                         SEQUENCE LISTING

<110>  UNIVERSITY OF MANITOBA
       SOUSSI GOUNNI, Abdelilah
 
<120>  METHODS FOR USING SEMAPHORIN POLYPEPTIDES

<130>  352.00150201

<140>  PCT/IB2012/000627
<141>  2012-03-28

<150>  US 61/469,441
<151>  2011-03-30

<150>  US 61/554,075
<151>  2011-11-01

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Ala Gly His Ile Ile Thr Leu Leu Leu Trp Gly Tyr Leu 
1               5                   10                  15      


Leu Glu Leu Trp Thr Gly Gly His Thr Ala Asp Thr Thr His Pro Arg 
            20                  25                  30          


Leu Arg Leu Ser His Lys Glu Leu Leu Asn Leu Asn Arg Thr Ser Ile 
        35                  40                  45              


Phe His Ser Pro Phe Gly Phe Leu Asp Leu His Thr Met Leu Leu Asp 
    50                  55                  60                  


Glu Tyr Gln Glu Arg Leu Phe Val Gly Gly Arg Asp Leu Val Tyr Ser 
65                  70                  75                  80  


Leu Ser Leu Glu Arg Ile Ser Asp Gly Tyr Lys Glu Ile His Trp Pro 
                85                  90                  95      


Ser Thr Ala Leu Lys Met Glu Glu Cys Ile Met Lys Gly Lys Asp Ala 
            100                 105                 110         


Gly Glu Cys Ala Asn Tyr Val Arg Val Leu His His Tyr Asn Arg Thr 
        115                 120                 125             


His Leu Leu Thr Cys Gly Thr Gly Ala Phe Asp Pro Val Cys Ala Phe 
    130                 135                 140                 


Ile Arg Val Gly Tyr His Leu Glu Asp Pro Leu Phe His Leu Glu Ser 
145                 150                 155                 160 


Pro Arg Ser Glu Arg Gly Arg Gly Arg Cys Pro Phe Asp Pro Ser Ser 
                165                 170                 175     


Ser Phe Ile Ser Thr Leu Ile Gly Ser Glu Leu Phe Ala Gly Leu Tyr 
            180                 185                 190         


Ser Asp Tyr Trp Ser Arg Asp Ala Ala Ile Phe Arg Ser Met Gly Pro 
        195                 200                 205             


Leu Ala His Ile Arg Thr Glu His Asp Asp Glu Arg Leu Leu Lys Glu 
    210                 215                 220                 


Pro Lys Phe Val Gly Ser Tyr Met Ile Pro Asp Asn Glu Asp Arg Asp 
225                 230                 235                 240 


Asp Asn Lys Val Tyr Phe Phe Phe Thr Glu Lys Ala Leu Glu Ala Glu 
                245                 250                 255     


Asn Asn Ala His Ala Ile Tyr Thr Arg Val Gly Arg Leu Cys Val Asn 
            260                 265                 270         


Asp Val Gly Gly Gln Arg Ile Leu Val Asn Lys Trp Ser Thr Phe Leu 
        275                 280                 285             


Lys Ala Arg Leu Val Cys Ser Val Pro Gly Met Asn Gly Ile Asp Thr 
    290                 295                 300                 


Tyr Phe Asp Glu Leu Glu Asp Val Phe Leu Leu Pro Thr Arg Asp His 
305                 310                 315                 320 


Lys Asn Pro Val Ile Phe Gly Leu Phe Asn Thr Thr Ser Asn Ile Phe 
                325                 330                 335     


Arg Gly His Ala Ile Cys Val Tyr His Met Ser Ser Ile Arg Ala Ala 
            340                 345                 350         


Phe Asn Gly Pro Tyr Ala His Lys Glu Gly Pro Glu Tyr His Trp Ser 
        355                 360                 365             


Val Tyr Glu Gly Lys Val Pro Tyr Pro Arg Pro Gly Ser Cys Ala Ser 
    370                 375                 380                 


Lys Val Asn Gly Gly Arg Tyr Gly Thr Thr Lys Asp Tyr Pro Asp Asp 
385                 390                 395                 400 


Ala Ile Arg Phe Ala Arg Ser His Pro Leu Met Tyr Gln Ala Ile Lys 
                405                 410                 415     


Pro Ala His Lys Lys Pro Ile Leu Val Lys Thr Asp Gly Lys Tyr Asn 
            420                 425                 430         


Leu Lys Gln Ile Ala Val Asp Arg Val Glu Ala Glu Asp Gly Gln Tyr 
        435                 440                 445             


Asp Val Leu Phe Ile Gly Thr Asp Asn Gly Ile Val Leu Lys Val Ile 
    450                 455                 460                 


Thr Ile Tyr Asn Gln Glu Met Glu Ser Met Glu Glu Val Ile Leu Glu 
465                 470                 475                 480 


Glu Leu Gln Ile Phe Lys Asp Pro Val Pro Ile Ile Ser Met Glu Ile 
                485                 490                 495     


Ser Ser Lys Arg Gln Gln Leu Tyr Ile Gly Ser Ala Ser Ala Val Ala 
            500                 505                 510         


Gln Val Arg Phe His His Cys Asp Met Tyr Gly Ser Ala Cys Ala Asp 
        515                 520                 525             


Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ile Ser Cys 
    530                 535                 540                 


