                         SEQUENCE LISTING

<110>  Ferrumax Pharmaceuticals, Inc.
       The General Hospital Corporation
       Lin, Herb
       Menhall, Tracey
       Babitt, Jodie
       Gearing, Patrick
 
<120>  COMPOSITIONS FOR REGULATING IRON HOMEOSTASIS AND METHODS OF USING SAME

<130>  523702 FPC-001PC

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Cys Lys Ile Leu Arg Cys Asn Ala Glu Tyr Val Ser Ser Thr Leu 
1               5                   10                  15      


Ser Leu Arg Gly Gly Gly Ser Ser Gly Ala Leu Arg Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Arg Gly Gly Gly Val Gly Ser Gly Gly Leu Cys Arg Ala Leu 
        35                  40                  45              


Arg Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly 
    50                  55                  60                  


Asp Leu Ala Phe His Ser Ala Val His Gly Ile Glu Asp Leu Met Ile 
65                  70                  75                  80  


Gln His Asn Cys Ser Arg Gln Gly Pro Thr Ala Pro Pro Pro Pro Arg 
                85                  90                  95      


Gly Pro Ala Leu Pro Gly Ala Gly Ser Gly Leu Pro Ala Pro Asp Pro 
            100                 105                 110         


Cys Asp Tyr Glu Gly Arg Phe Ser Arg Leu His Gly Arg Pro Pro Gly 
        115                 120                 125             


Phe Leu His Cys Ala Ser Phe Gly Asp Pro His Val Arg Ser Phe His 
    130                 135                 140                 


His His Phe His Thr Cys Arg Val Gln Gly Ala Trp Pro Leu Leu Asp 
145                 150                 155                 160 


Asn Asp Phe Leu Phe Val Gln Ala Thr Ser Ser Pro Met Ala Leu Gly 
                165                 170                 175     


Ala Asn Ala Thr Ala Thr Arg Lys Leu Thr Ile Ile Phe Lys Asn Met 
            180                 185                 190         


Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val Asp Asn Leu 
        195                 200                 205             


Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp Arg Pro Gly 
    210                 215                 220                 


Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn His Val Glu 
225                 230                 235                 240 


Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg Gln Thr Ala 
                245                 250                 255     


Gly Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val Ala Met Ala 
            260                 265                 270         


Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly Cys Pro Pro 
        275                 280                 285             


Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly Ala Ile Thr 
    290                 295                 300                 


Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro Val Glu Asp 
305                 310                 315                 320 


Ala Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser Gly Asp Pro 
                325                 330                 335     


Asn Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala Arg Ala Phe 
            340                 345                 350         


Leu Pro Asp Leu Glu Lys Leu His 
        355                 360 


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge region.


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Cys or Ser.

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Leu or Pro.

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is Cys or Ser.

<400>  2

Xaa Pro Xaa Xaa 
1               


<210>  3
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG Fc derivative.

<400>  3

Asp Pro Lys Ser Cys Asp Lys Pro His Thr Cys Pro Leu Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Ala Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  4
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  5
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc region from VEGF-R Fc fusion.

<400>  5

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  6
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc region from CTLA4 Fc fusion.

<400>  6

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  7
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc region from IL-1R Fc fusion.

<400>  7

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker.

<400>  8

Gly Gly Gly Gly Gly 
1               5   


<210>  9
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HJV.Fc fusion.

<400>  9

Gln Cys Lys Ile Leu Arg Cys Asn Ala Glu Tyr Val Ser Ser Thr Leu 
1               5                   10                  15      


Ser Leu Arg Gly Gly Gly Ser Ser Gly Ala Leu Arg Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Arg Gly Gly Gly Val Gly Ser Gly Gly Leu Cys Arg Ala Leu 
        35                  40                  45              


Arg Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly 
    50                  55                  60                  


Asp Leu Ala Phe His Ser Ala Val His Gly Ile Glu Asp Leu Met Ile 
65                  70                  75                  80  


