                         SEQUENCE LISTING

<110>  Universitt Leipzig
 
<120>  Polymutant tau protein variants and their use for recapitulating 
       human tauopathies

<130>  Polymutant tau protein variants

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  383
<212>  PRT
<213>  homo sapiens

<400>  1

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu Ala 
        35                  40                  45              


Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
    50                  55                  60                  


Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
65                  70                  75                  80  


Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
                85                  90                  95      


Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
            100                 105                 110         


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
        115                 120                 125             


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
    130                 135                 140                 


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
145                 150                 155                 160 


Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
                165                 170                 175     


Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
            180                 185                 190         


Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu 
        195                 200                 205             


Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu 
    210                 215                 220                 


Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
225                 230                 235                 240 


His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp 
                245                 250                 255     


Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His 
            260                 265                 270         


Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
        275                 280                 285             


Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His 
    290                 295                 300                 


Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
305                 310                 315                 320 


Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr 
                325                 330                 335     


Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn 
            340                 345                 350         


Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala 
        355                 360                 365             


Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    370                 375                 380             


<210>  2
<211>  441
<212>  PRT
<213>  homo sapiens

<400>  2

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  3
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human tau having five mutations

<400>  3

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu Ala 
        35                  40                  45              


Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
    50                  55                  60                  


Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
65                  70                  75                  80  


Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
                85                  90                  95      


Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
            100                 105                 110         


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
        115                 120                 125             


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
    130                 135                 140                 


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
145                 150                 155                 160 


Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
                165                 170                 175     


Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
            180                 185                 190         


Pro Asp Leu Lys Asn Val Thr Ser Lys Ile Gly Ser Thr Glu Asn Leu 
        195                 200                 205             


Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Leu Asp 
    210                 215                 220                 


Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His 
225                 230                 235                 240 


Val Leu Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu 
                245                 250                 255     


Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys 
            260                 265                 270         


Pro Gly Gly Gly Gln Met Glu Val Lys Ser Glu Lys Leu Asp Phe Lys 
        275                 280                 285             


Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val 
    290                 295                 300                 


Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg 
305                 310                 315                 320 


Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys 
                325                 330                 335     


Ser Pro Val Val Ser Gly Asp Thr Ser Pro Trp His Leu Ser Asn Val 
            340                 345                 350         


Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr 
        355                 360                 365             


Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    370                 375                 380         


<210>  4
<211>  1152
<212>  DNA
<213>  Homo sapiens

<400>  4
atggctgagc cccgccagga gttcgaagtg atggaagatc acgctgggac gtacgggttg       60

ggggacagga aagatcaggg gggctacacc atgcaccaag accaagaggg tgacacggac      120

gctggcctga aagctgaaga agcaggcatt ggagacaccc ccagcctgga agacgaagct      180

gctggtcacg tgacccaagc tcgcatggtc agtaaaagca aagacgggac tggaagcgat      240

gacaaaaaag ccaagggggc tgatggtaaa acgaagatcg ccacaccgcg gggagcagcc      300

cctccaggcc agaagggcca ggccaacgcc accaggattc cagcaaaaac cccgcccgct      360

ccaaagacac cacccagctc tggtgaacct ccaaaatcag gggatcgcag cggctacagc      420

agccccggct ccccaggcac tcccggcagc cgctcccgca ccccgtccct tccaacccca      480

cccacccggg agcccaagaa ggtggcagtg gtccgtactc cacccaagtc gccgtcttcc      540

gccaagagcc gcctgcagac agcccccgtg cccatgccag acctgaagaa tgtcaagtcc      600

aagatcggct ccactgagaa cctgaagcac cagccgggag gcgggaaggt gcagataatt      660

aataagaagc tggatcttag caacgtccag tccaagtgtg gctcaaagga taatatcaaa      720

cacgtcccgg gaggcggcag tgtgcaaata gtctacaaac cagttgacct gagcaaggtg      780

acctccaagt gtggctcatt aggcaacatc catcataaac caggaggtgg ccaggtggaa      840

gtaaaatctg agaagcttga cttcaaggac agagtccagt cgaagattgg gtccctggac      900

aatatcaccc acgtccctgg cggaggaaat aaaaagattg aaacccacaa gctgaccttc      960

cgcgagaacg ccaaagccaa gacagaccac ggggcggaga tcgtgtacaa gtcgccagtg     1020

gtgtctgggg acacgtctcc acggcatctc agcaatgtct cctccaccgg cagcatcgac     1080

atggtagact cgccccagct cgccacgcta gctgacgagg tgtctgcctc cctggccaag     1140

cagggtttgt ga                                                         1152


<210>  5
<211>  1149
<212>  DNA
<213>  homo sapiens

<400>  5
atggctgagc cccgccagga gttcgaagtg atggaagatc acgctgggac gtacgggttg       60