Ser Arg Tyr Tyr Pro Thr Gly Thr His Ala Lys Arg Arg Phe Arg Arg 
545                 550                 555                 560 


Gln Asp Val Arg His Gly Asn Ala Ala Gln Gln Cys Phe Gly Gln Gln 
                565                 570                 575     


Phe Val Gly Asp Ala Leu Asp Lys Thr Glu Glu His Leu Ala Tyr Gly 
            580                 585                 590         


Ile Glu Asn Asn Ser Thr Leu Leu Glu Cys Thr Pro Arg Ser Leu Gln 
        595                 600                 605             


Ala Lys Val Ile Trp Phe Val Gln Lys Gly Arg Glu Thr Arg Lys Glu 
    610                 615                 620                 


Glu Val Lys Thr Asp Asp Arg Val Val Lys Met Asp Leu Gly Leu Leu 
625                 630                 635                 640 


Phe Leu Arg Leu His Lys Ser Asp Ala Gly Thr Tyr Phe Cys Gln Thr 
                645                 650                 655     


Val Glu His Ser Phe Val His Thr Val Arg Lys Ile Thr Leu Glu Val 
            660                 665                 670         


Val Glu Glu Glu Lys Val Glu Asp Met Phe Asn Lys Asp Asp Glu Glu 
        675                 680                 685             


Asp Arg His His Arg Met Pro Cys Pro Ala Gln Ser Ser Ile Ser Gln 
    690                 695                 700                 


Gly Ala Lys Pro Trp Tyr Lys Glu Phe Leu Gln Leu Ile Gly Tyr Ser 
705                 710                 715                 720 


Asn Phe Gln Arg Val Glu Glu Tyr Cys Glu Lys Val Trp Cys Thr Asp 
                725                 730                 735     


Arg Lys Arg Lys Lys Leu Lys Met Ser Pro Ser Lys Trp Lys Tyr Ala 
            740                 745                 750         


Asn Pro Gln Glu Lys Lys Leu Arg Ser Lys Pro Glu His Tyr Arg Leu 
        755                 760                 765             


Pro Arg His Thr Leu Asp Ser 
    770                 775 


<210>  2
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  2

Thr Ala Asp Thr Thr His Pro Arg Leu Arg Leu Ser His Lys Glu Leu 
1               5                   10                  15      


Leu Asn Leu Asn Arg Thr Ser Ile Phe His Ser Pro Phe Gly Phe Leu 
            20                  25                  30          


Asp Leu His Thr Met Leu Leu Asp Glu Tyr Gln Glu Arg Leu Phe Val 
        35                  40                  45              


Gly Gly Arg Asp Leu Val Tyr Ser Leu Ser Leu Glu Arg Ile Ser Asp 
    50                  55                  60                  


Gly Tyr Lys Glu Ile His Trp Pro Ser Thr Ala Leu Lys Met Glu Glu 
65                  70                  75                  80  


Cys Ile Met Lys Gly Lys Asp Ala Gly Glu Cys Ala Asn Tyr Val Arg 
                85                  90                  95      


Val Leu His His Tyr Asn Arg Thr His Leu Leu Thr Cys Gly Thr Gly 
            100                 105                 110         


Ala Phe Asp Pro Val Cys Ala Phe Ile Arg Val Gly Tyr His Leu Glu 
        115                 120                 125             


Asp Pro Leu Phe His Leu Glu Ser Pro Arg Ser Glu Arg Gly Arg Gly 
    130                 135                 140                 


Arg Cys Pro Phe Asp Pro Ser Ser Ser Phe Ile Ser Thr Leu Ile Gly 
145                 150                 155                 160 


Ser Glu Leu Phe Ala Gly Leu Tyr Ser Asp Tyr Trp Ser Arg Asp Ala 
                165                 170                 175     


Ala Ile Phe Arg Ser Met Gly Pro Leu Ala His Ile Arg Thr Glu His 
            180                 185                 190         


Asp Asp Glu Arg Leu Leu Lys Glu Pro Lys Phe Val Gly Ser Tyr Met 
        195                 200                 205             


Ile Pro Asp Asn Glu Asp Arg Asp Asp Asn Lys Val Tyr Phe Phe Phe 
    210                 215                 220                 


Thr Glu Lys Ala Leu Glu Ala Glu Asn Asn Ala His Ala Ile Tyr Thr 
225                 230                 235                 240 


Arg Val Gly Arg Leu Cys Val Asn Asp Val Gly Gly Gln Arg Ile Leu 
                245                 250                 255     


Val Asn Lys Trp Ser Thr Phe Leu Lys Ala Arg Leu Val Cys Ser Val 
            260                 265                 270         


Pro Gly Met Asn Gly Ile Asp Thr Tyr Phe Asp Glu Leu Glu Asp Val 
        275                 280                 285             


Phe Leu Leu Pro Thr Arg Asp His Lys Asn Pro Val Ile Phe Gly Leu 
    290                 295                 300                 


Phe Asn Thr Thr Ser Asn Ile Phe Arg Gly His Ala Ile Cys Val Tyr 
305                 310                 315                 320 


His Met Ser Ser Ile Arg Ala Ala Phe Asn Gly Pro Tyr Ala His Lys 
                325                 330                 335     


