                         SEQUENCE LISTING

<110>  Omeros Corporation
 
<120>  COMPOSITIONS FOR INHIBITING MASP-2 DEPENDENT COMPLEMENT 
       ACTIVATION

<130>  MP.1.0115.PCT

<150>  61/482567
<151>  2011-05-04

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  2460
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (22)..(2082)

<400>  1
ggccagctgg acgggcacac c atg agg ctg ctg acc ctc ctg ggc ctt ctg         51
                        Met Arg Leu Leu Thr Leu Leu Gly Leu Leu           
                        1               5                   10            

tgt ggc tcg gtg gcc acc ccc ttg ggc ccg aag tgg cct gaa cct gtg         99
Cys Gly Ser Val Ala Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro Val           
                15                  20                  25                

ttc ggg cgc ctg gca tcc ccc ggc ttt cca ggg gag tat gcc aat gac        147
Phe Gly Arg Leu Ala Ser Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp           
            30                  35                  40                    

cag gag cgg cgc tgg acc ctg act gca ccc ccc ggc tac cgc ctg cgc        195
Gln Glu Arg Arg Trp Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg           
        45                  50                  55                        

ctc tac ttc acc cac ttc gac ctg gag ctc tcc cac ctc tgc gag tac        243
Leu Tyr Phe Thr His Phe Asp Leu Glu Leu Ser His Leu Cys Glu Tyr           
    60                  65                  70                            

gac ttc gtc aag ctg agc tcg ggg gcc aag gtg ctg gcc acg ctg tgc        291
Asp Phe Val Lys Leu Ser Ser Gly Ala Lys Val Leu Ala Thr Leu Cys           
75                  80                  85                  90            

ggg cag gag agc aca gac acg gag cgg gcc cct ggc aag gac act ttc        339
Gly Gln Glu Ser Thr Asp Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe           
                95                  100                 105               

tac tcg ctg ggc tcc agc ctg gac att acc ttc cgc tcc gac tac tcc        387
Tyr Ser Leu Gly Ser Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser           
            110                 115                 120                   

aac gag aag ccg ttc acg ggg ttc gag gcc ttc tat gca gcc gag gac        435
Asn Glu Lys Pro Phe Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp           
        125                 130                 135                       

att gac gag tgc cag gtg gcc ccg gga gag gcg ccc acc tgc gac cac        483
Ile Asp Glu Cys Gln Val Ala Pro Gly Glu Ala Pro Thr Cys Asp His           
    140                 145                 150                           

cac tgc cac aac cac ctg ggc ggt ttc tac tgc tcc tgc cgc gca ggc        531
His Cys His Asn His Leu Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly           
155                 160                 165                 170           

tac gtc ctg cac cgt aac aag cgc acc tgc tca gcc ctg tgc tcc ggc        579
Tyr Val Leu His Arg Asn Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly           
                175                 180                 185               

cag gtc ttc acc cag agg tct ggg gag ctc agc agc cct gaa tac cca        627
Gln Val Phe Thr Gln Arg Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro           
            190                 195                 200                   

cgg ccg tat ccc aaa ctc tcc agt tgc act tac agc atc agc ctg gag        675
Arg Pro Tyr Pro Lys Leu Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu           
        205                 210                 215                       

gag ggg ttc agt gtc att ctg gac ttt gtg gag tcc ttc gat gtg gag        723
Glu Gly Phe Ser Val Ile Leu Asp Phe Val Glu Ser Phe Asp Val Glu           
    220                 225                 230                           

aca cac cct gaa acc ctg tgt ccc tac gac ttt ctc aag att caa aca        771
Thr His Pro Glu Thr Leu Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr           
235                 240                 245                 250           

gac aga gaa gaa cat ggc cca ttc tgt ggg aag aca ttg ccc cac agg        819
Asp Arg Glu Glu His Gly Pro Phe Cys Gly Lys Thr Leu Pro His Arg           
                255                 260                 265               

att gaa aca aaa agc aac acg gtg acc atc acc ttt gtc aca gat gaa        867
Ile Glu Thr Lys Ser Asn Thr Val Thr Ile Thr Phe Val Thr Asp Glu           
            270                 275                 280                   

tca gga gac cac aca ggc tgg aag atc cac tac acg agc aca gcg cag        915
Ser Gly Asp His Thr Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Gln           
        285                 290                 295                       

cct tgc cct tat ccg atg gcg cca cct aat ggc cac gtt tca cct gtg        963
Pro Cys Pro Tyr Pro Met Ala Pro Pro Asn Gly His Val Ser Pro Val           
    300                 305                 310                           

caa gcc aaa tac atc ctg aaa gac agc ttc tcc atc ttt tgc gag act       1011
Gln Ala Lys Tyr Ile Leu Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr           
315                 320                 325                 330           

ggc tat gag ctt ctg caa ggt cac ttg ccc ctg aaa tcc ttt act gca       1059
Gly Tyr Glu Leu Leu Gln Gly His Leu Pro Leu Lys Ser Phe Thr Ala           
                335                 340                 345               

gtt tgt cag aaa gat gga tct tgg gac cgg cca atg ccc gcg tgc agc       1107
Val Cys Gln Lys Asp Gly Ser Trp Asp Arg Pro Met Pro Ala Cys Ser           
            350                 355                 360                   

att gtt gac tgt ggc cct cct gat gat cta ccc agt ggc cga gtg gag       1155
Ile Val Asp Cys Gly Pro Pro Asp Asp Leu Pro Ser Gly Arg Val Glu           
        365                 370                 375                       

tac atc aca ggt cct gga gtg acc acc tac aaa gct gtg att cag tac       1203
Tyr Ile Thr Gly Pro Gly Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr           
    380                 385                 390                           

agc tgt gaa gag acc ttc tac aca atg aaa gtg aat gat ggt aaa tat       1251
Ser Cys Glu Glu Thr Phe Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr           
395                 400                 405                 410           

gtg tgt gag gct gat gga ttc tgg acg agc tcc aaa gga gaa aaa tca       1299
Val Cys Glu Ala Asp Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser           
                415                 420                 425               

ctc cca gtc tgt gag cct gtt tgt gga cta tca gcc cgc aca aca gga       1347
Leu Pro Val Cys Glu Pro Val Cys Gly Leu Ser Ala Arg Thr Thr Gly           
            430                 435                 440                   

ggg cgt ata tat gga ggg caa aag gca aaa cct ggt gat ttt cct tgg       1395
Gly Arg Ile Tyr Gly Gly Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp           
        445                 450                 455                       

caa gtc ctg ata tta ggt gga acc aca gca gca ggt gca ctt tta tat       1443
Gln Val Leu Ile Leu Gly Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr           
    460                 465                 470                           

gac aac tgg gtc cta aca gct gct cat gcc gtc tat gag caa aaa cat       1491
Asp Asn Trp Val Leu Thr Ala Ala His Ala Val Tyr Glu Gln Lys His           
475                 480                 485                 490           

gat gca tcc gcc ctg gac att cga atg ggc acc ctg aaa aga cta tca       1539
Asp Ala Ser Ala Leu Asp Ile Arg Met Gly Thr Leu Lys Arg Leu Ser           
                495                 500                 505               

cct cat tat aca caa gcc tgg tct gaa gct gtt ttt ata cat gaa ggt       1587
Pro His Tyr Thr Gln Ala Trp Ser Glu Ala Val Phe Ile His Glu Gly           
            510                 515                 520                   

tat act cat gat gct ggc ttt gac aat gac ata gca ctg att aaa ttg       1635
Tyr Thr His Asp Ala Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu           
        525                 530                 535                       

aat aac aaa gtt gta atc aat agc aac atc acg cct att tgt ctg cca       1683
Asn Asn Lys Val Val Ile Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro           
    540                 545                 550                           

aga aaa gaa gct gaa tcc ttt atg agg aca gat gac att gga act gca       1731
Arg Lys Glu Ala Glu Ser Phe Met Arg Thr Asp Asp Ile Gly Thr Ala           
555                 560                 565                 570           

tct gga tgg gga tta acc caa agg ggt ttt ctt gct aga aat cta atg       1779
Ser Gly Trp Gly Leu Thr Gln Arg Gly Phe Leu Ala Arg Asn Leu Met           
                575                 580                 585               

tat gtc gac ata ccg att gtt gac cat caa aaa tgt act gct gca tat       1827
Tyr Val Asp Ile Pro Ile Val Asp His Gln Lys Cys Thr Ala Ala Tyr           
            590                 595                 600                   

gaa aag cca ccc tat cca agg gga agt gta act gct aac atg ctt tgt       1875
Glu Lys Pro Pro Tyr Pro Arg Gly Ser Val Thr Ala Asn Met Leu Cys           
        605                 610                 615                       

gct ggc tta gaa agt ggg ggc aag gac agc tgc aga ggt gac agc gga       1923
Ala Gly Leu Glu Ser Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly           
    620                 625                 630                           

ggg gca ctg gtg ttt cta gat agt gaa aca gag agg tgg ttt gtg gga       1971
Gly Ala Leu Val Phe Leu Asp Ser Glu Thr Glu Arg Trp Phe Val Gly           
635                 640                 645                 650           

gga ata gtg tcc tgg ggt tcc atg aat tgt ggg gaa gca ggt cag tat       2019
Gly Ile Val Ser Trp Gly Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr           
                655                 660                 665               

gga gtc tac aca aaa gtt att aac tat att ccc tgg atc gag aac ata       2067
Gly Val Tyr Thr Lys Val Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile           
            670                 675                 680                   

att agt gat ttt taa cttgcgtgtc tgcagtcaag gattcttcat ttttagaaat       2122
Ile Ser Asp Phe                                                           
        685                                                               

gcctgtgaag accttggcag cgacgtggct cgagaagcat tcatcattac tgtggacatg     2182

gcagttgttg ctccacccaa aaaaacagac tccaggtgag gctgctgtca tttctccact     2242

tgccagttta attccagcct tacccattga ctcaagggga cataaaccac gagagtgaca     2302

gtcatctttg cccacccagt gtaatgtcac tgctcaaatt acatttcatt accttaaaaa     2362

gccagtctct tttcatactg gctgttggca tttctgtaaa ctgcctgtcc atgctctttg     2422

tttttaaact tgttcttatt gaaaaaaaaa aaaaaaaa                             2460


<210>  2
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg 
            180                 185                 190         


Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val Ile 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr Leu 
225                 230                 235                 240 


Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser Asn 
            260                 265                 270         


Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro Met 
    290                 295                 300                 


Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile Leu 
305                 310                 315                 320 


Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu Gln 
                325                 330                 335     


Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro Gly 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp Gly 
                405                 410                 415     


Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu Pro 
            420                 425                 430         


Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly Gly 
        435                 440                 445             


Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu Gly 
    450                 455                 460                 


Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu Thr 
465                 470                 475                 480 


Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu Asp 
                485                 490                 495     


Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln Ala 
            500                 505                 510         


Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala Gly 
        515                 520                 525             


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val Ile 
    530                 535                 540                 


Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu Ser 
545                 550                 555                 560 


Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu Thr 
                565                 570                 575     


Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro Ile 
            580                 585                 590         


Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr Pro 
        595                 600                 605             


Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser Gly 
    610                 615                 620                 


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
625                 630                 635                 640 


Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
                645                 650                 655     


Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val 
            660                 665                 670         


Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
        675                 680                 685     


<210>  3
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala 
1               5                   10                  15      


Ser Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp 
            20                  25                  30          


Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His 
        35                  40                  45              


Phe Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu 
    50                  55                  60                  


Ser Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr 
65                  70                  75                  80  


Asp Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser 
                85                  90                  95      


Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe 
            100                 105                 110         


Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln 
        115                 120                 125             


Val Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His 
    130                 135                 140                 


Leu Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg 
145                 150                 155                 160 


Asn Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln 
                165                 170                 175     


Arg Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys 
            180                 185                 190         


Leu Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val 
        195                 200                 205             


Ile Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr 
    210                 215                 220                 


Leu Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His 
225                 230                 235                 240 


Gly Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser 
                245                 250                 255     


Asn Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr 
            260                 265                 270         


Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro 
        275                 280                 285             


Met Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile 
    290                 295                 300                 


Leu Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu 
305                 310                 315                 320 


Gln Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp 
                325                 330                 335     


Gly Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly 
            340                 345                 350         


Pro Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro 
        355                 360                 365             


Gly Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr 
    370                 375                 380                 


Phe Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp 
385                 390                 395                 400 


Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu 
                405                 410                 415     


Pro Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly 
            420                 425                 430         


Gly Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu 
        435                 440                 445             


Gly Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu 
    450                 455                 460                 


Thr Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu 
465                 470                 475                 480 


Asp Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln 
                485                 490                 495     


Ala Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala 
            500                 505                 510         


Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val 
        515                 520                 525             


Ile Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu 
    530                 535                 540                 


Ser Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu 
545                 550                 555                 560 


Thr Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro 
                565                 570                 575     


Ile Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr 
            580                 585                 590         


Pro Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser 
        595                 600                 605             


Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe 
    610                 615                 620                 


Leu Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp 
625                 630                 635                 640 


Gly Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys 
                645                 650                 655     


Val Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
            660                 665                 670     


<210>  4
<211>  2091
<212>  DNA
<213>  Rat


<220>
<221>  CDS
<222>  (10)..(2067)

<400>  4
tggcacaca atg agg cta ctg atc gtc ctg ggt ctg ctt tgg agt ttg gtg       51
          Met Arg Leu Leu Ile Val Leu Gly Leu Leu Trp Ser Leu Val         
          1               5                   10                          

gcc aca ctt ttg ggc tcc aag tgg cct gag cct gta ttc ggg cgc ctg         99
Ala Thr Leu Leu Gly Ser Lys Trp Pro Glu Pro Val Phe Gly Arg Leu           
15                  20                  25                  30            

gtg tcc ctg gcc ttc cca gag aag tat ggc aac cat cag gat cga tcc        147
Val Ser Leu Ala Phe Pro Glu Lys Tyr Gly Asn His Gln Asp Arg Ser           
                35                  40                  45                

tgg acg ctg act gca ccc cct ggc ttc cgc ctg cgc ctc tac ttc acc        195
Trp Thr Leu Thr Ala Pro Pro Gly Phe Arg Leu Arg Leu Tyr Phe Thr           
            50                  55                  60                    

cac ttc aac ctg gaa ctc tct tac cgc tgc gag tat gac ttt gtc aag        243
His Phe Asn Leu Glu Leu Ser Tyr Arg Cys Glu Tyr Asp Phe Val Lys           
        65                  70                  75                        

ttg acc tca ggg acc aag gtg cta gcc acg ctg tgt ggg cag gag agt        291
Leu Thr Ser Gly Thr Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser           
    80                  85                  90                            

aca gat act gag cgg gca cct ggc aat gac acc ttc tac tca ctg ggt        339
Thr Asp Thr Glu Arg Ala Pro Gly Asn Asp Thr Phe Tyr Ser Leu Gly           
95                  100                 105                 110           

ccc agc cta aag gtc acc ttc cac tcc gac tac tcc aat gag aag cca        387
Pro Ser Leu Lys Val Thr Phe His Ser Asp Tyr Ser Asn Glu Lys Pro           
                115                 120                 125               

ttc aca gga ttt gag gcc ttc tat gca gcg gag gat gtg gat gaa tgc        435
Phe Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Val Asp Glu Cys           
            130                 135                 140                   

aga aca tcc ctg gga gac tca gtc cct tgt gac cat tat tgc cac aac        483
Arg Thr Ser Leu Gly Asp Ser Val Pro Cys Asp His Tyr Cys His Asn           
        145                 150                 155                       

tac ctg ggc ggc tac tac tgc tcc tgc cga gtg ggc tac att ctg cac        531
Tyr Leu Gly Gly Tyr Tyr Cys Ser Cys Arg Val Gly Tyr Ile Leu His           
    160                 165                 170                           

cag aac aag cat acc tgc tca gcc ctt tgt tca ggc cag gtg ttc act        579
Gln Asn Lys His Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr           
175                 180                 185                 190           

ggg agg tct ggc ttt ctc agt agc cct gag tac cca cag cca tac ccc        627
Gly Arg Ser Gly Phe Leu Ser Ser Pro Glu Tyr Pro Gln Pro Tyr Pro           
                195                 200                 205               

aaa ctc tcc agc tgc gcc tac aac atc cgc ctg gag gaa ggc ttc agt        675
Lys Leu Ser Ser Cys Ala Tyr Asn Ile Arg Leu Glu Glu Gly Phe Ser           
            210                 215                 220                   

atc acc ctg gac ttc gtg gag tcc ttt gat gtg gag atg cac cct gaa        723
Ile Thr Leu Asp Phe Val Glu Ser Phe Asp Val Glu Met His Pro Glu           
        225                 230                 235                       

gcc cag tgc ccc tac gac tcc ctc aag att caa aca gac aag agg gaa        771
Ala Gln Cys Pro Tyr Asp Ser Leu Lys Ile Gln Thr Asp Lys Arg Glu           
    240                 245                 250                           

tac ggc ccg ttt tgt ggg aag acg ctg ccc ccc agg att gaa act gac        819
Tyr Gly Pro Phe Cys Gly Lys Thr Leu Pro Pro Arg Ile Glu Thr Asp           
255                 260                 265                 270           

agc aac aag gtg acc att acc ttt acc acc gac gag tca ggg aac cac        867
Ser Asn Lys Val Thr Ile Thr Phe Thr Thr Asp Glu Ser Gly Asn His           
                275                 280                 285               

aca ggc tgg aag ata cac tac aca agc aca gca cag ccc tgc cct gat        915
Thr Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Asp           
            290                 295                 300                   

cca acg gcg cca cct aat ggt cac att tca cct gtg caa gcc acg tat        963
Pro Thr Ala Pro Pro Asn Gly His Ile Ser Pro Val Gln Ala Thr Tyr           
        305                 310                 315                       

gtc ctg aag gac agc ttt tct gtc ttc tgc aag act ggc ttc gag ctt       1011
Val Leu Lys Asp Ser Phe Ser Val Phe Cys Lys Thr Gly Phe Glu Leu           
    320                 325                 330                           

