Thr Gln Glu Glu Asp 
145                 150                 155                 160 


Val Pro Gln Val Arg Arg Asp Trp Tyr Val Tyr Ala Phe Leu Ser Ser 
                165                 170                 175     


Leu Pro Trp Val Gly Lys Glu Leu Tyr Glu Lys Lys Asp Ala Glu Met 
            180                 185                 190         


Asp Arg Ile Phe Ala Asn Thr Glu Ser Tyr Leu Lys Arg Arg Gln Lys 
        195                 200                 205             


Thr His Val Pro Met Leu Gln Val Trp Thr Ala Asp Lys Pro His Pro 
    210                 215                 220                 


Gln Glu Glu Tyr Leu Asp Cys Leu Trp Ala Gln Ile Gln Lys Leu Lys 
225                 230                 235                 240 


Lys Asp Arg Trp Gln Glu Arg His Ile Leu Arg Pro Tyr Leu Ala Phe 
                245                 250                 255     


Asp Ser Ile Leu Cys Glu Ala Leu Gln His Asn Leu Pro Pro Phe Thr 
            260                 265                 270         


Pro Pro Pro His Thr Glu Asp Ser Val Tyr Pro Met Pro Arg Val Ile 
        275                 280                 285             


Phe Arg Met Phe Asp Tyr Thr Asp Asp Pro Glu Gly Pro Val Met Pro 
    290                 295                 300                 


Gly Ser His Ser Val Glu Arg Phe Val Ile Glu Glu Asn Leu His Cys 
305                 310                 315                 320 


Ile Ile Lys Ser His Trp Lys Glu Arg Lys Thr Cys Ala Ala Gln Leu 
                325                 330                 335     


Val Ser Tyr Pro Gly Lys Asn Lys Ile Pro Leu Asn Tyr His Ile Val 
            340                 345                 350         


Glu Val Ile Phe Ala Glu Leu Phe Gln Leu Pro Ala Pro Pro His Ile 
        355                 360                 365             


Asp Val Met Tyr Thr Thr Leu Leu Ile Glu Leu Cys Lys Leu Gln Pro 
    370                 375                 380                 


Gly Ser Leu Pro Gln Val Leu Ala Gln Ala Thr Glu Met Leu Tyr Met 
385                 390                 395                 400 


Arg Leu Asp Thr Met Asn Thr Thr Cys Val Asp Arg Phe Ile Asn Trp 
                405                 410                 415     


Phe Ser His His Leu Ser Asn Phe Gln Phe Arg Trp Ser Trp Glu Asp 
            420                 425                 430         


Trp Ser Asp Cys Leu Ser Gln Asp Pro Glu Ser Pro Lys Pro Lys Phe 
        435                 440                 445             


Val Arg Glu Val Leu Glu Lys Cys Met Arg Leu Ser Tyr His Gln Arg 
    450                 455                 460                 


Ile Leu Asp Ile Val Pro Pro Thr Phe Ser Ala Leu Cys Pro Ala Asn 
465                 470                 475                 480 


Pro Thr Cys Ile Tyr Lys Tyr Gly Asp Glu Ser Ser Asn Ser Leu Pro 
                485                 490                 495     


Gly His Ser Val Ala Leu Cys Leu Ala Val Ala Phe Lys Ser Lys Ala 
            500                 505                 510         


Thr Asn Asp Glu Ile Phe Ser Ile Leu Lys Asp Val Pro Asn Pro Asn 
        515                 520                 525             


Gln Asp Asp Asp Asp Asp Glu Gly Phe Ser Phe Asn Pro Leu Lys Ile 
    530                 535                 540                 


Glu Val Phe Val Gln Thr Leu Leu His Leu Ala Ala Lys Ser Phe Ser 
545                 550                 555                 560 


His Ser Phe Ser Ala Leu Ala Lys Phe His Glu Val Phe Lys Thr Leu 
                565                 570                 575     


Ala Glu Ser Asp Glu Gly Lys Leu His Val Leu Arg Val Met Phe Glu 
            580                 585                 590         


Val Trp Arg Asn His Pro Gln Met Ile Ala Val Leu Val Asp Lys Met 
        595                 600                 605             


Ile Arg Thr Gln Ile Val Asp Cys Ala Ala Val Ala Asn Trp Ile Phe 
    610                 615                 620                 


Ser Ser Glu Leu Ser Arg Asp Phe Thr Arg Leu Phe Val Trp Glu Ile 
625                 630                 635                 640 


Leu His Ser Thr Ile Arg Lys Met Asn Lys His Val Leu Lys Ile Gln 
                645                 650                 655     


Lys Glu Leu Glu Glu Ala Lys Glu Lys Leu Ala Arg Gln His Lys Arg 
            660                 665                 670         


Arg Ser Asp Asp Asp Asp Arg Ser Ser Asp Arg Lys Asp Gly Val Leu 
        675                 680                 685             


Glu Glu Gln Ile Glu Arg Leu Gln Glu Lys Val Glu Ser Ala Gln Ser 
    690                 695                 700                 


Glu Gln Lys Asn Leu Phe Leu Val Ile Phe Gln Arg Phe Ile Met Ile 
705                 710                 715                 720 


Leu Thr Glu His Leu Val Arg Cys Glu Thr Asp Gly Thr Ser Val Leu 
                725                 730                 735     


Thr Pro Trp Tyr Lys Asn Cys Ile Glu Arg Leu Gln Gln Ile Phe Leu 
            740                 745                 750         


Gln His His Gln Ile Ile Gln Gln Tyr Met Val Thr Leu Glu Asn Leu 
        755                 760                 765             


Leu Phe Thr Ala Glu Leu Asp Pro His Ile Leu Ala Val Phe Gln Gln 
    770                 775                 780                 


Phe Cys Ala Leu Gln Ala 
785                 790 


<210> 51
<211> 818
<212> DNA
<213> Homo sapiens

<400> 51
agtcctgtgt ccgggccccg aggcacagcc agggcaccag gtggagcacc agctacgcgt       60

ggcgcagcgc agcgtcccta gcaccgagcc tcccgcagcc gccgagatgc tgcgaacaga      120

gagctgccgc cccaggtcgc ccgccggaca ggtggccgcg gcgtccccgc tcctgctgct      180

gctgctgctg ctcgcctggt gcgcgggcgc ctgccgaggt gctccaatat tacctcaagg      240

attacagcct gaacaacagc tacagttgtg gaatgagata gatgatactt gttcgtcttt      300

tctgtccatt gattctcagc ctcaggcatc caacgcactg gaggagcttt gctttatgat      360

tatgggaatg ctaccaaagc ctcaggaaca agatgaaaaa gataatacta aaaggttctt      420

atttcattat tcgaagacac agaagttggg caagtcaaat gttgtgtcgt cagttgtgca      480

tccgttgctg cagctcgttc ctcacctgca tgagagaaga atgaagagat tcagagtgga      540

cgaagaattc caaagtccct ttgcaagtca aagtcgagga tattttttat tcaggccacg      600

gaatggaaga aggtcagcag ggttcattta aaatggatgc cagctaattt tccacagagc      660

aatgctatgg aatacaaaat gtactgacat tttgttttct tctgaaaaaa atccttgcta      720

aatgtactct gttgaaaatc cctgtgttgt caatgttctc agttgtaaca atgttgtaaa      780

tgttcaattt gttgaaaatt aaaaaatcta aaaataaa                              818


<210> 52
<211> 174
<212> PRT
<213> Homo sapiens

<400> 52
Met Leu Arg Thr Glu Ser Cys Arg Pro Arg Ser Pro Ala Gly Gln Val 
1               5                   10                  15      


Ala Ala Ala Ser Pro Leu Leu Leu Leu Leu Leu Leu Leu Ala Trp Cys 
            20                  25                  30          


Ala Gly Ala Cys Arg Gly Ala Pro Ile Leu Pro Gln Gly Leu Gln Pro 
        35                  40                  45              


Glu Gln Gln Leu Gln Leu Trp Asn Glu Ile Asp Asp Thr Cys Ser Ser 
    50                  55                  60                  


Phe Leu Ser Ile Asp Ser Gln Pro Gln Ala Ser Asn Ala Leu Glu Glu 
65                  70                  75                  80  


Leu Cys Phe Met Ile Met Gly Met Leu Pro Lys Pro Gln Glu Gln Asp 
                85                  90                  95      


Glu Lys Asp Asn Thr Lys Arg Phe Leu Phe His Tyr Ser Lys Thr Gln 
            100                 105                 110         


Lys Leu Gly Lys Ser Asn Val Val Ser Ser Val Val His Pro Leu Leu 
        115                 120                 125             


Gln Leu Val Pro His Leu His Glu Arg Arg Met Lys Arg Phe Arg Val 
    130                 135                 140                 


Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg Gly Tyr Phe 
145                 150                 155                 160 


Leu Phe Arg Pro Arg Asn Gly Arg Arg Ser Ala Gly Phe Ile 
                165                 170                 


<210> 53
<211> 5849
<212> DNA
<213> Homo sapiens

<400> 53
gcgttccttg cggcccggcc gacctcgcgg gcttgggcct gggcgggcac cgacggagcg       60

gccctggctg cagcctcccg gcgccagcga agacaggctg agatgcggct gctcctgctc      120

gtgccgctgc tgctggctcc agcgcccggg tcctcggctc ccaaggtgag gcggcagagt      180

gacacctggg gaccctggag ccagtggagc ccctgcagcc ggacctgtgg agggggtgtc      240

agcttccggg agcgcccctg ctactcccag aggagagatg gaggctccag ctgcgtgggc      300

cccgcccgga gccaccgctc ttgtcgcacg gagagctgcc ccgacggcgc ccgggacttc      360

cgggccgagc agtgcgcgga gttcgacgga gcggagttcc aggggcggcg gtatcggtgg      420

ctgccctact acagcgcccc aaacaagtgt gaactgaact gcattcccaa gggggagaac      480

ttctactaca agcacaggga ggctgtggtt gatgggacgc cctgcgagcc tggcaagagg      540

gatgtctgtg tggatggcag ctgccgggtt gtcggctgtg atcacgagct ggactcgtcc      600

aagcaggagg acaagtgtct gcggtgtggg ggtgacggca cgacctgcta ccccgtcgca      660

ggcacctttg acgctaatga cctcagccga gctgtgaaga atgttcgtgg ggaatactac      720

ctcaatgggc actggaccat cgaggcggcc cgggccctgc cagcagccag caccatcctg      780

cattacgagc ggggtgctga gggggacctg gcccctgagc gactccatgc ccggggcccc      840

acctcggagc ccctggtcat cgagctcatc agccaggagc ccaaccccgg tgtgcactat      900

gagtaccacc tgcccctgcg ccgccccagc cccggcttca gctggagcca cggctcatgg      960

agtgactgca gcgcggagtg tggcggaggt caccagtccc gcctggtgtt ctgcaccatc     1020

gaccatgagg cctaccccga ccacatgtgc cagcgccagc cacggccagc tgaccggcgt     1080

tcctgcaatc ttcacccttg cccggagacc aagcgctgga aggcagggcc atgggcaccc     1140

tgctcagcct cctgtggagg aggctcccag tcccgctccg tgtactgcat ctcgtctgac     1200

ggggccggca tccaggaggc cgtggaggag gctgagtgtg ccgggctgcc tgggaagccc     1260

cctgccattc aggcctgtaa cctgcagcgc tgtgcagcct ggagcccgga gccctgggga     1320

gagtgttctg tcagttgtgg cgttggcgtc cggaagcgga gcgttacttg ccggggtgaa     1380

aggggttctt tgctccatac cgcagcgtgc tccttggaag accggccacc tctgactgag     1440

ccctgtgtgc atgaggactg ccccctcctc agtgaccagg cctggcatgt tggcacctgg     1500

ggtctatgct ccaagagctg cagctcgggc actcggaggc gacaggtcat ctgtgccatt     1560

gggccgccca gccactgcgg gagcctgcag cactccaagc ctgtggatgt ggagccttgt     1620

aacacgcagc cctgtcatct cccccaggag gtccccagca tgcaggatgt gcacacccct     1680

gccagcaacc cctggatgcc gttgggccct caggagtccc ctgcctcaga ctccagaggc     1740

cagtggtggg cagcccagga acacccctca gccaggggtg accacagggg agaacgaggt     1800

gaccccaggg gcgaccaagg cacccacctg tcagccctgg gccccgctcc ctctctgcag     1860

cagcccccat accagcaacc cctgcggtcg ggctcagggc cccacgactg cagacacagt     1920

cctcacgggt gctgccccga tggccacacg gcatctctcg ggcctcagtg gcaaggctgc     1980

cctggggccc cctgtcagca gagcaggtac gggtgctgcc ctgacagggt atctgtcgct     2040

gaggggcccc atcacgctgg ctgcacaaag tcgtatggtg gtgacagcac cgggggcatg     2100

cccaggtcaa gggcagtggc ttctacagtc cacaacaccc accagcccca ggcccagcag     2160

aatgagccca gtgagtgccg gggctcccag tttggctgtt gctatgacaa cgtggccact     2220

gcagccggtc ctcttgggga aggctgtgtg ggccagccca gccatgccta ccccgtgcgg     2280

tgcctgctgc ccagtgccca tggctcttgc gcagactggg ctgcccgctg gtacttcgtt     2340

gcctctgtgg gccaatgtaa ccgcttctgg tatggcggct gccatggcaa tgccaataac     2400

tttgcctcgg agcaagagtg catgagcagc tgccagggat ctctccatgg gccccgtcgt     2460

ccccagcctg gggcttctgg aaggagcacc cacacggatg gtggcggcag cagtcctgca     2520

ggcgagcagg aacccagcca gcacaggaca ggggccgcgg tgcagagaaa gccctggcct     2580

tctggtggtc tctggcggca agaccaacag cctgggccag gggaggcccc ccacacccag     2640

gcctttggag aatggccatg ggggcaggag cttgggtcca gggcccctgg actgggtgga     2700

gatgccggat caccagcgcc acccttccac agctcctcct acaggattag cttggcaggt     2760

gtggagccct cgttggtgca ggcagccctg gggcagttgg tgcggctctc ctgctcagac     2820

gacactgccc cggaatccca ggctgcctgg cagaaagatg gccagcccat ctcctctgac     2880

aggcacaggc tgcagttcga cggatccctg atcatccacc ccctgcaggc agaggacgcg     2940

ggcacctaca gctgtggcag cacccggcca ggccgcgact cccagaagat ccaacttcgc     3000

atcatagggg gtgacatggc cgtgctgtct gaggctgagc tgagccgctt ccctcagccc     3060

agggacccag ctcaggactt tggccaagcg ggggctgctg ggcccctggg ggccatcccc     3120

tcttcacacc cacagcctgc aaacaggctg cgtttggacc agaaccagcc ccgggtggtg     3180

gatgccagtc caggccagcg gatccggatg acctgccgtg ccgaaggctt cccgccccca     3240

gccatcgagt ggcagagaga tgggcagcct gtctcttctc ccagacacca gctgcagcct     3300

gatggctccc tggtcattag ccgagtggct gtagaagatg gcggcttcta cacctgtgtc     3360

gctttcaatg ggcaggaccg agaccagcga tgggtccagc tcagagttct gggggagctg     3420

acaatctcag gactgccccc tactgtgaca gtgccagagg gtgatacggc caggctattg     3480

tgtgtggtag caggagaaag tgtgaacatc aggtggtcca ggaacgggct acctgtgcag     3540

gctgatggcc accgtgtcca ccagtcccca gatggcacgc tgctcattta caacttgcgg     3600

gccagggatg agggctccta cacgtgcagt gcctaccagg ggagccaggc agtcagccgc     3660

agcaccgagg tgaaggtggt ctcaccagca cccaccgccc agcccaggga ccctggcagg     3720

gactgcgtcg accagccaga gctggccaac tgtgatttga tcctgcaggc ccagctttgt     3780

ggcaatgagt attactccag cttctgctgt gccagctgtt cacgtttcca gcctcacgct     3840

cagcccatct ggcagtaggg atgaaggcta gttccagccc cagtccaaaa tagttcatag     3900

ggctagggag aaaggaagat ggactcttgg cttcctctct ctggctggca aagggagtta     3960

tcttctggaa tacattagct ctttcaaaaa cccacccagt gtttagcctc aacggcagcc     4020

agttaccagc ttctctctgt agccttcagc agtgtttgca tctctgacat aaccacaggc     4080

tgctgttttc aagaagagca atctgtttgg ataagaaaaa cctttacttt acagcttccc     4140

tttataattt gttacacagg aatagttaaa tgcatttgtt tgtttgtttt ttgagacaga     4200

gtttcactct tgttgcccag gctggagggc aatggcgcga tctcagctca ctgcaacctc     4260

cgtctcctgg gttcttgatt ctcctgtgtc agccttctga gtagctagga ttacagatgc     4320

ctatcaccat gcctgggtaa tttttgtatt tttagttgag atggggtttc accatgttgg     4380

ccaggctggt ctcgaacttc tgacctcaga tgatctgccc gcctcagcct cccaaagtgc     4440

tgggattaca ggcatgagcc accacgccca gccatcaatg catttttttt attttttttt     4500

tgagacagag tttcgcactt cttgcccagg ctggagtaca atggtgcgat cttggctcac     4560

tgcaacctcc acctcctggg ttcaagcgct tctccagcct cagcctcctg agtagctggg     4620

attacaggta tgtgccacca tgcctggcta attttgtatt tttagtagag acggggtttc     4680

tccatgttgg tcagactggt cttgaactcc cgacctcagg taatccgccc gcctcggcct     4740

cccaaaatgc tgggattaga ggtgtgagcc actgtgccca gcccatcaat gtgttttaaa     4800

gctagctgtc agggttccac ttaatttaaa gctgggcagg gagatgtgta atgatttcaa     4860

agttaacacc tgtttgtttt ctaaagggca tgccaagtcc tgctgtatca gggaagtatt     4920

ctgtgctaaa atcagcgatg gttcattgct ctagtctctc tcacccttct aggcagtgca     4980

tcagtcagct ctaaatctgg tgcagagggt taacagcata acccttgttg gcaaaatgga     5040

atagatgtta agacctcaaa tagggatttg ggatgaaaca gctgcagtta gcactgttat     5100

ctgagcatga aagaactgga aacgctcctt acgtcgagat gttggacctt gaagccctcc     5160

tgaggccaac atgcaaatct ggctgtgacg gttcatctga cacctgtgta aagctgacca     5220

gcctgctctg tacagtgaca atgaggagcc cctctcttcc ttaagtagga atctgtgaag     5280

caaaatgttt gctgccaaag acaaatcaga ctgtcagtca ttaaaaacag cattagcagg     5340

atgaggatag caatggggaa gggttgtggg caatgcagta acagggaaat ggcttcagaa     5400

atggtttgag ttggaagaca acattcttca tctctcagga cttctaattc cttgatgcta     5460

aaagaagagg catggattct atgagcttcc aagtcccttt ccactttaac cttctacaaa     5520

tctttcagag gactgcctag tagcaaaggt tattcctgga cacaggaaag acgggcatta     5580

cagggaccaa agctctgaaa ggtgactttt attaccaaca cactggctgg aaaagggaca     5640

aaccacatca cgggtgagtg atacttctca gtcttctcta ctcattcaac aaaggaaatg     5700

tgggctgggg cagaggtctt ttttcattta atactggaaa aatattgaag agcatccatg     5760

ttcacttatg gctggttttg ctatagaaat tggaaaataa aggccacttt tttgaaatcc     5820

ccagtttaat taaaaaaaaa aaaaaaaaa                                       5849


<210> 54
<211> 1251
<212> PRT
<213> Homo sapiens

<400> 54
Met Arg Leu Leu Leu Leu Val Pro Leu Leu Leu Ala Pro Ala Pro Gly 
1               5                   10                  15      


Ser Ser Ala Pro Lys Val Arg Arg Gln Ser Asp Thr Trp Gly Pro Trp 
            20                  25                  30          


Ser Gln Trp Ser Pro Cys Ser Arg Thr Cys Gly Gly Gly Val Ser Phe 
        35                  40                  45              


Arg Glu Arg Pro Cys Tyr Ser Gln Arg Arg Asp Gly Gly Ser Ser Cys 
    50                  55                  60                  


Val Gly Pro Ala Arg Ser His Arg Ser Cys Arg Thr Glu Ser Cys Pro 
65                  70                  75                  80  


Asp Gly Ala Arg Asp Phe Arg Ala Glu Gln Cys Ala Glu Phe Asp Gly 
                85                  90                  95      


Ala Glu Phe Gln Gly Arg Arg Tyr Arg Trp Leu Pro Tyr Tyr Ser Ala 
            100                 105                 110         


Pro Asn Lys Cys Glu Leu Asn Cys Ile Pro Lys Gly Glu Asn Phe Tyr 
        115                 120                 125             


Tyr Lys His Arg Glu Ala Val Val Asp Gly Thr Pro Cys Glu Pro Gly 
    130                 135                 140                 


