                         SEQUENCE LISTING

<110>  Queen Mary and Westfield College University of London
 
<120>  Polypeptide

<130>  P043727WO

<150>  GB 1106130.6
<151>  2011-04-11

<150>  GB 1112985.5
<151>  2011-07-28

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  856
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Ala Asp Lys Asn Gly Gly Ser Val Ser Ser Val Ser Ser 
1               5                   10                  15      


Ser Arg Leu Gln Ser Arg Lys Pro Pro Asn Leu Ser Ile Thr Ile Pro 
            20                  25                  30          


Pro Pro Glu Lys Glu Thr Gln Ala Pro Gly Glu Gln Asp Ser Met Leu 
        35                  40                  45              


Pro Glu Gly Phe Gln Asn Arg Arg Leu Lys Lys Ser Gln Pro Arg Thr 
    50                  55                  60                  


Trp Ala Ala His Thr Thr Ala Cys Pro Pro Ser Phe Leu Pro Lys Arg 
65                  70                  75                  80  


Lys Asn Pro Ala Tyr Leu Lys Ser Val Ser Leu Gln Glu Pro Arg Ser 
                85                  90                  95      


Arg Trp Gln Glu Ser Ser Glu Lys Arg Pro Gly Phe Arg Arg Gln Ala 
            100                 105                 110         


Ser Leu Ser Gln Ser Ile Arg Lys Gly Ala Ala Gln Trp Phe Gly Val 
        115                 120                 125             


Ser Gly Asp Trp Glu Gly Gln Arg Gln Gln Trp Gln Arg Arg Ser Leu 
    130                 135                 140                 


His His Cys Ser Met Arg Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg 
145                 150                 155                 160 


Asp Leu Glu Leu Pro Ser Gln Glu Ala Pro Ser Phe Gln Gly Thr Glu 
                165                 170                 175     


Ser Pro Lys Pro Cys Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
            180                 185                 190         


Gly Arg Ala Phe Arg His Pro Glu Glu Met Asp Arg Pro His Ala Pro 
        195                 200                 205             


His Pro Pro Leu Thr Pro Gly Val Leu Ser Leu Thr Ser Phe Thr Ser 
    210                 215                 220                 


Val Arg Ser Gly Tyr Ser His Leu Pro Arg Arg Lys Arg Met Ser Val 
225                 230                 235                 240 


Ala His Met Ser Leu Gln Ala Ala Ala Ala Leu Leu Lys Gly Arg Ser 
                245                 250                 255     


Val Leu Asp Ala Thr Gly Gln Arg Cys Arg Val Val Lys Arg Ser Phe 
            260                 265                 270         


Ala Phe Pro Ser Phe Leu Glu Glu Asp Val Val Asp Gly Ala Asp Thr 
        275                 280                 285             


Phe Asp Ser Ser Phe Phe Ser Lys Glu Glu Met Ser Ser Met Pro Asp 
    290                 295                 300                 


Asp Val Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe Arg Gly Ile 
305                 310                 315                 320 


Pro His Ser Ala Ser Pro Val Ser Pro Asp Gly Val Gln Ile Pro Leu 
                325                 330                 335     


Lys Glu Tyr Gly Arg Ala Pro Val Pro Gly Pro Arg Arg Gly Lys Arg 
            340                 345                 350         


Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg Lys Lys Arg His 
        355                 360                 365             


Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg Ser Tyr Arg Arg 
    370                 375                 380                 


Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser Phe Asp Ser His 
385                 390                 395                 400 


Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His Val Ile Ile Thr 
                405                 410                 415     


Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val Gly Phe Ala Gln 
            420                 425                 430         


His Val Thr Thr Gln Leu Val Leu Arg Asn Lys Gly Val Tyr Glu Ser 
        435                 440                 445             


Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Val Gly Pro Ser Ser Ile 
    450                 455                 460                 


Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Ile Arg Lys Asp 
465                 470                 475                 480 


Gly Gln Ile Glu Gln Leu Val Leu Arg Glu Arg Asp Leu Glu Arg Asp 
                485                 490                 495     


Ser Gly Cys Cys Val Gln Asn Asp His Ser Gly Cys Ile Gln Thr Gln 
            500                 505                 510         


Arg Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val Lys Trp Gln Asp 
        515                 520                 525             


Asp Thr Gly Pro Pro Met Asp Lys Ser Asp Leu Gly Gln Lys Arg Thr 
    530                 535                 540                 


Ser Gly Ala Val Cys His Gln Asp Pro Arg Thr Cys Glu Glu Pro Ala 
545                 550                 555                 560 


Ser Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys Trp Pro Ile 
                565                 570                 575     


Cys Thr Glu Gln Ala Arg Ser Asn His Thr Gly Phe Leu His Met Asp 
            580                 585                 590         


Cys Glu Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Ser Cys 
        595                 600                 605             


Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly Tyr Phe His 
    610                 615                 620                 


Glu Glu Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp Lys Val Cys 
625                 630                 635                 640 


Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg 
                645                 650                 655     


Leu Trp Leu Ser Leu Phe Leu His Ala Gly Val Val His Cys Leu Val 
            660                 665                 670         


Ser Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu Lys Leu Ala 
        675                 680                 685             


Gly Trp His Arg Ile Ala Ile Ile Phe Ile Leu Ser Gly Ile Thr Gly 
    690                 695                 700                 


Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro 
705                 710                 715                 720 


Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val Glu Leu Phe 
                725                 730                 735     


Gln Ser Trp Pro Leu Leu Glu Arg Pro Trp Lys Ala Phe Leu Asn Leu 
            740                 745                 750         


Ser Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu Pro Trp Ile 
        755                 760                 765             


Asp Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Leu Leu Leu Ala 
    770                 775                 780                 


Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp Lys Tyr Arg 
785                 790                 795                 800 


Lys Arg Ala Leu Ile Leu Val Ser Leu Leu Ala Phe Ala Gly Leu Phe 
                805                 810                 815     


Ala Ala Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn Trp Pro Trp 
            820                 825                 830         


Ile Glu His Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe Cys Glu Lys 
        835                 840                 845             


Tyr Glu Leu Asp Gln Val Leu His 
    850                 855     


<210>  2
<211>  3615
<212>  DNA
<213>  Homo sapiens

<400>  2
ccccgaggag ccaccgccca gccgctcgca ggcgccgcac ggagttgcgt cccggggact       60

