                         SEQUENCE LISTING

<110>  Emory University
       Srinivasan, Shanthi
 
<120>  GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR, OBESITY, AND 
       OBESITY-RELATED DISEASES AND CONDITIONS

<130>  11119 PCT

<150>  US 61/503,120
<151>  2011-06-30

<150>  US 61/482,880
<151>  2011-05-05

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  211
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(211)
<223>  Human GDNF

<400>  1

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  2
<211>  185
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(185)
<223>  Human GDNF

<400>  2

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Ala Asn Met Pro Glu Asp Tyr Pro 
            20                  25                  30          


Asp Gln Phe Asp Asp Val Met Asp Phe Ile Gln Ala Thr Ile Lys Arg 
        35                  40                  45              


Leu Lys Arg Ser Pro Asp Lys Gln Met Ala Val Leu Pro Arg Arg Glu 
    50                  55                  60                  


Arg Asn Arg Gln Ala Ala Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys 
65                  70                  75                  80  


Gly Arg Arg Gly Gln Arg Gly Lys Asn Arg Gly Cys Val Leu Thr Ala 
                85                  90                  95      


Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu 
            100                 105                 110         


Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr 
        115                 120                 125             


Thr Tyr Asp Lys Ile Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu Val 
    130                 135                 140                 


Ser Asp Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp 
145                 150                 155                 160 


Asp Leu Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg Lys 
                165                 170                 175     


His Ser Ala Lys Arg Cys Gly Cys Ile 
            180                 185 


<210>  3
<211>  228
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(228)
<223>  Human GDNF

<400>  3

Met Gln Ser Leu Pro Asn Ser Asn Gly Ala Ala Ala Gly Arg Asp Phe 
1               5                   10                  15      


Lys Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His 
            20                  25                  30          


Thr Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala 
        35                  40                  45              


Pro Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu 
    50                  55                  60                  


Ser Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp 
65                  70                  75                  80  


Val Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro 
                85                  90                  95      


Asp Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala 
            100                 105                 110         


Ala Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln 
        115                 120                 125             


Arg Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val 
    130                 135                 140                 


Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg 
145                 150                 155                 160 


Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile 
                165                 170                 175     


Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly 
            180                 185                 190         


Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu 
        195                 200                 205             


Asp Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg 
    210                 215                 220                 


Cys Gly Cys Ile 
225             


<210>  4
<211>  202
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(202)
<223>  Human GDNF

<400>  4

Met Gln Ser Leu Pro Asn Ser Asn Gly Ala Ala Ala Gly Arg Asp Phe 
1               5                   10                  15      


Lys Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His 
            20                  25                  30          


Thr Ala Ser Ala Phe Pro Leu Pro Ala Ala Asn Met Pro Glu Asp Tyr 
        35                  40                  45              


Pro Asp Gln Phe Asp Asp Val Met Asp Phe Ile Gln Ala Thr Ile Lys 
    50                  55                  60                  


Arg Leu Lys Arg Ser Pro Asp Lys Gln Met Ala Val Leu Pro Arg Arg 
65                  70                  75                  80  


Glu Arg Asn Arg Gln Ala Ala Ala Ala Asn Pro Glu Asn Ser Arg Gly 
                85                  90                  95      


Lys Gly Arg Arg Gly Gln Arg Gly Lys Asn Arg Gly Cys Val Leu Thr 
            100                 105                 110         


Ala Ile His Leu Asn Val Thr Asp Leu Gly Leu Gly Tyr Glu Thr Lys 
        115                 120                 125             


Glu Glu Leu Ile Phe Arg Tyr Cys Ser Gly Ser Cys Asp Ala Ala Glu 
    130                 135                 140                 


Thr Thr Tyr Asp Lys Ile Leu Lys Asn Leu Ser Arg Asn Arg Arg Leu 
145                 150                 155                 160 


Val Ser Asp Lys Val Gly Gln Ala Cys Cys Arg Pro Ile Ala Phe Asp 
                165                 170                 175     


Asp Asp Leu Ser Phe Leu Asp Asp Asn Leu Val Tyr His Ile Leu Arg 
            180                 185                 190         


Lys His Ser Ala Lys Arg Cys Gly Cys Ile 
        195                 200         


<210>  5
<211>  633
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Where CTT  = LEU