Lys Arg Asp Val Cys Val Asp Gly Ser Cys Arg Val Val Gly Cys Asp 
145                 150                 155                 160 


His Glu Leu Asp Ser Ser Lys Gln Glu Asp Lys Cys Leu Arg Cys Gly 
                165                 170                 175     


Gly Asp Gly Thr Thr Cys Tyr Pro Val Ala Gly Thr Phe Asp Ala Asn 
            180                 185                 190         


Asp Leu Ser Arg Ala Val Lys Asn Val Arg Gly Glu Tyr Tyr Leu Asn 
        195                 200                 205             


Gly His Trp Thr Ile Glu Ala Ala Arg Ala Leu Pro Ala Ala Ser Thr 
    210                 215                 220                 


Ile Leu His Tyr Glu Arg Gly Ala Glu Gly Asp Leu Ala Pro Glu Arg 
225                 230                 235                 240 


Leu His Ala Arg Gly Pro Thr Ser Glu Pro Leu Val Ile Glu Leu Ile 
                245                 250                 255     


Ser Gln Glu Pro Asn Pro Gly Val His Tyr Glu Tyr His Leu Pro Leu 
            260                 265                 270         


Arg Arg Pro Ser Pro Gly Phe Ser Trp Ser His Gly Ser Trp Ser Asp 
        275                 280                 285             


Cys Ser Ala Glu Cys Gly Gly Gly His Gln Ser Arg Leu Val Phe Cys 
    290                 295                 300                 


Thr Ile Asp His Glu Ala Tyr Pro Asp His Met Cys Gln Arg Gln Pro 
305                 310                 315                 320 


Arg Pro Ala Asp Arg Arg Ser Cys Asn Leu His Pro Cys Pro Glu Thr 
                325                 330                 335     


Lys Arg Trp Lys Ala Gly Pro Trp Ala Pro Cys Ser Ala Ser Cys Gly 
            340                 345                 350         


Gly Gly Ser Gln Ser Arg Ser Val Tyr Cys Ile Ser Ser Asp Gly Ala 
        355                 360                 365             


Gly Ile Gln Glu Ala Val Glu Glu Ala Glu Cys Ala Gly Leu Pro Gly 
    370                 375                 380                 


Lys Pro Pro Ala Ile Gln Ala Cys Asn Leu Gln Arg Cys Ala Ala Trp 
385                 390                 395                 400 


Ser Pro Glu Pro Trp Gly Glu Cys Ser Val Ser Cys Gly Val Gly Val 
                405                 410                 415     


Arg Lys Arg Ser Val Thr Cys Arg Gly Glu Arg Gly Ser Leu Leu His 
            420                 425                 430         


Thr Ala Ala Cys Ser Leu Glu Asp Arg Pro Pro Leu Thr Glu Pro Cys 
        435                 440                 445             


Val His Glu Asp Cys Pro Leu Leu Ser Asp Gln Ala Trp His Val Gly 
    450                 455                 460                 


Thr Trp Gly Leu Cys Ser Lys Ser Cys Ser Ser Gly Thr Arg Arg Arg 
465                 470                 475                 480 


Gln Val Ile Cys Ala Ile Gly Pro Pro Ser His Cys Gly Ser Leu Gln 
                485                 490                 495     


His Ser Lys Pro Val Asp Val Glu Pro Cys Asn Thr Gln Pro Cys His 
            500                 505                 510         


Leu Pro Gln Glu Val Pro Ser Met Gln Asp Val His Thr Pro Ala Ser 
        515                 520                 525             


Asn Pro Trp Met Pro Leu Gly Pro Gln Glu Ser Pro Ala Ser Asp Ser 
    530                 535                 540                 


Arg Gly Gln Trp Trp Ala Ala Gln Glu His Pro Ser Ala Arg Gly Asp 
545                 550                 555                 560 


His Arg Gly Glu Arg Gly Asp Pro Arg Gly Asp Gln Gly Thr His Leu 
                565                 570                 575     


Ser Ala Leu Gly Pro Ala Pro Ser Leu Gln Gln Pro Pro Tyr Gln Gln 
            580                 585                 590         


Pro Leu Arg Ser Gly Ser Gly Pro His Asp Cys Arg His Ser Pro His 
        595                 600                 605             


Gly Cys Cys Pro Asp Gly His Thr Ala Ser Leu Gly Pro Gln Trp Gln 
    610                 615                 620                 


Gly Cys Pro Gly Ala Pro Cys Gln Gln Ser Arg Tyr Gly Cys Cys Pro 
625                 630                 635                 640 


Asp Arg Val Ser Val Ala Glu Gly Pro His His Ala Gly Cys Thr Lys 
                645                 650                 655     


Ser Tyr Gly Gly Asp Ser Thr Gly Gly Met Pro Arg Ser Arg Ala Val 
            660                 665                 670         


Ala Ser Thr Val His Asn Thr His Gln Pro Gln Ala Gln Gln Asn Glu 
        675                 680                 685             


Pro Ser Glu Cys Arg Gly Ser Gln Phe Gly Cys Cys Tyr Asp Asn Val 
    690                 695                 700                 


Ala Thr Ala Ala Gly Pro Leu Gly Glu Gly Cys Val Gly Gln Pro Ser 
705                 710                 715                 720 


His Ala Tyr Pro Val Arg Cys Leu Leu Pro Ser Ala His Gly Ser Cys 
                725                 730                 735     


Ala Asp Trp Ala Ala Arg Trp Tyr Phe Val Ala Ser Val Gly Gln Cys 
            740                 745                 750         


Asn Arg Phe Trp Tyr Gly Gly Cys His Gly Asn Ala Asn Asn Phe Ala 
        755                 760                 765             


Ser Glu Gln Glu Cys Met Ser Ser Cys Gln Gly Ser Leu His Gly Pro 
    770                 775                 780                 


Arg Arg Pro Gln Pro Gly Ala Ser Gly Arg Ser Thr His Thr Asp Gly 
785                 790                 795                 800 


Gly Gly Ser Ser Pro Ala Gly Glu Gln Glu Pro Ser Gln His Arg Thr 
                805                 810                 815     


Gly Ala Ala Val Gln Arg Lys Pro Trp Pro Ser Gly Gly Leu Trp Arg 
            820                 825                 830         


Gln Asp Gln Gln Pro Gly Pro Gly Glu Ala Pro His Thr Gln Ala Phe 
        835                 840                 845             


Gly Glu Trp Pro Trp Gly Gln Glu Leu Gly Ser Arg Ala Pro Gly Leu 
    850                 855                 860                 


Gly Gly Asp Ala Gly Ser Pro Ala Pro Pro Phe His Ser Ser Ser Tyr 
865                 870                 875                 880 


Arg Ile Ser Leu Ala Gly Val Glu Pro Ser Leu Val Gln Ala Ala Leu 
                885                 890                 895     


Gly Gln Leu Val Arg Leu Ser Cys Ser Asp Asp Thr Ala Pro Glu Ser 
            900                 905                 910         


Gln Ala Ala Trp Gln Lys Asp Gly Gln Pro Ile Ser Ser Asp Arg His 
        915                 920                 925             


Arg Leu Gln Phe Asp Gly Ser Leu Ile Ile His Pro Leu Gln Ala Glu 
    930                 935                 940                 


Asp Ala Gly Thr Tyr Ser Cys Gly Ser Thr Arg Pro Gly Arg Asp Ser 
945                 950                 955                 960 


Gln Lys Ile Gln Leu Arg Ile Ile Gly Gly Asp Met Ala Val Leu Ser 
                965                 970                 975     


Glu Ala Glu Leu Ser Arg Phe Pro Gln Pro Arg Asp Pro Ala Gln Asp 
            980                 985                 990         


Phe Gly Gln Ala Gly Ala Ala Gly  Pro Leu Gly Ala Ile  Pro Ser Ser 
        995                 1000                 1005             


His Pro  Gln Pro Ala Asn Arg  Leu Arg Leu Asp Gln  Asn Gln Pro 
    1010                 1015                 1020             


Arg Val  Val Asp Ala Ser Pro  Gly Gln Arg Ile Arg  Met Thr Cys 
    1025                 1030                 1035             


Arg Ala  Glu Gly Phe Pro Pro  Pro Ala Ile Glu Trp  Gln Arg Asp 
    1040                 1045                 1050             


Gly Gln  Pro Val Ser Ser Pro  Arg His Gln Leu Gln  Pro Asp Gly 
    1055                 1060                 1065             


Ser Leu  Val Ile Ser Arg Val  Ala Val Glu Asp Gly  Gly Phe Tyr 
    1070                 1075                 1080             


Thr Cys  Val Ala Phe Asn Gly  Gln Asp Arg Asp Gln  Arg Trp Val 
    1085                 1090                 1095             


Gln Leu  Arg Val Leu Gly Glu  Leu Thr Ile Ser Gly  Leu Pro Pro 
    1100                 1105                 1110             


Thr Val  Thr Val Pro Glu Gly  Asp Thr Ala Arg Leu  Leu Cys Val 
    1115                 1120                 1125             


Val Ala  Gly Glu Ser Val Asn  Ile Arg Trp Ser Arg  Asn Gly Leu 
    1130                 1135                 1140             


Pro Val  Gln Ala Asp Gly His  Arg Val His Gln Ser  Pro Asp Gly 
    1145                 1150                 1155             


Thr Leu  Leu Ile Tyr Asn Leu  Arg Ala Arg Asp Glu  Gly Ser Tyr 
    1160                 1165                 1170             


Thr Cys  Ser Ala Tyr Gln Gly  Ser Gln Ala Val Ser  Arg Ser Thr 
    1175                 1180                 1185             


Glu Val  Lys Val Val Ser Pro  Ala Pro Thr Ala Gln  Pro Arg Asp 
    1190                 1195                 1200             


Pro Gly  Arg Asp Cys Val Asp  Gln Pro Glu Leu Ala  Asn Cys Asp 
    1205                 1210                 1215             


Leu Ile  Leu Gln Ala Gln Leu  Cys Gly Asn Glu Tyr  Tyr Ser Ser 
    1220                 1225                 1230             


Phe Cys  Cys Ala Ser Cys Ser  Arg Phe Gln Pro His  Ala Gln Pro 
    1235                 1240                 1245             


Ile Trp  Gln 
    1250     


<210> 55
<211> 3851
<212> DNA
<213> Homo sapiens

<400> 55
cgcaaagccg ccgggctgct gcgcccagag ccagccggag ccggagccgg agcccgaact       60

gcagctccag ccccagccgt gcggagccgc agcccaggcc ggggccggcg gcggctcatg      120

gacagcgggg cgggcggccg gcgctgcccg gaggcggccc tcctgattct ggggcctccc      180

aggatggagc acctgaggca cagcccaggc cctggggggc aacggctact gctgccctcc      240

atgctgctag cactgctgct cctgctggct ccatccccag gccacgccac tcgggtagtg      300

tacaaggtgc cggaggaaca gccacccaac accctcattg ggagcctcgc agccgactat      360

ggttttccag atgtggggca cctgtacaag ctagaggtgg gtgccccgta ccttcgcgtg      420

gatggcaaga caggtgacat tttcaccacc gagacctcca tcgaccgtga ggggctccgt      480

gaatgccaga accagctccc tggtgatccc tgcatcctgg agtttgaggt atctatcaca      540

gacctcgtgc agaatggcag cccccggctg ctagagggcc agatagaagt acaagacatc      600

aatgacaaca cacccaactt cgcctcacca gtcatcactc tggccatccc tgagaacacc      660

aacatcggct cactcttccc catcccgctg gcttcagacc gtgatgctgg tcccaacggt      720

gtggcatcct atgagctgca ggctgggcct gaggcccagg agctatttgg gctgcaggtg      780

gcagaggacc aggaggagaa gcaaccacag ctcattgtga tgggcaacct ggaccgtgag      840

cgctgggact cctatgacct caccatcaag gtgcaggatg gcggcagccc cccacgcgcc      900

agcagtgccc tgctgcgtgt caccgtgctt gacaccaatg acaacgcccc caagtttgag      960

cggccctcct atgaggccga actatctgag aatagcccca taggccactc ggtcatccag     1020

gtgaaggcca atgactcaga ccaaggtgcc aatgcagaaa tcgaatacac attccaccag     1080

gcgcccgaag ttgtgaggcg tcttcttcga ctggacagga acactggact tatcactgtt     1140

cagggcccgg tggaccgtga ggacctaagc accctgcgct tctcagtgct tgctaaggac     1200

cgaggcacca accccaagag tgcccgtgcc caggtggttg tgaccgtgaa ggacatgaat     1260

gacaatgccc ccaccattga gatccggggc atagggctag tgactcatca agatgggatg     1320

gctaacatct cagaggatgt ggcagaggag acagctgtgg ccctggtgca ggtgtctgac     1380

cgagatgagg gagagaatgc agctgtcacc tgtgtggtgg caggtgatgt gcccttccag     1440

ctgcgccagg ccagtgagac aggcagtgac agcaagaaga agtatttcct gcagactacc     1500

accccgctag actacgagaa ggtcaaagac tacaccattg agattgtggc tgtggactct     1560

ggcaaccccc cactctccag cactaactcc ctcaaggtgc aggtggtgga cgtcaatgac     1620

aacgcacctg tcttcactca gagtgtcact gaggtcgcct tcccggaaaa caacaagcct     1680

ggtgaagtga ttgctgagat cactgccagt gatgctgact ctggctctaa tgctgagctg     1740

gtttactctc tggagcctga gccggctgct aagggcctct tcaccatctc acccgagact     1800

ggagagatcc aggtgaagac atctctggat cgggaacagc gggagagcta tgagttgaag     1860

gtggtggcag ctgaccgggg cagtcctagc ctccagggca cagccactgt ccttgtcaat     1920

gtgctggact gcaatgacaa tgaccccaaa tttatgctga gtggctacaa cttctcagtg     1980

atggagaaca tgccagcact gagtccagtg ggcatggtga ctgtcattga tggagacaag     2040

ggggagaatg cccaggtgca gctctcagtg gagcaggaca acggtgactt tgttatccag     2100

aatggcacag gcaccatcct atccagcctg agctttgatc gagagcaaca aagcacctac     2160

accttccagc tgaaggcagt ggatggtggc gtcccacctc gctcagctta cgttggtgtc     2220

accatcaatg tgctggacga gaatgacaac gcaccctata tcactgcccc ttctaacacc     2280

tctcacaagc tgctgacccc ccagacacgt cttggtgaga cggtcagcca ggtggcagcc     2340

gaggactttg actctggtgt caatgctgag ctgatctaca gcattgcagg tggcaaccct     2400

tatggactct tccagattgg gtcacattca ggtgccatca ccctggagaa ggagattgag     2460

cggcgccacc atgggctaca ccgcctggtg gtgaaggtca gtgaccgcgg caagccccca     2520

cgctatggca cagccttggt ccatctttat gtcaatgaga ctctggccaa ccgcacgctg     2580

ctggagaccc tcctgggcca cagcctggac acgccgctgg atattgacat tgctggggat     2640

ccagaatatg agcgctccaa gcagcgtggc aacattctct ttggtgtggt ggctggtgtg     2700

gtggccgtgg ccttgctcat cgccctggcg gttcttgtgc gctactgcag acagcgggag     2760

gccaaaagtg gttaccaggc tggtaagaag gagaccaagg acctgtatgc ccccaagccc     2820

agtggcaagg cctccaaggg aaacaaaagc aaaggcaaga agagcaagtc cccaaagccc     2880

gtgaagccag tggaggacga ggatgaggcc gggctgcaga agtccctcaa gttcaacctg     2940

atgagcgatg cccctgggga cagtccccgc atccacctgc ccctcaacta cccaccaggc     3000

agccctgacc tgggccgcca ctatcgctct aactccccac tgccttccat ccagctgcag     3060

ccccagtcac cctcagcctc caagaagcac caggtggtac aggacctgcc acctgcaaac     3120

acattcgtgg gcaccgggga caccacgtcc acgggctctg agcagtactc cgactacagc     3180

taccgcacca acccccccaa ataccccagc aagcaggtag gccagccctt tcagctcagc     3240

acaccccagc ccctacccca cccctaccac ggagccatct ggaccgaggt gtgggagtga     3300

tggagcaggt ttactgtgcc tgcccgtgtt gggggccagc ctgagccagc agtgggaggt     3360

ggggccttag tgcctcaccg ggcacacgga ttaggctgag tgaagattaa gggagggtgt     3420

gctctgtggt ctcctccctg ccctctcccc actggggaga gacctgtgat ttgccaagtc     3480

cctggaccct ggaccagcta ctgggcctta tgggttgggg gtggtaggca ggtgagcgta     3540

agtggggagg gaaatgggta agaagtctac tccaaaccta ggtctctatg tcagaccaga     3600

cctaggtgct tctctaggag ggaaacaggg agacctgggg tcctgtggat aactgagtgg     3660

ggagtctgcc aggggagggc accttcccat tgtgccttct gtgtgtattg tgcattaacc     3720

tcttcctcac cactaggctt ctggggctgg gtcccacatg cccttgaccc tgacaataaa     3780

gttctctatt tttggaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3840

aaaaaaaaaa a                                                          3851


<210> 56
<211> 1060
<212> PRT
<213> Homo sapiens

<400> 56
Met Asp Ser Gly Ala Gly Gly Arg Arg Cys Pro Glu Ala Ala Leu Leu 
1               5                   10                  15      


Ile Leu Gly Pro Pro Arg Met Glu His Leu Arg His Ser Pro Gly Pro 
            20                  25                  30          


Gly Gly Gln Arg Leu Leu Leu Pro Ser Met Leu Leu Ala Leu Leu Leu 
        35                  40                  45              


Leu Leu Ala Pro Ser Pro Gly His Ala Thr Arg Val Val Tyr Lys Val 
    50                  55                  60                  


Pro Glu Glu Gln Pro Pro Asn Thr Leu Ile Gly Ser Leu Ala Ala Asp 
65                  70                  75                  80  


Tyr Gly Phe Pro Asp Val Gly His Leu Tyr Lys Leu Glu Val Gly Ala 
                85                  90                  95      


Pro Tyr Leu Arg Val Asp Gly Lys Thr Gly Asp Ile Phe Thr Thr Glu 
            100                 105                 110         


Thr Ser Ile Asp Arg Glu Gly Leu Arg Glu Cys Gln Asn Gln Leu Pro 
        115                 120                 125             


Gly Asp Pro Cys Ile Leu Glu Phe Glu Val Ser Ile Thr Asp Leu Val 
    130                 135                 140                 


Gln Asn Gly Ser Pro Arg Leu Leu Glu Gly Gln Ile Glu Val Gln Asp 
145                 150                 155                 160 


Ile Asn Asp Asn Thr Pro Asn Phe Ala Ser Pro Val Ile Thr Leu Ala 
                165                 170                 175     


Ile Pro Glu Asn Thr Asn Ile Gly Ser Leu Phe Pro Ile Pro Leu Ala 
            180                 185                 190         


Ser Asp Arg Asp Ala Gly Pro Asn Gly Val Ala Ser Tyr Glu Leu Gln 
        195                 200                 205             


Ala Gly Pro Glu Ala Gln Glu Leu Phe Gly Leu Gln Val Ala Glu Asp 
    210                 215                 220                 


Gln Glu Glu Lys Gln Pro Gln Leu Ile Val Met Gly Asn Leu Asp Arg 
225                 230                 235                 240 


Glu Arg Trp Asp Ser Tyr Asp Leu Thr Ile Lys Val Gln Asp Gly Gly 
                245                 250                 255     


Ser Pro Pro Arg Ala Ser Ser Ala Leu Leu Arg Val Thr Val Leu Asp 
            260                 265                 270         


Thr Asn Asp Asn Ala Pro Lys Phe Glu Arg Pro Ser Tyr Glu Ala Glu 
        275                 280                 285             


Leu Ser Glu Asn Ser Pro Ile Gly His Ser Val Ile Gln Val Lys Ala 
    290                 295                 300                 


Asn Asp Ser Asp Gln Gly Ala Asn Ala Glu Ile Glu Tyr Thr Phe His 
305                 310                 315                 320 


Gln Ala Pro Glu Val Val Arg Arg Leu Leu Arg Leu Asp Arg Asn Thr 
                325                 330                 335     


Gly Leu Ile Thr Val Gln Gly Pro Val Asp Arg Glu Asp Leu Ser Thr 
            340                 345                 350         


Leu Arg Phe Ser Val Leu Ala Lys Asp Arg Gly Thr Asn Pro Lys Ser 
        355                 360                 365             


Ala Arg Ala Gln Val Val Val Thr Val Lys Asp Met Asn Asp Asn Ala 
    370                 375                 380                 


Pro Thr Ile Glu Ile Arg Gly Ile Gly Leu Val Thr His Gln Asp Gly 
385                 390                 395                 400 


