                         SEQUENCE LISTING

<110>  Syntaxin Limited
       Chaddock, John
       Harper, Elaine
 
<120>  Therapeutic fusion proteins

<130>  P35972WO-MRM

<140>  Not yet assigned
<141>  2012-05-16

<150>  GB1108108.0
<151>  2011-05-16

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  2769
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  1
atgcatcacc atcaccatca ccatcaccat catgggagct cgaacaataa caacaataac       60

aataacaata acggatccat gacgtggcca gttaaggatt tcaactactc agatcctgta      120

aatgacaacg atattctgta ccttcgcatt ccacaaaata aactgatcac cacaccagtc      180

aaagcattca tgattactca aaacatttgg gtcattccag aacgcttttc tagtgacaca      240

aatccgagtt tatctaaacc tccgcgtccg acgtccaaat atcagagcta ttacgatccc      300

tcatatctca gtacggacga acaaaaagat actttcctta aaggtatcat taaactgttt      360

aagcgtatta atgagcgcga tatcgggaaa aagttgatta attatcttgt tgtgggttcc      420

ccgttcatgg gcgatagctc tacccccgaa gacacttttg attttacccg tcatacgaca      480

aacatcgcgg tagagaagtt tgagaacgga tcgtggaaag tcacaaacat cattacacct      540

agcgtcttaa tttttggtcc gctgccaaac atcttagatt atacagccag cctgactttg      600

caggggcaac agtcgaatcc gagtttcgaa ggttttggta ccctgagcat tctgaaagtt      660

gccccggaat ttctgctcac tttttcagat gtcaccagca accagagctc agcagtatta      720

ggaaagtcaa ttttttgcat ggacccggtt attgcactga tgcacgaact gacgcactct      780

ctgcatcaac tgtatgggat caacatcccc agtgacaaac gtattcgtcc ccaggtgtct      840

gaaggatttt tctcacagga tgggccgaac gtccagttcg aagagttgta tactttcgga      900

ggcctggacg tagagatcat tccccagatt gagcgcagtc agctgcgtga gaaggcattg      960

ggccattata aggatattgc aaaacgcctg aataacatta acaaaacgat tccatcttcg     1020

tggatctcga atattgataa atataagaaa atttttagcg agaaatataa ttttgataaa     1080

gataatacag gtaactttgt ggttaacatt gacaaattca actcccttta cagtgatttg     1140

acgaatgtaa tgagcgaagt tgtgtatagt tcccaataca acgttaagaa tcgtacccat     1200

tacttctctc gtcactacct gccggttttc gcgaacatcc ttgacgataa tatttacact     1260

attcgtgacg gctttaactt gaccaacaag ggcttcaata ttgaaaattc aggccagaac     1320

attgaacgca acccggcctt gcagaaactg tcgagtgaat ccgtggttga cctgtttacc     1380

aaagtctgcg tcgacggcat cattacctcc aaaactaaat ctctgataga aggtagaaac     1440

aaagcgctga acctgcagtg tattaaagtg aaaaacaatc ggctgcctta tgtagcagat     1500

aaagatagca ttagtcagga gattttcgaa aataaaatta tcactgacga aaccaatgtt     1560

cagaattatt cagataaatt ttcactggac gaaagcatct tagatggcca agttccgatt     1620

aacccggaaa ttgttgatcc gttactgccg aacgtgaata tggaaccgtt aaacctccct     1680

ggcgaagaga tcgtatttta tgatgacatt acgaaatatg tggactacct taattcttat     1740

tactatttgg aaagccagaa actgtccaat aacgtggaaa acattactct gaccacaagc     1800

gtggaagagg ctttaggcta ctcaaataag atttatacct tcctcccgtc gctggcggaa     1860

aaagtaaata aaggtgtgca ggctggtctg ttcctcaact gggcgaatga agttgtcgaa     1920

gactttacca cgaatattat gaaaaaggat accctggata aaatctccga cgtctcggtt     1980

attatcccat atattggccc tgcgttaaat atcggtaata gtgcgctgcg ggggaatttt     2040

aaccaggcct ttgctaccgc gggcgtcgcg ttcctcctgg agggctttcc tgaatttact     2100

atcccggcgc tcggtgtttt tacattttac tcttccatcc aggagcgtga gaaaattatc     2160

aaaaccatcg aaaactgcct ggagcagcgg gtgaaacgct ggaaagattc ttatcaatgg     2220

atggtgtcaa actggttatc tcgcatcacg acccaattca accatattaa ttaccagatg     2280

tatgatagtc tgtcgtacca agctgacgcc attaaagcca aaattgatct ggaatataaa     2340

aagtactctg gtagcgataa ggagaacatc aaaagccagg tggagaacct taagaatagt     2400

ctggatgtga aaatctctga agctatgaat aacattaaca aattcattcg tgaatgttcg     2460

gtgacgtacc tgttcaagaa tatgctgcca aaagttattg atgaactgaa taaatttgat     2520

ctgcgtacca aaaccgaact tatcaacctc atcgactccc acaacattat ccttgtgggc     2580