ctg caa ggt tct gtc ccc ctg aag tca ttc act gct gtc tgt cag aaa       1059
Leu Gln Gly Ser Val Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys           
335                 340                 345                 350           

gat gga tct tgg gac cgg ccg ata cca gag tgc agc att att gac tgt       1107
Asp Gly Ser Trp Asp Arg Pro Ile Pro Glu Cys Ser Ile Ile Asp Cys           
                355                 360                 365               

ggc cct ccc gat gac cta ccc aat ggc cac gtg gac tat atc aca ggc       1155
Gly Pro Pro Asp Asp Leu Pro Asn Gly His Val Asp Tyr Ile Thr Gly           
            370                 375                 380                   

cct gaa gtg acc acc tac aaa gct gtg att cag tac agc tgt gaa gag       1203
Pro Glu Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu           
        385                 390                 395                       

act ttc tac aca atg agc agc aat ggt aaa tat gtg tgt gag gct gat       1251
Thr Phe Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val Cys Glu Ala Asp           
    400                 405                 410                           

gga ttc tgg acg agc tcc aaa gga gaa aaa tcc ctc ccg gtt tgc aag       1299
Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Lys           
415                 420                 425                 430           

cct gtc tgt gga ctg tcc aca cac act tca gga ggc cgt ata att gga       1347
Pro Val Cys Gly Leu Ser Thr His Thr Ser Gly Gly Arg Ile Ile Gly           
                435                 440                 445               

gga cag cct gca aag cct ggt gac ttt cct tgg caa gtc ttg tta ctg       1395
Gly Gln Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Leu Leu           
            450                 455                 460                   

ggt gaa act aca gca gca ggt gct ctt ata cat gac gac tgg gtc cta       1443
Gly Glu Thr Thr Ala Ala Gly Ala Leu Ile His Asp Asp Trp Val Leu           
        465                 470                 475                       

aca gcg gct cat gct gta tat ggg aaa aca gag gcg atg tcc tcc ctg       1491
Thr Ala Ala His Ala Val Tyr Gly Lys Thr Glu Ala Met Ser Ser Leu           
    480                 485                 490                           

gac atc cgc atg ggc atc ctc aaa agg ctc tcc ctc att tac act caa       1539
Asp Ile Arg Met Gly Ile Leu Lys Arg Leu Ser Leu Ile Tyr Thr Gln           
495                 500                 505                 510           

gcc tgg cca gag gct gtc ttt atc cat gaa ggc tac act cac gga gct       1587
Ala Trp Pro Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Gly Ala           
                515                 520                 525               

ggt ttt gac aat gat ata gca ctg att aaa ctc aag aac aaa gtc aca       1635
Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Lys Asn Lys Val Thr           
            530                 535                 540                   

atc aac aga aac atc atg ccg att tgt cta cca aga aaa gaa gct gca       1683
Ile Asn Arg Asn Ile Met Pro Ile Cys Leu Pro Arg Lys Glu Ala Ala           
        545                 550                 555                       

tcc tta atg aaa aca gac ttc gtt gga act gtg gct ggc tgg ggg tta       1731
Ser Leu Met Lys Thr Asp Phe Val Gly Thr Val Ala Gly Trp Gly Leu           
    560                 565                 570                           

acc cag aag ggg ttt ctt gct aga aac cta atg ttt gtg gac ata cca       1779
Thr Gln Lys Gly Phe Leu Ala Arg Asn Leu Met Phe Val Asp Ile Pro           
575                 580                 585                 590           

att gtt gac cac caa aaa tgt gct act gcg tat aca aag cag ccc tac       1827
Ile Val Asp His Gln Lys Cys Ala Thr Ala Tyr Thr Lys Gln Pro Tyr           
                595                 600                 605               

cca gga gca aaa gtg act gtt aac atg ctc tgt gct ggc cta gac cgc       1875
Pro Gly Ala Lys Val Thr Val Asn Met Leu Cys Ala Gly Leu Asp Arg           
            610                 615                 620                   

ggt ggc aag gac agc tgc aga ggt gac agc gga ggg gca tta gtg ttt       1923
Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe           
        625                 630                 635                       

cta gac aat gaa aca cag aga tgg ttt gtg gga gga ata gtt tcc tgg       1971
Leu Asp Asn Glu Thr Gln Arg Trp Phe Val Gly Gly Ile Val Ser Trp           
    640                 645                 650                           

ggt tct att aac tgt ggg ggg tca gaa cag tat ggg gtc tac acg aaa       2019
Gly Ser Ile Asn Cys Gly Gly Ser Glu Gln Tyr Gly Val Tyr Thr Lys           
655                 660                 665                 670           

gtc acg aac tat att ccc tgg att gag aac ata ata aat aat ttc taa       2067
Val Thr Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Asn Asn Phe               
                675                 680                 685               

tttgcaaaaa aaaaaaaaaa aaaa                                            2091


<210>  5
<211>  685
<212>  PRT
<213>  Rat

<400>  5

Met Arg Leu Leu Ile Val Leu Gly Leu Leu Trp Ser Leu Val Ala Thr 
1               5                   10                  15      


Leu Leu Gly Ser Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Val Ser 
            20                  25                  30          


Leu Ala Phe Pro Glu Lys Tyr Gly Asn His Gln Asp Arg Ser Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Phe Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asn Leu Glu Leu Ser Tyr Arg Cys Glu Tyr Asp Phe Val Lys Leu Thr 
65                  70                  75                  80  


Ser Gly Thr Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Asn Asp Thr Phe Tyr Ser Leu Gly Pro Ser 
            100                 105                 110         


Leu Lys Val Thr Phe His Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Val Asp Glu Cys Arg Thr 
    130                 135                 140                 


Ser Leu Gly Asp Ser Val Pro Cys Asp His Tyr Cys His Asn Tyr Leu 
145                 150                 155                 160 


Gly Gly Tyr Tyr Cys Ser Cys Arg Val Gly Tyr Ile Leu His Gln Asn 
                165                 170                 175     


Lys His Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gly Arg 
            180                 185                 190         


Ser Gly Phe Leu Ser Ser Pro Glu Tyr Pro Gln Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Ala Tyr Asn Ile Arg Leu Glu Glu Gly Phe Ser Ile Thr 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Met His Pro Glu Ala Gln 
225                 230                 235                 240 


Cys Pro Tyr Asp Ser Leu Lys Ile Gln Thr Asp Lys Arg Glu Tyr Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro Pro Arg Ile Glu Thr Asp Ser Asn 
            260                 265                 270         


Lys Val Thr Ile Thr Phe Thr Thr Asp Glu Ser Gly Asn His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Asp Pro Thr 
    290                 295                 300                 


Ala Pro Pro Asn Gly His Ile Ser Pro Val Gln Ala Thr Tyr Val Leu 
305                 310                 315                 320 


Lys Asp Ser Phe Ser Val Phe Cys Lys Thr Gly Phe Glu Leu Leu Gln 
                325                 330                 335     


Gly Ser Val Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Ile Pro Glu Cys Ser Ile Ile Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Asn Gly His Val Asp Tyr Ile Thr Gly Pro Glu 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val Cys Glu Ala Asp Gly Phe 
                405                 410                 415     


Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Lys Pro Val 
            420                 425                 430         


Cys Gly Leu Ser Thr His Thr Ser Gly Gly Arg Ile Ile Gly Gly Gln 
        435                 440                 445             


Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Leu Leu Gly Glu 
    450                 455                 460                 


Thr Thr Ala Ala Gly Ala Leu Ile His Asp Asp Trp Val Leu Thr Ala 
465                 470                 475                 480 


Ala His Ala Val Tyr Gly Lys Thr Glu Ala Met Ser Ser Leu Asp Ile 
                485                 490                 495     


Arg Met Gly Ile Leu Lys Arg Leu Ser Leu Ile Tyr Thr Gln Ala Trp 
            500                 505                 510         


Pro Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Gly Ala Gly Phe 
        515                 520                 525             


Asp Asn Asp Ile Ala Leu Ile Lys Leu Lys Asn Lys Val Thr Ile Asn 
    530                 535                 540                 


Arg Asn Ile Met Pro Ile Cys Leu Pro Arg Lys Glu Ala Ala Ser Leu 
545                 550                 555                 560 


Met Lys Thr Asp Phe Val Gly Thr Val Ala Gly Trp Gly Leu Thr Gln 
                565                 570                 575     


Lys Gly Phe Leu Ala Arg Asn Leu Met Phe Val Asp Ile Pro Ile Val 
            580                 585                 590         


Asp His Gln Lys Cys Ala Thr Ala Tyr Thr Lys Gln Pro Tyr Pro Gly 
        595                 600                 605             


Ala Lys Val Thr Val Asn Met Leu Cys Ala Gly Leu Asp Arg Gly Gly 
    610                 615                 620                 


Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu Asp 
625                 630                 635                 640 


Asn Glu Thr Gln Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly Ser 
                645                 650                 655     


Ile Asn Cys Gly Gly Ser Glu Gln Tyr Gly Val Tyr Thr Lys Val Thr 
            660                 665                 670         


Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Asn Asn Phe 
        675                 680                 685 


<210>  6
<211>  670
<212>  PRT
<213>  Rat

<400>  6

Thr Leu Leu Gly Ser Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Val 
1               5                   10                  15      