Glu Gly Pro Glu Tyr His Trp Ser Val Tyr Glu Gly Lys Val Pro Tyr 
            340                 345                 350         


Pro Arg Pro Gly Ser Cys Ala Ser Lys Val Asn Gly Gly Arg Tyr Gly 
        355                 360                 365             


Thr Thr Lys Asp Tyr Pro Asp Asp Ala Ile Arg Phe Ala Arg Ser His 
    370                 375                 380                 


Pro Leu Met Tyr Gln Ala Ile Lys Pro Ala His Lys Lys Pro Ile Leu 
385                 390                 395                 400 


Val Lys Thr Asp Gly Lys Tyr Asn Leu Lys Gln Ile Ala Val Asp Arg 
                405                 410                 415     


Val Glu Ala Glu Asp Gly Gln Tyr Asp Val Leu Phe Ile Gly Thr Asp 
            420                 425                 430         


Asn Gly Ile Val Leu Lys Val Ile Thr Ile Tyr Asn Gln Glu Met Glu 
        435                 440                 445             


Ser Met Glu Glu Val Ile Leu Glu Glu Leu Gln Ile Phe Lys Asp Pro 
    450                 455                 460                 


Val Pro Ile Ile Ser Met Glu Ile Ser Ser Lys Arg Gln Gln Leu Tyr 
465                 470                 475                 480 


Ile Gly Ser Ala Ser Ala Val Ala Gln Val Arg Phe His His Cys Asp 
                485                 490                 495     


Met Tyr Gly Ser Ala Cys Ala Asp Cys Cys Leu Ala Arg Asp Pro Tyr 
            500                 505                 510         


Cys Ala Trp Asp Gly Ile Ser Cys Ser Arg Tyr Tyr Pro Thr Gly Thr 
        515                 520                 525             


His Ala Lys Arg Arg Phe Arg Arg Gln Asp Val Arg His Gly Asn Ala 
    530                 535                 540                 


Ala Gln Gln Cys Phe Gly Gln Gln Phe Val Gly Asp Ala Leu Asp Lys 
545                 550                 555                 560 


Thr Glu Glu His Leu Ala Tyr Gly Ile Glu Asn Asn Ser Thr Leu Leu 
                565                 570                 575     


Glu Cys Thr Pro Arg Ser Leu Gln Ala Lys Val Ile Trp Phe Val Gln 
            580                 585                 590         


Lys Gly Arg Glu Thr Arg Lys Glu Glu Val Lys Thr Asp Asp Arg Val 
        595                 600                 605             


Val Lys Met Asp Leu Gly Leu Leu Phe Leu Arg Leu His Lys Ser Asp 
    610                 615                 620                 


Ala Gly Thr Tyr Phe Cys Gln Thr Val Glu His Ser Phe Val His Thr 
625                 630                 635                 640 


Val Arg Lys Ile Thr Leu Glu Val Val Glu Glu Glu Lys Val Glu Asp 
                645                 650                 655     


Met Phe Asn Lys Asp Asp Glu Glu Asp Arg His His Arg Met Pro Cys 
            660                 665                 670         


Pro Ala Gln Ser Ser Ile Ser Gln Gly Ala Lys Pro Trp Tyr Lys Glu 
        675                 680                 685             


Phe Leu Gln Leu Ile Gly Tyr Ser Asn Phe Gln Arg Val Glu Glu Tyr 
    690                 695                 700                 


Cys Glu Lys Val Trp Cys Thr Asp Arg Lys Arg Lys Lys Leu Lys Met 
705                 710                 715                 720 


Ser Pro Ser Lys Trp Lys Tyr Ala Asn Pro Gln Glu Lys Lys Leu Arg 
                725                 730                 735     


Ser Lys Pro Glu His Tyr 
            740         


<210>  3
<211>  775
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ala Pro Ala Gly His Ile Leu Thr Leu Leu Leu Trp Gly His Leu 
1               5                   10                  15      


Leu Glu Leu Trp Thr Pro Gly His Ser Ala Asn Pro Ser Tyr Pro Arg 
            20                  25                  30          


Leu Arg Leu Ser His Lys Glu Leu Leu Glu Leu Asn Arg Thr Ser Ile 
        35                  40                  45              


Phe Gln Ser Pro Leu Gly Phe Leu Asp Leu His Thr Met Leu Leu Asp 
    50                  55                  60                  


Glu Tyr Gln Glu Arg Leu Phe Val Gly Gly Arg Asp Leu Val Tyr Ser 
65                  70                  75                  80  


Leu Asn Leu Glu Arg Val Ser Asp Gly Tyr Arg Glu Ile Tyr Trp Pro 
                85                  90                  95      


Ser Thr Ala Val Lys Val Glu Glu Cys Ile Met Lys Gly Lys Asp Ala 
            100                 105                 110         


Asn Glu Cys Ala Asn Tyr Ile Arg Val Leu His His Tyr Asn Arg Thr 
        115                 120                 125             


His Leu Leu Thr Cys Ala Thr Gly Ala Phe Asp Pro His Cys Ala Phe 
    130                 135                 140                 


Ile Arg Val Gly His His Ser Glu Glu Pro Leu Phe His Leu Glu Ser 
145                 150                 155                 160 


His Arg Ser Glu Arg Gly Arg Gly Arg Cys Pro Phe Asp Pro Asn Ser 
                165                 170                 175     