Gln His Asn Cys Ser Arg Gln Gly Pro Thr Ala Pro Pro Pro Pro Arg 
                85                  90                  95      


Gly Pro Ala Leu Pro Gly Ala Gly Ser Gly Leu Pro Ala Pro Asp Pro 
            100                 105                 110         


Cys Asp Tyr Glu Gly Arg Phe Ser Arg Leu His Gly Arg Pro Pro Gly 
        115                 120                 125             


Phe Leu His Cys Ala Ser Phe Gly Asp Pro His Val Arg Ser Phe His 
    130                 135                 140                 


His His Phe His Thr Cys Arg Val Gln Gly Ala Trp Pro Leu Leu Asp 
145                 150                 155                 160 


Asn Asp Phe Leu Phe Val Gln Ala Thr Ser Ser Pro Met Ala Leu Gly 
                165                 170                 175     


Ala Asn Ala Thr Ala Thr Arg Lys Leu Thr Ile Ile Phe Lys Asn Met 
            180                 185                 190         


Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val Asp Asn Leu 
        195                 200                 205             


Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp Arg Pro Gly 
    210                 215                 220                 


Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn His Val Glu 
225                 230                 235                 240 


Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg Gln Thr Ala 
                245                 250                 255     


Gly Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val Ala Met Ala 
            260                 265                 270         


Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly Cys Pro Pro 
        275                 280                 285             


Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly Ala Ile Thr 
    290                 295                 300                 


Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro Val Glu Asp 
305                 310                 315                 320 


Ala Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser Gly Asp Pro 
                325                 330                 335     


Asn Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala Arg Ala Phe 
            340                 345                 350         


Leu Pro Asp Leu Glu Lys Leu His Leu Phe Pro Ser Asp Pro Lys Ser 
        355                 360                 365             


Cys Asp Lys Pro His Thr Cys Pro Leu Cys Pro Ala Pro Glu Leu Leu 
    370                 375                 380                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
385                 390                 395                 400 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                405                 410                 415     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            420                 425                 430         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        435                 440                 445             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    450                 455                 460                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
465                 470                 475                 480 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                485                 490                 495     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            500                 505                 510         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        515                 520                 525             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Ala Thr Pro 
    530                 535                 540                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
545                 550                 555                 560 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                565                 570                 575     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            580                 585                 590         


Ser Pro Gly Lys 
        595     


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminus of fusion protein.

<400>  10

Gln Cys Lys Ile Leu Arg Cys Asn Ala Glu 
1               5                   10  


<210>  11
<211>  5638
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Encodes HJV.Fc fusion.

<400>  11
ttctagagaa tccagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa       60

tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca      120

ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc      180

agggggaggt gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtatggctg      240

attatgatca atcgatgtcg accaattcgt aatcatgtca tagctgtttc ctgtgtgaaa      300

ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt gtaaagcctg      360

gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcca      420

gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg      480

tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg      540

gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg      600

ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa      660

ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg      720

acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc      780

tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc      840

ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc      900

ggtgtaggtc gttcgctcca agctgggctg tgagcacgaa ccccccgttc agcccgaccg      960

ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc     1020

actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga     1080

gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc     1140

tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac     1200

caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg     1260

atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc     1320

acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa     1380

ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta     1440

ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt     1500

tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag     1560

tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag caataaacca     1620

gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc     1680

tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt     1740

tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag     1800

ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt     1860

tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat     1920

ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt     1980

gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc     2040

ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat     2100

cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag     2160

ttcgatgtaa cccactcgcg cacccaactg atcttcagca tcttttactt tcaccagcgt     2220

ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg     2280

gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta     2340

ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc     2400

gcgcacattt ccccgaaaag tgccacctga cgtctaagaa accattatta tcatgacatt     2460

aacctataaa aataggcgta tcacgaggcc ctttcgtctc gcgcgtttcg gtgatgacgg     2520

tgaaaacctc tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc     2580

cgggagcaga caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc ggggctggct     2640

