                         SEQUENCE LISTING

<110>  Applied Informatic Solutions, Inc.
 
<120>  KITS AND METHODS FOR SELECTING A TREATMENT FOR OVARIAN CANCER

<130>  17002.0002WOU1

<140>  New Filing
<141>  2012-05-02

<150>  US 61/481,556
<151>  2011-05-02

<160>  38    

<170>  PatentIn version 3.3

<210>  1
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Cys Gly Asn Thr Met Ser Val Pro Leu Leu Thr Asp Ala Ala Thr 
1               5                   10                  15      


Val Ser Gly Ala Glu Arg Glu Thr Ala Ala Val Ile Phe Leu His Gly 
            20                  25                  30          


Leu Gly Asp Thr Gly His Ser Trp Ala Asp Ala Leu Ser Thr Ile Arg 
        35                  40                  45              


Leu Pro His Val Lys Tyr Ile Cys Pro His Ala Pro Arg Ile Pro Val 
    50                  55                  60                  


Thr Leu Asn Met Lys Met Val Met Pro Ser Trp Phe Asp Leu Met Gly 
65                  70                  75                  80  


Leu Ser Pro Asp Ala Pro Glu Asp Glu Ala Gly Ile Lys Lys Ala Ala 
                85                  90                  95      


Glu Asn Ile Lys Ala Leu Ile Glu His Glu Met Lys Asn Gly Ile Pro 
            100                 105                 110         


Ala Asn Arg Ile Val Leu Gly Gly Phe Ser Gln Gly Gly Ala Leu Ser 
        115                 120                 125             


Leu Tyr Thr Ala Leu Thr Cys Pro His Pro Leu Ala Gly Ile Val Ala 
    130                 135                 140                 


Leu Ser Cys Trp Leu Pro Leu His Arg Ala Phe Pro Gln Ala Ala Asn 
145                 150                 155                 160 


Gly Ser Ala Lys Asp Leu Ala Ile Leu Gln Cys His Gly Glu Leu Asp 
                165                 170                 175     


Pro Met Val Pro Val Arg Phe Gly Ala Leu Thr Ala Glu Lys Leu Arg 
            180                 185                 190         


Ser Val Val Thr Pro Ala Arg Val Gln Phe Lys Thr Tyr Pro Gly Val 
        195                 200                 205             


Met His Ser Ser Cys Pro Gln Glu Met Ala Ala Val Lys Glu Phe Leu 
    210                 215                 220                 


Glu Lys Leu Leu Pro Pro Val 
225                 230     


<210>  2
<211>  1648
<212>  DNA
<213>  Homo sapiens

<400>  2
ggaagttccg gcgggggcgg ccgaggggga agagtgtgtc tgcgggagaa agaggagaat     60

cgcccaagcg gcctcggaag tcccagggag tggaggcccc cgccgtggag ccgtgtggtg    120

tatgtgtggt aacaccatgt ctgtgcccct gctcaccgat gctgccaccg tgtctggagc    180

tgagcgggaa acggccgcgg ttattttttt acatggactt ggagacacag ggcacagctg    240

ggctgacgcc ctctccacca tccggctccc tcacgtcaag tacatctgtc cccatgcgcc    300

taggatccct gtgaccctca acatgaagat ggtgatgccc tcctggtttg acctgatggg    360

gctgagtcca gatgccccag aggacgaggc tggcatcaag aaggcagcag agaacatcaa    420

ggccttgatt gagcatgaaa tgaagaacgg gatccctgcc aatcgaatcg tcctgggagg    480

cttttcacag ggcggggccc tgtccctcta cacggccctc acctgccccc accctctggc    540

tggcatcgtg gcgttgagct gctggctgcc tctgcaccgg gccttccccc aggcagctaa    600

tggcagtgcc aaggacctgg ccatactcca gtgccatggg gagctggacc ccatggtgcc    660

cgtacggttt ggggccctga cggctgagaa gctccggtct gttgtcacac ctgccagggt    720

ccagttcaag acatacccgg gtgtcatgca cagctcctgt cctcaggaga tggcagctgt    780

gaaggaattt cttgagaagc tgctgcctcc tgtctaacta gtcgctggcc ccagtgcagt    840

accccagctc atgggggact cagcaagcaa gcgtggcacc atcttggatc tgagccggtc    900

gagcccctgt ccccaccctt cctgacctgt ccttttccca caggcctctg ggggcaggtg    960

gcaaggcctg gccgggcctt ccttcctggc cttagccacc tggctctgtc tgcagcaggg   1020

gcaggctgct ttcttatcca tttccctgga ggcgggcccc cctggcagca gtattggagg   1080

ggctacaggc agctggagaa aggggcccag ccgctgaccc actcactcag gacctcactc   1140

actagccccg ctttgggccc cctcctgtga cctcagggtt tggcccatgg ggccccccca   1200

ggcccctgcc ccaactgatt ctgcccagat aatcgtgtct cctgcctcca ctcagctgct   1260

tctcagtcat gaatgtggcc atggccccgg ggtccccttg ctgctgtggg ctccctgtcc   1320

ctgggcagga gtgctggtga ggaggtggag ccttttgagg ggggccttcc ctcagctgtt   1380

tccccacact ggggggctgg gccctgcctc cccgttaccc tccttccctg caggcctgga   1440

gcctgtaggg ctggactgag gttcaggtct ccccccagct gtctcacccc cactttgtcc   1500

ccactctaga gcagggaggc agtgggggag gagttgtgtc tcgtcttctg tctccatgtg   1560

gtttttgggt gtttttcttg ttgtgtcctg gattccgata aaattaaaga aattgcttcc   1620

tcaaaaaaaa aaaaaaaaaa aaaaaaaa                                      1648


<210>  3
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Val Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Val Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Leu 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Ile Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Ala Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ala Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Met Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Leu Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Val Asp Ser Val Glu Ala Glu Ala Glu Glu Gly Glu 
        435                 440                 445             


Glu Tyr 
    450 


<210>  4
<211>  1504
<212>  DNA
<213>  Homo sapiens

<400>  4
ggttgaggtc aagtagtagc gttgggctgc ggcagcggag gagctcaaca tgcgtgagtg     60

tatctctatc cacgtggggc aggcaggagt ccagatcggc aatgcctgct gggaactgta    120

ctgcctggaa catggaattc agcccgatgg tcagatgcca agtgataaaa ccattggtgg    180

tggggacgac tccttcaaca cgttcttcag tgagactgga gctggcaagc acgtgcccag    240

agcagtgttt gtggacctgg agcccactgt ggtcgatgaa gtgcgcacag gaacctatag    300

gcagctcttc cacccagagc agctgatcac cgggaaggaa gatgcggcca ataattacgc    360

cagaggccat tacaccatcg gcaaggagat cgtcgacctg gtcctggacc ggatccgcaa    420

actggcggat ctgtgcacgg gactgcaggg cttcctcatc ttccacagtt ttgggggtgg    480

cactggctct gggttcgcat ctctgctcat ggagcggctc tcagtggatt acggcaagaa    540

gtccaagcta gaatttgcca tttacccagc cccccaggtc tccacggccg tggtggagcc    600

ctacaactcc atcctgacca cccacacgac cctggaacat tctgactgtg ccttcatggt    660

cgacaatgaa gccatctatg acatatgtcg gcgcaacctg gacatcgagc gtcccacgta    720

caccaacctc aatcgcctga ttgggcagat cgtgtcctcc atcacggcct ccctgcgatt    780

tgacggggcc ctgaatgtgg acttgacgga attccagacc aacctagtgc cgtacccccg    840

catccacttc cccctggcca cctacgcccc ggtcatctca gccgagaagg cctaccacga    900

gcagctgtcc gtggctgaga tcaccaatgc ctgcttcgag ccagccaatc agatggtcaa    960

gtgtgaccct cgccacggca agtacatggc ctgctgcatg ttgtacaggg gggatgtggt   1020

cccgaaagat gtcaacgcgg ccatcgccac catcaagacc aagcgcacca tccagtttgt   1080

agattggtgc ccaactggat ttaaggtggg cattaactac cagcccccca cggtggtccc   1140

tgggggagac ctggccaagg tgcagcgggc tgtgtgcatg ctgagcaaca ccacggccat   1200

cgcggaggcc tgggctcgcc tggaccataa gttcgatctc atgtatgcca agcgggcctt   1260

tgtgcactgg tacgtgggag aaggcatgga ggagggggag ttctctgagg cccgcgagga   1320

cctggcagct ctggagaagg attatgaaga ggtgggcgtg gattccgtgg aagccgaggc   1380

tgaagaaggt gaagaatact gaggggaggg tgtggtgggt tctccactcc actgccaccc   1440

ccagcgtggc tgctttcaag ttctttgcaa ttaaaggttc tgtataaaaa aaaaaaaaaa   1500

aaaa                                                                1504


<210>  5
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  6
<211>  1852
<212>  DNA
<213>  Homo sapiens

<400>  6
accgccgaga ccgcgtccgc cccgcgagca cagagcctcg cctttgccga tccgccgccc     60

gtccacaccc gccgccagct caccatggat gatgatatcg ccgcgctcgt cgtcgacaac    120

ggctccggca tgtgcaaggc cggcttcgcg ggcgacgatg ccccccgggc cgtcttcccc    180

tccatcgtgg ggcgccccag gcaccagggc gtgatggtgg gcatgggtca gaaggattcc    240

tatgtgggcg acgaggccca gagcaagaga ggcatcctca ccctgaagta ccccatcgag    300

cacggcatcg tcaccaactg ggacgacatg gagaaaatct ggcaccacac cttctacaat    360

gagctgcgtg tggctcccga ggagcacccc gtgctgctga ccgaggcccc cctgaacccc    420

aaggccaacc gcgagaagat gacccagatc atgtttgaga ccttcaacac cccagccatg    480

tacgttgcta tccaggctgt gctatccctg tacgcctctg gccgtaccac tggcatcgtg    540

atggactccg gtgacggggt cacccacact gtgcccatct acgaggggta tgccctcccc    600

catgccatcc tgcgtctgga cctggctggc cgggacctga ctgactacct catgaagatc    660

ctcaccgagc gcggctacag cttcaccacc acggccgagc gggaaatcgt gcgtgacatt    720

aaggagaagc tgtgctacgt cgccctggac ttcgagcaag agatggccac ggctgcttcc    780

agctcctccc tggagaagag ctacgagctg cctgacggcc aggtcatcac cattggcaat    840

gagcggttcc gctgccctga ggcactcttc cagccttcct tcctgggcat ggagtcctgt    900

ggcatccacg aaactacctt caactccatc atgaagtgtg acgtggacat ccgcaaagac    960

ctgtacgcca acacagtgct gtctggcggc accaccatgt accctggcat tgccgacagg   1020

atgcagaagg agatcactgc cctggcaccc agcacaatga agatcaagat cattgctcct   1080

cctgagcgca agtactccgt gtggatcggc ggctccatcc tggcctcgct gtccaccttc   1140

cagcagatgt ggatcagcaa gcaggagtat gacgagtccg gcccctccat cgtccaccgc   1200

aaatgcttct aggcggacta tgacttagtt gcgttacacc ctttcttgac aaaacctaac   1260

ttgcgcagaa aacaagatga gattggcatg gctttatttg ttttttttgt tttgttttgg   1320

tttttttttt ttttttggct tgactcagga tttaaaaact ggaacggtga aggtgacagc   1380

agtcggttgg agcgagcatc ccccaaagtt cacaatgtgg ccgaggactt tgattgcaca   1440

ttgttgtttt tttaatagtc attccaaata tgagatgcgt tgttacagga agtcccttgc   1500

catcctaaaa gccaccccac ttctctctaa ggagaatggc ccagtcctct cccaagtcca   1560

cacaggggag gtgatagcat tgctttcgtg taaattatgt aatgcaaaat ttttttaatc   1620

ttcgccttaa tactttttta ttttgtttta ttttgaatga tgagccttcg tgccccccct   1680

tccccctttt ttgtccccca acttgagatg tatgaaggct tttggtctcc ctgggagtgg   1740

gtggaggcag ccagggctta cctgtacact gacttgagac cagttgaata aaagtgcaca   1800

ccttaaaaat gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa           1852


<210>  7
<211>  2210
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Thr Ala Ala Ala Asn Trp Val Ala Asn Gly Ala Ser Leu Glu Asp 
1               5                   10                  15      


Cys His Ser Asn Leu Phe Ser Leu Ala Glu Leu Thr Gly Ile Lys Trp 
            20                  25                  30          


Arg Arg Tyr Asn Phe Gly Gly His Gly Asp Cys Gly Pro Ile Ile Ser 
        35                  40                  45              


Ala Pro Ala Gln Asp Asp Pro Ile Leu Leu Ser Phe Ile Arg Cys Leu 
    50                  55                  60                  


Gln Ala Asn Leu Leu Cys Val Trp Arg Arg Asp Val Lys Pro Asp Cys 
65                  70                  75                  80  


Lys Glu Leu Trp Ile Phe Trp Trp Gly Asp Glu Pro Asn Leu Val Gly 
                85                  90                  95      


Val Ile His His Glu Leu Gln Val Val Glu Glu Gly Leu Trp Glu Asn 
            100                 105                 110         


Gly Leu Ser Tyr Glu Cys Arg Thr Leu Leu Phe Lys Ala Ile His Asn 
        115                 120                 125             


Leu Leu Glu Arg Cys Leu Met Asp Lys Asn Phe Val Arg Ile Gly Lys 
    130                 135                 140                 


Trp Phe Val Arg Pro Tyr Glu Lys Asp Glu Lys Pro Val Asn Lys Ser 
145                 150                 155                 160 


Glu His Leu Ser Cys Ala Phe Thr Phe Phe Leu His Gly Glu Ser Asn 
                165                 170                 175     


Val Cys Thr Ser Val Glu Ile Ala Gln His Gln Pro Ile Tyr Leu Ile 
            180                 185                 190         


Asn Glu Glu His Ile His Met Ala Gln Ser Ser Pro Ala Pro Phe Gln 
        195                 200                 205             


Val Leu Val Ser Pro Tyr Gly Leu Asn Gly Thr Leu Thr Gly Gln Ala 
    210                 215                 220                 


Tyr Lys Met Ser Asp Pro Ala Thr Arg Lys Leu Ile Glu Glu Trp Gln 
225                 230                 235                 240 


Tyr Phe Tyr Pro Met Val Leu Lys Lys Lys Glu Glu Ser Lys Glu Glu 
                245                 250                 255     


Asp Glu Leu Gly Tyr Asp Asp Asp Phe Pro Val Ala Val Glu Val Ile 
            260                 265                 270         


Val Gly Gly Val Arg Met Val Tyr Pro Ser Ala Phe Val Leu Ile Ser 
        275                 280                 285             


Gln Asn Asp Ile Pro Val Pro Gln Ser Val Ala Ser Ala Gly Gly His 
    290                 295                 300                 


Ile Ala Val Gly Gln Gln Gly Leu Gly Ser Val Lys Asp Pro Ser Asn 
305                 310                 315                 320 


Cys Gly Met Pro Leu Thr Pro Pro Thr Ser Pro Glu Gln Ala Ile Leu 
                325                 330                 335     


Gly Glu Ser Gly Gly Met Gln Ser Ala Ala Ser His Leu Val Ser Gln 
            340                 345                 350         


Asp Gly Gly Met Ile Thr Met His Ser Pro Lys Arg Ser Gly Lys Ile 
        355                 360                 365             


Pro Pro Lys Leu His Asn His Met Val His Arg Val Trp Lys Glu Cys 
    370                 375                 380                 


Ile Leu Asn Arg Thr Gln Ser Lys Arg Ser Gln Met Ser Thr Pro Thr 
385                 390                 395                 400 


Leu Glu Glu Glu Pro Ala Ser Asn Pro Ala Thr Trp Asp Phe Val Asp 
                405                 410                 415     


Pro Thr Gln Arg Val Ser Cys Ser Cys Ser Arg His Lys Leu Leu Lys 
            420                 425                 430         


Arg Cys Ala Val Gly Pro Asn Arg Pro Pro Thr Val Ser Gln Pro Gly 
        435                 440                 445             


Phe Ser Ala Gly Pro Ser Ser Ser Ser Ser Leu Pro Pro Pro Ala Ser 
    450                 455                 460                 


Ser Lys His Lys Thr Ala Glu Arg Gln Glu Lys Gly Asp Lys Leu Gln 
465                 470                 475                 480 


Lys Arg Pro Leu Ile Pro Phe His His Arg Pro Ser Val Ala Glu Glu 
                485                 490                 495     


Leu Cys Met Glu Gln Asp Thr Pro Gly Gln Lys Leu Gly Leu Ala Gly 
            500                 505                 510         


Ile Asp Ser Ser Leu Glu Val Ser Ser Ser Arg Lys Tyr Asp Lys Gln 
        515                 520                 525             


Met Ala Val Pro Ser Arg Asn Thr Ser Lys Gln Met Asn Leu Asn Pro 
    530                 535                 540                 


Met Asp Ser Pro His Ser Pro Ile Ser Pro Leu Pro Pro Thr Leu Ser 
545                 550                 555                 560 


Pro Gln Pro Arg Gly Gln Glu Thr Glu Ser Leu Asp Pro Pro Ser Val 
                565                 570                 575     


Pro Val Asn Pro Ala Leu Tyr Gly Asn Gly Leu Glu Leu Gln Gln Leu 
            580                 585                 590         


Ser Thr Leu Asp Asp Arg Thr Val Leu Val Gly Gln Arg Leu Pro Leu 
        595                 600                 605             


Met Ala Glu Val Ser Glu Thr Ala Leu Tyr Cys Gly Ile Arg Pro Ser 
    610                 615                 620                 


Asn Pro Glu Ser Ser Glu Lys Trp Trp His Ser Tyr Arg Leu Pro Pro 
625                 630                 635                 640 


Ser Asp Asp Ala Glu Phe Arg Pro Pro Glu Leu Gln Gly Glu Arg Cys 
                645                 650                 655     


Asp Ala Lys Met Glu Val Asn Ser Glu Ser Thr Ala Leu Gln Arg Leu 
            660                 665                 670         


Leu Ala Gln Pro Asn Lys Arg Phe Lys Ile Trp Gln Asp Lys Gln Pro 
        675                 680                 685             


Gln Leu Gln Pro Leu His Phe Leu Asp Pro Leu Pro Leu Ser Gln Gln 
    690                 695                 700                 


Pro Gly Asp Ser Leu Gly Glu Val Asn Asp Pro Tyr Thr Phe Glu Asp 
705                 710                 715                 720 


Gly Asp Ile Lys Tyr Ile Phe Thr Ala Asn Lys Lys Cys Lys Gln Gly 
                725                 730                 735     


Thr Glu Lys Asp Ser Leu Lys Lys Asn Lys Ser Glu Asp Gly Phe Gly 
            740                 745                 750         


Thr Lys Asp Val Thr Thr Pro Gly His Ser Thr Pro Val Pro Asp Gly 
        755                 760                 765             


Lys Asn Ala Met Ser Ile Phe Ser Ser Ala Thr Lys Thr Asp Val Arg 
    770                 775                 780                 


Gln Asp Asn Ala Ala Gly Arg Ala Gly Ser Ser Ser Leu Thr Gln Val 
785                 790                 795                 800 


Thr Asp Leu Ala Pro Ser Leu His Asp Leu Asp Asn Ile Phe Asp Asn 
                805                 810                 815     


Ser Asp Asp Asp Glu Leu Gly Ala Val Ser Pro Ala Leu Arg Ser Ser 
            820                 825                 830         


Lys Met Pro Ala Val Gly Thr Glu Asp Arg Pro Leu Gly Lys Asp Gly 
        835                 840                 845             


Arg Ala Ala Val Pro Tyr Pro Pro Thr Val Ala Asp Leu Gln Arg Met 
    850                 855                 860                 


Phe Pro Thr Pro Pro Ser Leu Glu Gln His Pro Ala Phe Ser Pro Val 
865                 870                 875                 880 


Met Asn Tyr Lys Asp Gly Ile Ser Ser Glu Thr Val Thr Ala Leu Gly 
                885                 890                 895     


Met Met Glu Ser Pro Met Val Ser Met Val Ser Thr Gln Leu Thr Glu 
            900                 905                 910         


Phe Lys Met Glu Val Glu Asp Gly Leu Gly Ser Pro Lys Pro Glu Glu 
        915                 920                 925             


Ile Lys Asp Phe Ser Tyr Val His Lys Val Pro Ser Phe Gln Pro Phe 
    930                 935                 940                 


Val Gly Ser Ser Met Phe Ala Pro Leu Lys Met Leu Pro Ser His Cys 
945                 950                 955                 960 


Leu Leu Pro Leu Lys Ile Pro Asp Ala Cys Leu Phe Arg Pro Ser Trp 
                965                 970                 975     


Ala Ile Pro Pro Lys Ile Glu Gln Leu Pro Met Pro Pro Ala Ala Thr 
            980                 985                 990         


Phe Ile Arg Asp Gly Tyr Asn Asn  Val Pro Ser Val Gly  Ser Leu Ala 
        995                 1000                 1005             


Asp Pro  Asp Tyr Leu Asn Thr  Pro Gln Met Asn Thr  Pro Val Thr 
    1010                 1015                 1020             


Leu Asn  Ser Ala Ala Pro Ala  Ser Asn Ser Gly Ala  Gly Val Leu 
    1025                 1030                 1035             


Pro Ser  Pro Ala Thr Pro Arg  Phe Ser Val Pro Thr  Pro Arg Thr 
    1040                 1045                 1050             


Pro Arg  Thr Pro Arg Thr Pro  Arg Gly Gly Gly Thr  Ala Ser Gly 
    1055                 1060                 1065             


Gln Gly  Ser Val Lys Tyr Asp  Ser Thr Asp Gln Gly  Ser Pro Ala 
    1070                 1075                 1080             


Ser Thr  Pro Ser Thr Thr Arg  Pro Leu Asn Ser Val  Glu Pro Ala 
    1085                 1090                 1095             


Thr Met  Gln Pro Ile Pro Glu  Ala His Ser Leu Tyr  Val Thr Leu 
    1100                 1105                 1110             


Ile Leu  Ser Asp Ser Val Met  Asn Ile Phe Lys Asp  Arg Asn Phe 
    1115                 1120                 1125             


Asp Ser  Cys Cys Ile Cys Ala  Cys Asn Met Asn Ile  Lys Gly Ala 
    1130                 1135                 1140             


Asp Val  Gly Leu Tyr Ile Pro  Asp Ser Ser Asn Glu  Asp Gln Tyr 
    1145                 1150                 1155             


Arg Cys  Thr Cys Gly Phe Ser  Ala Ile Met Asn Arg  Lys Leu Gly 
    1160                 1165                 1170             


Tyr Asn  Ser Gly Leu Phe Leu  Glu Asp Glu Leu Asp  Ile Phe Gly 
    1175                 1180                 1185             


Lys Asn  Ser Asp Ile Gly Gln  Ala Ala Glu Arg Arg  Leu Met Met 
    1190                 1195                 1200             


Cys Gln  Ser Thr Phe Leu Pro  Gln Val Glu Gly Thr  Lys Lys Pro 
    1205                 1210                 1215             


Gln Glu  Pro Pro Ile Ser Leu  Leu Leu Leu Leu Gln  Asn Gln His 
    1220                 1225                 1230             


Thr Gln  Pro Phe Ala Ser Leu  Asn Phe Leu Asp Tyr  Ile Ser Ser 
    1235                 1240                 1245             


Asn Asn  Arg Gln Thr Leu Pro  Cys Val Ser Trp Ser  Tyr Asp Arg 
    1250                 1255                 1260             


Val Gln  Ala Asp Asn Asn Asp  Tyr Trp Thr Glu Cys  Phe Asn Ala 
    1265                 1270                 1275             


Leu Glu  Gln Gly Arg Gln Tyr  Val Asp Asn Pro Thr  Gly Gly Lys 
    1280                 1285                 1290             


Val Asp  Glu Ala Leu Val Arg  Ser Ala Thr Val His  Ser Trp Pro 
    1295                 1300                 1305             


His Ser  Asn Val Leu Asp Ile  Ser Met Leu Ser Ser  Gln Asp Val 
    1310                 1315                 1320             


Val Arg  Met Leu Leu Ser Leu  Gln Pro Phe Leu Gln  Asp Ala Ile 
    1325                 1330                 1335             


Gln Lys  Lys Arg Thr Gly Arg  Thr Trp Glu Asn Ile  Gln His Val 
    1340                 1345                 1350             


Gln Gly  Pro Leu Thr Trp Gln  Gln Phe His Lys Met  Ala Gly Arg 
    1355                 1360                 1365             


Gly Thr  Tyr Gly Ser Glu Glu  Ser Pro Glu Pro Leu  Pro Ile Pro 
    1370                 1375                 1380             


Thr Leu  Leu Val Gly Tyr Asp  Lys Asp Phe Leu Thr  Ile Ser Pro 
    1385                 1390                 1395             


Phe Ser  Leu Pro Phe Trp Glu  Arg Leu Leu Leu Asp  Pro Tyr Gly 
    1400                 1405                 1410             


Gly His  Arg Asp Val Ala Tyr  Ile Val Val Cys Pro  Glu Asn Glu 
    1415                 1420                 1425             


Ala Leu  Leu Glu Gly Ala Lys  Thr Phe Phe Arg Asp  Leu Ser Ala 
    1430                 1435                 1440             


Val Tyr  Glu Met Cys Arg Leu  Gly Gln His Lys Pro  Ile Cys Lys 
    1445                 1450                 1455             


Val Leu  Arg Asp Gly Ile Met  Arg Val Gly Lys Thr  Val Ala Gln 
    1460                 1465                 1470             


Lys Leu  Thr Asp Glu Leu Val  Ser Glu Trp Phe Asn  Gln Pro Trp 
    1475                 1480                 1485             


Ser Gly  Glu Glu Asn Asp Asn  His Ser Arg Leu Lys  Leu Tyr Ala 
    1490                 1495                 1500             


Gln Val  Cys Arg His His Leu  Ala Pro Tyr Leu Ala  Thr Leu Gln 
    1505                 1510                 1515             


Leu Asp  Ser Ser Leu Leu Ile  Pro Pro Lys Tyr Gln  Thr Pro Pro 
    1520                 1525                 1530             


Ala Ala  Ala Gln Gly Gln Ala  Thr Pro Gly Asn Ala  Gly Pro Leu 
    1535                 1540                 1545             


Ala Pro  Asn Gly Ser Ala Ala  Pro Pro Ala Gly Ser  Ala Phe Asn 
    1550                 1555                 1560             


Pro Thr  Ser Asn Ser Ser Ser  Thr Asn Pro Ala Ala  Ser Ser Ser 
    1565                 1570                 1575             


Ala Ser  Gly Ser Ser Val Pro  Pro Val Ser Ser Ser  Ala Ser Ala 
    1580                 1585                 1590             


Pro Gly  Ile Ser Gln Ile Ser  Thr Thr Ser Ser Ser  Gly Phe Ser 
    1595                 1600                 1605             


Gly Ser  Val Gly Gly Gln Asn  Pro Ser Thr Gly Gly  Ile Ser Ala 
    1610                 1615                 1620             


Asp Arg  Thr Gln Gly Asn Ile  Gly Cys Gly Gly Asp  Thr Asp Pro 
    1625                 1630                 1635             


Gly Gln  Ser Ser Ser Gln Pro  Ser Gln Asp Gly Gln  Glu Ser Val 
    1640                 1645                 1650             


Thr Glu  Arg Glu Arg Ile Gly  Ile Pro Thr Glu Pro  Asp Ser Ala 
    1655                 1660                 1665             


Asp Ser  His Ala His Pro Pro  Ala Val Val Ile Tyr  Met Val Asp 
    1670                 1675                 1680             


Pro Phe  Thr Tyr Ala Ala Glu  Glu Asp Ser Thr Ser  Gly Asn Phe 
    1685                 1690                 1695             


Trp Leu  Leu Ser Leu Met Arg  Cys Tyr Thr Glu Met  Leu Asp Asn 
    1700                 1705                 1710             


Leu Pro  Glu His Met Arg Asn  Ser Phe Ile Leu Gln  Ile Val Pro 
    1715                 1720                 1725             


Cys Gln  Tyr Met Leu Gln Thr  Met Lys Asp Glu Gln  Val Phe Tyr 
    1730                 1735                 1740             


