                         SEQUENCE LISTING

<110>  Sanofi
 
<120>  Test systems and methods for identifying a compound altering DDR 
       activity

<130>  DE2011/081 WO PCT

<150>  EP 11305488.6
<151>  2011-04-26

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  3840
<212>  DNA
<213>  Homo sapiens

<400>  1
gtcttcccct cgtgggccct gagcgggact gcagccagcc ccctggggcg ccagctttgg       60

aggcccccga cagctgctct cgggagccgc ctcccgacac ccgagccccg ccggcgcctc      120

ccgctcccgg ctcccggctc ctggctccct ccgcctcccc cgcccctcgc cccgccgccg      180

aagaggcccc gctcccgggt cggacgcctg ggtctgccgg gaagagcgat gagaggtgtc      240

tgaaggtggc tattcactga gcgatggggt tggacttgaa ggaatgccaa gagatgctgc      300

ccccaccccc ttaggcccga gggatcagga gctatgggac cagaggccct gtcatcttta      360

ctgctgctgc tcttggtggc aagtggagat gctgacatga agggacattt tgatcctgcc      420

aagtgccgct atgccctggg catgcaggac cggaccatcc cagacagtga catctctgct      480

tccagctcct ggtcagattc cactgccgcc cgccacagca ggttggagag cagtgacggg      540

gatggggcct ggtgccccgc agggtcggtg tttcccaagg aggaggagta cttgcaggtg      600

gatctacaac gactgcacct ggtggctctg gtgggcaccc agggacggca tgccgggggc      660

ctgggcaagg agttctcccg gagctaccgg ctgcgttact cccgggatgg tcgccgctgg      720

atgggctgga aggaccgctg gggtcaggag gtgatctcag gcaatgagga ccctgaggga      780

gtggtgctga aggaccttgg gccccccatg gttgcccgac tggttcgctt ctacccccgg      840

gctgaccggg tcatgagcgt ctgtctgcgg gtagagctct atggctgcct ctggagggat      900

ggactcctgt cttacaccgc ccctgtgggg cagacaatgt atttatctga ggccgtgtac      960

ctcaacgact ccacctatga cggacatacc gtgggcggac tgcagtatgg gggtctgggc     1020

cagctggcag atggtgtggt ggggctggat gactttagga agagtcagga gctgcgggtc     1080

tggccaggct atgactatgt gggatggagc aaccacagct tctccagtgg ctatgtggag     1140

atggagtttg agtttgaccg gctgagggcc ttccaggcta tgcaggtcca ctgtaacaac     1200

atgcacacgc tgggagcccg tctgcctggc ggggtggaat gtcgcttccg gcgtggccct     1260

gccatggcct gggaggggga gcccatgcgc cacaacctag ggggcaacct gggggacccc     1320

agagcccggg ctgtctcagt gccccttggc ggccgtgtgg ctcgctttct gcagtgccgc     1380

ttcctctttg cggggccctg gttactcttc agcgaaatct ccttcatctc tgatgtggtg     1440

aacaattcct ctccggcact gggaggcacc ttcccgccag ccccctggtg gccgcctggc     1500

ccacctccca ccaacttcag cagcttggag ctggagccca gaggccagca gcccgtggcc     1560

aaggccgagg ggagcccgac cgccatcctc atcggctgcc tggtggccat catcctgctc     1620

ctgctgctca tcattgccct catgctctgg cggctgcact ggcgcaggct cctcagcaag     1680

gctgaacgga gggtgttgga agaggagctg acggttcacc tctctgtccc tggggacact     1740

atcctcatca acaaccgccc aggtcctaga gagccacccc cgtaccagga gccccggcct     1800

cgtgggaatc cgccccactc cgctccctgt gtccccaatg gctctgccta cagtggggac     1860

tatatggagc ctgagaagcc aggcgccccg cttctgcccc cacctcccca gaacagcgtc     1920

ccccattatg ccgaggctga cattgttacc ctgcagggcg tcaccggggg caacacctat     1980

gctgtgcctg cactgccccc aggggcagtc ggggatgggc cccccagagt ggatttccct     2040

cgatctcgac tccgcttcaa ggagaagctt ggcgagggcc agtttgggga ggtgcacctg     2100

tgtgaggtcg acagccctca agatctggtt agtcttgatt tcccccttaa tgtgcgtaag     2160

ggacaccctt tgctggtagc tgtcaagatc ttacggccag atgccaccaa gaatgccagg     2220

aatgatttcc tgaaagaggt gaagatcatg tcgaggctca aggacccaaa catcattcgg     2280

ctgctgggcg tgtgtgtgca ggacgacccc ctctgcatga ttactgacta catggagaac     2340

ggcgacctca accagttcct cagtgcccac cagctggagg acaaggcagc cgagggggcc     2400

cctggggacg ggcaggctgc gcaggggccc accatcagct acccaatgct gctgcatgtg     2460

gcagcccaga tcgcctccgg catgcgctat ctggccacac tcaactttgt acatcgggac     2520

ctggccacgc ggaactgcct agttggggaa aatttcacca tcaaaatcgc agactttggc     2580

atgagccgga acctctatgc tggggactat taccgtgtgc agggccgggc agtgctgccc     2640

atccgctgga tggcctggga gtgcatcctc atggggaagt tcacgactgc gagtgacgtg     2700

tgggcctttg gtgtgaccct gtgggaggtg ctgatgctct gtagggccca gccctttggg     2760

cagctcaccg acgagcaggt catcgagaac gcgggggagt tcttccggga ccagggccgg     2820

caggtgtacc tgtcccggcc gcctgcctgc ccgcagggcc tatatgagct gatgcttcgg     2880

tgctggagcc gggagtctga gcagcgacca cccttttccc agctgcatcg gttcctggca     2940

gaggatgcac tcaacacggt gtgaatcaca catccagctg cccctccctc agggagcgat     3000

ccaggggaag ccagtgacac taaaacaaga ggacacaatg gcacctctgc ccttcccctc     3060

ccgacagccc atcacctcta atagaggcag tgagactgca ggtgggctgg gcccacccag     3120

ggagctgatg ccccttctcc ccttcctgga cacactctca tgtccccttc ctgttcttcc     3180

ttcctagaag cccctgtcgc ccacccagct ggtcctgtgg atgggatcct ctccaccctc     3240

ctctagccat cccttgggga agggtgggga gaaatatagg atagacactg gacatggccc     3300

attggagcac ctgggcccca ctggacaaca ctgattcctg gagaggtggc tgcgccccca     3360

gcttctctct ccctgtcaca cactggaccc cactggctga gaatctgggg gtgaggagga     3420

caagaaggag aggaaaatgt ttccttgtgc ctgctcctgt acttgtcctc agcttgggct     3480

tcttcctcct ccatcacctg aaacactgga cctgggggta gccccgcccc agccctcagt     3540

cacccccact tcccacttgc agtcttgtag ctagaacttc tctaagccta tacgtttctg     3600

tggagtaaat attgggattg gggggaaaga gggagcaacg gcccatagcc ttggggttgg     3660

acatctctag tgtagctgcc acattgattt ttctataatc acttggggtt tgtacatttt     3720

tggggggaga gacacagatt tttacactaa tatatggacc tagcttgagg caattttaat     3780

cccctgcact aggcaggtaa taataaaggt tgagttttcc acaaaaaaaa aaaaaaaaaa     3840


<210>  2
<211>  876
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Tyr Ser Gly Asp Tyr Met Glu 
            500                 505                 510         


Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro Pro Pro Gln Asn Ser 
        515                 520                 525             


Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr Leu Gln Gly Val Thr 
    530                 535                 540                 


Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro Pro Gly Ala Val Gly 
545                 550                 555                 560 


Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser Arg Leu Arg Phe Lys 
                565                 570                 575     


Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val His Leu Cys Glu Val 
            580                 585                 590         


Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe Pro Leu Asn Val Arg 
        595                 600                 605             


Lys Gly His Pro Leu Leu Val Ala Val Lys Ile Leu Arg Pro Asp Ala 
    610                 615                 620                 


Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu Val Lys Ile Met Ser 
625                 630                 635                 640 


Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu Gly Val Cys Val Gln 
                645                 650                 655     


Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met Glu Asn Gly Asp Leu 
            660                 665                 670         


Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp Lys Ala Ala Glu Gly 
        675                 680                 685             


Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro Thr Ile Ser Tyr Pro 
    690                 695                 700                 


Met Leu Leu His Val Ala Ala Gln Ile Ala Ser Gly Met Arg Tyr Leu 
705                 710                 715                 720 


Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu 
                725                 730                 735     


Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg 
            740                 745                 750         


Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln Gly Arg Ala Val Leu 
        755                 760                 765             


Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu Met Gly Lys Phe Thr 
    770                 775                 780                 


Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Val Leu 
785                 790                 795                 800 


Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu Thr Asp Glu Gln Val 
                805                 810                 815     


Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Val Tyr 
            820                 825                 830         


Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu Tyr Glu Leu Met Leu 
        835                 840                 845             


Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro Pro Phe Ser Gln Leu 
    850                 855                 860                 


His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr Val 
865                 870                 875     


<210>  3
<211>  3877
<212>  DNA
<213>  Homo sapiens

<400>  3
tgctctcggg agccgcctcc cgacacccga gccccgccgg cgcctcccgc tcccggctcc       60

cggctcctgg ctccctccgc ctcccccgcc cctcgccccg ccgccgaaga ggccccgctc      120

ccgggtcgga cgcctgggtc tgccgggaag agcgatgaga ggtgtctgaa ggtggctatt      180

cactgagcga tggggttgga cttgaaggaa tgccaagaga tgctgccccc acccccttag      240

gcccgaggga tcaggagcta tgggaccaga ggccctgtca tctttactgc tgctgctctt      300

ggtggcaagt ggagatgctg acatgaaggg acattttgat cctgccaagt gccgctatgc      360

cctgggcatg caggaccgga ccatcccaga cagtgacatc tctgcttcca gctcctggtc      420

agattccact gccgcccgcc acagcaggtt ggagagcagt gacggggatg gggcctggtg      480

ccccgcaggg tcggtgtttc ccaaggagga ggagtacttg caggtggatc tacaacgact      540

gcacctggtg gctctggtgg gcacccaggg acggcatgcc gggggcctgg gcaaggagtt      600

ctcccggagc taccggctgc gttactcccg ggatggtcgc cgctggatgg gctggaagga      660

ccgctggggt caggaggtga tctcaggcaa tgaggaccct gagggagtgg tgctgaagga      720

ccttgggccc cccatggttg cccgactggt tcgcttctac ccccgggctg accgggtcat      780

gagcgtctgt ctgcgggtag agctctatgg ctgcctctgg agggatggac tcctgtctta      840

caccgcccct gtggggcaga caatgtattt atctgaggcc gtgtacctca acgactccac      900

ctatgacgga cataccgtgg gcggactgca gtatgggggt ctgggccagc tggcagatgg      960

tgtggtgggg ctggatgact ttaggaagag tcaggagctg cgggtctggc caggctatga     1020

ctatgtggga tggagcaacc acagcttctc cagtggctat gtggagatgg agtttgagtt     1080

tgaccggctg agggccttcc aggctatgca ggtccactgt aacaacatgc acacgctggg     1140

agcccgtctg cctggcgggg tggaatgtcg cttccggcgt ggccctgcca tggcctggga     1200

gggggagccc atgcgccaca acctaggggg caacctgggg gaccccagag cccgggctgt     1260

ctcagtgccc cttggcggcc gtgtggctcg ctttctgcag tgccgcttcc tctttgcggg     1320

gccctggtta ctcttcagcg aaatctcctt catctctgat gtggtgaaca attcctctcc     1380

ggcactggga ggcaccttcc cgccagcccc ctggtggccg cctggcccac ctcccaccaa     1440

cttcagcagc ttggagctgg agcccagagg ccagcagccc gtggccaagg ccgaggggag     1500

cccgaccgcc atcctcatcg gctgcctggt ggccatcatc ctgctcctgc tgctcatcat     1560

tgccctcatg ctctggcggc tgcactggcg caggctcctc agcaaggctg aacggagggt     1620

gttggaagag gagctgacgg ttcacctctc tgtccctggg gacactatcc tcatcaacaa     1680

ccgcccaggt cctagagagc cacccccgta ccaggagccc cggcctcgtg ggaatccgcc     1740

ccactccgct ccctgtgtcc ccaatggctc tgcgttgctg ctctccaatc cagcctaccg     1800

cctccttctg gccacttacg cccgtccccc tcgaggcccg ggccccccca cacccgcctg     1860

ggccaaaccc accaacaccc aggcctacag tggggactat atggagcctg agaagccagg     1920

cgccccgctt ctgcccccac ctccccagaa cagcgtcccc cattatgccg aggctgacat     1980

tgttaccctg cagggcgtca ccgggggcaa cacctatgct gtgcctgcac tgcccccagg     2040

ggcagtcggg gatgggcccc ccagagtgga tttccctcga tctcgactcc gcttcaagga     2100

gaagcttggc gagggccagt ttggggaggt gcacctgtgt gaggtcgaca gccctcaaga     2160

tctggttagt cttgatttcc cccttaatgt gcgtaaggga caccctttgc tggtagctgt     2220

caagatctta cggccagatg ccaccaagaa tgccaggaat gatttcctga aagaggtgaa     2280

gatcatgtcg aggctcaagg acccaaacat cattcggctg ctgggcgtgt gtgtgcagga     2340

cgaccccctc tgcatgatta ctgactacat ggagaacggc gacctcaacc agttcctcag     2400

tgcccaccag ctggaggaca aggcagccga gggggcccct ggggacgggc aggctgcgca     2460

ggggcccacc atcagctacc caatgctgct gcatgtggca gcccagatcg cctccggcat     2520

gcgctatctg gccacactca actttgtaca tcgggacctg gccacgcgga actgcctagt     2580

tggggaaaat ttcaccatca aaatcgcaga ctttggcatg agccggaacc tctatgctgg     2640

ggactattac cgtgtgcagg gccgggcagt gctgcccatc cgctggatgg cctgggagtg     2700

catcctcatg gggaagttca cgactgcgag tgacgtgtgg gcctttggtg tgaccctgtg     2760

ggaggtgctg atgctctgta gggcccagcc ctttgggcag ctcaccgacg agcaggtcat     2820

cgagaacgcg ggggagttct tccgggacca gggccggcag gtgtacctgt cccggccgcc     2880

tgcctgcccg cagggcctat atgagctgat gcttcggtgc tggagccggg agtctgagca     2940

gcgaccaccc ttttcccagc tgcatcggtt cctggcagag gatgcactca acacggtgtg     3000

aatcacacat ccagctgccc ctccctcagg gagcgatcca ggggaagcca gtgacactaa     3060

aacaagagga cacaatggca cctctgccct tcccctcccg acagcccatc acctctaata     3120

gaggcagtga gactgcaggt gggctgggcc cacccaggga gctgatgccc cttctcccct     3180

tcctggacac actctcatgt ccccttcctg ttcttccttc ctagaagccc ctgtcgccca     3240

cccagctggt cctgtggatg ggatcctctc caccctcctc tagccatccc ttggggaagg     3300

gtggggagaa atataggata gacactggac atggcccatt ggagcacctg ggccccactg     3360

gacaacactg attcctggag aggtggctgc gcccccagct tctctctccc tgtcacacac     3420

tggaccccac tggctgagaa tctgggggtg aggaggacaa gaaggagagg aaaatgtttc     3480

cttgtgcctg ctcctgtact tgtcctcagc ttgggcttct tcctcctcca tcacctgaaa     3540

cactggacct gggggtagcc ccgccccagc cctcagtcac ccccacttcc cacttgcagt     3600

cttgtagcta gaacttctct aagcctatac gtttctgtgg agtaaatatt gggattgggg     3660

ggaaagaggg agcaacggcc catagccttg gggttggaca tctctagtgt agctgccaca     3720

ttgatttttc tataatcact tggggtttgt acatttttgg ggggagagac acagattttt     3780

acactaatat atggacctag cttgaggcaa ttttaatccc ctgcactagg caggtaataa     3840

taaaggttga gttttccaca aaaaaaaaaa aaaaaaa                              3877


<210>  4
<211>  913
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala 
            500                 505                 510         


Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly 
        515                 520                 525             


Pro Pro Thr Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser 
    530                 535                 540                 


Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro 
545                 550                 555                 560 


Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr 
                565                 570                 575     


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro 
            580                 585                 590         


Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser 
        595                 600                 605             


Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val 
    610                 615                 620                 


His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe 
625                 630                 635                 640 


Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile 
                645                 650                 655     


Leu Arg Pro Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu 
            660                 665                 670         


Val Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu 
        675                 680                 685             


Gly Val Cys Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met 
    690                 695                 700                 


Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp 
705                 710                 715                 720 


Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro 
                725                 730                 735     


Thr Ile Ser Tyr Pro Met Leu Leu His Val Ala Ala Gln Ile Ala Ser 
            740                 745                 750         


Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala 
        755                 760                 765             


Thr Arg Asn Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp 
    770                 775                 780                 


Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln 
785                 790                 795                 800 