<220>
<221>  MISC_FEATURE
<223>  Where CCG = PRO

<220>
<221>  MISC_FEATURE
<223>  Where GAG = GLU

<400>  5

Met Glu Thr Leu Tyr Ser Cys Thr Thr Thr Arg Pro Ala Ser Pro Val 
1               5                   10                  15      


Ala Leu Val Ala Leu Ala Leu Ala Val Ala Leu Cys Tyr Ser Cys Thr 
            20                  25                  30          


Thr Val Ala Leu Cys Thr Thr Cys Thr Thr His Ile Ser Thr His Arg 
        35                  40                  45              


Ala Leu Ala Ser Glu Arg Ala Leu Ala Pro His Glu Cys Cys Cys Cys 
    50                  55                  60                  


Thr Thr Cys Cys Cys Ala Leu Ala Gly Leu Tyr Leu Tyr Ser Ala Arg 
65                  70                  75                  80  


Gly Cys Cys Cys Cys Cys Cys Gly Ala Gly Ala Leu Ala Cys Cys Cys 
                85                  90                  95      


Ala Leu Ala Gly Ala Gly Ala Ser Pro Ala Arg Gly Ser Glu Arg Cys 
            100                 105                 110         


Thr Thr Gly Leu Tyr Ala Arg Gly Ala Arg Gly Ala Arg Gly Ala Leu 
        115                 120                 125             


Ala Cys Cys Cys Pro His Glu Ala Leu Ala Cys Thr Thr Ser Glu Arg 
    130                 135                 140                 


Ser Glu Arg Ala Ser Pro Ser Glu Arg Ala Ser Asn Met Glu Thr Cys 
145                 150                 155                 160 


Cys Cys Gly Ala Gly Ala Ser Pro Thr Tyr Arg Cys Cys Cys Ala Ser 
                165                 170                 175     


Pro Gly Leu Asn Pro His Glu Ala Ser Pro Ala Ser Pro Val Ala Leu 
            180                 185                 190         


Met Glu Thr Ala Ser Pro Pro His Glu Ile Leu Glu Gly Leu Asn Ala 
        195                 200                 205             


Leu Ala Thr His Arg Ile Leu Glu Leu Tyr Ser Ala Arg Gly Cys Thr 
    210                 215                 220                 


Thr Leu Tyr Ser Ala Arg Gly Ser Glu Arg Cys Cys Cys Ala Ser Pro 
225                 230                 235                 240 


Leu Tyr Ser Gly Leu Asn Met Glu Thr Ala Leu Ala Val Ala Leu Cys 
                245                 250                 255     


Thr Thr Cys Cys Cys Ala Arg Gly Ala Arg Gly Gly Ala Gly Ala Arg 
            260                 265                 270         


Gly Ala Ser Asn Ala Arg Gly Gly Leu Asn Ala Leu Ala Ala Leu Ala 
        275                 280                 285             


Ala Leu Ala Ala Leu Ala Ala Ser Asn Cys Cys Cys Gly Ala Gly Ala 
    290                 295                 300                 


Ser Asn Ser Glu Arg Ala Arg Gly Gly Leu Tyr Leu Tyr Ser Gly Leu 
305                 310                 315                 320 


Tyr Ala Arg Gly Ala Arg Gly Gly Leu Tyr Gly Leu Asn Ala Arg Gly 
                325                 330                 335     


Gly Leu Tyr Leu Tyr Ser Ala Ser Asn Ala Arg Gly Gly Leu Tyr Cys 
            340                 345                 350         


Tyr Ser Val Ala Leu Cys Thr Thr Thr His Arg Ala Leu Ala Ile Leu 
        355                 360                 365             


Glu His Ile Ser Cys Thr Thr Ala Ser Asn Val Ala Leu Thr His Arg 
    370                 375                 380                 


Ala Ser Pro Cys Thr Thr Gly Leu Tyr Cys Thr Thr Gly Leu Tyr Thr 
385                 390                 395                 400 


Tyr Arg Gly Ala Gly Thr His Arg Leu Tyr Ser Gly Ala Gly Gly Ala 
                405                 410                 415     


Gly Cys Thr Thr Ile Leu Glu Pro His Glu Ala Arg Gly Thr Tyr Arg 
            420                 425                 430         


Cys Tyr Ser Ser Glu Arg Gly Leu Tyr Ser Glu Arg Cys Tyr Ser Ala 
        435                 440                 445             