Ile Gln  Tyr Leu Lys Ser Met  Ala Phe Ser Val Tyr  Cys Gln Cys 
    1745                 1750                 1755             


Arg Arg  Pro Leu Pro Thr Gln  Ile His Ile Lys Ser  Leu Thr Gly 
    1760                 1765                 1770             


Phe Gly  Pro Ala Ala Ser Ile  Glu Met Thr Leu Lys  Asn Pro Glu 
    1775                 1780                 1785             


Arg Pro  Ser Pro Ile Gln Leu  Tyr Ser Pro Pro Phe  Ile Leu Ala 
    1790                 1795                 1800             


Pro Ile  Lys Asp Lys Gln Thr  Glu Leu Gly Glu Thr  Phe Gly Glu 
    1805                 1810                 1815             


Ala Ser  Gln Lys Tyr Asn Val  Leu Phe Val Gly Tyr  Cys Leu Ser 
    1820                 1825                 1830             


His Asp  Gln Arg Trp Leu Leu  Ala Ser Cys Thr Asp  Leu His Gly 
    1835                 1840                 1845             


Glu Leu  Leu Glu Thr Cys Val  Val Asn Ile Ala Leu  Pro Asn Arg 
    1850                 1855                 1860             


Ser Arg  Arg Ser Lys Val Ser  Ala Arg Lys Ile Gly  Leu Gln Lys 
    1865                 1870                 1875             


Leu Trp  Glu Trp Cys Ile Gly  Ile Val Gln Met Thr  Ser Leu Pro 
    1880                 1885                 1890             


Trp Arg  Val Val Ile Gly Arg  Leu Gly Arg Leu Gly  His Gly Glu 
    1895                 1900                 1905             


Leu Lys  Asp Trp Ser Ile Leu  Leu Gly Glu Cys Ser  Leu Gln Thr 
    1910                 1915                 1920             


Ile Ser  Lys Lys Leu Lys Asp  Val Cys Arg Met Cys  Gly Ile Ser 
    1925                 1930                 1935             


Ala Ala  Asp Ser Pro Ser Ile  Leu Ser Ala Cys Leu  Val Ala Met 
    1940                 1945                 1950             


Glu Pro  Gln Gly Ser Phe Val  Val Met Pro Asp Ala  Val Thr Met 
    1955                 1960                 1965             


Gly Ser  Val Phe Gly Arg Ser  Thr Ala Leu Asn Met  Gln Ser Ser 
    1970                 1975                 1980             


Gln Leu  Asn Thr Pro Gln Asp  Ala Ser Cys Thr His  Ile Leu Val 
    1985                 1990                 1995             


Phe Pro  Thr Ser Ser Thr Ile  Gln Val Ala Pro Ala  Asn Tyr Pro 
    2000                 2005                 2010             


Asn Glu  Asp Gly Phe Ser Pro  Asn Asn Asp Asp Met  Phe Val Asp 
    2015                 2020                 2025             


Leu Pro  Phe Pro Asp Asp Met  Asp Asn Asp Ile Gly  Ile Leu Met 
    2030                 2035                 2040             


Thr Gly  Asn Leu His Ser Ser  Pro Asn Ser Ser Pro  Val Pro Ser 
    2045                 2050                 2055             


Pro Gly  Ser Pro Ser Gly Ile  Gly Val Gly Ser His  Phe Gln His 
    2060                 2065                 2070             


Ser Arg  Ser Gln Gly Glu Arg  Leu Leu Ser Arg Glu  Ala Pro Glu 
    2075                 2080                 2085             


Glu Leu  Lys Gln Gln Pro Leu  Ala Leu Gly Tyr Phe  Val Ser Thr 
    2090                 2095                 2100             


Ala Lys  Ala Glu Asn Leu Pro  Gln Trp Phe Trp Ser  Ser Cys Pro 
    2105                 2110                 2115             


Gln Ala  Gln Asn Gln Cys Pro  Leu Phe Leu Lys Ala  Ser Leu His 
    2120                 2125                 2130             


His His  Ile Ser Val Ala Gln  Thr Asp Glu Leu Leu  Pro Ala Arg 
    2135                 2140                 2145             


Asn Ser  Gln Arg Val Pro His  Pro Leu Asp Ser Lys  Thr Thr Ser 
    2150                 2155                 2160             


Asp Val  Leu Arg Phe Val Leu  Glu Gln Tyr Asn Ala  Leu Ser Trp 
    2165                 2170                 2175             


Leu Thr  Cys Asn Pro Ala Thr  Gln Asp Arg Thr Ser  Cys Leu Pro 
    2180                 2185                 2190             


Val His  Phe Val Val Leu Thr  Gln Leu Tyr Asn Ala  Ile Met Asn 
    2195                 2200                 2205             


Ile Leu  
    2210 


<210>  8
<211>  9393
<212>  DNA
<213>  Homo sapiens

<400>  8
ctcggacgcc tcgctccgac atgccccgct ctggcggccg ggctcgcgga ggatcatgac     60

tgcggcagcg aactgggtgg cgaacggggc gagcctggag gattgtcact ccaacctctt    120

ttcgctggct gaactcacgg gaatcaaatg gcgtaggtac aattttggag ggcatgggga    180

ctgtggaccc ataatttcag ccccagccca agatgatcca attctgttaa gtttcatccg    240

ctgtctgcaa gctaacctgc tttgtgtatg gcgtcgtgat gtcaaaccag attgcaaaga    300

gttatggata ttctggtggg gagatgaacc caacctagtg ggtgtaatac atcatgaact    360

gcaggttgtg gaagaaggac tctgggaaaa tggcctttcc tatgaatgta ggacgctgct    420

cttcaaagcg atccacaatc tgttagaaag gtgcctaatg gataagaact tcgttaggat    480

tgggaaatgg tttgtccgac cctacgaaaa ggatgaaaag ccagtcaaca aaagtgagca    540

tttgtcctgt gctttcacat tctttctgca tggagaaagt aatgtatgca caagtgtgga    600

gattgcccag caccagccaa tttatttgat caatgaggag catatacaca tggctcagtc    660

ttcacctgca ccatttcaag tactggtaag tccttatggc ttaaatggga cgctaacagg    720

ccaagcatac aagatgtcag acccagccac tcgtaagttg attgaggaat ggcagtattt    780

ctacccgatg gtgctaaaaa agaaagaaga atcgaaagag gaagacgagt tgggatatga    840

tgatgatttc cctgtggcag ttgaagtaat tgttggtggt gttcggatgg tttacccttc    900

agcatttgtt ttgatctctc agaatgacat cccggttcct cagagtgttg ccagtgctgg    960

aggccacatt gcagttgggc agcaagggct tggtagtgtg aaggacccaa gtaactgtgg   1020

gatgcctctg acccctccca cctctccaga acaggctatc ctaggtgaga gtggaggtat   1080

gcagagtgct gccagtcacc tggtttccca agatggaggg atgataacga tgcacagtcc   1140

aaagagatcg gggaagattc ctccaaaact ccacaatcat atggtccatc gagtctggaa   1200

ggaatgcatc ctcaacagaa cccagtccaa gaggagccaa atgtcaactc caactcttga   1260

agaagagcct gctagcaatc ctgctacttg ggattttgtg gatccaaccc aaagagtcag   1320

ctgttcttgt tccaggcata agcttttaaa acgttgtgca gtcgggccca atcgacctcc   1380

cacagtatct caaccagggt tcagtgcagg accatcatca tcttcatctt taccacctcc   1440

tgcttcttct aagcacaaaa cagcagaaag acaggaaaaa ggagacaagc tgcaaaagag   1500

acccttaata ccatttcacc ataggccctc tgtggccgaa gaattatgca tggagcaaga   1560

tacaccagga cagaaactag ggttggcagg gatagactcc tccttagagg tgtctagcag   1620

taggaaatat gataagcaaa tggccgtgcc ttccagaaat acaagcaagc aaatgaatct   1680

gaatcctatg gattcacctc attcccctat atcccctctg ccaccaacac tcagccctca   1740

gccacgaggt caggaaacag agagtttgga cccaccatcg gtccctgtga atccagccct   1800

ttatggaaat ggactagaac tccagcagtt gtctactctg gatgacagaa ctgtcctcgt   1860

aggccaaaga ctgcctctca tggcagaggt cagcgagaca gccttatatt gtgggattag   1920

gccctcgaac ccggagtcat cagaaaagtg gtggcatagt tatcgtctcc cacccagtga   1980

tgatgctgag ttcaggcctc cagagctcca gggtgagaga tgtgatgcca aaatggaggt   2040

aaactcagag agcactgcat tgcaaagact cttagcacaa cctaacaaac ggtttaaaat   2100

ctggcaagac aaacagcccc agttgcagcc actccacttc cttgacccat tgcctctatc   2160

acaacaacct ggagacagtt tgggagaagt gaatgaccca tatacctttg aagatggtga   2220

cataaaatac atctttacag ccaacaagaa atgcaaacaa gggacggaga aagattccct   2280

gaaaaagaat aagtcagagg atggatttgg taccaaggat gtcactacac caggtcattc   2340

cacgccggtg cctgatggga aaaatgccat gtctattttc agttctgcta ctaaaacaga   2400

tgtccggcag gataatgctg ctggcagagc tggctccagt agccttacac aggtaacaga   2460

tttggcacct tccctgcatg acttagacaa catctttgat aattctgatg acgacgaact   2520

tggggctgta tcacctgctc tgcgctcatc aaaaatgcct gcagttggga cagaagaccg   2580

acctcttggg aaggatggaa gagctgctgt tccttatcca ccaacagttg cagacttgca   2640

aaggatgttt cccactccac catctttgga acagcatcct gcattttctc ctgtgatgaa   2700

ttataaagat gggatcagct cagagacagt gacagcatta ggcatgatgg agagccctat   2760

ggtcagtatg gtttcaacac aactcacaga attcaaaatg gaagtggaag atggattagg   2820

aagtcccaag cccgaggaaa ttaaggactt ttcatatgtg cacaaagttc catcctttca   2880

accttttgtg ggatcctcca tgtttgctcc actgaagatg ttgccgagcc attgtttgct   2940

acctctgaag atacctgatg cctgtctgtt tcggccttca tgggcaattc ctcctaaaat   3000

tgaacaactg cccatgcccc ctgcagccac tttcattaga gatggctaca ataacgtgcc   3060

tagtgttggg agcctagcag atccagacta tctgaacaca ccacagatga acacacccgt   3120

gacgttgaac agcgctgccc cagccagcaa tagtggggca ggagtcctac catctccagc   3180

aacccctcgc ttctctgtcc ccacaccacg aacccccagg accccaagaa ctcccagagg   3240

tgggggcact gccagtggtc aagggtctgt taagtatgat agcaccgatc aaggatcacc   3300

agcctccacc ccctctacta cacggcccct caactctgtg gagcccgcca ccatgcagcc   3360

aattcccgaa gcccacagcc tctatgttac cctgattctc tccgattccg tgatgaatat   3420

ctttaaagac agaaactttg acagctgttg catctgtgcc tgcaacatga acatcaaagg   3480

ggcggatgtc gggctttaca tccccgattc ttccaatgag gaccagtacc gctgtacctg   3540

tgggtttagt gcgattatga accgcaaact tggctacaat tcaggactct tccttgaaga   3600

tgagttggat atttttggga agaattctga tattggtcag gctgcagaga ggcgcttaat   3660

gatgtgtcag tccaccttcc ttcctcaggt ggaaggaacc aaaaaacccc aggagccacc   3720

cataagcctt ctcctcctcc tccagaatca acacacacaa ccttttgctt cactgaattt   3780

cctggactac atttcctcta acaatcgcca aactcttccc tgtgtaagct ggagttatga   3840

ccgggtgcaa gcagataata atgattactg gacggaatgc tttaatgcgt tggagcaggg   3900

gcggcagtat gtggataacc ccactggtgg aaaagtggac gaagctctgg tgagaagtgc   3960

cactgtgcac tcttggcctc acagcaatgt gctggacatc agcatgctct cctcccagga   4020

tgtggttcgt atgctgttgt ccctgcagcc ctttctccaa gatgccatcc aaaagaagcg   4080

cacgggcagg acctgggaga acatccagca tgtgcaggga ccactcactt ggcagcagtt   4140

ccataaaatg gcaggacggg gaacctacgg ttcggaagaa tctcctgagc cgttgcccat   4200

ccccactctg ctggtaggct atgacaagga tttcctcacc atctcgccat tctccttgcc   4260

gttttgggag aggctcttgt tggacccata tgggggccac cgtgatgttg cctatattgt   4320

ggtgtgtcca gaaaatgagg ccttgctcga aggagccaaa actttcttca gggacttgag   4380

tgctgtatac gagatgtgta ggcttgggca gcacaagccc atctgcaaag tgctacgtga   4440

cgggatcatg cgcgtgggaa aaactgtggc acagaagctg acagatgagc ttgtgagtga   4500

gtggtttaac cagccttgga gcggcgagga gaatgacaat cattccagac tcaaacttta   4560

tgcgcaagtt tgccgccatc acctagcacc ttatttagcc actctgcagc ttgatagcag   4620

cctattgata ccacctaaat accagacccc accagcagca gcacagggac aagctacgcc   4680

agggaatgct gggcccttag ctccaaatgg atcagcagct cccccagctg gcagtgcatt   4740

taatcccacc tcgaatagta gttctacaaa tcctgcagca agtagttctg catctggttc   4800

ctctgtgcca ccggtctcat cgtctgcctc tgctcctggt attagccaga taagcactac   4860

ctcttcttca ggattcagtg gtagtgttgg agggcagaac cccagcactg ggggcatttc   4920

tgcggataga acgcaaggga acataggctg tggtggagac actgaccctg ggcagagctc   4980

ttctcagccc tcacaggatg gacaagagag tgttacagaa agggagagaa taggaattcc   5040

cacggagcct gactctgcag acagccatgc ccaccctcca gctgttgtca tttacatggt   5100

ggacccgttc acgtatgctg cagaggagga ctccacttct gggaactttt ggctgttgag   5160

cttgatgcgc tgctacacag aaatgctgga taatttacct gagcatatga gaaattcttt   5220

cattctccag attgtgcctt gccagtacat gctgcagaca atgaaggatg agcaagtttt   5280

ctacattcaa tacttgaagt ccatggcatt ttcagtgtac tgccagtgca ggcgaccact   5340

gcctacacag atccacatta aatccctcac gggatttggg cctgcagcca gcattgagat   5400

gaccctcaag aaccctgagc ggcccagccc aatccagctt tactcccctc cctttatatt   5460

ggccccaatc aaagacaagc agacagagct gggagagacg tttggtgagg cgagccagaa   5520

atacaatgtg ctcttcgtgg gctattgtct gtctcacgac cagcgctggc ttttggcttc   5580

ctgcactgac ctccatgggg aattattaga gacctgcgtt gtaaatattg ctttaccaaa   5640

caggtcacgg aggagtaaag tatctgcacg taaaattgga ctacagaagt tatgggagtg   5700

gtgcataggg attgtccaaa tgacatctct accctggaga gttgtaatcg ggcgacttgg   5760

gcgtcttggc catggggagc ttaaagattg gagtatcctc cttggagaat gttcactaca   5820

gacaatcagc aaaaagctca aggatgtgtg ccggatgtgt ggaatctctg ccgcagactc   5880

tccttctatc cttagtgcct gcctggttgc catggagccc caggggtcct ttgtagtgat   5940

gccagatgct gtcacaatgg gctctgtttt tggccgaagt actgcactga acatgcagtc   6000

atctcagctc aacacccctc aagatgcttc ttgtacacac atcttggtgt tcccaacatc   6060

atcaaccatc caggtggctc cagccaacta ccccaatgaa gatgggttta gccccaacaa   6120

tgatgatatg tttgttgacc ttccattccc agatgatatg gacaatgata ttggcatatt   6180

aatgactggg aacctccatt cctctcccaa ctcttcccca gtaccctccc caggctctcc   6240

ttctggaatt ggtgtgggct ctcacttcca gcatagtcgg agccagggtg agcgtcttct   6300

ttctagagaa gcaccagagg agctaaagca gcagcccctg gcccttgggt attttgtatc   6360

aactgccaaa gctgagaatc ttccccagtg gttttggtca tcgtgtcccc aggctcaaaa   6420

ccagtgccct ctcttcttaa aggcttcgct gcatcaccac atttcagtag cacagacaga   6480

cgaacttctg cctgccagga attctcagcg ggttccacac cctcttgact ccaaaaccac   6540

gtcggatgtt ttaaggtttg ttttggagca gtacaacgct ctgtcctggc tcacgtgcaa   6600

tccggccacc caggaccgta cttcctgcct tcccgtccac tttgtggtgc tcactcagtt   6660

gtacaatgcc atcatgaata tactttaatt ggaaaagcac ttgttctctc tggctcagtt   6720

ccttctccct gcaacctcag tccaaggaac ctgctacact ctgcaaataa cccacatcct   6780

tttcttcaga ccactctcca cagtcctgca ctgtgattcc ttctcagcag gcacatgtca   6840

attctgcagt gttcattacc agagtgactc cttgacactt ctctcatgga cctggaaact   6900

tccataagtg gtgactttca gccagtgcgg tggtgtgtgt agccccaacc actggtcccc   6960

aggaagtggt ggtggttgat ggcttttcag cgggaaacag aagagacagt gtccttttgc   7020

acaagagtct gtgttttcag cctctgtata caattgaggg cagtctagcc ctttggatga   7080

aatcctctta gttactggtg tatggcctgt gggttacctg aactccataa tctgggactt   7140

tttaaaaata agaaccagct caagtacatg gtttcatact ggggtttctg tctccctagt   7200

gttcccatcc agattagcat gagtgctttg gttgacttca aacctgtgtg tcaatgcaga   7260

aggtctggag acagcttcat tttgtttatt tattttaatt tgttttgtca tatggttttt   7320

gtgactttat ttttttaatt cacaaggacc aggtacagta gctgaaaccc aattcagatc   7380

caccatagga ttctttgact acatacctct gtcctagaag ccggaaaagg agtaaaaaca   7440

cattggggag atcatgccta aaagtaatat attcaaaacc acccagcagt aggttttgtt   7500

aacaacaaac tggattttaa aagttctgcc atgttaagtg gccagcattt catgaaggat   7560

aacattttta tacagaaggc agtcaagctc aactcagagc catggaggca agtaccttaa   7620

ttagttttat atagtcacaa cggaaatata ttttctagtg aattcttatt ggaagccagg   7680

tctctcctct cattagatca aaagggactt atgtacatac aacaattgaa agtgtttgct   7740

catgaaatca gttataaata tggtgaattt tttctggacc ataggaatat tatttcaaag   7800

aaatattaca acttaaccat taaattagta cttgaagttg agcctttgtg gtgggacttt   7860

ttaaaaaaat gcctttttaa agcattaatg gctaattgaa gtattttatg actcctcatt   7920

cctggcccag agggttgtct ttgaaaccct gtttctaacc cttgtgttgt gtgtttctgt   7980

ctgaggacag tgggtgtgta ctggcctccc gggagccact gtgaccaggc ctttgagctc   8040

ttgtcatctg tggagagaat catgcaaatt ttaaaagttc ttccaagaga cttccatgtc   8100

ctggttatta acaaaaaagg aaaaatgtaa taattgatat gattttgtaa aagtattttt   8160

cttgaaataa tctaaagttt aaaacattat attaaaaaaa aagttgtgtg gtgggaatgt   8220

gaaagcagag aaataacttg taaatggata attttgttct ctgtaccacc agttgaaggg   8280

ggggttgact ttcgcaatgt ataggataaa aaatctgata tatcaaacca tttgtatcta   8340

atgtgtacag tgtaaaattg actttaaaaa tattgcagtg ctattttttc ttaatcagaa   8400

aggaaaattc tcaaggcctt ttgaagagca taagaagatg aagattgtaa acttgtataa   8460

aattatcttg gtgagaagac aaattgtaaa gtagatattt gtaatctttt accactttgg   8520

ggttgctttt ttcccggaat tcatcagaac tttgaatttt ttttttaaat gggctgtttt   8580

taatgcaggg gcttttcttc cctagaaacc caattctaag cagaaaaaga aaaaaaacac   8640

aaaaaataaa aaacccctac aaaaaaactt taaaaaaaat ggcagcaaag ggtagttttc   8700

atctggtgtc ttttatttaa gttttttaag ttaagaaaag ctggtgacat atttatacgt   8760

ttttgtgcaa aaataaatga atggcaatag attttaaaaa atcttattat gtacttctgt   8820

gtgaaaaagt ctgtataata tttcccttaa atatgcatta ttttacttgt gagtttttta   8880

ctgaattaat ctgaaatgta caagccctgg atttgctaca gagtgagaag ttattttatt   8940

tttttttatt tttaattttg gaaattctgc agaaatcaga actcttacca tggtttgaac   9000

aaaaaaaggg gaaatgggga ggggaaaagg gtgggattgt ccagcatgct tgtatgtata   9060

tttcagaacc ttttttaaat gtaaaagctg tacatttctg ggaagttctg aatttctttt   9120

gtttcctttt ttccttcaag cattttgcag tgagcttctt ttatatatag caaacaattt   9180

gaaagaatac aaaaatatgt gaagttcatt taaaaaaata actacagtat agcgctggta   9240

cagtacacta aaagactttg ataaaaagaa acaataataa aaggcctcca ttttaaatgt   9300

cattcatata taccttgtgg atgagagcta tatactttta cacacttttt tagaggaata   9360

aattattgaa ttactgaaaa aaaaaaaaaa aaa                                9393


<210>  9
<211>  889
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Gly Gly Leu Ala Asp Gly Glu Pro Asp Arg Thr Ser Leu Leu 
1               5                   10                  15      


Gly Asp Ser Lys Asp Val Leu Gly Pro Ser Thr Val Val Ala Asn Ser 
            20                  25                  30          


Asp Glu Ser Gln Leu Leu Thr Pro Gly Lys Met Ser Gln Arg Gln Gly 
        35                  40                  45              


Lys Glu Ala Tyr Pro Thr Pro Thr Lys Asp Leu His Gln Pro Ser Leu 
    50                  55                  60                  


Ser Pro Ala Ser Pro His Ser Gln Gly Phe Glu Arg Gly Lys Glu Asp 
65                  70                  75                  80  


Ile Ser Gln Asn Lys Asp Glu Ser Ser Leu Ser Met Ser Lys Ser Lys 
                85                  90                  95      


Ser Glu Ser Lys Leu Tyr Asn Gly Ser Glu Lys Asp Ser Ser Thr Ser 
            100                 105                 110         


Ser Lys Leu Thr Lys Lys Glu Ser Leu Lys Val Gln Lys Lys Asn Tyr 
        115                 120                 125             


Arg Glu Glu Lys Lys Arg Ala Thr Lys Glu Leu Leu Ser Thr Ile Thr 
    130                 135                 140                 


Asp Pro Ser Val Ile Val Met Ala Asp Trp Leu Lys Ile Arg Gly Thr 
145                 150                 155                 160 


Leu Lys Ser Trp Thr Lys Leu Trp Cys Val Leu Lys Pro Gly Val Leu 
                165                 170                 175     


Leu Ile Tyr Lys Thr Gln Lys Asn Gly Gln Trp Val Gly Thr Val Leu 
            180                 185                 190         


Leu Asn Ala Cys Glu Ile Ile Glu Arg Pro Ser Lys Lys Asp Gly Phe 
        195                 200                 205             


Cys Phe Lys Leu Phe His Pro Leu Glu Gln Ser Ile Trp Ala Val Lys 
    210                 215                 220                 


Gly Pro Lys Gly Glu Ala Val Gly Ser Ile Thr Gln Pro Leu Pro Ser 
225                 230                 235                 240 


Ser Tyr Leu Ile Ile Arg Ala Thr Ser Glu Ser Asp Gly Arg Cys Trp 
                245                 250                 255     


Met Asp Ala Leu Glu Leu Ala Leu Lys Cys Ser Ser Leu Leu Lys Arg 
            260                 265                 270         


Thr Met Ile Arg Glu Gly Lys Glu His Asp Leu Ser Val Ser Ser Asp 
        275                 280                 285             


Ser Thr His Val Thr Phe Tyr Gly Leu Leu Arg Ala Asn Asn Leu His 
    290                 295                 300                 


Ser Gly Asp Asn Phe Gln Leu Asn Asp Ser Glu Ile Glu Arg Gln His 
305                 310                 315                 320 


Phe Lys Asp Gln Asp Met Tyr Ser Asp Lys Ser Asp Lys Glu Asn Asp 
                325                 330                 335     


Gln Glu His Asp Glu Ser Asp Asn Glu Val Met Gly Lys Ser Glu Glu 
            340                 345                 350         


Ser Asp Thr Asp Thr Ser Glu Arg Gln Asp Asp Ser Tyr Ile Glu Pro 
        355                 360                 365             


Glu Pro Val Glu Pro Leu Lys Glu Thr Thr Tyr Thr Glu Gln Ser His 
    370                 375                 380                 


Glu Glu Leu Gly Glu Ala Gly Glu Ala Ser Gln Thr Glu Thr Val Ser 
385                 390                 395                 400 


Glu Glu Asn Lys Ser Leu Ile Trp Thr Leu Leu Lys Gln Val Arg Pro 
                405                 410                 415     


Gly Met Asp Leu Ser Lys Val Val Leu Pro Thr Phe Ile Leu Glu Pro 
            420                 425                 430         


Arg Ser Phe Leu Asp Lys Leu Ser Asp Tyr Tyr Tyr His Ala Asp Phe 
        435                 440                 445             


Leu Ser Glu Ala Ala Leu Glu Glu Asn Pro Tyr Phe Arg Leu Lys Lys 
    450                 455                 460                 


Val Val Lys Trp Tyr Leu Ser Gly Phe Tyr Lys Lys Pro Lys Gly Leu 
465                 470                 475                 480 


Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Thr Phe Arg Cys Leu Trp 
                485                 490                 495     


Ile His Pro Arg Thr Asn Ser Lys Thr Phe Tyr Ile Ala Glu Gln Val 
            500                 505                 510         


Ser His His Pro Pro Ile Ser Ala Phe Tyr Val Ser Asn Arg Lys Asp 
        515                 520                 525             


Gly Phe Cys Leu Ser Gly Ser Ile Leu Ala Lys Ser Lys Phe Tyr Gly 
    530                 535                 540                 


Asn Ser Leu Ser Ala Ile Leu Glu Gly Glu Ala Arg Leu Thr Phe Leu 
545                 550                 555                 560 


Asn Arg Gly Glu Asp Tyr Val Met Thr Met Pro Tyr Ala His Cys Lys 
                565                 570                 575     


Gly Ile Leu Tyr Gly Thr Met Thr Leu Glu Leu Gly Gly Thr Val Asn 
            580                 585                 590         


Ile Thr Cys Gln Lys Thr Gly Tyr Ser Ala Ile Leu Glu Phe Lys Leu 
        595                 600                 605             


Lys Pro Phe Leu Gly Ser Ser Asp Cys Val Asn Gln Ile Ser Gly Lys 
    610                 615                 620                 


Leu Lys Leu Gly Lys Glu Val Leu Ala Thr Leu Glu Gly His Trp Asp 
625                 630                 635                 640 


Ser Glu Val Phe Ile Thr Asp Lys Lys Thr Asp Asn Ser Glu Val Phe 
                645                 650                 655     


Trp Asn Pro Thr Pro Asp Ile Lys Gln Trp Arg Leu Ile Arg His Thr 
            660                 665                 670         


Val Lys Phe Glu Glu Gln Gly Asp Phe Glu Ser Glu Lys Leu Trp Gln 
        675                 680                 685             


Arg Val Thr Arg Ala Ile Asn Ala Lys Asp Gln Thr Glu Ala Thr Gln 
    690                 695                 700                 


Glu Lys Tyr Val Leu Glu Glu Ala Gln Arg Gln Ala Ala Arg Asp Arg 
705                 710                 715                 720 


Lys Thr Lys Asn Glu Glu Trp Ser Cys Lys Leu Phe Glu Leu Asp Pro 
                725                 730                 735     


Leu Thr Gly Glu Trp His Tyr Lys Phe Ala Asp Thr Arg Pro Trp Asp 
            740                 745                 750         


Pro Leu Asn Asp Met Ile Gln Phe Glu Lys Asp Gly Val Ile Gln Thr 
        755                 760                 765             