Gly Arg Ala Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu 
                805                 810                 815     


Met Gly Lys Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr 
            820                 825                 830         


Leu Trp Glu Val Leu Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu 
        835                 840                 845             


Thr Asp Glu Gln Val Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln 
    850                 855                 860                 


Gly Arg Gln Val Tyr Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu 
865                 870                 875                 880 


Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro 
                885                 890                 895     


Pro Phe Ser Gln Leu His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr 
            900                 905                 910         


Val 
    


<210>  5
<211>  3678
<212>  DNA
<213>  Homo sapiens

<400>  5
agatgctgcc cccaccccct taggcccgag ggatcaggag ctatgggacc agaggccctg       60

tcatctttac tgctgctgct cttggtggca agtggagatg ctgacatgaa gggacatttt      120

gatcctgcca agtgccgcta tgccctgggc atgcaggacc ggaccatccc agacagtgac      180

atctctgctt ccagctcctg gtcagattcc actgccgccc gccacagcag gttggagagc      240

agtgacgggg atggggcctg gtgccccgca gggtcggtgt ttcccaagga ggaggagtac      300

ttgcaggtgg atctacaacg actgcacctg gtggctctgg tgggcaccca gggacggcat      360

gccgggggcc tgggcaagga gttctcccgg agctaccggc tgcgttactc ccgggatggt      420

cgccgctgga tgggctggaa ggaccgctgg ggtcaggagg tgatctcagg caatgaggac      480

cctgagggag tggtgctgaa ggaccttggg ccccccatgg ttgcccgact ggttcgcttc      540

tacccccggg ctgaccgggt catgagcgtc tgtctgcggg tagagctcta tggctgcctc      600

tggagggatg gactcctgtc ttacaccgcc cctgtggggc agacaatgta tttatctgag      660

gccgtgtacc tcaacgactc cacctatgac ggacataccg tgggcggact gcagtatggg      720

ggtctgggcc agctggcaga tggtgtggtg gggctggatg actttaggaa gagtcaggag      780

ctgcgggtct ggccaggcta tgactatgtg ggatggagca accacagctt ctccagtggc      840

tatgtggaga tggagtttga gtttgaccgg ctgagggcct tccaggctat gcaggtccac      900

tgtaacaaca tgcacacgct gggagcccgt ctgcctggcg gggtggaatg tcgcttccgg      960

cgtggccctg ccatggcctg ggagggggag cccatgcgcc acaacctagg gggcaacctg     1020

ggggacccca gagcccgggc tgtctcagtg ccccttggcg gccgtgtggc tcgctttctg     1080

cagtgccgct tcctctttgc ggggccctgg ttactcttca gcgaaatctc cttcatctct     1140

gatgtggtga acaattcctc tccggcactg ggaggcacct tcccgccagc cccctggtgg     1200

ccgcctggcc cacctcccac caacttcagc agcttggagc tggagcccag aggccagcag     1260

cccgtggcca aggccgaggg gagcccgacc gccatcctca tcggctgcct ggtggccatc     1320

atcctgctcc tgctgctcat cattgccctc atgctctggc ggctgcactg gcgcaggctc     1380

ctcagcaagg ctgaacggag ggtgttggaa gaggagctga cggttcacct ctctgtccct     1440

ggggacacta tcctcatcaa caaccgccca ggtcctagag agccaccccc gtaccaggag     1500

ccccggcctc gtgggaatcc gccccactcc gctccctgtg tccccaatgg ctctgcgttg     1560

ctgctctcca atccagccta ccgcctcctt ctggccactt acgcccgtcc ccctcgaggc     1620

ccgggccccc ccacacccgc ctgggccaaa cccaccaaca cccaggccta cagtggggac     1680

tatatggagc ctgagaagcc aggcgccccg cttctgcccc cacctcccca gaacagcgtc     1740

ccccattatg ccgaggctga cattgttacc ctgcagggcg tcaccggggg caacacctat     1800

gctgtgcctg cactgccccc aggggcagtc ggggatgggc cccccagagt ggatttccct     1860

cgatctcgac tccgcttcaa ggagaagctt ggcgagggcc agtttgggga ggtgcacctg     1920

tgtgaggtcg acagccctca agatctggtt agtcttgatt tcccccttaa tgtgcgtaag     1980

ggacaccctt tgctggtagc tgtcaagatc ttacggccag atgccaccaa gaatgccagc     2040

ttctccttgt tctccaggaa tgatttcctg aaagaggtga agatcatgtc gaggctcaag     2100

gacccaaaca tcattcggct gctgggcgtg tgtgtgcagg acgaccccct ctgcatgatt     2160

actgactaca tggagaacgg cgacctcaac cagttcctca gtgcccacca gctggaggac     2220

aaggcagccg agggggcccc tggggacggg caggctgcgc aggggcccac catcagctac     2280

ccaatgctgc tgcatgtggc agcccagatc gcctccggca tgcgctatct ggccacactc     2340

aactttgtac atcgggacct ggccacgcgg aactgcctag ttggggaaaa tttcaccatc     2400

aaaatcgcag actttggcat gagccggaac ctctatgctg gggactatta ccgtgtgcag     2460

ggccgggcag tgctgcccat ccgctggatg gcctgggagt gcatcctcat ggggaagttc     2520

acgactgcga gtgacgtgtg ggcctttggt gtgaccctgt gggaggtgct gatgctctgt     2580

agggcccagc cctttgggca gctcaccgac gagcaggtca tcgagaacgc gggggagttc     2640

ttccgggacc agggccggca ggtgtacctg tcccggccgc ctgcctgccc gcagggccta     2700

tatgagctga tgcttcggtg ctggagccgg gagtctgagc agcgaccacc cttttcccag     2760

ctgcatcggt tcctggcaga ggatgcactc aacacggtgt gaatcacaca tccagctgcc     2820

cctccctcag ggagcgatcc aggggaagcc agtgacacta aaacaagagg acacaatggc     2880

acctctgccc ttcccctccc gacagcccat cacctctaat agaggcagtg agactgcagg     2940

tgggctgggc ccacccaggg agctgatgcc ccttctcccc ttcctggaca cactctcatg     3000

tccccttcct gttcttcctt cctagaagcc cctgtcgccc acccagctgg tcctgtggat     3060

gggatcctct ccaccctcct ctagccatcc cttggggaag ggtggggaga aatataggat     3120

agacactgga catggcccat tggagcacct gggccccact ggacaacact gattcctgga     3180

gaggtggctg cgcccccagc ttctctctcc ctgtcacaca ctggacccca ctggctgaga     3240

atctgggggt gaggaggaca agaaggagag gaaaatgttt ccttgtgcct gctcctgtac     3300

ttgtcctcag cttgggcttc ttcctcctcc atcacctgaa acactggacc tgggggtagc     3360

cccgccccag ccctcagtca cccccacttc ccacttgcag tcttgtagct agaacttctc     3420

taagcctata cgtttctgtg gagtaaatat tgggattggg gggaaagagg gagcaacggc     3480

ccatagcctt ggggttggac atctctagtg tagctgccac attgattttt ctataatcac     3540

ttggggtttg tacatttttg gggggagaga cacagatttt tacactaata tatggaccta     3600

gcttgaggca attttaatcc cctgcactag gcaggtaata ataaaggttg agttttccac     3660

aaaaaaaaaa aaaaaaaa                                                   3678


<210>  6
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala 
            500                 505                 510         


Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly 
        515                 520                 525             


Pro Pro Thr Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser 
    530                 535                 540                 


Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro 
545                 550                 555                 560 


Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr 
                565                 570                 575     


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro 
            580                 585                 590         


Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser 
        595                 600                 605             


Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val 
    610                 615                 620                 


His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe 
625                 630                 635                 640 


Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile 
                645                 650                 655     


Leu Arg Pro Asp Ala Thr Lys Asn Ala Ser Phe Ser Leu Phe Ser Arg 
            660                 665                 670         


Asn Asp Phe Leu Lys Glu Val Lys Ile Met Ser Arg Leu Lys Asp Pro 
        675                 680                 685             


Asn Ile Ile Arg Leu Leu Gly Val Cys Val Gln Asp Asp Pro Leu Cys 
    690                 695                 700                 


Met Ile Thr Asp Tyr Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser 
705                 710                 715                 720 


Ala His Gln Leu Glu Asp Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly 
                725                 730                 735     


Gln Ala Ala Gln Gly Pro Thr Ile Ser Tyr Pro Met Leu Leu His Val 
            740                 745                 750         


Ala Ala Gln Ile Ala Ser Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe 
        755                 760                 765             


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Phe 
    770                 775                 780                 


Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly 
785                 790                 795                 800 