Ser Pro Ala Leu Ala Ala Leu Ala Gly Ala Gly Thr His Arg Thr His 
    450                 455                 460                 


Arg Thr Tyr Arg Ala Ser Pro Leu Tyr Ser Ile Leu Glu Cys Thr Thr 
465                 470                 475                 480 


Leu Tyr Ser Ala Ser Asn Cys Thr Thr Ser Glu Arg Ala Arg Gly Ala 
                485                 490                 495     


Ser Asn Ala Arg Gly Ala Arg Gly Cys Thr Thr Val Ala Leu Thr His 
            500                 505                 510         


Arg Ala Ser Pro Leu Tyr Ser Val Ala Leu Gly Leu Tyr Gly Leu Asn 
        515                 520                 525             


Ala Leu Ala Cys Tyr Ser Cys Tyr Ser Ala Arg Gly Cys Cys Cys Ile 
    530                 535                 540                 


Leu Glu Ala Leu Ala Pro His Glu Ala Ser Pro Ala Ser Pro Ala Ser 
545                 550                 555                 560 


Pro Cys Thr Thr Ser Glu Arg Pro His Glu Cys Thr Thr Ala Ser Pro 
                565                 570                 575     


Ala Ser Pro Ala Ser Asn Cys Thr Thr Val Ala Leu Thr Tyr Arg His 
            580                 585                 590         


Ile Ser Ile Leu Glu Cys Thr Thr Ala Arg Gly Leu Tyr Ser His Ile 
        595                 600                 605             


Ser Ser Glu Arg Ala Leu Ala Leu Tyr Ser Ala Arg Gly Cys Tyr Ser 
    610                 615                 620                 


Gly Leu Tyr Cys Tyr Ser Ile Leu Glu 
625                 630             


<210>  6
<211>  633
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Where CTT = LEU

<220>
<221>  MISC_FEATURE
<223>  Where CCG = PRO

<220>
<221>  MISC_FEATURE
<223>  Where GAG = GLU

<400>  6

Met Glu Thr Leu Tyr Ser Cys Thr Thr Thr Arg Pro Ala Ser Pro Val 
1               5                   10                  15      


Ala Leu Val Ala Leu Ala Leu Ala Val Ala Leu Cys Tyr Ser Cys Thr 
            20                  25                  30          


Thr Val Ala Leu Cys Thr Thr Cys Thr Thr His Ile Ser Thr His Arg 
        35                  40                  45              


Ala Leu Ala Ser Glu Arg Ala Leu Ala Pro His Glu Cys Cys Gly Cys 
    50                  55                  60                  


Thr Thr Cys Cys Gly Ala Leu Ala Gly Leu Tyr Leu Tyr Ser Ala Arg 
65                  70                  75                  80  


Gly Cys Thr Thr Cys Thr Thr Gly Ala Gly Ala Leu Ala Cys Cys Gly 
                85                  90                  95      


Ala Leu Ala Gly Ala Gly Ala Ser Pro His Ile Ser Ser Glu Arg Cys 
            100                 105                 110         


Thr Thr Gly Leu Tyr His Ile Ser Ala Arg Gly Ala Arg Gly Val Ala 
        115                 120                 125             


Leu Cys Cys Gly Pro His Glu Ala Leu Ala Cys Thr Thr Thr His Arg 
    130                 135                 140                 


Ser Glu Arg Ala Ser Pro Ser Glu Arg Ala Ser Asn Met Glu Thr Cys 
145                 150                 155                 160 


Cys Gly Gly Ala Gly Ala Ser Pro Thr Tyr Arg Cys Cys Gly Ala Ser 
                165                 170                 175     


Pro Gly Leu Asn Pro His Glu Ala Ser Pro Ala Ser Pro Val Ala Leu 
            180                 185                 190         


Met Glu Thr Ala Ser Pro Pro His Glu Ile Leu Glu Gly Leu Asn Ala 
        195                 200                 205             


Leu Ala Thr His Arg Ile Leu Glu Leu Tyr Ser Ala Arg Gly Cys Thr 
    210                 215                 220                 


Thr Leu Tyr Ser Ala Arg Gly Ser Glu Arg Cys Cys Gly Ala Ser Pro 
225                 230                 235                 240 


Leu Tyr Ser Gly Leu Asn Ala Leu Ala Ala Leu Ala Ala Leu Ala Cys 
                245                 250                 255     