Ser Phe Val Ser Thr Leu Val Gly Asn Glu Leu Phe Ala Gly Leu Tyr 
            180                 185                 190         


Ser Asp Tyr Trp Gly Arg Asp Ser Ala Ile Phe Arg Ser Met Gly Lys 
        195                 200                 205             


Leu Gly His Ile Arg Thr Glu His Asp Asp Glu Arg Leu Leu Lys Glu 
    210                 215                 220                 


Pro Lys Phe Val Gly Ser Tyr Met Ile Pro Asp Asn Glu Asp Arg Asp 
225                 230                 235                 240 


Asp Asn Lys Met Tyr Phe Phe Phe Thr Glu Lys Ala Leu Glu Ala Glu 
                245                 250                 255     


Asn Asn Ala His Thr Ile Tyr Thr Arg Val Gly Arg Leu Cys Val Asn 
            260                 265                 270         


Asp Met Gly Gly Gln Arg Ile Leu Val Asn Lys Trp Ser Thr Phe Leu 
        275                 280                 285             


Lys Ala Arg Leu Val Cys Ser Val Pro Gly Met Asn Gly Ile Asp Thr 
    290                 295                 300                 


Tyr Phe Asp Glu Leu Glu Asp Val Phe Leu Leu Pro Thr Arg Asp Pro 
305                 310                 315                 320 


Lys Asn Pro Val Ile Phe Gly Leu Phe Asn Thr Thr Ser Asn Ile Phe 
                325                 330                 335     


Arg Gly His Ala Val Cys Val Tyr His Met Ser Ser Ile Arg Glu Ala 
            340                 345                 350         


Phe Asn Gly Pro Tyr Ala His Lys Glu Gly Pro Glu Tyr His Trp Ser 
        355                 360                 365             


Leu Tyr Glu Gly Lys Val Pro Tyr Pro Arg Pro Gly Ser Cys Ala Ser 
    370                 375                 380                 


Lys Val Asn Gly Gly Lys Tyr Gly Thr Thr Lys Asp Tyr Pro Asp Asp 
385                 390                 395                 400 


Ala Ile Arg Phe Ala Arg Met His Pro Leu Met Tyr Gln Pro Ile Lys 
                405                 410                 415     


Pro Val His Lys Lys Pro Ile Leu Val Lys Thr Asp Gly Lys Tyr Asn 
            420                 425                 430         


Leu Arg Gln Leu Ala Val Asp Arg Val Glu Ala Glu Asp Gly Gln Tyr 
        435                 440                 445             


Asp Val Leu Phe Ile Gly Thr Asp Thr Gly Ile Val Leu Lys Val Ile 
    450                 455                 460                 


Thr Ile Tyr Asn Gln Glu Thr Glu Trp Met Glu Glu Val Ile Leu Glu 
465                 470                 475                 480 


Glu Leu Gln Ile Phe Lys Asp Pro Ala Pro Ile Ile Ser Met Glu Ile 
                485                 490                 495     


Ser Ser Lys Arg Gln Gln Leu Tyr Ile Gly Ser Ala Ser Ala Val Ala 
            500                 505                 510         


Gln Val Arg Phe His His Cys Asp Met Tyr Gly Ser Ala Cys Ala Asp 
        515                 520                 525             


Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ile Ser Cys 
    530                 535                 540                 


Ser Arg Tyr Tyr Pro Thr Gly Ala His Ala Lys Arg Arg Phe Arg Arg 
545                 550                 555                 560 


Gln Asp Val Arg His Gly Asn Ala Ala Gln Gln Cys Phe Gly Gln Gln 
                565                 570                 575     


Phe Val Gly Asp Ala Leu Asp Arg Thr Glu Glu Arg Leu Ala Tyr Gly 
            580                 585                 590         


Ile Glu Ser Asn Ser Thr Leu Leu Glu Cys Thr Pro Arg Ser Leu Gln 
        595                 600                 605             


Ala Lys Val Ile Trp Phe Val Gln Lys Gly Arg Asp Val Arg Lys Glu 
    610                 615                 620                 


Glu Val Lys Thr Asp Asp Arg Val Val Lys Met Asp Leu Gly Leu Leu 
625                 630                 635                 640 


Phe Leu Arg Val Arg Lys Ser Asp Ala Gly Thr Tyr Phe Cys Gln Thr 
                645                 650                 655     


Val Glu His Asn Phe Val His Thr Val Arg Lys Ile Thr Leu Glu Val 
            660                 665                 670         


Val Glu Glu His Lys Val Glu Gly Met Phe His Lys Asp His Glu Glu 
        675                 680                 685             


Glu Arg His His Lys Met Pro Cys Pro Pro Leu Ser Gly Met Ser Gln 
    690                 695                 700                 


Gly Thr Lys Pro Trp Tyr Lys Glu Phe Leu Gln Leu Ile Gly Tyr Ser 
705                 710                 715                 720 


Asn Phe Gln Arg Val Glu Glu Tyr Cys Glu Lys Val Trp Cys Thr Asp 
                725                 730                 735     


Lys Lys Arg Lys Lys Leu Lys Met Ser Pro Ser Lys Trp Lys Tyr Ala 
            740                 745                 750         


Asn Pro Gln Glu Lys Arg Leu Arg Ser Lys Ala Glu His Phe Arg Leu 
        755                 760                 765             


