                         SEQUENCE LISTING

<110>  Ironwood Pharmaceuticals, Inc.
       Currie, Mark G.
       Zimmer, Daniel P.
       Kessler, Mark
 
<120>  Treatments for Gastrointestinal Disorders

<130>  223355/109PCT1/327409

<140>  PCT/US12/xxxxxx
<141>  2012-05-08

<150>  61/485,060
<151>  2011-05-11

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa1 is Ser, Asn, Tyr, Ala, Gln, Pro, Lys, Gly or Thr, or is 
       missing

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa2 is His, Asp, Glu, Ala, Ser, Asn, Gly, or is missing

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa3 is Thr, Asp, Ser, Glu, Pro, Val or Leu

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa6 is Ile, Trp or Leu

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa7 is Cys, Ser, or Tyr

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa8 is Ala, Val, Thr, Ile, Met or is missing

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa9 is a) any amino acid, b) Phe, Tyr, Asn, Trp, c) an amino 
       acid other than Phe, Trp, or Tyr, d) non-aromatic amino acid or 
       e) is missing

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa10 is Ala, Val, Met, Thr or Ile

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa11 is Ala or Val

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa11 is Ala or Thr

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa14 Gly, Ala or Ser

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa15 is Cys, Tyr or is missing

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa16 is Trp, Tyr, Phe, Lys, Arg, His, Leu, Ser or is missing

<400>  1

Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa 
1               5                   10                  15      


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa1 is Ser, Asn, Tyr, Ala, Gln, Pro, Lys, Gly, or Thr or is 
       missing

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa2 is His, Asp, Glu, Ala, Ser, Asn, Gly, Pro or is missing

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa3 is Thr, Asp, Ser, Glu, Pro, Val or Leu

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa5 is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa6 is Ile, Trp or Leu

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa7 is Cys, Ser, or Tyr

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa8 is Ala, Val, Thr, Ile, Met or is missing

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa9 is Phe, Tyr, Asn, Trp, an amino acid other than Phe, Trp, or
       Tyr, is a non-aromatic amino acid or is missing

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa10 is Ala, Val, Met, Thr, or Ile

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa11 is Ala or Val

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa13 is Ala or Thr

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa14 is Gly, Ala or Ser

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa15 is Cys, Tyr or is missing

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa16 is Trp, Tyr, Phe, Lys, Arg, His, Leu, Ser or is missing

<400>  2

Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa 
1               5                   10                  15      


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa1 is Asn, any amino acid or is missing

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa2 is Asp, Glu, any amino acid or is missing

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa3 is Asp or Glu

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa5 is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa6 is any amino acid or Leu

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa7 is Cys

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa8 is any amino acid or Val

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa9 is Asn, Gln, Tyr

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa10 is any amino acid or Val

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa11 is any amino acid or Ala

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa13 is any amino acid or Thr

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa14 is any amino acid or Gly

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa15 is Cys

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa16 is any amino acid, Leu or missing

<400>  3

Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa 
1               5                   10                  15      


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa2 is Asp or Glu

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa3 is Asp or Glu

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa4 is cys or Mpt or Pen or Dpr or Asp or Glu

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa5 is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa7 is Cys or Mpt or Pen or Dpr or Asp or Glu

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa10 is Val or Pro

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa11 is Ala or Aib

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa12 is Cys or Mpt or Pen or Dpr or Asp or Glu

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa14 is Gly or Ala

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa15 is Cys or Mpt or Pen or Dpr or Asp or Glu

<400>  4

Asn Xaa Xaa Xaa Xaa Leu Xaa Val Asn Xaa Xaa Xaa Thr Xaa Xaa Leu 
1               5                   10                  15      


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa6 is P-Ser, P-thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  5

Lys Pro Gly Thr Cys Xaa Ile Cys Ala Tyr Ala Ala Cys Thr Gly Cys 
1               5                   10                  15      


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa5 is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<220>
<221>  VARIANT
<222>  (9)..(9)

<400>  6

Pro Gly Thr Cys Xaa Ile Cys Ala Tyr Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  7

Pro Gly Thr Cys Xaa Ile Cys Ala Ser Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  8

