                         SEQUENCE LISTING

<110>  Eli Lilly and Company
 
<120>  Variants of Human GDNF

<130>  X19073

<150>  61/474024
<151>  2011-04-11

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  2
<211>  633
<212>  DNA
<213>  Homo sapiens

<400>  2
atgaagctgt gggacgtggt ggccgtgtgc ctggtgctgc tgcacaccgc cagcgctttc       60

ccactgccag ccggcaagag acccccagag gccccagccg aggacagaag cctgggcagg      120

cggagggccc cattcgccct gagcagcgac agcaacatgc cagaggacta ccccgaccag      180

ttcgacgacg tcatggactt catccaggcc accatcaaga ggctgaagag gtcacccgac      240

aagcagatgg ccgtgctgcc caggcgggag aggaacaggc aggccgccgc cgccaaccca      300

gagaattcca ggggcaaggg cagaaggggt caacggggca agaacagggg ctgcgtgctg      360

accgccatcc acctgaacgt gaccgacctg ggcctgggct acgagaccaa ggaggagctg      420

atcttcaggt actgcagcgg cagctgcgac gccgccgaga ccacctacga caagatcctg      480

aagaacctga gcaggaacag gcggctggtc tccgacaagg tgggccaggc ctgctgcagg      540

cccatcgcct tcgacgacga cctgagcttc ctggacgaca acctggtgta ccacatcctg      600

aggaagcaca gcgccaagag atgcggctgc atc                                   633


<210>  3
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Pro Asp Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg 
1               5                   10                  15      


Gln Ala Ala Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg 
            20                  25                  30          


Gly Gln Arg Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu 
        35                  40                  45              


Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile 
    50                  55                  60                  


Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp 
65                  70                  75                  80  


Lys Ile Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys 
                85                  90                  95      


Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser 
            100                 105                 110         


Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala 
        115                 120                 125             


Lys Arg Cys Gly Cys Ile 
    130                 


<210>  4
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala 
            


<210>  5
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro Ala Glu Asp 
1               5                   10                  15      


Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser Ser Asp Ser 
            20                  25                  30          


Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val Met Asp Phe 
        35                  40                  45              


Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg 
    50                  55              


<210>  6
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6
tatacatatg cgtggacaac gtggtaaaaa ccgtggttgt gtgctg                      46


<210>  7
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
ggtgctcgag ttattaaatg cagccgcaac gtttcgcgct                             40


<210>  8
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Gly Gln Arg Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His 
1               5                   10                  15      


Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu 
            20                  25                  30          


Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr 
        35                  40                  45              


Asp Lys Ile Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp 
    50                  55                  60                  


Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu 
65                  70                  75                  80  


Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser 
                85                  90                  95      


Ala Lys Arg Cys Gly Cys Ile 
            100             


<210>  9
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Arg Gly Gln Arg Gly Lys Gln Arg Gly Cys Val Leu Thr Ala Ile His 
1               5                   10                  15      


Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu 
            20                  25                  30          


Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr 
        35                  40                  45              


Asp Lys Ile Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Glu 
    50                  55                  60                  


Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu 
65                  70                  75                  80  


Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser 
                85                  90                  95      


Ala Lys Arg Cys Gly Cys Ile 
            100             


<210>  10
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
aggggtcaac ggggcaagca gaggggctgc gtgctgaccg ccatccacct gaacgtgacc       60

gacctgggcc tgggctacga gaccaaggag gagctgatct tcaggtactg cagcggcagc      120

tgcgacgccg ccgagaccac ctacgacaag atcctgaaga acctgagcag gaacaggcgg      180

ctggtctccg agaaggtggg ccaggcctgc tgcaggccca tcgccttcga cgacgacctg      240

agcttcctgg acgacaacct ggtgtaccac atcctgagga agcacagcgc caagagatgc      300

ggctgcatc                                                              309


<210>  11
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Gln Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Glu Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  12
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Arg Gly Gln Arg Gly Lys Gln Arg Gly Cys Val Leu Thr Ala Ile His 
1               5                   10                  15      


Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu 
            20                  25                  30          


Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr 
        35                  40                  45              


Asp Lys Ile Leu Ala Asn Leu Ser Lys Asn Lys Arg Leu Val Ser Glu 
    50                  55                  60                  


Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu 
65                  70                  75                  80  


Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser 
                85                  90                  95      


Ala Lys Arg Cys Gly Cys Ile 
            100             


<210>  13
<211>  633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
atgaagctgt gggacgtggt ggccgtgtgc ctggtgctgc tgcacaccgc cagcgctttc       60

ccactgccag ccggcaagag acccccagag gccccagccg aggacagaag cctgggcagg      120

cggagggccc cattcgccct gagcagcgac agcaacatgc cagaggacta ccccgaccag      180

ttcgacgacg tcatggactt catccaggcc accatcaaga ggctgaagag gtcacccgac      240

aagcagatgg ccgtgctgcc caggcgggag aggaacaggc aggccgccgc cgccaaccca      300

gagaattcca ggggcaaggg cagaaggggt caacggggca agcagagggg ctgcgtgctg      360

accgccatcc acctgaacgt gaccgacctg ggcctgggct acgagaccaa ggaggagctg      420

atcttcaggt actgcagcgg cagctgcgac gccgccgaga ccacctacga caagatcctg      480

gccaacctga gcaagaacaa gcggctggtc tccgagaagg tgggccaggc ctgctgcagg      540

cccatcgcct tcgacgacga cctgagcttc ctggacgaca acctggtgta ccacatcctg      600

aggaagcaca gcgccaagag atgcggctgc atc                                   633


<210>  14
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Gln Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Ala Asn Leu Ser Lys Asn Lys Arg Leu Val Ser Glu Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  15
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Arg Gly Gln Arg Gly Lys Gln Arg Gly Cys Val Leu Thr Ala Ile His 
1               5                   10                  15      


Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu 
            20                  25                  30          


Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr 
        35                  40                  45              


Asp Lys Ile Leu Ala Asn Leu Ser Lys Asn Lys Arg Leu Val Ser Glu 
    50                  55                  60                  


Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu 
65                  70                  75                  80  


Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg Glu His Ser 
                85                  90                  95      


Ala Lys Glu Cys Gly Cys Ile 
            100             


<210>  16
<211>  633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
atgaagctgt gggacgtggt ggccgtgtgc ctggtgctgc tgcacaccgc cagcgctttc       60

ccactgccag ccggcaagag acccccagag gccccagccg aggacagaag cctgggcagg      120

cggagggccc cattcgccct gagcagcgac agcaacatgc cagaggacta ccccgaccag      180

ttcgacgacg tcatggactt catccaggcc accatcaaga ggctgaagag gtcacccgac      240

aagcagatgg ccgtgctgcc caggcgggag aggaacaggc aggccgccgc cgccaaccca      300

gagaattcca ggggcaaggg cagaaggggt caacggggca agcagagggg ctgcgtgctg      360

accgccatcc acctgaacgt gaccgacctg ggcctgggct acgagaccaa ggaggagctg      420

atcttcaggt actgcagcgg cagctgcgac gccgccgaga ccacctacga caagatcctg      480

gccaacctga gcaagaacaa gcggctggtc tccgagaagg tgggccaggc ctgctgcagg      540

cccatcgcct tcgacgacga cctgagcttc ctggacgaca acctggtgta ccacatcctg      600

agggagcaca gcgccaagga gtgcggctgc atc                                   633


<210>  17
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Gln Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Ala Asn Leu Ser Lys Asn Lys Arg Leu Val Ser Glu Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Glu His Ser Ala Lys Glu Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  18
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  18
atgaagctgt gggacgtggt ggccgtgtgc ctggtgctgc tgcacaccgc cagcgct          57