Pro Arg His Thr Leu Leu Ser 
    770                 775 


<210>  4
<211>  741
<212>  PRT
<213>  Mus musculus

<400>  4

Ala Asn Pro Ser Tyr Pro Arg Leu Arg Leu Ser His Lys Glu Leu Leu 
1               5                   10                  15      


Glu Leu Asn Arg Thr Ser Ile Phe Gln Ser Pro Leu Gly Phe Leu Asp 
            20                  25                  30          


Leu His Thr Met Leu Leu Asp Glu Tyr Gln Glu Arg Leu Phe Val Gly 
        35                  40                  45              


Gly Arg Asp Leu Val Tyr Ser Leu Asn Leu Glu Arg Val Ser Asp Gly 
    50                  55                  60                  


Tyr Arg Glu Ile Tyr Trp Pro Ser Thr Ala Val Lys Val Glu Glu Cys 
65                  70                  75                  80  


Ile Met Lys Gly Lys Asp Ala Asn Glu Cys Ala Asn Tyr Ile Arg Val 
                85                  90                  95      


Leu His His Tyr Asn Arg Thr His Leu Leu Thr Cys Ala Thr Gly Ala 
            100                 105                 110         


Phe Asp Pro His Cys Ala Phe Ile Arg Val Gly His His Ser Glu Glu 
        115                 120                 125             


Pro Leu Phe His Leu Glu Ser His Arg Ser Glu Arg Gly Arg Gly Arg 
    130                 135                 140                 


Cys Pro Phe Asp Pro Asn Ser Ser Phe Val Ser Thr Leu Val Gly Asn 
145                 150                 155                 160 


Glu Leu Phe Ala Gly Leu Tyr Ser Asp Tyr Trp Gly Arg Asp Ser Ala 
                165                 170                 175     


Ile Phe Arg Ser Met Gly Lys Leu Gly His Ile Arg Thr Glu His Asp 
            180                 185                 190         


Asp Glu Arg Leu Leu Lys Glu Pro Lys Phe Val Gly Ser Tyr Met Ile 
        195                 200                 205             


Pro Asp Asn Glu Asp Arg Asp Asp Asn Lys Met Tyr Phe Phe Phe Thr 
    210                 215                 220                 


Glu Lys Ala Leu Glu Ala Glu Asn Asn Ala His Thr Ile Tyr Thr Arg 
225                 230                 235                 240 


Val Gly Arg Leu Cys Val Asn Asp Met Gly Gly Gln Arg Ile Leu Val 
                245                 250                 255     


Asn Lys Trp Ser Thr Phe Leu Lys Ala Arg Leu Val Cys Ser Val Pro 
            260                 265                 270         


Gly Met Asn Gly Ile Asp Thr Tyr Phe Asp Glu Leu Glu Asp Val Phe 
        275                 280                 285             


Leu Leu Pro Thr Arg Asp Pro Lys Asn Pro Val Ile Phe Gly Leu Phe 
    290                 295                 300                 


Asn Thr Thr Ser Asn Ile Phe Arg Gly His Ala Val Cys Val Tyr His 
305                 310                 315                 320 


Met Ser Ser Ile Arg Glu Ala Phe Asn Gly Pro Tyr Ala His Lys Glu 
                325                 330                 335     


Gly Pro Glu Tyr His Trp Ser Leu Tyr Glu Gly Lys Val Pro Tyr Pro 
            340                 345                 350         


Arg Pro Gly Ser Cys Ala Ser Lys Val Asn Gly Gly Lys Tyr Gly Thr 
        355                 360                 365             


Thr Lys Asp Tyr Pro Asp Asp Ala Ile Arg Phe Ala Arg Met His Pro 
    370                 375                 380                 


Leu Met Tyr Gln Pro Ile Lys Pro Val His Lys Lys Pro Ile Leu Val 
385                 390                 395                 400 


Lys Thr Asp Gly Lys Tyr Asn Leu Arg Gln Leu Ala Val Asp Arg Val 
                405                 410                 415     


Glu Ala Glu Asp Gly Gln Tyr Asp Val Leu Phe Ile Gly Thr Asp Thr 
            420                 425                 430         


Gly Ile Val Leu Lys Val Ile Thr Ile Tyr Asn Gln Glu Thr Glu Trp 
        435                 440                 445             


Met Glu Glu Val Ile Leu Glu Glu Leu Gln Ile Phe Lys Asp Pro Ala 
    450                 455                 460                 


Pro Ile Ile Ser Met Glu Ile Ser Ser Lys Arg Gln Gln Leu Tyr Ile 
465                 470                 475                 480 


Gly Ser Ala Ser Ala Val Ala Gln Val Arg Phe His His Cys Asp Met 
                485                 490                 495     


Tyr Gly Ser Ala Cys Ala Asp Cys Cys Leu Ala Arg Asp Pro Tyr Cys 
            500                 505                 510         


Ala Trp Asp Gly Ile Ser Cys Ser Arg Tyr Tyr Pro Thr Gly Ala His 
        515                 520                 525             


Ala Lys Arg Arg Phe Arg Arg Gln Asp Val Arg His Gly Asn Ala Ala 
    530                 535                 540                 


Gln Gln Cys Phe Gly Gln Gln Phe Val Gly Asp Ala Leu Asp Arg Thr 
545                 550                 555                 560 