Ser Leu Ala Phe Pro Glu Lys Tyr Gly Asn His Gln Asp Arg Ser Trp 
            20                  25                  30          


Thr Leu Thr Ala Pro Pro Gly Phe Arg Leu Arg Leu Tyr Phe Thr His 
        35                  40                  45              


Phe Asn Leu Glu Leu Ser Tyr Arg Cys Glu Tyr Asp Phe Val Lys Leu 
    50                  55                  60                  


Thr Ser Gly Thr Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr 
65                  70                  75                  80  


Asp Thr Glu Arg Ala Pro Gly Asn Asp Thr Phe Tyr Ser Leu Gly Pro 
                85                  90                  95      


Ser Leu Lys Val Thr Phe His Ser Asp Tyr Ser Asn Glu Lys Pro Phe 
            100                 105                 110         


Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Val Asp Glu Cys Arg 
        115                 120                 125             


Thr Ser Leu Gly Asp Ser Val Pro Cys Asp His Tyr Cys His Asn Tyr 
    130                 135                 140                 


Leu Gly Gly Tyr Tyr Cys Ser Cys Arg Val Gly Tyr Ile Leu His Gln 
145                 150                 155                 160 


Asn Lys His Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gly 
                165                 170                 175     


Arg Ser Gly Phe Leu Ser Ser Pro Glu Tyr Pro Gln Pro Tyr Pro Lys 
            180                 185                 190         


Leu Ser Ser Cys Ala Tyr Asn Ile Arg Leu Glu Glu Gly Phe Ser Ile 
        195                 200                 205             


Thr Leu Asp Phe Val Glu Ser Phe Asp Val Glu Met His Pro Glu Ala 
    210                 215                 220                 


Gln Cys Pro Tyr Asp Ser Leu Lys Ile Gln Thr Asp Lys Arg Glu Tyr 
225                 230                 235                 240 


Gly Pro Phe Cys Gly Lys Thr Leu Pro Pro Arg Ile Glu Thr Asp Ser 
                245                 250                 255     


Asn Lys Val Thr Ile Thr Phe Thr Thr Asp Glu Ser Gly Asn His Thr 
            260                 265                 270         


Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Asp Pro 
        275                 280                 285             


Thr Ala Pro Pro Asn Gly His Ile Ser Pro Val Gln Ala Thr Tyr Val 
    290                 295                 300                 


Leu Lys Asp Ser Phe Ser Val Phe Cys Lys Thr Gly Phe Glu Leu Leu 
305                 310                 315                 320 


Gln Gly Ser Val Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp 
                325                 330                 335     


Gly Ser Trp Asp Arg Pro Ile Pro Glu Cys Ser Ile Ile Asp Cys Gly 
            340                 345                 350         


Pro Pro Asp Asp Leu Pro Asn Gly His Val Asp Tyr Ile Thr Gly Pro 
        355                 360                 365             


Glu Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr 
    370                 375                 380                 


Phe Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val Cys Glu Ala Asp Gly 
385                 390                 395                 400 


Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Lys Pro 
                405                 410                 415     


Val Cys Gly Leu Ser Thr His Thr Ser Gly Gly Arg Ile Ile Gly Gly 
            420                 425                 430         


Gln Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Leu Leu Gly 
        435                 440                 445             


Glu Thr Thr Ala Ala Gly Ala Leu Ile His Asp Asp Trp Val Leu Thr 
    450                 455                 460                 


Ala Ala His Ala Val Tyr Gly Lys Thr Glu Ala Met Ser Ser Leu Asp 
465                 470                 475                 480 


Ile Arg Met Gly Ile Leu Lys Arg Leu Ser Leu Ile Tyr Thr Gln Ala 
                485                 490                 495     


Trp Pro Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Gly Ala Gly 
            500                 505                 510         


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Lys Asn Lys Val Thr Ile 
        515                 520                 525             


Asn Arg Asn Ile Met Pro Ile Cys Leu Pro Arg Lys Glu Ala Ala Ser 
    530                 535                 540                 


Leu Met Lys Thr Asp Phe Val Gly Thr Val Ala Gly Trp Gly Leu Thr 
545                 550                 555                 560 


Gln Lys Gly Phe Leu Ala Arg Asn Leu Met Phe Val Asp Ile Pro Ile 
                565                 570                 575     


Val Asp His Gln Lys Cys Ala Thr Ala Tyr Thr Lys Gln Pro Tyr Pro 
            580                 585                 590         


Gly Ala Lys Val Thr Val Asn Met Leu Cys Ala Gly Leu Asp Arg Gly 
        595                 600                 605             


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
    610                 615                 620                 


Asp Asn Glu Thr Gln Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
625                 630                 635                 640 


Ser Ile Asn Cys Gly Gly Ser Glu Gln Tyr Gly Val Tyr Thr Lys Val 
                645                 650                 655     


Thr Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Asn Asn Phe 
            660                 665                 670 


<210>  7
<211>  136
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  7

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala 
    130                 135     


<210>  8
<211>  181
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  8

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser 
            180     


<210>  9
<211>  277
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  9

Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala 
1               5                   10                  15      


Ser Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp 
            20                  25                  30          


Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His 
        35                  40                  45              


Phe Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu 
    50                  55                  60                  


Ser Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr 
65                  70                  75                  80  


Asp Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser 
                85                  90                  95      


Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe 
            100                 105                 110         


Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln 
        115                 120                 125             


Val Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His 
    130                 135                 140                 


Leu Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg 
145                 150                 155                 160 


Asn Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln 
                165                 170                 175     


Arg Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys 
            180                 185                 190         


Leu Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val 
        195                 200                 205             


Ile Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr 
    210                 215                 220                 


Leu Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His 
225                 230                 235                 240 


Gly Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser 
                245                 250                 255     


Asn Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr 
            260                 265                 270         


Gly Trp Lys Ile His 
        275         


<210>  10
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  10

Glu Asp Ile Asp Glu Cys Gln Val Ala Pro Gly Glu Ala Pro Thr Cys 
1               5                   10                  15      


Asp His His Cys His Asn His Leu Gly Gly Phe Tyr Cys Ser Cys Arg 
            20                  25                  30          


Ala Gly Tyr Val Leu His Arg Asn Lys 
        35                  40      


<210>  11
<211>  394
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  11

Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro Met Ala Pro Pro Asn 
1               5                   10                  15      


Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile Leu Lys Asp Ser Phe 
            20                  25                  30          


Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu Gln Gly His Leu Pro 
        35                  40                  45              


Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly Ser Trp Asp Arg 
    50                  55                  60                  


Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly Pro Pro Asp Asp Leu 
65                  70                  75                  80  


Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro Gly Val Thr Thr Tyr 
                85                  90                  95      


Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe Tyr Thr Met Lys 
            100                 105                 110         


Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp Gly Phe Trp Thr Ser 
        115                 120                 125             


Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu Pro Val Cys Gly Leu 
    130                 135                 140                 


Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly Gly Gln Lys Ala Lys 
145                 150                 155                 160 


Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu Gly Gly Thr Thr Ala 
                165                 170                 175     


Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu Thr Ala Ala His Ala 
            180                 185                 190         


Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu Asp Ile Arg Met Gly 
        195                 200                 205             


Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln Ala Trp Ser Glu Ala 
    210                 215                 220                 


Val Phe Ile His Glu Gly Tyr Thr His Asp Ala Gly Phe Asp Asn Asp 
225                 230                 235                 240 


Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val Ile Asn Ser Asn Ile 
                245                 250                 255     


Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu Ser Phe Met Arg Thr 
            260                 265                 270         


Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu Thr Gln Arg Gly Phe 
        275                 280                 285             


Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro Ile Val Asp His Gln 
    290                 295                 300                 


Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr Pro Arg Gly Ser Val 
305                 310                 315                 320 


Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser Gly Gly Lys Asp Ser 
                325                 330                 335     


Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu Asp Ser Glu Thr 
            340                 345                 350         


Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly Ser Met Asn Cys 
        355                 360                 365             


Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val Ile Asn Tyr Ile 
    370                 375                 380                 


Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
385                 390                 


<210>  12
<211>  152
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  12

Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro Met Ala Pro Pro Asn 
1               5                   10                  15      


Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile Leu Lys Asp Ser Phe 
            20                  25                  30          


Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu Gln Gly His Leu Pro 
        35                  40                  45              


Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly Ser Trp Asp Arg 
    50                  55                  60                  


Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly Pro Pro Asp Asp Leu 
65                  70                  75                  80  


Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro Gly Val Thr Thr Tyr 
                85                  90                  95      


Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe Tyr Thr Met Lys 
            100                 105                 110         


Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp Gly Phe Trp Thr Ser 
        115                 120                 125             


Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu Pro Val Cys Gly Leu 
    130                 135                 140                 


Ser Ala Arg Thr Thr Gly Gly Arg 
145                 150         


<210>  13
<211>  70
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  13

Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro Met Ala Pro Pro Asn 
1               5                   10                  15      


Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile Leu Lys Asp Ser Phe 
            20                  25                  30          


Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu Gln Gly His Leu Pro 
        35                  40                  45              


Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly Ser Trp Asp Arg 
    50                  55                  60                  