Met Ala Asn Ile Ser Glu Asp Val Ala Glu Glu Thr Ala Val Ala Leu 
                405                 410                 415     


Val Gln Val Ser Asp Arg Asp Glu Gly Glu Asn Ala Ala Val Thr Cys 
            420                 425                 430         


Val Val Ala Gly Asp Val Pro Phe Gln Leu Arg Gln Ala Ser Glu Thr 
        435                 440                 445             


Gly Ser Asp Ser Lys Lys Lys Tyr Phe Leu Gln Thr Thr Thr Pro Leu 
    450                 455                 460                 


Asp Tyr Glu Lys Val Lys Asp Tyr Thr Ile Glu Ile Val Ala Val Asp 
465                 470                 475                 480 


Ser Gly Asn Pro Pro Leu Ser Ser Thr Asn Ser Leu Lys Val Gln Val 
                485                 490                 495     


Val Asp Val Asn Asp Asn Ala Pro Val Phe Thr Gln Ser Val Thr Glu 
            500                 505                 510         


Val Ala Phe Pro Glu Asn Asn Lys Pro Gly Glu Val Ile Ala Glu Ile 
        515                 520                 525             


Thr Ala Ser Asp Ala Asp Ser Gly Ser Asn Ala Glu Leu Val Tyr Ser 
    530                 535                 540                 


Leu Glu Pro Glu Pro Ala Ala Lys Gly Leu Phe Thr Ile Ser Pro Glu 
545                 550                 555                 560 


Thr Gly Glu Ile Gln Val Lys Thr Ser Leu Asp Arg Glu Gln Arg Glu 
                565                 570                 575     


Ser Tyr Glu Leu Lys Val Val Ala Ala Asp Arg Gly Ser Pro Ser Leu 
            580                 585                 590         


Gln Gly Thr Ala Thr Val Leu Val Asn Val Leu Asp Cys Asn Asp Asn 
        595                 600                 605             


Asp Pro Lys Phe Met Leu Ser Gly Tyr Asn Phe Ser Val Met Glu Asn 
    610                 615                 620                 


Met Pro Ala Leu Ser Pro Val Gly Met Val Thr Val Ile Asp Gly Asp 
625                 630                 635                 640 


Lys Gly Glu Asn Ala Gln Val Gln Leu Ser Val Glu Gln Asp Asn Gly 
                645                 650                 655     


Asp Phe Val Ile Gln Asn Gly Thr Gly Thr Ile Leu Ser Ser Leu Ser 
            660                 665                 670         


Phe Asp Arg Glu Gln Gln Ser Thr Tyr Thr Phe Gln Leu Lys Ala Val 
        675                 680                 685             


Asp Gly Gly Val Pro Pro Arg Ser Ala Tyr Val Gly Val Thr Ile Asn 
    690                 695                 700                 


Val Leu Asp Glu Asn Asp Asn Ala Pro Tyr Ile Thr Ala Pro Ser Asn 
705                 710                 715                 720 


Thr Ser His Lys Leu Leu Thr Pro Gln Thr Arg Leu Gly Glu Thr Val 
                725                 730                 735     


Ser Gln Val Ala Ala Glu Asp Phe Asp Ser Gly Val Asn Ala Glu Leu 
            740                 745                 750         


Ile Tyr Ser Ile Ala Gly Gly Asn Pro Tyr Gly Leu Phe Gln Ile Gly 
        755                 760                 765             


Ser His Ser Gly Ala Ile Thr Leu Glu Lys Glu Ile Glu Arg Arg His 
    770                 775                 780                 


His Gly Leu His Arg Leu Val Val Lys Val Ser Asp Arg Gly Lys Pro 
785                 790                 795                 800 


Pro Arg Tyr Gly Thr Ala Leu Val His Leu Tyr Val Asn Glu Thr Leu 
                805                 810                 815     


Ala Asn Arg Thr Leu Leu Glu Thr Leu Leu Gly His Ser Leu Asp Thr 
            820                 825                 830         


Pro Leu Asp Ile Asp Ile Ala Gly Asp Pro Glu Tyr Glu Arg Ser Lys 
        835                 840                 845             


Gln Arg Gly Asn Ile Leu Phe Gly Val Val Ala Gly Val Val Ala Val 
    850                 855                 860                 


Ala Leu Leu Ile Ala Leu Ala Val Leu Val Arg Tyr Cys Arg Gln Arg 
865                 870                 875                 880 


Glu Ala Lys Ser Gly Tyr Gln Ala Gly Lys Lys Glu Thr Lys Asp Leu 
                885                 890                 895     


Tyr Ala Pro Lys Pro Ser Gly Lys Ala Ser Lys Gly Asn Lys Ser Lys 
            900                 905                 910         


Gly Lys Lys Ser Lys Ser Pro Lys Pro Val Lys Pro Val Glu Asp Glu 
        915                 920                 925             


Asp Glu Ala Gly Leu Gln Lys Ser Leu Lys Phe Asn Leu Met Ser Asp 
    930                 935                 940                 


Ala Pro Gly Asp Ser Pro Arg Ile His Leu Pro Leu Asn Tyr Pro Pro 
945                 950                 955                 960 


Gly Ser Pro Asp Leu Gly Arg His Tyr Arg Ser Asn Ser Pro Leu Pro 
                965                 970                 975     


Ser Ile Gln Leu Gln Pro Gln Ser Pro Ser Ala Ser Lys Lys His Gln 
            980                 985                 990         


Val Val Gln Asp Leu Pro Pro Ala  Asn Thr Phe Val Gly  Thr Gly Asp 
        995                 1000                 1005             


Thr Thr  Ser Thr Gly Ser Glu  Gln Tyr Ser Asp Tyr  Ser Tyr Arg 
    1010                 1015                 1020             


Thr Asn  Pro Pro Lys Tyr Pro  Ser Lys Gln Val Gly  Gln Pro Phe 
    1025                 1030                 1035             


Gln Leu  Ser Thr Pro Gln Pro  Leu Pro His Pro Tyr  His Gly Ala 
    1040                 1045                 1050             


Ile Trp  Thr Glu Val Trp Glu  
    1055                 1060 


<210> 57
<211> 3393
<212> DNA
<213> Homo sapiens

<400> 57
cctgcctgcc tccctgcgca cccgcagcct cccccgctgc ctccctaggg ctcccctccg       60

gccgccagcg cccatttttc attccctaga tagagatact ttgcgcgcac acacatacat      120

acgcgcgcaa aaaggaaaaa aaaaaaaaaa agcccaccct ccagcctcgc tgcaaagaga      180

aaaccggagc agccgcagct cgcagctcgc agctcgcagc ccgcagcccg cagaggacgc      240

ccagagcggc gagcgggcgg gcagacggac cgacggactc gcgccgcgtc cacctgtcgg      300

ccgggcccag ccgagcgcgc agcgggcacg ccgcgcgcgc ggagcagccg tgcccgccgc      360

ccgggccccg cgccagggcg cacacgctcc cgccccccta cccggcccgg gcgggagttt      420

gcacctctcc ctgcccgggt gctcgagctg ccgttgcaaa gccaactttg gaaaaagttt      480

tttgggggag acttgggcct tgaggtgccc agctccgcgc tttccgattt tgggggcctt      540

tccagaaaat gttgcaaaaa agctaagccg gcgggcagag gaaaacgcct gtagccggcg      600

agtgaagacg aaccatcgac tgccgtgttc cttttcctct tggaggttgg agtcccctgg      660

gcgcccccac acggctagac gcctcggctg gttcgcgacg cagccccccg gccgtggatg      720

ctcactcggg ctcgggatcc gcccaggtag cggcctcgga cccaggtcct gcgcccaggt      780

cctcccctgc cccccagcga cggagccggg gccgggggcg gcggcgcccg ggggccatgc      840

gggtgagccg cggctgcaga ggcctgagcg cctgatcgcc gcggacccga gccgagccca      900

cccccctccc cagcccccca ccctggccgc gggggcggcg cgctcgatct acgcgtccgg      960

ggccccgcgg ggccgggccc ggagtcggca tgaatcgctg ctgggcgctc ttcctgtctc     1020

tctgctgcta cctgcgtctg gtcagcgccg agggggaccc cattcccgag gagctttatg     1080

agatgctgag tgaccactcg atccgctcct ttgatgatct ccaacgcctg ctgcacggag     1140

accccggaga ggaagatggg gccgagttgg acctgaacat gacccgctcc cactctggag     1200

gcgagctgga gagcttggct cgtggaagaa ggagcctggg ttccctgacc attgctgagc     1260

cggccatgat cgccgagtgc aagacgcgca ccgaggtgtt cgagatctcc cggcgcctca     1320

tagaccgcac caacgccaac ttcctggtgt ggccgccctg tgtggaggtg cagcgctgct     1380

ccggctgctg caacaaccgc aacgtgcagt gccgccccac ccaggtgcag ctgcgacctg     1440

tccaggtgag aaagatcgag attgtgcgga agaagccaat ctttaagaag gccacggtga     1500

cgctggaaga ccacctggca tgcaagtgtg agacagtggc agctgcacgg cctgtgaccc     1560

gaagcccggg gggttcccag gagcagcgag ccaaaacgcc ccaaactcgg gtgaccattc     1620

ggacggtgcg agtccgccgg ccccccaagg gcaagcaccg gaaattcaag cacacgcatg     1680

acaagacggc actgaaggag acccttggag cctaggggca tcggcaggag agtgtgtggg     1740

cagggttatt taatatggta tttgctgtat tgcccccatg gggtccttgg agtgataata     1800

ttgtttccct cgtccgtctg tctcgatgcc tgattcggac ggccaatggt gcttccccca     1860

cccctccacg tgtccgtcca cccttccatc agcgggtctc ctcccagcgg cctccggcgt     1920

cttgcccagc agctcaagaa gaaaaagaag gactgaactc catcgccatc ttcttccctt     1980

aactccaaga acttgggata agagtgtgag agagactgat ggggtcgctc tttgggggaa     2040

acgggctcct tcccctgcac ctggcctggg ccacacctga gcgctgtgga ctgtcctgag     2100

gagccctgag gacctctcag catagcctgc ctgatccctg aacccctggc cagctctgag     2160

gggaggcacc tccaggcagg ccaggctgcc tcggactcca tggctaagac cacagacggg     2220

cacacagact ggagaaaacc cctcccacgg tgcccaaaca ccagtcacct cgtctccctg     2280

gtgcctctgt gcacagtggc ttcttttcgt tttcgttttg aagacgtgga ctcctcttgg     2340

tgggtgtggc cagcacacca agtggctggg tgccctctca ggtgggttag agatggagtt     2400

tgctgttgag gtggctgtag atggtgacct gggtatcccc tgcctcctgc caccccttcc     2460

tccccacact ccactctgat tcacctcttc ctctggttcc tttcatctct ctacctccac     2520

cctgcatttt cctcttgtcc tggcccttca gtctgctcca ccaaggggct cttgaacccc     2580

ttattaaggc cccagatgat cccagtcact cctctctagg gcagaagact agaggccagg     2640

gcagcaaggg acctgctcat catattccaa cccagccacg actgccatgt aaggttgtgc     2700

agggtgtgta ctgcacaagg acattgtatg cagggagcac tgttcacatc atagataaag     2760

ctgatttgta tatttattat gacaatttct ggcagatgta ggtaaagagg aaaaggatcc     2820

ttttcctaat tcacacaaag actccttgtg gactggctgt gcccctgatg cagcctgtgg     2880

cttggagtgg ccaaatagga gggagactgt ggtaggggca gggaggcaac actgctgtcc     2940

acatgacctc catttcccaa agtcctctgc tccagcaact gcccttccag gtgggtgtgg     3000

gacacctggg agaaggtctc caagggaggg tgcagccctc ttgcccgcac ccctccctgc     3060

ttgcacactt ccccatcttt gatccttctg agctccacct ctggtggctc ctcctaggaa     3120

accagctcgt gggctgggaa tgggggagag aagggaaaag atccccaaga ccccctgggg     3180

tgggatctga gctcccacct cccttcccac ctactgcact ttcccccttc ccgccttcca     3240

aaacctgctt ccttcagttt gtaaagtcgg tgattatatt tttgggggct ttccttttat     3300

tttttaaatg taaaatttat ttatattccg tatttaaagt tgtaaaaaaa aataaccaca     3360

aaacaaaacc aaatgaaaaa aaaaaaaaaa aaa                                  3393


<210> 58
<211> 241
<212> PRT
<213> Homo sapiens

<400> 58
Met Asn Arg Cys Trp Ala Leu Phe Leu Ser Leu Cys Cys Tyr Leu Arg 
1               5                   10                  15      


Leu Val Ser Ala Glu Gly Asp Pro Ile Pro Glu Glu Leu Tyr Glu Met 
            20                  25                  30          


Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn Met 
    50                  55                  60                  


Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly Arg 
65                  70                  75                  80  


Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala Glu 
                85                  90                  95      


Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp 
            100                 105                 110         


Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln 
        115                 120                 125             


Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro Thr 
    130                 135                 140                 


Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg 
145                 150                 155                 160 


Lys Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu 
                165                 170                 175     


Ala Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr Arg Ser 
            180                 185                 190         


Pro Gly Gly Ser Gln Glu Gln Arg Ala Lys Thr Pro Gln Thr Arg Val 
        195                 200                 205             


Thr Ile Arg Thr Val Arg Val Arg Arg Pro Pro Lys Gly Lys His Arg 
    210                 215                 220                 


Lys Phe Lys His Thr His Asp Lys Thr Ala Leu Lys Glu Thr Leu Gly 
225                 230                 235                 240 


Ala 
    


<210> 59
<211> 1149
<212> DNA
<213> Homo sapiens

<400> 59
aacaagggag gtgctgcagt tggcggtcgg gctagagaag agaggcgcct gcgcttgcga       60

gctgggcttg tgagtggggc tgccgagagg gcaggcgtgg ggcgaggcca aaggactgaa      120

cccgcaggag cgtcacgggc gccggggcgg ctgccgacgg cgggactggg ttttctatca      180

gatgttccac gtaataatgc tggagttaag aagtttccat tattttgctc caaaccagaa      240

gactctgttc cctgtatata gaataggagt aatatttgaa aacaactggc tgatgtttaa      300

aactgaagat tgtcatgatt gtttatccta atcccaatgc tgaagtaaga ttgtcttgga      360

aatactaagt tggggtaatc caaatctatt tctggaacca tgaaaatttt gctagttttt      420

gactttgaca atacaatcat agatgacaat agtgacactt ggattgtaca atgtgctccc      480

aacaaaaagc ttcctattga actacgtgat tcttatcgaa aaggattttg gacagaattt      540

atgggcagag tctttaagta tttgggagat aagggtgtaa gagaacatga aatgaaaaga      600

gcagtgacat cattgccttt cactccaggg atggtggaac tcttcaactt tataagaaag      660

aataaggata aatttgactg cattattatt tcagattcaa attcggtctt catagattgg      720

gttttagaag ctgccagttt tcatgacata tttgataaag tgtttacaaa tccagcagct      780

tttaatagca atggtcatct cactgttgaa aattatcata ctcattcttg caatagatgc      840

ccaaagaatc tttgcaaaaa ggtagttttg atagaatttg tagataaaca gttacaacag      900

ggagtgaatt atacacaaat tgtttatatt ggtgatggtg gaaatgatgt ctgtccagtc      960

acctttttaa agaatgatga tgttgccatg ccacggaaag gatatacctt acagaaaact     1020

ctttccagaa tgtctcaaaa tcttgagcct atggaatatt ctgttgtagt ttggtcctca     1080

ggtgttgata taatttctca tttacaattt ctaataaagg attaatatgt cagcaaaaaa     1140

aaaaaaaaa                                                             1149


<210> 60
<211> 241
<212> PRT
<213> Homo sapiens

<400> 60
Met Lys Ile Leu Leu Val Phe Asp Phe Asp Asn Thr Ile Ile Asp Asp 
1               5                   10                  15      


Asn Ser Asp Thr Trp Ile Val Gln Cys Ala Pro Asn Lys Lys Leu Pro 
            20                  25                  30          


Ile Glu Leu Arg Asp Ser Tyr Arg Lys Gly Phe Trp Thr Glu Phe Met 
        35                  40                  45              


Gly Arg Val Phe Lys Tyr Leu Gly Asp Lys Gly Val Arg Glu His Glu 
    50                  55                  60                  


Met Lys Arg Ala Val Thr Ser Leu Pro Phe Thr Pro Gly Met Val Glu 
65                  70                  75                  80  


Leu Phe Asn Phe Ile Arg Lys Asn Lys Asp Lys Phe Asp Cys Ile Ile 
                85                  90                  95      


Ile Ser Asp Ser Asn Ser Val Phe Ile Asp Trp Val Leu Glu Ala Ala 
            100                 105                 110         


Ser Phe His Asp Ile Phe Asp Lys Val Phe Thr Asn Pro Ala Ala Phe 
        115                 120                 125             


Asn Ser Asn Gly His Leu Thr Val Glu Asn Tyr His Thr His Ser Cys 
    130                 135                 140                 


Asn Arg Cys Pro Lys Asn Leu Cys Lys Lys Val Val Leu Ile Glu Phe 
145                 150                 155                 160 


Val Asp Lys Gln Leu Gln Gln Gly Val Asn Tyr Thr Gln Ile Val Tyr 
                165                 170                 175     


Ile Gly Asp Gly Gly Asn Asp Val Cys Pro Val Thr Phe Leu Lys Asn 
            180                 185                 190         


Asp Asp Val Ala Met Pro Arg Lys Gly Tyr Thr Leu Gln Lys Thr Leu 
        195                 200                 205             


Ser Arg Met Ser Gln Asn Leu Glu Pro Met Glu Tyr Ser Val Val Val 
    210                 215                 220                 


Trp Ser Ser Gly Val Asp Ile Ile Ser His Leu Gln Phe Leu Ile Lys 
225                 230                 235                 240 


Asp 
    


<210> 61
<211> 678
<212> DNA
<213> Homo sapiens

<400> 61
ctcgcccaaa gaagactaca atctccaggg aaacctgggg cgtctcgcgc aaacgtccat       60

aactgaaagt agctaaggca ccccagccgg aggaagtgag ctctcctggg gcgtggttgt      120

tcgtgatcct tgcatctgtt acttagggtc aaggcttggg tcttgccccg cagacccttg      180

ggacgacccg gccccagcgc agctatgaac ctggagcgag tgtccaatga ggagaaattg      240

aacctgtgcc ggaagtacta cctggggggg tttgctttcc tgccttttct ctggttggtc      300

aacatcttct ggttcttccg agaggccttc cttgtcccag cctacacaga acagagccaa      360

atcaaaggct atgtctggcg ctcagctgtg ggcttcctct tctgggtgat agtgctcacc      420

tcctggatca ccatcttcca gatctaccgg ccccgctggg gtgcccttgg ggactacctc      480

tccttcacca tacccctggg caccccctga caacttctgc acatactggg gccctgctta      540

ttctcccagg acaggctcct taaagcagag gagcctgtcc tgggagcccc ttctcaaact      600

cctaagactt gttttcatgt cccacgttct ctgctgacat cccccaataa aggaccctaa      660

ctttcaaaaa aaaaaaaa                                                    678


<210> 62
<211> 101
<212> PRT
<213> Homo sapiens

<400> 62
Met Asn Leu Glu Arg Val Ser Asn Glu Glu Lys Leu Asn Leu Cys Arg 
1               5                   10                  15      


Lys Tyr Tyr Leu Gly Gly Phe Ala Phe Leu Pro Phe Leu Trp Leu Val 
            20                  25                  30          


Asn Ile Phe Trp Phe Phe Arg Glu Ala Phe Leu Val Pro Ala Tyr Thr 
        35                  40                  45              


Glu Gln Ser Gln Ile Lys Gly Tyr Val Trp Arg Ser Ala Val Gly Phe 
    50                  55                  60                  


Leu Phe Trp Val Ile Val Leu Thr Ser Trp Ile Thr Ile Phe Gln Ile 
65                  70                  75                  80  


Tyr Arg Pro Arg Trp Gly Ala Leu Gly Asp Tyr Leu Ser Phe Thr Ile 
                85                  90                  95      