Thr Thr Cys Cys Gly Ala Arg Gly Ala Arg Gly Gly Ala Gly Ala Arg 
            260                 265                 270         


Gly Ala Ser Asn Ala Arg Gly Gly Leu Asn Ala Leu Ala Ala Leu Ala 
        275                 280                 285             


Ala Leu Ala Ala Leu Ala Ser Glu Arg Cys Cys Gly Gly Ala Gly Ala 
    290                 295                 300                 


Ser Asn Ser Glu Arg Ala Arg Gly Gly Leu Tyr Leu Tyr Ser Gly Leu 
305                 310                 315                 320 


Tyr Ala Arg Gly Ala Arg Gly Gly Leu Tyr Gly Leu Asn Ala Arg Gly 
                325                 330                 335     


Gly Leu Tyr Leu Tyr Ser Ala Ser Asn Ala Arg Gly Gly Leu Tyr Cys 
            340                 345                 350         


Tyr Ser Val Ala Leu Cys Thr Thr Thr His Arg Ala Leu Ala Ile Leu 
        355                 360                 365             


Glu His Ile Ser Cys Thr Thr Ala Ser Asn Val Ala Leu Thr His Arg 
    370                 375                 380                 


Ala Ser Pro Cys Thr Thr Gly Leu Tyr Cys Thr Thr Gly Leu Tyr Thr 
385                 390                 395                 400 


Tyr Arg Gly Ala Gly Thr His Arg Leu Tyr Ser Gly Ala Gly Gly Ala 
                405                 410                 415     


Gly Cys Thr Thr Ile Leu Glu Pro His Glu Ala Arg Gly Thr Tyr Arg 
            420                 425                 430         


Cys Tyr Ser Ser Glu Arg Gly Leu Tyr Ser Glu Arg Cys Tyr Ser Gly 
        435                 440                 445             


Ala Gly Ala Leu Ala Ala Leu Ala Gly Ala Gly Thr His Arg Met Glu 
    450                 455                 460                 


Thr Thr Tyr Arg Ala Ser Pro Leu Tyr Ser Ile Leu Glu Cys Thr Thr 
465                 470                 475                 480 


Leu Tyr Ser Ala Ser Asn Cys Thr Thr Ser Glu Arg Ala Arg Gly Ser 
                485                 490                 495     


Glu Arg Ala Arg Gly Ala Arg Gly Cys Thr Thr Thr His Arg Ser Glu 
            500                 505                 510         


Arg Ala Ser Pro Leu Tyr Ser Val Ala Leu Gly Leu Tyr Gly Leu Asn 
        515                 520                 525             


Ala Leu Ala Cys Tyr Ser Cys Tyr Ser Ala Arg Gly Cys Cys Gly Val 
    530                 535                 540                 


Ala Leu Ala Leu Ala Pro His Glu Ala Ser Pro Ala Ser Pro Ala Ser 
545                 550                 555                 560 


Pro Cys Thr Thr Ser Glu Arg Pro His Glu Cys Thr Thr Ala Ser Pro 
                565                 570                 575     


Ala Ser Pro Ser Glu Arg Cys Thr Thr Val Ala Leu Thr Tyr Arg His 
            580                 585                 590         


Ile Ser Ile Leu Glu Cys Thr Thr Ala Arg Gly Leu Tyr Ser His Ile 
        595                 600                 605             


Ser Ser Glu Arg Ala Leu Ala Leu Tyr Ser Ala Arg Gly Cys Tyr Ser 
    610                 615                 620                 


Gly Leu Tyr Cys Tyr Ser Ile Leu Glu 
625                 630             


<210>  7
<211>  402
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Where CTT = LEU

<220>
<221>  MISC_FEATURE
<223>  Where CCG = PRO

<220>
<221>  MISC_FEATURE
<223>  Where GAG = GLU

<400>  7

Ser Glu Arg Cys Cys Gly Ala Ser Pro Leu Tyr Ser Gly Leu Asn Met 
1               5                   10                  15      


Glu Thr Ala Leu Ala Val Ala Leu Cys Thr Thr Cys Cys Gly Ala Arg 
            20                  25                  30          


Gly Ala Arg Gly Gly Ala Gly Ala Arg Gly Ala Ser Asn Ala Arg Gly 
        35                  40                  45              