Pro Gly Thr Cys Xaa Ile Cys Ala Thr Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  9

Pro Gly Thr Cys Xaa Ile Cys Ala Asn Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  10

Pro Gly Thr Cys Xaa Ile Cys Ala Gln Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  11

Pro Gly Thr Cys Xaa Ile Cys Ala Arg Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  12

Pro Gly Thr Cys Xaa Ile Cys Ala Glu Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  13

Pro Gly Thr Cys Ser Ile Cys Ala Asp Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  14

Pro Gly Thr Cys Xaa Ile Cys Ala Gly Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  15

Pro Gly Thr Cys Xaa Ile Cys Ala Ala Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated sequence


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  16

Pro Gly Thr Cys Xaa Ile Cys Ala Met Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  17

Pro Gly Thr Cys Xaa Ile Cys Ala Ile Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  18

Pro Gly Thr Cys Xaa Ile Cys Ala Leu Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  19

Pro Gly Thr Cys Xaa Ile Cys Ala Val Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<400>  20

Pro Gly Thr Cys Xaa Ile Cys Ala His Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa5 is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Cys Xaa Xaa Cys Xaa Xaa Xaa Xaa Cys Xaa Xaa Cys 
1               5                   10          


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa1 is Gly, Asn, Pro, Gln, Ser, Thr, Ala, Val, Leu, Ile, Met, 
       Phe, Trp, Tyr or is absent

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa2 is Asp, Glu, Gly, His, Asn, Ser, Gln, Thr or is absent

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa3 is Thr, Glu, Asp, or Ser

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa5 is P-Ser, p-Thr, p-homo-Ser, 4-hydroxyvaline phosphate, 
       P-homo-Thr, P-Cys or P-Tyr

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa6 is Ile or Leu

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa8 is Val, Ile, Ala or Leu

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa9 is Asn, Tyr, Phe or Gln

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa10 is Val, Ile, Ala, Leu or Pro

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa13 is Ala, Ser or Thr

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa14 is Gly or Ala

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa16 is Leu, Ile, Phe, Trp, Tyr, or is absent

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa17 is Arg, Lys, Ala, Leu, Val, Ile, Ser, Thr, Met, Phe, Trp, 
       Tyr, Asp, Glu, Gln Asn or is absent

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  Xaa18 is Arg, Lys, Ala, Leu, Val, Ile, Ser, Thr, Met, Phe, Trp, 
       Tyr, Asp, Glu, Gln, Asn or is absent

<400>  22

Xaa Xaa Xaa Cys Xaa Xaa Cys Xaa Xaa Xaa Ala Cys Xaa Xaa Cys Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa1 is Gly, Asn, Gln, Thr, or is absent

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa2 is Asp, Glu, or is absent

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa3 is Glu or Asp

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa10 is p-Ser, p-Thr, p-homo-Ser, 4-hydroxyvaline phosphate, 
       p-homo-Thr, p-Cys or p-Tyr

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa8 is Val or Ile

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa10 is Val or Ile

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa16 is Leu, Phe, Tyr, or is absent

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa17 is Arg, Lys, Ala, Leu, Val, Ile, Ser, Thr, Met, Phe, Trp, 
       Tyr, Asp, Glu, Gln, Asn or is absent

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  Xaa18 is Arg, Lys, Ala, Leu, Val, Ile, Ser, Thr, Met, phe, Trp, 
       Tyr, Asp, Glu, Gln, Asn or is absent

<400>  23

Xaa Xaa Xaa Cys Xaa Leu Cys Xaa Asn Xaa Ala Cys Thr Gly Cys Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa1 is Pro, Ser, or is absent

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa2 is Gly, His, Asn, Ser, or is absent

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa5 is p-Ser, p-Thr, p-homo-Ser, 4-hydroxyvaline phosphate, 
       p-homo-Thr, p-Cys or p-Tyr

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa9 is Tyr or Phe

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa13 is Ala or Thr

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa16 is Leu, Phe, Tyr, or is absent

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa17 is Arg, Lys, Ala, Leu, Val, Ile, Ser, Thr, Met, Phe, Trp, 
       Tyr, Asp, Glu, Gln, Asn or is absent