Pro Leu Gly Thr Pro 
            100     


<210> 63
<211> 5556
<212> DNA
<213> Homo sapiens

<400> 63
tttctcgctc gctcccgttc cccggacgcg gcggatgagc cggccccgct ggggaaggct       60

ccgggcggcg gcgggcggcc gggaggaggc tgcgtgctcg gggctggggc tgcgagcggg      120

gtgattttgt attaaaatga ggaggaggaa gaagaggcac ccacagcggc agcggcggcg      180

gcggcggcag cagcagcagg agcagcggcg gagagggctg cagcccgggc ggacgcgcgg      240

agccgagcgg ggcacggcgg cggcagcgac agcggccggg atgagtcaac taataattta      300

atgggggcag agacggcagc gaggggtaga gctagcgagg gagagagcga gagaagcagc      360

cccgtccggg gactcgcgct cacactcacg cacacacaca aacacacaca cacctctccc      420

tgtgccaccc agcaacaccc ggcctcgtca caacaacaac agccgcggcc gccctctatc      480

ctgcccgggg gcccagccga aagccagggc gactctagag gacgctgccc gcccccctct      540

ttcatttcgg gaaactcctg atcagttttg tcggggtttc tgggtttctt ttcccccaaa      600

gtcctagtgc cattgtggtg ctcgttgttt acctcggact ctggacgagt gagagcttgg      660

cgactttttg gggggagggg gcggggagtt tgtcgctgcc taggcggtgg aggtggctgg      720

gggtgccttc tgatcttcct cctcctcccc ctccccccga acctcttctc tcctcacttg      780

ctgggacccc agacgctcac agccccgcgt caatgggcag ggagagggtc cttgcggctg      840

ttgtcagcga gggcagaatc aaaagtggca ttttagtgcc tttccggggc ttttctcgcg      900

accccctgcc ccccaccctc gctgtccccc gctagatgcc ctcgttgggg gtgcgaggct      960

gtggggaaaa gtttaaggtt tgttaatatt agtcgcgatt gttggcgagg ggggtggggg     1020

tgattggaag ggaggcgagg tggccttccc aatgcgcgtt attcggggtt attgaagaat     1080

aatattgcaa gtgacagcca gaagtagact ttctgtcctc acaccgaaga acccgagtga     1140

gcaggaggga gggagagacg cgaagagacc ttttttcctt tttggagacc ttgtccgcag     1200

tgattttttt ttttttaaga gaatcctcag tcaccacgtc gtttccccag caccatcaca     1260

gtgtacagct cataacgggt tttgctttgt ttttacgatt tccccccaac gaatcacttg     1320

tcagatcaat tttatcttct tcctcctccc tgcttcccac tctcccctcc tccccatcgc     1380

aaaccctgtt ctctgaggtt agacatttta caaaccccta tatgttggtt ttcgaattgt     1440

gatttttttt ttaaacccct ttctcatggc tactcttcta gacgtttatt tctgcccttc     1500

ccccgcttag gggggcgggg gtaggggaaa ggaaaataat acaatttcag gggaagtcgc     1560

cttcaggtct gctgcttttt tatttttttt tttttaatta aaaaaaaaaa ggacatagaa     1620

aacatcagtc ttgaacttct cttcaagaac ccgggctgca aaggaaatct cctttgtttt     1680

tgttatttat gtgctgtcaa gttttgaagt ggtgatcttt agacagtgac tgagtatgga     1740

tcatttgaac gaggcaactc aggggaaaga acattcagaa atgtctaaca atgtgagtga     1800

tccgaagggt ccaccagcca agattgcccg cctggagcag aacgggagcc cgctaggaag     1860

aggaaggctt gggagtacag gtgcaaaaat gcagggagtg cctttaaaac actcgggcca     1920

tctgatgaaa accaacctta ggaaaggaac catgctgcca gttttctgtg tggtggaaca     1980

ttatgaaaac gccattgaat atgattgcaa ggaggagcat gcagaatttg tgctggtgag     2040

aaaggatatg cttttcaacc agctgatcga aatggcattg ctgtctctag gttattcaca     2100

tagctctgct gcccaggcca aagggctaat ccaggttgga aagtggaatc cagttccact     2160

gtcttacgtg acagatgccc ctgatgctac agtagcagat atgcttcaag atgtgtatca     2220

tgtggtcaca ttgaaaattc agttacacag ttgccccaaa ctagaagact tgcctcccga     2280

acaatggtcg cacaccacag tgaggaatgc tctgaaggac ttactgaaag atatgaatca     2340

gagttcattg gccaaggagt gccccctttc acagagtatg atttcttcca ttgtgaacag     2400

tacttactat gcaaatgtct cagcagcaaa atgtcaagaa tttggaaggt ggtacaaaca     2460

tttcaagaag acaaaagata tgatggttga aatggatagt ctttctgagc tatcccagca     2520

aggcgccaat catgtcaatt ttggccagca accagttcca gggaacacag ccgagcagcc     2580

tccatcccct gcgcagctct cccatggcag ccagccctct gtccggacac ctcttccaaa     2640

cctgcaccct gggctcgtat caacacctat cagtcctcaa ttggtcaacc agcagctggt     2700

gatggctcag ctgctgaacc agcagtatgc agtgaataga cttttagccc agcagtcctt     2760

aaaccaacaa tacttgaacc accctccccc tgtcagtaga tctatgaata agcctttgga     2820

gcaacaggtt tcgaccaaca cagaggtgtc ttccgaaatc taccagtggg tacgcgatga     2880

actgaaacga gcaggaatct cccaggcggt atttgcacgt gtggctttta acagaactca     2940

gggcttgctt tcagaaatcc tccgaaagga agaggacccc aagactgcat cccagtcttt     3000

gctggtaaac cttcgggcta tgcagaattt cttgcagtta ccggaagctg aaagagaccg     3060

aatataccag gacgaaaggg aaaggagctt gaatgctgcc tcggccatgg gtcctgcccc     3120

cctcatcagc acaccaccca gccgtcctcc ccaggtgaaa acagctacta ttgccactga     3180

aaggaatggg aaaccagaga acaataccat gaacattaat gcttccattt atgatgagat     3240

tcagcaggaa atgaagcgtg ctaaagtgtc tcaagcactg tttgcaaagg ttgcagcaac     3300

caaaagccag ggatggttgt gcgagctgtt acgctggaaa gaagatcctt ctccagaaaa     3360

cagaaccctg tgggagaacc tctccatgat ccgaaggttc ctcagtcttc ctcagccaga     3420

acgtgatgcc atttatgaac aggagagcaa cgcggtgcat caccatggcg acaggccgcc     3480

ccacattatc catgttccag cagagcagat tcagcaacag cagcagcaac agcaacagca     3540

gcagcagcag cagcaggcac cgccgcctcc acagccacag cagcagccac agacaggccc     3600

tcggctcccc ccacggcaac ccacggtggc ctctccagca gagtcagatg aggaaaaccg     3660

acagaagacc cggccacgaa caaaaatttc agtggaagcc ttgggaatcc tccagagttt     3720

catacaagac gtgggcctgt accctgacga agaggccatc cagactctgt ctgcccagct     3780

cgaccttccc aagtacacca tcatcaagtt ctttcagaac cagcggtact atctcaagca     3840

ccacggcaaa ctgaaggaca attccggttt agaggtcgat gtggcagaat ataaagaaga     3900

ggagctgctg aaggatttgg aagagagtgt ccaagataaa aatactaaca cccttttttc     3960

agtgaaacta gaagaagagc tgtcagtgga aggaaacaca gacattaata ctgatttgaa     4020

agactgagat aaaagtattt gtttcgttca acagtgccac tggtatttac taacaaaatg     4080

aaaagtccac cttgtcttct ctcagaaaac ctttgttgtt cattgtttgg ccaatgaatc     4140

ttcaaaaact tgcacaaaca gaaaagttgg aaaaggataa tacagactgc actaaatgtt     4200

ttcctctgtt ttacaaactg cttggcagcc ccaggtgaag catcaaggat tgtttggtat     4260

taaaatttgt gttcacggga tgcaccaaag tgtgtacccc gtaagcatga aaccagtgtt     4320

ttttgttttt tttttagttc ttattccgga gcctcaaaca agcattatac cttctgtgat     4380

tatgatttcc tctcctataa ttatttctgt agcactccac actgatcttt ggaaacttgc     4440

cccttattta aaaaaaaaaa agaaaaaaaa gagtttgtta ctctattgta tgttacaaaa     4500

gaactataga ctgtggaatg cagtttaaag atgacatatg ccaacaaatg ccttgtatta     4560

tatggcactg ccgtaattca aatttgtttt tattttggaa ataaaagttc actgtacttt     4620

tttttcattc tcattgttac atgatttttt aaaaaaagga aaagaaaatg tgaaacacaa     4680

tttagtcctc attatttatt tgtagatcct gcagcatcat gttgtaatta attttttgga     4740

agtttccgtt aaatgtaata ttgcttctct tgttaccata ctgattcttt tctatttata     4800

aatgtatttt gatgggcagt aaaacaaagt gtcttaaaag ttttaaatag agaaaatgtg     4860

ctttacacag ttgcctataa aaagtgctct atgttatcca agcaattcat actataagct     4920

tcactcttat tgttgtatgc aatttttact atcatgcaaa taagcttagg taaataaaac     4980

taatagatca ccttagaaaa ttatgcaatt aatgtgaaaa taattgatgt ttgcaatgtg     5040

tcttcctttg gtttacaatc aattttaaag ctacatctgt ataaaatttc tgtataaagg     5100

tgtatttctt ttttatgagt ttatggctat gaaaacagct attttgttac agctggctgt     5160

ttttataagt gtatcacaat tttctttatg cagaaatgtt ctgactagga gtggttattg     5220

actgtaacta cacaattaaa attgtttgta tcgtatgaca tggtagggtt tgtctgctta     5280

tgtgaagtaa ctaaaggagt caaaggatgg ccctctcatt taggtgcatg ttaataactt     5340

gttatttcac tgattttaaa aagagcaatt gacaagttac ttgaaacact gtaaatttaa     5400

atcacaaaca catgctcatt tttaaatagg tatgaaattt cacaatgaaa ataacctgtt     5460

tggttaacat tttgcttaat aagtagagat aggatggtca aaagactctc cgacaaaaac     5520

aaatccagtc tctagcagtt atgttgttag aatgga                               5556


<210> 64
<211> 763
<212> PRT
<213> Homo sapiens

<400> 64
Met Asp His Leu Asn Glu Ala Thr Gln Gly Lys Glu His Ser Glu Met 
1               5                   10                  15      


Ser Asn Asn Val Ser Asp Pro Lys Gly Pro Pro Ala Lys Ile Ala Arg 
            20                  25                  30          


Leu Glu Gln Asn Gly Ser Pro Leu Gly Arg Gly Arg Leu Gly Ser Thr 
        35                  40                  45              


Gly Ala Lys Met Gln Gly Val Pro Leu Lys His Ser Gly His Leu Met 
    50                  55                  60                  


Lys Thr Asn Leu Arg Lys Gly Thr Met Leu Pro Val Phe Cys Val Val 
65                  70                  75                  80  


Glu His Tyr Glu Asn Ala Ile Glu Tyr Asp Cys Lys Glu Glu His Ala 
                85                  90                  95      


Glu Phe Val Leu Val Arg Lys Asp Met Leu Phe Asn Gln Leu Ile Glu 
            100                 105                 110         


Met Ala Leu Leu Ser Leu Gly Tyr Ser His Ser Ser Ala Ala Gln Ala 
        115                 120                 125             


Lys Gly Leu Ile Gln Val Gly Lys Trp Asn Pro Val Pro Leu Ser Tyr 
    130                 135                 140                 


Val Thr Asp Ala Pro Asp Ala Thr Val Ala Asp Met Leu Gln Asp Val 
145                 150                 155                 160 


Tyr His Val Val Thr Leu Lys Ile Gln Leu His Ser Cys Pro Lys Leu 
                165                 170                 175     


Glu Asp Leu Pro Pro Glu Gln Trp Ser His Thr Thr Val Arg Asn Ala 
            180                 185                 190         


Leu Lys Asp Leu Leu Lys Asp Met Asn Gln Ser Ser Leu Ala Lys Glu 
        195                 200                 205             


Cys Pro Leu Ser Gln Ser Met Ile Ser Ser Ile Val Asn Ser Thr Tyr 
    210                 215                 220                 


Tyr Ala Asn Val Ser Ala Ala Lys Cys Gln Glu Phe Gly Arg Trp Tyr 
225                 230                 235                 240 


Lys His Phe Lys Lys Thr Lys Asp Met Met Val Glu Met Asp Ser Leu 
                245                 250                 255     


Ser Glu Leu Ser Gln Gln Gly Ala Asn His Val Asn Phe Gly Gln Gln 
            260                 265                 270         


Pro Val Pro Gly Asn Thr Ala Glu Gln Pro Pro Ser Pro Ala Gln Leu 
        275                 280                 285             


Ser His Gly Ser Gln Pro Ser Val Arg Thr Pro Leu Pro Asn Leu His 
    290                 295                 300                 


Pro Gly Leu Val Ser Thr Pro Ile Ser Pro Gln Leu Val Asn Gln Gln 
305                 310                 315                 320 


Leu Val Met Ala Gln Leu Leu Asn Gln Gln Tyr Ala Val Asn Arg Leu 
                325                 330                 335     


Leu Ala Gln Gln Ser Leu Asn Gln Gln Tyr Leu Asn His Pro Pro Pro 
            340                 345                 350         


Val Ser Arg Ser Met Asn Lys Pro Leu Glu Gln Gln Val Ser Thr Asn 
        355                 360                 365             


Thr Glu Val Ser Ser Glu Ile Tyr Gln Trp Val Arg Asp Glu Leu Lys 
    370                 375                 380                 


Arg Ala Gly Ile Ser Gln Ala Val Phe Ala Arg Val Ala Phe Asn Arg 
385                 390                 395                 400 


Thr Gln Gly Leu Leu Ser Glu Ile Leu Arg Lys Glu Glu Asp Pro Lys 
                405                 410                 415     


Thr Ala Ser Gln Ser Leu Leu Val Asn Leu Arg Ala Met Gln Asn Phe 
            420                 425                 430         


Leu Gln Leu Pro Glu Ala Glu Arg Asp Arg Ile Tyr Gln Asp Glu Arg 
        435                 440                 445             


Glu Arg Ser Leu Asn Ala Ala Ser Ala Met Gly Pro Ala Pro Leu Ile 
    450                 455                 460                 


Ser Thr Pro Pro Ser Arg Pro Pro Gln Val Lys Thr Ala Thr Ile Ala 
465                 470                 475                 480 


Thr Glu Arg Asn Gly Lys Pro Glu Asn Asn Thr Met Asn Ile Asn Ala 
                485                 490                 495     


Ser Ile Tyr Asp Glu Ile Gln Gln Glu Met Lys Arg Ala Lys Val Ser 
            500                 505                 510         


Gln Ala Leu Phe Ala Lys Val Ala Ala Thr Lys Ser Gln Gly Trp Leu 
        515                 520                 525             


Cys Glu Leu Leu Arg Trp Lys Glu Asp Pro Ser Pro Glu Asn Arg Thr 
    530                 535                 540                 


Leu Trp Glu Asn Leu Ser Met Ile Arg Arg Phe Leu Ser Leu Pro Gln 
545                 550                 555                 560 


Pro Glu Arg Asp Ala Ile Tyr Glu Gln Glu Ser Asn Ala Val His His 
                565                 570                 575     


His Gly Asp Arg Pro Pro His Ile Ile His Val Pro Ala Glu Gln Ile 
            580                 585                 590         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala 
        595                 600                 605             


Pro Pro Pro Pro Gln Pro Gln Gln Gln Pro Gln Thr Gly Pro Arg Leu 
    610                 615                 620                 


Pro Pro Arg Gln Pro Thr Val Ala Ser Pro Ala Glu Ser Asp Glu Glu 
625                 630                 635                 640 


Asn Arg Gln Lys Thr Arg Pro Arg Thr Lys Ile Ser Val Glu Ala Leu 
                645                 650                 655     


Gly Ile Leu Gln Ser Phe Ile Gln Asp Val Gly Leu Tyr Pro Asp Glu 
            660                 665                 670         


Glu Ala Ile Gln Thr Leu Ser Ala Gln Leu Asp Leu Pro Lys Tyr Thr 
        675                 680                 685             


Ile Ile Lys Phe Phe Gln Asn Gln Arg Tyr Tyr Leu Lys His His Gly 
    690                 695                 700                 


Lys Leu Lys Asp Asn Ser Gly Leu Glu Val Asp Val Ala Glu Tyr Lys 
705                 710                 715                 720 


Glu Glu Glu Leu Leu Lys Asp Leu Glu Glu Ser Val Gln Asp Lys Asn 
                725                 730                 735     


Thr Asn Thr Leu Phe Ser Val Lys Leu Glu Glu Glu Leu Ser Val Glu 
            740                 745                 750         


Gly Asn Thr Asp Ile Asn Thr Asp Leu Lys Asp 
        755                 760             


<210> 65
<211> 2315
<212> DNA
<213> Homo sapiens

<400> 65
ccggcgtccc aagtgagtgg aggggggatc ccgactccag tccggggcct tggccagcgg       60

agccgcgcta ttcggaagcg ggaatcccac tcagagcccg ggcctgtagg ggcggggcgt      120

cccgggcacc cgggattggg gcgtctcccg tcgtgcaccg gggcaccggc gactcacccg      180

gaaggagaag ccgtgatctg gctatatggt ggggcgcggg cggtgtcgct gtggggagct      240

ggtgctgttc tcagatgttt ccttccaatg ggcttttggt gtaggatgtc ggagaaccaa      300

gaacaggagg aggtgattac agtgcgtgtt caggaccccc gagtgcagaa tgagggctcc      360

tggaactctt atgtggatta taagatattc ctccatacca acagcaaagc ctttactgcc      420

aagacttcct gtgtgcggcg ccgctaccgt gagttcgtgt ggctgagaaa gcagctacag      480

agaaatgctg gtttggtgcc tgttcctgaa cttcctggga agtcaacctt cttcggcacc      540

tcagatgagt tcattgagaa gcgacgacaa ggtctgcagc acttccttga aaaggtcctg      600

cagagtgtgg ttctcctgtc agacagccag ttgcacctat tcctgcaaag ccagctctcg      660

gtgcctgaga tagaagcctg tgtccagggc cgaagtacca tgactgtgtc tgatgccatt      720

cttcgatatg ctatgtcaaa ctgtggctgg gcccaggaag agaggcagag ctcttctcac      780

ctggctaaag gagaccagcc taagagttgc tgctttcttc caagatcggg taggaggagc      840

tctccctcac cgcctcccag tgaagaaaag gaccatttag aagtgtgggc tccagttgtt      900

gactctgagg ttccttcctt ggaaagtccc actctcccac ccctctcctc accattatgc      960

tgtgattttg gaagacccaa agagggaacc tccactcttc agtctgtgag gagggctgtg     1020

ggaggagatc atgctgtgcc tttggaccct ggtcagttag aaacagtttt ggaaaagtga     1080

gctctgggtt ctgctctgag atggtcagag aagatgcggg ccaggagact tactcaggtg     1140

ggactgggca cagggcaggt atgtgggagg ctgggctgct tagtgtcttc tagtcacctc     1200

tgcttgggct gattgacaga ggtcagtcat tacagcccct tatgcctctt ccatgggaac     1260

aaatactgtg cagatgtttg taagttaaac ataagacaca ggggctgttg cttttgaaca     1320

gaaccctata ttactctcct gggatctgag tttctgcagg tcatttgtat gtaggaccag     1380

gagtatctcc tcaggtgacc agttttgggg acccgtatgt ggcaaattct aagctgccat     1440

attgaacatc atcccactgg gagtggttat gttgtatccc catcttggct ggcttcagtt     1500

tttgctgtag ccctagagca ctttgtttgt gggaggctgg cctcttgcct acctccttgc     1560

atggacaggg ggatgaatat ttactttccc acctccttgc tttttctttc actgatacca     1620

ctgaatggaa ctggtgctgt gactcctgct gctggggatt tatgtcccga gaccttagcc     1680

tggctgagtg gagcctgaga cctgcacaac agctcatggt catgcatgag agagaagtgg     1740

ctggccacag ccagagggaa cagtaacagc ccaggggcct ttattttggg aaaggctgtc     1800

ccgggctgtt actgtctctt ctggttataa agcagacatg tggccatctt ttccgcaggg     1860

ttagagtggg ctcctttctt tttggaatcc ttttcttctc ctttggtagc agctccctgc     1920

ctccagggct tccgccacca gcgtctctgc tgtgttgcgc agtgcagtgg ggtgcaaggg     1980

ctttgtttct gcctgcctga aagagagggc tctggggatg gagatgagaa acaacacgct     2040

ctccttcaga caatgaggca ttctgtcctc ctgctgccat tcttcatctc cactgagagc     2100

cagagctggt aggagccgag tgccacaggc attctgcatt gctctactct taggtttgtg     2160

tgtgtgatcc ttcccctccc tgtcgcccac tcctccctcc tctggctatc ctaccctgtc     2220

tgtgggctct tttactacca gcctatgctg tgggactgtc atggcattta gttcagagtg     2280

gaggggcttt ggcctgaaat aaaatgcaag tattt                                2315


<210> 66
<211> 270
<212> PRT
<213> Homo sapiens

<400> 66
Met Gly Phe Trp Cys Arg Met Ser Glu Asn Gln Glu Gln Glu Glu Val 
1               5                   10                  15      


Ile Thr Val Arg Val Gln Asp Pro Arg Val Gln Asn Glu Gly Ser Trp 
            20                  25                  30          