Lys Val Lys His Arg Thr Pro Met Val Ser Val Pro Lys Met Lys His 
    770                 775                 780                 


Lys Pro Thr Arg Gln Gln Lys Lys Val Ala Lys Gly Tyr Ser Ser Pro 
785                 790                 795                 800 


Glu Pro Asp Ile Gln Asp Ser Ser Gly Ser Glu Ala Gln Ser Val Lys 
                805                 810                 815     


Pro Ser Thr Arg Arg Lys Lys Gly Ile Glu Leu Gly Asp Ile Gln Ser 
            820                 825                 830         


Ser Ile Glu Ser Ile Lys Gln Thr Gln Glu Glu Ile Lys Arg Asn Ile 
        835                 840                 845             


Met Ala Leu Arg Asn His Leu Val Ser Ser Thr Pro Ala Thr Asp Tyr 
    850                 855                 860                 


Phe Leu Gln Gln Lys Asp Tyr Phe Ile Ile Phe Leu Leu Ile Leu Leu 
865                 870                 875                 880 


Gln Val Ile Ile Asn Phe Met Phe Lys 
                885                 


<210>  10
<211>  7259
<212>  DNA
<213>  Homo sapiens

<400>  10
cactagaatg tgaaggatct tcgcggttct gggtgcccag aaaggcggcg acgcggcgga     60

tgacaacatt aggccgcgac gcgctcctgg ccaggcggcg gctgtagtgt tagctttgga    120

cgccgcagta gccgctgccg gtagcaagcc gactgaggga aggtgggggt ccgcccgggc    180

tggtggacct cggggccgaa agttcccgcc ccgctcgggg gctgagccgg cagtgcctcc    240

gcggccgctg ggcagcgccc ttcgtccagg ctcgcgcccc agctgccgcc gacgacagcg    300

gccgagagaa gttggggtct gactagacgc ttacggggcc tcggaccccg gcgccgcggc    360

gacctcggag gaaccggctc cttgcgtccc gcctccctgg gagctccgca cgggatttgc    420

agatttacag aatggctgca cattaatgga aagagaagca taaacctatc ttctttcatt    480

atggagggag gtttggcaga tggagaacct gatcgaactt cgcttcttgg tgatagcaaa    540

gatgtccttg ggccatcaac tgttgtagca aacagtgacg aatctcagct tctgacacca    600

ggaaagatga gtcagcgcca aggaaaagaa gcttatccaa cgccaaccaa agatttgcat    660

cagccatctc ttagtccagc aagtcctcat agccagggtt ttgaaagagg gaaggaagat    720

atttctcaaa ataaagatga atcttcactt tctatgtcaa agagcaagtc tgaatctaaa    780

ctttataatg gctcagagaa ggacagttca acttcaagca aactcacaaa aaaagaatct    840

cttaaggtac aaaagaaaaa ttaccgagaa gaaaagaaaa gagccacaaa ggagctgctc    900

agtacaatca cagatccttc tgttattgtt atggctgatt ggttaaagat tcgtggtact    960

ctaaagagct ggaccaagtt atggtgtgtg ttgaaacctg gggtgctact gatctataaa   1020

acccaaaaaa atggtcagtg ggtaggaaca gttcttctga atgcctgtga aatcattgaa   1080

cgtccatcaa aaaaggatgg cttttgtttc aaacttttcc atcctttgga gcaatctatt   1140

tgggcagtga agggtccaaa aggtgaagcg gttggatcca ttactcaacc cttacctagc   1200

agttatttga tcatccgagc tacttcagag tcagatggaa ggtgctggat ggatgctttg   1260

gagttggctt tgaaatgttc tagtcttctt aaacgtacaa tgatcagaga aggaaaggaa   1320

catgacctga gcgtttcatc agatagcaca catgtgactt tctatggctt actacgtgct   1380

aacaatctcc acagtggtga taacttccag ttaaatgata gtgaaattga acgacaacat   1440

tttaaggacc aagatatgta ttctgataaa tctgataaag aaaatgatca agaacatgat   1500

gagtctgata atgaggtgat ggggaaaagt gaagaaagtg acacagatac atcagaaaga   1560

caagatgact catatatcga acctgagcct gttgagcctt taaaggagac tacctacact   1620

gaacagagcc atgaagaact tggagaggca ggtgaggctt ctcaaacaga aactgtatct   1680

gaagaaaaca aaagccttat ctggacacta ttgaaacaag tccgtcctgg catggaccta   1740

tccaaggtgg ttctgcctac atttattttg gaaccccgtt ctttcctgga taaactttca   1800

gattactact atcatgcaga tttcctatct gaggcagctc ttgaagaaaa tccttatttc   1860

cgtttgaaga aagtagtgaa atggtatttg tcaggattct ataaaaagcc aaagggactg   1920

aagaaacctt ataatcctat acttggcgag actttccgtt gtttatggat tcatcccaga   1980

acaaacagca aaacttttta tattgctgaa caggtgtccc atcatccacc aatatctgcc   2040

ttttatgtta gtaatcgaaa agatggattt tgccttagcg gtagtatcct ggctaagtct   2100

aagttttatg gaaactcatt atctgcaata ttagagggag aagcacggtt aactttcttg   2160

aatagaggtg aagattatgt aatgacaatg ccatacgctc attgtaaagg aattctttat   2220

ggtacaatga cactggagct tggtggaaca gtcaatatta catgtcaaaa aactggatac   2280

agtgcaatac ttgaatttaa actaaagcca ttcctaggga gtagtgactg tgttaatcaa   2340

atatcaggga aacttaaact gggaaaagaa gtcctagcta ctttggaagg tcattgggat   2400

agtgaagttt ttattactga taaaaagact gataattcag aggttttctg gaatccaaca   2460

cctgacatta agcaatggag attaataagg cacactgtaa aatttgaaga acagggagat   2520

tttgaatcag agaaactctg gcaacgggta actcgagcca taaatgccaa agaccaaact   2580

gaagctaccc aagagaagta tgttttggaa gaagctcaaa gacaagctgc cagggatcgg   2640

aaaacaaaaa atgaagagtg gtcttgcaaa ttatttgaac ttgatccact cacaggagaa   2700

tggcattaca agtttgcaga tacccgacca tgggacccac ttaatgatat gatacagttt   2760

gaaaaagatg gtgttattca gaccaaagtg aaacatcgta ctccaatggt tagcgtcccc   2820

aaaatgaaac ataagccaac caggcaacag aagaaagtag caaaaggcta ttcctcccca   2880

gaacctgaca ttcaagactc ctctggaagt gaagctcaat cagtaaaacc aagtacaaga   2940

agaaagaaag gaatagaact gggagacatt cagagttcca tcgaatctat aaaacaaaca   3000

caggaagaaa ttaaaagaaa tattatggct cttcgaaatc atttagtttc aagcacaccg   3060

gccacggatt attttctgca acaaaaagac tacttcatca ttttcctcct gattttgctt   3120

caagtcataa taaacttcat gttcaagtag aagttctcta ccattgaatc agtgaactag   3180

aaagatctga tttggcctgg gaccagtgtt caagttggtt tggtctttat taaaaatcac   3240

aatattccga aaacaaaaaa acctaggaga taaatgtaga ggtattgact tttcgtatct   3300

tttatcttca cactgaaaca agagctatcc tatttgatta ttaaagtgag ctatgtgtta   3360

agtgccagga catttctagc ttttgtgaga atgtgtctac atatgagtat aataaaccca   3420

catgtataca caattgtctc ttatgtactc ctacctgaca gtagtctttg tattctatag   3480

tatgttctga gatataatgt taacattgtt cataacaaaa aatgctatca atcttataaa   3540

tatatgtaat ctattttctt cataaaacag gcacaaaagt tttatcagta aggaattaca   3600

gattgagaaa tgatggaata atagacataa ttaattcaat acactactgt taaaatcatt   3660

tgcaaagcac tcagctcaat tatcttctta gaaagaaaga aaaagtatga atggtcaaaa   3720

tgaatacatc gagagagata aatggcaaat tgctttttta aaagtttaca taagtttttt   3780

ttaaccccta gaatttaata tttgtagatg caggtaaata tatatactta cgtgtatatc   3840

agtataaaaa cactggtgtg caattaattg gattgattat aataccacct taagcacttg   3900

ctgaaaaaag tgtggtcaaa attgattgct gtccttttgt cttatttttg tttttcttaa   3960

gtcagctggt tcataacata ggccaaattc tagagatgtt tatagagcat ttgaagtgct   4020

gataatttat gttttttcat tatgaaaact tattttagct ttagactcca gtgtgttcag   4080

tgaataagta gaatataaaa aaatataacc agtattttac ttcaaaagcc aaaaagaggc   4140

aataagaaaa gacactttgt ggtggccttt atgtgtgcat taaaattggt ttctgtaaaa   4200

cgtgtaataa gttgagtatc tacgaagagt atcaagttct gaagtttaat ttttttatta   4260

tcctcctctc ttcttagtaa cttctttctg tggcaaaacc acaattcttt aagattccta   4320

ttgttcaggc taaggcaaat ttttttgttt gtttcttcag tttaatattt tgattttgtg   4380

tttttacgta aatatttata ttccttgaaa gcaatttttg ccaaggtagt tcagtttagg   4440

aatatgttgt tctaaaatat gtcttagaat cctgaaagca tagattttga aatgtttttt   4500

taatgaaaat gaaggtcaga gagaataatt gccctgacca catttgcctt tcagtaggag   4560

gaggctgtga aatagtaaaa ttataatcgt ttatgccatg ataaatacaa gattggtaaa   4620

taaatacatt gattggtaaa ttatgagaat caaaatgata aaaagagcct gcttttttcc   4680

ctaaccaata tagctatctt aagtatcctt aggtttctgt gaagaaccat ttcccatgtt   4740

ttcttggcaa aataatgctg tattccatat gtacatgtga aatgatgttt taaattgata   4800

aaagcttaaa taagatctac ctatacccag tattttcatg atattagaac aaatgggttt   4860

ttggttatat tttatatttg tcaatataat ttttgtattc acattctgtt acactctgcc   4920

tattcattga tatatgatat tctgtaaata ttgtacaatt tgatcttttt tatggtttaa   4980

attagttaat tacatacaaa ttgattggct tatcacaaaa atcatttcat cagtaaacct   5040

tgttaacatt ttgtactggt gacccacctc ttaggacttt ggtcttatcc acgtgtatgt   5100

tgttttcatt tggtccaaat aatattttat ttgtatgggt atcttctaag actaaatagg   5160

tagttgtgtt ctttattttt aaaatttctt tttagagcaa atgttatggg ttcttaccca   5220

aagagtcaaa aactatttct taagaaagag cagagttatt catgactgtt ctttatacac   5280

taaaagcatg catctaatct aatagtcctc ttattatgct tttagttgta tgagtctctt   5340

tctatgaact gaacacaaaa ctcaggaatt ggtggcttaa ttttagatca gtgcttgtac   5400

taggcttagt tatatgaatc tttataacac ataattacta actttgtagc catatatgta   5460

attgactttg aatgttattt acctgaaatt aatcttcctt cacacatgga ccgtaaacgg   5520

ttcccagttg tctgagagcc tcatgagggt ttctaggatt tatgacctta tgaccagttt   5580

ttttcattta ccaagatttt attttcctac atgaaaattt aattgagtaa taattattca   5640

catgtgcatt ttctttttag ctgttaaatg tactatgcca tcatccacca tttagtaaaa   5700

tgtagctggc ccaggacatg taaaaaaaaa aaaaaaacaa caacaataaa tagggcatgt   5760

gaaatgttaa gttacagcaa tagatatttt atttgtattt catgttagta cttttttgtt   5820

ttatatcact tataaaggta cagtgtactc tttgtcacag ctcagttggt aaccgcattc   5880

cattgaaaag ttggccttgt aaaatacaac tctcatttaa tattcatgct tttgtgcctt   5940

taagaaaata ttttttgtca ttttttgtgt tacagaacta taatgtgatt caaggtgttt   6000

ataggcttgt cataaaaggg tcatttctgt gtgttacttt ctttttatat agctatagta   6060

tatttaaaca ataatactat cttttatagg ggtttgtcta tttacctatt ctttactcag   6120

acattgatgt agacttgtca gattattctg agtattgtta acagtgcctt ttcgatggaa   6180

tcacactttt tggctgtcac cttgtgccat atacacacaa aattttgtgg aaggcagttt   6240

taactttctg aagaatatct gtcaaaattt aagaaaacaa atgtataaaa ttccattttt   6300

tccagtgttt agcatttcta gtaagcagtg aggttgtttg acatacagtg atgatggcat   6360

tattgataag ccatacatga gactgcagat tatattgaat catattaaat gtacagaaat   6420

aaaatattag atttatatca aattttccaa tttgaaccag tggggaaaat cccacagaaa   6480

tcagtaagtt tacatttcaa tttctatctt atttgactaa gtggaaagag attctttaaa   6540

atgtataacc tgccattatg taatttggtt tcattttatt ctacctgttg tgtgagttta   6600

gtatatttaa tttacttttt gttactcttt acatactgtt tatttttgtt agtttttaat   6660

tgaagatgga ctgttgaaat tgtataggac cagtgtctta ttaatatgat taatatattt   6720

agaagagcca cgtgaaaccc atgacaaaat gaatgtgaat attctttcta aaaatttaga   6780

aaatgttatc tttttgcatt tattatgtaa aactgtttta cagtatcaaa atttttcact   6840

taaagaaaaa aaatgccatg aaacatttga actgatgagc cacagaactt cagttgaaat   6900

ttttttcact ttttagcatg ctaaatatac atctgagttt aaatgttctg tttaatggcc   6960

attcataaat tcaagcacta ccactggtca gttttgtgtg atagaataaa aatatgttac   7020

ctgcagtgta agtacagcac actgtcaaat tcttttcctt aaggtgcaca gtaaatgtac   7080

agatagttat aggccactgt tttgtaatgt agtacatttc taatctatta ttcctaacct   7140

attataactg tttgcagaaa gaaaagaatt tttctaataa tctgtaaaat tatgctaact   7200

tctacaagta ggcttctaaa taaaattttt aaaaagagca aaaaaaaaaa aaaaaaaaa    7259


<210>  11
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Glu Arg Glu Val Ser Thr Ala Pro Ala Gly Thr Asp Met Pro 
1               5                   10                  15      


Ala Ala Lys Lys Gln Lys Leu Ser Ser Asp Glu Asn Ser Asn Pro Asp 
            20                  25                  30          


Leu Ser Gly Asp Glu Asn Asp Asp Ala Val Ser Ile Glu Ser Gly Thr 
        35                  40                  45              


Asn Thr Glu Arg Pro Asp Thr Pro Thr Asn Thr Pro Asn Ala Pro Gly 
    50                  55                  60                  


Arg Lys Ser Trp Gly Lys Gly Lys Trp Lys Ser Lys Lys Cys Lys Tyr 
65                  70                  75                  80  


Ser Phe Lys Cys Val Asn Ser Leu Lys Glu Asp His Asn Gln Pro Leu 
                85                  90                  95      


Phe Gly Val Gln Phe Asn Trp His Ser Lys Glu Gly Asp Pro Leu Val 
            100                 105                 110         


Phe Ala Thr Val Gly Ser Asn Arg Val Thr Leu Tyr Glu Cys His Ser 
        115                 120                 125             


Gln Gly Glu Ile Arg Leu Leu Gln Ser Tyr Val Asp Ala Asp Ala Asp 
    130                 135                 140                 


Glu Asn Phe Tyr Thr Cys Ala Trp Thr Tyr Asp Ser Asn Thr Ser His 
145                 150                 155                 160 


Pro Leu Leu Ala Val Ala Gly Ser Arg Gly Ile Ile Arg Ile Ile Asn 
                165                 170                 175     


Pro Ile Thr Met Gln Cys Ile Lys His Tyr Val Gly His Gly Asn Ala 
            180                 185                 190         


Ile Asn Glu Leu Lys Phe His Pro Arg Asp Pro Asn Leu Leu Leu Ser 
        195                 200                 205             


Val Ser Lys Asp His Ala Leu Arg Leu Trp Asn Ile Gln Thr Asp Thr 
    210                 215                 220                 


Leu Val Ala Ile Phe Gly Gly Val Glu Gly His Arg Asp Glu Val Leu 
225                 230                 235                 240 


Ser Ala Asp Tyr Asp Leu Leu Gly Glu Lys Ile Met Ser Cys Gly Met 
                245                 250                 255     


Asp His Ser Leu Lys Leu Trp Arg Ile Asn Ser Lys Arg Met Met Asn 
            260                 265                 270         


Ala Ile Lys Glu Ser Tyr Asp Tyr Asn Pro Asn Lys Thr Asn Arg Pro 
        275                 280                 285             


Phe Ile Ser Gln Lys Ile His Phe Pro Asp Phe Ser Thr Arg Asp Ile 
    290                 295                 300                 


His Arg Asn Tyr Val Asp Cys Val Arg Trp Leu Gly Asp Leu Ile Leu 
305                 310                 315                 320 


Ser Lys Ser Cys Glu Asn Ala Ile Val Cys Trp Lys Pro Gly Lys Met 
                325                 330                 335     


Glu Asp Asp Ile Asp Lys Ile Lys Pro Ser Glu Ser Asn Val Thr Ile 
            340                 345                 350         


Leu Gly Arg Phe Asp Tyr Ser Gln Cys Asp Ile Trp Tyr Met Arg Phe 
        355                 360                 365             


Ser Met Asp Phe Trp Gln Lys Met Leu Ala Leu Gly Asn Gln Val Gly 
    370                 375                 380                 


Lys Leu Tyr Val Trp Asp Leu Glu Val Glu Asp Pro His Lys Ala Lys 
385                 390                 395                 400 


Cys Thr Thr Leu Thr His His Lys Cys Gly Ala Ala Ile Arg Gln Thr 
                405                 410                 415     


Ser Phe Ser Arg Asp Ser Ser Ile Leu Ile Ala Val Cys Asp Asp Ala 
            420                 425                 430         


Ser Ile Trp Arg Trp Asp Arg Leu Arg 
        435                 440     


<210>  12
<211>  2006
<212>  DNA
<213>  Homo sapiens

<400>  12
ctagcagcgg gtcggagatc gaaggaacgg gccaattgcg gctgaaacgt ctttggaagg     60

aggaaggggg tgagggagca tccctttgag tttcgcctct tctcgaggcg gtggtgggaa    120

gggagacata cttaatactg ccctcttaat ccaacggacc ttacatcgtg tagactgccg    180

ggagggcggc gggaaaaggg caagacggga gttggggaag ggaaggagcc aggaagccgc    240

gcgggagggc gcgcgcgcgc gccccttttt cagcagtgtg gcggggtcgc acgcacgccc    300

gcctcggcgg ctgggcgcga tttgcgacag tggggggggc ggtggaggtg gcggcggcag    360

cggcaacttt gcggcaagct cgggccgggc ttgcttgacg gcggtgtggc ggaggccccg    420

ccccaggcgg caggaacctg gagggaggcg gaggaatatg tccgagaggg aagtgtcgac    480

tgcgccggcg ggaacagaca tgcctgcggc caagaagcag aagctgagca gtgacgagaa    540

cagcaatcca gacctctctg gagacgagaa tgatgacgct gtcagtatag aaagtggtac    600

aaacactgaa cgccctgata cacctacaaa cacgccaaat gcacctggaa ggaaaagttg    660

gggaaaggga aaatggaagt caaagaaatg caaatattct ttcaaatgtg taaatagtct    720

caaggaagat cataaccaac cattgtttgg agttcagttt aactggcaca gtaaagaagg    780

agatccatta gtgtttgcaa ctgtaggaag caacagagtt accttgtatg aatgtcattc    840

acaaggagaa atccggttgt tgcaatctta cgtggatgct gatgctgatg aaaactttta    900

cacttgtgca tggacctatg atagcaatac gagccatcct ctgctggctg tagctggatc    960

tagaggcata attaggataa taaatcctat aacaatgcag tgtataaagc actatgttgg   1020

ccatggaaat gctatcaatg agctgaaatt ccatccaaga gatccaaatc ttctcctgtc   1080

agtaagtaaa gatcatgctt tacgattatg gaatatccag acggacactc tggtggcaat   1140

atttggaggc gtagaagggc acagagatga agttctaagt gctgattatg atcttttggg   1200

tgaaaaaata atgtcctgtg gtatggatca ttctcttaaa ctttggagga tcaattcaaa   1260

gagaatgatg aatgcaatta aggaatctta tgattataat ccaaataaaa ctaacaggcc   1320

atttatttct cagaaaatcc attttcctga tttttctacc agagacatac ataggaatta   1380

tgttgattgt gtgcgatggt taggcgattt gatactttct aagtcttgtg aaaatgccat   1440

tgtgtgctgg aaacctggca agatggaaga tgatatagat aaaattaaac ccagtgaatc   1500

taatgtgact attcttgggc gatttgatta cagccagtgt gacatttggt acatgaggtt   1560

ttctatggat ttctggcaaa agatgcttgc attgggcaat caagttggca aactttatgt   1620

ttgggattta gaagtagaag atcctcataa agccaaatgt acaacactga ctcatcataa   1680

atgtggtgct gctattcgac aaaccagttt tagcagggat agcagcattc ttatagctgt   1740

ttgtgatgat gccagtattt ggcgctggga tcgacttcga taaaatactt ttgcctaatc   1800

aaaattagag tgtgtttgtt gtctgtgtaa aatagaatta atgtatcttg ctagtaaggg   1860

cacgtagagc atttagagtt gtctttcagc attcaatcag gctgagctga atgtagtgat   1920

gtttacattg tttacattct ttgtactgtc ttcctgctca gactctactg cttttaataa   1980

aaatttattt ttgtaaaaaa aaaaaa                                        2006


<210>  13
<211>  1192
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Pro Ala Pro Glu Gln Ala Ser Leu Val Glu Glu Gly Gln Pro Gln 
1               5                   10                  15      


Thr Arg Gln Glu Ala Ala Ser Thr Gly Pro Gly Met Glu Pro Glu Thr 
            20                  25                  30          


Thr Ala Thr Thr Ile Leu Ala Ser Val Lys Glu Gln Glu Leu Gln Phe 
        35                  40                  45              


Gln Arg Leu Thr Arg Glu Leu Glu Val Glu Arg Gln Ile Val Ala Ser 
    50                  55                  60                  


Gln Leu Glu Arg Cys Arg Leu Gly Ala Glu Ser Pro Ser Ile Ala Ser 
65                  70                  75                  80  


Thr Ser Ser Thr Glu Lys Ser Phe Pro Trp Arg Ser Thr Asp Val Pro 
                85                  90                  95      


Asn Thr Gly Val Ser Lys Pro Arg Val Ser Asp Ala Val Gln Pro Asn 
            100                 105                 110         


Asn Tyr Leu Ile Arg Thr Glu Pro Glu Gln Gly Thr Leu Tyr Ser Pro 
        115                 120                 125             


Glu Gln Thr Ser Leu His Glu Ser Glu Gly Ser Leu Gly Asn Ser Arg 
    130                 135                 140                 


Ser Ser Thr Gln Met Asn Ser Tyr Ser Asp Ser Gly Tyr Gln Glu Ala 
145                 150                 155                 160 


Gly Ser Phe His Asn Ser Gln Asn Val Ser Lys Ala Asp Asn Arg Gln 
                165                 170                 175     


Gln His Ser Phe Ile Gly Ser Thr Asn Asn His Val Val Arg Asn Ser 
            180                 185                 190         


Arg Ala Glu Gly Gln Thr Leu Val Gln Pro Ser Val Ala Asn Arg Ala 
        195                 200                 205             


Met Arg Arg Val Ser Ser Val Pro Ser Arg Ala Gln Ser Pro Ser Tyr 
    210                 215                 220                 


Val Ile Ser Thr Gly Val Ser Pro Ser Arg Gly Ser Leu Arg Thr Ser 
225                 230                 235                 240 


Leu Gly Ser Gly Phe Gly Ser Pro Ser Val Thr Asp Pro Arg Pro Leu 
                245                 250                 255     


Asn Pro Ser Ala Tyr Ser Ser Thr Thr Leu Pro Ala Ala Arg Ala Ala 
            260                 265                 270         


Ser Pro Tyr Ser Gln Arg Pro Ala Ser Pro Thr Ala Ile Arg Arg Ile 
        275                 280                 285             


Gly Ser Val Thr Ser Arg Gln Thr Ser Asn Pro Asn Gly Pro Thr Pro 
    290                 295                 300                 


Gln Tyr Gln Thr Thr Ala Arg Val Gly Ser Pro Leu Thr Leu Thr Asp 
305                 310                 315                 320 


Ala Gln Thr Arg Val Ala Ser Pro Ser Gln Gly Gln Val Gly Ser Ser 
                325                 330                 335     


Ser Pro Lys Arg Ser Gly Met Thr Ala Val Pro Gln His Leu Gly Pro 
            340                 345                 350         


Ser Leu Gln Arg Thr Val His Asp Met Glu Gln Phe Gly Gln Gln Gln 
        355                 360                 365             


Tyr Asp Ile Tyr Glu Arg Met Val Pro Pro Arg Pro Asp Ser Leu Thr 
    370                 375                 380                 


Gly Leu Arg Ser Ser Tyr Ala Ser Gln His Ser Gln Leu Gly Gln Asp 
385                 390                 395                 400 


Leu Arg Ser Ala Val Ser Pro Asp Leu His Ile Thr Pro Ile Tyr Glu 
                405                 410                 415     


Gly Arg Thr Tyr Tyr Ser Pro Val Tyr Arg Ser Pro Asn His Gly Thr 
            420                 425                 430         


Val Glu Leu Gln Gly Ser Gln Thr Ala Leu Tyr Arg Thr Gly Ser Val 
        435                 440                 445             


Gly Ile Gly Asn Leu Gln Arg Thr Ser Ser Gln Arg Ser Thr Leu Thr 
    450                 455                 460                 


Tyr Gln Arg Asn Asn Tyr Ala Leu Asn Thr Thr Ala Thr Tyr Ala Glu 
465                 470                 475                 480 


Pro Tyr Arg Pro Ile Gln Tyr Arg Val Gln Glu Cys Asn Tyr Asn Arg 
                485                 490                 495     


Leu Gln His Ala Val Pro Ala Asp Asp Gly Thr Thr Arg Ser Pro Ser 
            500                 505                 510         


Ile Asp Ser Ile Gln Lys Asp Pro Arg Glu Phe Ala Trp Arg Asp Pro 
        515                 520                 525             


Glu Leu Pro Glu Val Ile His Met Leu Gln His Gln Phe Pro Ser Val 
    530                 535                 540                 


Gln Ala Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Phe Gly Asp Asn 
545                 550                 555                 560 


Lys Val Lys Met Glu Val Cys Arg Leu Gly Gly Ile Lys His Leu Val 
                565                 570                 575     


Asp Leu Leu Asp His Arg Val Leu Glu Val Gln Lys Asn Ala Cys Gly 
            580                 585                 590         


Ala Leu Arg Asn Leu Val Phe Gly Lys Ser Thr Asp Glu Asn Lys Ile 
        595                 600                 605             


Ala Met Lys Asn Val Gly Gly Ile Pro Ala Leu Leu Arg Leu Leu Arg 
    610                 615                 620                 


Lys Ser Ile Asp Ala Glu Val Arg Glu Leu Val Thr Gly Val Leu Trp 
625                 630                 635                 640 


Asn Leu Ser Ser Cys Asp Ala Val Lys Met Thr Ile Ile Arg Asp Ala 
                645                 650                 655     


Leu Ser Thr Leu Thr Asn Thr Val Ile Val Pro His Ser Gly Trp Asn 
            660                 665                 670         


Asn Ser Ser Phe Asp Asp Asp His Lys Ile Lys Phe Gln Thr Ser Leu 
        675                 680                 685             


Val Leu Arg Asn Thr Thr Gly Cys Leu Arg Asn Leu Ser Ser Ala Gly 
    690                 695                 700                 


Glu Glu Ala Arg Lys Gln Met Arg Ser Cys Glu Gly Leu Val Asp Ser 
705                 710                 715                 720 


Leu Leu Tyr Val Ile His Thr Cys Val Asn Thr Ser Asp Tyr Asp Ser 
                725                 730                 735     