Asp Tyr Tyr Arg Val Gln Gly Arg Ala Val Leu Pro Ile Arg Trp Met 
                805                 810                 815     


Ala Trp Glu Cys Ile Leu Met Gly Lys Phe Thr Thr Ala Ser Asp Val 
            820                 825                 830         


Trp Ala Phe Gly Val Thr Leu Trp Glu Val Leu Met Leu Cys Arg Ala 
        835                 840                 845             


Gln Pro Phe Gly Gln Leu Thr Asp Glu Gln Val Ile Glu Asn Ala Gly 
    850                 855                 860                 


Glu Phe Phe Arg Asp Gln Gly Arg Gln Val Tyr Leu Ser Arg Pro Pro 
865                 870                 875                 880 


Ala Cys Pro Gln Gly Leu Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg 
                885                 890                 895     


Glu Ser Glu Gln Arg Pro Pro Phe Ser Gln Leu His Arg Phe Leu Ala 
            900                 905                 910         


Glu Asp Ala Leu Asn Thr Val 
        915                 


<210>  7
<211>  3252
<212>  DNA
<213>  Homo sapiens

<400>  7
gaatcctcag aatgtgaggt ttctctcaaa ggcatcttgc atcagcctgt ggatgtatgc       60

ctaccaccgg gctccttcac cagcaaagtg gaaaaagaag cgtttcacaa caaattcttc      120

tttttgggtt ggggaaacgc agtggattat agctctgttt tcttctttcc aaaactgtgc      180

acccctggat gaaacctcca tcaagggaga cctacaagtt gcctggggtt cagtgctcta      240

gaaagttcca aggtttgtgg cttgaattat tctaaagaag ctgaaataat tgaagagaag      300

cagaggccag ctgtttttga ggatcctgct ccacagagaa tgctctgcac ccgttgatat      360

gcctcccagg acccagaggg agactgtagc ctcatttctg tggagacctt tggctggact      420

ctcctggctc tcccagagac tccagttcca acaccatctt ctgagatgat cctgattccc      480

agaatgctct tggtgctgtt cctgctgctg cctatcttga gttctgcaaa agctcaggtt      540

aatccagcta tatgccgcta tcctctgggc atgtcaggag gccagattcc agatgaggac      600

atcacagctt ccagtcagtg gtcagagtcc acagctgcca aatatggaag gctggactca      660

gaagaagggg atggagcctg gtgccctgag attccagtgg aacctgatga cctgaaggag      720

tttctgcaga ttgacttgca caccctccat tttatcactc tggtggggac ccaggggcgc      780

catgcaggag gtcatggcat cgagtttgcc cccatgtaca agatcaatta cagtcgggat      840

ggcactcgct ggatctcttg gcggaaccgt catgggaaac aggtgctgga tggaaatagt      900

aacccctatg acattttcct aaaggacttg gagccgccca ttgtagccag atttgtccgg      960

ttcattccag tcaccgacca ctccatgaat gtgtgtatga gagtggagct ttacggctgt     1020

gtctggctag atggcttggt gtcttacaat gctccagctg ggcagcagtt tgtactccct     1080

ggaggttcca tcatttatct gaatgattct gtctatgatg gagctgttgg atacagcatg     1140

acagaagggc taggccaatt gaccgatggt gtgtctggcc tggacgattt cacccagacc     1200

catgaatacc acgtgtggcc cggctatgac tatgtgggct ggcggaacga gagtgccacc     1260

aatggctaca ttgagatcat gtttgaattt gaccgcatca ggaatttcac taccatgaag     1320

gtccactgca acaacatgtt tgctaaaggt gtgaagatct ttaaggaggt acagtgctac     1380

ttccgctctg aagccagtga gtgggaacct aatgccattt ccttccccct tgtcctggat     1440

gacgtcaacc ccagtgctcg gtttgtcacg gtgcctctcc accaccgaat ggccagtgcc     1500

atcaagtgtc aataccattt tgcagatacc tggatgatgt tcagtgagat caccttccaa     1560

tcagatgctg caatgtacaa caactctgaa gccctgccca cctctcctat ggcacccaca     1620

acctatgatc caatgcttaa agttgatgac agcaacactc ggatcctgat tggctgcttg     1680

gtggccatca tctttatcct cctggccatc attgtcatca tcctctggag gcagttctgg     1740

cagaaaatgc tggagaaggc ttctcggagg atgctggatg atgaaatgac agtcagcctt     1800

tccctgccaa gtgattctag catgttcaac aataaccgct cctcatcacc tagtgaacaa     1860

gggtccaact cgacttacga tcgcatcttt ccccttcgcc ctgactacca ggagccatcc     1920

aggctgatac gaaaactccc agaatttgct ccaggggagg aggagtcagg ctgcagcggt     1980

gttgtgaagc cagtccagcc cagtggccct gagggggtgc cccactatgc agaggctgac     2040

atagtgaacc tccaaggagt gacaggaggc aacacatact cagtgcctgc cgtcaccatg     2100

gacctgctct caggaaaaga tgtggctgtg gaggagttcc ccaggaaact cctaactttc     2160

aaagagaagc tgggagaagg acagtttggg gaggttcatc tctgtgaagt ggagggaatg     2220

gaaaaattca aagacaaaga ttttgcccta gatgtcagtg ccaaccagcc tgtcctggtg     2280

gctgtgaaaa tgctccgagc agatgccaac aagaatgcca ggaatgattt tcttaaggag     2340

ataaagatca tgtctcggct caaggaccca aacatcatcc atctattagc tgtgtgtatc     2400

actgatgacc ctctctgtat gatcactgaa tacatggaga atggagatct caatcagttt     2460

ctttcccgcc acgagccccc taattcttcc tccagcgatg tacgcactgt cagttacacc     2520

aatctgaagt ttatggctac ccaaattgcc tctggcatga agtacctttc ctctcttaat     2580

tttgttcacc gagatctggc cacacgaaac tgtttagtgg gtaagaacta cacaatcaag     2640

atagctgact ttggaatgag caggaacctg tacagtggtg actattaccg gatccagggc     2700

cgggcagtgc tccctatccg ctggatgtct tgggagagta tcttgctggg caagttcact     2760

acagcaagtg atgtgtgggc ctttggggtt actttgtggg agactttcac cttttgtcaa     2820

gaacagccct attcccagct gtcagatgaa caggttattg agaatactgg agagttcttc     2880

cgagaccaag ggaggcagac ttacctccct caaccagcca tttgtcctga ctctgtgtat     2940

aagctgatgc tcagctgctg gagaagagat acgaagaacc gtccctcatt ccaagaaatc     3000

caccttctgc tccttcaaca aggcgacgag tgatgctgtc agtgcctggc catgttccta     3060

cggctcaggt cctccctaca agacctacca ctcacccatg cctatgccac tccatctgga     3120

catttaatga aactgagaga cagaggcttg tttgctttgc cctcttttcc tggtcacccc     3180

cactccctac ccctgactca tatatacttt tttttttttt tacattaaag aactaaaaaa     3240

ggaaaaaaaa aa                                                         3252


<210>  8
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ile Leu Ile Pro Arg Met Leu Leu Val Leu Phe Leu Leu Leu Pro 
1               5                   10                  15      


Ile Leu Ser Ser Ala Lys Ala Gln Val Asn Pro Ala Ile Cys Arg Tyr 
            20                  25                  30          


Pro Leu Gly Met Ser Gly Gly Gln Ile Pro Asp Glu Asp Ile Thr Ala 
        35                  40                  45              


Ser Ser Gln Trp Ser Glu Ser Thr Ala Ala Lys Tyr Gly Arg Leu Asp 
    50                  55                  60                  


Ser Glu Glu Gly Asp Gly Ala Trp Cys Pro Glu Ile Pro Val Glu Pro 
65                  70                  75                  80  


Asp Asp Leu Lys Glu Phe Leu Gln Ile Asp Leu His Thr Leu His Phe 
                85                  90                  95      


Ile Thr Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly His Gly Ile 
            100                 105                 110         


Glu Phe Ala Pro Met Tyr Lys Ile Asn Tyr Ser Arg Asp Gly Thr Arg 
        115                 120                 125             


Trp Ile Ser Trp Arg Asn Arg His Gly Lys Gln Val Leu Asp Gly Asn 
    130                 135                 140                 


Ser Asn Pro Tyr Asp Ile Phe Leu Lys Asp Leu Glu Pro Pro Ile Val 
145                 150                 155                 160 


Ala Arg Phe Val Arg Phe Ile Pro Val Thr Asp His Ser Met Asn Val 
                165                 170                 175     


Cys Met Arg Val Glu Leu Tyr Gly Cys Val Trp Leu Asp Gly Leu Val 
            180                 185                 190         