Glu Glu Arg Leu Ala Tyr Gly Ile Glu Ser Asn Ser Thr Leu Leu Glu 
                565                 570                 575     


Cys Thr Pro Arg Ser Leu Gln Ala Lys Val Ile Trp Phe Val Gln Lys 
            580                 585                 590         


Gly Arg Asp Val Arg Lys Glu Glu Val Lys Thr Asp Asp Arg Val Val 
        595                 600                 605             


Lys Met Asp Leu Gly Leu Leu Phe Leu Arg Val Arg Lys Ser Asp Ala 
    610                 615                 620                 


Gly Thr Tyr Phe Cys Gln Thr Val Glu His Asn Phe Val His Thr Val 
625                 630                 635                 640 


Arg Lys Ile Thr Leu Glu Val Val Glu Glu His Lys Val Glu Gly Met 
                645                 650                 655     


Phe His Lys Asp His Glu Glu Glu Arg His His Lys Met Pro Cys Pro 
            660                 665                 670         


Pro Leu Ser Gly Met Ser Gln Gly Thr Lys Pro Trp Tyr Lys Glu Phe 
        675                 680                 685             


Leu Gln Leu Ile Gly Tyr Ser Asn Phe Gln Arg Val Glu Glu Tyr Cys 
    690                 695                 700                 


Glu Lys Val Trp Cys Thr Asp Lys Lys Arg Lys Lys Leu Lys Met Ser 
705                 710                 715                 720 


Pro Ser Lys Trp Lys Tyr Ala Asn Pro Gln Glu Lys Arg Leu Arg Ser 
                725                 730                 735     


Lys Ala Glu His Phe 
            740     


<210>  5
<211>  775
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Met Ala Pro Thr Gly His Ile Leu Thr Leu Leu Leu Trp Gly His Leu 
1               5                   10                  15      


Leu Glu Leu Trp Thr Pro Gly Tyr Thr Ala Asn Pro Ser Tyr Pro Arg 
            20                  25                  30          


Leu Arg Leu Ser His Lys Glu Leu Leu Glu Leu Asn Arg Thr Ser Ile 
        35                  40                  45              


Phe Gln Ser Pro Phe Gly Phe Leu Asp Leu His Thr Met Leu Leu Asp 
    50                  55                  60                  


Glu Tyr Gln Glu Arg Leu Phe Val Gly Gly Arg Asp Leu Val Tyr Ser 
65                  70                  75                  80  


Leu Asn Leu Glu Arg Val Ser Asp Gly Tyr Arg Glu Ile Tyr Trp Pro 
                85                  90                  95      


Ser Thr Ala Val Lys Val Glu Glu Cys Ile Met Lys Gly Lys Asp Ala 
            100                 105                 110         


Asn Glu Cys Ala Asn Tyr Val Arg Val Leu His His Tyr Asn Arg Thr 
        115                 120                 125             


His Leu Leu Thr Cys Ala Thr Gly Ala Phe Asp Pro His Cys Ala Phe 
    130                 135                 140                 


Ile Arg Val Gly His His Ser Glu Asp Pro Leu Phe His Leu Glu Ser 
145                 150                 155                 160 


His Arg Ser Glu Arg Gly Arg Gly Arg Cys Pro Phe Asp Pro Asn Ser 
                165                 170                 175     


Ser Phe Val Ser Thr Leu Val Gly Asn Glu Leu Phe Ala Gly Leu Tyr 
            180                 185                 190         


Ser Asp Tyr Trp Gly Arg Asp Ser Ala Ile Phe Arg Ser Leu Gly Lys 
        195                 200                 205             


Leu Gly His Ile Arg Thr Glu His Asp Asp Glu Arg Leu Leu Lys Glu 
    210                 215                 220                 


Pro Lys Phe Val Gly Ser Tyr Met Ile Pro Asp Asn Glu Asp Pro Glu 
225                 230                 235                 240 


Asp Asn Lys Met Tyr Phe Phe Phe Thr Glu Lys Ala Leu Glu Ala Glu 
                245                 250                 255     


Asn Asn Ala His Thr Ile Tyr Thr Arg Val Gly Arg Leu Cys Val Asn 
            260                 265                 270         


Asp Met Gly Gly Gln Arg Ile Leu Val Asn Lys Trp Ser Thr Phe Leu 
        275                 280                 285             


Lys Ala Arg Leu Val Cys Ser Val Pro Gly Met Asn Gly Ile Asp Thr 
    290                 295                 300                 


His Phe Asp Glu Leu Glu Asp Val Phe Leu Leu Pro Thr Arg Asp Pro 
305                 310                 315                 320 


Lys Asn Pro Val Ile Phe Gly Leu Phe Asn Thr Thr Ser Asn Ile Phe 
                325                 330                 335     


Arg Gly His Ala Val Cys Val Tyr His Met Ser Ser Ile Arg Glu Ala 
            340                 345                 350         


Phe Asn Gly Pro Tyr Ala His Lys Glu Gly Pro Glu Tyr His Trp Ser 
        355                 360                 365             


Leu Tyr Glu Gly Lys Val Pro Tyr Pro Arg Pro Gly Ser Cys Ala Ser 
    370                 375                 380                 


Lys Val Asn Gly Gly Lys Tyr Gly Ser Thr Lys Asp Tyr Pro Asp Asp 
385                 390                 395                 400 