Lys Thr Val Glu Asn Cys Val Cys Thr Leu Arg Asn Leu Ser Tyr Arg 
            740                 745                 750         


Leu Glu Leu Glu Val Pro Gln Ala Arg Leu Leu Gly Leu Asn Glu Leu 
        755                 760                 765             


Asp Asp Leu Leu Gly Lys Glu Ser Pro Ser Lys Asp Ser Glu Pro Ser 
    770                 775                 780                 


Cys Trp Gly Lys Lys Lys Lys Lys Lys Lys Arg Thr Pro Gln Glu Asp 
785                 790                 795                 800 


Gln Trp Asp Gly Val Gly Pro Ile Pro Gly Leu Ser Lys Ser Pro Lys 
                805                 810                 815     


Gly Val Glu Met Leu Trp His Pro Ser Val Val Lys Pro Tyr Leu Thr 
            820                 825                 830         


Leu Leu Ala Glu Ser Ser Asn Pro Ala Thr Leu Glu Gly Ser Ala Gly 
        835                 840                 845             


Ser Leu Gln Asn Leu Ser Ala Gly Asn Trp Lys Phe Ala Ala Tyr Ile 
    850                 855                 860                 


Arg Ala Ala Val Arg Lys Glu Lys Gly Leu Pro Ile Leu Val Glu Leu 
865                 870                 875                 880 


Leu Arg Met Asp Asn Asp Arg Val Val Ser Ser Val Ala Thr Ala Leu 
                885                 890                 895     


Arg Asn Met Ala Leu Asp Val Arg Asn Lys Glu Leu Ile Gly Lys Tyr 
            900                 905                 910         


Ala Met Arg Asp Leu Val Asn Arg Leu Pro Gly Gly Asn Gly Pro Ser 
        915                 920                 925             


Val Leu Ser Asp Glu Thr Met Ala Ala Ile Cys Cys Ala Leu His Glu 
    930                 935                 940                 


Val Thr Ser Lys Asn Met Glu Asn Ala Lys Ala Leu Ala Asp Ser Gly 
945                 950                 955                 960 


Gly Ile Glu Lys Leu Val Asn Ile Thr Lys Gly Arg Gly Asp Arg Ser 
                965                 970                 975     


Ser Leu Lys Val Val Lys Ala Ala Ala Gln Val Leu Asn Thr Leu Trp 
            980                 985                 990         


Gln Tyr Arg Asp Leu Arg Ser Ile  Tyr Lys Lys Asp Gly  Trp Asn Gln 
        995                 1000                 1005             


Asn His  Phe Ile Thr Pro Val  Ser Thr Leu Glu Arg  Asp Arg Phe 
    1010                 1015                 1020             


Lys Ser  His Pro Ser Leu Ser  Thr Thr Asn Gln Gln  Met Ser Pro 
    1025                 1030                 1035             


Ile Ile  Gln Ser Val Gly Ser  Thr Ser Ser Ser Pro  Ala Leu Leu 
    1040                 1045                 1050             


Gly Ile  Arg Asp Pro Arg Ser  Glu Tyr Asp Arg Thr  Gln Pro Pro 
    1055                 1060                 1065             


Met Gln  Tyr Tyr Asn Ser Gln  Gly Asp Ala Thr His  Lys Gly Leu 
    1070                 1075                 1080             


Tyr Pro  Gly Ser Ser Lys Pro  Ser Pro Ile Tyr Ile  Ser Ser Tyr 
    1085                 1090                 1095             


Ser Ser  Pro Ala Arg Glu Gln  Asn Arg Arg Leu Gln  His Gln Gln 
    1100                 1105                 1110             


Leu Tyr  Tyr Ser Gln Asp Asp  Ser Asn Arg Lys Asn  Phe Asp Ala 
    1115                 1120                 1125             


Tyr Arg  Leu Tyr Leu Gln Ser  Pro His Ser Tyr Glu  Asp Pro Tyr 
    1130                 1135                 1140             


Phe Asp  Asp Arg Val His Phe  Pro Ala Ser Thr Asp  Tyr Ser Thr 
    1145                 1150                 1155             


Gln Tyr  Gly Leu Lys Ser Thr  Thr Asn Tyr Val Asp  Phe Tyr Ser 
    1160                 1165                 1170             


Thr Lys  Arg Pro Ser Tyr Arg  Ala Glu Gln Tyr Pro  Gly Ser Pro 
    1175                 1180                 1185             


Asp Ser  Trp Val 
    1190         


<210>  14
<211>  4604
<212>  DNA
<213>  Homo sapiens

<400>  14
tccggggctg agtccgcgtc gacgccggcc gcggaggcgg caccatgggc aaggggtaga     60

ggggcaagtt ggccaccgcc gccgccgggg gtggtgggag agccgctccg ggggcggggg    120

ccggtggggg agggaggggc gggcagccgc gccgccgcgg cactttttta attttttcgg    180

gtgccgcagc ggcgacccct cggcgccgat gtccctgatc cctggagcga cgacggccgc    240

tgcctaagct ggaaagagga atgccagctc ctgagcaggc ctcattggtg gaggaggggc    300

aaccacagac ccgccaggaa gctgcctcca ctggcccagg catggaaccc gagaccacag    360

ccaccactat tctagcatcc gtgaaggagc aggagcttca gtttcagcga ctcacccgag    420

aactggaagt ggaaaggcag attgttgcca gtcagctaga aagatgtagg cttggagcag    480

aatcaccaag catcgccagc accagctcaa ctgagaagtc atttccttgg agatcaacag    540

acgtgccaaa tactggtgta agcaaaccta gagtttctga cgctgtccag cccaacaact    600

atctcatcag gacagagcca gaacaaggaa ccctctattc accagaacag acatctctcc    660

atgaaagtga gggatcattg ggtaactcaa gaagttcaac acaaatgaat tcttattccg    720

acagtggata ccaggaagca gggagtttcc acaacagcca gaacgtgagc aaggcagaca    780

acagacagca gcattcattc ataggatcaa ctaacaacca tgtggtgagg aattcaagag    840

ctgaaggaca aacactggtt cagccatcag tagccaatcg ggccatgaga agagttagtt    900

cagttccatc tagagcacag tctccttctt atgttatcag cacaggcgtg tctccttcaa    960

gggggtctct gagaacttct ctgggtagtg gatttggctc tccgtcagtg accgaccccc   1020

gacctctgaa ccccagtgca tattcctcca ccacattacc tgctgcacgg gcagcctctc   1080

cgtactcaca gagacccgcc tccccaacag ctatacggcg gattgggtca gtcacctccc   1140

ggcagacctc caatcccaac ggaccaaccc ctcaatacca aaccaccgcc agagtggggt   1200

ccccactgac cctgacggat gcacagactc gagtagcttc cccatcccaa ggccaggtgg   1260

ggtcgtcgtc ccccaaacgc tcagggatga ccgccgtacc acagcatctg ggaccttcac   1320

tgcaaaggac tgttcatgac atggagcaat tcggacagca gcagtatgac atttatgaga   1380

ggatggttcc acccaggcca gacagcctga caggcttacg gagttcctat gctagtcagc   1440

atagtcagct tgggcaagac cttcgttctg ccgtgtctcc cgacttgcac attactccta   1500

tatatgaggg gaggacctat tacagcccag tgtaccgcag cccaaaccat ggaactgtgg   1560

agctccaagg atcgcagacg gcgttgtatc gcacaggttc agtaggtatt ggaaatctac   1620

aaaggacatc cagccaacga agtaccctta cataccaaag aaataattat gctctgaaca   1680

caacagctac ctacgcggag ccctacaggc ctatacaata ccgagtgcaa gagtgcaatt   1740

ataacaggct tcagcatgca gtgccggctg atgatggcac cacaagatcc ccatcaatag   1800

acagcattca gaaggacccc agggagtttg cctggcgtga tcctgagttg cctgaggtca   1860

ttcacatgct tcagcaccag ttcccatctg ttcaggcaaa tgcagcggcc tacctgcagc   1920

acctgtgctt tggtgacaac aaagtgaaga tggaggtgtg taggttaggg ggaatcaagc   1980

atctggttga ccttctggac cacagagttt tggaagttca gaagaatgct tgtggtgccc   2040

ttcgaaacct cgtttttggc aagtctacag atgaaaataa aatagcaatg aagaatgttg   2100

gtgggatacc tgccttgttg cgactgttga gaaaatctat tgatgcagaa gtaagggagc   2160

ttgttacagg agttctttgg aatttatcct catgtgatgc tgtaaaaatg acaatcattc   2220

gagatgctct ctcaacctta acaaacactg tgattgttcc acattctgga tggaataact   2280

cttcttttga tgatgatcat aaaattaaat ttcagacttc actagttctg cgtaacacga   2340

caggttgcct aaggaacctc agctccgcgg gggaagaagc tcggaagcaa atgcggtcct   2400

gcgaggggct ggtagactca ctgttgtatg tgatccacac gtgtgtgaac acatccgatt   2460

acgacagcaa gacggtggag aactgcgtgt gcaccctgag gaacctgtcc tatcggctgg   2520

agctggaggt gccccaggcc cggttactgg gactgaacga attggatgac ttactaggaa   2580

aagagtctcc cagcaaagac tctgagccaa gttgctgggg gaagaagaag aaaaagaaaa   2640

agaggactcc gcaagaagat caatgggatg gagttggtcc tatcccagga ctgtcgaagt   2700

cccccaaagg ggttgagatg ctgtggcacc catcggtggt aaaaccatat ctgactcttc   2760

tagcagaaag ttccaaccca gccaccttgg aaggctctgc agggtctctc cagaacctct   2820

ctgctggcaa ctggaagttt gcagcatata tccgggcggc cgtccgaaaa gaaaaggggc   2880

tccccatcct tgtggagctt ctgagaatgg ataacgatag agttgtttct tccgtggcaa   2940

cagccttgag gaatatggca ctagatgttc gcaacaagga gctcataggc aaatacgcca   3000

tgcgagacct ggtcaaccgg ctccccggcg gcaatggccc cagtgtcttg tctgatgaga   3060

ccatggcagc catctgctgt gctctgcacg aggtcaccag caaaaacatg gagaacgcaa   3120

aagccctggc cgactcagga ggcatagaga agctggtgaa cataaccaaa ggcaggggcg   3180

acagatcatc tctgaaagtg gtgaaggcag cagcccaggt cttgaataca ttatggcaat   3240

atcgggacct ccggagcatt tataaaaagg atgggtggaa tcagaaccat tttattacac   3300

ctgtgtcgac attggagcga gaccgattca aatcacatcc ttccttgtct accaccaacc   3360

aacagatgtc acccatcatt cagtcagtcg gcagcacctc ttcctcacca gcactgttag   3420

gaatcagaga ccctcgctct gaatacgata ggacccagcc acctatgcag tattacaata   3480

gccaagggga tgccacacat aaaggcctgt accctggctc cagcaaacct tcaccaattt   3540

acatcagttc ctattcctca ccagcaagag aacaaaatag acggctacag catcaacagc   3600

tgtattatag tcaagatgac tccaacagaa agaactttga tgcatacaga ttgtatttgc   3660

agtctcctca tagctatgaa gatccttatt ttgatgaccg agttcacttt ccagcttcta   3720

ctgattactc aacacagtat ggactgaaat cgaccacaaa ttatgtagac ttttattcca   3780

ctaaacgacc ttcttataga gcagaacagt acccagggtc cccagactca tgggtgtagc   3840

atcaagatgc ccaacagagg aactctttct ttctaacctt gttcagattg aggtgaaaag   3900

tccatcttgc tgatttgatg attgaaatgt gaaagtgaag tggaaggaat gaatgaagtg   3960

tgtttttttt ttcttttttg aggaattatc agggaagtga ggaaatgttt gggagaggac   4020

tttctaagct ctatttaggt gttagatcta attacttata gattctgtag tctggtgaag   4080

gtgtgggtga cgtgatgaga ggtttgagaa atgggtgaaa tgaaatgggg gatatgtagg   4140

tcaaatcaaa ttaaagatga tttttttaat gtgaataaag ttatgttctg atagtttgta   4200

cagaaaaaat aaaatggatg cccatgtttt attgctatta ctaaatgtca agattgtatg   4260

ctattatgtc ttgtaaattt cttttgttgg tgtaaatatg gaaatgccac attggttaag   4320

tgccatcatt tgtaatgcaa tgtgtcactt gaaaagagat ttgaagaaac tgacaacttc   4380

aaaaacaaat gagaagccca aggaactgtg agcaattaaa agcaaaccgc gacacccttt   4440

gtctccacca cacatagtgt actttggaag cacaacgtcc aggctggtac cgcagcgcca   4500

tgcccattcc tcgcctcgtt cataggacac ttcactgcca ttttctattc acataaaaga   4560

aaaataaatg tggaaatttc atccttggaa aaaaaaaaaa aaaa                    4604


<210>  15
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Arg Leu Leu Pro Arg Leu Leu Leu Leu Leu Leu Leu Val Phe Pro 
1               5                   10                  15      


Ala Thr Val Leu Phe Arg Gly Gly Pro Arg Gly Leu Leu Ala Val Ala 
            20                  25                  30          


Gln Asp Leu Thr Glu Asp Glu Glu Thr Val Glu Asp Ser Ile Ile Glu 
        35                  40                  45              


Asp Glu Asp Asp Glu Ala Glu Val Glu Glu Asp Glu Pro Thr Asp Leu 
    50                  55                  60                  


Val Glu Asp Lys Glu Glu Glu Asp Val Ser Gly Glu Pro Glu Ala Ser 
65                  70                  75                  80  


Pro Ser Ala Asp Thr Thr Ile Leu Phe Val Lys Gly Glu Asp Phe Pro 
                85                  90                  95      


Ala Asn Asn Ile Val Lys Phe Leu Val Gly Phe Thr Asn Lys Gly Thr 
            100                 105                 110         


Glu Asp Phe Ile Val Glu Ser Leu Asp Ala Ser Phe Arg Tyr Pro Gln 
        115                 120                 125             


Asp Tyr Gln Phe Tyr Ile Gln Asn Phe Thr Ala Leu Pro Leu Asn Thr 
    130                 135                 140                 


Val Val Pro Pro Gln Arg Gln Ala Thr Phe Glu Tyr Ser Phe Ile Pro 
145                 150                 155                 160 


Ala Glu Pro Met Gly Gly Arg Pro Phe Gly Leu Val Ile Asn Leu Asn 
                165                 170                 175     


Tyr Lys Asp Leu Asn Gly Asn Val Phe Gln Asp Ala Val Phe Asn Gln 
            180                 185                 190         


Thr Val Thr Val Ile Glu Arg Glu Asp Gly Leu Asp Gly Glu Thr Ile 
        195                 200                 205             


Phe Met Tyr Met Phe Leu Ala Gly Leu Gly Leu Leu Val Ile Val Gly 
    210                 215                 220                 


Leu His Gln Leu Leu Glu Ser Arg Lys Arg Lys Arg Pro Ile Gln Lys 
225                 230                 235                 240 


Val Glu Met Gly Thr Ser Ser Gln Asn Asp Val Asp Met Ser Trp Ile 
                245                 250                 255     


Pro Gln Glu Thr Leu Asn Gln Ile Asn Lys Ala Ser Pro Arg Arg Leu 
            260                 265                 270         


Pro Arg Lys Arg Ala Gln Lys Arg Ser Val Gly Ser Asp Glu 
        275                 280                 285     


<210>  16
<211>  9874
<212>  DNA
<213>  Homo sapiens

<400>  16
cccacctctc cgcgctgagc agccacgtcg gcggcggtcc ctggtccagg gaggggcgtg     60