Gly Leu Asn Ala Leu Ala Ala Leu Ala Ala Leu Ala Ala Leu Ala Ala 
    50                  55                  60                  


Ser Asn Cys Cys Gly Gly Ala Gly Ala Ser Asn Ser Glu Arg Ala Arg 
65                  70                  75                  80  


Gly Gly Leu Tyr Leu Tyr Ser Gly Leu Tyr Ala Arg Gly Ala Arg Gly 
                85                  90                  95      


Gly Leu Tyr Gly Leu Asn Ala Arg Gly Gly Leu Tyr Leu Tyr Ser Ala 
            100                 105                 110         


Ser Asn Ala Arg Gly Gly Leu Tyr Cys Tyr Ser Val Ala Leu Cys Thr 
        115                 120                 125             


Thr Thr His Arg Ala Leu Ala Ile Leu Glu His Ile Ser Cys Thr Thr 
    130                 135                 140                 


Ala Ser Asn Val Ala Leu Thr His Arg Ala Ser Pro Cys Thr Thr Gly 
145                 150                 155                 160 


Leu Tyr Cys Thr Thr Gly Leu Tyr Thr Tyr Arg Gly Ala Gly Thr His 
                165                 170                 175     


Arg Leu Tyr Ser Gly Ala Gly Gly Ala Gly Cys Thr Thr Ile Leu Glu 
            180                 185                 190         


Pro His Glu Ala Arg Gly Thr Tyr Arg Cys Tyr Ser Ser Glu Arg Gly 
        195                 200                 205             


Leu Tyr Ser Glu Arg Cys Tyr Ser Ala Ser Pro Ala Leu Ala Ala Leu 
    210                 215                 220                 


Ala Gly Ala Gly Thr His Arg Thr His Arg Thr Tyr Arg Ala Ser Pro 
225                 230                 235                 240 


Leu Tyr Ser Ile Leu Glu Cys Thr Thr Leu Tyr Ser Ala Ser Asn Cys 
                245                 250                 255     


Thr Thr Ser Glu Arg Ala Arg Gly Ala Ser Asn Ala Arg Gly Ala Arg 
            260                 265                 270         


Gly Cys Thr Thr Val Ala Leu Thr His Arg Ala Ser Pro Leu Tyr Ser 
        275                 280                 285             


Val Ala Leu Gly Leu Tyr Gly Leu Asn Ala Leu Ala Cys Tyr Ser Cys 
    290                 295                 300                 


Tyr Ser Ala Arg Gly Cys Cys Gly Ile Leu Glu Ala Leu Ala Pro His 
305                 310                 315                 320 


Glu Ala Ser Pro Ala Ser Pro Ala Ser Pro Cys Thr Thr Ser Glu Arg 
                325                 330                 335     


Pro His Glu Cys Thr Thr Ala Ser Pro Ala Ser Pro Ala Ser Asn Cys 
            340                 345                 350         


Thr Thr Val Ala Leu Thr Tyr Arg His Ile Ser Ile Leu Glu Cys Thr 
        355                 360                 365             


Thr Ala Arg Gly Leu Tyr Ser His Ile Ser Ser Glu Arg Ala Leu Ala 
    370                 375                 380                 


Leu Tyr Ser Ala Arg Gly Cys Tyr Ser Gly Leu Tyr Cys Tyr Ser Ile 
385                 390                 395                 400 


Leu Glu 
        


<210>  8
<211>  342
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Where CTT = LEU

<220>
<221>  MISC_FEATURE
<223>  Where CCG = PRO

<220>
<221>  MISC_FEATURE
<223>  Where GAG = GLU

<400>  8

Met Glu Thr Ser Glu Arg Cys Cys Gly Gly Ala Gly Ala Ser Asn Ser 
1               5                   10                  15      


Glu Arg Ala Arg Gly Gly Leu Tyr Leu Tyr Ser Gly Leu Tyr Ala Arg 
            20                  25                  30          


Gly Ala Arg Gly Gly Leu Tyr Gly Leu Asn Ala Arg Gly Gly Leu Tyr 
        35                  40                  45              


Leu Tyr Ser Ala Ser Asn Ala Arg Gly Gly Leu Tyr Cys Tyr Ser Val 
    50                  55                  60                  