Ser Tyr Asn Ala Pro Ala Gly Gln Gln Phe Val Leu Pro Gly Gly Ser 
        195                 200                 205             


Ile Ile Tyr Leu Asn Asp Ser Val Tyr Asp Gly Ala Val Gly Tyr Ser 
    210                 215                 220                 


Met Thr Glu Gly Leu Gly Gln Leu Thr Asp Gly Val Ser Gly Leu Asp 
225                 230                 235                 240 


Asp Phe Thr Gln Thr His Glu Tyr His Val Trp Pro Gly Tyr Asp Tyr 
                245                 250                 255     


Val Gly Trp Arg Asn Glu Ser Ala Thr Asn Gly Tyr Ile Glu Ile Met 
            260                 265                 270         


Phe Glu Phe Asp Arg Ile Arg Asn Phe Thr Thr Met Lys Val His Cys 
        275                 280                 285             


Asn Asn Met Phe Ala Lys Gly Val Lys Ile Phe Lys Glu Val Gln Cys 
    290                 295                 300                 


Tyr Phe Arg Ser Glu Ala Ser Glu Trp Glu Pro Asn Ala Ile Ser Phe 
305                 310                 315                 320 


Pro Leu Val Leu Asp Asp Val Asn Pro Ser Ala Arg Phe Val Thr Val 
                325                 330                 335     


Pro Leu His His Arg Met Ala Ser Ala Ile Lys Cys Gln Tyr His Phe 
            340                 345                 350         


Ala Asp Thr Trp Met Met Phe Ser Glu Ile Thr Phe Gln Ser Asp Ala 
        355                 360                 365             


Ala Met Tyr Asn Asn Ser Glu Ala Leu Pro Thr Ser Pro Met Ala Pro 
    370                 375                 380                 


Thr Thr Tyr Asp Pro Met Leu Lys Val Asp Asp Ser Asn Thr Arg Ile 
385                 390                 395                 400 


Leu Ile Gly Cys Leu Val Ala Ile Ile Phe Ile Leu Leu Ala Ile Ile 
                405                 410                 415     


Val Ile Ile Leu Trp Arg Gln Phe Trp Gln Lys Met Leu Glu Lys Ala 
            420                 425                 430         


Ser Arg Arg Met Leu Asp Asp Glu Met Thr Val Ser Leu Ser Leu Pro 
        435                 440                 445             


Ser Asp Ser Ser Met Phe Asn Asn Asn Arg Ser Ser Ser Pro Ser Glu 
    450                 455                 460                 


Gln Gly Ser Asn Ser Thr Tyr Asp Arg Ile Phe Pro Leu Arg Pro Asp 
465                 470                 475                 480 


Tyr Gln Glu Pro Ser Arg Leu Ile Arg Lys Leu Pro Glu Phe Ala Pro 
                485                 490                 495     


Gly Glu Glu Glu Ser Gly Cys Ser Gly Val Val Lys Pro Val Gln Pro 
            500                 505                 510         


Ser Gly Pro Glu Gly Val Pro His Tyr Ala Glu Ala Asp Ile Val Asn 
        515                 520                 525             


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ser Val Pro Ala Val Thr 
    530                 535                 540                 


Met Asp Leu Leu Ser Gly Lys Asp Val Ala Val Glu Glu Phe Pro Arg 
545                 550                 555                 560 


Lys Leu Leu Thr Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu 
                565                 570                 575     


Val His Leu Cys Glu Val Glu Gly Met Glu Lys Phe Lys Asp Lys Asp 
            580                 585                 590         


Phe Ala Leu Asp Val Ser Ala Asn Gln Pro Val Leu Val Ala Val Lys 
        595                 600                 605             


Met Leu Arg Ala Asp Ala Asn Lys Asn Ala Arg Asn Asp Phe Leu Lys 
    610                 615                 620                 


Glu Ile Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile His Leu 
625                 630                 635                 640 


Leu Ala Val Cys Ile Thr Asp Asp Pro Leu Cys Met Ile Thr Glu Tyr 
                645                 650                 655     


Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Arg His Glu Pro Pro 
            660                 665                 670         


Asn Ser Ser Ser Ser Asp Val Arg Thr Val Ser Tyr Thr Asn Leu Lys 
        675                 680                 685             


Phe Met Ala Thr Gln Ile Ala Ser Gly Met Lys Tyr Leu Ser Ser Leu 
    690                 695                 700                 


Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Lys 
705                 710                 715                 720 


Asn Tyr Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu Tyr 
                725                 730                 735     


Ser Gly Asp Tyr Tyr Arg Ile Gln Gly Arg Ala Val Leu Pro Ile Arg 
            740                 745                 750         


Trp Met Ser Trp Glu Ser Ile Leu Leu Gly Lys Phe Thr Thr Ala Ser 
        755                 760                 765             


Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Thr Phe Thr Phe Cys 
    770                 775                 780                 


Gln Glu Gln Pro Tyr Ser Gln Leu Ser Asp Glu Gln Val Ile Glu Asn 
785                 790                 795                 800 


Thr Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Thr Tyr Leu Pro Gln 
                805                 810                 815     


Pro Ala Ile Cys Pro Asp Ser Val Tyr Lys Leu Met Leu Ser Cys Trp 
            820                 825                 830         


Arg Arg Asp Thr Lys Asn Arg Pro Ser Phe Gln Glu Ile His Leu Leu 
        835                 840                 845             


Leu Leu Gln Gln Gly Asp Glu 
    850                 855 


<210>  9
<211>  3703
<212>  DNA
<213>  Mus musculus

<400>  9
gctgtcccct ccctctctgc gggggctgag aggctcagcg aggggagcag agctgggttg       60