ggggacagga aagatcaggg gggctacacc atgcaccaag accaagaggg tgacacggac      120

gctggcctga aagctgaaga agcaggcatt ggagacaccc ccagcctgga agacgaagct      180

gctggtcacg tgacccaagc tcgcatggtc agtaaaagca aagacgggac tggaagcgat      240

gacaaaaaag ccaagggggc tgatggtaaa acgaagatcg ccacaccgcg gggagcagcc      300

cctccaggcc agaagggcca ggccaacgcc accaggattc cagcaaaaac cccgcccgct      360

ccaaagacac cacccagctc tggtgaacct ccaaaatcag gggatcgcag cggctacagc      420

agccccggct ccccaggcac tcccggcagc cgctcccgca ccccgtccct tccaacccca      480

cccacccggg agcccaagaa ggtggcagtg gtccgtactc cacccaagtc gccgtcttcc      540

gccaagagcc gcctgcagac agcccccgtg cccatgccag acctgaagaa tgtcacgtcc      600

aagatcggct ccactgagaa cctgaagcac cagccgggag gcgggaaggt gcagataatt      660

aataagctgg atcttagcaa cgtccagtcc aagtgtggct caaaggataa tatcaaacac      720

gtcctgggag gcggcagtgt gcaaatagtc tacaaaccag ttgacctgag caaggtgacc      780

tccaagtgtg gctcattagg caacatccat cataaaccag gaggtggcca gatggaagta      840

aaatctgaga agcttgactt caaggacaga gtccagtcga agattgggtc cctggacaat      900

atcacccacg tccctggcgg aggaaataaa aagattgaaa cccacaagct gaccttccgc      960

gagaacgcca aagccaagac agaccacggg gcggagatcg tgtacaagtc gccagtggtg     1020

tctggggaca cgtctccatg gcatctcagc aatgtctcct ccaccggcag catcgacatg     1080

gtagactcgc cccagctcgc cacgctagct gacgaggtgt ctgcctccct ggccaagcag     1140

ggtttgtga                                                             1149


<210>  6
<211>  441
<212>  PRT
<213>  homo sapiens

<400>  6

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  7
<211>  1326
<212>  DNA
<213>  homo sapiens

<400>  7
atggctgagc cccgccagga gttcgaagtg atggaagatc acgctgggac gtacgggttg       60