<210>  19
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19
atgaagctgt gggacgtggt ggccgtgtgc ctggtgctgc tgcacaccgc cagcgctagg       60

ggtcaacggg gcaagcagag gggctgcgtg ctgaccgcca tccacctgaa cgtgaccgac      120

ctgggcctgg gctacgagac caaggaggag ctgatcttca ggtactgcag cggcagctgc      180

gacgccgccg agaccaccta cgacaagatc ctgaagaacc tgagcaggaa caggcggctg      240

gtctccgaga aggtgggcca ggcctgctgc aggcccatcg ccttcgacga cgacctgagc      300

ttcctggacg acaacctggt gtaccacatc ctgaggaagc acagcgccaa gagatgcggc      360

tgcatc                                                                 366


<210>  20
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Arg Gly Gln Arg Gly Lys Gln Arg Gly Cys Val Leu Thr 
            20                  25                  30          


Ala Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys 
        35                  40                  45              


Glu Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu 
    50                  55                  60                  


Thr Thr Tyr Asp Lys Ile Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu 
65                  70                  75                  80  


Val Ser Glu Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp 
                85                  90                  95      


Asp Asp Leu Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg 
            100                 105                 110         


Lys His Ser Ala Lys Arg Cys Gly Cys Ile 
        115                 120         


<210>  21
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21
atgaagctgt gggacgtggt ggccgtgtgc ctggtgctgc tgcacaccgc cagcgctagg       60

ggtcaacggg gcaagcagag gggctgcgtg ctgaccgcca tccacctgaa cgtgaccgac      120

ctgggcctgg gctacgagac caaggaggag ctgatcttca ggtactgcag cggcagctgc      180

gacgccgccg agaccaccta cgacaagatc ctggccaacc tgagcaagaa caagcggctg      240

gtctccgaga aggtgggcca ggcctgctgc aggcccatcg ccttcgacga cgacctgagc      300

ttcctggacg acaacctggt gtaccacatc ctgaggaagc acagcgccaa gagatgcggc      360

tgcatc                                                                 366


<210>  22
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Arg Gly Gln Arg Gly Lys Gln Arg Gly Cys Val Leu Thr 
            20                  25                  30          


Ala Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys 
        35                  40                  45              


Glu Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu 
    50                  55                  60                  


Thr Thr Tyr Asp Lys Ile Leu Ala Asn Leu Ser Lys Asn Lys Arg Leu 
65                  70                  75                  80  


Val Ser Glu Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp 
                85                  90                  95      


Asp Asp Leu Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg 
            100                 105                 110         


Lys His Ser Ala Lys Arg Cys Gly Cys Ile 
        115                 120         


<210>  23
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa at position 53 is Lys or Ala

<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Xaa at position 57 is Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  Xaa at position 59 is Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa at position 94 is Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  Xaa at position 99 is Arg or Glu

<400>  23

Arg Gly Gln Arg Gly Lys Gln Arg Gly Cys Val Leu Thr Ala Ile His 
1               5                   10                  15      


Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu 
            20                  25                  30          


Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr 
        35                  40                  45              


Asp Lys Ile Leu Xaa Asn Leu Ser Xaa Asn Xaa Arg Leu Val Ser Glu 
    50                  55                  60                  


Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu 
65                  70                  75                  80  


Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg Xaa His Ser 
                85                  90                  95      


Ala Lys Xaa Cys Gly Cys Ile 
            100             


<210>  24
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa at position 72 is Lys or Ala

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa at position 76 is arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  Xaa at position 78 is Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  Xaa at position 113 is Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (118)..(118)
<223>  Xaa at position 118 is Arg or Glu

<400>  24

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Arg Gly Gln Arg Gly Lys Gln Arg Gly Cys Val Leu Thr 
            20                  25                  30          


Ala Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys 
        35                  40                  45              


Glu Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu 
    50                  55                  60                  


Thr Thr Tyr Asp Lys Ile Leu Xaa Asn Leu Ser Xaa Asn Xaa Arg Leu 
65                  70                  75                  80  


Val Ser Glu Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp 
                85                  90                  95      


Asp Asp Leu Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg 
            100                 105                 110         