gcaaaggccc gtgcgcggta cgtgtcccgc ccctcgctgc ccggagcccg gatgaagagt    120

aacgccatta ccgccggagc cgccgagagc cttagccgac ggaaactgga cactggaccg    180

gcagcgccat gagactcctc ccccgcttgc tgctgcttct cttactcgtg ttccctgcca    240

ctgtcttgtt ccgaggcggc cccagaggct tgttagcagt ggcacaagat cttacagagg    300

atgaagaaac agtagaagat tccataattg aggatgaaga tgatgaagcc gaggtagaag    360

aagatgaacc cacagatttg gtagaagata aagaggaaga agatgtgtct ggtgaacctg    420

aagcttcacc gagtgcagat acaactatac tgtttgtaaa aggagaagat tttccagcaa    480

ataacattgt gaagttcctg gtaggcttta ccaacaaggg tacagaagat tttattgttg    540

aatccttaga tgcctcattc cgttatcctc aggactacca gttttatatc cagaatttca    600

cagctcttcc tctgaacact gtagtgccac cccagagaca ggcaactttt gagtactctt    660

tcattcctgc agagcccatg ggcggacgac catttggttt ggtcatcaat ctgaactaca    720

aagatttgaa cggcaatgta ttccaagatg cagtcttcaa tcaaacagtt acagttattg    780

aaagagagga tgggttagat ggagaaacaa tctttatgta tatgttcctt gctggtcttg    840

ggcttctggt tattgttggc cttcatcaac tcctagaatc tagaaagcgt aagagaccca    900

tacagaaagt agaaatgggt acatcaagtc agaatgatgt tgacatgagt tggattcctc    960

aggaaacatt gaatcaaatc aataaagctt caccaagaag gttgcccagg aaacgggcac   1020

agaagagatc agtgggatct gatgagtaaa tgttcctttg tgcaacaatt cggtctttac   1080

ttaacctgcc ctaatatttt tcggcctgat gggaattagt gcagagaagc catgtcacca   1140

tagaaggcaa ctcctacttg tgtgtggact gagcaatcag agtctgtggc gataatattg   1200

ctgaaaatgc actgcattca tttttctaaa gtaacaaatt tggttttttt ttaaaccatt   1260

aaaatctatg tgtgtgcgtg tgtatgtatg tgagcagttg gtcttaccag aatcattgtt   1320

gaactacctg aaacaagtct ttagaatact aaatataatg ctgttgtctc ttcctttttg   1380

acattttctg attttttccc ccaaaactca gttaatattt acccactatg attattgatg   1440

tcctgccttg aacagtttta aagaaaacaa tttttggaat agctcaaatt tcaattgatg   1500

gcacaaatca gcattttgtt gttgttactg tattacaatt agtattctaa aggcagaagc   1560

agaagtagct gctttttagc aatagaattg tttcagtatt ttgctgctgt ttaatgcgca   1620

tcttcagaaa acttcccagt ggcttcaagg aatttgggga tctctctggc aacaaattgt   1680

gaaacatgaa atttctgctg actttaatat atgaaaccta atcctacccc cttttttaac   1740

aaaaagaaac tagtacattt gtgaaaattg tgttgtgttg tccattgttg ctctagttct   1800

gacccagagg tagctctgga gtgattttag acctactcac tcagttgtgt gtaggttttt   1860

ttgttttgtt ttgagagaga atttttctct ccttaataga agcatccttt ttaaagagaa   1920

gttgccttgg tccacacact aagcagaaaa ccaagttatc aggacagaga tatttcccag   1980

ttactcctaa tcaatgaaga aagtgagttg gatattttta aagcagttaa ctaatttttt   2040

cttacctaat cttttgggag ttttgcttgt tgatataacc tttttagtta acctgaaaga   2100

ttccaaaaat tgttcttaag tgcttgagac tggaaccaaa attaaattgt acttcataaa   2160

atcctcttat agagttactc ttgccctaga ttgtaaatta agtttggcat tattgtcaga   2220

ctggatggag ggtgaagtaa aatagtatga acaattaaga ggctctcccc ctcttgtctt   2280

taagccatat tctcctacat gtattttata agaaaatgtt aagtcaaatt ttagtggctc   2340

tttaattcct gacctcttca ttctcctttt cagtataacc tcccctatgc tcatgcccac   2400

acagacaaaa aaacaaaacg aaatacacac agaaaaaagt ctttccaaac tgtttaagta   2460

tttaaacatc tgagccaaag cagatagaag ttattgtata attgttaatc actttgcaaa   2520

taggggctat caaattacct atattggcat tgctggatta taaactctat atctgtaata   2580

taaagtgttt gagtttttaa ttgggctgtt atgatcagta gttgattttg agaaagctct   2640

atgagctcta agtaactgca tggttttttg tttaatgtaa tataggagac ccttcacatt   2700

cccaaggaat atattccaaa acatttttgt gaatatctaa gtttgtgaaa ctactagggc   2760

atgatacagt aaggtgtaat tacagaattt acgaaatgta aatggcctct acagagtttt   2820

atggaatacc tggtactaac gtaggcagct gcaaaaccac actgagttac agctgtcagc   2880

cctcctcatt cctaaataac ttgccttaca tatcagccct cccacttctg aagttcaaat   2940

tagtgcctcg gaaatgtaga atttattatt tgtcattttt ttttttttag catagattga   3000

gaacagttga actcttaaat cctcagatgc caggggtctg ctctagcatc agtaagtatt   3060

tagcagaaac taactccgta atgaatggaa ttcaattcca cacatggttt gttcaagcac   3120

acttaataag tagcctattt tttaaatgtc tttttaaaat gtaaatattt ggatgaagtt   3180

tttctttgtt ttgatatatt catttgctac accaactatg ttttcagaat tcatcttttg   3240

aacaacttgg tttcagaata tgtaaaatga ctttaaggat cttgtgtatc aaacctatcc   3300

ccggatgtgt gagaataatg tgttcataaa gcatggatct cgctttggtt gtatagcttc   3360

ctcatttact tcatggtctt acatagctgg tgactttcag ggctaatctg ccctctaaag   3420

cattgtccca ggagaggaaa aggaaatggg acctcagaag tagaagcctc agggaaggag   3480

taaagtagaa atcagaagaa aagaagcttc acttgatagt aataaggttt ttaacttcaa   3540

gtaccttcag aaaatgtgat tttgataaga ggaaagggca aatttagacc ttaaaaaata   3600

tggaagaact actgccttaa aagtgcattt gtggcacatc agcctagaac tgtatcatgg   3660

ctgtgctggg gagaagtaaa tggtggtaat gtaacattgc cacctttact taatgatgtg   3720

ttattttcga ggtacagtag atcaatatag taataggcga gcctcatata tagcattcat   3780

cttgtacaat gatatccata cccttgatat gaaggaaaat tgacttggtt tgtgcatttg   3840

aatactgaaa taatttttta aaactcagtg acacatacca tctcttgcca agactagacc   3900

ctgtatttta gttcctaaat tagatgttta aatttaaaaa cattttcaga tgtacttaag   3960

tacttccata gtactttttt tttttttttt ttttttgccc cctgagacgg agtctctgtg   4020

tcacccaggc tggagtgcag tggtgcgatc tcggctcact gcaacttctg cctcttgggt   4080

tcaagcagtt ctccctgtct cagcctcctg agtagcttgg attacaggcg cccgtcaccg   4140

cacctgccta atttttgcat ttttagtaga gacggggttt cgtcatttgg ccaggctggt   4200

cttgaactcc tgaccacagg tgatacgcct gccttggcct cccaaagtgt gctgggatta   4260

caggcgtgag ccactgtgcc cggcccactg ttcacttttt gaatggcatc attttatagc   4320

tgtagaacta aaatcaatgt ttgccccaat tttcttaagt aaaactctac tttgagctct   4380

tacctccaac ttagtaaaaa gcagcttcac acacaaacaa gattcttact ggtggaatgt   4440

taggtttcgt tgttaagtta atctgtctat aagctcatcc ttagaggata tttgaggagg   4500

aagaacacct tgcagctgac ttgcaaacat ctaaataatt tatttcgggt gcttatgaat   4560

gttactaatg gattttgtat gaatttttat cccttttcat ttatacaaaa acctgggctt   4620

ttatgttaat tatatcatct gaggttctaa ggtttttttt ttagattttg aaatttaggg   4680

ataatagctc ttaggtttgg gtaccacttt gctgcagttt aagaaagggg gaagggaact   4740

catttattaa acatcaatca cgtgctgtgt tctgtttgtt ttctagtcat catatcacac   4800

acctttacga cagctcactg aaggaaggtg atactgttcc cattttgtag atggaataga   4860

caaaacctga atttaagtag cttgctcaag gttccatatt gaatatggaa agttcaaatc   4920

atctcagtaa tgaatatacc atatatactt gctgtattgt atctatgata attcagttac   4980

ccacaatacc cttttaaatt tctgttaatg acataccttt aaatgtctcc ttgatgaaca   5040

gaatcatggt ctttaaaaac attttcatgg gttgattgca ttttcaagct ctaaaggatt   5100

gaaagataaa tcttcacgtt aaaggtaaga gtgaagtatc tgctcttggg ttacagaacc   5160

agatagtact agaactaaga ttacagggta aagctgcttt tatctttttt ctttttcttt   5220

ttcttttttt ttttgacatg gggtctcact gtattgccca ggctggaatg cagtggcatg   5280

atctcagctc acggcagcct ctgcctcttg ggctcaagcg attctcctgc ttcagctttc   5340

caagtatttg ggaccacagg cgcacaccac aggcctggct aatgtttttg ttttgttttt   5400

ggtagagacg gggtttcacc atgttgccag gctggtctcg aactcctgag ctcaagtgat   5460

tcacccacct tggcctcaca aagtgtcagg cttacaggcg tgagccactg cgcccggctc   5520

acagggtaag gcttctgtct ggtgtgttgt attacggatt ttgcttaata ggcacagtga   5580

ggcattaaaa agaaaattca gtatgcctgt agaaaggata atccttgttt aaagtctcca   5640

aattgcagtc aaagatgttt tgactgtgcc tttttttgtt cccctgctgt cccttatgta   5700

gacttctgtc agtacccatg gcagcctgtc atcttgttga catctccttc tggactgtga   5760

gctctgtatc tggcttgttt ttcatcccca gcttctagtt cacaattagg tagaacccta   5820

ttactctttg aagaaggaac aagaaaatgt gggccagttt tcatttgcca ttcttccatg   5880

tgagttagta tggttcgtaa gtattcctgg tgatacgcta gtattggcaa ttctgtgagg   5940

ttgaacaaag gggtggtatg gtgtgctagc gtgggaatta ggagacctct gggtcttgac   6000

agtgccctgg ccactaagca aaggcagttc atccttggag tctcaatgtg cttttttgtt   6060

aattgagata tgcttgaagt atcagcccta aatagtctga ttctgtgacc tacaaaccct   6120

tacttaattc agtgttacta taaatgattc ttcccttaaa cctacttttt acttagcaaa   6180

agagaaaaaa aaaaaaagga aacgctcatg tcaggctgcc tgggtttgaa ccccagatcc   6240

cctcttagtt ggaggcaagt tgtatgatgc ttcagctttt ggttcctgcc tcctaaggtt   6300

gttaggagtt actgtgtgta gctgcttaga acattgcctg ggtctcagta agccgcttaa   6360

gtgactgctc tcattttcgc tgtaaagcac catactgtaa taacatccca tgaagcatgg   6420

ggcggggaag agtatatggt accttatgga ctttgatgtg gtggggtagt aggtaaattc   6480

tgaatatgta agctacatag tattcttttt gtaactaaag gataaaagtt ttaagatggg   6540

catgtaatat ggctagcact ggattttaat gatgagccag agtaataagg ctggcaaggg   6600

gagtttttgt tttgtaataa atctcttaca cctgcacatc cagttctttt taaaaacacg   6660

tttgaagagg ctccatattt ctcagtgaag ctgttggggt tcatgttatt tttgaaaatc   6720

atcttgcaat ttatttcagc atcagactga accacccaaa gaaaattagt ctatttctga   6780

acagtttttt cagaaaccat attggtctga tcacccaaca tttatagaaa taggcgctta   6840

aggcctagag gcatttcaga aaggagaatg agaaatactg tggtcaagag tagtgttcag   6900

atggagaaca tcaagcatct gctctgccct tccacacaca tcctcatttc atcttcacaa   6960

ctgccctagg taaccttgtt atctgtaatg aaacagcctc aaggagcaca gaggcactca   7020

ctcctcacgt ttggtctgtt gccatttccg gcttggttgg aatagggtag gagccttttg   7080

gcagggagca cattctcagt aatgcagagt gcactcacct gggttctagc ttcaacactt   7140

aggatttgct tgatattttg tattctctga ggcactgcct gtatttgttt ctgctatcac   7200

agtccagagt caagcttcat ttataaagac tgggcagggc atggtggctc actcctgtaa   7260

ttccagcact ttgggaggct gaggtgggtg gatcacttta ggtcaggagt tcaagaccag   7320

cctggccaac atggtgaaac cccatctcta ctaaaaaata caaaaaggcc gggcacggtg   7380

gctcacacct gtaatcccaa cactttggga ggccaaggtg ggcagaacac ctgaggtcag   7440

gagttcaaga ccatcctggc gaacatagtg aaacctcgcc tctactaaaa atacaaaaat   7500

tagccaggtg tggtggtgca tgcctgtaat cccagctact tgggaggctg aggcaggaga   7560

attgcttaaa cctgggaggt ggagattgtg gtgagctgag atcgtgccac tgcactccag   7620

cctgggagat agaacgagac tccatctcaa aaaagaacaa aaacaattag ccgagcgagg   7680

tggtgcacgc ctgtaatccc agctactcat gaggctgagg caggagaatc acttgaaccc   7740

aggaggagga ggttgtagtg agtcaaggtt gcaccactgc actccagcct gggtgacaga   7800

gtgagactgt ctcaaaaaat aagtacataa ataataagta aaagctacta acaattaaaa   7860

aataaataaa taaagacaag actgtctgga aaatggctct cctaaaagga ccagttgcca   7920

tcatccacag tggaagattc aaagcagttg gtccttggta cgtatgagaa gcggatttca   7980

ttcccttgaa ttctacagag cagtttatta gagtgaatgc attttaaggc cttgcatttg   8040

atatgtcatc cagttcataa tcaagttgcc tttttctggc taaaacataa tgattatgta   8100

tttttctcat ttggtcctac aagctgctgg ccctttgtcc ctccactgtg ggaatcagat   8160

ctagaggagg ctgagcctgc agacacagca gtggccaaaa ggtcactcta agtgttttgt   8220

cttgactcct tacttgaagt ccacccagct agcacacatc tggtttatac tgaagccccc   8280

tgcctagaaa tactcatttc aggaaccacc agtaagcatc tgtgaccaca caggcttttt   8340

gactgatggc ttcccggatc tggtttcaag ggataacccc gtctgtgtgc atctatggtc   8400

ttctctctac agcgaggact ttgcagtgct gcttgtggtc cacacaaggg gctcagagct   8460

gagtctgaac tgcttcatgg tcaccagctc ctgtcccttc cagtcttgag aggctttttt   8520

ctccagatgg aacctttcct tcccgccgtt ttctcggtct ctggctgttt ttctcttgtg   8580

cccgtctaat tggacacctc ctggcttcca tctctgtggt tctcctgcct cacttcctgt   8640

tctgttgttt ttccgttttg tcaaaatatc tcctatgttc ttggcttcct tttcgtcgcc   8700

aggttttcag ctttccttta gctcttcttc taatatggct tctgcccaca aaagcctgct   8760

ctgtcaggat ctcatggttc tccacttgcc agaaccttct tcagcctcag ttcctcggcc   8820

tcaacttgta cgtttaaccc attgaccacc accccccaaa ttcaccttca tttctttgac   8880

cctgctcctc actccttttc tgttgaggaa tctgttgact aactccaggc tcactcaggc   8940

tcaccgtcct gctctctgca ccagcctttc cagagcgtgc cagttctcat ggcttcatct   9000

gttaactgtt gatcacttca gtcctgattt ttagacctaa atggtttcct taacgccatt   9060

ctaactgcct gtgactcatt ttcacttaca gtgtttattg taacgccaaa ccaacaaatc   9120

acaggtgctt gcttctctcc ataaatctcc ccagtctaac tttttgtcat tcaacatgac   9180

tcgtttatcc aacctgaaat cgcatatagc cccaagtatg gtgttttgta cacaggtatt   9240

taataagtga cttccagttt tggctctgct atgaataaaa agagatttca gttctcttca   9300

ctttgaaatc taacaactca gagaacattg aagaaattgg aatttagttg ggatgaaata   9360

cttgtggttt aaaatatttc tgttcatatt ttctaatttg ttgccggagg tcttgggttt   9420

tctatttgag tgcttgcaaa ctcaatgtga tttctgtcag catatcttag gtttgtttgt   9480

tatgaaactt atgcagtgtg aggttctatc tgaaaatgtt atttagctat cttctgggac   9540

tatttaatga aagtggggtc atgaatcctt aaaattcttg tgcagctttg agaaacattt   9600

ctgttatttg ggtatcagtt tgtaagtgtg gtaaagccaa gatggaaacg agcactttgc   9660

tttcttggtt gttgttactg gtctaacctc ctgcttgaac tagtctgctg tcctgtcaaa   9720

tgcatctttt tatttacatg tcccttaaat taaagctgat catgaaagta tttgtgtgca   9780

acatgaaatg ttttctaaag taccagtgca tattcctgct tggtctcaag acgcacgagg   9840

aatccaaaat agaagcaaaa aaaaaaaaaa aaaa                               9874


<210>  17
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Glu Leu Ser Glu Glu Ala Leu Leu Ser Val Leu Pro Thr Ile 
1               5                   10                  15      


Arg Val Pro Lys Ala Gly Asp Arg Val His Lys Asp Glu Cys Ala Phe 
            20                  25                  30          


Ser Phe Asp Thr Pro Glu Ser Glu Gly Gly Leu Tyr Ile Cys Met Asn 
        35                  40                  45              


Thr Phe Leu Gly Phe Gly Lys Gln Tyr Val Glu Arg His Phe Asn Lys 
    50                  55                  60                  


Thr Gly Gln Arg Val Tyr Leu His Leu Arg Arg Thr Arg Arg Pro Lys 
65                  70                  75                  80  


Glu Glu Asp Pro Ala Thr Gly Thr Gly Asp Pro Pro Arg Lys Lys Pro 
                85                  90                  95      


Thr Arg Leu Ala Ile Gly Val Glu Gly Gly Phe Asp Leu Ser Glu Glu 
            100                 105                 110         


Lys Phe Glu Leu Asp Glu Asp Val Lys Ile Val Ile Leu Pro Asp Tyr 
        115                 120                 125             


Leu Glu Ile Ala Arg Asp Gly Leu Gly Gly Leu Pro Asp Ile Val Arg 
    130                 135                 140                 


Asp Arg Val Thr Ser Ala Val Glu Ala Leu Leu Ser Ala Asp Ser Ala 
145                 150                 155                 160 


Ser Arg Lys Gln Glu Val Gln Ala Trp Asp Gly Glu Val Arg Gln Val 
                165                 170                 175     


Ser Lys His Ala Phe Ser Leu Lys Gln Leu Asp Asn Pro Ala Arg Ile 
            180                 185                 190         


Pro Pro Cys Gly Trp Lys Cys Ser Lys Cys Asp Met Arg Glu Asn Leu 
        195                 200                 205             


Trp Leu Asn Leu Thr Asp Gly Ser Ile Leu Cys Gly Arg Arg Tyr Phe 
    210                 215                 220                 


Asp Gly Ser Gly Gly Asn Asn His Ala Val Glu His Tyr Arg Glu Thr 
225                 230                 235                 240 


Gly Tyr Pro Leu Ala Val Lys Leu Gly Thr Ile Thr Pro Asp Gly Ala 
                245                 250                 255     


Asp Val Tyr Ser Tyr Asp Glu Asp Asp Met Val Leu Asp Pro Ser Leu 
            260                 265                 270         


Ala Glu His Leu Ser His Phe Gly Ile Asp Met Leu Lys Met Gln Lys 
        275                 280                 285             


Thr Asp Lys Thr Met Thr Glu Leu Glu Ile Asp Met Asn Gln Arg Ile 
    290                 295                 300                 


Gly Glu Trp Glu Leu Ile Gln Glu Ser Gly Val Pro Leu Lys Pro Leu 
305                 310                 315                 320 


Phe Gly Pro Gly Tyr Thr Gly Ile Arg Asn Leu Gly Asn Ser Cys Tyr 
                325                 330                 335     


Leu Asn Ser Val Val Gln Val Leu Phe Ser Ile Pro Asp Phe Gln Arg 
            340                 345                 350         


Lys Tyr Val Asp Lys Leu Glu Lys Ile Phe Gln Asn Ala Pro Thr Asp 
        355                 360                 365             


Pro Thr Gln Asp Phe Ser Thr Gln Val Ala Lys Leu Gly His Gly Leu 
    370                 375                 380                 


Leu Ser Gly Glu Tyr Ser Lys Pro Val Pro Glu Ser Gly Asp Gly Glu 
385                 390                 395                 400 


Arg Val Pro Glu Gln Lys Glu Val Gln Asp Gly Ile Ala Pro Arg Met 
                405                 410                 415     


Phe Lys Ala Leu Ile Gly Lys Gly His Pro Glu Phe Ser Thr Asn Arg 
            420                 425                 430         


Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Ile Asn Met Val Glu 
        435                 440                 445             


Arg Asn Cys Arg Ser Ser Glu Asn Pro Asn Glu Val Phe Arg Phe Leu 
    450                 455                 460                 


Val Glu Glu Lys Ile Lys Cys Leu Ala Thr Glu Lys Val Lys Tyr Thr 
465                 470                 475                 480 


Gln Arg Val Asp Tyr Ile Met Gln Leu Pro Val Pro Met Asp Ala Ala 
                485                 490                 495     


Leu Asn Lys Glu Glu Leu Leu Glu Tyr Glu Glu Lys Lys Arg Gln Ala 
            500                 505                 510         


Glu Glu Glu Lys Met Ala Leu Pro Glu Leu Val Arg Ala Gln Val Pro 
        515                 520                 525             


Phe Ser Ser Cys Leu Glu Ala Tyr Gly Ala Pro Glu Gln Val Asp Asp 
    530                 535                 540                 


Phe Trp Ser Thr Ala Leu Gln Ala Lys Ser Val Ala Val Lys Thr Thr 
545                 550                 555                 560 


Arg Phe Ala Ser Phe Pro Asp Tyr Leu Val Ile Gln Ile Lys Lys Phe 
                565                 570                 575     


Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Leu Asp Val Ser Ile Glu 
            580                 585                 590         


Met Pro Glu Glu Leu Asp Ile Ser Gln Leu Arg Gly Thr Gly Leu Gln 
        595                 600                 605             


Pro Gly Glu Glu Glu Leu Pro Asp Ile Ala Pro Pro Leu Val Thr Pro 
    610                 615                 620                 


Asp Glu Pro Lys Gly Ser Leu Gly Phe Tyr Gly Asn Glu Asp Glu Asp 
625                 630                 635                 640 


Ser Phe Cys Ser Pro His Phe Ser Ser Pro Thr Ser Pro Met Leu Asp 
                645                 650                 655     


Glu Ser Val Ile Ile Gln Leu Val Glu Met Gly Phe Pro Met Asp Ala 
            660                 665                 670         


Cys Arg Lys Ala Val Tyr Tyr Thr Gly Asn Ser Gly Ala Glu Ala Ala 
        675                 680                 685             


Met Asn Trp Val Met Ser His Met Asp Asp Pro Asp Phe Ala Asn Pro 
    690                 695                 700                 


Leu Ile Leu Pro Gly Ser Ser Gly Pro Gly Ser Thr Ser Ala Ala Ala 
705                 710                 715                 720 


Asp Pro Pro Pro Glu Asp Cys Val Thr Thr Ile Val Ser Met Gly Phe 
                725                 730                 735     


Ser Arg Asp Gln Ala Leu Lys Ala Leu Arg Ala Thr Asn Asn Ser Leu 
            740                 745                 750         


Glu Arg Ala Val Asp Trp Ile Phe Ser His Ile Asp Asp Leu Asp Ala 
        755                 760                 765             


Glu Ala Ala Met Asp Ile Ser Glu Gly Arg Ser Ala Ala Asp Ser Ile 
    770                 775                 780                 


Ser Glu Ser Val Pro Val Gly Pro Lys Val Arg Asp Gly Pro Gly Lys 
785                 790                 795                 800 


Tyr Gln Leu Phe Ala Phe Ile Ser His Met Gly Thr Ser Thr Met Cys 
                805                 810                 815     


Gly His Tyr Val Cys His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr 
            820                 825                 830         


Asn Asp Gln Lys Val Cys Ala Ser Glu Lys Pro Pro Lys Asp Leu Gly 
        835                 840                 845             


Tyr Ile Tyr Phe Tyr Gln Arg Val Ala Ser 
    850                 855             


<210>  18
<211>  3214
<212>  DNA
<213>  Homo sapiens

<400>  18
aggggagggg actgggaacg gtgggagccg ccgtgtgtgg agaagctgct gccggtgtca     60

tggcggagct gagtgaggag gcgctgctgt cagtattacc gacgatccgg gtccctaagg    120

ctggagaccg ggtccacaaa gacgagtgcg ccttctcctt cgacacgccg gagtctgagg    180

ggggcctcta catctgtatg aacacgtttc tgggctttgg gaaacagtat gtggagagac    240

atttcaataa gaccggccag cgagtctact tgcacctccg gcggacccgg cgcccgaaag    300

aggaggaccc tgctacaggc actggagacc caccccggaa gaagcccacg cggctggcta    360

ttggtgttga aggcggattt gaccttagcg aggagaagtt tgaattagac gaggatgtga    420

agattgtcat tttgccagat tacctggaga ttgcccggga tggactgggg ggactgcctg    480

acattgtcag agatcgggtg accagtgcag tggaggccct actgtcggcc gactcagcct    540

cccgcaagca ggaggtgcag gcatgggatg gggaagtacg gcaggtgtct aagcatgcct    600

tcagcctcaa gcagttggac aaccctgctc gaatccctcc ctgtggctgg aagtgctcca    660

agtgtgacat gagagagaac ctgtggctca acctgactga tggctccatc ctctgtgggc    720

gacgctactt cgatggcagt gggggcaaca accacgctgt ggagcactac cgagagacag    780

gctacccgtt agctgtcaag ctgggcacca tcacccctga tggagctgac gtgtactcat    840

atgatgagga tgacatggtc ctggacccca gcctggctga gcacctgtcc cacttcggca    900

tcgacatgct gaagatgcag aagacagaca agacgatgac tgagttggag atagacatga    960

accagcggat tggtgaatgg gagctgatcc aggagtcagg tgtgccactc aagcccctgt   1020

ttgggcctgg ctacacaggc atccggaacc tgggtaacag ctgctacctc aactctgtgg   1080

tccaggtgct cttcagcatc cctgacttcc agaggaagta tgtggataag ctggagaaga   1140

tcttccagaa tgccccgacg gaccctaccc aggatttcag cacccaggtg gccaagctgg   1200

gccatggcct tctctccggg gagtattcca agccagtacc ggagtcgggc gatggggagc   1260

gggtgccaga acagaaggaa gttcaagatg gcattgcccc tcggatgttc aaggccctca   1320

tcggcaaggg ccaccctgaa ttctccacca accggcagca ggatgcccag gagttcttcc   1380

ttcaccttat caacatggtg gagaggaatt gccggagctc tgaaaatcct aatgaagtgt   1440

tccgcttctt ggtggaggaa aagatcaagt gcctggccac agagaaggtg aagtacaccc   1500

agcgagttga ctacatcatg cagctgcctg tgcccatgga tgcagccctt aacaaagagg   1560

agcttctgga gtacgaggag aagaagcggc aagccgaaga ggagaagatg gcactgccag   1620

aactggttcg ggcccaggtg cccttcagct cttgcctgga ggcctacggg gcccctgagc   1680

aggtcgatga cttctggagc acggccctgc aggccaagtc agtagctgtc aagaccacac   1740

gatttgcctc attccctgac tacctggtca tccagatcaa gaagttcacc ttcggcttag   1800

actgggtgcc caagaaactg gatgtgtcca tcgagatgcc agaggagctc gacatctccc   1860

agttgagggg cacagggctg cagcccggag aggaggagct gccagacatt gccccacccc   1920

tggtcactcc ggatgagccc aaaggtagcc ttggtttcta tggcaacgaa gacgaagact   1980

ccttctgctc ccctcacttc tcctctccga catcgcccat gctggatgaa tcagtcatca   2040

tccagctggt ggagatggga ttccctatgg acgcctgccg caaagctgtc tactacacgg   2100

gcaacagcgg ggctgaggcc gccatgaact gggtcatgtc acacatggat gatccagatt   2160

ttgcaaaccc cctcatcctg cctggctcta gtgggccggg ctccacaagc gcagcagccg   2220

acccccctcc tgaggactgt gtgaccacca ttgtctccat gggcttctcc cgggaccagg   2280

ccttgaaagc gctgcgggcc acgaacaata gtttagaacg ggctgtggac tggatcttca   2340

gtcacattga cgacctggat gctgaagctg ccatggacat ctcagagggc cgctcagctg   2400

ccgactccat ctctgagtct gtgccagtgg gacctaaagt ccgggatggt cctggaaagt   2460

atcagctctt tgccttcatt agtcacatgg gcacctctac catgtgtggt cactacgtct   2520

gccacatcaa gaaagaaggc agatgggtga tctacaatga ccagaaagtg tgtgcctccg   2580

agaagccgcc caaggacctg ggctacatct acttctacca gagagtggcc agctaagagc   2640

ctgcctcacc ccttaccaat gagggcaggg gaagaccacc tggcatgagg gagaggggct   2700

gagggatgga cttcagcccc tctgctctgt accctttttc cttttgtccc cggcagcagg   2760

gaagaagctg gaggccgtgg gagaatggct gggcagagca gaggggcagc gatagactct   2820

ggggatggag caggacgggg acgggagggg ccggccacct gtctgtaagg agactttgtt   2880

gcttcccctg cccccggaat ccacagtgct ctgcttctct gtgtcgcccc gcccagcccc   2940

ctggtgtgga gggaggggtc tcgtttgtgc gcgtgggtgt agctttgtgc atcctctccc   3000

agtggagcga tcacctgtgc ctcccctccc cctttgtttg cccctgtgtg gttggtcaag   3060

gagggatgtg agggaaatag ggaccccccg acttgccctc ctgcctcagt ctttccccca   3120

ccctgtctct tccttgtcct tctctggaaa atgccaaaat acacgatgtg aataaaagta   3180

caacggctaa aaaaaaaaaa aaaaaaaaaa aaaa                               3214


<210>  19
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  20
<211>  1852
<212>  DNA
<213>  Homo sapiens

<400>  20
accgccgaga ccgcgtccgc cccgcgagca cagagcctcg cctttgccga tccgccgccc     60

gtccacaccc gccgccagct caccatggat gatgatatcg ccgcgctcgt cgtcgacaac    120

ggctccggca tgtgcaaggc cggcttcgcg ggcgacgatg ccccccgggc cgtcttcccc    180

tccatcgtgg ggcgccccag gcaccagggc gtgatggtgg gcatgggtca gaaggattcc    240

tatgtgggcg acgaggccca gagcaagaga ggcatcctca ccctgaagta ccccatcgag    300

cacggcatcg tcaccaactg ggacgacatg gagaaaatct ggcaccacac cttctacaat    360

gagctgcgtg tggctcccga ggagcacccc gtgctgctga ccgaggcccc cctgaacccc    420

aaggccaacc gcgagaagat gacccagatc atgtttgaga ccttcaacac cccagccatg    480

tacgttgcta tccaggctgt gctatccctg tacgcctctg gccgtaccac tggcatcgtg    540

atggactccg gtgacggggt cacccacact gtgcccatct acgaggggta tgccctcccc    600

catgccatcc tgcgtctgga cctggctggc cgggacctga ctgactacct catgaagatc    660

ctcaccgagc gcggctacag cttcaccacc acggccgagc gggaaatcgt gcgtgacatt    720

aaggagaagc tgtgctacgt cgccctggac ttcgagcaag agatggccac ggctgcttcc    780

agctcctccc tggagaagag ctacgagctg cctgacggcc aggtcatcac cattggcaat    840

gagcggttcc gctgccctga ggcactcttc cagccttcct tcctgggcat ggagtcctgt    900

ggcatccacg aaactacctt caactccatc atgaagtgtg acgtggacat ccgcaaagac    960

ctgtacgcca acacagtgct gtctggcggc accaccatgt accctggcat tgccgacagg   1020

atgcagaagg agatcactgc cctggcaccc agcacaatga agatcaagat cattgctcct   1080

cctgagcgca agtactccgt gtggatcggc ggctccatcc tggcctcgct gtccaccttc   1140

cagcagatgt ggatcagcaa gcaggagtat gacgagtccg gcccctccat cgtccaccgc   1200

aaatgcttct aggcggacta tgacttagtt gcgttacacc ctttcttgac aaaacctaac   1260

ttgcgcagaa aacaagatga gattggcatg gctttatttg ttttttttgt tttgttttgg   1320

tttttttttt ttttttggct tgactcagga tttaaaaact ggaacggtga aggtgacagc   1380

agtcggttgg agcgagcatc ccccaaagtt cacaatgtgg ccgaggactt tgattgcaca   1440

ttgttgtttt tttaatagtc attccaaata tgagatgcgt tgttacagga agtcccttgc   1500

catcctaaaa gccaccccac ttctctctaa ggagaatggc ccagtcctct cccaagtcca   1560

cacaggggag gtgatagcat tgctttcgtg taaattatgt aatgcaaaat ttttttaatc   1620

ttcgccttaa tactttttta ttttgtttta ttttgaatga tgagccttcg tgccccccct   1680

tccccctttt ttgtccccca acttgagatg tatgaaggct tttggtctcc ctgggagtgg   1740

gtggaggcag ccagggctta cctgtacact gacttgagac cagttgaata aaagtgcaca   1800

ccttaaaaat gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa           1852


<210>  21
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Glu Asp Arg Leu His Met Asp Asn Gly Leu Val Pro Gln Lys Ile 
1               5                   10                  15      


Val Ser Val His Leu Gln Asp Ser Thr Leu Lys Glu Val Lys Asp Gln 
            20                  25                  30          


Val Ser Asn Lys Gln Ala Gln Ile Leu Glu Pro Lys Pro Glu Pro Ser 
        35                  40                  45              


Leu Glu Ile Lys Pro Glu Gln Asp Gly Met Glu His Val Gly Arg Asp 
    50                  55                  60                  


Asp Pro Lys Ala Leu Gly Glu Glu Pro Lys Gln Arg Arg Gly Ser Ala 
65                  70                  75                  80  


Ser Gly Ser Glu Pro Ala Gly Asp Ser Asp Arg Gly Gly Gly Pro Val 
                85                  90                  95      


Glu His Tyr His Leu His Leu Ser Ser Cys His Glu Cys Leu Glu Leu 
            100                 105                 110         


Glu Asn Ser Thr Ile Glu Ser Val Lys Phe Ala Ser Ala Glu Asn Ile 
        115                 120                 125             


Pro Asp Leu Pro Tyr Asp Tyr Ser Ser Ser Leu Glu Ser Val Ala Asp 
    130                 135                 140                 


Glu Thr Ser Pro Glu Arg Glu Gly Arg Arg Val Asn Leu Thr Gly Lys 
145                 150                 155                 160 


Ala Pro Asn Ile Leu Leu Tyr Val Gly Ser Asp Ser Gln Glu Ala Leu 
                165                 170                 175     


Gly Arg Phe His Glu Val Arg Ser Val Leu Ala Asp Cys Val Asp Ile 
            180                 185                 190         


Asp Ser Tyr Ile Leu Tyr His Leu Leu Glu Asp Ser Ala Leu Arg Asp 
        195                 200                 205             


Pro Trp Thr Asp Asn Cys Leu Leu Leu Val Ile Ala Thr Arg Glu Ser 
    210                 215                 220                 


Ile Pro Glu Asp Leu Tyr Gln Lys Phe Met Ala Tyr Leu Ser Gln Gly 
225                 230                 235                 240 


Gly Lys Val Leu Gly Leu Ser Ser Ser Phe Thr Phe Gly Gly Phe Gln 
                245                 250                 255     


Val Thr Ser Lys Gly Ala Leu His Lys Thr Val Gln Asn Leu Val Phe 
            260                 265                 270         


Ser Lys Ala Asp Gln Ser Glu Val Lys Leu Ser Val Leu Ser Ser Gly 
        275                 280                 285             


Cys Arg Tyr Gln Glu Gly Pro Val Arg Leu Ser Pro Gly Arg Leu Gln 
    290                 295                 300                 


Gly His Leu Glu Asn Glu Asp Lys Asp Arg Met Ile Val His Val Pro 
305                 310                 315                 320 


Phe Gly Thr Arg Gly Gly Glu Ala Val Leu Cys Gln Val His Leu Glu 
                325                 330                 335     


Leu Pro Pro Ser Ser Asn Ile Val Gln Thr Pro Glu Asp Phe Asn Leu 
            340                 345                 350         


Leu Lys Ser Ser Asn Phe Arg Arg Tyr Glu Val Leu Arg Glu Ile Leu 
        355                 360                 365             


Thr Thr Leu Gly Leu Ser Cys Asp Met Lys Gln Val Pro Ala Leu Thr 
    370                 375                 380                 


Pro Leu Tyr Leu Leu Ser Ala Ala Glu Glu Ile Arg Asp Pro Leu Met 
385                 390                 395                 400 


Gln Trp Leu Gly Lys His Val Asp Ser Glu Gly Glu Ile Lys Ser Gly 
                405                 410                 415     


Gln Leu Ser Leu Arg Phe Val Ser Ser Tyr Val Ser Glu Val Glu Ile 
            420                 425                 430         


Thr Pro Ser Cys Ile Pro Val Val Thr Asn Met Glu Ala Phe Ser Ser 
        435                 440                 445             


Glu His Phe Asn Leu Glu Ile Tyr Arg Gln Asn Leu Gln Thr Lys Gln 
    450                 455                 460                 


Leu Gly Lys Val Ile Leu Phe Ala Glu Val Thr Pro Thr Thr Met Arg 
465                 470                 475                 480 


Leu Leu Asp Gly Leu Met Phe Gln Thr Pro Gln Glu Met Gly Leu Ile 
                485                 490                 495     


Val Ile Ala Ala Arg Gln Thr Glu Gly Lys Gly Arg Gly Gly Asn Val 
            500                 505                 510         


Trp Leu Ser Pro Val Gly Cys Ala Leu Ser Thr Leu Leu Ile Ser Ile 
        515                 520                 525             


Pro Leu Arg Ser Gln Leu Gly Gln Arg Ile Pro Phe Val Gln His Leu 
    530                 535                 540                 


Met Ser Val Ala Val Val Glu Ala Val Arg Ser Ile Pro Glu Tyr Gln 
545                 550                 555                 560 


Asp Ile Asn Leu Arg Val Lys Trp Pro Asn Asp Ile Tyr Tyr Ser Asp 
                565                 570                 575     


Leu Met Lys Ile Gly Gly Val Leu Val Asn Ser Thr Leu Met Gly Glu 
            580                 585                 590         


Thr Phe Tyr Ile Leu Ile Gly Cys Gly Phe Asn Val Thr Asn Ser Asn 
        595                 600                 605             


Pro Thr Ile Cys Ile Asn Asp Leu Ile Thr Glu Tyr Asn Lys Gln His 
    610                 615                 620                 


Lys Ala Glu Leu Lys Pro Leu Arg Ala Asp Tyr Leu Ile Ala Arg Val 
625                 630                 635                 640 


Val Thr Val Leu Glu Lys Leu Ile Lys Glu Phe Gln Asp Lys Gly Pro 
                645                 650                 655     


Asn Ser Val Leu Pro Leu Tyr Tyr Arg Tyr Trp Val His Ser Gly Gln 
            660                 665                 670         


Gln Val His Leu Gly Ser Ala Glu Gly Pro Lys Val Ser Ile Val Gly 
        675                 680                 685             


Leu Asp Asp Ser Gly Phe Leu Gln Val His Gln Glu Gly Gly Glu Val 
    690                 695                 700                 


Val Thr Val His Pro Asp Gly Asn Ser Phe Asp Met Leu Arg Asn Leu 
705                 710                 715                 720 