ggggacagga aagatcaggg gggctacacc atgcaccaag accaagaggg tgacacggac      120

gctggcctga aagaatctcc cctgcagacc cccactgagg acggatctga ggaaccgggc      180

tctgaaacct ctgatgctaa gagcactcca acagcggaag atgtgacagc acccttagtg      240

gatgagggag ctcccggcaa gcaggctgcc gcgcagcccc acacggagat cccagaagga      300

accacagctg aagaagcagg cattggagac acccccagcc tggaagacga agctgctggt      360

cacgtgaccc aagctcgcat ggtcagtaaa agcaaagacg ggactggaag cgatgacaaa      420

aaagccaagg gggctgatgg taaaacgaag atcgccacac cgcggggagc agcccctcca      480

ggccagaagg gccaggccaa cgccaccagg attccagcaa aaaccccgcc cgctccaaag      540

acaccaccca gctctggtga acctccaaaa tcaggggatc gcagcggcta cagcagcccc      600

ggctccccag gcactcccgg cagccgctcc cgcaccccgt cccttccaac cccacccacc      660

cgggagccca agaaggtggc agtggtccgt actccaccca agtcgccgtc ttccgccaag      720

agccgcctgc agacagcccc cgtgcccatg ccagacctga agaatgtcaa gtccaagatc      780

ggctccactg agaacctgaa gcaccagccg ggaggcggga aggtgcagat aattaataag      840

aagctggatc ttagcaacgt ccagtccaag tgtggctcaa aggataatat caaacacgtc      900

ccgggaggcg gcagtgtgca aatagtctac aaaccagttg acctgagcaa ggtgacctcc      960

aagtgtggct cattaggcaa catccatcat aaaccaggag gtggccaggt ggaagtaaaa     1020

tctgagaagc ttgacttcaa ggacagagtc cagtcgaaga ttgggtccct ggacaatatc     1080

acccacgtcc ctggcggagg aaataaaaag attgaaaccc acaagctgac cttccgcgag     1140

aacgccaaag ccaagacaga ccacggggcg gagatcgtgt acaagtcgcc agtggtgtct     1200

ggggacacgt ctccacggca tctcagcaat gtctcctcca ccggcagcat cgacatggta     1260

gactcgcccc agctcgccac gctagctgac gaggtgtctg cctccctggc caagcagggt     1320

ttgtga                                                                1326


<210>  8
<211>  412
<212>  PRT
<213>  homo sapiens

<400>  8

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu Glu Ala Gly Ile Gly 
65                  70                  75                  80  


Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala 
                85                  90                  95      


Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys 
            100                 105                 110         


Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala 
        115                 120                 125             


Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala 
    130                 135                 140                 


Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro 
145                 150                 155                 160 


Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr 
                165                 170                 175     


Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg 
            180                 185                 190         


Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser 
        195                 200                 205             


Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu 
    210                 215                 220                 


Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln 
225                 230                 235                 240 


Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser 
                245                 250                 255     


Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro 
            260                 265                 270         


Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
        275                 280                 285             


Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
    290                 295                 300                 


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
305                 310                 315                 320 


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
                325                 330                 335     


Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn 
            340                 345                 350         


Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
        355                 360                 365             


Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser 
    370                 375                 380                 


Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala 
385                 390                 395                 400 


Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
                405                 410         


<210>  9
<211>  1239
<212>  DNA
<213>  homo sapiens

<400>  9
atggctgagc cccgccagga gttcgaagtg atggaagatc acgctgggac gtacgggttg       60

ggggacagga aagatcaggg gggctacacc atgcaccaag accaagaggg tgacacggac      120

gctggcctga aagaatctcc cctgcagacc cccactgagg acggatctga ggaaccgggc      180

tctgaaacct ctgatgctaa gagcactcca acagcggaag ctgaagaagc aggcattgga      240

gacaccccca gcctggaaga cgaagctgct ggtcacgtga cccaagctcg catggtcagt      300

aaaagcaaag acgggactgg aagcgatgac aaaaaagcca agggggctga tggtaaaacg      360

aagatcgcca caccgcgggg agcagcccct ccaggccaga agggccaggc caacgccacc      420

aggattccag caaaaacccc gcccgctcca aagacaccac ccagctctgg tgaacctcca      480

aaatcagggg atcgcagcgg ctacagcagc cccggctccc caggcactcc cggcagccgc      540

tcccgcaccc cgtcccttcc aaccccaccc acccgggagc ccaagaaggt ggcagtggtc      600

cgtactccac ccaagtcgcc gtcttccgcc aagagccgcc tgcagacagc ccccgtgccc      660

atgccagacc tgaagaatgt caagtccaag atcggctcca ctgagaacct gaagcaccag      720

ccgggaggcg ggaaggtgca gataattaat aagaagctgg atcttagcaa cgtccagtcc      780

aagtgtggct caaaggataa tatcaaacac gtcccgggag gcggcagtgt gcaaatagtc      840

tacaaaccag ttgacctgag caaggtgacc tccaagtgtg gctcattagg caacatccat      900

cataaaccag gaggtggcca ggtggaagta aaatctgaga agcttgactt caaggacaga      960

gtccagtcga agattgggtc cctggacaat atcacccacg tccctggcgg aggaaataaa     1020

aagattgaaa cccacaagct gaccttccgc gagaacgcca aagccaagac agaccacggg     1080

gcggagatcg tgtacaagtc gccagtggtg tctggggaca cgtctccacg gcatctcagc     1140

aatgtctcct ccaccggcag catcgacatg gtagactcgc cccagctcgc cacgctagct     1200

gacgaggtgt ctgcctccct ggccaagcag ggtttgtga                            1239