Xaa His Ser Ala Lys Xaa Cys Gly Cys Ile 
        115                 120         


<210>  25
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  25

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  26
<211>  60
<212>  DNA
<213>  Mus musculus

<400>  26
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg atctaccggt       60


<210>  27
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg atctaccggt       60

aggggtcaac ggggcaagca gaggggctgc gtgctgaccg ccatccacct gaacgtgacc      120

gacctgggcc tgggctacga gaccaaggag gagctgatct tcaggtactg cagcggcagc      180

tgcgacgccg ccgagaccac ctacgacaag atcctgaaga acctgagcag gaacaggcgg      240

ctggtctccg agaaggtggg ccaggcctgc tgcaggccca tcgccttcga cgacgacctg      300

agcttcctgg acgacaacct ggtgtaccac atcctgagga agcacagcgc caagagatgc      360

ggctgcatc                                                              369


<210>  28
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Arg Gly Gln Arg Gly Lys Gln Arg Gly Cys Val Leu 
            20                  25                  30          


Thr Ala Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr 
        35                  40                  45              


Lys Glu Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala 
    50                  55                  60                  


Glu Thr Thr Tyr Asp Lys Ile Leu Lys Asn Leu Ser Arg Asn Arg Arg 
65                  70                  75                  80  


Leu Val Ser Glu Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe 
                85                  90                  95      


Asp Asp Asp Leu Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu 
            100                 105                 110         


Arg Lys His Ser Ala Lys Arg Cys Gly Cys Ile 
        115                 120             


<210>  29
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg atctaccggt       60

aggggtcaac ggggcaagca gaggggctgc gtgctgaccg ccatccacct gaacgtgacc      120

gacctgggcc tgggctacga gaccaaggag gagctgatct tcaggtactg cagcggcagc      180

tgcgacgccg ccgagaccac ctacgacaag atcctggcca acctgagcaa gaacaagcgg      240

ctggtctccg agaaggtggg ccaggcctgc tgcaggccca tcgccttcga cgacgacctg      300

agcttcctgg acgacaacct ggtgtaccac atcctgagga agcacagcgc caagagatgc      360

ggctgcatc                                                              369


<210>  30
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Arg Gly Gln Arg Gly Lys Gln Arg Gly Cys Val Leu 
            20                  25                  30          


Thr Ala Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr 
        35                  40                  45              


Lys Glu Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala 
    50                  55                  60                  


Glu Thr Thr Tyr Asp Lys Ile Leu Ala Asn Leu Ser Lys Asn Lys Arg 
65                  70                  75                  80  


Leu Val Ser Glu Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe 
                85                  90                  95      


Asp Asp Asp Leu Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu 
            100                 105                 110         


Arg Lys His Ser Ala Lys Arg Cys Gly Cys Ile 
        115                 120             


<210>  31
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  Xaa at position 73 is Lys or Ala

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  Xaa at position 77 is Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Xaa at position 79 is Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  Xaa at position 114 is Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  Xaa at position 119 is Arg or Glu

<400>  31

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Arg Gly Gln Arg Gly Lys Gln Arg Gly Cys Val Leu 
            20                  25                  30          


Thr Ala Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr 
        35                  40                  45              


Lys Glu Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala 
    50                  55                  60                  


Glu Thr Thr Tyr Asp Lys Ile Leu Xaa Asn Leu Ser Xaa Asn Xaa Arg 
65                  70                  75                  80  


Leu Val Ser Glu Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe 
                85                  90                  95      


Asp Asp Asp Leu Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu 
            100                 105                 110         


Arg Xaa His Ser Ala Lys Xaa Cys Gly Cys Ile 
        115                 120             


<210>  32
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala 
            20                  25      