gaagtggatc gtctgaaggc caaagtaaac gagagctttg aaaatacgat gccgtttaat     2640

attttttcat ataccaataa ctccttgctg aaagatatca tcaatgaata tttcaatcta     2700

gaatgtggcg gtggcggtag catcgaaggt cgtcagcact ggtcctattg cctgcgccct     2760

ggttgataa                                                             2769


<210>  2
<211>  921
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  2

Met His His His His His His His His His His Gly Ser Ser Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Asn Asn Asn Asn Gly Ser Met Thr Trp Pro Val Lys 
            20                  25                  30          


Asp Phe Asn Tyr Ser Asp Pro Val Asn Asp Asn Asp Ile Leu Tyr Leu 
        35                  40                  45              


Arg Ile Pro Gln Asn Lys Leu Ile Thr Thr Pro Val Lys Ala Phe Met 
    50                  55                  60                  


Ile Thr Gln Asn Ile Trp Val Ile Pro Glu Arg Phe Ser Ser Asp Thr 
65                  70                  75                  80  


Asn Pro Ser Leu Ser Lys Pro Pro Arg Pro Thr Ser Lys Tyr Gln Ser 
                85                  90                  95      


Tyr Tyr Asp Pro Ser Tyr Leu Ser Thr Asp Glu Gln Lys Asp Thr Phe 
            100                 105                 110         


Leu Lys Gly Ile Ile Lys Leu Phe Lys Arg Ile Asn Glu Arg Asp Ile 
        115                 120                 125             


Gly Lys Lys Leu Ile Asn Tyr Leu Val Val Gly Ser Pro Phe Met Gly 
    130                 135                 140                 


Asp Ser Ser Thr Pro Glu Asp Thr Phe Asp Phe Thr Arg His Thr Thr 
145                 150                 155                 160 


Asn Ile Ala Val Glu Lys Phe Glu Asn Gly Ser Trp Lys Val Thr Asn 
                165                 170                 175     


Ile Ile Thr Pro Ser Val Leu Ile Phe Gly Pro Leu Pro Asn Ile Leu 
            180                 185                 190         


Asp Tyr Thr Ala Ser Leu Thr Leu Gln Gly Gln Gln Ser Asn Pro Ser 
        195                 200                 205             


Phe Glu Gly Phe Gly Thr Leu Ser Ile Leu Lys Val Ala Pro Glu Phe 
    210                 215                 220                 


Leu Leu Thr Phe Ser Asp Val Thr Ser Asn Gln Ser Ser Ala Val Leu 
225                 230                 235                 240 


Gly Lys Ser Ile Phe Cys Met Asp Pro Val Ile Ala Leu Met His Glu 
                245                 250                 255     


Leu Thr His Ser Leu His Gln Leu Tyr Gly Ile Asn Ile Pro Ser Asp 
            260                 265                 270         


Lys Arg Ile Arg Pro Gln Val Ser Glu Gly Phe Phe Ser Gln Asp Gly 
        275                 280                 285             


Pro Asn Val Gln Phe Glu Glu Leu Tyr Thr Phe Gly Gly Leu Asp Val 
    290                 295                 300                 


Glu Ile Ile Pro Gln Ile Glu Arg Ser Gln Leu Arg Glu Lys Ala Leu 
305                 310                 315                 320 


Gly His Tyr Lys Asp Ile Ala Lys Arg Leu Asn Asn Ile Asn Lys Thr 
                325                 330                 335     


Ile Pro Ser Ser Trp Ile Ser Asn Ile Asp Lys Tyr Lys Lys Ile Phe 
            340                 345                 350         


Ser Glu Lys Tyr Asn Phe Asp Lys Asp Asn Thr Gly Asn Phe Val Val 
        355                 360                 365             


Asn Ile Asp Lys Phe Asn Ser Leu Tyr Ser Asp Leu Thr Asn Val Met 
    370                 375                 380                 


Ser Glu Val Val Tyr Ser Ser Gln Tyr Asn Val Lys Asn Arg Thr His 
385                 390                 395                 400 