ccatggtcac cttgaagcca gccgcagctg gccagggcag ctgctcttgg gcccccgagg      120

ctggagcttg gacaaagccg ggaggcttca tcggcctcag acctggatcc ccaaaggcgt      180

gtgcctaggg agactgaaac tcaggagaac ctggagagat gctgtcccct cctccataga      240

ccagagggat ccagagcgat ggggacaggg accctctcat ctctactgct gctgctactc      300

ttggtgacaa ttggagatgc tgacatgaag ggacattttg accctgccaa gtgccgctat      360

gccctgggca tgcaggaccg caccattcct gacagcgata tctctgtgtc cagctcctgg      420

tcggactcta ccgctgcccg ccacagcagg ctggaaagca gtgatggaga tggggcttgg      480

tgccctgcag ggcctgtgtt ccccaaagaa gaggagtact tgcaggtgga ccttcgtagg      540

ctacacctgg tggctctggt gggcacccag ggccgccatg ctgggggtct gggcaaagag      600

ttctcccgaa gctatcggtt gcgttactcc cgagatggcc gccgctggat ggactggaag      660

gaccgctggg gacaggaggt gatttcgggt aacgaggatc ccgggggagt agtgctgaag      720

gaccttgggc cccccatggt ggcccggctg gtccgcttct accccagggc tgaccgggtc      780

atgagtgtct gtcttcgggt ggagctctat ggctgcctct ggcgggatgg actcctgtca      840

tatacagccc ccgtggggca gaccatgcag ttatctgagg tgatggtaca tctcaatgat      900

tccacttacg atggatatac tgctggaggg ctgcagtatg gcggtctggg ccagctggca      960

gatggcgtgg tgggcctgga tgatttcagg cagagccagg agctgcgggt ctggccaggc     1020

tatgactatg tgggatggag caatcagagc ttccccacgg gctacgtgga gatggagttt     1080

gagtttgatc ggttgaggac cttccagacc atgcaggtcc actgtaacaa catgcacact     1140

ctgggagccc gcctaccagg cggggtggaa tgccggttta aaaggggtcc cgccatggcc     1200

tgggaaggag agcctgtccg ccatgctctg ggaggcagcc ttggagaccc cagagcccgg     1260

gccatctcag tgcccctggg tggccacgtg ggccgctttc tgcagtgcag attcctcttt     1320

gcaggtcctt ggttactctt cagtgagatc tctttcatct cagatgtggt gaacgactcc     1380

tctgacacct tcccaccagc cccctggtgg ccacctggcc cgcctcccac caacttcagc     1440

agcttggagc tggagccccg gggtcaacag ccagtggcca aggcggaggg gagcccaact     1500

gccatcctca ttggctgcct ggtggccatc atcctgctgc tgcttctcat catcgcgctg     1560

atgctctgga ggctgcactg gcgccggctg ctcagcaagg ctgagcgccg cgtgttggag     1620

gaggagctga cggttcacct ttctgtccct ggggacacca tcctcatcaa caaccgccca     1680

ggaccccgag agccaccccc ttaccaggag ccccggcctc gggggactcc accccattct     1740

gcaccctgcg tccccaacgg ctctgcctgc agtggggact atatggagcc cgagaagccg     1800

ggtgccccgc ttctaccccc acctccccag aacagcgtcc cccattatgc cgaagctgac     1860

attgtcaccc tgcagggcgt cactgggggc aacacctacg ctgtgcctgc actgccccca     1920

ggggcggttg gggatgggcc ccccagagtg gatttccctc ggtcacggct ccgcttcaag     1980

gagaagcttg gcgagggcca atttggggag gtacacctgt gtgaagtaga ggacccgcaa     2040

gatctggtca gtagtgactt ccctatcagt gtgcacaagg gacacccctt gctggtagca     2100

gtgaagatcc tccggccaga tgccaccaaa aatgccagga atgatttcct gaaggaggta     2160

aagatcatgt cacggctgaa ggacccaaac atcatccggc tcctgggtgt gtgtgtgcag     2220

gatgaccccc tctgcatgat cacagactac atggagaacg gcgatctgaa ccagttcctc     2280

agtgcccgcc agctggagaa caaggccact caggggctct ctggggacac agagtctgac     2340

caggggccca caatcagcta ccctatgctg ttacacgtgg gggcccagat cgcctctggc     2400

atgcgttatc tcgccacgct gaactttgtg catcgggacc tggccacccg gaactgcttg     2460

gttggggaaa atttcaccat caaaatcgcc gactttggca tgagccggaa tctctacgct     2520

ggggattatt accgtgtcca gggccgggcg gtgctgccca tcaggtggat ggcttgggag     2580

tgcattctca tggggaagtt cacaacagcc agtgacgttt gggccttcgg agtgaccctg     2640

tgggaggtgc tgatgctctg caggtcccag ccctttgggc agcttacaga tgagcaggtt     2700

atcgagaatg ccggcgagtt cttcagggac cagggccggc aggtctactt gtccaggcca     2760

cccgcctgcc cacagaccct gtatgagctg atgctccggt gttggagccg ggagcccgag     2820

cagcggccgc ccttcgccca gcttcatcgg ttcctggcgg atgatgcgct caacacggtg     2880

taaactcagg acccggcagc cctttcccaa tgggagccat ccaggggaag ctggactcga     2940

aaaccagaga agcctatggc accgcacccc accgtctcca tacttgccca ttcccaagag     3000

gcagtgtctc tgcgggtggg ctgggcctgc ccgaggagca gatacacaca ctcccttccg     3060

tttcttcctt ccatctgcca agtgccaccc tcccagctgg ccctgtggtt gggatcctgc     3120

ctgacttctt ccagctatcc ccttggggaa gaacgggggc aaatgctggg cgtacactgg     3180

acaaggccca ctggacaaca ctggttcctg ggaggtgacg gtgcccccca gctttcttct     3240

tgtcacacac tggacgccgc cagctgagaa ttagaggggt gagggggaca aggacggcca     3300

acccctacag cggtcctcag ccctggcttc cttctgttcc gccccctgac acactggacc     3360

tgggggcgat ccctgccgtt gatcctcagt cacacacccc tccttctcac ctgccatgct     3420

gcagctagaa cttcgcaaag cctctatgtt tctgtggagt aaatattagg atggggaaca     3480

gagggagcaa tagcttgagg ctgggggtgg ggatttctat tgtagctacc acattggttt     3540

ttctataatc acgcggggtt tgtacatttt ttggggggag agaaacacag atttttacac     3600

taatatatgg acctagctta aggcgatttt aatcccctgt cctaggcagg taataataaa     3660

agttgagttg ttttttgttt tttgtttttc cacaaaaaaa aaa                       3703


<210>  10
<211>  874
<212>  PRT
<213>  Mus musculus

<400>  10

Met Gly Thr Gly Thr Leu Ser Ser Leu Leu Leu Leu Leu Leu Leu Val 
1               5                   10                  15      


Thr Ile Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys 
            20                  25                  30          


Arg Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile 
        35                  40                  45              


Ser Val Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg 
    50                  55                  60                  


Leu Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Pro Val 
65                  70                  75                  80  


Phe Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Arg Arg Leu His 
                85                  90                  95      


Leu Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly 
            100                 105                 110         


Lys Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg 
        115                 120                 125             


Arg Trp Met Asp Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly 
    130                 135                 140                 


Asn Glu Asp Pro Gly Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met 
145                 150                 155                 160 


Val Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser 
                165                 170                 175     


Val Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu 
            180                 185                 190         


Leu Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Gln Leu Ser Glu Val 
        195                 200                 205             


Met Val His Leu Asn Asp Ser Thr Tyr Asp Gly Tyr Thr Ala Gly Gly 
    210                 215                 220                 


Leu Gln Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu 
225                 230                 235                 240 


Asp Asp Phe Arg Gln Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp 
                245                 250                 255     


Tyr Val Gly Trp Ser Asn Gln Ser Phe Pro Thr Gly Tyr Val Glu Met 
            260                 265                 270         


Glu Phe Glu Phe Asp Arg Leu Arg Thr Phe Gln Thr Met Gln Val His 
        275                 280                 285             


Cys Asn Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu 
    290                 295                 300                 


Cys Arg Phe Lys Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Val 
305                 310                 315                 320 


Arg His Ala Leu Gly Gly Ser Leu Gly Asp Pro Arg Ala Arg Ala Ile 
                325                 330                 335     


Ser Val Pro Leu Gly Gly His Val Gly Arg Phe Leu Gln Cys Arg Phe 
            340                 345                 350         


Leu Phe Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser 
        355                 360                 365             


Asp Val Val Asn Asp Ser Ser Asp Thr Phe Pro Pro Ala Pro Trp Trp 
    370                 375                 380                 


Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu Glu Pro 
385                 390                 395                 400 


Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr Ala Ile 
                405                 410                 415     


Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu Ile Ile 
            420                 425                 430         


Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser Lys Ala 
        435                 440                 445             


Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser Val Pro 
    450                 455                 460                 


Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu Pro Pro 
465                 470                 475                 480 


Pro Tyr Gln Glu Pro Arg Pro Arg Gly Thr Pro Pro His Ser Ala Pro 
                485                 490                 495     


Cys Val Pro Asn Gly Ser Ala Cys Ser Gly Asp Tyr Met Glu Pro Glu 
            500                 505                 510         


Lys Pro Gly Ala Pro Leu Leu Pro Pro Pro Pro Gln Asn Ser Val Pro 
        515                 520                 525             


His Tyr Ala Glu Ala Asp Ile Val Thr Leu Gln Gly Val Thr Gly Gly 
    530                 535                 540                 


Asn Thr Tyr Ala Val Pro Ala Leu Pro Pro Gly Ala Val Gly Asp Gly 
545                 550                 555                 560 


Pro Pro Arg Val Asp Phe Pro Arg Ser Arg Leu Arg Phe Lys Glu Lys 
                565                 570                 575     


Leu Gly Glu Gly Gln Phe Gly Glu Val His Leu Cys Glu Val Glu Asp 
            580                 585                 590         


Pro Gln Asp Leu Val Ser Ser Asp Phe Pro Ile Ser Val His Lys Gly 
        595                 600                 605             


His Pro Leu Leu Val Ala Val Lys Ile Leu Arg Pro Asp Ala Thr Lys 
    610                 615                 620                 


Asn Ala Arg Asn Asp Phe Leu Lys Glu Val Lys Ile Met Ser Arg Leu 
625                 630                 635                 640 


Lys Asp Pro Asn Ile Ile Arg Leu Leu Gly Val Cys Val Gln Asp Asp 
                645                 650                 655     


Pro Leu Cys Met Ile Thr Asp Tyr Met Glu Asn Gly Asp Leu Asn Gln 
            660                 665                 670         


Phe Leu Ser Ala Arg Gln Leu Glu Asn Lys Ala Thr Gln Gly Leu Ser 
        675                 680                 685             


Gly Asp Thr Glu Ser Asp Gln Gly Pro Thr Ile Ser Tyr Pro Met Leu 
    690                 695                 700                 


Leu His Val Gly Ala Gln Ile Ala Ser Gly Met Arg Tyr Leu Ala Thr 
705                 710                 715                 720 


Leu Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly 
                725                 730                 735     


Glu Asn Phe Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu 
            740                 745                 750         


Tyr Ala Gly Asp Tyr Tyr Arg Val Gln Gly Arg Ala Val Leu Pro Ile 
        755                 760                 765             


Arg Trp Met Ala Trp Glu Cys Ile Leu Met Gly Lys Phe Thr Thr Ala 
    770                 775                 780                 