Ile Leu Pro Lys Arg Arg 
                725     


<210>  22
<211>  6010
<212>  DNA
<213>  Homo sapiens

<400>  22
acgagagggc gcagcgcggc gcggcaggga ttcgcgggcg accacccggc gcaggagcgg     60

ccgcgtttcg gcctcagaat ccattgaaga cttgaacaag tgggccctat ttcttgtgtc    120

tccttttata cttgaagcag aacacatagc atttgtgacg gagagcattt gggtacaaag    180

tgagaattta cagagatcat cctcttcaga aacagttcgg tttttgccca ctagggatga    240

tgtggtttct catgaggtta cttgctctaa aggactttat attttggaac cataagagca    300

cccttgtggc ccaggcactt tatggatgat cccttttagt gctcccagta accttccaag    360

attgtcaagt ggtcagactg ttgtttgcca ttagcttgca gacctgggga tccttatcgg    420

ctaattgctg aagcaagtgt ggacaacttc agcaagctgg gggtggcgtt catggaagat    480

agactccaca tggataatgg actggtaccc caaaagattg tgtcggtgca cttgcaggac    540

tccactctga aggaagttaa ggatcaggtc tcaaacaagc aagcccagat cctagagccg    600

aagcctgaac cttctcttga gattaagcct gagcaggacg gtatggagca tgttggcaga    660

gatgacccaa aggctcttgg tgaagaaccc aaacaaagga gaggcagtgc ctctgggagt    720

gagcctgctg gggacagtga caggggaggg ggccccgttg agcattatca cctccatctg    780

tctagttgcc acgagtgtct ggaacttgag aacagcacca ttgagtcagt caagtttgcg    840

tctgccgaga acattccaga ccttccctac gattatagca gcagtttgga gagtgttgct    900

gatgagacct cccccgaaag agaagggagg agagtcaacc tcacgggaaa ggcacccaac    960

atcctcctct atgtgggctc cgactcccag gaagccctcg gccggttcca cgaggtccgg   1020

tctgtgctgg ccgactgtgt ggacattgac agttatattc tctaccacct gctggaggac   1080

agtgctctca gagacccgtg gacggacaac tgtctgctgt tggtcattgc taccagggag   1140

tccattcccg aagacctgta ccagaagttc atggcctatc tttctcaggg agggaaggtg   1200

ttgggcctgt cttcatcctt cacctttggt ggctttcagg tgacaagcaa gggtgcactg   1260

cacaagacag tccagaactt ggttttctcc aaggctgacc agagcgaggt gaagctcagc   1320

gtcttgagca gtggctgcag gtaccaggaa ggccccgtcc ggctcagccc cggcaggctc   1380

cagggccacc tggagaatga ggacaaggac aggatgattg tgcatgtgcc ttttggaact   1440

cgcgggggag aagctgttct ttgccaggtg cacttagaac tacctcccag ctccaacata   1500

gtgcaaactc cagaagattt taacttgctc aagtcaagca attttagaag atacgaagtc   1560

cttagagaga ttctgacaac ccttggcctc agctgtgaca tgaaacaagt tcctgcctta   1620

actcctcttt acttgctgtc agctgcggag gaaatcaggg atcctcttat gcagtggctt   1680

gggaaacatg tggactccga gggagaaata aaatccggcc agctctctct tagatttgtt   1740

tcatcctacg tgtctgaagt agaaataacc ccatcttgta tacctgtggt gaccaacatg   1800

gaggccttct catcagaaca tttcaactta gagatctatc gccaaaatct gcagaccaag   1860

cagttgggga aagtaatttt gtttgccgaa gtgaccccca caacgatgcg tctcctggat   1920

gggctgatgt ttcagacacc gcaggaaatg ggcttaatag tgatcgcggc ccggcagacc   1980

gagggcaaag gacggggagg gaatgtgtgg ctgagccctg tgggatgtgc tctttctact   2040

ctgctcatct ccattccact gagatcccag ctgggacaga ggatcccgtt tgtccagcat   2100

ctgatgtccg tggctgtcgt ggaagcagtg aggtccattc ccgagtatca ggatatcaac   2160

ttacgagtga agtggcccaa cgatatttat tacagtgacc tcatgaagat cggcggagtt   2220

ctggttaact caacactcat gggagaaaca ttttatatac ttattggctg tggatttaat   2280

gtgactaaca gtaaccctac catctgcatc aacgacctca tcacagaata caataaacaa   2340

cacaaggcag aactgaagcc cttaagagcc gattatctca tcgccagagt cgtgactgtg   2400

ctggagaaac tgatcaaaga gtttcaggac aaagggccca acagcgtcct tcccctttat   2460

taccgatact gggtccacag tggtcagcaa gtccatctgg gcagcgcaga gggaccaaag   2520

gtgtccatcg ttggcctgga cgattctggc ttcctccagg ttcaccagga gggcggcgag   2580

gttgtgactg tgcacccgga cggcaactcc ttcgacatgc tgagaaacct catcctcccc   2640

aaacggcggt aatgccgggc gtccccgaga cgcggctgcc tgtccgtgcc catgcatctg   2700

gaaatctaat ttagagttgt aggtgaattt tcttttcctc caattcattt gttaagtctt   2760

tgttcttttt ctgtgtttct gtttgttttt aggtttgttt tgttgtcgtt ttctttggtg   2820

tttgaagagg ctctgggata gatggttaag aagtagaaaa tttagtttag ggaaagccct   2880

cccacaggtg ggaaattgct ctcccctctg tggcttggac ttacgtttat tgtcaagggg   2940

agtttttaca tggaaatgac aatgggaaaa ttcagatatt ttcttagtag tgcagacctt   3000

tacccctagt ctatgaaaaa acaaaccaaa atatgctctt gcgcccaggc cagtggtgag   3060

ttagaggtat gctatcactg tttgtaagca tctggggagg tactgaactg taagaacatg   3120

cttggacact tagtcattgt tctgtgtttt tattaatgaa gaaaagggaa gacagacttc   3180

caagagttac tgtccacccg gtggtgtggc cccatagcga agtctaaatg cctgtagaga   3240

tagagctagc tggtgtggtt gcagtgacct tgtagaggaa atcagttcat tactttgaca   3300

tcattcagtg agctctcctt tcctaaggaa gtttaaatgt ccttagttag ggactgactt   3360

tcttaagtaa gtttaaattt actacatatt gtgaagagac aggatcaagt tcagaatcct   3420

taaatgtctg attaggcatc acttggatga ggaggtgggc gatttggctc tgacagctgg   3480

agatgaaggc acactcatac cacatacaag ggaggatttg gagcttttaa gccagtttca   3540

gatttactct gaaatgtgga gcattcctgc aagactgtgc agctcacgga atatagaaga   3600

catggcattt tactcagaag tcataagttt ttgcccccct catttacctc gtattaccaa   3660

gaaagaaaat gttatcgata ctaaacacca tcagttcaga gggaggatgt gtgtgtgtgc   3720

ccgcatatgt gtgtgcgtgc gtgtgtgcgc acatagcttt aaaagaagac attcaaaatt   3780

tgatgtgcta caagcctcat gaaagaacaa aagaaatgaa gccttttgat atgcattcgc   3840

tattcccaga tgtacgccat gccttttcca tgtccctcct atctctgttg aacttatgaa   3900

tcatactcat tacttttcag ctttttaaaa ggccaatttt tgtccagttt tctctcttcc   3960

agtcccagct gaaattagtg gaaagaaagt ttgatggagc tttcagcttt gaacaaaatc   4020

ccttcattgt aaactagcac catctttatc caggtcttac ccagtcaggc taattccaga   4080

aacttgtggt ttttagtata gtctgtctac ctttagccag gcacaggaca gccctatgaa   4140

aaaataccca atatatattt tttggaaatg aaacattaaa agaacttaaa aagtaatttt   4200

tggaaatgag gcttcaatta gaattatttt tctcaaaaaa caaacaaaca aaaaacacaa   4260

aaaaaaccac tcttctccaa atgcccaagc cttctttcaa aattagttag aaacttaagt   4320

aaaatacaag tccacaccat ccccaaatta caaaatggac ttacccttga gagggcatct   4380

gcagaatatc atcagggaca aagatctcga ggctaacgat gtaggtttca tttctcagac   4440

tttgtaatat aaggcaagcc ctctctcaga gctgccatca tcactttttg aatttctttg   4500

ggggttattt aatgaaaaac atgctatgtt ttgttttaag ctgaagtcct attctggaca   4560

ctctgctttg ggaaaaaatg ttatcattta atttcctttc tgcaaattaa aactaatgaa   4620

gtgtggcctt gtcaaaggct atggagatgt tccgggcata ctgctgtgct ctgtgctttc   4680

cagcaggcgc tcctccctca cgcaggagac tcagttgtcc tgagagagat gaagcagcct   4740

tgaagcagat gctgcgtttt ccataaacct gattttgcct cacatgaacc aaagactctc   4800

aaaactccgc ttctatagaa ttagctgaat aaaggcattt tactgatagc tgttcgtgtt   4860

agcgaaacct gtctacctgc tatagcacac tctccgattt gggccattta tgcaccccgc   4920

aacctgggat ctcaaggagc tttaaagtct taatgggaac ttggcatttt cctgatgatc   4980

tttaaaatgt ggtcactaaa ctcaggattg gcgtgtgctt ttagaacact ggagtagccc   5040

ttgttttaga ggctgtgcat tgagtatcga ccgtattttg taaaaggcaa gatatcctcc   5100

cttccaggct ggtaacgggt ttcaagggga ctcttgagga agtgccccct aaaatagaac   5160

acagcaataa ctgggcttcc tgtccccacc cccaccccag cagtgctctc tggcactggg   5220

aactctgcta gggagtggtg gaagtaggaa ggatttgtgt gcaaaggaaa atcgtggttg   5280

agtttcactg cagcaggctg acgttgcctg atgtgagagc aagtggccga ctggggtgcg   5340

ggtgcacagg tcgggggagc acaggccaca gagcgcagcc tctgggggtc ccccaaggca   5400

cagcatatac agcatggtcg ccccttgccc tggagtctgg gaacaaagag aggagccagc   5460

ctccccgcac tgcttcagat ggaaaaggga ggcagggtgg gcttccgttc tccagatctg   5520

tttgctctta acaggcagaa catgggagaa tccttattcc tggttaatca ctatgcatat   5580

ttgaaataaa agaaagcgta agcctctgca attttaactt ctcaaaggat gtctctgaaa   5640

agaatcactt taaaccaatg cctataaaaa gcaagtctac caaaataaac taagactttc   5700

tatgtggttt gggctccctc ttatttttac aagtttcatt tttaaaagta ggcaactact   5760

ttgggttaca gtatttttat tcatatttaa acatttttac aaaataaata aagtgtttta   5820

catagtaagg aatatgtacg tatttccaag tattaagaag ccaagtgttt ttttttttga   5880

cgtattattg acaaatgtat tcagcgccat acacaagaga aatattatta ctccaaagaa   5940

cgaaagttaa caaaactcca aagcaaaaac ccttttaatg gaggtgagaa ataaatttaa   6000

tgtaacaaca                                                          6010


<210>  23
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ile Cys Trp Arg His Pro Ser Ala Pro Cys Gly Arg Gly Glu Trp 
1               5                   10                  15      


Gln Val Pro Arg Ser Gln Leu Pro Leu Ala Arg Val Glu Phe Pro Val 
            20                  25                  30          


Ala Leu Gly Leu Gly Val Ala Val Gly Ala Glu Ala Ala Ala Ile Met 
        35                  40                  45              


Val Asn Leu Leu Gln Ile Val Arg Asp His Trp Val His Val Leu Val 
    50                  55                  60                  


Pro Met Gly Phe Val Ile Gly Cys Tyr Leu Asp Arg Lys Ser Asp Glu 
65                  70                  75                  80  


Arg Leu Thr Ala Phe Arg Asn Lys Ser Met Leu Phe Lys Arg Glu Leu 
                85                  90                  95      


Gln Pro Ser Glu Glu Val Thr Trp Lys 
            100                 105 


<210>  24
<211>  433
<212>  DNA
<213>  Homo sapiens

<400>  24
agaggagtca accctgagga ggaaaaagta gtatgatttg ctggcgtcac ccctctgctc     60

cgtgcgggcg cggcgaatgg caggtcccga ggtcgcagct tccactggcg cgggttgagt    120

tccctgttgc ccttggtctc ggggtcgctg taggcgctga ggctgcagct atcatggtga    180

acttacttca gattgtgcgg gaccactggg ttcatgttct tgtccctatg ggatttgtca    240

ttggatgtta tttagacaga aagagtgatg aacggctaac tgccttccgg aacaagagta    300

tgttatttaa aagggaattg caacccagtg aagaagttac ctggaagtaa agactggcta    360

gattatcgaa tgttcacatt ttaaagttct gagagaaata aaaacatgaa gaatctgaaa    420

aaaaaaaaaa aaa                                                       433


<210>  25
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser Glu Tyr 
            20                  25                  30          


Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile Gly Gly 
        35                  40                  45              


Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Val 
65                  70                  75                  80  


Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                85                  90                  95      


Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe Leu Leu 
            100                 105                 110         


Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile Glu Lys 
        115                 120                 125             


Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys 
    130                 135                 140                 


Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Lys Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                165                 170                 175     


Leu Glu Pro Pro Glu Pro Lys Lys Ser Arg Arg Cys Val Leu Leu 
            180                 185                 190     


<210>  26
<211>  2182
<212>  DNA
<213>  Homo sapiens

<400>  26
acttccgcgg gcacccaact gtgcgtctcc tgcgcgctga cgtcaggtgc gtgcccctgt     60

ccggcagccg aggagacccc gcgcagtgct gccaacgccc cggtggagaa gctgaggtca    120

tcatcagatt tgaaatattt aaagtggata caaaactatt tcagcaatgc agacaattaa    180

gtgtgttgtt gtgggcgatg gtgctgttgg taaaacatgt ctcctgatat cctacacaac    240

aaacaaattt ccatcggaat atgtaccgac tgtttttgac aactatgcag tcacagttat    300

gattggtgga gaaccatata ctcttggact ttttgatact gcagggcaag aggattatga    360

cagattacga ccgctgagtt atccacaaac agatgtattt ctagtctgtt tttcagtggt    420

ctctccatct tcatttgaaa acgtgaaaga aaagtgggtg cctgagataa ctcaccactg    480

tccaaagact cctttcttgc ttgttgggac tcaaattgat ctcagagatg acccctctac    540

tattgagaaa cttgccaaga acaaacagaa gcctatcact ccagagactg ctgaaaagct    600

ggcccgtgac ctgaaggctg tcaagtatgt ggagtgttct gcacttacac agaaaggcct    660

aaagaatgta tttgacgaag caatattggc tgccctggag cctccagaac cgaagaagag    720

ccgcaggtgt gtgctgctat gaacatctct ccagagccct ttctgcacag ctggtgtcgg    780

catcatacta aaagcaatgt ttaaatcaaa ctaaagatta aaaattaaaa ttcgtttttg    840

caataatgac aaatgccctg cacctaccca catgcactcg tgtgagacaa ggcccatagg    900

tatggccccc cccttccccc tcccagtact agttaatttt gagtaattgt attgtcagaa    960

aagtgattag tactattttt ttttgttgtt tcaaaaaaaa aatttttgtg tgtgtgtgtt   1020

tttttttttt ttttttttgt tgtttaaaag caaggcatgc ttgtggatga ctctgtaaca   1080

gactaattgg aattgttgaa gctgctccct ggttccactc tggagagtaa tctgggacat   1140

cttagtgttt tgttttgttt ttttccctcc tctttttttt gggggggagt gtgtgtgggg   1200

tttgtttttt agtcttgttt ttttaattca ttaaccagtg gttagccctt aaggggagga   1260

ggacggattg attccacatt ccacttccta gatctagttt agaaaacatg ttccccatct   1320

ggtgctctta ggaaggagta tagtaaatgc ctcatttaat aacatactcc tttttgaaag   1380

ttgccttttc tctccaccct tgagtagatc cagtatttga tgaaactcat gaaagtgggt   1440

ggagcccatc ttgcccctcc tcttttctag gacgcactat atgtgactgt gactttcaag   1500

gacatttgtt tgccatttgc tgattttttt gggaagttaa tttctaactt ctttcactga   1560

taaatgaaga aaagtattgc acctttgaaa tgcaccaaat gaattgagtt tgtaattaaa   1620

aaaatttttt tccctttcag tcattgtctt atatgcttag catagatttg cagctcagta   1680

gtatatggtg ttcctagaat gcagctgaag acctgttatg tagaggaaat acgaggggtg   1740

gtgctagaag acagacatct gtggaatgat tcacatcctc tcaagttagg aggatggagg   1800

cctgcttcat taagaagctg ggggtagggt gggggtgggg agaacactta acaacatggg   1860

gaccagtcag gggaatcccc ttatttctgt tttgcatatg aggaacccta gagcagccag   1920

gtgaggctct ctagtttaat aaaaatcatg gaaagactct taatgcagac tcttcttaag   1980

tgttaatagg gattttttca gcttattttg gttgcagttt ccaattttta aaaatgttga   2040

ggtaatcttt cccaccttcc caaacctaat tcttgtagat gcattagtgt tgaaccaatg   2100

ctttctcatg tctcaattct ttgtatatgc attcttttca gatgtattaa acaaacaaaa   2160

acccttcaaa aaaaaaaaaa aa                                            2182


<210>  27
<211>  847
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ser Gln Arg Gln Gly Lys Glu Ala Tyr Pro Thr Pro Thr Lys Asp 
1               5                   10                  15      


Leu His Gln Pro Ser Leu Ser Pro Ala Ser Pro His Ser Gln Gly Phe 
            20                  25                  30          


Glu Arg Gly Lys Glu Asp Ile Ser Gln Asn Lys Asp Glu Ser Ser Leu 
        35                  40                  45              


Ser Met Ser Lys Ser Lys Ser Glu Ser Lys Leu Tyr Asn Gly Ser Glu 
    50                  55                  60                  


Lys Asp Ser Ser Thr Ser Ser Lys Leu Thr Lys Lys Glu Ser Leu Lys 
65                  70                  75                  80  


Val Gln Lys Lys Asn Tyr Arg Glu Glu Lys Lys Arg Ala Thr Lys Glu 
                85                  90                  95      


Leu Leu Ser Thr Ile Thr Asp Pro Ser Val Ile Val Met Ala Asp Trp 
            100                 105                 110         


Leu Lys Ile Arg Gly Thr Leu Lys Ser Trp Thr Lys Leu Trp Cys Val 
        115                 120                 125             


Leu Lys Pro Gly Val Leu Leu Ile Tyr Lys Thr Gln Lys Asn Gly Gln 
    130                 135                 140                 


Trp Val Gly Thr Val Leu Leu Asn Ala Cys Glu Ile Ile Glu Arg Pro 
145                 150                 155                 160 


Ser Lys Lys Asp Gly Phe Cys Phe Lys Leu Phe His Pro Leu Glu Gln 
                165                 170                 175     


Ser Ile Trp Ala Val Lys Gly Pro Lys Gly Glu Ala Val Gly Ser Ile 
            180                 185                 190         


Thr Gln Pro Leu Pro Ser Ser Tyr Leu Ile Ile Arg Ala Thr Ser Glu 
        195                 200                 205             


Ser Asp Gly Arg Cys Trp Met Asp Ala Leu Glu Leu Ala Leu Lys Cys 
    210                 215                 220                 


Ser Ser Leu Leu Lys Arg Thr Met Ile Arg Glu Gly Lys Glu His Asp 
225                 230                 235                 240 


Leu Ser Val Ser Ser Asp Ser Thr His Val Thr Phe Tyr Gly Leu Leu 
                245                 250                 255     


Arg Ala Asn Asn Leu His Ser Gly Asp Asn Phe Gln Leu Asn Asp Ser 
            260                 265                 270         


Glu Ile Glu Arg Gln His Phe Lys Asp Gln Asp Met Tyr Ser Asp Lys 
        275                 280                 285             


Ser Asp Lys Glu Asn Asp Gln Glu His Asp Glu Ser Asp Asn Glu Val 
    290                 295                 300                 


Met Gly Lys Ser Glu Glu Ser Asp Thr Asp Thr Ser Glu Arg Gln Asp 
305                 310                 315                 320 


Asp Ser Tyr Ile Glu Pro Glu Pro Val Glu Pro Leu Lys Glu Thr Thr 
                325                 330                 335     


Tyr Thr Glu Gln Ser His Glu Glu Leu Gly Glu Ala Gly Glu Ala Ser 
            340                 345                 350         


Gln Thr Glu Thr Val Ser Glu Glu Asn Lys Ser Leu Ile Trp Thr Leu 
        355                 360                 365             


Leu Lys Gln Val Arg Pro Gly Met Asp Leu Ser Lys Val Val Leu Pro 
    370                 375                 380                 


Thr Phe Ile Leu Glu Pro Arg Ser Phe Leu Asp Lys Leu Ser Asp Tyr 
385                 390                 395                 400 


Tyr Tyr His Ala Asp Phe Leu Ser Glu Ala Ala Leu Glu Glu Asn Pro 
                405                 410                 415     


Tyr Phe Arg Leu Lys Lys Val Val Lys Trp Tyr Leu Ser Gly Phe Tyr 
            420                 425                 430         


Lys Lys Pro Lys Gly Leu Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu 
        435                 440                 445             


Thr Phe Arg Cys Leu Trp Ile His Pro Arg Thr Asn Ser Lys Thr Phe 
    450                 455                 460                 


Tyr Ile Ala Glu Gln Val Ser His His Pro Pro Ile Ser Ala Phe Tyr 
465                 470                 475                 480 


Val Ser Asn Arg Lys Asp Gly Phe Cys Leu Ser Gly Ser Ile Leu Ala 
                485                 490                 495     


Lys Ser Lys Phe Tyr Gly Asn Ser Leu Ser Ala Ile Leu Glu Gly Glu 
            500                 505                 510         


Ala Arg Leu Thr Phe Leu Asn Arg Gly Glu Asp Tyr Val Met Thr Met 
        515                 520                 525             


Pro Tyr Ala His Cys Lys Gly Ile Leu Tyr Gly Thr Met Thr Leu Glu 
    530                 535                 540                 


Leu Gly Gly Thr Val Asn Ile Thr Cys Gln Lys Thr Gly Tyr Ser Ala 
545                 550                 555                 560 


Ile Leu Glu Phe Lys Leu Lys Pro Phe Leu Gly Ser Ser Asp Cys Val 
                565                 570                 575     


Asn Gln Ile Ser Gly Lys Leu Lys Leu Gly Lys Glu Val Leu Ala Thr 
            580                 585                 590         


Leu Glu Gly His Trp Asp Ser Glu Val Phe Ile Thr Asp Lys Lys Thr 
        595                 600                 605             


Asp Asn Ser Glu Val Phe Trp Asn Pro Thr Pro Asp Ile Lys Gln Trp 
    610                 615                 620                 


Arg Leu Ile Arg His Thr Val Lys Phe Glu Glu Gln Gly Asp Phe Glu 
625                 630                 635                 640 


Ser Glu Lys Leu Trp Gln Arg Val Thr Arg Ala Ile Asn Ala Lys Asp 
                645                 650                 655     


Gln Thr Glu Ala Thr Gln Glu Lys Tyr Val Leu Glu Glu Ala Gln Arg 
            660                 665                 670         


Gln Ala Ala Arg Asp Arg Lys Thr Lys Asn Glu Glu Trp Ser Cys Lys 
        675                 680                 685             


Leu Phe Glu Leu Asp Pro Leu Thr Gly Glu Trp His Tyr Lys Phe Ala 
    690                 695                 700                 


Asp Thr Arg Pro Trp Asp Pro Leu Asn Asp Met Ile Gln Phe Glu Lys 
705                 710                 715                 720 


Asp Gly Val Ile Gln Thr Lys Val Lys His Arg Thr Pro Met Val Ser 
                725                 730                 735     


Val Pro Lys Met Lys His Lys Pro Thr Arg Gln Gln Lys Lys Val Ala 
            740                 745                 750         


Lys Gly Tyr Ser Ser Pro Glu Pro Asp Ile Gln Asp Ser Ser Gly Ser 
        755                 760                 765             


Glu Ala Gln Ser Val Lys Pro Ser Thr Arg Arg Lys Lys Gly Ile Glu 
    770                 775                 780                 


Leu Gly Asp Ile Gln Ser Ser Ile Glu Ser Ile Lys Gln Thr Gln Glu 
785                 790                 795                 800 


Glu Ile Lys Arg Asn Ile Met Ala Leu Arg Asn His Leu Val Ser Ser 
                805                 810                 815     


Thr Pro Ala Thr Asp Tyr Phe Leu Gln Gln Lys Asp Tyr Phe Ile Ile 
            820                 825                 830         


Phe Leu Leu Ile Leu Leu Gln Val Ile Ile Asn Phe Met Phe Lys 
        835                 840                 845         