Tyr Phe Ser Arg His Tyr Leu Pro Val Phe Ala Asn Ile Leu Asp Asp 
                405                 410                 415     


Asn Ile Tyr Thr Ile Arg Asp Gly Phe Asn Leu Thr Asn Lys Gly Phe 
            420                 425                 430         


Asn Ile Glu Asn Ser Gly Gln Asn Ile Glu Arg Asn Pro Ala Leu Gln 
        435                 440                 445             


Lys Leu Ser Ser Glu Ser Val Val Asp Leu Phe Thr Lys Val Cys Val 
    450                 455                 460                 


Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu Gly Arg Asn 
465                 470                 475                 480 


Lys Ala Leu Asn Leu Gln Cys Ile Lys Val Lys Asn Asn Arg Leu Pro 
                485                 490                 495     


Tyr Val Ala Asp Lys Asp Ser Ile Ser Gln Glu Ile Phe Glu Asn Lys 
            500                 505                 510         


Ile Ile Thr Asp Glu Thr Asn Val Gln Asn Tyr Ser Asp Lys Phe Ser 
        515                 520                 525             


Leu Asp Glu Ser Ile Leu Asp Gly Gln Val Pro Ile Asn Pro Glu Ile 
    530                 535                 540                 


Val Asp Pro Leu Leu Pro Asn Val Asn Met Glu Pro Leu Asn Leu Pro 
545                 550                 555                 560 


Gly Glu Glu Ile Val Phe Tyr Asp Asp Ile Thr Lys Tyr Val Asp Tyr 
                565                 570                 575     


Leu Asn Ser Tyr Tyr Tyr Leu Glu Ser Gln Lys Leu Ser Asn Asn Val 
            580                 585                 590         


Glu Asn Ile Thr Leu Thr Thr Ser Val Glu Glu Ala Leu Gly Tyr Ser 
        595                 600                 605             


Asn Lys Ile Tyr Thr Phe Leu Pro Ser Leu Ala Glu Lys Val Asn Lys 
    610                 615                 620                 


Gly Val Gln Ala Gly Leu Phe Leu Asn Trp Ala Asn Glu Val Val Glu 
625                 630                 635                 640 


Asp Phe Thr Thr Asn Ile Met Lys Lys Asp Thr Leu Asp Lys Ile Ser 
                645                 650                 655     


Asp Val Ser Val Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly 
            660                 665                 670         


Asn Ser Ala Leu Arg Gly Asn Phe Asn Gln Ala Phe Ala Thr Ala Gly 
        675                 680                 685             


Val Ala Phe Leu Leu Glu Gly Phe Pro Glu Phe Thr Ile Pro Ala Leu 
    690                 695                 700                 


Gly Val Phe Thr Phe Tyr Ser Ser Ile Gln Glu Arg Glu Lys Ile Ile 
705                 710                 715                 720 


Lys Thr Ile Glu Asn Cys Leu Glu Gln Arg Val Lys Arg Trp Lys Asp 
                725                 730                 735     


Ser Tyr Gln Trp Met Val Ser Asn Trp Leu Ser Arg Ile Thr Thr Gln 
            740                 745                 750         


Phe Asn His Ile Asn Tyr Gln Met Tyr Asp Ser Leu Ser Tyr Gln Ala 
        755                 760                 765             


Asp Ala Ile Lys Ala Lys Ile Asp Leu Glu Tyr Lys Lys Tyr Ser Gly 
    770                 775                 780                 


Ser Asp Lys Glu Asn Ile Lys Ser Gln Val Glu Asn Leu Lys Asn Ser 
785                 790                 795                 800 


Leu Asp Val Lys Ile Ser Glu Ala Met Asn Asn Ile Asn Lys Phe Ile 
                805                 810                 815     


Arg Glu Cys Ser Val Thr Tyr Leu Phe Lys Asn Met Leu Pro Lys Val 
            820                 825                 830         


Ile Asp Glu Leu Asn Lys Phe Asp Leu Arg Thr Lys Thr Glu Leu Ile 
        835                 840                 845             


Asn Leu Ile Asp Ser His Asn Ile Ile Leu Val Gly Glu Val Asp Arg 
    850                 855                 860                 


Leu Lys Ala Lys Val Asn Glu Ser Phe Glu Asn Thr Met Pro Phe Asn 
865                 870                 875                 880 


Ile Phe Ser Tyr Thr Asn Asn Ser Leu Leu Lys Asp Ile Ile Asn Glu 
                885                 890                 895     


Tyr Phe Asn Leu Glu Cys Gly Gly Gly Gly Ser Ile Glu Gly Arg Gln 
            900                 905                 910         