Ala Ile Arg Phe Ala Arg Met His Pro Leu Met Tyr Gln Pro Ile Lys 
                405                 410                 415     


Pro Val His Lys Lys Pro Ile Leu Val Lys Thr Asp Gly Lys Tyr Asn 
            420                 425                 430         


Leu Arg Gln Leu Ala Val Asp Arg Val Glu Ala Glu Asp Gly Gln Tyr 
        435                 440                 445             


Asp Val Leu Phe Ile Gly Thr Asp Thr Gly Ile Val Leu Lys Val Ile 
    450                 455                 460                 


Thr Ile Tyr Asn Gln Glu Thr Glu Trp Met Glu Glu Val Ile Leu Glu 
465                 470                 475                 480 


Glu Leu Gln Ile Phe Lys Asp Pro Ala Pro Ile Ile Ser Met Glu Ile 
                485                 490                 495     


Ser Ser Lys Arg Gln Gln Leu Tyr Ile Gly Ser Ala Ser Ala Val Ala 
            500                 505                 510         


Gln Val Arg Phe His His Cys Asp Met Tyr Gly Ser Ala Cys Ala Asp 
        515                 520                 525             


Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ile Ser Cys 
    530                 535                 540                 


Ser Arg Tyr Tyr Pro Thr Gly Ala His Ser Lys Arg Arg Phe Arg Arg 
545                 550                 555                 560 


Gln Asp Val Arg His Gly Asn Ala Ala Gln Gln Cys Phe Gly Gln Gln 
                565                 570                 575     


Phe Val Gly Asp Ala Leu Asp Arg Thr Glu Glu Arg Leu Ala Tyr Gly 
            580                 585                 590         


Ile Glu Ser Asn Ser Thr Leu Leu Glu Cys Thr Pro Arg Ser Leu Gln 
        595                 600                 605             


Ala Lys Val Val Trp Phe Val Gln Lys Gly Arg Asp Val Arg Lys Glu 
    610                 615                 620                 


Glu Val Lys Thr Asp Asp Arg Val Val Lys Met Asp Leu Gly Leu Leu 
625                 630                 635                 640 


Phe Leu Arg Val Arg Lys Ser Asp Ala Gly Thr Tyr Phe Cys Gln Thr 
                645                 650                 655     


Val Glu His Ser Phe Val His Thr Val Arg Lys Ile Thr Leu Glu Val 
            660                 665                 670         


Val Glu Glu His Lys Val Glu Gly Met Phe His Lys Asp Arg Glu Glu 
        675                 680                 685             


Glu Lys His His Lys Met Pro Cys Pro Pro Leu Thr Gly Met Ser Gln 
    690                 695                 700                 


Gly Thr Lys Pro Trp Tyr Lys Glu Phe Leu Gln Leu Ile Gly Tyr Ser 
705                 710                 715                 720 


Asn Phe Gln Arg Val Glu Glu Tyr Cys Glu Lys Val Trp Cys Thr Asp 
                725                 730                 735     


Lys Lys Arg Lys Lys Leu Lys Met Ser Pro Ser Lys Trp Lys Tyr Ala 
            740                 745                 750         


Asn Pro Gln Glu Lys Arg Leu Arg Ser Lys Ala Glu His Phe Arg Leu 
        755                 760                 765             


Pro Arg His Thr Leu Val Ser 
    770                 775 


<210>  6
<211>  741
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Ala Asn Pro Ser Tyr Pro Arg Leu Arg Leu Ser His Lys Glu Leu Leu 
1               5                   10                  15      


Glu Leu Asn Arg Thr Ser Ile Phe Gln Ser Pro Phe Gly Phe Leu Asp 
            20                  25                  30          


Leu His Thr Met Leu Leu Asp Glu Tyr Gln Glu Arg Leu Phe Val Gly 
        35                  40                  45              


Gly Arg Asp Leu Val Tyr Ser Leu Asn Leu Glu Arg Val Ser Asp Gly 
    50                  55                  60                  


Tyr Arg Glu Ile Tyr Trp Pro Ser Thr Ala Val Lys Val Glu Glu Cys 
65                  70                  75                  80  


Ile Met Lys Gly Lys Asp Ala Asn Glu Cys Ala Asn Tyr Val Arg Val 
                85                  90                  95      


Leu His His Tyr Asn Arg Thr His Leu Leu Thr Cys Ala Thr Gly Ala 
            100                 105                 110         


Phe Asp Pro His Cys Ala Phe Ile Arg Val Gly His His Ser Glu Asp 
        115                 120                 125             


Pro Leu Phe His Leu Glu Ser His Arg Ser Glu Arg Gly Arg Gly Arg 
    130                 135                 140                 


Cys Pro Phe Asp Pro Asn Ser Ser Phe Val Ser Thr Leu Val Gly Asn 
145                 150                 155                 160 


Glu Leu Phe Ala Gly Leu Tyr Ser Asp Tyr Trp Gly Arg Asp Ser Ala 
                165                 170                 175     


Ile Phe Arg Ser Leu Gly Lys Leu Gly His Ile Arg Thr Glu His Asp 
            180                 185                 190         


Asp Glu Arg Leu Leu Lys Glu Pro Lys Phe Val Gly Ser Tyr Met Ile 
        195                 200                 205             