Pro Met Pro Ala Cys Ser 
65                  70  


<210>  14
<211>  324
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  14

Ile Val Asp Cys Gly Pro Pro Asp Asp Leu Pro Ser Gly Arg Val Glu 
1               5                   10                  15      


Tyr Ile Thr Gly Pro Gly Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr 
            20                  25                  30          


Ser Cys Glu Glu Thr Phe Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr 
        35                  40                  45              


Val Cys Glu Ala Asp Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser 
    50                  55                  60                  


Leu Pro Val Cys Glu Pro Val Cys Gly Leu Ser Ala Arg Thr Thr Gly 
65                  70                  75                  80  


Gly Arg Ile Tyr Gly Gly Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp 
                85                  90                  95      


Gln Val Leu Ile Leu Gly Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr 
            100                 105                 110         


Asp Asn Trp Val Leu Thr Ala Ala His Ala Val Tyr Glu Gln Lys His 
        115                 120                 125             


Asp Ala Ser Ala Leu Asp Ile Arg Met Gly Thr Leu Lys Arg Leu Ser 
    130                 135                 140                 


Pro His Tyr Thr Gln Ala Trp Ser Glu Ala Val Phe Ile His Glu Gly 
145                 150                 155                 160 


Tyr Thr His Asp Ala Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu 
                165                 170                 175     


Asn Asn Lys Val Val Ile Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro 
            180                 185                 190         


Arg Lys Glu Ala Glu Ser Phe Met Arg Thr Asp Asp Ile Gly Thr Ala 
        195                 200                 205             


Ser Gly Trp Gly Leu Thr Gln Arg Gly Phe Leu Ala Arg Asn Leu Met 
    210                 215                 220                 


Tyr Val Asp Ile Pro Ile Val Asp His Gln Lys Cys Thr Ala Ala Tyr 
225                 230                 235                 240 


Glu Lys Pro Pro Tyr Pro Arg Gly Ser Val Thr Ala Asn Met Leu Cys 
                245                 250                 255     


Ala Gly Leu Glu Ser Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly 
            260                 265                 270         


Gly Ala Leu Val Phe Leu Asp Ser Glu Thr Glu Arg Trp Phe Val Gly 
        275                 280                 285             


Gly Ile Val Ser Trp Gly Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr 
    290                 295                 300                 


Gly Val Tyr Thr Lys Val Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile 
305                 310                 315                 320 


Ile Ser Asp Phe 
                


<210>  15
<211>  82
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  15

Ile Val Asp Cys Gly Pro Pro Asp Asp Leu Pro Ser Gly Arg Val Glu 
1               5                   10                  15      


Tyr Ile Thr Gly Pro Gly Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr 
            20                  25                  30          


Ser Cys Glu Glu Thr Phe Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr 
        35                  40                  45              


Val Cys Glu Ala Asp Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser 
    50                  55                  60                  


Leu Pro Val Cys Glu Pro Val Cys Gly Leu Ser Ala Arg Thr Thr Gly 
65                  70                  75                  80  


Gly Arg 
        


<210>  16
<211>  242
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  16

Ile Tyr Gly Gly Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val 
1               5                   10                  15      


Leu Ile Leu Gly Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn 
            20                  25                  30          


Trp Val Leu Thr Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala 
        35                  40                  45              


Ser Ala Leu Asp Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His 
    50                  55                  60                  


Tyr Thr Gln Ala Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr 
65                  70                  75                  80  


His Asp Ala Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn 
                85                  90                  95      


Lys Val Val Ile Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys 
            100                 105                 110         


Glu Ala Glu Ser Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly 
        115                 120                 125             


Trp Gly Leu Thr Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val 
    130                 135                 140                 


Asp Ile Pro Ile Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys 
145                 150                 155                 160 


Pro Pro Tyr Pro Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly 
                165                 170                 175     


Leu Glu Ser Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala 
            180                 185                 190         


Leu Val Phe Leu Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile 
        195                 200                 205             


Val Ser Trp Gly Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val 
    210                 215                 220                 


Tyr Thr Lys Val Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser 
225                 230                 235                 240 


Asp Phe 
        


<210>  17
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  17

Gly Lys Asp Ser Cys Arg Gly Asp Ala Gly Gly Ala Leu Val Phe Leu 
1               5                   10                  15      


<210>  18
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  18

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Gly 
            20                  25                  30          


Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr Arg Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Ala Gly Gly Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  19
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  19
caggtcacct tgaaggagtc tggtcctgtg ctggtgaaac ccacagagac cctcacgctg       60

acctgcaccg tctctgggtt ctcactcagc aggggtaaaa tgggtgtgag ctggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacacattt tttcgagtga cgaaaaatcc      180

tacaggacat cgctgaagag caggctcacc atctccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca cgtattactg tgcacggata      300

cgacgtggag gaattgacta ctggggccag ggaaccctgg tcactgtctc ctca            354


<210>  20
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  20

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Gly 
            20                  25                  30          


Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr Arg Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Arg Gly Gly Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  21
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  21

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Thr 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Pro Phe Gly Val Pro Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  22
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  22

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Phe Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly His Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val 
                85                  90                  95      


Phe Gly Thr Gly Thr Lys Val Thr Val Leu Ala 
            100                 105         


<210>  23
<211>  318
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (246)..(246)
<223>  n is a, c, g, or t

<400>  23
cagccagtgc tgactcagcc cccctcactg tccgtgtccc caggacagac agccagcatc       60

acctgctctg gagagaaatt gggggataaa tatgcttact ggtatcagca gaagccaggc      120

cagtcccctg tgttggtcat gtatcaagat aaacagcggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgangctg actattactg tcaggcgtgg gacagcagca ctgcggtatt cggcggaggg      300

accaagctga ccgtccta                                                    318


<210>  24
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  24

Gln Pro Val Leu Thr Gln Pro Pro Ser Leu Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Glu Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Met Tyr 
        35                  40                  45              


Gln Asp Lys Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  25
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  25

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Val Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Thr Thr Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ala Gly 
            100                 105                 110         


Ser Glu Gln Lys Leu Ile Ser Glu 
        115                 120 


<210>  26
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  26
tcctatgagc tgatacagcc accctcggtg tcagtggccc caggacagac ggccaccatt       60

acctgtgcgg gagacaacct tgggaagaaa cgtgtgcact ggtaccagca gaggccaggc      120

caggcccctg tgttggtcat ctatgatgat agcgaccggc cctcagggat ccctgaccga      180

ttctctgcct ccaactctgg gaacacggcc accctgacca tcactagggg cgaagccggg      240

gatgaggccg actattattg tcaggtgtgg gacattgcta ctgatcatgt ggtcttcggc      300

ggagggacca agctcaccgt ccta                                             324


<210>  27
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  27

Ser Tyr Glu Leu Ile Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Ala Gly Asp Asn Leu Gly Lys Lys Arg Val 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Thr Arg Gly Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ile Ala Thr Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ala Gly 
            100                 105                 110         


Ser Glu Gln Lys Leu Ile Ser Glu 
        115                 120 


<210>  28
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  28

Arg Gly Lys Met Gly 
1               5   


<210>  29
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  29

Ser Thr Ser Ala Ala 
1               5   


<210>  30
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  30

Gly Phe Ser Leu Ser Arg Gly 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  31

Gly Asp Ser Val Ser Ser Thr 
1               5           


<210>  32
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  32

Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr Arg Thr Ser Leu 
1               5                   10                  15      


<210>  33
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  33

Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val 
1               5                   10                  15      


<210>  34
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  34

His Ile Phe Ser Ser 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  35

Arg Thr Tyr Tyr Arg 
1               5   


<210>  36
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  36

Tyr Tyr Cys Ala Arg Ile Arg Ala 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  37

Tyr Tyr Cys Ala Arg Ile Arg Arg 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  38

Ala Val Tyr Tyr Cys Ala Arg Asp 
1               5               


<210>  39
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  39

Tyr Tyr Cys Ala Arg Ile Arg 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  40

Ala Val Tyr Tyr Cys Ala Arg 
1               5           


<210>  41
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  41

Gly Asp Lys Leu Gly Asp Lys Phe Ala Tyr Trp 
1               5                   10      


<210>  42
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  42

Gly Glu Lys Leu Gly Asp Lys Tyr Ala Tyr Trp 
1               5                   10      


<210>  43
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  43

Gly Asn Asn Ile Gly Ser Lys Asn Val His Trp 
1               5                   10      


<210>  44
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  44

Gly Asp Asn Leu Gly Lys Lys Arg Val His Trp 
1               5                   10      


<210>  45
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  45

Ala Gly Asp Asn Leu Gly Lys Lys Arg Val His Trp Tyr Gln Gln Arg 
1               5                   10                  15      


<210>  46
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  46

Asp Asn Lys Arg Pro Ser Gly 
1               5           


<210>  47
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  47

Asp Lys Gln Arg Pro Ser Gly 
1               5           


<210>  48
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  48

Asp Lys Gln Arg Pro Ser Gly Ile Pro Glu Arg 
1               5                   10      


<210>  49
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  49

Asp Ser Asp Arg Pro Ser Gly 
1               5           


<210>  50
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  50

Asp Ser Asp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala 
1               5                   10                  