His Trp Ser Tyr Cys Leu Arg Pro Gly 
        915                 920     


<210>  3
<211>  2739
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  3
atgcatcacc atcaccatca ccatcaccat catgggagct cgaacaataa caacaataac       60

aataacaata acggatccat ggagttcgtt aacaaacagt tcaactataa agacccagtt      120

aacggtgttg acattgctta catcaaaatc ccgaacgctg gccagatgca gccggtaaag      180

gcattcaaaa tccacaacaa aatctgggtt atcccggaac gtgatacctt tactaacccg      240

gaagaaggtg acctgaaccc gccaccggaa gcgaaacagg tgccggtatc ttactatgac      300

tccacctacc tgtctaccga taacgaaaag gacaactacc tgaaaggtgt tactaaactg      360

ttcgagcgta tttactccac cgacctgggc cgtatgctgc tgactagcat cgttcgcggt      420

atcccgttct ggggcggttc taccatcgat accgaactga aagtaatcga cactaactgc      480

atcaacgtta ttcagccgga cggttcctat cgttccgaag aactgaacct ggtgatcatc      540

ggcccgtctg ctgatatcat ccagttcgag tgtaagagct ttggtcacga agttctgaac      600

ctcacccgta acggctacgg ttccactcag tacatccgtt tctctccgga cttcaccttc      660

ggttttgaag aatccctgga agtagacacg aacccactgc tgggcgctgg taaattcgca      720

actgatcctg cggttaccct ggctcacgaa ctgattcatg caggccaccg cctgtacggt      780

atcgccatca atccgaaccg tgtcttcaaa gttaacacca acgcgtatta cgagatgtcc      840

ggtctggaag ttagcttcga agaactgcgt acttttggcg gtcacgacgc taaattcatc      900

gactctctgc aagaaaacga gttccgtctg tactactata acaagttcaa agatatcgca      960

tccaccctga acaaagcgaa atccatcgtg ggtaccactg cttctctcca gtacatgaag     1020

aacgttttta aagaaaaata cctgctcagc gaagacacct ccggcaaatt ctctgtagac     1080

aagttgaaat tcgataaact ttacaaaatg ctgactgaaa tttacaccga agacaacttc     1140

gttaagttct ttaaagttct gaaccgcaaa acctatctga acttcgacaa ggcagtattc     1200

aaaatcaaca tcgtgccgaa agttaactac actatctacg atggtttcaa cctgcgtaac     1260

accaacctgg ctgctaattt taacggccag aacacggaaa tcaacaacat gaacttcaca     1320

aaactgaaaa acttcactgg tctgttcgag ttttacaagc tgctgtgcgt cgacggcatc     1380

attacctcca aaactaaatc tctgatagaa ggtagaaaca aagcgctgaa cgacctctgt     1440

atcaaggtta acaactggga tttattcttc agcccgagtg aagacaactt caccaacgac     1500

ctgaacaaag gtgaagaaat cacctcagat actaacatcg aagcagccga agaaaacatc     1560

tcgctggacc tgatccagca gtactacctg acctttaatt tcgacaacga gccggaaaac     1620

atttctatcg aaaacctgag ctctgatatc atcggccagc tggaactgat gccgaacatc     1680

gaacgtttcc caaacggtaa aaagtacgag ctggacaaat ataccatgtt ccactacctg     1740

cgcgcgcagg aatttgaaca cggcaaatcc cgtatcgcac tgactaactc cgttaacgaa     1800

gctctgctca acccgtcccg tgtatacacc ttcttctcta gcgactacgt gaaaaaggtc     1860

aacaaagcga ctgaagctgc aatgttcttg ggttgggttg aacagcttgt ttatgatttt     1920

accgacgaga cgtccgaagt atctactacc gacaaaattg cggatatcac tatcatcatc     1980

ccgtacatcg gtccggctct gaacattggc aacatgctgt acaaagacga cttcgttggc     2040

gcactgatct tctccggtgc ggtgatcctg ctggagttca tcccggaaat cgccatcccg     2100

gtactgggca cctttgctct ggtttcttac attgcaaaca aggttctgac tgtacaaacc     2160

atcgacaacg cgctgagcaa acgtaacgaa aaatgggatg aagtttacaa atatatcgtg     2220

accaactggc tggctaaggt taatactcag atcgacctca tccgcaaaaa aatgaaagaa     2280

gcactggaaa accaggcgga agctaccaag gcaatcatta actaccagta caaccagtac     2340

accgaggaag aaaaaaacaa catcaacttc aacatcgacg atctgtcctc taaactgaac     2400

gaatccatca acaaagctat gatcaacatc aacaagttcc tgaaccagtg ctctgtaagc     2460

tatctgatga actccatgat cccgtacggt gttaaacgtc tggaggactt cgatgcgtct     2520

ctgaaagacg ccctgctgaa atacatttac gacaaccgtg gcactctgat cggtcaggtt     2580

gatcgtctga aggacaaagt gaacaatacc ttatcgaccg acatcccttt tcagctcagt     2640

aaatatgtcg ataaccaacg ccttttgtcc acttgtggcg gtggcggtag catcgaaggt     2700

cgtcagcact ggtcctattg cctgcgccct ggttgataa                            2739


<210>  4
<211>  911
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  4

Met His His His His His His His His His His Gly Ser Ser Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Asn Asn Asn Asn Gly Ser Met Glu Phe Val Asn Lys 
            20                  25                  30          


Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp Ile Ala Tyr Ile 
        35                  40                  45              


Lys Ile Pro Asn Ala Gly Gln Met Gln Pro Val Lys Ala Phe Lys Ile 
    50                  55                  60                  


His Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr Phe Thr Asn Pro 
65                  70                  75                  80  


Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys Gln Val Pro Val 
                85                  90                  95      


Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn Glu Lys Asp Asn 
            100                 105                 110         


Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile Tyr Ser Thr Asp 
        115                 120                 125             


Leu Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile Pro Phe Trp 
    130                 135                 140                 


Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp Thr Asn Cys 
145                 150                 155                 160 


Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu Glu Leu Asn 
                165                 170                 175     


Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln Phe Glu Cys Lys 
            180                 185                 190         


Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn Gly Tyr Gly Ser 
        195                 200                 205             


Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu 