tggggccgca gggagctgtg agtacccagg aagctgcacc gtgtggcctg gagctgtcta      120

tctgtccttc cagccacctg tctgtccagc cacccttcca cagactgagg cttgacaccg      180

gagcatctgt acagagcaag gagaagacaa gaacatgctc taaagccctt cacagcaaga      240

cccaggaagc cgcgggcaaa ctcagactcg aagccctccc gcctcctgcc cacaatggcc      300

tctgctgaca agaatggcgg gagcgtgtcc tctgtgtcca gcagccgcct gcagagccgg      360

aagccaccca acctctccat caccatcccg ccacccgaga aagagaccca ggcccctggc      420

gagcaggaca gcatgctgcc tgagggtttt cagaatagga ggctaaagaa aagccagccc      480

aggacctggg ctgcacacac caccgcctgc cctccctcct tcctccccaa gaggaagaac      540

ccagcctact tgaagagcgt cagcctccag gagccacgca gccgatggca ggagagttca      600

gagaagcgcc ctggcttccg ccgccaggcc tcactgtccc agagcatccg caagggcgca      660

gcccagtggt ttggagtcag cggcgactgg gaggggcagc ggcagcagtg gcagcgccgc      720

agcctgcacc actgcagcat gcgctacggc cgcctgaagg cctcgtgcca gcgtgacctg      780

gagctcccca gccaggaggc accgtccttc cagggcactg agtccccaaa gccctgcaag      840

atgcccaaga ttgtggatcc gctggcccgg ggccgggcct tccgccaccc ggaggagatg      900

gacaggcccc acgccccgca cccaccgctg acccccggag tcctgtccct cacctccttc      960

accagtgtcc gttctggcta ctcccacctg ccacgccgca agagaatgtc tgtggcccac     1020

atgagcttgc aagctgccgc tgccctcctc aaggggcgct cggtgctgga tgccaccgga     1080

cagcggtgcc gggtggtcaa gcgcagcttt gccttcccga gcttcctgga ggaggatgtg     1140

gtcgatgggg cagacacgtt tgactcctcc ttttttagta aggaagaaat gagctccatg     1200

cctgatgatg tctttgagtc ccccccactc tctgccagct acttccgagg gatcccacac     1260

tcagcctccc ctgtctcccc cgatggggtg caaatccctc tgaaggagta tggccgagcc     1320

ccagtccccg ggccccggcg cggcaagcgc atcgcctcca aggtgaagca ctttgccttt     1380

gatcggaaga agcggcacta cggcctcggc gtggtgggca actggctgaa ccgcagctac     1440

cgccgcagca tcagcagcac tgtgcagcgg cagctggaga gcttcgacag ccaccggccc     1500

tacttcacct actggctgac cttcgtccat gtcatcatca cgctgctggt gatttgcacg     1560

tatggcatcg cacccgtggg ctttgcccag cacgtcacca cccagctggt gctgcggaac     1620

aaaggtgtgt acgagagcgt gaagtacatc cagcaggaga acttctgggt tggccccagc     1680

tcgattgacc tgatccacct gggggccaag ttctcaccct gcatccggaa ggacgggcag     1740

atcgagcagc tggtgctgcg cgagcgagac ctggagcggg actcaggctg ctgtgtccag     1800

aatgaccact ccggatgcat ccagacccag cggaaggact gctcggagac tttggccact     1860

tttgtcaagt ggcaggatga cactgggccc cccatggaca agtctgatct gggccagaag     1920

cggacttcgg gggctgtctg ccaccaggac cccaggacct gcgaggagcc agcctccagc     1980

ggtgcccaca tctggcccga tgacatcact aagtggccga tctgcacaga gcaggccagg     2040

agcaaccaca caggcttcct gcacatggac tgcgagatca agggccgccc ctgctgcatc     2100

ggcaccaagg gcagctgtga gatcaccacc cgggaatact gtgagttcat gcacggctat     2160

ttccatgagg aagcaacact ctgctcccag gtgcactgct tggacaaggt gtgtgggctg     2220

ctgcccttcc tcaaccctga ggtcccagat cagttctaca ggctctggct gtctctcttc     2280

ctacatgctg gcgtggtgca ctgcctcgtg tctgtggtct ttcaaatgac catcctgagg     2340

gacctggaga agctggccgg ctggcaccgt atcgccatca tcttcatcct cagtggcatc     2400