<210>  51
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  51

Ala Trp Asp Ser Ser Thr Ala Val Phe 
1               5                   


<210>  52
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  52

Ala Trp Asp Ser Ser Thr Ala Val Phe Gly Gly Gly Thr Lys Leu Thr 
1               5                   10                  15      


<210>  53
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  53

Val Trp Asp Thr Thr Thr Asp His Val 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  54

Val Trp Asp Ile Ala Thr Asp His Val 
1               5                   


<210>  55
<211>  268
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  55

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Gly 
            20                  25                  30          


Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr Arg Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Ala Gly Gly Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys 
        115                 120                 125             


Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Gln Pro Val Leu Thr 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr 
145                 150                 155                 160 


Cys Ser Gly Asp Lys Leu Gly Asp Lys Phe Ala Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly His Ser Pro Val Leu Val Ile Tyr Gln Asp Asn Lys Arg 
            180                 185                 190         


Pro Ser Gly Ile Pro Gly Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
        195                 200                 205             


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val Phe Gly Thr Gly Thr 
225                 230                 235                 240 


Lys Val Thr Val Leu Ala Ala Ala Gly Ser Glu Gln Lys Leu Ile Ser 
                245                 250                 255     


Glu Glu Asp Leu Asn Ser His His His His His His 
            260                 265             


<210>  56
<211>  271
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  56

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Ala 
            20                  25                  30          


Arg Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Ser Asn Asp Glu Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Ala Ile Leu Thr Ala Gly Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser 
        115                 120                 125             


Ala Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr 
    130                 135                 140                 


Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ser Pro Gly Gln Thr Ala 
145                 150                 155                 160 


Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Arg Ser Pro Val Leu Val Ile Tyr Arg Asp 
            180                 185                 190         


Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Tyr 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Val Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Gly Ser Gly Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Thr Val Leu Ala Ala Ala Gly Ser Glu Gln Lys 
                245                 250                 255     


Leu Ile Ser Glu Glu Asp Leu Asn Ser His His His His His His 
            260                 265                 270     


<210>  57
<211>  272
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  57

Gln Ile Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Ala 
            20                  25                  30          


Arg Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Ser Asn Asp Glu Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Ser Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Arg Tyr Ser Ser Ser Leu Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Arg Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala 
        115                 120                 125             


Ser Ala Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser 
    130                 135                 140                 


Tyr Glu Leu Ile Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr 
145                 150                 155                 160 


Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Arg Ser Pro Val Leu Val Ile Tyr Arg 
            180                 185                 190         


Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
        195                 200                 205             


Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ala Gly Ser Glu Gln 
                245                 250                 255     


Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser His His His His His His 
            260                 265                 270         


<210>  58
<211>  273
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  58

Glu Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Lys 
            20                  25                  30          


Arg Ala Ala Trp Asp Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Phe Asn Asp Tyr Ala 
    50                  55                  60                  


Ile Ser Val Lys Ser Arg Ile Thr Ile Asn Ala Asp Thr Ser Arg Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Val Lys Ser Asn Ser Gly Thr Gly Ala Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala 
        115                 120                 125             


Ser Ala Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Gln 
    130                 135                 140                 


Pro Gly Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr 
145                 150                 155                 160 


Ala Arg Ile Thr Cys Ser Arg Asp Lys Leu Gly Asp Lys Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Val Val Met Tyr Lys 
            180                 185                 190         


Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
        195                 200                 205             


Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Gly Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ala Gly Ser Glu 
                245                 250                 255     


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser His His His His His 
            260                 265                 270         


His 
    


<210>  59
<211>  273
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  59

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Thr 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Pro Phe Gly Val Pro Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser 
        115                 120                 125             


Ala Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr 
    130                 135                 140                 


Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala 
145                 150                 155                 160 


Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val His Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp 
            180                 185                 190         


Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Val Ser Arg Val Glu Ala Gly Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Thr Thr Asp His Val Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ala Gly Ser Glu 
                245                 250                 255     


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser His His His His His 
            260                 265                 270         


His 
    


<210>  60
<211>  273
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  60

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Pro Phe Gly Val Pro Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser 
        115                 120                 125             


Ala Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr 
    130                 135                 140                 


Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala 
145                 150                 155                 160 


Arg Val Thr Cys Gly Gly Asn Asn Ile Arg Ser Lys Asn Val His Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp 
            180                 185                 190         


Thr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Val Ser Arg Val Glu Ala Gly Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Thr Thr Asp His Val Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ala Gly Ser Glu 
                245                 250                 255     


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser His His His His His 
            260                 265                 270         


His 
    


<210>  61
<211>  273
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  61

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Pro Phe Gly Val Pro Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser 
        115                 120                 125             


Ala Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr 
    130                 135                 140                 


Glu Leu Thr Gln Leu Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala 
145                 150                 155                 160 


Arg Val Thr Cys Gly Gly Asn Asn Ile Arg Ser Lys Asn Val His Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp 
            180                 185                 190         


Thr Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Val Ser Arg Val Glu Ala Gly Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Thr Thr Asp His Val Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Thr Val Leu Ala Ala Ala Gly Ser Glu 
                245                 250                 255     


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser His His His His His 
            260                 265                 270         


His 
    


<210>  62
<211>  984
<212>  DNA
<213>  Homo sapiens

<400>  62
gcctccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctcgggaa atga                                             984


<210>  63
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  63

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  64
<211>  984
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  64
gcctccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc accatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctctcgggaa atga                                             984


<210>  65
<211>  327
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  65

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  66
<211>  262
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  66

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Thr 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Pro Phe Gly Val Pro Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser 
        115                 120                 125             


Ala Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr 
    130                 135                 140                 


Glu Leu Ile Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala 
145                 150                 155                 160 


Thr Ile Thr Cys Ala Gly Asp Asn Leu Gly Lys Lys Arg Val His Trp 
                165                 170                 175     


Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Asp 
            180                 185                 190         


Ser Asp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser Asn Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Ile Thr Arg Gly Glu Ala Gly Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ile Ala Thr Asp His Val Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ala Gly Ser Glu 
                245                 250                 255     


Gln Lys Leu Ile Ser Glu 
            260         


<210>  67
<211>  245
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  67

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Gly 
            20                  25                  30          


Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr Arg Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Ala Gly Gly Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys 
        115                 120                 125             


Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Gln Pro Val Leu Thr 
    130                 135                 140                 


Gln Pro Pro Ser Leu Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr 
145                 150                 155                 160 


Cys Ser Gly Glu Lys Leu Gly Asp Lys Tyr Ala Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ser Pro Val Leu Val Met Tyr Gln Asp Lys Gln Arg 
            180                 185                 190         


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
        195                 200                 205             


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu 
                245 


<210>  68
<211>  245
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  68

Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Gly 
            20                  25                  30          


Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr Arg Thr Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Arg Gly Gly Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys 
        115                 120                 125             


Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Gln Pro Val Leu Thr 
    130                 135                 140                 


Gln Pro Pro Ser Leu Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr 
145                 150                 155                 160 


Cys Ser Gly Glu Lys Leu Gly Asp Lys Tyr Ala Tyr Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ser Pro Val Leu Val Met Tyr Gln Asp Lys Gln Arg 
            180                 185                 190         


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
        195                 200                 205             


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu 
                245 


<210>  69
<211>  981
<212>  DNA
<213>  Homo sapiens

<400>  69
gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      300

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      360

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      420

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      480

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      540

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc      600

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg      660

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      720

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtagagtgg      780

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac      840

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      900

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc      960

tccctgtctc ccgggaaatg a                                                981


<210>  70
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  70

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  71
<211>  702
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  71
atgatgtcct ttgtctctct gctcctggtt ggcatcctat tccatgccac ccaggcctcc       60

tatgagctga tacagccacc ctcggtgtca gtggccccag gacagacggc caccattacc      120

tgtgcgggag acaaccttgg gaagaaacgt gtgcactggt accagcagag gccaggccag      180

gcccctgtgt tggtcatcta tgatgatagc gaccggccct cagggatccc tgaccgattc      240

tctgcctcca actctgggaa cacggccacc ctgaccatca ctaggggcga agccggggat      300

gaggccgact attattgtca ggtgtgggac attgctactg atcatgtggt cttcggcgga      360

gggaccaagc tcaccgtcct aggccagcct aaggcggcgc cctcggtcac cctgttcccg      420

ccctcctctg aggagcttca agccaacaag gccacactgg tgtgtctcat aagtgacttc      480

tacccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg      540

gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctatctgagc      600

ctgacgcctg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg      660

agcaccgtgg agaagacagt ggcccctaca gaatgttcat ag                         702


<210>  72
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  72

Met Met Ser Phe Val Ser Leu Leu Leu Val Gly Ile Leu Phe His Ala 
1               5                   10                  15      


Thr Gln Ala Ser Tyr Glu Leu Ile Gln Pro Pro Ser Val Ser Val Ala 
            20                  25                  30          


Pro Gly Gln Thr Ala Thr Ile Thr Cys Ala Gly Asp Asn Leu Gly Lys 
        35                  40                  45              


Lys Arg Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu 
    50                  55                  60                  


Val Ile Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Asp Arg Phe 
65                  70                  75                  80  


Ser Ala Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Thr Arg Gly 
                85                  90                  95      


Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ile Ala 
            100                 105                 110         


Thr Asp His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
        115                 120                 125             