Ser Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Val Leu Met Leu 
785                 790                 795                 800 


Cys Arg Ser Gln Pro Phe Gly Gln Leu Thr Asp Glu Gln Val Ile Glu 
                805                 810                 815     


Asn Ala Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Val Tyr Leu Ser 
            820                 825                 830         


Arg Pro Pro Ala Cys Pro Gln Thr Leu Tyr Glu Leu Met Leu Arg Cys 
        835                 840                 845             


Trp Ser Arg Glu Pro Glu Gln Arg Pro Pro Phe Ala Gln Leu His Arg 
    850                 855                 860                 


Phe Leu Ala Asp Asp Ala Leu Asn Thr Val 
865                 870                 


<210>  11
<211>  2834
<212>  DNA
<213>  Rattus norvegicus

<400>  11
cctccacgcc ccggccagcc tctgcaggac ccagatttcc catcgctgtc tgcagaggga       60

gatgctgtcc cctcctccat aggccagagg gatcaggagc gatggggaca gggaccctct      120

catctctcct gctgctgcta ctcttggtga caattggaga tgctgacatg aagggacatt      180

ttgacccagc caagtgccgc tatgccctgg gcatgcagga ccgcaccatt ccagacagcg      240

atatctctgt gtccagctcc tggtcggact ctaccgccgc ccgccacagc aggctggaaa      300

gcagtgatgg agatggggct tggtgccctg cagggcctgt gttccccaaa gaagaggagt      360

acctgcaggt ggaccttcgt aggctacacc tggtggctct ggtgggcacc cagggccgcc      420

atgctggggg tctgggcaaa gagttctccc gaagctaccg gttgcgttac tcccgagatg      480

gccgacgatg gatggactgg aaagacagat ggggtcagga ggtgatttcg ggtaacgagg      540

atcctggggg agtggtgctg aaggatctcg ggccccccat ggtggcccgg ctggtccgtt      600

tctaccccag ggctgaccgg gtcatgagtg tctgtcttcg ggtggagctc tatggctgcc      660

tctggcggga cggactcttg tcctatacag cccccgtggg gcagaccatg caattatctg      720

agatggtgta tctcaatgat tccacttacg atggatatac tgctggaggg ctgcagtacg      780

gtggtctggg ccaactggca gacggcgtgg tggggctgga tgatttcagg cagagccagg      840

agctgcgggt ttggccaggc tatgactatg tgggatggag caaccatagc ttccccagcg      900

gctacgtgga gatggagttt gagtttgacc ggctgaggtc tttccagacc atgcaggtcc      960

actgtaacaa catgcacact ctgggagccc gcctcccagg cggggtggaa tgccggttta     1020

aaaggggtcc ggccatggcc tgggaaggag agcctgtacg ccatgccctg gggggtagcc     1080

ttggagaccc cagagccagg gccatctcgg tgcccctggg tggtcacgtg ggccgcttcc     1140

tgcagtgcag attcctcttt gcaggaccct ggttactctt cagtgagatc tctttcatct     1200

cggatgtggt gaacgactcg tctgacacct tcccaccagc cccctggtgg ccgcctggcc     1260

cgcctcccac caacttcagc agcttggagc tggagccccg gggtcaacag cctgtggcca     1320

aggcggaggg gagcccaact gccatcctca ttggctgcct ggtggccatc atccttctcc     1380

tcctccttat cattgccctg atgctctgga ggctgcactg gcgccggctg ctcagcaagg     1440

cagagcgccg ggtgttggag gaggagctga cggttcacct ctctgtccct ggggacacca     1500

tcctcatcaa caaccgccca gggccccgag agccaccccc ttaccaggaa ccccggcctc     1560

gggggactcc aactcactct gcgccctgcg tccccaatgg ctctgcgttg ctgctctcca     1620

atccggccta ccgcctcctt ctggccactt acgcccgtcc ccctcgaggc ccgggccccc     1680

ccacacccgc ctgggccaaa cccaccaaca cccaggcctg cagtggggac tacatggagc     1740

ccgagaagcc gggcgcccca cttctacccc cacctcccca gaacagcgtc ccccattacg     1800

ccgaggctga cattgtcacc ctgcagggcg tcacaggggg caacacctac gctgttcccg     1860

cactgccccc aggggcggtt ggggatgggc cccccagagt ggatttccct cggtcacggc     1920

tccgtttcaa ggagaagctc ggcgagggcc aatttgggga ggtacatctc tgtgaagtag     1980

aggaccctca agatctggtc actagtgact tccctatcag tgtgcaaaag ggacacccct     2040

tgctggtggc agtgaagatc ctccggccag atgccaccaa aaatgccagg aatgacttcc     2100

tgaaggaggt aaagatcatg tcacggctga aggacccaaa catcatccgg ctcctgggtg     2160

tgtgtgtgca ggatgaccct ctctgcatga ttacagacta catggagaac ggtgacctga     2220

accaattcct cagtgcccac cagctggaga acaaggtcac tcaggggctt cctggggaca     2280

gagagtctga ccaggggccc acaatcagct accctatgct gttacacgtg ggggcccaga     2340

tcgcctctgg catgcgatat ctggccaccc ttaactttgt gcatcgggac ctggccaccc     2400

ggaactgctt ggttggggaa aatttcacca tcaaaatcgc cgactttggc atgagccgga     2460

atctctacgc tggggattat taccgtgtac agggccgggc agtgctgccc atcaggtgga     2520

tggcctggga gtgtatcctc atggggaagt tcacaacagc cagtgatgtg tgggccttcg     2580

gagtgaccct gtgggaggtg cttatgctct gcaggtcaca gcccttcggg caactcacag     2640

acgagcaggt catcgagaac gccggcgagt tcttcaggga ccagggccgg caggtatact     2700

tatccaggcc acccgcctgc ccgcagacct tgtatgagct gatgctccgg tgttggagcc     2760

gggagccgga gcagcggccg cccttctccc agcttcatcg gttcctggcg gatgatgcac     2820

tcaacacagt gtaa                                                       2834


<210>  12
<211>  910
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Met Gly Thr Gly Thr Leu Ser Ser Leu Leu Leu Leu Leu Leu Leu Val 
1               5                   10                  15      


Thr Ile Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys 
            20                  25                  30          


Arg Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile 
        35                  40                  45              


Ser Val Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg 
    50                  55                  60                  


Leu Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Pro Val 
65                  70                  75                  80  


Phe Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Arg Arg Leu His 
                85                  90                  95      


Leu Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly 
            100                 105                 110         


Lys Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg 
        115                 120                 125             


Arg Trp Met Asp Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly 
    130                 135                 140                 


Asn Glu Asp Pro Gly Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met 
145                 150                 155                 160 


Val Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser 
                165                 170                 175     


Val Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu 
            180                 185                 190         


Leu Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Gln Leu Ser Glu Met 
        195                 200                 205             


Val Tyr Leu Asn Asp Ser Thr Tyr Asp Gly Tyr Thr Ala Gly Gly Leu 
    210                 215                 220                 


Gln Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp 
225                 230                 235                 240 


Asp Phe Arg Gln Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr 
                245                 250                 255     


Val Gly Trp Ser Asn His Ser Phe Pro Ser Gly Tyr Val Glu Met Glu 
            260                 265                 270         


Phe Glu Phe Asp Arg Leu Arg Ser Phe Gln Thr Met Gln Val His Cys 
        275                 280                 285             


Asn Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys 
    290                 295                 300                 


Arg Phe Lys Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Val Arg 
305                 310                 315                 320 


His Ala Leu Gly Gly Ser Leu Gly Asp Pro Arg Ala Arg Ala Ile Ser 
                325                 330                 335     


Val Pro Leu Gly Gly His Val Gly Arg Phe Leu Gln Cys Arg Phe Leu 
            340                 345                 350         


Phe Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp 
        355                 360                 365             


Val Val Asn Asp Ser Ser Asp Thr Phe Pro Pro Ala Pro Trp Trp Pro 
    370                 375                 380                 


Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu Glu Pro Arg 
385                 390                 395                 400 


Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr Ala Ile Leu 
                405                 410                 415     


Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu Ile Ile Ala 
            420                 425                 430         


Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser Lys Ala Glu 
        435                 440                 445             


Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser Val Pro Gly 
    450                 455                 460                 


Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu Pro Pro Pro 
465                 470                 475                 480 


Tyr Gln Glu Pro Arg Pro Arg Gly Thr Pro Thr His Ser Ala Pro Cys 
                485                 490                 495     


Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala Tyr Arg Leu 
            500                 505                 510         


Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly Pro Pro Thr 
        515                 520                 525             


Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Cys Ser Gly Asp Tyr 
    530                 535                 540                 


Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro Pro Pro Gln 
545                 550                 555                 560 


Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr Leu Gln Gly 
                565                 570                 575     


Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro Pro Gly Ala 
            580                 585                 590         


Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser Arg Leu Arg 
        595                 600                 605             


Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val His Leu Cys 
    610                 615                 620                 


Glu Val Glu Asp Pro Gln Asp Leu Val Thr Ser Asp Phe Pro Ile Ser 
625                 630                 635                 640 


Val Gln Lys Gly His Pro Leu Leu Val Ala Val Lys Ile Leu Arg Pro 
                645                 650                 655     


Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu Val Lys Ile 
            660                 665                 670         


Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu Gly Val Cys 
        675                 680                 685             


Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met Glu Asn Gly 
    690                 695                 700                 


Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asn Lys Val Thr 
705                 710                 715                 720 


Gln Gly Leu Pro Gly Asp Arg Glu Ser Asp Gln Gly Pro Thr Ile Ser 
                725                 730                 735     


Tyr Pro Met Leu Leu His Val Gly Ala Gln Ile Ala Ser Gly Met Arg 
            740                 745                 750         


Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn 
        755                 760                 765             


Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp Phe Gly Met 
    770                 775                 780                 


Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln Gly Arg Ala 
785                 790                 795                 800 


Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu Met Gly Lys 
                805                 810                 815     


Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu 
            820                 825                 830         


Val Leu Met Leu Cys Arg Ser Gln Pro Phe Gly Gln Leu Thr Asp Glu 
        835                 840                 845             


Gln Val Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln 
    850                 855                 860                 


Val Tyr Leu Ser Arg Pro Pro Ala Cys Pro Gln Thr Leu Tyr Glu Leu 
865                 870                 875                 880 


Met Leu Arg Cys Trp Ser Arg Glu Pro Glu Gln Arg Pro Pro Phe Ser 
                885                 890                 895     


Gln Leu His Arg Phe Leu Ala Asp Asp Ala Leu Asn Thr Val 
            900                 905                 910 


<210>  13
<211>  2742
<212>  DNA
<213>  Macaca mulatta

<400>  13
atggggccag gggccctctc gtctttactg ctgctgctct tggtggcaag tggagatgct       60

gacatgaagg gacattttga tcctgccaag tgccgctatg ccctgggcat gcaggaccgg      120

accatcccag acagtgacat ctctgcttcc agctcctggt cagactccac tgccgcccgc      180

cacagcaggt tggagagcag tgacggggat ggggcctggt gccccgcagg gtcggtgttt      240

cccaaggagg aggagtactt gcaggtggat ctacaacggc tgcacctggt ggctctggtg      300

ggcacccagg gacggcatgc tgggggcctg ggcaaggagt tctcccggag ctaccggctg      360

cgttactccc gggacggtcg ccgctggatg gactggaagg accgctgggg tcaggaggtg      420

atctcaggca atgaggaccc tgagggagta gtgctgaagg accttgggcc ccccatggtt      480

gcccgactgg ttcgcttcta cccccgggct gaccgggtca tgagcgtctg tctgcgggtg      540

gagctctatg gctgcctctg gagggatgga ctcctgtctt acaccgcccc tgtggggcag      600

acaatgtact tatctgaggc tgtgtacctc aacgactcca cctatgatgg acataccatg      660

ggcggattgc agtatggggg tctgggccag ctggcagatg gcgtggtggg gctggatgac      720

tttaggaaga gtcaggagct acgggtctgg ccaggctatg actatgtggg atggagcaac      780

cacagcttct ccagtggcta cgtggagatg gagtttgagt ttgaccggct gagggccttc      840

caggccatgc aggtccactg taacaacatg cacacgctgg gagcccgtct gcctggcggg      900

gtggaatgtc gcttccggcg tggccctgcc atggcctggg agggggagcc tatgcgccac      960

aacctggggg gcaacctggg ggaccccaga gcccgggctg tctcagtgcc ccttggtggc     1020

cgtgtagctc gctttctgca gtgccgcttc ctctttgcgg ggccctggtt actcttcagc     1080

gaaatctcct tcatctctga tgtggtgaac aattcctctc cggcactggg aggcaccttc     1140

ccaccagccc cctggtggcc gcctggccca cctcccacca acttcagcag cttggagctg     1200

gagcccaggg gccagcagcc cgtggccaag gccgagggga gcccgaccgc aatcctcatc     1260

ggctgcctgg tggccatcat cctgctcctg ctgctcatca ttgccctcat gctctggcgg     1320

ctgcactggc gtaggctcct cagcaaggct gaacggaggg tgttggaaga ggagctgacg     1380

gttcacctct ctgttcctgg ggacactatc ctcatcaaca accgcccagg tcctagagag     1440

ccacccccct accaggagcc ccggcctcgt gggaatccgc cccactccgc tccctgtgtc     1500

cccaatggct ctgcgttgct gctctccaat ccagcctacc gcctccttct ggccacttac     1560

gcccgtcccc ctcgaggccc gggccccccc acacccacct gggccaaacc caccaacacc     1620

caggcctaca gtggggacta tatggagcct gagaagccag gcgccccgct tctgccccca     1680

cctccccaga acagcgtccc ccattatgcc gaggctgaca ttgttaccct gcagggcgtc     1740

accgggggca acacctatgc tgtgcctgca ctgcccccag gggcagttgg ggatgggccc     1800

cccagagtgg atttccctcg atcgaggctc cgcttcaaag agaagcttgg cgagggccag     1860

tttggggagg tgcacctgtg tgaggtcgac agccctcaag atctggtcag tcttgactgc     1920

ccccttaata tgcgtaaggg acaccccttg ctggtagctg tcaagatctt acggccagat     1980

gccaccaaga atgccaggaa tgatttcctg aaagaggtga agatcatgtc gaggctcaag     2040

gacccaaaca tcatccggct gctgggcgtg tgtgtgcagg acgaccccct ctgcatgatt     2100

actgactaca tggagaacgg cgacctcaac cagttcctca gcgcccacca gctggaggac     2160

aaggcagctg agggggcccc tggggatggg caggctgcgc aggggcccac catcagctac     2220

ccaatgctgt tgcatgtggc agcccagatc gcctccggca tgcgctatct ggccacactc     2280

aactttgtac atcgcgacct ggccacgcgg aactgcctag ttggggaaaa tttcaccatc     2340

aaaatcgcag actttggcat gagccggaac ctctatgctg gggactatta ccgtgtgcag     2400

ggccgggcag tgctgcccat ccgctggatg gcctgggagt gcatcctcat ggggaagttc     2460

acgactgcga gtgatgtgtg ggcctttggc gtgaccctgt gggaggtgct gatgctctgc     2520

agggcccagc cctttgggca gctcaccgac gagcaggtca tcgagaacgc gggggagttc     2580

ttccgggacc agggccggca ggtgtacctg tcccggccgc ctgcctgccc gcagggccta     2640

tatgagctga tgcttcggtg ctggagccgg gagtctgagc agcgaccacc cttttcccag     2700

ctgcatcggt tcctggcaga ggatgccctc aacacggtgt ga                        2742


<210>  14
<211>  913
<212>  PRT
<213>  Macaca mulatta

<400>  14

Met Gly Pro Gly Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Asp Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Met Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala 
            500                 505                 510         


Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly 
        515                 520                 525             


Pro Pro Thr Pro Thr Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser 
    530                 535                 540                 


Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro 
545                 550                 555                 560 


Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr 
                565                 570                 575     


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro 
            580                 585                 590         


Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser 
        595                 600                 605             


Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val 
    610                 615                 620                 


His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Cys 
625                 630                 635                 640 


Pro Leu Asn Met Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile 
                645                 650                 655     


Leu Arg Pro Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu 
            660                 665                 670         


Val Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu 
        675                 680                 685             


Gly Val Cys Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met 
    690                 695                 700                 


Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp 
705                 710                 715                 720 


Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro 
                725                 730                 735     


Thr Ile Ser Tyr Pro Met Leu Leu His Val Ala Ala Gln Ile Ala Ser 
            740                 745                 750         


Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala 
        755                 760                 765             


Thr Arg Asn Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp 
    770                 775                 780                 


Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln 
785                 790                 795                 800 


Gly Arg Ala Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu 
                805                 810                 815     


Met Gly Lys Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr 
            820                 825                 830         


Leu Trp Glu Val Leu Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu 
        835                 840                 845             


Thr Asp Glu Gln Val Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln 
    850                 855                 860                 


Gly Arg Gln Val Tyr Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu 
865                 870                 875                 880 


Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro 
                885                 890                 895     


Pro Phe Ser Gln Leu His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr 
            900                 905                 910         


Val 
    