Asn Ser Tyr Val Asp Tyr Lys Ile Phe Leu His Thr Asn Ser Lys Ala 
        35                  40                  45              


Phe Thr Ala Lys Thr Ser Cys Val Arg Arg Arg Tyr Arg Glu Phe Val 
    50                  55                  60                  


Trp Leu Arg Lys Gln Leu Gln Arg Asn Ala Gly Leu Val Pro Val Pro 
65                  70                  75                  80  


Glu Leu Pro Gly Lys Ser Thr Phe Phe Gly Thr Ser Asp Glu Phe Ile 
                85                  90                  95      


Glu Lys Arg Arg Gln Gly Leu Gln His Phe Leu Glu Lys Val Leu Gln 
            100                 105                 110         


Ser Val Val Leu Leu Ser Asp Ser Gln Leu His Leu Phe Leu Gln Ser 
        115                 120                 125             


Gln Leu Ser Val Pro Glu Ile Glu Ala Cys Val Gln Gly Arg Ser Thr 
    130                 135                 140                 


Met Thr Val Ser Asp Ala Ile Leu Arg Tyr Ala Met Ser Asn Cys Gly 
145                 150                 155                 160 


Trp Ala Gln Glu Glu Arg Gln Ser Ser Ser His Leu Ala Lys Gly Asp 
                165                 170                 175     


Gln Pro Lys Ser Cys Cys Phe Leu Pro Arg Ser Gly Arg Arg Ser Ser 
            180                 185                 190         


Pro Ser Pro Pro Pro Ser Glu Glu Lys Asp His Leu Glu Val Trp Ala 
        195                 200                 205             


Pro Val Val Asp Ser Glu Val Pro Ser Leu Glu Ser Pro Thr Leu Pro 
    210                 215                 220                 


Pro Leu Ser Ser Pro Leu Cys Cys Asp Phe Gly Arg Pro Lys Glu Gly 
225                 230                 235                 240 


Thr Ser Thr Leu Gln Ser Val Arg Arg Ala Val Gly Gly Asp His Ala 
                245                 250                 255     


Val Pro Leu Asp Pro Gly Gln Leu Glu Thr Val Leu Glu Lys 
            260                 265                 270 


<210> 67
<211> 8017
<212> DNA
<213> Homo sapiens

<400> 67
tatgtcttct aaagataatg tcgattgtgt atggctgatg ggattctagg accaagcaag       60

aggttttttt ttttccccca catacttaac gtttctatat ttctatttga attcgactgg      120

acagttccat ttgaattatt tctctctctc tctctctctg acacatttta tcttgccagg      180

ttctaaacct ttaggaaaaa tggagcaatt tccaaaggaa accgttgtgg agagcagtgg      240

gccaaaggtt ttggaaacag cagaagagat ccaggagagg cgtcaggaag tgttgactcg      300

gtatcaaagt ttcaaggagc gggtcgctga gaggggtcag aagcttgagg attcctatca      360

cttacaagtt ttcaagcgag atgcagatga tctggggaag tggatcatgg agaaagtcaa      420

tatcttaacc gataagagct atgaagaccc aactaatata caggggaaat atcagaagca      480

tcaatccctt gaagcagagg tgcaaacaaa atcaagactc atgtctgaac tggaaaaaac      540

aagggaagaa cgatttacca tgggtcattc tgcccacgaa gaaacgaagg cccatataga      600

ggagctacgc cacctgtggg acctgctgtt agagctgacc ctggagaagg gtgaccagtt      660

gctgcgggcc ctgaagttcc agcagtatgt acaggagtgt gctgacatct tagagtggat      720

tggagacaag gaggctatag cgacatcagt ggagctaggt gaagactggg agcgcaccga      780

agttctgcat aagaaatttg aagacttcca agtggagctg gtagctaaag aagggagagt      840

tgttgaagtg aaccaatatg ccaatgagtg tgccgaggaa aaccatcctg acctaccctt      900

aattcagtct aagcaaaatg aggtgaatgc tgcctgggag cgccttcgtg gtttggctct      960

ccagagacag aaagctctgt ccaatgctgc aaacttacaa cgattcaaaa gggatgtgac     1020

tgaagccatc cagtggatca aggagaagga acctgtactc acctctgagg actatggcaa     1080

agaccttgtt gcctctgaag gactgtttca cagtcacaag ggacttgaga gaaatcttgc     1140

tgtcatgagt gacaaggtga aggagttatg tgctaaagca gagaagctga cactttccca     1200

tccttcagat gcacctcaga tccaggagat gaaagaagat ctggtctcca gctgggagca     1260

tattcgtgcc ctggccacca gcagatatga aaaactgcag gctacttatt ggtaccatcg     1320

attttcatct gactttgatg aactctcagg ctggatgaac gagaagactg ctgcgatcaa     1380

tgctgatgag ctgccaacag atgtggctgg tggagaagtt ctgctggaca ggcatcagca     1440

gcataagcat gagattgact cttacgatga ccgatttcaa tctgctgatg agactggtca     1500

agacctcgtg aatgccaatc atgaagcctc tgatgaagtt cgggaaaaga tggaaatact     1560

tgacaacaac tggactgccc tgctggaact gtgggacgag cgtcatcgtc agtatgagca     1620

gtgcttggac tttcatctct tctacagaga cagtgagcaa gtggacagtt ggatgagtag     1680

acaagaggcc ttcctggaaa acgaggatct gggaaactca ctgggcagtg cagaagccct     1740

tcttcagaag catgaagact ttgaggaagc ctttactgcc caggaagaga agatcataac     1800

tgtagacaag actgcaacca aattgattgg tgatgaccat tatgattcag agaacatcaa     1860

ggctatccgt gacgggctgt tagcccggcg ggatgcccta cgtgaaaagg ctgccactag     1920

acgtagattg ctgaaggagt cattgcttct gcaaaaactg tatgaggact cagatgacct     1980

aaagaactgg atcaacaaga agaaaaagtt ggcagatgat gaagattaca aggacataca     2040

gaacttgaag agcagggttc aaaagcagca agtctttgaa aaggagttgg cagttaataa     2100

gacccagctg gaaaacatac agaaaactgg ccaagagatg attgagggtg gtcactatgc     2160

ctctgacaat gtgaccactc gtctgagtga agttgccagc ctctgggagg agttgctgga     2220

ggctacaaaa cagaaaggga cccagttgca tgaggccaac cagcagctgc aatttgaaaa     2280

taatgcagaa gatttgcagc gctggctgga ggatgttgag tggcaagtca cctctgagga     2340

ttatgggaaa ggcctggccg aggtacagaa tcgactcagg aaacacggcc tcctggagtc     2400

ggctgtggct gctcgtcagg atcaggtgga tatccttaca gacctggctg catattttga     2460

agaaataggc catcctgatt ctaaggatat aagggcaagg caagagtcct tggtatgccg     2520

atttgaagct ctgaaagagc cactggccac ccgaaagaag aagctcttag accttctcca     2580

tctgcagctg atttgtagag acacagagga tgaggaggcc tggatccaag agactgaacc     2640

ctcagctact tccacctacc ttggaaagga cctgattgct tccaaaaagc ttctgaatag     2700

gcatagagtc atcctggaga acattgccag ccatgaacca cgcattcaag agataacaga     2760

aaggggaaac aaaatggtag aggaaggaca ctttgctgca gaagatgtgg cctctagggt     2820

caagagtttg aaccagaata tggagtctct ccgtgctcga gctgctaggc gacaaaatga     2880

tcttgaagcc aatgtccagt tccagcagta cctggctgac ctgcatgaag cagaaacatg     2940

gatcagagag aaggaaccta ttgtagataa tactaactat ggtgctgatg aagaagcagc     3000

tggggctctt ctaaagaagc atgaggcctt tctattagat ctcaattcat ttggagacag     3060

tatgaaagct ctgcggaatc aggcaaacgc ctgccagcaa caacaggctg caccagtgga     3120

gggagttgct ggagaacaaa gggtcatggc tttatatgac ttccaggccc gcagcccccg     3180

agaagtcacc atgaagaaag gtgatgtctt aacgctgctc agttccatca ataaggactg     3240

gtggaaggtg gaagctgctg atcatcaggg cattgtccca gctgtctatg tcagaagact     3300

ggcccacgat gagttcccga tgctcccaca gcggcgacga gaagagccag gaaacatcac     3360

ccagcgccag gagcagattg agaaccaata ccgctccctc ttggatcggg cagaagaacg     3420

cagacgtcgt ctattgcaac gttataatga atttttattg gcctatgagg caggagacat     3480

gctggaatgg attcaagaga aaaaggcaga aaacactgga gtggaactag atgatgtttg     3540

ggagctgcag aaaaagtttg atgagttcca aaaggatttg aataccaatg agcctcggct     3600

aagggatatc aacaaggtag ctgatgatct actatttgaa ggacttctaa caccagaagg     3660

agctcaaatc cggcaggaat tgaattcccg ctggggttct ttgcagaggc ttgcagatga     3720

acagcggcag ctgctgggca gtgcccatgc tgttgaagtg tttcacagag aagcagatga     3780

cacgaaggag cagattgaga agaaatgcca ggccctcagt gctgcagacc ctggctcaga     3840

tctgttcagt gttcaggctc ttcagcgacg gcatgagggc tttgaaaggg acctcgtacc     3900

cctgggagat aaggtgacca tactggggga gacagcagag cggctcagtg agtcccatcc     3960

agatgccact gaggacctgc agagacagaa aatggagctg aatgaggcct gggaagacct     4020

gcaggggcgt acaaaggatc gtaaggagag cctaaatgag gcccagaaat tctacctgtt     4080

cctcagcaag gccagggatc tgcagaactg gatcagtagc attggtggca tggtatcatc     4140

acaggagctg gccgaagact taactggcat agagatcttg ctggagagac atcaggagca     4200

ccgtgctgac atggaggcag aggctcccac cttccaggcc ttagaggact tcagtgcaga     4260

acttatcgac agtgggcacc atgctagccc tgaaattgaa aaaaagcttc aagctgtcaa     4320

gctagagaga gatgatttgg agaaggcttg ggaaaaacgc aagaagatcc tagaccagtg     4380

cctggagttg cagatgttcc aggggaactg tgatcaagtt gagagctgga tggtggcacg     4440

tgagaattcc ctgaggtcag atgacaaaag ttccttagac agtctggagg ctttgatgaa     4500

gaaacgggac gatttggaca aagcaatcac tgcccaggaa gggaagatca ctgacctaga     4560

acattttgct gagagcctca ttgctgatga acactatgcc aaagaagaga ttgctacgcg     4620

gctccaacgt gtactagaca ggtggaaggc tctcaaagca caactgattg atgagcggac     4680

aaagcttgga gactatgcca acctaaaaca attctaccga gaccttgagg agctggaaga     4740

atggatcagt gagatgctgc ccacagcctg tgatgaatcc tacaaagacg ccactaacat     4800

tcagaggaaa tacctgaaac accagacctt tgcacatgaa gtcgatggcc gatctgagca     4860

ggtgcatggc gtcatcaacc tggggaactc cctgattgag tgtagcgctt gtgatggcaa     4920

tgaagaggcc atgaaggagc aactggaaca gctgaaggaa cattgggatc atctgcttga     4980

gagaacaaat gacaaaggga agaagctcaa tgaggccagt cgtcaacaga ggttcaacac     5040

aagcatccgg gactttgagt tctggctctc agaggcagag acattgctgg ccatgaaaga     5100

tcaggccagg gacttggctt cagcaggaaa cctactcaag aagcatcagc tattggagag     5160

agagatgttg gctcgagagg atgcactcaa ggacctgaat acattggctg aagatttgct     5220

ctccagcggg actttcaacg ttgatcagat tgtgaagaaa aaagataatg tcaacaagcg     5280

tttcctgaat gtccaagaat tggcagctgc acaccacgaa aaattgaaag aggcctatgc     5340

cttgttccag ttcttccagg atctagatga tgaggaatcc tggatagagg agaagttgat     5400

acgagtgagc tcccaggact atgggagaga tcttcagggg gttcagaact tgctgaagaa     5460

gcacaaacgc ctagaggggg agctggtggc ccatgagcct gccatccaga atgtgctgga     5520

tatggcagag aagctgaaag acaaggctgc tgtggggcaa gaggagatcc agttgcggct     5580

ggctcagttt gttgaacact gggagaagct caaagagttg gccaaggccc gaggacttaa     5640

gttggaagaa tccctagaat acttgcaatt catgcagaat gctgaggaag aggaagcttg     5700

gatcaatgaa aagaatgctt tggctgtccg aggagattgt ggagatacat tagctgctac     5760

tcagagcttg ctaatgaagc atgaagcttt ggaaaatgac tttgctgtcc atgagacccg     5820

agtacaaaat gtgtgtgcac aaggagaaga catcctaaat aaggtgttgc aggaggaaag     5880

tcagaacaaa gagatttctt ccaagataga ggctctgaat gaaaagaccc cttctctggc     5940

taaggcaata gctgcttgga agttgcaatt ggaagacgat tatgcctttc aggaattcaa     6000

ctggaaggct gatgtggtag aggcttggat agctgataag gaaacaagcc taaagaccaa     6060

tggcaatggt gcagaccttg gtgacttcct cactcttctg gcaaaacagg acactctgga     6120

tgccagtctg cagagtttcc agcaagagag acttcccgag atcactgacc tgaaggacaa     6180

actgatttct gctcaacaca accagtctaa agccattgaa gagcgttatg ccgctctgct     6240

gaagcgctgg gaacagttgc tggaagcctc ggcagtccac agacagaaat tgctggagaa     6300

acagctgcct ctacagaagg ctgaggacct gttcgtggaa tttgcacata aggcttcagc     6360

tttgaacaac tggtgtgaaa agatggaaga aaacttgtca gagcctgtgc actgtgtctc     6420

cctgaatgaa attcggcagc tgcagaaaga ccatgaggac ttcttggcct ccctggctag     6480

ggctcaagca gactttaaat gtttgctgga gctagaccag cagattaagg ccttaggtgt     6540

gccttccagc ccttatacct ggttaacagt ggaggtgctg gaaaggacct ggaagcacct     6600

atctgacatc attgaggaac gggagcagga gctgcaaaag gaagaggcaa gacaggtcaa     6660

gaactttgag atgtgtcagg agtttgaaca gaatgccagt accttccttc aatggatcct     6720

ggaaaccagg gcttactttc tggatggatc attgctcaaa gaaacaggaa ctctggaatc     6780

tcagctggaa gcaaataaaa gaaaacagaa ggagatccag gcgatgaagc gtcaactaac     6840

caagattgtg gacctggggg acaacttgga agacgctctg atccttgata tcaaatacag     6900

caccattgga ttggctcagc agtgggacca gctctaccag cttgggttgc ggatgcaaca     6960

caacctggag caacagatcc aggccaagga catcaaaggt gtgagtgaag agactctaaa     7020

ggaatttagc acaatctata aacactttga tgagaatttg acagggcgcc tgactcacaa     7080

agagttccgg tcctgcctga gaggactcaa ttactacttg cccatggtgg aggaggatga     7140

acatgagccc aagtttgaga agttcctgga tgctgtggat ccagggagga agggctatgt     7200

ctcactggag gactatactg ctttcctgat tgacaaggag tcagaaaaca tcaagtccag     7260

tgatgaaata gagaatgcct tccaagccct ggcagagggc aagtcatata ttaccaaaga     7320

agacatgaag caggccctta ccccagagca agtgtcattc tgtgccacac atatgcagca     7380

atatatggac ccacggggtc gaagccatct ctctggctat gactacgttg gcttcaccaa     7440

ttcctacttt ggcaactaat aagcagctcc tcgtggatcg tagaaaatct tagtgtcgtg     7500

ggaaatttac tggggggcaa agagtacagg caaatgtgga agataaagat ggcctcgtgt     7560

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gcttgtgttt gtgtgcatat tacatttatt     7620

gtaggatctt aaaaaatctc aagggtggga gatagaaagg ttaatagagt tggaggagtg     7680

gaagctattt tgtatgcaac tagtcactgc tgaggggtgt caaagtttct atttttattt     7740

gttctgtttt gcacgtcttt atcattttgc tttattccga ttatagaata aagtaattct     7800

ttttaaaaat attttttggg gcaaagttaa gtaaaatgtt gagcttctat atttctggga     7860

actgtactca tataagagtg ggcagctaat tttactgtaa agaagggcca tggtatagta     7920

gataaataaa atccaaggca attttcaaac aattttttta aactttggaa tgtgtttaaa     7980

tttaaatttg aaaataaaga tatttgattt tctgggg                              8017


<210> 68
<211> 2419
<212> PRT
<213> Homo sapiens

<400> 68
Met Glu Gln Phe Pro Lys Glu Thr Val Val Glu Ser Ser Gly Pro Lys 
1               5                   10                  15      


Val Leu Glu Thr Ala Glu Glu Ile Gln Glu Arg Arg Gln Glu Val Leu 
            20                  25                  30          


Thr Arg Tyr Gln Ser Phe Lys Glu Arg Val Ala Glu Arg Gly Gln Lys 
        35                  40                  45              


Leu Glu Asp Ser Tyr His Leu Gln Val Phe Lys Arg Asp Ala Asp Asp 
    50                  55                  60                  


Leu Gly Lys Trp Ile Met Glu Lys Val Asn Ile Leu Thr Asp Lys Ser 
65                  70                  75                  80  


Tyr Glu Asp Pro Thr Asn Ile Gln Gly Lys Tyr Gln Lys His Gln Ser 
                85                  90                  95      


Leu Glu Ala Glu Val Gln Thr Lys Ser Arg Leu Met Ser Glu Leu Glu 
            100                 105                 110         


Lys Thr Arg Glu Glu Arg Phe Thr Met Gly His Ser Ala His Glu Glu 
        115                 120                 125             


Thr Lys Ala His Ile Glu Glu Leu Arg His Leu Trp Asp Leu Leu Leu 
    130                 135                 140                 


Glu Leu Thr Leu Glu Lys Gly Asp Gln Leu Leu Arg Ala Leu Lys Phe 
145                 150                 155                 160 


Gln Gln Tyr Val Gln Glu Cys Ala Asp Ile Leu Glu Trp Ile Gly Asp 
                165                 170                 175     


Lys Glu Ala Ile Ala Thr Ser Val Glu Leu Gly Glu Asp Trp Glu Arg 
            180                 185                 190         


Thr Glu Val Leu His Lys Lys Phe Glu Asp Phe Gln Val Glu Leu Val 
        195                 200                 205             


Ala Lys Glu Gly Arg Val Val Glu Val Asn Gln Tyr Ala Asn Glu Cys 
    210                 215                 220                 


Ala Glu Glu Asn His Pro Asp Leu Pro Leu Ile Gln Ser Lys Gln Asn 
225                 230                 235                 240 


Glu Val Asn Ala Ala Trp Glu Arg Leu Arg Gly Leu Ala Leu Gln Arg 
                245                 250                 255     


Gln Lys Ala Leu Ser Asn Ala Ala Asn Leu Gln Arg Phe Lys Arg Asp 
            260                 265                 270         


Val Thr Glu Ala Ile Gln Trp Ile Lys Glu Lys Glu Pro Val Leu Thr 
        275                 280                 285             


Ser Glu Asp Tyr Gly Lys Asp Leu Val Ala Ser Glu Gly Leu Phe His 
    290                 295                 300                 


Ser His Lys Gly Leu Glu Arg Asn Leu Ala Val Met Ser Asp Lys Val 
305                 310                 315                 320 


Lys Glu Leu Cys Ala Lys Ala Glu Lys Leu Thr Leu Ser His Pro Ser 
                325                 330                 335     


Asp Ala Pro Gln Ile Gln Glu Met Lys Glu Asp Leu Val Ser Ser Trp 
            340                 345                 350         


Glu His Ile Arg Ala Leu Ala Thr Ser Arg Tyr Glu Lys Leu Gln Ala 
        355                 360                 365             


Thr Tyr Trp Tyr His Arg Phe Ser Ser Asp Phe Asp Glu Leu Ser Gly 
    370                 375                 380                 


Trp Met Asn Glu Lys Thr Ala Ala Ile Asn Ala Asp Glu Leu Pro Thr 
385                 390                 395                 400 


Asp Val Ala Gly Gly Glu Val Leu Leu Asp Arg His Gln Gln His Lys 
                405                 410                 415     


His Glu Ile Asp Ser Tyr Asp Asp Arg Phe Gln Ser Ala Asp Glu Thr 
            420                 425                 430         


Gly Gln Asp Leu Val Asn Ala Asn His Glu Ala Ser Asp Glu Val Arg 
        435                 440                 445             


Glu Lys Met Glu Ile Leu Asp Asn Asn Trp Thr Ala Leu Leu Glu Leu 
    450                 455                 460                 


Trp Asp Glu Arg His Arg Gln Tyr Glu Gln Cys Leu Asp Phe His Leu 
465                 470                 475                 480 