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
145                 150                 155                 160 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
                165                 170                 175     


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
            180                 185                 190         


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
        195                 200                 205             


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
    210                 215                 220                 


Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230             


<210>  73
<211>  1401
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  73
atgatgtcct ttgtctctct gctcctggtt ggcatcctat tccatgccac ccaggcccag       60

gtacagctgc agcagtcagg tccaggactg gtgaagccct cgcagaccct ctcactcacc      120

tgtgccatct ccggggacag tgtctctagc accagtgctg cttggaactg gatcaggcag      180

tccccatcga gaggccttga gtggctggga aggacatact acaggtccaa gtggtataat      240

gattatgcag tatctgtgaa aagtcgaata accatcaacc cagacacatc caagaaccag      300

ttctccctgc agctgaactc tgtgactccc gaggacacgg ctgtgtatta ctgtgcaaga      360

gatcctttcg gggtaccttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag      480

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc      720

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc      780

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc      840

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc      900

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt      960

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc     1020

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg     1080

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac     1140

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtagagtgg     1200

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac     1260

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1320

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1380

tccctgtctc ccgggaaatg a                                               1401


<210>  74
<211>  466
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  74

Met Met Ser Phe Val Ser Leu Leu Leu Val Gly Ile Leu Phe His Ala 
1               5                   10                  15      


Thr Gln Ala Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val 
        35                  40                  45              


Ser Ser Thr Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg 
    50                  55                  60                  


Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
65                  70                  75                  80  


Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Phe Gly Val Pro Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  75
<211>  1404
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  75
atgatgtcct ttgtctctct gctcctggtt ggcatcctat tccatgccac ccaggcccag       60

gtacagctgc agcagtcagg tccaggactg gtgaagccct cgcagaccct ctcactcacc      120

tgtgccatct ccggggacag tgtctctagc accagtgctg cttggaactg gatcaggcag      180

tccccatcga gaggccttga gtggctggga aggacatact acaggtccaa gtggtataat      240

gattatgcag tatctgtgaa aagtcgaata accatcaacc cagacacatc caagaaccag      300

ttctccctgc agctgaactc tgtgactccc gaggacacgg ctgtgtatta ctgtgcaaga      360

gatcctttcg gggtaccttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

gcctccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      480

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      720

aaatatggtc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      780

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      840

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     1320

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc     1380

ctctccctgt ctctcgggaa atga                                            1404


<210>  76
<211>  467
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  76

Met Met Ser Phe Val Ser Leu Leu Leu Val Gly Ile Leu Phe His Ala 
1               5                   10                  15      


Thr Gln Ala Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val 
        35                  40                  45              


Ser Ser Thr Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg 
    50                  55                  60                  


Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
65                  70                  75                  80  


Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Phe Gly Val Pro Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
225                 230                 235                 240 


Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Leu Gly Lys 
465         


<210>  77
<211>  1404
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  77
atgatgtcct ttgtctctct gctcctggtt ggcatcctat tccatgccac ccaggcccag       60

gtacagctgc agcagtcagg tccaggactg gtgaagccct cgcagaccct ctcactcacc      120

tgtgccatct ccggggacag tgtctctagc accagtgctg cttggaactg gatcaggcag      180

tccccatcga gaggccttga gtggctggga aggacatact acaggtccaa gtggtataat      240

gattatgcag tatctgtgaa aagtcgaata accatcaacc cagacacatc caagaaccag      300

ttctccctgc agctgaactc tgtgactccc gaggacacgg ctgtgtatta ctgtgcaaga      360

gatcctttcg gggtaccttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

gcctccacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      480

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      720

aaatatggtc ccccatgccc accatgccca gcacctgagt tcctgggggg accatcagtc      780

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      840

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     1320

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc     1380

ctctccctgt ctctcgggaa atga                                            1404


<210>  78
<211>  467
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  78

Met Met Ser Phe Val Ser Leu Leu Leu Val Gly Ile Leu Phe His Ala 
1               5                   10                  15      


Thr Gln Ala Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val 
        35                  40                  45              


Ser Ser Thr Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg 
    50                  55                  60                  


Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
65                  70                  75                  80  


Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Phe Gly Val Pro Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
225                 230                 235                 240 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Leu Gly Lys 
465         


<210>  79
<211>  696
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (303)..(303)
<223>  n is a, c, g, or t

<400>  79
atgatgtcct ttgtctctct gctcctggtt ggcatcctat tccatgccac ccaggcccag       60

ccagtgctga ctcagccccc ctcactgtcc gtgtccccag gacagacagc cagcatcacc      120

tgctctggag agaaattggg ggataaatat gcttactggt atcagcagaa gccaggccag      180

tcccctgtgt tggtcatgta tcaagataaa cagcggccct cagggatccc tgagcgattc      240

tctggctcca actctgggaa cacagccact ctgaccatca gcgggaccca ggctatggat      300

gangctgact attactgtca ggcgtgggac agcagcactg cggtattcgg cggagggacc      360

aagctgaccg tcctaggcca gcctaaggcg gcgccctcgg tcaccctgtt cccgccctcc      420

tctgaggagc ttcaagccaa caaggccaca ctggtgtgtc tcataagtga cttctacccg      480

ggagccgtga cagtggcctg gaaggcagat agcagccccg tcaaggcggg agtggagacc      540

accacaccct ccaaacaaag caacaacaag tacgcggcca gcagctatct gagcctgacg      600

cctgagcagt ggaagtccca cagaagctac agctgccagg tcacgcatga agggagcacc      660

gtggagaaga cagtggcccc tacagaatgt tcatag                                696


<210>  80
<211>  231
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  80

Met Met Ser Phe Val Ser Leu Leu Leu Val Gly Ile Leu Phe His Ala 
1               5                   10                  15      


Thr Gln Ala Gln Pro Val Leu Thr Gln Pro Pro Ser Leu Ser Val Ser 
            20                  25                  30          


Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly Glu Lys Leu Gly Asp 
        35                  40                  45              


Lys Tyr Ala Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu 
    50                  55                  60                  


Val Met Tyr Gln Asp Lys Gln Arg Pro Ser Gly Ile Pro Glu Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr 
                85                  90                  95      


Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser 
            100                 105                 110         


Thr Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
        115                 120                 125             


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
    130                 135                 140                 


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
145                 150                 155                 160 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
                165                 170                 175     


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
            180                 185                 190         


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
        195                 200                 205             


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
    210                 215                 220                 


Val Ala Pro Thr Glu Cys Ser 
225                 230     


<210>  81
<211>  1392
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  81
atgatgtcct ttgtctctct gctcctggtt ggcatcctat tccatgccac ccaggcccag       60

gtcaccttga aggagtctgg tcctgtgctg gtgaaaccca cagagaccct cacgctgacc      120

tgcaccgtct ctgggttctc actcagcagg ggtaaaatgg gtgtgagctg gatccgtcag      180

cccccaggga aggccctgga gtggcttgca cacatttttt cgagtgacga aaaatcctac      240

aggacatcgc tgaagagcag gctcaccatc tccaaggaca cctccaaaaa ccaggtggtc      300

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtgc acggatacga      360

cgtggaggaa ttgactactg gggccaggga accctggtca ctgtctcctc agcctccacc      420

aagggcccat cggtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgctctga ccagcggcgt gcacaccttc ccagctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcaacttcg gcacccagac ctacacctgc      660

aacgtagatc acaagcccag caacaccaag gtggacaaga cagttgagcg caaatgttgt      720

gtcgagtgcc caccgtgccc agcaccacct gtggcaggac cgtcagtctt cctcttcccc      780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg      840

gacgtgagcc acgaagaccc cgaggtccag ttcaactggt acgtggacgg cgtggaggtg      900

cataatgcca agacaaagcc acgggaggag cagttcaaca gcacgttccg tgtggtcagc      960

gtcctcaccg ttgtgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc     1020

aacaaaggcc tcccagcccc catcgagaaa accatctcca aaaccaaagg gcagccccga     1080

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1140

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtagagtg ggagagcaat     1200

gggcagccgg agaacaacta caagaccaca cctcccatgc tggactccga cggctccttc     1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1380

cccgggaaat ga                                                         1392


<210>  82
<211>  463
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  82

Met Met Ser Phe Val Ser Leu Leu Leu Val Gly Ile Leu Phe His Ala 
1               5                   10                  15      


Thr Gln Ala Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys 
            20                  25                  30          


Pro Thr Glu Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Arg Gly Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr 
65                  70                  75                  80  