Pro Asp Asn Glu Asp Pro Glu Asp Asn Lys Met Tyr Phe Phe Phe Thr 
    210                 215                 220                 


Glu Lys Ala Leu Glu Ala Glu Asn Asn Ala His Thr Ile Tyr Thr Arg 
225                 230                 235                 240 


Val Gly Arg Leu Cys Val Asn Asp Met Gly Gly Gln Arg Ile Leu Val 
                245                 250                 255     


Asn Lys Trp Ser Thr Phe Leu Lys Ala Arg Leu Val Cys Ser Val Pro 
            260                 265                 270         


Gly Met Asn Gly Ile Asp Thr His Phe Asp Glu Leu Glu Asp Val Phe 
        275                 280                 285             


Leu Leu Pro Thr Arg Asp Pro Lys Asn Pro Val Ile Phe Gly Leu Phe 
    290                 295                 300                 


Asn Thr Thr Ser Asn Ile Phe Arg Gly His Ala Val Cys Val Tyr His 
305                 310                 315                 320 


Met Ser Ser Ile Arg Glu Ala Phe Asn Gly Pro Tyr Ala His Lys Glu 
                325                 330                 335     


Gly Pro Glu Tyr His Trp Ser Leu Tyr Glu Gly Lys Val Pro Tyr Pro 
            340                 345                 350         


Arg Pro Gly Ser Cys Ala Ser Lys Val Asn Gly Gly Lys Tyr Gly Ser 
        355                 360                 365             


Thr Lys Asp Tyr Pro Asp Asp Ala Ile Arg Phe Ala Arg Met His Pro 
    370                 375                 380                 


Leu Met Tyr Gln Pro Ile Lys Pro Val His Lys Lys Pro Ile Leu Val 
385                 390                 395                 400 


Lys Thr Asp Gly Lys Tyr Asn Leu Arg Gln Leu Ala Val Asp Arg Val 
                405                 410                 415     


Glu Ala Glu Asp Gly Gln Tyr Asp Val Leu Phe Ile Gly Thr Asp Thr 
            420                 425                 430         


Gly Ile Val Leu Lys Val Ile Thr Ile Tyr Asn Gln Glu Thr Glu Trp 
        435                 440                 445             


Met Glu Glu Val Ile Leu Glu Glu Leu Gln Ile Phe Lys Asp Pro Ala 
    450                 455                 460                 


Pro Ile Ile Ser Met Glu Ile Ser Ser Lys Arg Gln Gln Leu Tyr Ile 
465                 470                 475                 480 


Gly Ser Ala Ser Ala Val Ala Gln Val Arg Phe His His Cys Asp Met 
                485                 490                 495     


Tyr Gly Ser Ala Cys Ala Asp Cys Cys Leu Ala Arg Asp Pro Tyr Cys 
            500                 505                 510         


Ala Trp Asp Gly Ile Ser Cys Ser Arg Tyr Tyr Pro Thr Gly Ala His 
        515                 520                 525             


Ser Lys Arg Arg Phe Arg Arg Gln Asp Val Arg His Gly Asn Ala Ala 
    530                 535                 540                 


Gln Gln Cys Phe Gly Gln Gln Phe Val Gly Asp Ala Leu Asp Arg Thr 
545                 550                 555                 560 


Glu Glu Arg Leu Ala Tyr Gly Ile Glu Ser Asn Ser Thr Leu Leu Glu 
                565                 570                 575     


Cys Thr Pro Arg Ser Leu Gln Ala Lys Val Val Trp Phe Val Gln Lys 
            580                 585                 590         


Gly Arg Asp Val Arg Lys Glu Glu Val Lys Thr Asp Asp Arg Val Val 
        595                 600                 605             


Lys Met Asp Leu Gly Leu Leu Phe Leu Arg Val Arg Lys Ser Asp Ala 
    610                 615                 620                 


Gly Thr Tyr Phe Cys Gln Thr Val Glu His Ser Phe Val His Thr Val 
625                 630                 635                 640 


Arg Lys Ile Thr Leu Glu Val Val Glu Glu His Lys Val Glu Gly Met 
                645                 650                 655     


Phe His Lys Asp Arg Glu Glu Glu Lys His His Lys Met Pro Cys Pro 
            660                 665                 670         


Pro Leu Thr Gly Met Ser Gln Gly Thr Lys Pro Trp Tyr Lys Glu Phe 
        675                 680                 685             


Leu Gln Leu Ile Gly Tyr Ser Asn Phe Gln Arg Val Glu Glu Tyr Cys 
    690                 695                 700                 


Glu Lys Val Trp Cys Thr Asp Lys Lys Arg Lys Lys Leu Lys Met Ser 
705                 710                 715                 720 


Pro Ser Lys Trp Lys Tyr Ala Asn Pro Gln Glu Lys Arg Leu Arg Ser 
                725                 730                 735     


Lys Ala Glu His Phe 
            740     


<210>  7
<211>  6
<212>  PRT
<213>  unknown

<220>
<223>  consensus site within sema3E polypeptide


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Lys Arg Arg Xaa Arg Arg 
1               5       


<210>  8
<211>  4
<212>  PRT
<213>  unknown

<220>
<223>  consensus site within sema3E polypeptide


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Arg Xaa Xaa Arg 
1               


