                         SEQUENCE LISTING

<110>  NVIP Pty Ltd
 
<120>  ANTI-NERVE GROWTH FACTOR ANTIBODIES AND METHODS OF PREPARING AND 
       USING THE SAME

<130>  P119712.WO.02

<150>  US61/483488
<151>  2011-05-06

<150>  US61/531439
<151>  2011-09-06

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full V+C light chain from chimeric

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Glu Cys Arg Ala Ser Glu Asp Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asp Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Ser Tyr Phe Cys Gln His Tyr Phe His Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Ala Gln 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp Glu Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe Tyr Pro Lys Glu Val 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Val Gln Thr Lys Ala Ser Lys 
145                 150                 155                 160 


Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Met Ser Arg Thr Glu Tyr Gln Ser His Glu Lys Phe 
            180                 185                 190         


Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser Thr Leu Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Ser Glu Cys Gln Arg Glu 
    210                 215         


<210>  2
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full V+C heavy chain from chimeric

<400>  2

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Thr Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Leu Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Leu Ser Asp Thr Phe Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Pro Ser Asn Thr Lys Val Asp Lys Thr Val Arg Lys Thr Asp 
    210                 215                 220                 


His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro 
225                 230                 235                 240 


Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val 
            260                 265                 270         


Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr Trp Phe Val Asp 
        275                 280                 285             


Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Pro His 
            340                 345                 350         


Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu Glu Leu Ser Arg 
        355                 360                 365             


Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe His Pro Pro Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Val 
                405                 410                 415     


Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln Arg Gly Asn Thr 
            420                 425                 430         


Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser His His Thr Gln 
        435                 440                 445             


Lys Ser Leu Thr Gln Ser Pro Gly Lys 
    450                 455         


<210>  3
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable domain from felinised

<400>  3

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Asp Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asp Thr Leu His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  


Asp Asp Val Gly Val Tyr Phe Cys Gln His Tyr Phe His Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  4
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable domain from felinised (HC derived from 
       BAA32229.1)

<400>  4

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  5
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full light chain from felinised

<400>  5

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Asp Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Arg Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asp Thr Leu His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  


Asp Asp Val Gly Val Tyr Phe Cys Gln His Tyr Phe His Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys Arg Ser Asp Ala Gln 
            100                 105                 110         


Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp Glu Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe Tyr Pro Lys Glu Val 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Val Gln Thr Lys Ala Ser Lys 
145                 150                 155                 160 


Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Met Ser Arg Thr Glu Tyr Gln Ser His Glu Lys Phe 
            180                 185                 190         


Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser Thr Leu Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Ser Glu Cys Gln Arg Glu 
    210                 215         


<210>  6
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full heavy chain from felinised (HC derived from BAA32229.1)

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Leu Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Leu Ser Asp Thr Phe Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Pro Ser Asn Thr Lys Val Asp Lys Thr Val Arg Lys Thr Asp 
    210                 215                 220                 


His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro 
225                 230                 235                 240 


Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val 
            260                 265                 270         


Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr Trp Phe Val Asp 
        275                 280                 285             


Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Pro His 
            340                 345                 350         


Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu Glu Leu Ser Arg 
        355                 360                 365             


Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe His Pro Pro Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Val 
                405                 410                 415     


Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln Arg Gly Asn Thr 
            420                 425                 430         


Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser His His Thr Gln 
        435                 440                 445             


Lys Ser Leu Thr Gln Ser Pro Gly Lys 
    450                 455         


<210>  7
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aglycosylated full heavy chain from felinised (modified HC from 
       BAA32229.1)

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Leu Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Leu Ser Asp Thr Phe Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Pro Ser Asn Thr Lys Val Asp Lys Thr Val Arg Lys Thr Asp 
    210                 215                 220                 


His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro 
225                 230                 235                 240 


Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val 
            260                 265                 270         


Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr Trp Phe Val Asp 
        275                 280                 285             


Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Pro His 
            340                 345                 350         


Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu Glu Leu Ser Arg 
        355                 360                 365             


Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe His Pro Pro Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Val 
                405                 410                 415     


Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln Arg Gly Asn Thr 
            420                 425                 430         


Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser His His Thr Gln 
        435                 440                 445             


Lys Ser Leu Thr Gln Ser Pro Gly Lys 
    450                 455         


<210>  8
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain FR1

<400>  8

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys 
            20              


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain FR2

<400>  9

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  10
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain FR3

<400>  10

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Arg Ile Ser Arg Val Glu Ala Asp Asp Val Gly Val Tyr Phe Cys 
            20                  25                  30          


Gln 
    


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain FR4

<400>  11

Phe Gly Pro Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  12
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain FR1

<400>  12

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Ser Leu Thr 
            20                  25                  30  


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain FR2

<400>  13

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  14
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain FR3

<400>  14

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain FR4

<400>  15

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  16
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternate full V+C heavy chain chimera (Chimeric anti-NGF 
       alternate HC constant domain from BAA32230.1)

<400>  16

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Thr Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Leu Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Leu Ser Asp Thr Phe Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Pro Ser Asn Thr Lys Val Asp Lys Thr Val Arg Lys Thr Asp 
    210                 215                 220                 


His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro 
225                 230                 235                 240 


Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val 
            260                 265                 270         


Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr Trp Phe Val Asp 
        275                 280                 285             


Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys Gly Gln Pro His 
            340                 345                 350         


Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu Glu Leu Ser Arg 
        355                 360                 365             


Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Leu 
                405                 410                 415     


Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln Arg Gly Asn Thr 
            420                 425                 430         


Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser His His Thr Gln 
        435                 440                 445             


Lys Ser Leu Thr Gln Ser Pro Gly Lys 
    450                 455         


<210>  17
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternate full heavy chain from felinised (Felinised anti-NGF V 
       domain fused to alternate HC constant domain from BAA32230.1)

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Leu Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Leu Ser Asp Thr Phe Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Pro Ser Asn Thr Lys Val Asp Lys Thr Val Arg Lys Thr Asp 
    210                 215                 220                 


His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro 
225                 230                 235                 240 


Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val 
            260                 265                 270         


Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr Trp Phe Val Asp 
        275                 280                 285             


Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys Gly Gln Pro His 
            340                 345                 350         


Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu Glu Leu Ser Arg 
        355                 360                 365             


Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Leu 
                405                 410                 415     


Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln Arg Gly Asn Thr 
            420                 425                 430         


Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser His His Thr Gln 
        435                 440                 445             


Lys Ser Leu Thr Gln Ser Pro Gly Lys 
    450                 455         


<210>  18
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Aglycosyl Alternate full heavy chain from felinised (Felinised 
       anti-NGF V domain fused to alternate HC constant domain from 
       BAA32230.1, with N-glycolylation site substituted)

<400>  18

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Leu Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Leu Ser Asp Thr Phe Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Pro Ser Asn Thr Lys Val Asp Lys Thr Val Arg Lys Thr Asp 
    210                 215                 220                 


His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro 
225                 230                 235                 240 


Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val 
            260                 265                 270         


Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr Trp Phe Val Asp 
        275                 280                 285             


Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Asp Lys Gly Gln Pro His 
            340                 345                 350         


Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu Glu Leu Ser Arg 
        355                 360                 365             


Asn Lys Val Ser Val Thr Cys Leu Ile Glu Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Leu 
                405                 410                 415     


Tyr Ser Arg Leu Ser Val Asp Arg Ser Arg Trp Gln Arg Gly Asn Thr 
            420                 425                 430         


Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser His His Thr Gln 
        435                 440                 445             


Lys Ser Leu Thr Gln Ser Pro Gly Lys 
    450                 455         


<210>  19
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Aglycosyl chimeric HC (derived from SEQ ID NO:2)

<400>  19

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Thr Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Thr Thr Ser Gly Ala Thr 
    130                 135                 140                 


Val Ala Leu Ala Cys Leu Val Leu Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr 
            180                 185                 190         