acaggcaacc tcgccagtgc catctttctc ccataccggg cagaggtggg cccggccggc     2460

tcacagttcg gcctcctcgc ctgcctcttc gtggagctct tccagagctg gccgctgctg     2520

gagaggccct ggaaggcctt cctcaacctc tcggccatcg tgctcttcct gttcatctgt     2580

ggcctcctgc cctggatcga caacatcgcc cacatcttcg gcttcctcag tggcctgctg     2640

ctggccttcg ccttcctgcc ctacatcacc ttcggcacca gcgacaagta ccgcaagcgg     2700

gcactcatcc tggtgtcact gctggccttt gccggcctct tcgccgccct cgtgctgtgg     2760

ctgtacatct accccattaa ctggccctgg atcgagcacc tcacctgctt ccccttcacc     2820

agccgcttct gcgagaagta tgagctggac caggtgctgc actgaccgct gggccacacg     2880

gctgcccctc agccctgctg gaacagggtc tgcctgcgag ggctgccctc tgcagagcgc     2940

tctctgtgtg ccagagagcc agagacccaa gacagggccc gggctctgga cctgggtgcc     3000

cccctgccag gcgaggctga ctccgcgtga gatggttggt taaggcgggg tttttctggg     3060

gcgtgaggcc tgtgagatcc tgacccaagc tcaggcacac ccaaggcacc tgcctctctg     3120

agtcttgggt ctcagttcct aatatcccgc tccttgctga gaccatctcc tggggcaggg     3180

tccttttctt cccaggtcct cagcgctgcc tctgctggtg ccttctcccc cactactact     3240

ggagcgtgcc cttgctgggg acgtggctgt gccctcagtt gcccccaggg ctgggtgccc     3300

accatgcccc ttcctctttc tcctcctacc tctgccctgt gagcccatcc ataaggctct     3360

cagatgggac attgtgggaa aggctttggc catggtctgg gggcagagaa caagggggga     3420

gacacaagta gacctcaggt agaacgacac tgggcggagc caccccaggg cctgctccca     3480

gggagtgctc gaggcgcatc aggcccgttt tttaccagtt tatatcacgg tcttcatttt     3540

taaaagtaac gctaactttg tacggacgat gtctcatgga ttaaataata ttctttatgg     3600

cagtaaaaaa aaaaa                                                      3615


<210>  3
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ala Val His Asp Leu Glu Met Glu Ser Met Asn Leu Asn Met 
1               5                   10                  15      


Gly Arg Glu Met Lys Glu Glu Leu Glu Glu Glu Glu Lys Met Arg Glu 
            20                  25                  30          


Asp Gly Gly Gly Lys Asp Arg Ala Lys Ser Lys Lys Val His Arg Ile 
        35                  40                  45              


Val Ser Lys Trp Met Leu Pro Glu Lys Ser Arg Gly Thr Tyr Leu Glu 
    50                  55                  60                  


Arg Ala Asn Cys Phe Pro Pro Pro Val Phe Ile Ile Ser Ile Ser Leu 
65                  70                  75                  80  


Ala Glu Leu Ala Val Phe Ile Tyr Tyr Ala Val Trp Lys Pro Gln Lys 
                85                  90                  95      


Gln Trp Ile Thr Leu Asp Thr Gly Ile Leu Glu Ser Pro Phe Ile Tyr 
            100                 105                 110         


Ser Pro Glu Lys Arg Glu Glu Ala Trp Arg Phe Ile Ser Tyr Met Leu 
        115                 120                 125             


Val His Ala Gly Val Gln His Ile Leu Gly Asn Leu Cys Met Gln Leu 
    130                 135                 140                 


Val Leu Gly Ile Pro Leu Glu Met Val His Lys Gly Leu Arg Val Gly 
145                 150                 155                 160 