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  Xaa18 is Arg, Lys, Ala, Leu, Val, Ile, Ser, Thr, Met, Phe, Trp, 
       Tyr, Asp, Glu, Gln, Asn or is absent

<400>  24

Xaa Xaa Thr Cys Xaa Ile Cys Ala Xaa Ala Ala Cys Xaa Gly Cys Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  25
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa1 is Gly, Asn, Pro, Gln, Ser, Thr, Ala, Val, Leu, Ile, Met, 
       Phe, Trp, Tyr or is absent

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa2 is Asp, Glu, Gly, His, Asn, Ser, Gln, Thr or is absent

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa3 is Thr, Glu, Asp, or Ser

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa6 is Ile or Leu

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa8 is Val, Ile, Ala, or Leu

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa9 is Asn, Tyr, Phe, or Gln

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa10 is Val, Ile, Ala, Leu or Pro

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa13 is Ala, Ser or Thr

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa14 is Gly or Ala

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa16 is Leu, Ile, Phe, Trp, Tyr, or is absent

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa17 is Arg, Lys, Ala, Leu, Val, Ile, Ser, Thr, Met, Phe, Trp, 
       Tyr, Asp, Glu, Gln, Asn or is absent

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  Xaa18 is Arg, Lys, Ala, Leu, Val, Ile, Ser, Thr, Met, Phe, Trp, 
       Tyr, Asp, Glu, Gln, Asn or is absent

<400>  25

Xaa Xaa Xaa Cys Glu Xaa Cys Xaa Xaa Xaa Ala Cys Xaa Xaa Cys Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  26
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa1 is Gly, Asn, Gln, Thr, or is absent

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa2 is Asp, Glu, or is absent

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa3 is Glu or Asp

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa8 is Val or Ile

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa10 is Val or Ile

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa16 is Leu, Phe, Tyr, or is absent

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa17 is Arg, Lys, Ala, Leu, Val, Ile, Ser, Thr, Met, Phe, Trp, 
       Tyr, Asp, Glu, Gln, Asn or is absent

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  Xaa9 is Arg, Lys, Ala, Leu, Val, Ile, Ser, Thr, Met, Phe, Trp, 
       Tyr, Asp, Glu, Gln, Asn or is absent

<400>  26

Xaa Xaa Xaa Cys Glu Leu Cys Xaa Asn Xaa Ala Cys Thr Gly Cys Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  27
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa1 is Pro, Ser, or is absent

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa2 is Gly, His, Asn, Ser, or is absent

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa9 is Tyr or Phe

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa13 is Ala or Thr

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa16 is Leu, Phe, Tyr, or is absent

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa17 is Arg, Lys, Ala, Leu, Val, Ile, Ser, Thr, Met, Phe, Trp, 
       Tyr, Asp, Glu, Gln, Asn or is absent

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  Xaa18 is Arg, Lys, Ala, Leu, Val, Ile, Ser, Thr, Met, Phe, Trp, 
       Tyr, Asp, Glu, Gln, Asn or is absent

<400>  27

Xaa Xaa Thr Cys Glu Ile Cys Ala Xaa Ala Ala Cys Xaa Gly Cys Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210>  28
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa5 is p-Ser

<400>  28

Pro Gly Thr Cys Xaa Ile Cys Ala Tyr Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa5 is p-Ser

<400>  29

Asn Asp Asp Cys Xaa Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu 
1               5                   10                  15      


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa5 is p-Ser

<400>  30

Asn Asp Glu Cys Xaa Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu 
1               5                   10                  15      


<210>  31
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetically generated peptide

<400>  31

Asn Thr Phe Tyr Cys Cys Glu Leu Cys Cys Asn Pro Ala Cys Ala Gly 
1               5                   10                  15      


Cys Tyr 

        


<210>  32
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  32

Asn Asp Asp Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu 
1               5                   10                  15      


<210>  33
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  33

Pro Gly Thr Cys Glu Ile Cys Ala Tyr Ala Ala Cys Thr Gly Cys 
1               5                   10                  15  



        