Ala Leu Cys Thr Thr Thr His Arg Ala Leu Ala Ile Leu Glu His Ile 
65                  70                  75                  80  


Ser Cys Thr Thr Ala Ser Asn Val Ala Leu Thr His Arg Ala Ser Pro 
                85                  90                  95      


Cys Thr Thr Gly Leu Tyr Cys Thr Thr Gly Leu Tyr Thr Tyr Arg Gly 
            100                 105                 110         


Ala Gly Thr His Arg Ala Ser Asn Gly Ala Gly Gly Ala Gly Cys Thr 
        115                 120                 125             


Thr Ile Leu Glu Pro His Glu Ala Arg Gly Thr Tyr Arg Cys Tyr Ser 
    130                 135                 140                 


Ser Glu Arg Gly Leu Tyr Ser Glu Arg Cys Tyr Ser Ala Ser Pro Ala 
145                 150                 155                 160 


Leu Ala Ala Leu Ala Gly Ala Gly Thr His Arg Thr His Arg Thr Tyr 
                165                 170                 175     


Arg Ala Ser Pro Leu Tyr Ser Ile Leu Glu Cys Thr Thr Leu Tyr Ser 
            180                 185                 190         


Ala Ser Asn Cys Thr Thr Ser Glu Arg Ala Arg Gly Ala Ser Asn Ala 
        195                 200                 205             


Arg Gly Ala Arg Gly Cys Thr Thr Val Ala Leu Thr His Arg Ala Ser 
    210                 215                 220                 


Pro Leu Tyr Ser Val Ala Leu Gly Leu Tyr Gly Leu Asn Ala Leu Ala 
225                 230                 235                 240 


Cys Tyr Ser Cys Tyr Ser Ala Arg Gly Cys Cys Gly Ile Leu Glu Ala 
                245                 250                 255     


Leu Ala Pro His Glu Ala Ser Pro Ala Ser Pro Ala Ser Pro Cys Thr 
            260                 265                 270         


Thr Ser Glu Arg Pro His Glu Cys Thr Thr Ala Ser Pro Ala Ser Pro 
        275                 280                 285             


Ala Ser Asn Cys Thr Thr Val Ala Leu Thr Tyr Arg His Ile Ser Ile 
    290                 295                 300                 


Leu Glu Cys Thr Thr Ala Arg Gly Leu Tyr Ser His Ile Ser Ser Glu 
305                 310                 315                 320 


Arg Ala Leu Ala Leu Tyr Ser Ala Arg Gly Cys Tyr Ser Gly Leu Tyr 
                325                 330                 335     


Cys Tyr Ser Ile Leu Glu 
            340         


<210>  9
<211>  309
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Where CTT = LEU

<220>
<221>  MISC_FEATURE
<223>  Where CCG = PRO

<220>
<221>  MISC_FEATURE
<223>  Where GAg = GLU

<400>  9

Ala Arg Gly Gly Leu Tyr Gly Leu Asn Ala Arg Gly Gly Leu Tyr Leu 
1               5                   10                  15      


Tyr Ser Ala Ser Asn Ala Arg Gly Gly Leu Tyr Cys Tyr Ser Val Ala 
            20                  25                  30          


Leu Cys Thr Thr Thr His Arg Ala Leu Ala Ile Leu Glu His Ile Ser 
        35                  40                  45              


Cys Thr Thr Ala Ser Asn Val Ala Leu Thr His Arg Ala Ser Pro Cys 
    50                  55                  60                  


Thr Thr Gly Leu Tyr Cys Thr Thr Gly Leu Tyr Thr Tyr Arg Gly Ala 
65                  70                  75                  80  


Gly Thr His Arg Leu Tyr Ser Gly Ala Gly Gly Ala Gly Cys Thr Thr 
                85                  90                  95      


Ile Leu Glu Pro His Glu Ala Arg Gly Thr Tyr Arg Cys Tyr Ser Ser 
            100                 105                 110         


Glu Arg Gly Leu Tyr Ser Glu Arg Cys Tyr Ser Ala Ser Pro Ala Leu 
        115                 120                 125             


Ala Ala Leu Ala Gly Ala Gly Thr His Arg Thr His Arg Thr Tyr Arg 
    130                 135                 140                 


Ala Ser Pro Leu Tyr Ser Ile Leu Glu Cys Thr Thr Leu Tyr Ser Ala 
145                 150                 155                 160 