Leu Val Tyr Leu Ala Gly Val Ile Ala Gly Ser Leu Ala Ser Ser Ile 
                165                 170                 175     


Phe Asp Pro Leu Arg Tyr Leu Val Gly Ala Ser Gly Gly Val Tyr Ala 
            180                 185                 190         


Leu Met Gly Gly Tyr Phe Met Asn Val Leu Val Asn Phe Gln Glu Met 
        195                 200                 205             


Ile Pro Ala Phe Gly Ile Phe Arg Leu Leu Ile Ile Ile Leu Ile Ile 
    210                 215                 220                 


Val Leu Asp Met Gly Phe Ala Leu Tyr Arg Arg Phe Phe Val Pro Glu 
225                 230                 235                 240 


Asp Gly Ser Pro Val Ser Phe Ala Ala His Ile Ala Gly Gly Phe Ala 
                245                 250                 255     


Gly Met Ser Ile Gly Tyr Thr Val Phe Ser Cys Phe Asp Lys Ala Leu 
            260                 265                 270         


Leu Lys Asp Pro Arg Phe Trp Ile Ala Ile Ala Ala Tyr Leu Ala Cys 
        275                 280                 285             


Val Leu Phe Ala Val Phe Phe Asn Ile Phe Leu Ser Pro Ala Asn 
    290                 295                 300             


<210>  4
<211>  60
<212>  PRT
<213>  Mus musculus

<400>  4

Glu Gly Lys Arg Gln Asn Trp His Arg Arg Ser Leu His His Cys Ser 
1               5                   10                  15      


Val His Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg Glu Leu Glu Leu 
            20                  25                  30          


Pro Ser Gln Glu Val Pro Ser Phe Gln Gly Thr Glu Ser Pro Lys Pro 
        35                  40                  45              


Cys Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
    50                  55                  60  


<210>  5
<211>  60
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Glu Gly Lys Arg Gln Asn Trp Gln Arg Arg Ser Leu His His Cys Ser 
1               5                   10                  15      


Val His Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg Glu Leu Glu Leu 
            20                  25                  30          


Pro Ser Gln Glu Val Pro Ser Phe Gln Gly Thr Glu Ser Pro Lys Pro 
        35                  40                  45              


Cys Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
    50                  55                  60  


<210>  6
<211>  60
<212>  PRT
<213>  Canis familiaris

<400>  6

Glu Ala Lys Arg Gln His Trp Gln Arg Arg Ser Leu His His Cys Ser 
1               5                   10                  15      


Val Arg Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg Asp Leu Glu Leu 
            20                  25                  30          


Pro Ser Gln Glu Val Pro Ser Phe Gln Gly Thr Glu Ser Pro Lys Pro 
        35                  40                  45              


Cys Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
    50                  55                  60  


<210>  7
<211>  56
<212>  PRT
<213>  Ailuropoda melanoleuca


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Glu Xaa Trp Gln Leu Arg Ser Leu His His Cys Ser Val Arg Tyr Gly 
1               5                   10                  15      


Arg Leu Lys Ala Ser Cys Gln Arg Asp Leu Glu Leu Pro Ser Gln Glu 
            20                  25                  30          


Ala Pro Ser Phe Gln Gly Thr Glu Ser Pro Lys Pro Cys Lys Met Pro 
        35                  40                  45              


Lys Ile Val Asp Pro Leu Ala Arg 
    50                  55      


<210>  8
<211>  60
<212>  PRT
<213>  Equus caballus

<400>  8

Glu Val Lys Arg Gln His Trp Gln Arg Arg Ser Leu His His Cys Ser 
1               5                   10                  15      


Val Arg Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg Asp Leu Glu Leu 
            20                  25                  30          


Pro Ser Gln Glu Val Pro Ser Phe Gln Gly Thr Glu Ser Pro Lys Pro 
        35                  40                  45              


Cys Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
    50                  55                  60  


<210>  9
<211>  60
<212>  PRT
<213>  Bos taurus

<400>  9

Glu Leu Lys Arg Gln His Trp Gln Arg Arg Ser Leu His His Cys Ser 
1               5                   10                  15      


Val Arg Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg Asp Leu Glu Leu 
            20                  25                  30          


Pro Ser Gln Glu Val Pro Ser Phe Gln Asp Thr Glu Ser Pro Lys Pro 
        35                  40                  45              


Cys Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
    50                  55                  60  


<210>  10
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Gly Gln Arg Gln Gln Trp Gln Arg Arg Ser Leu His His Cys Ser 
1               5                   10                  15      


Met Arg Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg Asp Leu Glu Leu 
            20                  25                  30          


Pro Ser Gln Glu Ala Pro Ser Phe Gln Gly Thr Glu Ser Pro Lys Pro 
        35                  40                  45              


Cys Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
    50                  55                  60  