    210                 215                 220                 


Ser Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala Gly Lys Phe Ala 
225                 230                 235                 240 


Thr Asp Pro Ala Val Thr Leu Ala His Glu Leu Ile His Ala Gly His 
                245                 250                 255     


Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe Lys Val Asn 
            260                 265                 270         


Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val Ser Phe Glu Glu 
        275                 280                 285             


Leu Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp Ser Leu Gln 
    290                 295                 300                 


Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile Ala 
305                 310                 315                 320 


Ser Thr Leu Asn Lys Ala Lys Ser Ile Val Gly Thr Thr Ala Ser Leu 
                325                 330                 335     


Gln Tyr Met Lys Asn Val Phe Lys Glu Lys Tyr Leu Leu Ser Glu Asp 
            340                 345                 350         


Thr Ser Gly Lys Phe Ser Val Asp Lys Leu Lys Phe Asp Lys Leu Tyr 
        355                 360                 365             


Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val Lys Phe Phe 
    370                 375                 380                 


Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn Phe Asp Lys Ala Val Phe 
385                 390                 395                 400 


Lys Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr Asp Gly Phe 
                405                 410                 415     


Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr 
            420                 425                 430         


Glu Ile Asn Asn Met Asn Phe Thr Lys Leu Lys Asn Phe Thr Gly Leu 
        435                 440                 445             


Phe Glu Phe Tyr Lys Leu Leu Cys Val Asp Gly Ile Ile Thr Ser Lys 
    450                 455                 460                 


Thr Lys Ser Leu Ile Glu Gly Arg Asn Lys Ala Leu Asn Asp Leu Cys 
465                 470                 475                 480 


Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn 
                485                 490                 495     


Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr Asn 
            500                 505                 510         


Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln Tyr 
        515                 520                 525             


Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu 
    530                 535                 540                 


Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile 
545                 550                 555                 560 


Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met 
                565                 570                 575     


Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile 
            580                 585                 590         


Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser Arg Val 
        595                 600                 605             


Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn Lys Ala Thr 
    610                 615                 620                 


Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr Asp Phe 
625                 630                 635                 640 


Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala Asp Ile 
                645                 650                 655     


Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met 
            660                 665                 670         


Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala Val 
        675                 680                 685             


Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr 
    690                 695                 700                 


Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu Thr Val Gln Thr 
705                 710                 715                 720 


Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu Val Tyr 
                725                 730                 735     


Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr Gln Ile Asp 
            740                 745                 750         


Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala Glu Ala 
        755                 760                 765             


Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu 
    770                 775                 780                 


Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu Asn 
785                 790                 795                 800 


Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln 
                805                 810                 815     


Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly Val Lys 
            820                 825                 830         


Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys Tyr 
        835                 840                 845             


Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp Arg Leu Lys 
    850                 855                 860                 


Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser 
865                 870                 875                 880 


Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Cys Gly Gly Gly Gly 
                885                 890                 895     