Phe Tyr Arg Asp Ser Glu Gln Val Asp Ser Trp Met Ser Arg Gln Glu 
                485                 490                 495     


Ala Phe Leu Glu Asn Glu Asp Leu Gly Asn Ser Leu Gly Ser Ala Glu 
            500                 505                 510         


Ala Leu Leu Gln Lys His Glu Asp Phe Glu Glu Ala Phe Thr Ala Gln 
        515                 520                 525             


Glu Glu Lys Ile Ile Thr Val Asp Lys Thr Ala Thr Lys Leu Ile Gly 
    530                 535                 540                 


Asp Asp His Tyr Asp Ser Glu Asn Ile Lys Ala Ile Arg Asp Gly Leu 
545                 550                 555                 560 


Leu Ala Arg Arg Asp Ala Leu Arg Glu Lys Ala Ala Thr Arg Arg Arg 
                565                 570                 575     


Leu Leu Lys Glu Ser Leu Leu Leu Gln Lys Leu Tyr Glu Asp Ser Asp 
            580                 585                 590         


Asp Leu Lys Asn Trp Ile Asn Lys Lys Lys Lys Leu Ala Asp Asp Glu 
        595                 600                 605             


Asp Tyr Lys Asp Ile Gln Asn Leu Lys Ser Arg Val Gln Lys Gln Gln 
    610                 615                 620                 


Val Phe Glu Lys Glu Leu Ala Val Asn Lys Thr Gln Leu Glu Asn Ile 
625                 630                 635                 640 


Gln Lys Thr Gly Gln Glu Met Ile Glu Gly Gly His Tyr Ala Ser Asp 
                645                 650                 655     


Asn Val Thr Thr Arg Leu Ser Glu Val Ala Ser Leu Trp Glu Glu Leu 
            660                 665                 670         


Leu Glu Ala Thr Lys Gln Lys Gly Thr Gln Leu His Glu Ala Asn Gln 
        675                 680                 685             


Gln Leu Gln Phe Glu Asn Asn Ala Glu Asp Leu Gln Arg Trp Leu Glu 
    690                 695                 700                 


Asp Val Glu Trp Gln Val Thr Ser Glu Asp Tyr Gly Lys Gly Leu Ala 
705                 710                 715                 720 


Glu Val Gln Asn Arg Leu Arg Lys His Gly Leu Leu Glu Ser Ala Val 
                725                 730                 735     


Ala Ala Arg Gln Asp Gln Val Asp Ile Leu Thr Asp Leu Ala Ala Tyr 
            740                 745                 750         


Phe Glu Glu Ile Gly His Pro Asp Ser Lys Asp Ile Arg Ala Arg Gln 
        755                 760                 765             


Glu Ser Leu Val Cys Arg Phe Glu Ala Leu Lys Glu Pro Leu Ala Thr 
    770                 775                 780                 


Arg Lys Lys Lys Leu Leu Asp Leu Leu His Leu Gln Leu Ile Cys Arg 
785                 790                 795                 800 


Asp Thr Glu Asp Glu Glu Ala Trp Ile Gln Glu Thr Glu Pro Ser Ala 
                805                 810                 815     


Thr Ser Thr Tyr Leu Gly Lys Asp Leu Ile Ala Ser Lys Lys Leu Leu 
            820                 825                 830         


Asn Arg His Arg Val Ile Leu Glu Asn Ile Ala Ser His Glu Pro Arg 
        835                 840                 845             


Ile Gln Glu Ile Thr Glu Arg Gly Asn Lys Met Val Glu Glu Gly His 
    850                 855                 860                 


Phe Ala Ala Glu Asp Val Ala Ser Arg Val Lys Ser Leu Asn Gln Asn 
865                 870                 875                 880 


Met Glu Ser Leu Arg Ala Arg Ala Ala Arg Arg Gln Asn Asp Leu Glu 
                885                 890                 895     


Ala Asn Val Gln Phe Gln Gln Tyr Leu Ala Asp Leu His Glu Ala Glu 
            900                 905                 910         


Thr Trp Ile Arg Glu Lys Glu Pro Ile Val Asp Asn Thr Asn Tyr Gly 
        915                 920                 925             


Ala Asp Glu Glu Ala Ala Gly Ala Leu Leu Lys Lys His Glu Ala Phe 
    930                 935                 940                 


Leu Leu Asp Leu Asn Ser Phe Gly Asp Ser Met Lys Ala Leu Arg Asn 
945                 950                 955                 960 


Gln Ala Asn Ala Cys Gln Gln Gln Gln Ala Ala Pro Val Glu Gly Val 
                965                 970                 975     


Ala Gly Glu Gln Arg Val Met Ala Leu Tyr Asp Phe Gln Ala Arg Ser 
            980                 985                 990         


Pro Arg Glu Val Thr Met Lys Lys  Gly Asp Val Leu Thr  Leu Leu Ser 
        995                 1000                 1005             


Ser Ile  Asn Lys Asp Trp Trp  Lys Val Glu Ala Ala  Asp His Gln 
    1010                 1015                 1020             


Gly Ile  Val Pro Ala Val Tyr  Val Arg Arg Leu Ala  His Asp Glu 
    1025                 1030                 1035             


Phe Pro  Met Leu Pro Gln Arg  Arg Arg Glu Glu Pro  Gly Asn Ile 
    1040                 1045                 1050             


Thr Gln  Arg Gln Glu Gln Ile  Glu Asn Gln Tyr Arg  Ser Leu Leu 
    1055                 1060                 1065             


Asp Arg  Ala Glu Glu Arg Arg  Arg Arg Leu Leu Gln  Arg Tyr Asn 
    1070                 1075                 1080             


Glu Phe  Leu Leu Ala Tyr Glu  Ala Gly Asp Met Leu  Glu Trp Ile 
    1085                 1090                 1095             


Gln Glu  Lys Lys Ala Glu Asn  Thr Gly Val Glu Leu  Asp Asp Val 
    1100                 1105                 1110             


Trp Glu  Leu Gln Lys Lys Phe  Asp Glu Phe Gln Lys  Asp Leu Asn 
    1115                 1120                 1125             


Thr Asn  Glu Pro Arg Leu Arg  Asp Ile Asn Lys Val  Ala Asp Asp 
    1130                 1135                 1140             


Leu Leu  Phe Glu Gly Leu Leu  Thr Pro Glu Gly Ala  Gln Ile Arg 
    1145                 1150                 1155             


Gln Glu  Leu Asn Ser Arg Trp  Gly Ser Leu Gln Arg  Leu Ala Asp 
    1160                 1165                 1170             


Glu Gln  Arg Gln Leu Leu Gly  Ser Ala His Ala Val  Glu Val Phe 
    1175                 1180                 1185             


His Arg  Glu Ala Asp Asp Thr  Lys Glu Gln Ile Glu  Lys Lys Cys 
    1190                 1195                 1200             


Gln Ala  Leu Ser Ala Ala Asp  Pro Gly Ser Asp Leu  Phe Ser Val 
    1205                 1210                 1215             


Gln Ala  Leu Gln Arg Arg His  Glu Gly Phe Glu Arg  Asp Leu Val 
    1220                 1225                 1230             


Pro Leu  Gly Asp Lys Val Thr  Ile Leu Gly Glu Thr  Ala Glu Arg 
    1235                 1240                 1245             


Leu Ser  Glu Ser His Pro Asp  Ala Thr Glu Asp Leu  Gln Arg Gln 
    1250                 1255                 1260             


Lys Met  Glu Leu Asn Glu Ala  Trp Glu Asp Leu Gln  Gly Arg Thr 
    1265                 1270                 1275             


Lys Asp  Arg Lys Glu Ser Leu  Asn Glu Ala Gln Lys  Phe Tyr Leu 
    1280                 1285                 1290             


Phe Leu  Ser Lys Ala Arg Asp  Leu Gln Asn Trp Ile  Ser Ser Ile 
    1295                 1300                 1305             


Gly Gly  Met Val Ser Ser Gln  Glu Leu Ala Glu Asp  Leu Thr Gly 
    1310                 1315                 1320             


Ile Glu  Ile Leu Leu Glu Arg  His Gln Glu His Arg  Ala Asp Met 
    1325                 1330                 1335             


Glu Ala  Glu Ala Pro Thr Phe  Gln Ala Leu Glu Asp  Phe Ser Ala 
    1340                 1345                 1350             


Glu Leu  Ile Asp Ser Gly His  His Ala Ser Pro Glu  Ile Glu Lys 
    1355                 1360                 1365             


Lys Leu  Gln Ala Val Lys Leu  Glu Arg Asp Asp Leu  Glu Lys Ala 
    1370                 1375                 1380             


Trp Glu  Lys Arg Lys Lys Ile  Leu Asp Gln Cys Leu  Glu Leu Gln 
    1385                 1390                 1395             


Met Phe  Gln Gly Asn Cys Asp  Gln Val Glu Ser Trp  Met Val Ala 
    1400                 1405                 1410             


Arg Glu  Asn Ser Leu Arg Ser  Asp Asp Lys Ser Ser  Leu Asp Ser 
    1415                 1420                 1425             


Leu Glu  Ala Leu Met Lys Lys  Arg Asp Asp Leu Asp  Lys Ala Ile 
    1430                 1435                 1440             


Thr Ala  Gln Glu Gly Lys Ile  Thr Asp Leu Glu His  Phe Ala Glu 
    1445                 1450                 1455             


Ser Leu  Ile Ala Asp Glu His  Tyr Ala Lys Glu Glu  Ile Ala Thr 
    1460                 1465                 1470             


Arg Leu  Gln Arg Val Leu Asp  Arg Trp Lys Ala Leu  Lys Ala Gln 
    1475                 1480                 1485             


Leu Ile  Asp Glu Arg Thr Lys  Leu Gly Asp Tyr Ala  Asn Leu Lys 
    1490                 1495                 1500             


Gln Phe  Tyr Arg Asp Leu Glu  Glu Leu Glu Glu Trp  Ile Ser Glu 
    1505                 1510                 1515             


Met Leu  Pro Thr Ala Cys Asp  Glu Ser Tyr Lys Asp  Ala Thr Asn 
    1520                 1525                 1530             


Ile Gln  Arg Lys Tyr Leu Lys  His Gln Thr Phe Ala  His Glu Val 
    1535                 1540                 1545             


Asp Gly  Arg Ser Glu Gln Val  His Gly Val Ile Asn  Leu Gly Asn 
    1550                 1555                 1560             


Ser Leu  Ile Glu Cys Ser Ala  Cys Asp Gly Asn Glu  Glu Ala Met 
    1565                 1570                 1575             


Lys Glu  Gln Leu Glu Gln Leu  Lys Glu His Trp Asp  His Leu Leu 
    1580                 1585                 1590             


Glu Arg  Thr Asn Asp Lys Gly  Lys Lys Leu Asn Glu  Ala Ser Arg 
    1595                 1600                 1605             


Gln Gln  Arg Phe Asn Thr Ser  Ile Arg Asp Phe Glu  Phe Trp Leu 
    1610                 1615                 1620             


Ser Glu  Ala Glu Thr Leu Leu  Ala Met Lys Asp Gln  Ala Arg Asp 
    1625                 1630                 1635             


Leu Ala  Ser Ala Gly Asn Leu  Leu Lys Lys His Gln  Leu Leu Glu 
    1640                 1645                 1650             


Arg Glu  Met Leu Ala Arg Glu  Asp Ala Leu Lys Asp  Leu Asn Thr 
    1655                 1660                 1665             


Leu Ala  Glu Asp Leu Leu Ser  Ser Gly Thr Phe Asn  Val Asp Gln 
    1670                 1675                 1680             


Ile Val  Lys Lys Lys Asp Asn  Val Asn Lys Arg Phe  Leu Asn Val 
    1685                 1690                 1695             


Gln Glu  Leu Ala Ala Ala His  His Glu Lys Leu Lys  Glu Ala Tyr 
    1700                 1705                 1710             


Ala Leu  Phe Gln Phe Phe Gln  Asp Leu Asp Asp Glu  Glu Ser Trp 
    1715                 1720                 1725             


Ile Glu  Glu Lys Leu Ile Arg  Val Ser Ser Gln Asp  Tyr Gly Arg 
    1730                 1735                 1740             


Asp Leu  Gln Gly Val Gln Asn  Leu Leu Lys Lys His  Lys Arg Leu 
    1745                 1750                 1755             


Glu Gly  Glu Leu Val Ala His  Glu Pro Ala Ile Gln  Asn Val Leu 
    1760                 1765                 1770             


Asp Met  Ala Glu Lys Leu Lys  Asp Lys Ala Ala Val  Gly Gln Glu 
    1775                 1780                 1785             


Glu Ile  Gln Leu Arg Leu Ala  Gln Phe Val Glu His  Trp Glu Lys 
    1790                 1795                 1800             


Leu Lys  Glu Leu Ala Lys Ala  Arg Gly Leu Lys Leu  Glu Glu Ser 
    1805                 1810                 1815             


Leu Glu  Tyr Leu Gln Phe Met  Gln Asn Ala Glu Glu  Glu Glu Ala 
    1820                 1825                 1830             


Trp Ile  Asn Glu Lys Asn Ala  Leu Ala Val Arg Gly  Asp Cys Gly 
    1835                 1840                 1845             


Asp Thr  Leu Ala Ala Thr Gln  Ser Leu Leu Met Lys  His Glu Ala 
    1850                 1855                 1860             


Leu Glu  Asn Asp Phe Ala Val  His Glu Thr Arg Val  Gln Asn Val 
    1865                 1870                 1875             


Cys Ala  Gln Gly Glu Asp Ile  Leu Asn Lys Val Leu  Gln Glu Glu 
    1880                 1885                 1890             


Ser Gln  Asn Lys Glu Ile Ser  Ser Lys Ile Glu Ala  Leu Asn Glu 
    1895                 1900                 1905             


Lys Thr  Pro Ser Leu Ala Lys  Ala Ile Ala Ala Trp  Lys Leu Gln 
    1910                 1915                 1920             


Leu Glu  Asp Asp Tyr Ala Phe  Gln Glu Phe Asn Trp  Lys Ala Asp 
    1925                 1930                 1935             


Val Val  Glu Ala Trp Ile Ala  Asp Lys Glu Thr Ser  Leu Lys Thr 
    1940                 1945                 1950             


Asn Gly  Asn Gly Ala Asp Leu  Gly Asp Phe Leu Thr  Leu Leu Ala 
    1955                 1960                 1965             


Lys Gln  Asp Thr Leu Asp Ala  Ser Leu Gln Ser Phe  Gln Gln Glu 
    1970                 1975                 1980             


Arg Leu  Pro Glu Ile Thr Asp  Leu Lys Asp Lys Leu  Ile Ser Ala 
    1985                 1990                 1995             


Gln His  Asn Gln Ser Lys Ala  Ile Glu Glu Arg Tyr  Ala Ala Leu 
    2000                 2005                 2010             


Leu Lys  Arg Trp Glu Gln Leu  Leu Glu Ala Ser Ala  Val His Arg 
    2015                 2020                 2025             


Gln Lys  Leu Leu Glu Lys Gln  Leu Pro Leu Gln Lys  Ala Glu Asp 
    2030                 2035                 2040             


Leu Phe  Val Glu Phe Ala His  Lys Ala Ser Ala Leu  Asn Asn Trp 
    2045                 2050                 2055             


Cys Glu  Lys Met Glu Glu Asn  Leu Ser Glu Pro Val  His Cys Val 
    2060                 2065                 2070             


Ser Leu  Asn Glu Ile Arg Gln  Leu Gln Lys Asp His  Glu Asp Phe 
    2075                 2080                 2085             


Leu Ala  Ser Leu Ala Arg Ala  Gln Ala Asp Phe Lys  Cys Leu Leu 
    2090                 2095                 2100             


Glu Leu  Asp Gln Gln Ile Lys  Ala Leu Gly Val Pro  Ser Ser Pro 
    2105                 2110                 2115             


Tyr Thr  Trp Leu Thr Val Glu  Val Leu Glu Arg Thr  Trp Lys His 
    2120                 2125                 2130             


Leu Ser  Asp Ile Ile Glu Glu  Arg Glu Gln Glu Leu  Gln Lys Glu 
    2135                 2140                 2145             


Glu Ala  Arg Gln Val Lys Asn  Phe Glu Met Cys Gln  Glu Phe Glu 
    2150                 2155                 2160             


Gln Asn  Ala Ser Thr Phe Leu  Gln Trp Ile Leu Glu  Thr Arg Ala 
    2165                 2170                 2175             


Tyr Phe  Leu Asp Gly Ser Leu  Leu Lys Glu Thr Gly  Thr Leu Glu 
    2180                 2185                 2190             


Ser Gln  Leu Glu Ala Asn Lys  Arg Lys Gln Lys Glu  Ile Gln Ala 
    2195                 2200                 2205             


Met Lys  Arg Gln Leu Thr Lys  Ile Val Asp Leu Gly  Asp Asn Leu 
    2210                 2215                 2220             


Glu Asp  Ala Leu Ile Leu Asp  Ile Lys Tyr Ser Thr  Ile Gly Leu 
    2225                 2230                 2235             


Ala Gln  Gln Trp Asp Gln Leu  Tyr Gln Leu Gly Leu  Arg Met Gln 
    2240                 2245                 2250             


His Asn  Leu Glu Gln Gln Ile  Gln Ala Lys Asp Ile  Lys Gly Val 
    2255                 2260                 2265             


Ser Glu  Glu Thr Leu Lys Glu  Phe Ser Thr Ile Tyr  Lys His Phe 
    2270                 2275                 2280             


Asp Glu  Asn Leu Thr Gly Arg  Leu Thr His Lys Glu  Phe Arg Ser 
    2285                 2290                 2295             


Cys Leu  Arg Gly Leu Asn Tyr  Tyr Leu Pro Met Val  Glu Glu Asp 
    2300                 2305                 2310             


Glu His  Glu Pro Lys Phe Glu  Lys Phe Leu Asp Ala  Val Asp Pro 
    2315                 2320                 2325             


Gly Arg  Lys Gly Tyr Val Ser  Leu Glu Asp Tyr Thr  Ala Phe Leu 
    2330                 2335                 2340             


Ile Asp  Lys Glu Ser Glu Asn  Ile Lys Ser Ser Asp  Glu Ile Glu 
    2345                 2350                 2355             


Asn Ala  Phe Gln Ala Leu Ala  Glu Gly Lys Ser Tyr  Ile Thr Lys 
    2360                 2365                 2370             


Glu Asp  Met Lys Gln Ala Leu  Thr Pro Glu Gln Val  Ser Phe Cys 
    2375                 2380                 2385             


Ala Thr  His Met Gln Gln Tyr  Met Asp Pro Arg Gly  Arg Ser His 
    2390                 2395                 2400             


Leu Ser  Gly Tyr Asp Tyr Val  Gly Phe Thr Asn Ser  Tyr Phe Gly 
    2405                 2410                 2415             