Ser Asn Cys Thr Thr Ser Glu Arg Ala Arg Gly Ala Ser Asn Ala Arg 
                165                 170                 175     


Gly Ala Arg Gly Cys Thr Thr Val Ala Leu Thr His Arg Ala Ser Pro 
            180                 185                 190         


Leu Tyr Ser Val Ala Leu Gly Leu Tyr Gly Leu Asn Ala Leu Ala Cys 
        195                 200                 205             


Tyr Ser Cys Tyr Ser Ala Arg Gly Gly Ala Gly Ile Leu Glu Ala Leu 
    210                 215                 220                 


Ala Pro His Glu Ala Ser Pro Ala Ser Pro Ala Ser Pro Cys Thr Thr 
225                 230                 235                 240 


Ser Glu Arg Pro His Glu Cys Thr Thr Ala Ser Pro Ala Ser Pro Ala 
                245                 250                 255     


Ser Asn Cys Thr Thr Val Ala Leu Thr Tyr Arg His Ile Ser Ile Leu 
            260                 265                 270         


Glu Cys Thr Thr Ala Arg Gly Leu Tyr Ser His Ile Ser Ser Glu Arg 
        275                 280                 285             


Ala Leu Ala Leu Tyr Ser Ala Arg Gly Cys Tyr Ser Gly Leu Tyr Cys 
    290                 295                 300                 


Tyr Ser Ile Leu Glu 
305                 


<210>  10
<211>  279
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Where CTT = LEU

<220>
<221>  MISC_FEATURE
<223>  Where CCG = PRO

<220>
<221>  MISC_FEATURE
<223>  Where GAg = GLU

<400>  10

Cys Tyr Ser Val Ala Leu Cys Thr Thr Thr His Arg Ala Leu Ala Ile 
1               5                   10                  15      


Leu Glu His Ile Ser Cys Thr Thr Ala Ser Asn Val Ala Leu Thr His 
            20                  25                  30          


Arg Ala Ser Pro Cys Thr Thr Gly Leu Tyr Cys Thr Thr Gly Leu Tyr 
        35                  40                  45              


Thr Tyr Arg Gly Ala Gly Thr His Arg Leu Tyr Ser Gly Ala Gly Gly 
    50                  55                  60                  


Ala Gly Cys Thr Thr Ile Leu Glu Pro His Glu Ala Arg Gly Thr Tyr 
65                  70                  75                  80  


Arg Cys Tyr Ser Ser Glu Arg Gly Leu Tyr Ser Glu Arg Cys Tyr Ser 
                85                  90                  95      


Ala Ser Pro Ala Leu Ala Ala Leu Ala Gly Ala Gly Thr His Arg Thr 
            100                 105                 110         


His Arg Thr Tyr Arg Ala Ser Pro Leu Tyr Ser Ile Leu Glu Cys Thr 
        115                 120                 125             


Thr Leu Tyr Ser Ala Ser Asn Cys Thr Thr Ser Glu Arg Ala Arg Gly 
    130                 135                 140                 


Ala Ser Asn Ala Arg Gly Ala Arg Gly Cys Thr Thr Val Ala Leu Thr 
145                 150                 155                 160 


His Arg Ala Ser Pro Leu Tyr Ser Val Ala Leu Gly Leu Tyr Gly Leu 
                165                 170                 175     


Asn Ala Leu Ala Cys Tyr Ser Cys Tyr Ser Ala Arg Gly Gly Ala Gly 
            180                 185                 190         


Ile Leu Glu Ala Leu Ala Pro His Glu Ala Ser Pro Ala Ser Pro Ala 
        195                 200                 205             


Ser Pro Cys Thr Thr Ser Glu Arg Pro His Glu Cys Thr Thr Ala Ser 
    210                 215                 220                 


Pro Ala Ser Pro Ala Ser Asn Cys Thr Thr Val Ala Leu Thr Tyr Arg 
225                 230                 235                 240 


His Ile Ser Ile Leu Glu Cys Thr Thr Ala Arg Gly Leu Tyr Ser His 
                245                 250                 255     


Ile Ser Ser Glu Arg Ala Leu Ala Leu Tyr Ser Ala Arg Gly Cys Tyr 
            260                 265                 270         


Ser Gly Leu Tyr Cys Tyr Ser 
        275                 