Ser Ile Glu Gly Arg Gln His Trp Ser Tyr Cys Leu Arg Pro Gly 
            900                 905                 910     


<210>  5
<211>  2772
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  5
atgcatcacc atcaccatca ccatcaccat catgggagct cgaacaataa caacaataac       60

aataacaata acggatccat gacgtggcca gttaaggatt tcaactactc agatcctgta      120

aatgacaacg atattctgta ccttcgcatt ccacaaaata aactgatcac cacaccagtc      180

aaagcattca tgattactca aaacatttgg gtcattccag aacgcttttc tagtgacaca      240

aatccgagtt tatctaaacc tccgcgtccg acgtccaaat atcagagcta ttacgatccc      300

tcatatctca gtacggacga acaaaaagat actttcctta aaggtatcat taaactgttt      360

aagcgtatta atgagcgcga tatcgggaaa aagttgatta attatcttgt tgtgggttcc      420

ccgttcatgg gcgatagctc tacccccgaa gacacttttg attttacccg tcatacgaca      480

aacatcgcgg tagagaagtt tgagaacgga tcgtggaaag tcacaaacat cattacacct      540

agcgtcttaa tttttggtcc gctgccaaac atcttagatt atacagccag cctgactttg      600

caggggcaac agtcgaatcc gagtttcgaa ggttttggta ccctgagcat tctgaaagtt      660

gccccggaat ttctgctcac tttttcagat gtcaccagca accagagctc agcagtatta      720

ggaaagtcaa ttttttgcat ggacccggtt attgcactga tgcacgaact gacgcactct      780

ctgcatcaac tgtatgggat caacatcccc agtgacaaac gtattcgtcc ccaggtgtct      840

gaaggatttt tctcacagga tgggccgaac gtccagttcg aagagttgta tactttcgga      900

ggcctggacg tagagatcat tccccagatt gagcgcagtc agctgcgtga gaaggcattg      960

ggccattata aggatattgc aaaacgcctg aataacatta acaaaacgat tccatcttcg     1020

tggatctcga atattgataa atataagaaa atttttagcg agaaatataa ttttgataaa     1080

gataatacag gtaactttgt ggttaacatt gacaaattca actcccttta cagtgatttg     1140

acgaatgtaa tgagcgaagt tgtgtatagt tcccaataca acgttaagaa tcgtacccat     1200

tacttctctc gtcactacct gccggttttc gcgaacatcc ttgacgataa tatttacact     1260

attcgtgacg gctttaactt gaccaacaag ggcttcaata ttgaaaattc aggccagaac     1320

attgaacgca acccggcctt gcagaaactg tcgagtgaat ccgtggttga cctgtttacc     1380

aaagtctgcg tcgacggcat cattacctcc aaaactaaat ctctgataga aggtagaaac     1440

aaagcgctga acctgcagtg tattaaagtg aaaaacaatc ggctgcctta tgtagcagat     1500

aaagatagca ttagtcagga gattttcgaa aataaaatta tcactgacga aaccaatgtt     1560

cagaattatt cagataaatt ttcactggac gaaagcatct tagatggcca agttccgatt     1620

aacccggaaa ttgttgatcc gttactgccg aacgtgaata tggaaccgtt aaacctccct     1680

ggcgaagaga tcgtatttta tgatgacatt acgaaatatg tggactacct taattcttat     1740

tactatttgg aaagccagaa actgtccaat aacgtggaaa acattactct gaccacaagc     1800

gtggaagagg ctttaggcta ctcaaataag atttatacct tcctcccgtc gctggcggaa     1860

aaagtaaata aaggtgtgca ggctggtctg ttcctcaact gggcgaatga agttgtcgaa     1920

gactttacca cgaatattat gaaaaaggat accctggata aaatctccga cgtctcggtt     1980

attatcccat atattggccc tgcgttaaat atcggtaata gtgcgctgcg ggggaatttt     2040

aaccaggcct ttgctaccgc gggcgtcgcg ttcctcctgg agggctttcc tgaatttact     2100

atcccggcgc tcggtgtttt tacattttac tcttccatcc aggagcgtga gaaaattatc     2160

aaaaccatcg aaaactgcct ggagcagcgg gtgaaacgct ggaaagattc ttatcaatgg     2220

atggtgtcaa actggttatc tcgcatcacg acccaattca accatattaa ttaccagatg     2280

tatgatagtc tgtcgtacca agctgacgcc attaaagcca aaattgatct ggaatataaa     2340

aagtactctg gtagcgataa ggagaacatc aaaagccagg tggagaacct taagaatagt     2400

ctggatgtga aaatctctga agctatgaat aacattaaca aattcattcg tgaatgttcg     2460

gtgacgtacc tgttcaagaa tatgctgcca aaagttattg atgaactgaa taaatttgat     2520

ctgcgtacca aaaccgaact tatcaacctc atcgactccc acaacattat ccttgtgggc     2580

gaagtggatc gtctgaaggc caaagtaaac gagagctttg aaaatacgat gccgtttaat     2640

attttttcat ataccaataa ctccttgctg aaagatatca tcaatgaata tttcaatcta     2700