Val Pro Ser Ser Arg Trp Leu Ser Asp Thr Phe Thr Cys Asn Val Ala 
        195                 200                 205             


His Pro Pro Ser Asn Thr Lys Val Asp Lys Thr Val Arg Lys Thr Asp 
    210                 215                 220                 


His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys Cys Pro Pro Pro 
225                 230                 235                 240 


Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr Cys Leu Val Val 
            260                 265                 270         


Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr Trp Phe Val Asp 
        275                 280                 285             


Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn Ser Lys Ser Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys Gly Gln Pro His 
            340                 345                 350         


Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu Glu Leu Ser Arg 
        355                 360                 365             


Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe His Pro Pro Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly Thr Tyr Phe Val 
                405                 410                 415     


Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln Arg Gly Asn Thr 
            420                 425                 430         


Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser His His Thr Gln 
        435                 440                 445             


Lys Ser Leu Thr Gln Ser Pro Gly Lys 
    450                 455         


<210>  20
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain of chimeric feline-rat antibody with leader sequence

<400>  20

Met Gly Val Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp Ile Thr 
1               5                   10                  15      


Asp Ala Ile Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Glu Thr Val Thr Ile Glu Cys Arg Ala Ser Glu Asp 
        35                  40                  45              


Ile Tyr Asn Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Gln Leu Leu Ile Tyr Asn Thr Asp Thr Leu His Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn 
                85                  90                  95      


Ser Leu Gln Ser Glu Asp Val Ala Ser Tyr Phe Cys Gln His Tyr Phe 
            100                 105                 110         


His Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             


Ser Asp Ala Gln Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp Glu 
    130                 135                 140                 


Leu His Thr Gly Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe Tyr 
145                 150                 155                 160 


Pro Lys Glu Val Asn Val Lys Trp Lys Val Asp Gly Val Val Gln Thr 
                165                 170                 175     


Lys Ala Ser Lys Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Arg Thr Glu Tyr Gln Ser 
        195                 200                 205             


His Glu Lys Phe Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser Thr 
    210                 215                 220                 


Leu Val Lys Ser Phe Asn Arg Ser Glu Cys Gln Arg Glu 
225                 230                 235         


<210>  21
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain of chimeric feline-rat antibody with leader sequence

<400>  21

Met Ala Val Leu Val Leu Leu Leu Cys Leu Val Thr Phe Pro Thr Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Asn Asn Val Asn Trp Val Arg Gln Ala Thr Gly Arg Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Lys Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met 
        115                 120                 125             


Asp Ala Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Thr Thr Ser 
145                 150                 155                 160 


Gly Ala Thr Val Ala Leu Ala Cys Leu Val Leu Gly Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Met Val Thr Val Pro Ser Ser Arg Trp Leu Ser Asp Thr Phe Thr Cys 
    210                 215                 220                 


Asn Val Ala His Pro Pro Ser Asn Thr Lys Val Asp Lys Thr Val Arg 
225                 230                 235                 240 


Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys Cys 
                245                 250                 255     


Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr Trp 
    290                 295                 300                 


Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Leu 
                325                 330                 335     


His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn Ser 
            340                 345                 350         


Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu Glu 
    370                 375                 380                 


Leu Ser Arg Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe His 
385                 390                 395                 400 


Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu Pro 
                405                 410                 415     


Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly Thr 
            420                 425                 430         


Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln Arg 
        435                 440                 445             


Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser His 
    450                 455                 460                 


His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
465                 470                 475     


<210>  22
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative felinised anti-NGF VH heavy chain (feN2-VH)

<400>  22

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Asn 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ala 
        115                 120         


<210>  23
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative felinised anti-NGF Vk light chain (feN2-Vk)

<400>  23

Asp Ile Glu Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ala Ser Glu Asp Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Leu Gln Lys Pro Gly Arg Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asp Thr Leu His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Gln Thr 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Phe Cys Gln His Tyr Phe His Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  24
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative complete feline anti-NGF IgG heavy chain (feN2-HC2)