<210>  33
<211>  78
<212>  DNA
<213>  Homo sapiens

<400>  33
atggctaccg gcagcaggac ctctctgctg ctggccttcg gcctgctgtg cctgccctgg       60

ctgcaggaag gcagcgcc                                                     78


<210>  34
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34
atggctaccg gcagcaggac ctctctgctg ctggccttcg gcctgctgtg cctgccctgg       60

ctgcaggaag gcagcgccag gggtcaacgg ggcaagcaga ggggctgcgt gctgaccgcc      120

atccacctga acgtgaccga cctgggcctg ggctacgaga ccaaggagga gctgatcttc      180

aggtactgca gcggcagctg cgacgccgcc gagaccacct acgacaagat cctgaagaac      240

ctgagcagga acaggcggct ggtctccgag aaggtgggcc aggcctgctg caggcccatc      300

gccttcgacg acgacctgag cttcctggac gacaacctgg tgtaccacat cctgaggaag      360

cacagcgcca agagatgcgg ctgcatc                                          387


<210>  35
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Arg Gly Gln Arg Gly Lys 
            20                  25                  30          


Gln Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr Asp Leu 
        35                  40                  45              


Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr Cys Ser 
    50                  55                  60                  


Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu Lys Asn 
65                  70                  75                  80  


Leu Ser Arg Asn Arg Arg Leu Val Ser Glu Lys Val Gly Gln Ala Cys 
                85                  90                  95      


Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp Asp Asn 
            100                 105                 110         


Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys Gly Cys 
        115                 120                 125             


Ile 
    


<210>  36
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36
atggctaccg gcagcaggac ctctctgctg ctggccttcg gcctgctgtg cctgccctgg       60

ctgcaggaag gcagcgccag gggtcaacgg ggcaagcaga ggggctgcgt gctgaccgcc      120

atccacctga acgtgaccga cctgggcctg ggctacgaga ccaaggagga gctgatcttc      180

aggtactgca gcggcagctg cgacgccgcc gagaccacct acgacaagat cctggccaac      240

ctgagcaaga acaagcggct ggtctccgag aaggtgggcc aggcctgctg caggcccatc      300

gccttcgacg acgacctgag cttcctggac gacaacctgg tgtaccacat cctgaggaag      360

cacagcgcca agagatgcgg ctgcatc                                          387


<210>  37
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Arg Gly Gln Arg Gly Lys 
            20                  25                  30          


Gln Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr Asp Leu 
        35                  40                  45              


Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr Cys Ser 
    50                  55                  60                  


Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu Ala Asn 
65                  70                  75                  80  


Leu Ser Lys Asn Lys Arg Leu Val Ser Glu Lys Val Gly Gln Ala Cys 
                85                  90                  95      


Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp Asp Asn 
            100                 105                 110         


Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys Gly Cys 
        115                 120                 125             


Ile 
    


<210>  38
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Xaa at position 79 is Lys or Ala

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  Xaa at position 83 is Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  Xaa at position 85 is Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (120)..(120)
<223>  Xaa at position 120 is Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (125)..(125)
<223>  Xaa at position 125 is Arg or Glu

<400>  38

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Arg Gly Gln Arg Gly Lys 
            20                  25                  30          


Gln Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr Asp Leu 
        35                  40                  45              


Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr Cys Ser 
    50                  55                  60                  


Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu Xaa Asn 
65                  70                  75                  80  


Leu Ser Xaa Asn Xaa Arg Leu Val Ser Glu Lys Val Gly Gln Ala Cys 
                85                  90                  95      


Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp Asp Asn 
            100                 105                 110         


Leu Val Tyr His Ile Leu Arg Xaa His Ser Ala Lys Xaa Cys Gly Cys 
        115                 120                 125             


Ile 
    


<210>  39
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39
tatacatatg cgtggacaac gtggtaaaca acgtggttgt gtgctg                      46


<210>  40
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40
ggtgctcgag ttattaaatg cagccgcaac gtttcgcgct                             40


<210>  41
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41
gtctggtgag cgagaaagtg ggtcag                                            26


<210>  42
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42
ctgacccact ttctcgctca ccagac                                            26


<210>  43
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43
cctatgataa aatcctggca aacctgagca agaacaaacg tctggtgagc gagaaag          57


<210>  44
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44
ctttctcgct caccagacgt ttgttcttgc tcaggtttgc caggatttta tcatagg          57