gaatgtggcg gtggcggtag cgacgatgac gataaacagc actggtccta ttgcctgcgc     2760

cctggttgat aa                                                         2772


<210>  6
<211>  922
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  6

Met His His His His His His His His His His Gly Ser Ser Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Asn Asn Asn Asn Gly Ser Met Thr Trp Pro Val Lys 
            20                  25                  30          


Asp Phe Asn Tyr Ser Asp Pro Val Asn Asp Asn Asp Ile Leu Tyr Leu 
        35                  40                  45              


Arg Ile Pro Gln Asn Lys Leu Ile Thr Thr Pro Val Lys Ala Phe Met 
    50                  55                  60                  


Ile Thr Gln Asn Ile Trp Val Ile Pro Glu Arg Phe Ser Ser Asp Thr 
65                  70                  75                  80  


Asn Pro Ser Leu Ser Lys Pro Pro Arg Pro Thr Ser Lys Tyr Gln Ser 
                85                  90                  95      


Tyr Tyr Asp Pro Ser Tyr Leu Ser Thr Asp Glu Gln Lys Asp Thr Phe 
            100                 105                 110         


Leu Lys Gly Ile Ile Lys Leu Phe Lys Arg Ile Asn Glu Arg Asp Ile 
        115                 120                 125             


Gly Lys Lys Leu Ile Asn Tyr Leu Val Val Gly Ser Pro Phe Met Gly 
    130                 135                 140                 


Asp Ser Ser Thr Pro Glu Asp Thr Phe Asp Phe Thr Arg His Thr Thr 
145                 150                 155                 160 


Asn Ile Ala Val Glu Lys Phe Glu Asn Gly Ser Trp Lys Val Thr Asn 
                165                 170                 175     


Ile Ile Thr Pro Ser Val Leu Ile Phe Gly Pro Leu Pro Asn Ile Leu 
            180                 185                 190         


Asp Tyr Thr Ala Ser Leu Thr Leu Gln Gly Gln Gln Ser Asn Pro Ser 
        195                 200                 205             


Phe Glu Gly Phe Gly Thr Leu Ser Ile Leu Lys Val Ala Pro Glu Phe 
    210                 215                 220                 


Leu Leu Thr Phe Ser Asp Val Thr Ser Asn Gln Ser Ser Ala Val Leu 
225                 230                 235                 240 


Gly Lys Ser Ile Phe Cys Met Asp Pro Val Ile Ala Leu Met His Glu 
                245                 250                 255     


Leu Thr His Ser Leu His Gln Leu Tyr Gly Ile Asn Ile Pro Ser Asp 
            260                 265                 270         


Lys Arg Ile Arg Pro Gln Val Ser Glu Gly Phe Phe Ser Gln Asp Gly 
        275                 280                 285             


Pro Asn Val Gln Phe Glu Glu Leu Tyr Thr Phe Gly Gly Leu Asp Val 
    290                 295                 300                 


Glu Ile Ile Pro Gln Ile Glu Arg Ser Gln Leu Arg Glu Lys Ala Leu 
305                 310                 315                 320 


Gly His Tyr Lys Asp Ile Ala Lys Arg Leu Asn Asn Ile Asn Lys Thr 
                325                 330                 335     


Ile Pro Ser Ser Trp Ile Ser Asn Ile Asp Lys Tyr Lys Lys Ile Phe 
            340                 345                 350         


Ser Glu Lys Tyr Asn Phe Asp Lys Asp Asn Thr Gly Asn Phe Val Val 
        355                 360                 365             


Asn Ile Asp Lys Phe Asn Ser Leu Tyr Ser Asp Leu Thr Asn Val Met 
    370                 375                 380                 


Ser Glu Val Val Tyr Ser Ser Gln Tyr Asn Val Lys Asn Arg Thr His 
385                 390                 395                 400 


Tyr Phe Ser Arg His Tyr Leu Pro Val Phe Ala Asn Ile Leu Asp Asp 
                405                 410                 415     