taactatgcg gcatcagagc agattgtact gagagcgcac catatgcggt gtgaaatacc     2700

gcacagatgc gtaaggagaa aataccgcat caggcgccat tcgccattca ggctgcgcaa     2760

ctgttgggaa gggcgatcgg tgcgggcctc ttcgctatta cgccagctgg cgaaaggggg     2820

atgtgctgca aggcgattaa gttgggtaac gccagggttt tcccagtcac gacgttgtaa     2880

aacgacggcc agtgccaagc tagcggccgc cacgagtcta gctagagtac gaattcgagc     2940

tcggaacccc tatacattga atcaatattg gcaattagcc atattagtca ttggttatat     3000

agcataaatc aatattggct attggccatt gcatacgttg tatctatatc ataatatgta     3060

catttatatt ggctcatgtc caatatgacc gccatgttga cattgattat tgactagtta     3120

ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac     3180

ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc     3240

aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt     3300

ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc     3360

gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac     3420

cttacgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt     3480

gatgcggttt tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc     3540

aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt     3600

tccaaaatgt cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg     3660

ggaggtctat ataagcagag ctcgtttagt gaaccgtcag atcggggatc cgatatccac     3720

catgggggag ccaggccagt cccctagtcc caggtcctcc catggcagtc ccccaactct     3780

aagcactctc actctcctgc tgctcctctg tggacatgct cattctcaat gcaagatcct     3840

ccgctgcaat gctgagtacg tatcgtccac tctgagcctt agaggtgggg gttcatcagg     3900

agcacttcga ggaggaggag gaggaggccg gggtggaggg gtgggctctg gcggcctctg     3960

tcgagccctc cgctcctatg cgctctgcac tcggcgcacc gcccgcacct gccgcgggga     4020

cctcgccttc cattcggcgg tacatggcat cgaagacctg atgatccagc acaactgctc     4080

ccgccagggc cctacagccc ctcccccgcc ccggggcccc gcccttccag gcgcgggctc     4140

cggcctccct gccccggacc cttgtgacta tgaaggccgg ttttcccggc tgcatggtcg     4200

tcccccgggg ttcttgcatt gcgcttcctt cggggacccc catgtgcgca gcttccacca     4260

tcactttcac acatgccgtg tccaaggagc ttggcctcta ctggataatg acttcctctt     4320

tgtccaagcc accagctccc ccatggcgtt gggggccaac gctaccgcca cccggaagct     4380

caccatcata tttaagaaca tgcaggaatg cattgatcag aaggtgtatc aggctgaggt     4440

ggataatctt cctgtagcct ttgaagatgg ttctatcaat ggaggtgacc gacctggggg     4500

atccagtttg tcgattcaaa ctgctaaccc tgggaaccat gtggagatcc aagctgccta     4560

cattggcaca actataatca ttcggcagac agctgggcag ctctccttct ccatcaaggt     4620

agcagaggat gtggccatgg ccttctcagc tgaacaggac ctgcagctct gtgttggggg     4680

gtgccctcca agtcagcgac tctctcgatc agagcgcaat cgtcggggag ctataaccat     4740

tgatactgcc agacggctgt gcaaggaagg gcttccagtg gaagatgctt acttccattc     4800

ctgtgtcttt gatgttttaa tttctggtga tcccaacttt accgtggcag ctcaggcagc     4860

actggaggat gcccgagcct tcctgccaga cttagagaag ctgcatctct tcccctcagg     4920

tggtggtggt ggtgatccca aatcttgtga caaacctcac acatgcccac tgtgcccagc     4980

acctgaactc ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct     5040

catgatctcc cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc     5100

tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc     5160

gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca     5220

ggactggctg aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc     5280

catcgagaaa accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct     5340

gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tagtcaaagg     5400

cttctatccc agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta     5460

caaggccacg cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac     5520

cgtggacaag agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc     5580

tctgcacaac cactacacgc agaagagcct ctccctgtct ccgggtaaat gagctgat       5638