Asn 
    


<210> 69
<211> 2215
<212> DNA
<213> Homo sapiens

<400> 69
aggttttgag acacaggtaa agggagggag acagagagaa atacttgcag agccagcagg       60

tagctgggca gctccttccc ggacggacgg atggacagac gctggggacc ctccactcca      120

tatggaaaga tgacatgacc ttgtggtaga tcccagaact gaggccccag gatgacagaa      180

caggagaccc tggccctact ggaagtgaag aggtctgatt ccccagagaa gagctcaccc      240

caggccttgg ttcccaatgg ccggcagcca gaaggggaag gtggggccga atccccggga      300

gctgagtccc tcagagtggg gtcttcagct ggatctccca cagccataga gggggctgag      360

gatggtctag acagcacagt aagtgaggct gccaccttgc cctgggggac tggccctcag      420

cccagtgctc cgttcccgga tccccctggc tggcgggaca ttgaaccaga gccccctgag      480

tcagaaccac ttaccaagct agaggagctg cccgaagacg atgccaacct gctgcctgag      540

aaagcggccc gtgccttcgt gcctattgac ctacagtgca ttgagcggca gccccaagaa      600

gaccttatcg tgcgctgtga ggcaggcgag ggcgagtgcc gaaccttcat gcccccccgg      660

gtcacccacc ccgaccccac tgagcgcaag tgggctgagg cagtggtgag gccgcctggc      720

tgttcctgtg ggggctgcgg gagctgtgga gaccgtgagt ggctaagggc tgtggcctcc      780

gtgggagccg cactcattct cttcccttgc ctactatacg gggcatatgc cttcctgccg      840

tttgatgtcc cacggctgcc caccatgagt tcccgcctga tctacacact gcgctgcggg      900

gtctttgcca ccttccccat tgtgctgggg atcctggtgt acgggctgag cctgttatgc      960

ttttctgccc ttcggccctt tggggagcca cggcgggagg tggagatcca ccggcgatat     1020

gtggcccagt cggtccagct ctttattctc tacttcttca acctggccgt gctttccact     1080

tacctgcccc aggataccct caaactgctc cctctgctca ctggtctctt tgccgtctcc     1140

cggctgatct actggctgac ctttgccgtg ggccgctcct tccgaggctt cggctacggc     1200

ctgacgtttc tgccactgct gtcgatgctg atgtggaacc tctactacat gttcgtggtg     1260

gagccggagc gcatgctcac tgccaccgag agccgcctgg actacccgga ccacgcccgc     1320

tcggcctccg actacaggcc ccgcccctgg ggctgagcct ctccgccctc gccctcggag     1380

tagggggtag cggcttgggt ctgacacatc tttgaacctt gtggccaggc ctggacttcg     1440

cccccaggcc taggaccgcg gtgggtggaa ccctgctact gccccaacag ggactccaat     1500

caatcggagt tctccccttg ccggagctgc ccttcacctt tggggcccga gacagtcata     1560

agggatggac ttagttttct tgcagggaaa aaggtggaca gccgtgtttc ttaaggatgc     1620

tgagggcatg gggccaggac caggggagag gcacagctcc ttcctgagca gcctctcacc     1680

actgccacaa ggctccctaa tgctggtctc tgctccactc cccggcttcc cgtgaggcag     1740

gaggcagagc cacagccaag gccctgacca cttctgtgcc agttgtctaa gcagagcgcc     1800

tcagggacgc tggaaatgcc ttaaggatag aggctgggca tcacatcaaa tgggactgtg     1860

gtgtttggtg aaaaccttcc tgaggatctg gattcaggac cctccatgac tggcctattt     1920

actgtttaca gctggccagt gcagagctgc tgctctttta cctttttagg cccctgtaac     1980

ttcccacctt taaactgccc agaaggcatg cctctcccac aggaagaggg gagcagacag     2040

ggaaatctgc ctaccaagag gggtgtgtgt gtctttgtgc ccacacgtgg tggctgggga     2100

gtgcctggat ggtgcggtgg ttgatgttaa cctagtgtgt gtgtgtgtgt gtgtgtgtgt     2160

gtgtgtgtgt gtgtgtgtgt aacaataaat tactaccagt caaaaaaaaa aaaaa          2215


<210> 70
<211> 394
<212> PRT
<213> Homo sapiens

<400> 70
Met Thr Glu Gln Glu Thr Leu Ala Leu Leu Glu Val Lys Arg Ser Asp 
1               5                   10                  15      


Ser Pro Glu Lys Ser Ser Pro Gln Ala Leu Val Pro Asn Gly Arg Gln 
            20                  25                  30          


Pro Glu Gly Glu Gly Gly Ala Glu Ser Pro Gly Ala Glu Ser Leu Arg 
        35                  40                  45              


Val Gly Ser Ser Ala Gly Ser Pro Thr Ala Ile Glu Gly Ala Glu Asp 
    50                  55                  60                  


Gly Leu Asp Ser Thr Val Ser Glu Ala Ala Thr Leu Pro Trp Gly Thr 
65                  70                  75                  80  


Gly Pro Gln Pro Ser Ala Pro Phe Pro Asp Pro Pro Gly Trp Arg Asp 
                85                  90                  95      


Ile Glu Pro Glu Pro Pro Glu Ser Glu Pro Leu Thr Lys Leu Glu Glu 
            100                 105                 110         


Leu Pro Glu Asp Asp Ala Asn Leu Leu Pro Glu Lys Ala Ala Arg Ala 
        115                 120                 125             


Phe Val Pro Ile Asp Leu Gln Cys Ile Glu Arg Gln Pro Gln Glu Asp 
    130                 135                 140                 


Leu Ile Val Arg Cys Glu Ala Gly Glu Gly Glu Cys Arg Thr Phe Met 
145                 150                 155                 160 


Pro Pro Arg Val Thr His Pro Asp Pro Thr Glu Arg Lys Trp Ala Glu 
                165                 170                 175     


Ala Val Val Arg Pro Pro Gly Cys Ser Cys Gly Gly Cys Gly Ser Cys 
            180                 185                 190         


Gly Asp Arg Glu Trp Leu Arg Ala Val Ala Ser Val Gly Ala Ala Leu 
        195                 200                 205             


Ile Leu Phe Pro Cys Leu Leu Tyr Gly Ala Tyr Ala Phe Leu Pro Phe 
    210                 215                 220                 


Asp Val Pro Arg Leu Pro Thr Met Ser Ser Arg Leu Ile Tyr Thr Leu 
225                 230                 235                 240 


Arg Cys Gly Val Phe Ala Thr Phe Pro Ile Val Leu Gly Ile Leu Val 
                245                 250                 255     


Tyr Gly Leu Ser Leu Leu Cys Phe Ser Ala Leu Arg Pro Phe Gly Glu 
            260                 265                 270         


Pro Arg Arg Glu Val Glu Ile His Arg Arg Tyr Val Ala Gln Ser Val 
        275                 280                 285             


Gln Leu Phe Ile Leu Tyr Phe Phe Asn Leu Ala Val Leu Ser Thr Tyr 
    290                 295                 300                 


Leu Pro Gln Asp Thr Leu Lys Leu Leu Pro Leu Leu Thr Gly Leu Phe 
305                 310                 315                 320 


Ala Val Ser Arg Leu Ile Tyr Trp Leu Thr Phe Ala Val Gly Arg Ser 
                325                 330                 335     


Phe Arg Gly Phe Gly Tyr Gly Leu Thr Phe Leu Pro Leu Leu Ser Met 
            340                 345                 350         


Leu Met Trp Asn Leu Tyr Tyr Met Phe Val Val Glu Pro Glu Arg Met 
        355                 360                 365             


Leu Thr Ala Thr Glu Ser Arg Leu Asp Tyr Pro Asp His Ala Arg Ser 
    370                 375                 380                 


Ala Ser Asp Tyr Arg Pro Arg Pro Trp Gly 
385                 390                 


<210> 71
<211> 1282
<212> DNA
<213> Homo sapiens

<400> 71
ggaagtctgt caactgggag ggggagaggg gggtgatggg ccaggaatgg ggtccccggg       60

catggtgctg ggcctcctgg tgcagatctg ggccctgcaa gaagcctcaa gcctgagcgt      120

gcagcagggg cccaacttgc tgcaggtgag gcagggcagt caggcgaccc tggtctgcca      180

ggtggaccag gccacagcct gggaacggct ccgtgttaag tggacaaagg atggggccat      240

cctgtgtcaa ccgtacatca ccaacggcag cctcagcctg ggggtctgcg ggccccaggg      300

acggctctcc tggcaggcac ccagccatct caccctgcag ctggaccctg tgagcctcaa      360

ccacagcggg gcgtacgtgt gctgggcggc cgtagagatt cctgagttgg aggaggctga      420

gggcaacata acaaggctct ttgtggaccc agatgacccc acacagaaca gaaaccggat      480

cgcaagcttc ccaggattcc tcttcgtgct gctgggggtg ggaagcatgg gtgtggctgc      540

gatcgtgtgg ggtgcctggt tctggggccg ccgcagctgc cagcaaaggg actcaggtaa      600

cagcccagga aatgcattct acagcaacgt cctataccgg ccccgggggg ccccaaagaa      660

gagtgaggac tgctctggag aggggaagga ccagaggggc cagagcattt attcaacctc      720

cttcccgcaa ccggcccccc gccagccgca cctggcgtca agaccctgcc ccagcccgag      780

accctgcccc agccccaggc ccggccaccc cgtctctatg gtcagggtct ctcctagacc      840

aagccccacc cagcagccga ggccaaaagg gttccccaaa gtgggagagg agtgagagat      900

cccaggagac ctcaacagga ccccacccat aggtacacac aaaaaagggg ggatcgaggc      960

cagacacggt ggctcacgcc tgtaatccca gcagtttggg aagccgaggc gggtggaaca     1020

cttgaggtca ggggtttgag accagcctgg cttgaacctg ggaggcggag gttgcagtga     1080

gccgagattg cgccactgca ctccagcctg ggcgacagag tgagactccg tctcaaaaaa     1140

aacaaaaagc aggaggattg ggagcctgtc agccccatcc tgagaccccg tcctcatttc     1200

tgtaatgatg gatctcgctc ccactttccc ccaagaacct aataaaggct tgtgaagaaa     1260

aagcaaaaaa aaaaaaaaaa aa                                              1282


<210> 72
<211> 282
<212> PRT
<213> Homo sapiens

<400> 72
Met Gly Ser Pro Gly Met Val Leu Gly Leu Leu Val Gln Ile Trp Ala 
1               5                   10                  15      


Leu Gln Glu Ala Ser Ser Leu Ser Val Gln Gln Gly Pro Asn Leu Leu 
            20                  25                  30          


Gln Val Arg Gln Gly Ser Gln Ala Thr Leu Val Cys Gln Val Asp Gln 
        35                  40                  45              


Ala Thr Ala Trp Glu Arg Leu Arg Val Lys Trp Thr Lys Asp Gly Ala 
    50                  55                  60                  


Ile Leu Cys Gln Pro Tyr Ile Thr Asn Gly Ser Leu Ser Leu Gly Val 
65                  70                  75                  80  


Cys Gly Pro Gln Gly Arg Leu Ser Trp Gln Ala Pro Ser His Leu Thr 
                85                  90                  95      


Leu Gln Leu Asp Pro Val Ser Leu Asn His Ser Gly Ala Tyr Val Cys 
            100                 105                 110         


Trp Ala Ala Val Glu Ile Pro Glu Leu Glu Glu Ala Glu Gly Asn Ile 
        115                 120                 125             


Thr Arg Leu Phe Val Asp Pro Asp Asp Pro Thr Gln Asn Arg Asn Arg 
    130                 135                 140                 


Ile Ala Ser Phe Pro Gly Phe Leu Phe Val Leu Leu Gly Val Gly Ser 
145                 150                 155                 160 


Met Gly Val Ala Ala Ile Val Trp Gly Ala Trp Phe Trp Gly Arg Arg 
                165                 170                 175     


Ser Cys Gln Gln Arg Asp Ser Gly Asn Ser Pro Gly Asn Ala Phe Tyr 
            180                 185                 190         


Ser Asn Val Leu Tyr Arg Pro Arg Gly Ala Pro Lys Lys Ser Glu Asp 
        195                 200                 205             


Cys Ser Gly Glu Gly Lys Asp Gln Arg Gly Gln Ser Ile Tyr Ser Thr 
    210                 215                 220                 


Ser Phe Pro Gln Pro Ala Pro Arg Gln Pro His Leu Ala Ser Arg Pro 
225                 230                 235                 240 


Cys Pro Ser Pro Arg Pro Cys Pro Ser Pro Arg Pro Gly His Pro Val 
                245                 250                 255     


Ser Met Val Arg Val Ser Pro Arg Pro Ser Pro Thr Gln Gln Pro Arg 
            260                 265                 270         


Pro Lys Gly Phe Pro Lys Val Gly Glu Glu 
        275                 280         


<210> 73
<211> 1843
<212> DNA
<213> Homo sapiens

<400> 73
gggcacgagg gcagagccag ttcctagcgc agagccgcgc ccgccatgag ggagatcgtg       60

cacatccagg cgggccagtg cgggaaccag atcggcacca agttttggga agtgatcagc      120

gatgagcacg gcatcgaccc ggccggaggc tacgtgggag actcggcgct gcagctggag      180

agaatcaacg tctactacaa tgagtcatcg tctcagaaat atgtgcccag ggccgccctg      240

gtggacttag agccaggcac catggacagc gtgcggtctg ggccttttgg gcagcttttc      300

cggcctgaca acttcatctt tggccagacg ggtgcaggga acaactgggc gaaagggcac      360

tacacggagg gcgcggagct ggtggacgca gtgctggacg tggtgcggaa ggagtgcgag      420

cactgcgact gcctgcaggg cttccagctc acgcactcgc tgggcggcgg cacgggctca      480

ggcatgggca cgctgctcat cagcaagatc cgtgaggagt tcccggaccg catcatgaac      540

accttcagcg tcatgccctc gcccaaggtg tcggacacgg tggtggagcc ctacaatgcc      600

acactgtcgg tgcaccagct ggtggagaat acagacgaga cctactgcat cgacaacgag      660

gcgctctatg acatctgctt ccgcactctg aagctgacaa cgcccaccta cggggacctc      720

aaccacctgg tgtccgccac catgagtggg gtcaccacct cgctgcgctt cccgggccag      780

ctcaatgctg acctgcgcaa gctggcggtg aacatggtgc ccttcccgcg cctgcacttc      840

ttcatgcctg gcttcgcgcc gctcaccagc cgcggcagcc agcagtaccg ggccctgacc      900

gtgcccgagc tcacccagca gatgttcgac gccaggaaca tgatggccgc ctgcgatccg      960

cgccatggcc gctacctgac cgtggccacc gtgttccgcg ggcccatgtc catgaaggag     1020

gtggacgagc agatgctggc catccagagt aagaacagca gctacttcgt ggagtggatt     1080

cccaacaacg tgaaggtggc cgtgtgcgac atcccgcccc gcggcctgaa gatggcctcc     1140

accttcatcg gcaacagcac ggccatccag gagctgttca agcgcatctc cgagcagttc     1200

tcagccatgt tccggcgcaa ggccttcctg cactggttca cgggtgaggg catggatgaa     1260

atggagttca ccgaggcgga gagcaacatg aacgacctgg tatccgagta ccagcagtac     1320

caggatgcca ccgccaatga cggggaggaa gcttttgagg atgaggaaga ggagatcgat     1380

ggatagtcgg aatagagccg ccccaactca gatcctacaa cacgcaagtt ccttcttgaa     1440

ccctggtgcc tcctacccta tggccctgaa tggtgcactg gtttaattgt gttggtgtcg     1500

gcccctcaca aatgcagcca agtcatgtaa ttagtcatct ggaacaaaga ctaaaaacag     1560

cagagaattg cgggttctac ccagtcagaa gatcacacca tggagacttt ctactagagg     1620

acttgaaaga gaactgaggg gccacaaaat aaacttcacc ttccattaag tgttcaagca     1680

tgtctgcaaa ttaggaggga gttagaaaca gtctttttca tcctttgtga tgaagcctga     1740

aattgtgccg tgttgcctta tatgaatatg cagtatggga ctttgaaata atgattcata     1800

ataaaatact aaacgtgtgt cttcaaaaaa aaaaaaaaaa aaa                       1843


<210> 74
<211> 446
<212> PRT
<213> Homo sapiens

<400> 74
Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Thr Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Ala Gly Gly Tyr Val Gly Asp Ser Ala Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ser Ser Ser Gln Lys Tyr Val Pro Arg Ala Ala 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Leu Phe Arg Pro Asp Asn Phe Ile Phe Gly Gln Thr Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ala Val Leu Asp Val Val Arg Lys Glu Cys Glu His Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Phe Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Met Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Ser Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Arg Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Thr Val Phe Arg Gly Pro 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ala Ile Gln Ser Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Val Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Ser Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Ser Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Phe Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Asn Asp 
            420                 425                 430         


Gly Glu Glu Ala Phe Glu Asp Glu Glu Glu Glu Ile Asp Gly 
        435                 440                 445     


<210> 75
<211> 605
<212> DNA
<213> Homo sapiens

<400> 75
agacttcctc cttcacttgc ctggacgctg cgccacatcc caccggccct tacactgtgg       60

tgtccagcag catccggctt catgggggga cttgaaccct gcagcaggct cctgctcctg      120

cctctcctgc tggctgtaag tggtctccgt cctgtccagg cccaggccca gagcgattgc      180

agttgctcta cggtgagccc gggcgtgctg gcagggatcg tgatgggaga cctggtgctg      240

acagtgctca ttgccctggc cgtgtacttc ctgggccggc tggtccctcg ggggcgaggg      300

gctgcggagg cgacccggaa acagcgtatc actgagaccg agtcgcctta tcaggagctc      360

cagggtcaga ggtcggatgt ctacagcgac ctcaacacac agaggccgta ttacaaatga      420

gcccgaatca tgacagtcag caacatgata cctggatcca gccattcctg aagcccaccc      480

tgcacctcat tccaactcct accgcgatac agacccacag agtgccatcc ctgagagacc      540

agaccgctcc ccaatactct cctaaaataa acatgaagca caaaaacaaa aaaaaaaaaa      600

aaaaa                                                                  605


<210> 76
<211> 112
<212> PRT
<213> Homo sapiens

<400> 76
Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Thr Arg Lys 
65                  70                  75                  80  


Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln 
                85                  90                  95      


Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
            100                 105                 110         


<210> 77
<211> 3277
<212> DNA
<213> Homo sapiens

<400> 77
gcgtgcacgc tgacgccgcg cagtctcgtc ccctgccgcc gccgtcgccg ctgctgtcgc       60

cgccgccgcc gccattggag tcgacgcctc ctcagtgcgt ccgcgtcccg ggctcaccgc      120

cgctgccgcc tcgccagggg cccgcgcgcc cagcagccgc cgccgccgcc cggccggcgc      180

ccggggaatt ggcggcgggg cccggggccg cgcgagctag ggtgacaggc ccggcctcta      240

ggggaggccc gagccggcgg gcgccccggc cccgcgtcta gttgttcatg aagcatgtcg      300

gccaccagcg tggacaccca gagaacaaaa ggacaagata ataaagtaca aaatggttcg      360

ttacatcaga aggatacagt tcatgacaat gactttgagc cctaccttac tggacagtca      420

aatcagagta acagttaccc ctcaatgagc gacccctacc tgtccagcta ttacccgccg      480

tccattggat ttccttactc cctcaatgag gctccgtggt ctactgcagg ggaccctccg      540

attccatacc tcaccaccta cggacagctc agtaacggag accatcattt tatgcacgat      600

gctgtttttg ggcagcctgg gggcctgggg aacaacatct atcagcacag gttcaatttt      660

ttccctgaaa accctgcgtt ctcagcatgg gggacaagtg ggtctcaagg tcagcagacc      720

cagagctccg cgtatgggag cagctacacc taccccccga gctccctggg tggcacggtg      780

gttgatgggc agccaggctt tcacagcgac accctcagca aggcccccgg gatgaacagc      840

ctggagcagg gcatggttgg cctgaagatt ggggacgtca gctcctccgc cgtcaagacg      900

gtgggctctg tcgtcagcag cgtggcactg actggtgtcc tttctggcaa cggtgggaca      960

aatgtgaaca tgccagtttc aaagccgacc tcgtgggctg ccattgccag caagcctgca     1020

aaaccacagc ctaaaatgaa aacaaagagc gggcctgtca tggggggtgg gctgccccct     1080

ccacccataa agcataacat ggacattggc acctgggata acaaggggcc tgtgccgaag     1140

gccccagtcc cccagcaggc accctctcca caggctgccc cacagcccca gcaggtggct     1200

cagcctctcc cagcacagcc cccagctttg gctcaaccgc agtatcagag ccctcagcag     1260

ccaccccaga cccgctgggt tgccccacgc aacagaaacg cggcgtttgg gcagagcgga     1320

ggggctggca gcgatagcaa ctctcctgga aacgtccagc ctaattctgc ccccagcgtc     1380

gaatcccacc ccgtccttga aaaactgaag gctgctcaca gctacaaccc gaaagagttt     1440

gagtggaatc tgaaaagcgg gcgtgtgttc atcatcaaga gctactctga ggacgacatc     1500

caccgctcca ttaagtactc catctggtgt agcacagagc acggcaacaa gcgcctggac     1560

agcgccttcc gctgcatgag cagcaagggg cccgtctacc tgctcttcag cgtcaatggg     1620

agtgggcatt tttgtggggt ggccgagatg aagtcccccg tggactacgg caccagtgcc     1680

ggggtctggt ctcaggacaa gtggaagggg aagtttgatg tccagtggat ttttgttaag     1740

gatgtaccca ataaccagct ccggcacatc aggctggaga ataacgacaa caaaccggtc     1800

acaaactccc gggacaccca ggaggtgccc ttagaaaaag ccaagcaagt gctgaaaatt     1860

atcagttcct acaagcacac aacctccatc ttcgacgact ttgctcacta cgagaagcgc     1920

caggaggagg aggaggtggt gcgcaaggaa cggcagagtc gaaacaaaca atgagggcga     1980

accagtttct tacatgttct aacgtttgac tttgaaaaca gtttaaaaca cgtgtgcttg     2040

gtcagctcca gtgtgtcgtc ccgtgcgggg gttgagtgtt gcatctttgc ctttcttgtc     2100

gttgattttt gcccagatgg atctgcattt atttgtactt tttctatgta ttataatcct     2160

gtagaagtca ctaataaagg agtatttttt ttgtcagctt atcaatcaga ctgatctaat     2220

gtgaaatgta agtatcctta aaaacaaagc atctattttg gcagaaattg tgttcttaaa     2280

ttcagtcatt tgatattctg tgagacttca tatttctcat ccctttattg ctttttagca     2340

aacataagaa accatgagtc attttgtcat ttagagtatt ctgataaaat ctcttgaaaa     2400

tactgaaatc aaaaggttaa tgattttttg ttcattctga tttgtcattt tattatctgt     2460

tatcggtcta aagtgctaat ttacccattt gatttttctg ctagacagat aacttttaat     2520

ttttcaaatt tggcagacac tttttttttt tttttgaaaa tctttccttc cagatctgtt     2580

gcccactgaa cagccacccg tccctcactg tcctggtgtc cgattgggct ggatggtgtt     2640

ggggcatgat gtgtggagga actggaaggt gctttaggtc tggttcaggg tcgggcattc     2700

tttgttgttt gcacatcttt ttaaatttta caccttttct taagaattct aatgccgtct     2760

taagttttta taccaataat gctgagcttt aagtgtagga tctggtagta cagacagtgt     2820

gatggatgat gctgctggtt gtaaatttca tcgtgtgtgt ctaatttttt ttcctgttga     2880

atgggtaaaa acaaaacaaa acttttttta gaagatgaat ttgctgtcat gttttgtgga     2940

atgagggacc gttgagctca ctaccacctg gagtttgagt tgaagcatga aaatggtgcc     3000

catgcctgac gctccagcgc ctggatctgc acgtgccctt gtagaggatc cttaccgtcc     3060

tagagagcag acgctttctg aaaactactt gctccaaaag accctctgag ttaacgtttc     3120

agctgtatca ttagacttgt atttagagcg tgtcacttcc tctgaactgt tactgcctga     3180

atggagtcct ggacgacatt gggtttttcc tctaggagaa tacaagcctt aataaacaat     3240

actatttagc aaaaaaaaaa aaaaaaaaaa aaaaaaa                              3277


<210> 78
<211> 559
<212> PRT
<213> Homo sapiens

<400> 78
Met Ser Ala Thr Ser Val Asp Thr Gln Arg Thr Lys Gly Gln Asp Asn 
1               5                   10                  15      