<210>  11
<211>  60
<212>  PRT
<213>  Pan troglodytes

<400>  11

Glu Gly Gln Arg Gln His Trp Gln Arg Arg Ser Leu His His Cys Ser 
1               5                   10                  15      


Val Arg Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg Asp Leu Glu Leu 
            20                  25                  30          


Pro Ser Gln Glu Ala Leu Ser Phe Gln Gly Thr Glu Ser Pro Lys Pro 
        35                  40                  45              


Cys Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
    50                  55                  60  


<210>  12
<211>  60
<212>  PRT
<213>  Macaca mulatta

<400>  12

Glu Gly Gln Arg Gln Gln Trp Gln Arg Arg Ser Leu His His Cys Ser 
1               5                   10                  15      


Val Arg Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg Asp Leu Glu Leu 
            20                  25                  30          


Pro Ser Gln Glu Ala Pro Ser Phe Gln Gly Thr Glu Ser Pro Lys Pro 
        35                  40                  45              


Cys Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
    50                  55                  60  


<210>  13
<211>  60
<212>  PRT
<213>  Callithrix jacchus

<400>  13

Glu Gly Gln Arg Gln Gln Trp Gln Arg Arg Ser Leu His His Cys Ser 
1               5                   10                  15      


Val Arg Tyr Gly Arg Leu Lys Ala Ser Cys Gln Arg Asp Leu Glu Leu 
            20                  25                  30          


Pro Ser Gln Glu Val Pro Ser Phe Gln Gly Thr Glu Ser Pro Lys Pro 
        35                  40                  45              


Cys Lys Leu Pro Lys Ile Val Asp Pro Leu Ala Arg 
    50                  55                  60  


<210>  14
<211>  59
<212>  PRT
<213>  Gallus gallus

<400>  14

Glu Gly Lys Arg Gln His Trp Gln Arg Arg Ser Leu Gln His Cys Ser 
1               5                   10                  15      


Met Arg Tyr Gly Lys Leu Lys Ala Ala Tyr Arg Asp Met Glu Leu Pro 
            20                  25                  30          


Ser Gln Glu Val Pro Ser Phe Gln Gly Thr Glu Ser Pro Lys Pro Ala 
        35                  40                  45              


Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
    50                  55                  


<210>  15
<211>  59
<212>  PRT
<213>  Taeniopygia guttata

<400>  15

Glu Gly Lys Arg Gln Gln Trp Gln Arg Lys Ser Leu Gln His Cys Ser 
1               5                   10                  15      


Met Arg Tyr Gly Lys Leu Lys Pro Ala Tyr Arg Asp Met Glu Leu Pro 
            20                  25                  30          


Ser Gln Glu Val Pro Ser Phe Gln Ala Thr Glu Ser Pro Lys Pro Thr 
        35                  40                  45              


Lys Met Pro Lys Ile Val Asp Pro Leu Ala Arg 
    50                  55                  


<210>  16
<211>  60
<212>  PRT
<213>  Xenopus tropicalis

<400>  16

Glu Gly Lys Arg Gln Gln Trp Gln Arg Lys Ser Leu His His Cys Ser 
1               5                   10                  15      


Leu Arg Tyr Gly Lys Leu Lys Pro Gln Tyr Gln Arg Asp Ile Glu Leu 
            20                  25                  30          


Pro Ser Gln Glu Thr Pro Ser Phe Gln Ala Thr Glu Ser Pro Ala Thr 
        35                  40                  45              


His Arg Leu Pro Lys Ile Val Asp Pro Leu Ala Arg 
    50                  55                  60  


<210>  17
<211>  56
<212>  PRT
<213>  Tetraodon nigroviridis

<400>  17

Glu Ser Gln Gln Gln Val Trp His Arg Lys Ser Leu Arg His Cys Ser 
1               5                   10                  15      


Gln Arg Tyr Gly Arg Leu Lys Ala Gln Tyr Arg Glu Pro Asp Thr Ala 
            20                  25                  30          


Ser Ser Leu Glu Pro Gly Leu Asp Ser Pro Gly Thr His Arg Leu Pro 
        35                  40                  45              


Lys Ile Val Asp Pro Leu Ala Arg 
    50                  55      


<210>  18
<211>  3603
<212>  DNA
<213>  Homo sapiens

<400>  18
cccgaggagc caccgcccag ccgctcgcag gcgccgcacg gagttgcgtc ccggggactt       60