Arg Thr Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Arg Arg Gly Gly Ile Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  83
<211>  1395
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  83
atgatgtcct ttgtctctct gctcctggtt ggcatcctat tccatgccac ccaggcccag       60

gtcaccttga aggagtctgg tcctgtgctg gtgaaaccca cagagaccct cacgctgacc      120

tgcaccgtct ctgggttctc actcagcagg ggtaaaatgg gtgtgagctg gatccgtcag      180

cccccaggga aggccctgga gtggcttgca cacatttttt cgagtgacga aaaatcctac      240

aggacatcgc tgaagagcag gctcaccatc tccaaggaca cctccaaaaa ccaggtggtc      300

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtgc acggatacga      360

cgtggaggaa ttgactactg gggccaggga accctggtca ctgtctcctc agcctccacc      420

aagggcccat ccgtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcc      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacgaagac ctacacctgc      660

aacgtagatc acaagcccag caacaccaag gtggacaaga gagttgagtc caaatatggt      720

cccccatgcc catcatgccc agcacctgag ttcctggggg gaccatcagt cttcctgttc      780

cccccaaaac ccaaggacac tctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg      840

gtggacgtga gccaggaaga ccccgaggtc cagttcaact ggtacgtgga tggcgtggag      900

gtgcataatg ccaagacaaa gccgcgggag gagcagttca acagcacgta ccgtgtggtc      960

agcgtcctca ccgtcctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc     1020

tccaacaaag gcctcccgtc ctccatcgag aaaaccatct ccaaagccaa agggcagccc     1080

cgagagccac aggtgtacac cctgccccca tcccaggagg agatgaccaa gaaccaggtc     1140

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc     1200

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1260

ttcttcctct acagcaggct aaccgtggac aagagcaggt ggcaggaggg gaatgtcttc     1320

tcatgctccg tgatgcatga ggctctgcac aaccactaca cacagaagag cctctccctg     1380

tctctcggga aatga                                                      1395


<210>  84
<211>  464
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  84

Met Met Ser Phe Val Ser Leu Leu Leu Val Gly Ile Leu Phe His Ala 
1               5                   10                  15      


Thr Gln Ala Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys 
            20                  25                  30          


Pro Thr Glu Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Arg Gly Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr 
65                  70                  75                  80  


Arg Thr Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Arg Arg Gly Gly Ile Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
225                 230                 235                 240 


Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460                 


<210>  85
<211>  1395
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  85
atgatgtcct ttgtctctct gctcctggtt ggcatcctat tccatgccac ccaggcccag       60

gtcaccttga aggagtctgg tcctgtgctg gtgaaaccca cagagaccct cacgctgacc      120

tgcaccgtct ctgggttctc actcagcagg ggtaaaatgg gtgtgagctg gatccgtcag      180

cccccaggga aggccctgga gtggcttgca cacatttttt cgagtgacga aaaatcctac      240

aggacatcgc tgaagagcag gctcaccatc tccaaggaca cctccaaaaa ccaggtggtc      300

cttacaatga ccaacatgga ccctgtggac acagccacgt attactgtgc acggatacga      360

cgtggaggaa ttgactactg gggccaggga accctggtca ctgtctcctc agcctccacc      420

aagggcccat ccgtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcc      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacgaagac ctacacctgc      660

aacgtagatc acaagcccag caacaccaag gtggacaaga gagttgagtc caaatatggt      720

cccccatgcc caccatgccc agcacctgag ttcctggggg gaccatcagt cttcctgttc      780

cccccaaaac ccaaggacac tctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg      840

gtggacgtga gccaggaaga ccccgaggtc cagttcaact ggtacgtgga tggcgtggag      900

gtgcataatg ccaagacaaa gccgcgggag gagcagttca acagcacgta ccgtgtggtc      960

agcgtcctca ccgtcctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc     1020

tccaacaaag gcctcccgtc ctccatcgag aaaaccatct ccaaagccaa agggcagccc     1080

cgagagccac aggtgtacac cctgccccca tcccaggagg agatgaccaa gaaccaggtc     1140

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc     1200

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1260

ttcttcctct acagcaggct aaccgtggac aagagcaggt ggcaggaggg gaatgtcttc     1320

tcatgctccg tgatgcatga ggctctgcac aaccactaca cacagaagag cctctccctg     1380

tctctcggga aatga                                                      1395


<210>  86
<211>  464
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  86

Met Met Ser Phe Val Ser Leu Leu Leu Val Gly Ile Leu Phe His Ala 
1               5                   10                  15      


Thr Gln Ala Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys 
            20                  25                  30          


Pro Thr Glu Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Arg Gly Lys Met Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala His Ile Phe Ser Ser Asp Glu Lys Ser Tyr 
65                  70                  75                  80  


Arg Thr Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Ile Arg Arg Gly Gly Ile Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
225                 230                 235                 240 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460                 


<210>  87
<211>  750
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  87
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc       60

acctgtgcca tctccgggga cagtgtctct agcaccagtg ctgcttggaa ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat      180

aatgattatg cagtatctgt gaaaagtcga ataaccatca acccagacac atccaagaac      240

cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca      300

agagatcctt tcggggtacc ttttgatatc tggggccaag ggacaatggt caccgtctct      360

tcaaagcttt cagggagtgc atccgcccca aaacttgaag aaggtgaatt ttcagaagca      420

cgcgtatcct atgagctgat acagccaccc tcggtgtcag tggccccagg acagacggcc      480

accattacct gtgcgggaga caaccttggg aagaaacgtg tgcactggta ccagcagagg      540

ccaggccagg cccctgtgtt ggtcatctat gatgatagcg accggccctc agggatccct      600

gaccgattct ctgcctccaa ctctgggaac acggccaccc tgaccatcac taggggcgaa      660

gccggggatg aggccgacta ttattgtcag gtgtgggaca ttgctactga tcatgtggtc      720

ttcggcggag ggaccaagct caccgtccta                                       750


<210>  88
<211>  735
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (663)..(663)
<223>  n is a, c, g, or t

<400>  88
caggtcacct tgaaggagtc tggtcctgtg ctggtgaaac ccacagagac cctcacgctg       60

acctgcaccg tctctgggtt ctcactcagc aggggtaaaa tgggtgtgag ctggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacacattt tttcgagtga cgaaaaatcc      180

tacaggacat cgctgaagag caggctcacc atctccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca cgtattactg tgcacggata      300

cgagcgggag gaattgacta ctggggccag ggaaccctgg tcactgtctc ctcaaagctt      360

tcagggagtg catccgcccc aaaacttgaa gaaggtgaat tttcagaagc acgcgtacag      420

ccagtgctga ctcagccccc ctcactgtcc gtgtccccag gacagacagc cagcatcacc      480

tgctctggag agaaattggg ggataaatat gcttactggt atcagcagaa gccaggccag      540

tcccctgtgt tggtcatgta tcaagataaa cagcggccct cagggatccc tgagcgattc      600

tctggctcca actctgggaa cacagccact ctgaccatca gcgggaccca ggctatggat      660

gangctgact attactgtca ggcgtgggac agcagcactg cggtattcgg cggagggacc      720

aagctgaccg tccta                                                       735


<210>  89
<211>  735
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (663)..(663)
<223>  n is a, c, g, or t

<400>  89
caggtcacct tgaaggagtc tggtcctgtg ctggtgaaac ccacagagac cctcacgctg       60

acctgcaccg tctctgggtt ctcactcagc aggggtaaaa tgggtgtgag ctggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacacattt tttcgagtga cgaaaaatcc      180

tacaggacat cgctgaagag caggctcacc atctccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca cgtattactg tgcacggata      300

cgacgtggag gaattgacta ctggggccag ggaaccctgg tcactgtctc ctcaaagctt      360

tcagggagtg catccgcccc aaaacttgaa gaaggtgaat tttcagaagc acgcgtacag      420

ccagtgctga ctcagccccc ctcactgtcc gtgtccccag gacagacagc cagcatcacc      480

tgctctggag agaaattggg ggataaatat gcttactggt atcagcagaa gccaggccag      540

tcccctgtgt tggtcatgta tcaagataaa cagcggccct cagggatccc tgagcgattc      600

tctggctcca actctgggaa cacagccact ctgaccatca gcgggaccca ggctatggat      660

gangctgact attactgtca ggcgtgggac agcagcactg cggtattcgg cggagggacc      720

aagctgaccg tccta                                                       735


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus CDRH3 of 17D20m and d3521N11


<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  wherein Xaa at position 8 is Ala or Arg

<400>  90

Tyr Tyr Cys Ala Arg Ile Arg Xaa 
1               5               


<210>  91
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  consensus of CDRL1 of 17D20m and d3521N11


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  wherein Xaa at position 2 is Asp or Glu

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  wherein Xaa at position 8 is Phe or Tyr

<400>  91

Gly Xaa Lys Leu Gly Asp Lys Xaa Ala Tyr Trp 
1               5                   10      


<210>  92
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  consensus CDRL1 of 17N16m and d17N9


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  wherein Xaa at position 2 is Asn or Asp

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  wherein Xaa at position 4 is Ile or Leu

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  wherein Xaa at position 6 is Ser or Lys

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  wherein Xaa at position 8 is Asn or Arg

<400>  92

Gly Xaa Asn Xaa Gly Xaa Lys Xaa Val His Trp 
1               5                   10      


<210>  93
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  consensus CDRL2 of 17D20m and d3521N11


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  wherein Xaa at position 2 is Asn or Lys or Ser

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  wherein Xaa at position 3 is Lys or Gln or Asp

<400>  93

Asp Xaa Xaa Arg Pro Ser Gly 
1               5           


<210>  94
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  consensus CDRL3 of 17N16m and d17N9


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  wherein Xaa at position 4 is Thr or Ile

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  wherein Xaa at position 5 is Thr or Ala

<400>  94

Val Trp Asp Xaa Xaa Thr Asp His Val 
1               5                   