Lys Val Gln Asn Gly Ser Leu His Gln Lys Asp Thr Val His Asp Asn 
            20                  25                  30          


Asp Phe Glu Pro Tyr Leu Thr Gly Gln Ser Asn Gln Ser Asn Ser Tyr 
        35                  40                  45              


Pro Ser Met Ser Asp Pro Tyr Leu Ser Ser Tyr Tyr Pro Pro Ser Ile 
    50                  55                  60                  


Gly Phe Pro Tyr Ser Leu Asn Glu Ala Pro Trp Ser Thr Ala Gly Asp 
65                  70                  75                  80  


Pro Pro Ile Pro Tyr Leu Thr Thr Tyr Gly Gln Leu Ser Asn Gly Asp 
                85                  90                  95      


His His Phe Met His Asp Ala Val Phe Gly Gln Pro Gly Gly Leu Gly 
            100                 105                 110         


Asn Asn Ile Tyr Gln His Arg Phe Asn Phe Phe Pro Glu Asn Pro Ala 
        115                 120                 125             


Phe Ser Ala Trp Gly Thr Ser Gly Ser Gln Gly Gln Gln Thr Gln Ser 
    130                 135                 140                 


Ser Ala Tyr Gly Ser Ser Tyr Thr Tyr Pro Pro Ser Ser Leu Gly Gly 
145                 150                 155                 160 


Thr Val Val Asp Gly Gln Pro Gly Phe His Ser Asp Thr Leu Ser Lys 
                165                 170                 175     


Ala Pro Gly Met Asn Ser Leu Glu Gln Gly Met Val Gly Leu Lys Ile 
            180                 185                 190         


Gly Asp Val Ser Ser Ser Ala Val Lys Thr Val Gly Ser Val Val Ser 
        195                 200                 205             


Ser Val Ala Leu Thr Gly Val Leu Ser Gly Asn Gly Gly Thr Asn Val 
    210                 215                 220                 


Asn Met Pro Val Ser Lys Pro Thr Ser Trp Ala Ala Ile Ala Ser Lys 
225                 230                 235                 240 


Pro Ala Lys Pro Gln Pro Lys Met Lys Thr Lys Ser Gly Pro Val Met 
                245                 250                 255     


Gly Gly Gly Leu Pro Pro Pro Pro Ile Lys His Asn Met Asp Ile Gly 
            260                 265                 270         


Thr Trp Asp Asn Lys Gly Pro Val Pro Lys Ala Pro Val Pro Gln Gln 
        275                 280                 285             


Ala Pro Ser Pro Gln Ala Ala Pro Gln Pro Gln Gln Val Ala Gln Pro 
    290                 295                 300                 


Leu Pro Ala Gln Pro Pro Ala Leu Ala Gln Pro Gln Tyr Gln Ser Pro 
305                 310                 315                 320 


Gln Gln Pro Pro Gln Thr Arg Trp Val Ala Pro Arg Asn Arg Asn Ala 
                325                 330                 335     


Ala Phe Gly Gln Ser Gly Gly Ala Gly Ser Asp Ser Asn Ser Pro Gly 
            340                 345                 350         


Asn Val Gln Pro Asn Ser Ala Pro Ser Val Glu Ser His Pro Val Leu 
        355                 360                 365             


Glu Lys Leu Lys Ala Ala His Ser Tyr Asn Pro Lys Glu Phe Glu Trp 
    370                 375                 380                 


Asn Leu Lys Ser Gly Arg Val Phe Ile Ile Lys Ser Tyr Ser Glu Asp 
385                 390                 395                 400 


Asp Ile His Arg Ser Ile Lys Tyr Ser Ile Trp Cys Ser Thr Glu His 
                405                 410                 415     


Gly Asn Lys Arg Leu Asp Ser Ala Phe Arg Cys Met Ser Ser Lys Gly 
            420                 425                 430         


Pro Val Tyr Leu Leu Phe Ser Val Asn Gly Ser Gly His Phe Cys Gly 
        435                 440                 445             


Val Ala Glu Met Lys Ser Pro Val Asp Tyr Gly Thr Ser Ala Gly Val 
    450                 455                 460                 


Trp Ser Gln Asp Lys Trp Lys Gly Lys Phe Asp Val Gln Trp Ile Phe 
465                 470                 475                 480 


Val Lys Asp Val Pro Asn Asn Gln Leu Arg His Ile Arg Leu Glu Asn 
                485                 490                 495     


Asn Asp Asn Lys Pro Val Thr Asn Ser Arg Asp Thr Gln Glu Val Pro 
            500                 505                 510         


Leu Glu Lys Ala Lys Gln Val Leu Lys Ile Ile Ser Ser Tyr Lys His 
        515                 520                 525             


Thr Thr Ser Ile Phe Asp Asp Phe Ala His Tyr Glu Lys Arg Gln Glu 
    530                 535                 540                 


Glu Glu Glu Val Val Arg Lys Glu Arg Gln Ser Arg Asn Lys Gln 
545                 550                 555                 


<210> 79
<211> 4607
<212> DNA
<213> Homo sapiens

<400> 79
gcggccgcaa gcacgggggc gaatccccgc tgggtcgagg gcctgaacgg gagccaatcg       60

agcagccgag gctactgcca atcacgcggc tccctccaat cccacccgtg ccatttccaa      120

aatctcggtc ccactgtgca gctcaaatgt ggtgttcact ctgccaatcg ctggaggata      180

gagtgggaac aggaataagc agagttaaga ggccaggaca aaagaagtta aagagcgccc      240

aatacataca tgtttttgaa ggcgggcaga gggaataaag tccccccagt gagggtctat      300

gggcctgatt gtgtagttct gatggagccc cctttgagca agaggaaccc gccagcgctg      360

agattagcgg atttggcaac ggctcaggtc cagccgcttc agaatatgac aggcttcccg      420

gcgctggccg gcccgcccgc ccactcccaa ctccgggccg ccgtcgcgca cctccgcctg      480

cgggacctgg gcgctgaccc cggcgtggcc accactccgc tcggacccga gcacatggcc      540

caggcgagca cgctgggcct cagccctccc tcccaggcgt tcccggcaca cccggaggct      600

ccggcagccg ccgcccgtgc tgcagccttg gtcgcgcacc ccggcgcggg cagctacccc      660

tgcggcgggg gcagcagtgg cgcgcagccc tccgcgcccc cgcccccagc ccctcctctt      720

cctcccaccc cttcaccccc tccccctccc ccgcctcctc ctcctcctgc cctctcgggc      780

tacaccacca ccaacagtgg cggcggcggc agcagcggca aaggccacag cagggacttc      840

gtcctccgga gggacctttc cgccacggcc cccgcggcgg ccatgcacgg ggccccgctc      900

ggaggggagc agcggtccgg caccggctcc ccccagcacc cggccccgcc tccccactcg      960

gccggcatgt tcatctccgc cagcggcacc tacgcgggcc cggacggcag cggcggcccg     1020

gcgctcttcc ccgcgctgca cgacacgccg ggggccccag gcggccaccc gcacccgctc     1080

aacggccaga tgcgcctggg gctggcggcg gcagcggcag ccgcggcggc tgagctgtac     1140

ggccgcgccg aaccgccctt cgcgccgcgc tctggggacg cgcactacgg ggcggttgcg     1200

gccgcagcgg cggccgccct gcacggctac ggagccgtga acttaaacct gaacctggcg     1260

gctgcggcgg ccgcagcagc ggccgggccc gggccccacc tgcagcacca cgcgccgccc     1320

ccggcgccgc cgccgccgcc ggcgcccgcg cagcacccgc accagcacca cccccacctc     1380

ccaggggcgg ctggggcctt cctgcgctac atgcggcagc caatcaagca ggagctcatc     1440

tgcaagtgga tcgaccccga cgagctggcc gggctgccgc cgccgccgcc gccgccgccg     1500

ccgccgccgc caccgccccc ggccggcggc gccaagccct gctccaaaac tttcggcacc     1560

atgcacgagc tggtgaatca cgtcacggtg gagcacgtgg gaggccccga gcagagcagc     1620

cacgtctgct tctgggagga ctgtccgcgc gagggcaagc ccttcaaggc caaatacaag     1680

ctcatcaacc acatccgcgt gcacaccggc gagaagccct ttccctgccc tttccccggc     1740

tgcggcaagg tcttcgcgcg ctccgagaac ctcaagatcc acaagcgtac tcatacaggg     1800

gaaaagcctt tcaaatgtga atttgatggc tgtgacagga agtttgccaa tagcagtgat     1860

cggaagaaac attcccatgt ccacaccagt gacaagccct actactgcaa gattcgaggc     1920

tgtgacaaat cctacactca cccaagctcc ctgaggaagc acatgaagat tcactgcaag     1980

tccccgccac cttctccagg accccttggt tactcatcag tggggactcc agtgggcgcc     2040

cccttgtccc ctgtgctgga cccagccagg agtcactcca gcactctgtc ccctcaggtg     2100

accaacctca atgagtggta cgtttgccag gccagtgggg cccccagcca cctccacacc     2160

ccttccagca acggaaccac ctctgagact gaagatgagg aaatttacgg gaaccctgaa     2220

gttgtgcgga cgatacatta gaatttatta ttaataataa taagtgaaat aataagtggg     2280

agtccttgga ccacatccta acctgagaca atgccgagcc tgagacaaac ccgtgactca     2340

gacttgccac cgggtctaat tagccctatt tattcagtat gaaaccctat ggtgtttgta     2400

catttaatta atttaattaa gatatttggg cttttttttt tttttttctt aaaaaacaaa     2460

caaaaaacaa ccaagctgga cttgtacatt gcaggaggat ggggctgggg gcaaattgta     2520

ccaaggaaaa tgaatggaga gattagttaa tggcgataca cactgccgat gcaatatata     2580

tatatatata tatatacata tatatatata ttattttttt taaaaggggg agaaaaagag     2640

cattaagtca gaacttaaca cagcaccaag gccctctgca tttcccagag tgcctctcaa     2700

atgcctttga caccatacca tgggctgctt ttgagcctcc ttgttggacc ctaattctgc     2760

caaggcctct tgattgtaaa ccacacacct gctgcattgc caacagatcc tgttccgtac     2820

ctgtgtccaa aaacatttgt aaaaaccctt tgagtttaat atttgtaatt tttaatttcc     2880

actcttttat tactgatctt agcttaatac aatattttta tacaggatta tttcttcagt     2940

atcctactgt gtgattttaa aaaaagatgc agcaacctta atatatctcc atatcttgtg     3000

ctactgtgat tgttcaagca aaagtggaga gaagaaaagc tgctgcaaaa gacaactgtg     3060

aaactgtgat attttataaa atagaagaaa ttcaagtgct ttctttttcc tatatgtttt     3120

ttttttttta tctgaattct cagatactgc ctcctaactg tgtccaaact tcttgtgtaa     3180

taaagagatt ctgttttcga tcctaagttc tttgggatgc caacattcac agtcaagtct     3240

tgaggaggtg tgatgatggc atcatgccta tttttttgga aagctgttgt ttttaaaaca     3300

ggccaacacc tcttttatac tgttgtatca gccttttaaa aagtctattt ttcaatgcct     3360

gaaactgcat tttaatgcat tttcttccac ctgagcactg agcacaccaa actggaatcc     3420

atttgaaaat gacagtgtgt gaagtgtatg atttacatta aaagagggga gggagttgcc     3480

atacatatta aaaattttta aaaggtttat agttaccacc aaacactgat gaatgtgtga     3540

cctttgccag agctgtcaag ctaggataaa aaaggtcaag gacctaggac aataactctt     3600

agtcgattta ttttcggttg gtacaacaca tctcctgtgc aaaatgtagt ccatcagaaa     3660

catcctacag atacactaaa gagcactaat ttatccttag agaccccgaa gacaccccct     3720

ccccagggtt tgtagaaatt tgttttgtgt gctgtgagtg gttgatgtag tcttgtcatt     3780

gttaataact tgtatgtgaa cactattatt tgtacagttg aattaattta ttttcagaca     3840

tcatcctttt tttttttctt tcctggaaga gttcaaagca caccaaagaa ttatattata     3900

cattttggtg aaagattgtc atttatgatc catggtttat ttaaaaaaaa aaggaaagaa     3960

aatggaaaaa tatattttta agcttacttg aatgaacaac gtaatgtgaa aaccaagact     4020

cttcctgcat gtcttttttg cattgtgttg ataagattat atatagttta tagatatatt     4080

atattactag tacagtgcat ggtgctgtca cttggaaagc ctttcaatgt tgtcttcaga     4140

ttgttgtgat gaatatgaaa catgcagacc ctcctttata aagaaaaaga ccttaaaact     4200

tgaatatgag ataattttac attttaaaag tttatttgat tttcatatta ttcactttca     4260

aagccctttc aaatagaaaa ggtatgaact tttgggggga taatttatgt atcgtaaact     4320

tattagaaca aaatattcct gatgtataat gagttgtttt atttatacaa ctttttcaat     4380

ggtagtttgc actattcttt attatgctac aggtttattt attatgaaac aaaggaatat     4440

gtattttatg tattttacca tgcataggtt aactctttgc cacagattta ttggttcttg     4500

atacacctaa aataaaaaaa aatgtgtacc tccaatagag agcaagcaag aatgattatg     4560

aagtaacaaa tttaataaag gtattcttgt tattattaaa aaaaaaa                   4607


<210> 80
<211> 663
<212> PRT
<213> Homo sapiens

<400> 80
Met Phe Leu Lys Ala Gly Arg Gly Asn Lys Val Pro Pro Val Arg Val 
1               5                   10                  15      


Tyr Gly Pro Asp Cys Val Val Leu Met Glu Pro Pro Leu Ser Lys Arg 
            20                  25                  30          


Asn Pro Pro Ala Leu Arg Leu Ala Asp Leu Ala Thr Ala Gln Val Gln 
        35                  40                  45              


Pro Leu Gln Asn Met Thr Gly Phe Pro Ala Leu Ala Gly Pro Pro Ala 
    50                  55                  60                  


His Ser Gln Leu Arg Ala Ala Val Ala His Leu Arg Leu Arg Asp Leu 
65                  70                  75                  80  


Gly Ala Asp Pro Gly Val Ala Thr Thr Pro Leu Gly Pro Glu His Met 
                85                  90                  95      


Ala Gln Ala Ser Thr Leu Gly Leu Ser Pro Pro Ser Gln Ala Phe Pro 
            100                 105                 110         


Ala His Pro Glu Ala Pro Ala Ala Ala Ala Arg Ala Ala Ala Leu Val 
        115                 120                 125             


Ala His Pro Gly Ala Gly Ser Tyr Pro Cys Gly Gly Gly Ser Ser Gly 
    130                 135                 140                 


Ala Gln Pro Ser Ala Pro Pro Pro Pro Ala Pro Pro Leu Pro Pro Thr 
145                 150                 155                 160 


Pro Ser Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Leu Ser 
                165                 170                 175     


Gly Tyr Thr Thr Thr Asn Ser Gly Gly Gly Gly Ser Ser Gly Lys Gly 
            180                 185                 190         


His Ser Arg Asp Phe Val Leu Arg Arg Asp Leu Ser Ala Thr Ala Pro 
        195                 200                 205             


Ala Ala Ala Met His Gly Ala Pro Leu Gly Gly Glu Gln Arg Ser Gly 
    210                 215                 220                 


Thr Gly Ser Pro Gln His Pro Ala Pro Pro Pro His Ser Ala Gly Met 
225                 230                 235                 240 


Phe Ile Ser Ala Ser Gly Thr Tyr Ala Gly Pro Asp Gly Ser Gly Gly 
                245                 250                 255     


Pro Ala Leu Phe Pro Ala Leu His Asp Thr Pro Gly Ala Pro Gly Gly 
            260                 265                 270         


His Pro His Pro Leu Asn Gly Gln Met Arg Leu Gly Leu Ala Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Ala Ala Glu Leu Tyr Gly Arg Ala Glu Pro Pro Phe 
    290                 295                 300                 


Ala Pro Arg Ser Gly Asp Ala His Tyr Gly Ala Val Ala Ala Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Leu His Gly Tyr Gly Ala Val Asn Leu Asn Leu Asn Leu 
                325                 330                 335     


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Pro Gly Pro His Leu Gln 
            340                 345                 350         


His His Ala Pro Pro Pro Ala Pro Pro Pro Pro Pro Ala Pro Ala Gln 
        355                 360                 365             


His Pro His Gln His His Pro His Leu Pro Gly Ala Ala Gly Ala Phe 
    370                 375                 380                 


Leu Arg Tyr Met Arg Gln Pro Ile Lys Gln Glu Leu Ile Cys Lys Trp 
385                 390                 395                 400 


Ile Asp Pro Asp Glu Leu Ala Gly Leu Pro Pro Pro Pro Pro Pro Pro 
                405                 410                 415     


Pro Pro Pro Pro Pro Pro Pro Pro Ala Gly Gly Ala Lys Pro Cys Ser 
            420                 425                 430         


Lys Thr Phe Gly Thr Met His Glu Leu Val Asn His Val Thr Val Glu 
        435                 440                 445             


His Val Gly Gly Pro Glu Gln Ser Ser His Val Cys Phe Trp Glu Asp 
    450                 455                 460                 


Cys Pro Arg Glu Gly Lys Pro Phe Lys Ala Lys Tyr Lys Leu Ile Asn 
465                 470                 475                 480 


His Ile Arg Val His Thr Gly Glu Lys Pro Phe Pro Cys Pro Phe Pro 
                485                 490                 495     


Gly Cys Gly Lys Val Phe Ala Arg Ser Glu Asn Leu Lys Ile His Lys 
            500                 505                 510         


Arg Thr His Thr Gly Glu Lys Pro Phe Lys Cys Glu Phe Asp Gly Cys 
        515                 520                 525             


Asp Arg Lys Phe Ala Asn Ser Ser Asp Arg Lys Lys His Ser His Val 
    530                 535                 540                 


His Thr Ser Asp Lys Pro Tyr Tyr Cys Lys Ile Arg Gly Cys Asp Lys 
545                 550                 555                 560 


Ser Tyr Thr His Pro Ser Ser Leu Arg Lys His Met Lys Ile His Cys 
                565                 570                 575     


Lys Ser Pro Pro Pro Ser Pro Gly Pro Leu Gly Tyr Ser Ser Val Gly 
            580                 585                 590         


Thr Pro Val Gly Ala Pro Leu Ser Pro Val Leu Asp Pro Ala Arg Ser 
        595                 600                 605             


His Ser Ser Thr Leu Ser Pro Gln Val Thr Asn Leu Asn Glu Trp Tyr 
    610                 615                 620                 


Val Cys Gln Ala Ser Gly Ala Pro Ser His Leu His Thr Pro Ser Ser 
625                 630                 635                 640 


Asn Gly Thr Thr Ser Glu Thr Glu Asp Glu Glu Ile Tyr Gly Asn Pro 
                645                 650                 655     


Glu Val Val Arg Thr Ile His 
            660             