ggggccgcag ggagctgtga gtacccagga agctgcaccg tgtggcctgg agctgtctat      120

ctgtccttcc agccacctgt ctgtccagcc acccttccac agactgaggc ttgacaccgg      180

agcatctgta cagagcaagg agaagacaag aacatgctct aaagcccttc acagcaagac      240

ccaggaagcc gcgggcaaac tcagactcga agccctcccg cctcctgccc acaatggcct      300

ctgctgacaa gaatggcggg agcgtgtcct ctgtgtccag cagccgcctg cagagccgga      360

agccacccaa cctctccatc accatcccgc cacccgagaa agagacccag gcccctggcg      420

agcaggacag catgctgcct gagggttttc agaataggag gctaaagaaa agccagccca      480

ggacctgggc tgcacacacc accgcctgcc ctccctcctt cctccccaag aggaagaacc      540

cagcctactt gaagagcgtc agcctccagg agccacgcag ccgatggcag gagagttcag      600

agaagcgccc tggcttccgc cgccaggcct cactgtccca gagcatccgc aagggcgcag      660

cccagtggtt tggagtcagc ggcgactggg aggggcagcg gcagcagtgg cagcgccgca      720

gcctgcacca ctgcagcatg cgctacggcc gcctgaaggc ctcgtgccag cgtgacctgg      780

agctccccag ccaggaggca ccgtccttcc agggcactga gtccccaaag ccctgcaaga      840

tgcccaagat tgtggatccg ctggcccggg gccgggcctt ccgccacccg gaggagatgg      900

acaggcccca cgccccgcac ccaccgctga cccccggagt cctgtccctc acctccttca      960

ccagtgtccg ttctggctac tcccacctgc cacgccgcaa gagaatgtct gtggcccaca     1020

tgagcttgca agctgccgct gccctcctca aggggcgctc ggtgctggat gccaccggac     1080

agcggtgccg ggtggtcaag cgcagctttg ccttcccgag cttcctggag gaggatgtgg     1140

tcgatggggc agacacgttt gactcctcct tttttagtaa ggaagaaatg agctccatgc     1200

ctgatgatgt ctttgagtcc cccccactct ctgccagcta cttccgaggg atcccacact     1260

cagcctcccc tgtctccccc gatggggtgc aaatccctct gaaggagtat ggccgagccc     1320

cagtccccgg gccccggcgc ggcaagcgca tcgcctccaa ggtgaagcac tttgcctttg     1380

atcggaagaa gcggcactac ggcctcggcg tggtgggcaa ctggctgaac cgcagctacc     1440

gccgcagcat cagcagcact gtgcagcggc agctggagag cttcgacagc caccggccct     1500

acttcaccta ctggctgacc ttcgtccatg tcatcatcac gctgctggtg atttgcacgt     1560

atggcatcgc acccgtgggc tttgcccagc acgtcaccac ccagctggtg ctgcggaaca     1620

aaggtgtgta cgagagcgtg aagtacatcc agcaggagaa cttctgggtt ggccccagct     1680

cgattgacct gatccacctg ggggccaagt tctcaccctg catccggaag gacgggcaga     1740

tcgagcagct ggtgctgcgc gagcgagacc tggagcggga ctcaggctgc tgtgtccaga     1800

atgaccactc cggatgcatc cagacccagc ggaaggactg ctcggagact ttggccactt     1860

ttgtcaagtg gcaggatgac actgggcccc ccatggacaa gtctgatctg ggccagaagc     1920

ggacttcggg ggctgtctgc caccaggacc ccaggacctg cgaggagcca gcctccagcg     1980

gtgcccacat ctggcccgat gacatcacta agtggccgat ctgcacagag caggccagga     2040

gcaaccacac aggcttcctg cacatggact gcgagatcaa gggccgcccc tgctgcatcg     2100

gcaccaaggg cagctgtgag atcaccaccc gggaatactg tgagttcatg cacggctatt     2160

tccatgagga agcaacactc tgctcccagg tgcactgctt ggacaaggtg tgtgggctgc     2220

tgcccttcct caaccctgag gtcccagatc agttctacag gctctggctg tctctcttcc     2280

tacatgctgg cgtggtgcac tgcctcgtgt ctgtggtctt tcaaatgacc atcctgaggg     2340

acctggagaa gctggccggc tggcaccgta tcgccatcat cttcatcctc agtggcatca     2400

caggcaacct cgccagtgcc atctttctcc cataccgggc agaggtgggc ccggccggct     2460

cacagttcgg cctcctcgcc tgcctcttcg tggagctctt ccagagctgg ccgctgctgg     2520

agaggccctg gaaggccttc ctcaacctct cggccatcgt gctcttcctg ttcatctgtg     2580

gcctcctgcc ctggatcgac aacatcgccc acatcttcgg cttcctcagt ggcctgctgc     2640

tggccttcgc cttcctgccc tacatcacct tcggcaccag cgacaagtac cgcaagcggg     2700

cactcatcct ggtgtcactg ctggcctttg ccggcctctt cgccgccctc gtgctgtggc     2760

tgtacatcta ccccattaac tggccctgga tcgagcacct cacctgcttc cccttcacca     2820

gccgcttctg cgagaagtat gagctggacc aggtgctgca ctgaccgctg ggccacacgg     2880

ctgcccctca gccctgctgg aacagggtct gcctgcgagg gctgccctct gcagagcgct     2940

ctctgtgtgc cagagagcca gagacccaag acagggcccg ggctctggac ctgggtgccc     3000

ccctgccagg cgaggctgac tccgcgtgag atggttggtt aaggcggggt ttttctgggg     3060

cgtgaggcct gtgagatcct gacccaagct caggcacacc caaggcacct gcctctctga     3120

gtcttgggtc tcagttccta atatcccgct ccttgctgag accatctcct ggggcagggt     3180

ccttttcttc ccaggtcctc agcgctgcct ctgctggtgc cttctccccc actactactg     3240

gagcgtgccc ttgctgggga cgtggctgtg ccctcagttg cccccagggc tgggtgccca     3300

ccatgcccct tcctctttct cctcctacct ctgccctgtg agcccatcca taaggctctc     3360

agatgggaca ttgtgggaaa ggctttggcc atggtctggg ggcagagaac aaggggggag     3420

acacaagtag acctcaggta gaacgacact gggcggagcc accccagggc ctgctcccag     3480

ggagtgctcg aggcgcatca ggcccgtttt ttaccagttt atatcacggt cttcattttt     3540

aaaagtaacg ctaactttgt acggacgatg tctcatggat taaataatat tctttatggc     3600

agt                                                                   3603


<210>  19
<211>  2571
<212>  DNA
<213>  Homo sapiens

<400>  19
atggcctctg ctgacaagaa tggcgggagc gtgtcctctg tgtccagcag ccgcctgcag       60