<210>  28
<211>  7213
<212>  DNA
<213>  Homo sapiens

<400>  28
cactagaatg tgaaggatct tcgcggttct gggtgcccag aaaggcggcg acgcggcgga     60

tgacaacatt aggccgcgac gcgctcctgg ccaggcggcg gctgtagtgt tagctttgga    120

cgccgcagta gccgctgccg gtagcaagcc gactgaggga aggtgggggt ccgcccgggc    180

tggtggacct cggggccgaa agttcccgcc ccgctcgggg gctgagccgg cagtgcctcc    240

gcggccgctg ggcagcgccc ttcgtccagg ctcgcgcccc agctgccgcc gacgacagcg    300

gccgagagaa gttggggtct gactagacgc ttacggggcc tcggaccccg gcgccgcggc    360

gacctcggag gaaccggctc cttgcgtccc gcctccctgg gagctccgca cgggatttgc    420

agatttacag aatggctgca cattaatgga aagagaagca taaacctatc ttctttcatt    480

atggagggag gtttggcaga tggagaacct gatcgaactt cgcaaacagt gacgaatctc    540

agcttctgac accaggaaag atgagtcagc gccaaggaaa agaagcttat ccaacgccaa    600

ccaaagattt gcatcagcca tctcttagtc cagcaagtcc tcatagccag ggttttgaaa    660

gagggaagga agatatttct caaaataaag atgaatcttc actttctatg tcaaagagca    720

agtctgaatc taaactttat aatggctcag agaaggacag ttcaacttca agcaaactca    780

caaaaaaaga atctcttaag gtacaaaaga aaaattaccg agaagaaaag aaaagagcca    840

caaaggagct gctcagtaca atcacagatc cttctgttat tgttatggct gattggttaa    900

agattcgtgg tactctaaag agctggacca agttatggtg tgtgttgaaa cctggggtgc    960

tactgatcta taaaacccaa aaaaatggtc agtgggtagg aacagttctt ctgaatgcct   1020

gtgaaatcat tgaacgtcca tcaaaaaagg atggcttttg tttcaaactt ttccatcctt   1080

tggagcaatc tatttgggca gtgaagggtc caaaaggtga agcggttgga tccattactc   1140

aacccttacc tagcagttat ttgatcatcc gagctacttc agagtcagat ggaaggtgct   1200

ggatggatgc tttggagttg gctttgaaat gttctagtct tcttaaacgt acaatgatca   1260

gagaaggaaa ggaacatgac ctgagcgttt catcagatag cacacatgtg actttctatg   1320

gcttactacg tgctaacaat ctccacagtg gtgataactt ccagttaaat gatagtgaaa   1380

ttgaacgaca acattttaag gaccaagata tgtattctga taaatctgat aaagaaaatg   1440

atcaagaaca tgatgagtct gataatgagg tgatggggaa aagtgaagaa agtgacacag   1500

atacatcaga aagacaagat gactcatata tcgaacctga gcctgttgag cctttaaagg   1560

agactaccta cactgaacag agccatgaag aacttggaga ggcaggtgag gcttctcaaa   1620

cagaaactgt atctgaagaa aacaaaagcc ttatctggac actattgaaa caagtccgtc   1680

ctggcatgga cctatccaag gtggttctgc ctacatttat tttggaaccc cgttctttcc   1740

tggataaact ttcagattac tactatcatg cagatttcct atctgaggca gctcttgaag   1800

aaaatcctta tttccgtttg aagaaagtag tgaaatggta tttgtcagga ttctataaaa   1860

agccaaaggg actgaagaaa ccttataatc ctatacttgg cgagactttc cgttgtttat   1920

ggattcatcc cagaacaaac agcaaaactt tttatattgc tgaacaggtg tcccatcatc   1980

caccaatatc tgccttttat gttagtaatc gaaaagatgg attttgcctt agcggtagta   2040

tcctggctaa gtctaagttt tatggaaact cattatctgc aatattagag ggagaagcac   2100

ggttaacttt cttgaataga ggtgaagatt atgtaatgac aatgccatac gctcattgta   2160

aaggaattct ttatggtaca atgacactgg agcttggtgg aacagtcaat attacatgtc   2220

aaaaaactgg atacagtgca atacttgaat ttaaactaaa gccattccta gggagtagtg   2280

actgtgttaa tcaaatatca gggaaactta aactgggaaa agaagtccta gctactttgg   2340

aaggtcattg ggatagtgaa gtttttatta ctgataaaaa gactgataat tcagaggttt   2400

tctggaatcc aacacctgac attaagcaat ggagattaat aaggcacact gtaaaatttg   2460

aagaacaggg agattttgaa tcagagaaac tctggcaacg ggtaactcga gccataaatg   2520

ccaaagacca aactgaagct acccaagaga agtatgtttt ggaagaagct caaagacaag   2580

ctgccaggga tcggaaaaca aaaaatgaag agtggtcttg caaattattt gaacttgatc   2640

cactcacagg agaatggcat tacaagtttg cagatacccg accatgggac ccacttaatg   2700

atatgataca gtttgaaaaa gatggtgtta ttcagaccaa agtgaaacat cgtactccaa   2760

tggttagcgt ccccaaaatg aaacataagc caaccaggca acagaagaaa gtagcaaaag   2820

gctattcctc cccagaacct gacattcaag actcctctgg aagtgaagct caatcagtaa   2880

aaccaagtac aagaagaaag aaaggaatag aactgggaga cattcagagt tccatcgaat   2940

ctataaaaca aacacaggaa gaaattaaaa gaaatattat ggctcttcga aatcatttag   3000

tttcaagcac accggccacg gattattttc tgcaacaaaa agactacttc atcattttcc   3060

tcctgatttt gcttcaagtc ataataaact tcatgttcaa gtagaagttc tctaccattg   3120

aatcagtgaa ctagaaagat ctgatttggc ctgggaccag tgttcaagtt ggtttggtct   3180

ttattaaaaa tcacaatatt ccgaaaacaa aaaaacctag gagataaatg tagaggtatt   3240

gacttttcgt atcttttatc ttcacactga aacaagagct atcctatttg attattaaag   3300

tgagctatgt gttaagtgcc aggacatttc tagcttttgt gagaatgtgt ctacatatga   3360

gtataataaa cccacatgta tacacaattg tctcttatgt actcctacct gacagtagtc   3420

tttgtattct atagtatgtt ctgagatata atgttaacat tgttcataac aaaaaatgct   3480

atcaatctta taaatatatg taatctattt tcttcataaa acaggcacaa aagttttatc   3540

agtaaggaat tacagattga gaaatgatgg aataatagac ataattaatt caatacacta   3600

ctgttaaaat catttgcaaa gcactcagct caattatctt cttagaaaga aagaaaaagt   3660

atgaatggtc aaaatgaata catcgagaga gataaatggc aaattgcttt tttaaaagtt   3720

tacataagtt ttttttaacc cctagaattt aatatttgta gatgcaggta aatatatata   3780

cttacgtgta tatcagtata aaaacactgg tgtgcaatta attggattga ttataatacc   3840

accttaagca cttgctgaaa aaagtgtggt caaaattgat tgctgtcctt ttgtcttatt   3900

tttgtttttc ttaagtcagc tggttcataa cataggccaa attctagaga tgtttataga   3960

gcatttgaag tgctgataat ttatgttttt tcattatgaa aacttatttt agctttagac   4020

tccagtgtgt tcagtgaata agtagaatat aaaaaaatat aaccagtatt ttacttcaaa   4080

agccaaaaag aggcaataag aaaagacact ttgtggtggc ctttatgtgt gcattaaaat   4140

tggtttctgt aaaacgtgta ataagttgag tatctacgaa gagtatcaag ttctgaagtt   4200

taattttttt attatcctcc tctcttctta gtaacttctt tctgtggcaa aaccacaatt   4260

ctttaagatt cctattgttc aggctaaggc aaattttttt gtttgtttct tcagtttaat   4320

attttgattt tgtgttttta cgtaaatatt tatattcctt gaaagcaatt tttgccaagg   4380

tagttcagtt taggaatatg ttgttctaaa atatgtctta gaatcctgaa agcatagatt   4440

ttgaaatgtt tttttaatga aaatgaaggt cagagagaat aattgccctg accacatttg   4500

cctttcagta ggaggaggct gtgaaatagt aaaattataa tcgtttatgc catgataaat   4560

acaagattgg taaataaata cattgattgg taaattatga gaatcaaaat gataaaaaga   4620

gcctgctttt ttccctaacc aatatagcta tcttaagtat ccttaggttt ctgtgaagaa   4680

ccatttccca tgttttcttg gcaaaataat gctgtattcc atatgtacat gtgaaatgat   4740

gttttaaatt gataaaagct taaataagat ctacctatac ccagtatttt catgatatta   4800

gaacaaatgg gtttttggtt atattttata tttgtcaata taatttttgt attcacattc   4860

tgttacactc tgcctattca ttgatatatg atattctgta aatattgtac aatttgatct   4920

tttttatggt ttaaattagt taattacata caaattgatt ggcttatcac aaaaatcatt   4980

tcatcagtaa accttgttaa cattttgtac tggtgaccca cctcttagga ctttggtctt   5040

atccacgtgt atgttgtttt catttggtcc aaataatatt ttatttgtat gggtatcttc   5100

taagactaaa taggtagttg tgttctttat ttttaaaatt tctttttaga gcaaatgtta   5160

tgggttctta cccaaagagt caaaaactat ttcttaagaa agagcagagt tattcatgac   5220

tgttctttat acactaaaag catgcatcta atctaatagt cctcttatta tgcttttagt   5280

tgtatgagtc tctttctatg aactgaacac aaaactcagg aattggtggc ttaattttag   5340

atcagtgctt gtactaggct tagttatatg aatctttata acacataatt actaactttg   5400

tagccatata tgtaattgac tttgaatgtt atttacctga aattaatctt ccttcacaca   5460

tggaccgtaa acggttccca gttgtctgag agcctcatga gggtttctag gatttatgac   5520

cttatgacca gtttttttca tttaccaaga ttttattttc ctacatgaaa atttaattga   5580

gtaataatta ttcacatgtg cattttcttt ttagctgtta aatgtactat gccatcatcc   5640

accatttagt aaaatgtagc tggcccagga catgtaaaaa aaaaaaaaaa acaacaacaa   5700

taaatagggc atgtgaaatg ttaagttaca gcaatagata ttttatttgt atttcatgtt   5760

agtacttttt tgttttatat cacttataaa ggtacagtgt actctttgtc acagctcagt   5820

tggtaaccgc attccattga aaagttggcc ttgtaaaata caactctcat ttaatattca   5880

tgcttttgtg cctttaagaa aatatttttt gtcatttttt gtgttacaga actataatgt   5940

gattcaaggt gtttataggc ttgtcataaa agggtcattt ctgtgtgtta ctttcttttt   6000

atatagctat agtatattta aacaataata ctatctttta taggggtttg tctatttacc   6060

tattctttac tcagacattg atgtagactt gtcagattat tctgagtatt gttaacagtg   6120

ccttttcgat ggaatcacac tttttggctg tcaccttgtg ccatatacac acaaaatttt   6180

gtggaaggca gttttaactt tctgaagaat atctgtcaaa atttaagaaa acaaatgtat   6240

aaaattccat tttttccagt gtttagcatt tctagtaagc agtgaggttg tttgacatac   6300

agtgatgatg gcattattga taagccatac atgagactgc agattatatt gaatcatatt   6360

aaatgtacag aaataaaata ttagatttat atcaaatttt ccaatttgaa ccagtgggga   6420

aaatcccaca gaaatcagta agtttacatt tcaatttcta tcttatttga ctaagtggaa   6480

agagattctt taaaatgtat aacctgccat tatgtaattt ggtttcattt tattctacct   6540

gttgtgtgag tttagtatat ttaatttact ttttgttact ctttacatac tgtttatttt   6600

tgttagtttt taattgaaga tggactgttg aaattgtata ggaccagtgt cttattaata   6660

tgattaatat atttagaaga gccacgtgaa acccatgaca aaatgaatgt gaatattctt   6720

tctaaaaatt tagaaaatgt tatctttttg catttattat gtaaaactgt tttacagtat   6780

caaaattttt cacttaaaga aaaaaaatgc catgaaacat ttgaactgat gagccacaga   6840

acttcagttg aaattttttt cactttttag catgctaaat atacatctga gtttaaatgt   6900

tctgtttaat ggccattcat aaattcaagc actaccactg gtcagttttg tgtgatagaa   6960

taaaaatatg ttacctgcag tgtaagtaca gcacactgtc aaattctttt ccttaaggtg   7020

cacagtaaat gtacagatag ttataggcca ctgttttgta atgtagtaca tttctaatct   7080

attattccta acctattata actgtttgca gaaagaaaag aatttttcta ataatctgta   7140

aaattatgct aacttctaca agtaggcttc taaataaaat ttttaaaaag agcaaaaaaa   7200

aaaaaaaaaa aaa                                                      7213


<210>  29
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ser Glu Arg Glu Val Ser Thr Ala Pro Ala Gly Thr Asp Met Pro 
1               5                   10                  15      


Ala Ala Lys Lys Gln Lys Leu Ser Ser Asp Glu Asn Ser Asn Pro Asp 
            20                  25                  30          


Leu Ser Gly Asp Glu Asn Asp Asp Ala Val Ser Ile Glu Ser Gly Thr 
        35                  40                  45              


Asn Thr Glu Arg Pro Asp Thr Pro Thr Asn Thr Pro Asn Ala Pro Gly 
    50                  55                  60                  


Arg Lys Ser Trp Gly Lys Gly Lys Trp Lys Ser Lys Lys Cys Lys Tyr 
65                  70                  75                  80  


Ser Phe Lys Cys Val Asn Ser Leu Lys Glu Asp His Asn Gln Pro Leu 
                85                  90                  95      


Phe Gly Val Gln Phe Asn Trp His Ser Lys Glu Gly Asp Pro Leu Val 
            100                 105                 110         


Phe Ala Thr Val Gly Ser Asn Arg Val Thr Leu Tyr Glu Cys His Ser 
        115                 120                 125             


Gln Gly Glu Ile Arg Leu Leu Gln Ser Tyr Val Asp Ala Asp Ala Asp 
    130                 135                 140                 


Glu Asn Phe Tyr Thr Cys Ala Trp Thr Tyr Asp Ser Asn Thr Ser His 
145                 150                 155                 160 


Pro Leu Leu Ala Val Ala Gly Ser Arg Gly Ile Ile Arg Ile Ile Asn 
                165                 170                 175     


Pro Ile Thr Met Gln Cys Ile Lys His Tyr Val Gly His Gly Asn Ala 
            180                 185                 190         


Ile Asn Glu Leu Lys Phe His Pro Arg Asp Pro Asn Leu Leu Leu Ser 
        195                 200                 205             


Val Ser Lys Asp His Ala Leu Arg Leu Trp Asn Ile Gln Thr Asp Thr 
    210                 215                 220                 


Leu Val Ala Ile Phe Gly Gly Val Glu Gly His Arg Asp Glu Val Leu 
225                 230                 235                 240 


Ser Ala Asp Tyr Asp Leu Leu Gly Glu Lys Ile Met Ser Cys Gly Met 
                245                 250                 255     


Asp His Ser Leu Lys Leu Trp Arg Ile Asn Ser Lys Arg Met Met Asn 
            260                 265                 270         


Ala Ile Lys Glu Ser Tyr Asp Tyr Asn Pro Asn Lys Thr Asn Arg Pro 
        275                 280                 285             


Phe Ile Ser Gln Lys Ile His Phe Pro Asp Phe Ser Thr Arg Asp Ile 
    290                 295                 300                 


His Arg Asn Tyr Val Asp Cys Val Arg Trp Leu Gly Asp Leu Ile Leu 
305                 310                 315                 320 


Ser Lys Ser Cys Glu Asn Ala Ile Val Cys Trp Lys Pro Gly Lys Met 
                325                 330                 335     


Glu Asp Asp Ile Asp Lys Ile Lys Pro Ser Glu Ser Asn Val Thr Ile 
            340                 345                 350         


Leu Gly Arg Phe Asp Tyr Ser Gln Cys Asp Ile Trp Tyr Met Arg Phe 
        355                 360                 365             


Ser Met Asp Phe Trp Gln Lys Met Leu Ala Leu Gly Asn Gln Val Gly 
    370                 375                 380                 


Lys Leu Tyr Val Trp Asp Leu Glu Val Glu Asp Pro His Lys Ala Lys 
385                 390                 395                 400 


<210>  30
<211>  2413
<212>  DNA
<213>  Homo sapiens

<400>  30
ctagcagcgg gtcggagatc gaaggaacgg gccaattgcg gctgaaacgt ctttggaagg     60

aggaaggggg tgagggagca tccctttgag tttcgcctct tctcgaggcg gtggtgggaa    120

gggagacata cttaatactg ccctcttaat ccaacggacc ttacatcgtg tagactgccg    180

ggagggcggc gggaaaaggg caagacggga gttggggaag ggaaggagcc aggaagccgc    240

gcgggagggc gcgcgcgcgc gccccttttt cagcagtgtg gcggggtcgc acgcacgccc    300

gcctcggcgg ctgggcgcga tttgcgacag tggggggggc ggtggaggtg gcggcggcag    360

cggcaacttt gcggcaagct cgggccgggc ttgcttgacg gcggtgtggc ggaggccccg    420

ccccaggcgg caggaacctg gagggaggcg gaggaatatg tccgagaggg aagtgtcgac    480

tgcgccggcg ggaacagaca tgcctgcggc caagaagcag aagctgagca gtgacgagaa    540

cagcaatcca gacctctctg gagacgagaa tgatgacgct gtcagtatag aaagtggtac    600

aaacactgaa cgccctgata cacctacaaa cacgccaaat gcacctggaa ggaaaagttg    660

gggaaaggga aaatggaagt caaagaaatg caaatattct ttcaaatgtg taaatagtct    720

caaggaagat cataaccaac cattgtttgg agttcagttt aactggcaca gtaaagaagg    780

agatccatta gtgtttgcaa ctgtaggaag caacagagtt accttgtatg aatgtcattc    840

acaaggagaa atccggttgt tgcaatctta cgtggatgct gatgctgatg aaaactttta    900

cacttgtgca tggacctatg atagcaatac gagccatcct ctgctggctg tagctggatc    960

tagaggcata attaggataa taaatcctat aacaatgcag tgtataaagc actatgttgg   1020

ccatggaaat gctatcaatg agctgaaatt ccatccaaga gatccaaatc ttctcctgtc   1080

agtaagtaaa gatcatgctt tacgattatg gaatatccag acggacactc tggtggcaat   1140

atttggaggc gtagaagggc acagagatga agttctaagt gctgattatg atcttttggg   1200

tgaaaaaata atgtcctgtg gtatggatca ttctcttaaa ctttggagga tcaattcaaa   1260

gagaatgatg aatgcaatta aggaatctta tgattataat ccaaataaaa ctaacaggcc   1320

atttatttct cagaaaatcc attttcctga tttttctacc agagacatac ataggaatta   1380

tgttgattgt gtgcgatggt taggcgattt gatactttct aagtcttgtg aaaatgccat   1440

tgtgtgctgg aaacctggca agatggaaga tgatatagat aaaattaaac ccagtgaatc   1500

taatgtgact attcttgggc gatttgatta cagccagtgt gacatttggt acatgaggtt   1560

ttctatggat ttctggcaaa agatgcttgc attgggcaat caagttggca aactttatgt   1620

ttgggattta gaagtagaag atcctcataa agccaagtaa gtatttagaa atttctgttc   1680

aaaatttcag gctttttctc cacacttgta tgccaatgta gagaagatca tttatatttg   1740

cagtgccatc cttaagtcat ttttaacatt tactgttttc agagttaaag ttattctttt   1800

ttattccaat aatttttgtt tttcctaagt accttggtga caagtcattt cttgttttta   1860

tacaaattat gtagtgcttg ttgaacttaa aatatatcta aattttataa aatttgagac   1920

tgagctctta gtgaagtata ttctggtttt aagtgctttt cgtatgactt ggaacatctg   1980

cttattttct aatccgctgt tttagggtag acactgacaa cgttatgtgt ggtctttaac   2040

ctgttgtcat gttttttccc tagatgtaca acactgactc atcataaatg tggtgctgct   2100

attcgacaaa ccagttttag cagggatagc agcattctta tagctgtttg tgatgatgcc   2160

agtatttggc gctgggatcg acttcgataa aatacttttg cctaatcaaa attagagtgt   2220

gtttgttgtc tgtgtaaaat agaattaatg tatcttgcta gtaagggcac gtagagcatt   2280

tagagttgtc tttcagcatt caatcaggct gagctgaatg tagtgatgtt tacattgttt   2340

acattctttg tactgtcttc ctgctcagac tctactgctt ttaataaaaa tttatttttg   2400

taaaaaaaaa aaa                                                      2413


<210>  31
<211>  1149
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Pro Ala Pro Glu Gln Ala Ser Leu Val Glu Glu Gly Gln Pro Gln 
1               5                   10                  15      


Thr Arg Gln Glu Ala Ala Ser Thr Gly Pro Gly Met Glu Pro Glu Thr 
            20                  25                  30          


Thr Ala Thr Thr Ile Leu Ala Ser Val Lys Glu Gln Glu Leu Gln Phe 
        35                  40                  45              


Gln Arg Leu Thr Arg Glu Leu Glu Val Glu Arg Gln Ile Val Ala Ser 
    50                  55                  60                  


Gln Leu Glu Arg Cys Arg Leu Gly Ala Glu Ser Pro Ser Ile Ala Ser 
65                  70                  75                  80  


Thr Ser Ser Thr Glu Lys Ser Phe Pro Trp Arg Ser Thr Asp Val Pro 
                85                  90                  95      


Asn Thr Gly Val Ser Lys Pro Arg Val Ser Asp Ala Val Gln Pro Asn 
            100                 105                 110         


Asn Tyr Leu Ile Arg Thr Glu Pro Glu Gln Gly Thr Leu Tyr Ser Pro 
        115                 120                 125             


Glu Gln Thr Ser Leu His Glu Ser Glu Gly Ser Leu Gly Asn Ser Arg 
    130                 135                 140                 


Ser Ser Thr Gln Met Asn Ser Tyr Ser Asp Ser Gly Tyr Gln Glu Ala 
145                 150                 155                 160 


Gly Ser Phe His Asn Ser Gln Asn Val Ser Lys Ala Asp Asn Arg Gln 
                165                 170                 175     


Gln His Ser Phe Ile Gly Ser Thr Asn Asn His Val Val Arg Asn Ser 
            180                 185                 190         


Arg Ala Glu Gly Gln Thr Leu Val Gln Pro Ser Val Ala Asn Arg Ala 
        195                 200                 205             


Met Arg Arg Val Ser Ser Val Pro Ser Arg Ala Gln Ser Pro Ser Tyr 
    210                 215                 220                 


Val Ile Ser Thr Gly Val Ser Pro Ser Arg Gly Ser Leu Arg Thr Ser 
225                 230                 235                 240 


Leu Gly Ser Gly Phe Gly Ser Pro Ser Val Thr Asp Pro Arg Pro Leu 
                245                 250                 255     


Asn Pro Ser Ala Tyr Ser Ser Thr Thr Leu Pro Ala Ala Arg Ala Ala 
            260                 265                 270         


Ser Pro Tyr Ser Gln Arg Pro Ala Ser Pro Thr Ala Ile Arg Arg Ile 
        275                 280                 285             


Gly Ser Val Thr Ser Arg Gln Thr Ser Asn Pro Asn Gly Pro Thr Pro 
    290                 295                 300                 


Gln Tyr Gln Thr Thr Ala Arg Val Gly Ser Pro Leu Thr Leu Thr Asp 
305                 310                 315                 320 


Ala Gln Thr Arg Val Ala Ser Pro Ser Gln Gly Gln Val Gly Ser Ser 
                325                 330                 335     


Ser Pro Lys Arg Ser Gly Met Thr Ala Val Pro Gln His Leu Gly Pro 
            340                 345                 350         


Ser Leu Gln Arg Thr Val His Asp Met Glu Gln Phe Gly Gln Gln Gln 
        355                 360                 365             


Tyr Asp Ile Tyr Glu Arg Met Val Pro Pro Arg Pro Asp Ser Leu Thr 
    370                 375                 380                 


Gly Leu Arg Ser Ser Tyr Ala Ser Gln His Ser Gln Leu Gly Gln Asp 
385                 390                 395                 400 


Leu Arg Ser Ala Val Ser Pro Asp Leu His Ile Thr Pro Ile Tyr Glu 
                405                 410                 415     


Gly Arg Thr Tyr Tyr Ser Pro Val Tyr Arg Ser Pro Asn His Gly Thr 
            420                 425                 430         


Val Glu Leu Gln Gly Ser Gln Thr Ala Leu Tyr Arg Thr Gly Ser Val 
        435                 440                 445             


Gly Ile Gly Asn Leu Gln Arg Thr Ser Ser Gln Arg Ser Thr Leu Thr 
    450                 455                 460                 


Tyr Gln Arg Asn Asn Tyr Ala Leu Asn Thr Thr Ala Thr Tyr Ala Glu 
465                 470                 475                 480 


Pro Tyr Arg Pro Ile Gln Tyr Arg Val Gln Glu Cys Asn Tyr Asn Arg 
                485                 490                 495     


Leu Gln His Ala Val Pro Ala Asp Asp Gly Thr Thr Arg Ser Pro Ser 
            500                 505                 510         


Ile Asp Ser Ile Gln Lys Asp Pro Arg Glu Phe Ala Trp Arg Asp Pro 
        515                 520                 525             


Glu Leu Pro Glu Val Ile His Met Leu Gln His Gln Phe Pro Ser Val 
    530                 535                 540                 


Gln Ala Asn Ala Ala Ala Tyr Leu Gln His Leu Cys Phe Gly Asp Asn 
545                 550                 555                 560 


Lys Val Lys Met Glu Val Cys Arg Leu Gly Gly Ile Lys His Leu Val 
                565                 570                 575     


Asp Leu Leu Asp His Arg Val Leu Glu Val Gln Lys Asn Ala Cys Gly 
            580                 585                 590         


Ala Leu Arg Asn Leu Val Phe Gly Lys Ser Thr Asp Glu Asn Lys Ile 
        595                 600                 605             


Ala Met Lys Asn Val Gly Gly Ile Pro Ala Leu Leu Arg Leu Leu Arg 
    610                 615                 620                 


Lys Ser Ile Asp Ala Glu Val Arg Glu Leu Val Thr Gly Val Leu Trp 
625                 630                 635                 640 


Asn Leu Ser Ser Cys Asp Ala Val Lys Met Thr Ile Ile Arg Asp Ala 
                645                 650                 655     


Leu Ser Thr Leu Thr Asn Thr Val Ile Val Pro His Ser Gly Trp Asn 
            660                 665                 670         


Asn Ser Ser Phe Asp Asp Asp His Lys Ile Lys Phe Gln Thr Ser Leu 
        675                 680                 685             


Val Leu Arg Asn Thr Thr Gly Cys Leu Arg Asn Leu Ser Ser Ala Gly 
    690                 695                 700                 


Glu Glu Ala Arg Lys Gln Met Arg Ser Cys Glu Gly Leu Val Asp Ser 
705                 710                 715                 720 


Leu Leu Tyr Val Ile His Thr Cys Val Asn Thr Ser Asp Tyr Asp Ser 
                725                 730                 735     


Lys Thr Val Glu Asn Cys Val Cys Thr Leu Arg Asn Leu Ser Tyr Arg 
            740                 745                 750         


Leu Glu Leu Glu Val Pro Gln Ala Arg Leu Leu Gly Leu Asn Glu Leu 
        755                 760                 765             


Asp Asp Leu Leu Gly Lys Glu Ser Pro Ser Lys Asp Ser Glu Pro Ser 
    770                 775                 780                 


Cys Trp Gly Lys Lys Lys Lys Lys Lys Lys Arg Thr Pro Gln Glu Asp 
785                 790                 795                 800 


Gln Trp Asp Gly Val Gly Pro Ile Pro Gly Leu Ser Lys Ser Pro Lys 
                805                 810                 815     


Gly Val Glu Met Leu Trp His Pro Ser Val Val Lys Pro Tyr Leu Thr 
            820                 825                 830         


Leu Leu Ala Glu Ser Ser Asn Pro Ala Thr Leu Glu Gly Ser Ala Gly 
        835                 840                 845             


Ser Leu Gln Asn Leu Ser Ala Gly Asn Trp Lys Phe Ala Ala Tyr Ile 
    850                 855                 860                 


Arg Ala Ala Val Arg Lys Glu Lys Gly Leu Pro Ile Leu Val Glu Leu 
865                 870                 875                 880 


Leu Arg Met Asp Asn Asp Arg Val Val Ser Ser Val Ala Thr Ala Leu 
                885                 890                 895     


Arg Asn Met Ala Leu Asp Val Arg Asn Lys Glu Leu Ile Gly Lys Tyr 
            900                 905                 910         


Ala Met Arg Asp Leu Val Asn Arg Leu Pro Gly Gly Asn Gly Pro Ser 
        915                 920                 925             


Val Leu Ser Asp Glu Thr Met Ala Ala Ile Cys Cys Ala Leu His Glu 
    930                 935                 940                 


Val Thr Ser Lys Asn Met Glu Asn Ala Lys Ala Leu Ala Asp Ser Gly 
945                 950                 955                 960 


Gly Ile Glu Lys Leu Val Asn Ile Thr Lys Gly Arg Gly Asp Arg Ser 
                965                 970                 975     


Ser Leu Lys Val Val Lys Ala Ala Ala Gln Val Leu Asn Thr Leu Trp 
            980                 985                 990         


Gln Tyr Arg Asp Leu Arg Ser Ile  Tyr Lys Lys Asp Gly  Trp Asn Gln 
        995                 1000                 1005             


Asn His  Phe Ile Thr Pro Val  Ser Thr Leu Glu Arg  Asp Arg Phe 
    1010                 1015                 1020             


Lys Ser  His Pro Ser Leu Ser  Thr Thr Asn Gln Gln  Met Ser Pro 
    1025                 1030                 1035             


Ile Ile  Gln Ser Gly Ser Ser  Lys Pro Ser Pro Ile  Tyr Ile Ser 
    1040                 1045                 1050             


Ser Tyr  Ser Ser Pro Ala Arg  Glu Gln Asn Arg Arg  Leu Gln His 
    1055                 1060                 1065             


Gln Gln  Leu Tyr Tyr Ser Gln  Asp Asp Ser Asn Arg  Lys Asn Phe 
    1070                 1075                 1080             


Asp Ala  Tyr Arg Leu Tyr Leu  Gln Ser Pro His Ser  Tyr Glu Asp 
    1085                 1090                 1095             


Pro Tyr  Phe Asp Asp Arg Val  His Phe Pro Ala Ser  Thr Asp Tyr 
    1100                 1105                 1110             


Ser Thr  Gln Tyr Gly Leu Lys  Ser Thr Thr Asn Tyr  Val Asp Phe 
    1115                 1120                 1125             


Tyr Ser  Thr Lys Arg Pro Ser  Tyr Arg Ala Glu Gln  Tyr Pro Gly 
    1130                 1135                 1140             