<400>  24

Met Ala Val Leu Val Leu Leu Leu Cys Leu Val Thr Phe Pro Thr Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Val Glu Ser Gly Ala Glu Leu Val Gln 
            20                  25                  30          


Pro Gly Glu Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Asn Asn Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Val Trp Ala Gly Gly Ala Thr Asp Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Asn Thr 
                85                  90                  95      


Val Phe Leu Gln Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Gly Gly Tyr Ser Ser Ser Thr Leu Tyr Ala Met 
        115                 120                 125             


Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Ala Ser Thr 
    130                 135                 140                 


Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Thr Thr Ser 
145                 150                 155                 160 


Gly Ala Thr Val Ala Leu Ala Cys Leu Val Leu Gly Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Met Val Thr Val Pro Ser Ser Arg Trp Leu Ser Asp Thr Phe Thr Cys 
    210                 215                 220                 


Asn Val Ala His Pro Pro Ser Asn Thr Lys Val Asp Lys Thr Val Arg 
225                 230                 235                 240 


Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys Pro Lys Cys 
                245                 250                 255     


Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln Ile Thr Trp 
    290                 295                 300                 


Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Leu 
                325                 330                 335     


His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys Val Asn Ser 
            340                 345                 350         


Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala Gln Glu Glu 
    370                 375                 380                 


Leu Ser Arg Asn Lys Val Ser Val Thr Cys Leu Ile Lys Ser Phe His 
385                 390                 395                 400 


Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln Pro Glu Pro 
                405                 410                 415     


Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser Asp Gly Thr 
            420                 425                 430         


Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His Trp Gln Arg 
        435                 440                 445             


Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu His Ser His 
    450                 455                 460                 


His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
465                 470                 475     


<210>  25
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative complete feline anti-NGF IgG kappa light chain 
       (feN2-kLC)

<400>  25

Met Gly Val Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp Ile Thr 
1               5                   10                  15      


Asp Ala Ile Cys Asp Ile Glu Met Thr Gln Ser Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ala Ser Glu Asp 
        35                  40                  45              


Ile Tyr Asn Ala Leu Ala Trp Tyr Leu Gln Lys Pro Gly Arg Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asn Thr Asp Thr Leu His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
                85                  90                  95      


Arg Val Gln Thr Glu Asp Val Gly Val Tyr Phe Cys Gln His Tyr Phe 
            100                 105                 110         


His Tyr Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             


Ser Asp Ala Gln Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp Glu 
    130                 135                 140                 


Leu His Thr Gly Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe Tyr 
145                 150                 155                 160 


Pro Lys Glu Val Asn Val Lys Trp Lys Val Asp Gly Val Val Gln Thr 
                165                 170                 175     


Lys Ala Ser Lys Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Arg Thr Glu Tyr Gln Ser 
        195                 200                 205             


His Glu Lys Phe Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser Thr 
    210                 215                 220                 


Leu Val Lys Ser Phe Asn Arg Ser Glu Cys Gln Arg Glu 
225                 230                 235         


<210>  26
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative light chain FR1 (feN2-kLC)

<400>  26

Asp Ile Glu Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys 
            20              


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative light chain FR2 (feN2-kLC)

<400>  27

Trp Tyr Leu Gln Lys Pro Gly Arg Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  28
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative light chain FR3 (feN2-kLC)

<400>  28

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Gln Thr Glu Asp Val Gly Val Tyr Phe Cys 
            20                  25                  30          


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative light chain FR4 (feN2-kLC)

<400>  29

Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  30
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative heavy chain FR1 (feN2-VH)

<400>  30

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly 
            20                  25      


<210>  31
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative heavy chain FR2 (feN2-VH)

<400>  31

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  32
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative heavy chain FR3 (feN2-VH)

<400>  32

Arg Leu Thr Ile Thr Arg Asp Thr Ser Lys Asn Thr Val Phe Leu Gln 
1               5                   10                  15      


Met His Ser Leu Gln Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative heavy chain FR4 (feN2-VH)

<400>  33

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala 
1               5                   10      