agccggaagc cacccaacct ctccatcacc atcccgccac ccgagaaaga gacccaggcc      120

cctggcgagc aggacagcat gctgcctgag ggttttcaga ataggaggct aaagaaaagc      180

cagcccagga cctgggctgc acacaccacc gcctgccctc cctccttcct ccccaagagg      240

aagaacccag cctacttgaa gagcgtcagc ctccaggagc cacgcagccg atggcaggag      300

agttcagaga agcgccctgg cttccgccgc caggcctcac tgtcccagag catccgcaag      360

ggcgcagccc agtggtttgg agtcagcggc gactgggagg ggcagcggca gcagtggcag      420

cgccgcagcc tgcaccactg cagcatgcgc tacggccgcc tgaaggcctc gtgccagcgt      480

gacctggagc tccccagcca ggaggcaccg tccttccagg gcactgagtc cccaaagccc      540

tgcaagatgc ccaagattgt ggatccgctg gcccggggcc gggccttccg ccacccggag      600

gagatggaca ggccccacgc cccgcaccca ccgctgaccc ccggagtcct gtccctcacc      660

tccttcacca gtgtccgttc tggctactcc cacctgccac gccgcaagag aatgtctgtg      720

gcccacatga gcttgcaagc tgccgctgcc ctcctcaagg ggcgctcggt gctggatgcc      780

accggacagc ggtgccgggt ggtcaagcgc agctttgcct tcccgagctt cctggaggag      840

gatgtggtcg atggggcaga cacgtttgac tcctcctttt ttagtaagga agaaatgagc      900

tccatgcctg atgatgtctt tgagtccccc ccactctctg ccagctactt ccgagggatc      960

ccacactcag cctcccctgt ctcccccgat ggggtgcaaa tccctctgaa ggagtatggc     1020

cgagccccag tccccgggcc ccggcgcggc aagcgcatcg cctccaaggt gaagcacttt     1080

gcctttgatc ggaagaagcg gcactacggc ctcggcgtgg tgggcaactg gctgaaccgc     1140

agctaccgcc gcagcatcag cagcactgtg cagcggcagc tggagagctt cgacagccac     1200

cggccctact tcacctactg gctgaccttc gtccatgtca tcatcacgct gctggtgatt     1260

tgcacgtatg gcatcgcacc cgtgggcttt gcccagcacg tcaccaccca gctggtgctg     1320

cggaacaaag gtgtgtacga gagcgtgaag tacatccagc aggagaactt ctgggttggc     1380

cccagctcga ttgacctgat ccacctgggg gccaagttct caccctgcat ccggaaggac     1440

gggcagatcg agcagctggt gctgcgcgag cgagacctgg agcgggactc aggctgctgt     1500

gtccagaatg accactccgg atgcatccag acccagcgga aggactgctc ggagactttg     1560

gccacttttg tcaagtggca ggatgacact gggcccccca tggacaagtc tgatctgggc     1620

cagaagcgga cttcgggggc tgtctgccac caggacccca ggacctgcga ggagccagcc     1680

tccagcggtg cccacatctg gcccgatgac atcactaagt ggccgatctg cacagagcag     1740

gccaggagca accacacagg cttcctgcac atggactgcg agatcaaggg ccgcccctgc     1800

tgcatcggca ccaagggcag ctgtgagatc accacccggg aatactgtga gttcatgcac     1860

ggctatttcc atgaggaagc aacactctgc tcccaggtgc actgcttgga caaggtgtgt     1920

gggctgctgc ccttcctcaa ccctgaggtc ccagatcagt tctacaggct ctggctgtct     1980

ctcttcctac atgctggcgt ggtgcactgc ctcgtgtctg tggtctttca aatgaccatc     2040

ctgagggacc tggagaagct ggccggctgg caccgtatcg ccatcatctt catcctcagt     2100

ggcatcacag gcaacctcgc cagtgccatc tttctcccat accgggcaga ggtgggcccg     2160

gccggctcac agttcggcct cctcgcctgc ctcttcgtgg agctcttcca gagctggccg     2220

ctgctggaga ggccctggaa ggccttcctc aacctctcgg ccatcgtgct cttcctgttc     2280

atctgtggcc tcctgccctg gatcgacaac atcgcccaca tcttcggctt cctcagtggc     2340

ctgctgctgg ccttcgcctt cctgccctac atcaccttcg gcaccagcga caagtaccgc     2400

aagcgggcac tcatcctggt gtcactgctg gcctttgccg gcctcttcgc cgccctcgtg     2460

ctgtggctgt acatctaccc cattaactgg ccctggatcg agcacctcac ctgcttcccc     2520

ttcaccagcc gcttctgcga gaagtatgag ctggaccagg tgctgcactg a              2571


<210>  20
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  20

Cys Thr Cys Cys Cys Thr Thr Cys Cys Ala Gly Ala Asn Thr Gly Thr 
1               5                   10                  15      


Gly Gly Ala Thr Cys Cys Gly Cys Thr Gly Gly Cys Cys Cys Gly Gly 
            20                  25                  30          


Gly 
    


<210>  21
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  21

Cys Thr Cys Cys Cys Thr Thr Cys Cys Ala Gly Ala Thr Thr Gly Thr 
1               5                   10                  15      


Gly Gly Ala Thr Cys Asn Gly Cys Thr Gly Gly Cys Cys Cys Gly Gly 
            20                  25                  30          


Gly 
    


<210>  22
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  22

Thr Cys Cys Cys Thr Thr Cys Cys Ala Gly Ala Thr Thr Gly Thr Gly 
1               5                   10                  15      


Gly Ala Thr Cys Asn Gly Cys Thr Gly Gly Cys Cys Cys Gly Gly Gly 
            20                  25                  30          


<210>  23
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  23

Cys Thr Cys Cys Cys Thr Thr Cys Cys Ala Asn Ala Thr Thr Gly Thr 
1               5                   10                  15      


Gly Asn Ala Thr Cys Cys Asn Asn Thr Gly Gly Cys Cys Cys Gly Gly 
            20                  25                  30          


Gly 
    


<210>  24
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  24

Cys Cys Gly Cys Cys Cys Cys Cys Cys Thr Cys Cys Cys Thr Thr Cys 
1               5                   10                  15      


Cys Ala Gly Ala Thr Thr Gly Thr Gly Gly Ala Thr Cys Cys Gly Cys 
            20                  25                  30          


Thr Gly Gly Cys Cys Cys Gly 
        35                  


<210>  25
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  25

Cys Cys Gly Cys Cys Cys Cys Cys Cys Thr Cys Cys Cys Thr Thr Cys 
1               5                   10                  15      


Cys Ala Gly Ala Asn Thr Gly Thr Gly Gly Ala Thr Cys Cys Gly Cys 
            20                  25                  30          


Thr Gly Gly Cys Cys Cys Gly 
        35                  


<210>  26
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  26

Thr Ala Cys Cys Asn Cys Cys Cys Cys Cys Asn Thr Cys Cys Asn Thr 
1               5                   10                  15      


Thr Cys Cys Ala Asn Ala Thr Thr Gly Asn Gly Gly Asn Thr Cys Cys 
            20                  25                  30          


Asn Asn Asn Gly Gly Cys Cys Cys Gly Gly Gly 
        35                  40              


<210>  27
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  27

Cys Cys Asn Cys Cys Cys Cys Cys Cys Thr Cys Cys Cys Thr Thr Cys 
1               5                   10                  15      


Cys Ala Gly Ala Asn Thr Gly Thr Gly Gly Ala Thr Cys Cys Gly Cys 
            20                  25                  30          


Thr Gly Gly Cys Cys Cys Gly 
        35                  


<210>  28
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  28

Cys Cys Gly Cys Cys Cys Cys Cys Cys Thr Cys Cys Cys Thr Thr Cys 
1               5                   10                  15      


Cys Ala Gly Ala Asn Thr Gly Thr Gly Gly Ala Thr Cys Cys Gly Cys 
            20                  25                  30          


Thr Gly Gly Cys Cys Cys Gly 
        35                  