Ser Pro  Asp Ser Trp Val 
    1145                 


<210>  32
<211>  4475
<212>  DNA
<213>  Homo sapiens

<400>  32
tccggggctg agtccgcgtc gacgccggcc gcggaggcgg caccatgggc aaggggtaga     60

ggggcaagtt ggccaccgcc gccgccgggg gtggtgggag agccgctccg ggggcggggg    120

ccggtggggg agggaggggc gggcagccgc gccgccgcgg cactttttta attttttcgg    180

gtgccgcagc ggcgacccct cggcgccgat gtccctgatc cctggagcga cgacggccgc    240

tgcctaagct ggaaagagga atgccagctc ctgagcaggc ctcattggtg gaggaggggc    300

aaccacagac ccgccaggaa gctgcctcca ctggcccagg catggaaccc gagaccacag    360

ccaccactat tctagcatcc gtgaaggagc aggagcttca gtttcagcga ctcacccgag    420

aactggaagt ggaaaggcag attgttgcca gtcagctaga aagatgtagg cttggagcag    480

aatcaccaag catcgccagc accagctcaa ctgagaagtc atttccttgg agatcaacag    540

acgtgccaaa tactggtgta agcaaaccta gagtttctga cgctgtccag cccaacaact    600

atctcatcag gacagagcca gaacaaggaa ccctctattc accagaacag acatctctcc    660

atgaaagtga gggatcattg ggtaactcaa gaagttcaac acaaatgaat tcttattccg    720

acagtggata ccaggaagca gggagtttcc acaacagcca gaacgtgagc aaggcagaca    780

acagacagca gcattcattc ataggatcaa ctaacaacca tgtggtgagg aattcaagag    840

ctgaaggaca aacactggtt cagccatcag tagccaatcg ggccatgaga agagttagtt    900

cagttccatc tagagcacag tctccttctt atgttatcag cacaggcgtg tctccttcaa    960

gggggtctct gagaacttct ctgggtagtg gatttggctc tccgtcagtg accgaccccc   1020

gacctctgaa ccccagtgca tattcctcca ccacattacc tgctgcacgg gcagcctctc   1080

cgtactcaca gagacccgcc tccccaacag ctatacggcg gattgggtca gtcacctccc   1140

ggcagacctc caatcccaac ggaccaaccc ctcaatacca aaccaccgcc agagtggggt   1200

ccccactgac cctgacggat gcacagactc gagtagcttc cccatcccaa ggccaggtgg   1260

ggtcgtcgtc ccccaaacgc tcagggatga ccgccgtacc acagcatctg ggaccttcac   1320

tgcaaaggac tgttcatgac atggagcaat tcggacagca gcagtatgac atttatgaga   1380

ggatggttcc acccaggcca gacagcctga caggcttacg gagttcctat gctagtcagc   1440

atagtcagct tgggcaagac cttcgttctg ccgtgtctcc cgacttgcac attactccta   1500

tatatgaggg gaggacctat tacagcccag tgtaccgcag cccaaaccat ggaactgtgg   1560

agctccaagg atcgcagacg gcgttgtatc gcacaggttc agtaggtatt ggaaatctac   1620

aaaggacatc cagccaacga agtaccctta cataccaaag aaataattat gctctgaaca   1680

caacagctac ctacgcggag ccctacaggc ctatacaata ccgagtgcaa gagtgcaatt   1740

ataacaggct tcagcatgca gtgccggctg atgatggcac cacaagatcc ccatcaatag   1800

acagcattca gaaggacccc agggagtttg cctggcgtga tcctgagttg cctgaggtca   1860

ttcacatgct tcagcaccag ttcccatctg ttcaggcaaa tgcagcggcc tacctgcagc   1920

acctgtgctt tggtgacaac aaagtgaaga tggaggtgtg taggttaggg ggaatcaagc   1980

atctggttga ccttctggac cacagagttt tggaagttca gaagaatgct tgtggtgccc   2040

ttcgaaacct cgtttttggc aagtctacag atgaaaataa aatagcaatg aagaatgttg   2100

gtgggatacc tgccttgttg cgactgttga gaaaatctat tgatgcagaa gtaagggagc   2160

ttgttacagg agttctttgg aatttatcct catgtgatgc tgtaaaaatg acaatcattc   2220

gagatgctct ctcaacctta acaaacactg tgattgttcc acattctgga tggaataact   2280

cttcttttga tgatgatcat aaaattaaat ttcagacttc actagttctg cgtaacacga   2340

caggttgcct aaggaacctc agctccgcgg gggaagaagc tcggaagcaa atgcggtcct   2400

gcgaggggct ggtagactca ctgttgtatg tgatccacac gtgtgtgaac acatccgatt   2460

acgacagcaa gacggtggag aactgcgtgt gcaccctgag gaacctgtcc tatcggctgg   2520

agctggaggt gccccaggcc cggttactgg gactgaacga attggatgac ttactaggaa   2580

aagagtctcc cagcaaagac tctgagccaa gttgctgggg gaagaagaag aaaaagaaaa   2640

agaggactcc gcaagaagat caatgggatg gagttggtcc tatcccagga ctgtcgaagt   2700

cccccaaagg ggttgagatg ctgtggcacc catcggtggt aaaaccatat ctgactcttc   2760

tagcagaaag ttccaaccca gccaccttgg aaggctctgc agggtctctc cagaacctct   2820

ctgctggcaa ctggaagttt gcagcatata tccgggcggc cgtccgaaaa gaaaaggggc   2880

tccccatcct tgtggagctt ctgagaatgg ataacgatag agttgtttct tccgtggcaa   2940

cagccttgag gaatatggca ctagatgttc gcaacaagga gctcataggc aaatacgcca   3000

tgcgagacct ggtcaaccgg ctccccggcg gcaatggccc cagtgtcttg tctgatgaga   3060

ccatggcagc catctgctgt gctctgcacg aggtcaccag caaaaacatg gagaacgcaa   3120

aagccctggc cgactcagga ggcatagaga agctggtgaa cataaccaaa ggcaggggcg   3180

acagatcatc tctgaaagtg gtgaaggcag cagcccaggt cttgaataca ttatggcaat   3240

atcgggacct ccggagcatt tataaaaagg atgggtggaa tcagaaccat tttattacac   3300

ctgtgtcgac attggagcga gaccgattca aatcacatcc ttccttgtct accaccaacc   3360

aacagatgtc acccatcatt cagtcaggct ccagcaaacc ttcaccaatt tacatcagtt   3420

cctattcctc accagcaaga gaacaaaata gacggctaca gcatcaacag ctgtattata   3480

gtcaagatga ctccaacaga aagaactttg atgcatacag attgtatttg cagtctcctc   3540

atagctatga agatccttat tttgatgacc gagttcactt tccagcttct actgattact   3600

caacacagta tggactgaaa tcgaccacaa attatgtaga cttttattcc actaaacgac   3660

cttcttatag agcagaacag tacccagggt ccccagactc atgggtgtag catcaagatg   3720

cccaacagag gaactctttc tttctaacct tgttcagatt gaggtgaaaa gtccatcttg   3780

ctgatttgat gattgaaatg tgaaagtgaa gtggaaggaa tgaatgaagt gtgttttttt   3840

tttctttttt gaggaattat cagggaagtg aggaaatgtt tgggagagga ctttctaagc   3900

tctatttagg tgttagatct aattacttat agattctgta gtctggtgaa ggtgtgggtg   3960

acgtgatgag aggtttgaga aatgggtgaa atgaaatggg ggatatgtag gtcaaatcaa   4020

attaaagatg atttttttaa tgtgaataaa gttatgttct gatagtttgt acagaaaaaa   4080

taaaatggat gcccatgttt tattgctatt actaaatgtc aagattgtat gctattatgt   4140

cttgtaaatt tcttttgttg gtgtaaatat ggaaatgcca cattggttaa gtgccatcat   4200

ttgtaatgca atgtgtcact tgaaaagaga tttgaagaaa ctgacaactt caaaaacaaa   4260

tgagaagccc aaggaactgt gagcaattaa aagcaaaccg cgacaccctt tgtctccacc   4320

acacatagtg tactttggaa gcacaacgtc caggctggta ccgcagcgcc atgcccattc   4380

ctcgcctcgt tcataggaca cttcactgcc attttctatt cacataaaag aaaaataaat   4440

gtggaaattt catccttgga aaaaaaaaaa aaaaa                              4475


<210>  33
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Glu Leu Ser Glu Glu Ala Leu Leu Ser Val Leu Pro Thr Ile 
1               5                   10                  15      


Arg Val Pro Lys Ala Gly Asp Arg Val His Lys Asp Glu Cys Ala Phe 
            20                  25                  30          


Ser Phe Asp Thr Pro Glu Ser Glu Gly Gly Leu Tyr Ile Cys Met Asn 
        35                  40                  45              


Thr Phe Leu Gly Phe Gly Lys Gln Tyr Val Glu Arg His Phe Asn Lys 
    50                  55                  60                  


Thr Gly Gln Arg Val Tyr Leu His Leu Arg Arg Thr Arg Arg Pro Lys 
65                  70                  75                  80  


Glu Glu Asp Pro Ala Thr Gly Thr Gly Asp Pro Pro Arg Lys Lys Pro 
                85                  90                  95      


Thr Arg Leu Ala Ile Gly Val Glu Gly Gly Phe Asp Leu Ser Glu Glu 
            100                 105                 110         


Lys Phe Glu Leu Asp Glu Asp Val Lys Ile Val Ile Leu Pro Asp Tyr 
        115                 120                 125             


Leu Glu Ile Ala Arg Asp Gly Leu Gly Gly Leu Pro Asp Ile Val Arg 
    130                 135                 140                 


Asp Arg Val Thr Ser Ala Val Glu Ala Leu Leu Ser Ala Asp Ser Ala 
145                 150                 155                 160 


Ser Arg Lys Gln Glu Val Gln Ala Trp Asp Gly Glu Val Arg Gln Val 
                165                 170                 175     


Ser Lys His Ala Phe Ser Leu Lys Gln Leu Asp Asn Pro Ala Arg Ile 
            180                 185                 190         


Pro Pro Cys Gly Trp Lys Cys Ser Lys Cys Asp Met Arg Glu Asn Leu 
        195                 200                 205             


Trp Leu Asn Leu Thr Asp Gly Ser Ile Leu Cys Gly Arg Arg Tyr Phe 
    210                 215                 220                 


Asp Gly Ser Gly Gly Asn Asn His Ala Val Glu His Tyr Arg Glu Thr 
225                 230                 235                 240 


Gly Tyr Pro Leu Ala Val Lys Leu Gly Thr Ile Thr Pro Asp Gly Ala 
                245                 250                 255     


Asp Val Tyr Ser Tyr Asp Glu Asp Asp Met Val Leu Asp Pro Ser Leu 
            260                 265                 270         


Ala Glu His Leu Ser His Phe Gly Ile Asp Met Leu Lys Met Gln Lys 
        275                 280                 285             


Thr Asp Lys Thr Met Thr Glu Leu Glu Ile Asp Met Asn Gln Arg Ile 
    290                 295                 300                 


Gly Glu Trp Glu Leu Ile Gln Glu Ser Gly Val Pro Leu Lys Pro Leu 
305                 310                 315                 320 


Phe Gly Pro Gly Tyr Thr Gly Ile Arg Asn Leu Gly Asn Ser Cys Tyr 
                325                 330                 335     


Leu Asn Ser Val Val Gln Val Leu Phe Ser Ile Pro Asp Phe Gln Arg 
            340                 345                 350         


Lys Tyr Val Asp Lys Leu Glu Lys Ile Phe Gln Asn Ala Pro Thr Asp 
        355                 360                 365             


Pro Thr Gln Asp Phe Ser Thr Gln Val Ala Lys Leu Gly His Gly Leu 
    370                 375                 380                 


Leu Ser Gly Glu Tyr Ser Lys Pro Val Pro Glu Ser Gly Asp Gly Glu 
385                 390                 395                 400 


Arg Val Pro Glu Gln Lys Glu Val Gln Asp Gly Ile Ala Pro Arg Met 
                405                 410                 415     


Phe Lys Ala Leu Ile Gly Lys Gly His Pro Glu Phe Ser Thr Asn Arg 
            420                 425                 430         


Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Ile Asn Met Val Glu 
        435                 440                 445             


Arg Asn Cys Arg Ser Ser Glu Asn Pro Asn Glu Val Phe Arg Phe Leu 
    450                 455                 460                 


Val Glu Glu Lys Ile Lys Cys Leu Ala Thr Glu Lys Val Lys Tyr Thr 
465                 470                 475                 480 


Gln Arg Val Asp Tyr Ile Met Gln Leu Pro Val Pro Met Asp Ala Ala 
                485                 490                 495     


Leu Asn Lys Glu Glu Leu Leu Glu Tyr Glu Glu Lys Lys Arg Gln Ala 
            500                 505                 510         


Glu Glu Glu Lys Met Ala Leu Pro Glu Leu Val Arg Ala Gln Val Pro 
        515                 520                 525             


Phe Ser Ser Cys Leu Glu Ala Tyr Gly Ala Pro Glu Gln Val Asp Asp 
    530                 535                 540                 


Phe Trp Ser Thr Ala Leu Gln Ala Lys Ser Val Ala Val Lys Thr Thr 
545                 550                 555                 560 


Arg Phe Ala Ser Phe Pro Asp Tyr Leu Val Ile Gln Ile Lys Lys Phe 
                565                 570                 575     


Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Leu Asp Val Ser Ile Glu 
            580                 585                 590         


Met Pro Glu Glu Leu Asp Ile Ser Gln Leu Arg Gly Thr Gly Leu Gln 
        595                 600                 605             


Pro Gly Glu Glu Glu Leu Pro Asp Ile Ala Pro Pro Leu Val Thr Pro 
    610                 615                 620                 


Asp Glu Pro Lys Ala Pro Met Leu Asp Glu Ser Val Ile Ile Gln Leu 
625                 630                 635                 640 


Val Glu Met Gly Phe Pro Met Asp Ala Cys Arg Lys Ala Val Tyr Tyr 
                645                 650                 655     


Thr Gly Asn Ser Gly Ala Glu Ala Ala Met Asn Trp Val Met Ser His 
            660                 665                 670         


Met Asp Asp Pro Asp Phe Ala Asn Pro Leu Ile Leu Pro Gly Ser Ser 
        675                 680                 685             


Gly Pro Gly Ser Thr Ser Ala Ala Ala Asp Pro Pro Pro Glu Asp Cys 
    690                 695                 700                 


Val Thr Thr Ile Val Ser Met Gly Phe Ser Arg Asp Gln Ala Leu Lys 
705                 710                 715                 720 


Ala Leu Arg Ala Thr Asn Asn Ser Leu Glu Arg Ala Val Asp Trp Ile 
                725                 730                 735     


Phe Ser His Ile Asp Asp Leu Asp Ala Glu Ala Ala Met Asp Ile Ser 
            740                 745                 750         


Glu Gly Arg Ser Ala Ala Asp Ser Ile Ser Glu Ser Val Pro Val Gly 
        755                 760                 765             


Pro Lys Val Arg Asp Gly Pro Gly Lys Tyr Gln Leu Phe Ala Phe Ile 
    770                 775                 780                 


Ser His Met Gly Thr Ser Thr Met Cys Gly His Tyr Val Cys His Ile 
785                 790                 795                 800 


Lys Lys Glu Gly Arg Trp Val Ile Tyr Asn Asp Gln Lys Val Cys Ala 
                805                 810                 815     


Ser Glu Lys Pro Pro Lys Asp Leu Gly Tyr Ile Tyr Phe Tyr Gln Arg 
            820                 825                 830         


Val Ala Ser 
        835 


<210>  34
<211>  3130
<212>  DNA
<213>  Homo sapiens

<400>  34
ggggactggg aacggtggga gccgccgtgt gtggagaagc tgctgccggt gtcatggcgg     60

agctgagtga ggaggcgctg ctgtcagtat taccgacgat ccgggtccct aaggctggag    120

accgggtcca caaagacgag tgcgccttct ccttcgacac gccggagtct gaggggggcc    180

tctacatctg tatgaacacg tttctgggct ttgggaaaca gtatgtggag agacatttca    240

ataagaccgg ccagcgagtc tacttgcacc tccggcggac ccggcgcccg aaagaggagg    300

accctgctac aggcactgga gacccacccc ggaagaagcc cacgcggctg gctattggtg    360

ttgaaggcgg atttgacctt agcgaggaga agtttgaatt agacgaggat gtgaagattg    420

tcattttgcc agattacctg gagattgccc gggatggact ggggggactg cctgacattg    480

tcagagatcg ggtgaccagt gcagtggagg ccctactgtc ggccgactca gcctcccgca    540

agcaggaggt gcaggcatgg gatggggaag tacggcaggt gtctaagcat gccttcagcc    600

tcaagcagtt ggacaaccct gctcgaatcc ctccctgtgg ctggaagtgc tccaagtgtg    660

acatgagaga gaacctgtgg ctcaacctga ctgatggctc catcctctgt gggcgacgct    720

acttcgatgg cagtgggggc aacaaccacg ctgtggagca ctaccgagag acaggctacc    780

cgttagctgt caagctgggc accatcaccc ctgatggagc tgacgtgtac tcatatgatg    840

aggatgacat ggtcctggac cccagcctgg ctgagcacct gtcccacttc ggcatcgaca    900

tgctgaagat gcagaagaca gacaagacga tgactgagtt ggagatagac atgaaccagc    960

ggattggtga atgggagctg atccaggagt caggtgtgcc actcaagccc ctgtttgggc   1020

ctggctacac aggcatccgg aacctgggta acagctgcta cctcaactct gtggtccagg   1080

tgctcttcag catccctgac ttccagagga agtatgtgga taagctggag aagatcttcc   1140

agaatgcccc gacggaccct acccaggatt tcagcaccca ggtggccaag ctgggccatg   1200

gccttctctc cggggagtat tccaagccag taccggagtc gggcgatggg gagcgggtgc   1260

cagaacagaa ggaagttcaa gatggcattg cccctcggat gttcaaggcc ctcatcggca   1320

agggccaccc tgaattctcc accaaccggc agcaggatgc ccaggagttc ttccttcacc   1380

ttatcaacat ggtggagagg aattgccgga gctctgaaaa tcctaatgaa gtgttccgct   1440

tcttggtgga ggaaaagatc aagtgcctgg ccacagagaa ggtgaagtac acccagcgag   1500

ttgactacat catgcagctg cctgtgccca tggatgcagc ccttaacaaa gaggagcttc   1560

tggagtacga ggagaagaag cggcaagccg aagaggagaa gatggcactg ccagaactgg   1620

ttcgggccca ggtgcccttc agctcttgcc tggaggccta cggggcccct gagcaggtcg   1680

atgacttctg gagcacggcc ctgcaggcca agtcagtagc tgtcaagacc acacgatttg   1740

cctcattccc tgactacctg gtcatccaga tcaagaagtt caccttcggc ttagactggg   1800

tgcccaagaa actggatgtg tccatcgaga tgccagagga gctcgacatc tcccagttga   1860

ggggcacagg gctgcagccc ggagaggagg agctgccaga cattgcccca cccctggtca   1920

ctccggatga gcccaaagcg cccatgctgg atgaatcagt catcatccag ctggtggaga   1980

tgggattccc tatggacgcc tgccgcaaag ctgtctacta cacgggcaac agcggggctg   2040

aggccgccat gaactgggtc atgtcacaca tggatgatcc agattttgca aaccccctca   2100

tcctgcctgg ctctagtggg ccgggctcca caagcgcagc agccgacccc cctcctgagg   2160

actgtgtgac caccattgtc tccatgggct tctcccggga ccaggccttg aaagcgctgc   2220

gggccacgaa caatagttta gaacgggctg tggactggat cttcagtcac attgacgacc   2280

tggatgctga agctgccatg gacatctcag agggccgctc agctgccgac tccatctctg   2340

agtctgtgcc agtgggacct aaagtccggg atggtcctgg aaagtatcag ctctttgcct   2400

tcattagtca catgggcacc tctaccatgt gtggtcacta cgtctgccac atcaagaaag   2460

aaggcagatg ggtgatctac aatgaccaga aagtgtgtgc ctccgagaag ccgcccaagg   2520

acctgggcta catctacttc taccagagag tggccagcta agagcctgcc tcacccctta   2580

ccaatgaggg caggggaaga ccacctggca tgagggagag gggctgaggg atggacttca   2640

gcccctctgc tctgtaccct ttttcctttt gtccccggca gcagggaaga agctggaggc   2700

cgtgggagaa tggctgggca gagcagaggg gcagcgatag actctgggga tggagcagga   2760

cggggacggg aggggccggc cacctgtctg taaggagact ttgttgcttc ccctgccccc   2820

ggaatccaca gtgctctgct tctctgtgtc gccccgccca gccccctggt gtggagggag   2880

gggtctcgtt tgtgcgcgtg ggtgtagctt tgtgcatcct ctcccagtgg agcgatcacc   2940

tgtgcctccc ctcccccttt gtttgcccct gtgtggttgg tcaaggaggg atgtgaggga   3000

aatagggacc ccccgacttg ccctcctgcc tcagtctttc ccccaccctg tctcttcctt   3060

gtccttctct ggaaaatgcc aaaatacacg atgtgaataa aagtacaacg gctaaaaaaa   3120

aaaaaaaaaa                                                          3130


<210>  35
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser Glu Tyr 
            20                  25                  30          


Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile Gly Gly 
        35                  40                  45              


Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Val 
65                  70                  75                  80  


Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                85                  90                  95      


Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe Leu Leu 
            100                 105                 110         


Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile Glu Lys 
        115                 120                 125             


Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys 
    130                 135                 140                 


Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Arg Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                165                 170                 175     


Leu Glu Pro Pro Glu Thr Gln Pro Lys Arg Lys Cys Cys Ile Phe 
            180                 185                 190     


<210>  36
<211>  1530
<212>  DNA
<213>  Homo sapiens

<400>  36
acttccgcgg gcacccaact gtgcgtctcc tgcgcgctga cgtcaggtgc gtgcccctgt     60

ccggcagccg aggagacccc gcgcagtgct gccaacgccc cggtggagaa gctgaggtca    120

tcatcagatt tgaaatattt aaagtggata caaaactatt tcagcaatgc agacaattaa    180

gtgtgttgtt gtgggcgatg gtgctgttgg taaaacatgt ctcctgatat cctacacaac    240

aaacaaattt ccatcggaat atgtaccgac tgtttttgac aactatgcag tcacagttat    300

gattggtgga gaaccatata ctcttggact ttttgatact gcagggcaag aggattatga    360

cagattacga ccgctgagtt atccacaaac agatgtattt ctagtctgtt tttcagtggt    420

ctctccatct tcatttgaaa acgtgaaaga aaagtgggtg cctgagataa ctcaccactg    480

tccaaagact cctttcttgc ttgttgggac tcaaattgat ctcagagatg acccctctac    540

tattgagaaa cttgccaaga acaaacagaa gcctatcact ccagagactg ctgaaaagct    600

ggcccgtgac ctgaaggctg tcaagtatgt ggagtgttct gcacttacac agagaggtct    660

gaagaatgtg tttgatgagg ctatcctagc tgccctcgag cctccggaaa ctcaacccaa    720

aaggaagtgc tgtatattct aaactgtttt ctccttccct tctttgctgc tgcttcctgt    780

cccactactg tagaaagatc gtttaaaaac aaaggaataa aaccatcctg tttgaaagcc    840

tctgcgtctt tttactcacc accttagagc aacctctgta ttagtttttg atcaagaatg    900

caatatcata taaatttttt gtgatcagta gtcaagttgg acttgtttta acgttctgct    960

gcttgagttg cctgatgctc agagcttttt ggtttggatt actattgcaa aagggaactt   1020

ggtctggctt taagaatgtc ctcttggaga aaataacaag agttttaaca cttctagatc   1080

ttagttctag atggagaaag taacacaaac atcattttac tcttatgatc aattgttaat   1140

tgtaattgca tgacaaacct tatggaaaag gggtgaccta gtagagtgta atggggaagg   1200

gaggattctt ttctggtttt cctttgtgcg gtgaaacttt gtgttgctgt tgctttggct   1260

gtctgtgctg tagtggagta tttgtcagtc tggggtgggg aagatattga tgtatctgct   1320

actgctttat gagttcattt gttacattat cttttaagaa taacatccat ttaaacagtt   1380

gacttacagt ttgttaatgc tgagatgtaa agctgccacc tttatatttt cctgcttctg   1440

attttattgt gagggaaata tacaattgtg gttaccttca aattttgaaa ttaaaaatat   1500

acaaccgttt gtaaaaaaaa aaaaaaaaaa                                    1530


<210>  37
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser Glu Tyr 
            20                  25                  30          


Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile Gly Gly 
        35                  40                  45              


Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Val 
65                  70                  75                  80  


Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                85                  90                  95      


Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe Leu Leu 
            100                 105                 110         


Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile Glu Lys 
        115                 120                 125             


Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys 
    130                 135                 140                 


Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Lys Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                165                 170                 175     


Leu Glu Pro Pro Glu Pro Lys Lys Ser Arg Arg Cys Val Leu Leu 
            180                 185                 190     


<210>  38
<211>  2308
<212>  DNA
<213>  Homo sapiens

<400>  38
acttccgcgg gcacccaact gtgcgtctcc tgcgcgctga cgtcaggtgc gtgcccctgt     60

ccggcagccg aggagacccc gcgcagtgct gccaacgccc cggtggagaa gctgagacgg    120

agtctcactg tgttgcccag gctggagtgc agtggcgcca tcttggctca ctgcagtgcg    180

cctctgcccc ccgagttcaa gcgattctcc tgcctcaggc tcctgagtag ctgggactac    240

aggtcatcat cagatttgaa atatttaaag tggatacaaa actatttcag caatgcagac    300

aattaagtgt gttgttgtgg gcgatggtgc tgttggtaaa acatgtctcc tgatatccta    360

cacaacaaac aaatttccat cggaatatgt accgactgtt tttgacaact atgcagtcac    420

agttatgatt ggtggagaac catatactct tggacttttt gatactgcag ggcaagagga    480

ttatgacaga ttacgaccgc tgagttatcc acaaacagat gtatttctag tctgtttttc    540

agtggtctct ccatcttcat ttgaaaacgt gaaagaaaag tgggtgcctg agataactca    600

ccactgtcca aagactcctt tcttgcttgt tgggactcaa attgatctca gagatgaccc    660

ctctactatt gagaaacttg ccaagaacaa acagaagcct atcactccag agactgctga    720

aaagctggcc cgtgacctga aggctgtcaa gtatgtggag tgttctgcac ttacacagaa    780

aggcctaaag aatgtatttg acgaagcaat attggctgcc ctggagcctc cagaaccgaa    840

gaagagccgc aggtgtgtgc tgctatgaac atctctccag agccctttct gcacagctgg    900

tgtcggcatc atactaaaag caatgtttaa atcaaactaa agattaaaaa ttaaaattcg    960

tttttgcaat aatgacaaat gccctgcacc tacccacatg cactcgtgtg agacaaggcc   1020

cataggtatg gcccccccct tccccctccc agtactagtt aattttgagt aattgtattg   1080

tcagaaaagt gattagtact attttttttt gttgtttcaa aaaaaaaatt tttgtgtgtg   1140

tgtgtttttt tttttttttt ttttgttgtt taaaagcaag gcatgcttgt ggatgactct   1200

gtaacagact aattggaatt gttgaagctg ctccctggtt ccactctgga gagtaatctg   1260

ggacatctta gtgttttgtt ttgttttttt ccctcctctt ttttttgggg gggagtgtgt   1320

gtggggtttg ttttttagtc ttgttttttt aattcattaa ccagtggtta gcccttaagg   1380

ggaggaggac ggattgattc cacattccac ttcctagatc tagtttagaa aacatgttcc   1440

ccatctggtg ctcttaggaa ggagtatagt aaatgcctca tttaataaca tactcctttt   1500

tgaaagttgc cttttctctc cacccttgag tagatccagt atttgatgaa actcatgaaa   1560

gtgggtggag cccatcttgc ccctcctctt ttctaggacg cactatatgt gactgtgact   1620

ttcaaggaca tttgtttgcc atttgctgat ttttttggga agttaatttc taacttcttt   1680

cactgataaa tgaagaaaag tattgcacct ttgaaatgca ccaaatgaat tgagtttgta   1740

attaaaaaaa tttttttccc tttcagtcat tgtcttatat gcttagcata gatttgcagc   1800

tcagtagtat atggtgttcc tagaatgcag ctgaagacct gttatgtaga ggaaatacga   1860

ggggtggtgc tagaagacag acatctgtgg aatgattcac atcctctcaa gttaggagga   1920

tggaggcctg cttcattaag aagctggggg tagggtgggg gtggggagaa cacttaacaa   1980

catggggacc agtcagggga atccccttat ttctgttttg catatgagga accctagagc   2040

agccaggtga ggctctctag tttaataaaa atcatggaaa gactcttaat gcagactctt   2100

cttaagtgtt aatagggatt ttttcagctt attttggttg cagtttccaa tttttaaaaa   2160

tgttgaggta atctttccca ccttcccaaa cctaattctt gtagatgcat tagtgttgaa   2220

ccaatgcttt ctcatgtctc aattctttgt atatgcattc ttttcagatg tattaaacaa   2280

acaaaaaccc ttcaaaaaaa aaaaaaaa                                      2308