Asn Ile Tyr Thr Ile Arg Asp Gly Phe Asn Leu Thr Asn Lys Gly Phe 
            420                 425                 430         


Asn Ile Glu Asn Ser Gly Gln Asn Ile Glu Arg Asn Pro Ala Leu Gln 
        435                 440                 445             


Lys Leu Ser Ser Glu Ser Val Val Asp Leu Phe Thr Lys Val Cys Val 
    450                 455                 460                 


Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu Gly Arg Asn 
465                 470                 475                 480 


Lys Ala Leu Asn Leu Gln Cys Ile Lys Val Lys Asn Asn Arg Leu Pro 
                485                 490                 495     


Tyr Val Ala Asp Lys Asp Ser Ile Ser Gln Glu Ile Phe Glu Asn Lys 
            500                 505                 510         


Ile Ile Thr Asp Glu Thr Asn Val Gln Asn Tyr Ser Asp Lys Phe Ser 
        515                 520                 525             


Leu Asp Glu Ser Ile Leu Asp Gly Gln Val Pro Ile Asn Pro Glu Ile 
    530                 535                 540                 


Val Asp Pro Leu Leu Pro Asn Val Asn Met Glu Pro Leu Asn Leu Pro 
545                 550                 555                 560 


Gly Glu Glu Ile Val Phe Tyr Asp Asp Ile Thr Lys Tyr Val Asp Tyr 
                565                 570                 575     


Leu Asn Ser Tyr Tyr Tyr Leu Glu Ser Gln Lys Leu Ser Asn Asn Val 
            580                 585                 590         


Glu Asn Ile Thr Leu Thr Thr Ser Val Glu Glu Ala Leu Gly Tyr Ser 
        595                 600                 605             


Asn Lys Ile Tyr Thr Phe Leu Pro Ser Leu Ala Glu Lys Val Asn Lys 
    610                 615                 620                 


Gly Val Gln Ala Gly Leu Phe Leu Asn Trp Ala Asn Glu Val Val Glu 
625                 630                 635                 640 


Asp Phe Thr Thr Asn Ile Met Lys Lys Asp Thr Leu Asp Lys Ile Ser 
                645                 650                 655     


Asp Val Ser Val Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly 
            660                 665                 670         


Asn Ser Ala Leu Arg Gly Asn Phe Asn Gln Ala Phe Ala Thr Ala Gly 
        675                 680                 685             


Val Ala Phe Leu Leu Glu Gly Phe Pro Glu Phe Thr Ile Pro Ala Leu 
    690                 695                 700                 


Gly Val Phe Thr Phe Tyr Ser Ser Ile Gln Glu Arg Glu Lys Ile Ile 
705                 710                 715                 720 


Lys Thr Ile Glu Asn Cys Leu Glu Gln Arg Val Lys Arg Trp Lys Asp 
                725                 730                 735     


Ser Tyr Gln Trp Met Val Ser Asn Trp Leu Ser Arg Ile Thr Thr Gln 
            740                 745                 750         


Phe Asn His Ile Asn Tyr Gln Met Tyr Asp Ser Leu Ser Tyr Gln Ala 
        755                 760                 765             


Asp Ala Ile Lys Ala Lys Ile Asp Leu Glu Tyr Lys Lys Tyr Ser Gly 
    770                 775                 780                 


Ser Asp Lys Glu Asn Ile Lys Ser Gln Val Glu Asn Leu Lys Asn Ser 
785                 790                 795                 800 


Leu Asp Val Lys Ile Ser Glu Ala Met Asn Asn Ile Asn Lys Phe Ile 
                805                 810                 815     


Arg Glu Cys Ser Val Thr Tyr Leu Phe Lys Asn Met Leu Pro Lys Val 
            820                 825                 830         


Ile Asp Glu Leu Asn Lys Phe Asp Leu Arg Thr Lys Thr Glu Leu Ile 
        835                 840                 845             


Asn Leu Ile Asp Ser His Asn Ile Ile Leu Val Gly Glu Val Asp Arg 
    850                 855                 860                 


Leu Lys Ala Lys Val Asn Glu Ser Phe Glu Asn Thr Met Pro Phe Asn 
865                 870                 875                 880 


Ile Phe Ser Tyr Thr Asn Asn Ser Leu Leu Lys Asp Ile Ile Asn Glu 
                885                 890                 895     


Tyr Phe Asn Leu Glu Cys Gly Gly Gly Gly Ser Asp Asp Asp Asp Lys 
            900                 905                 910         


Gln His Trp Ser Tyr Cys Leu Arg Pro Gly 
        915                 920         


<210>  7
<211>  2850
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  7
atgcatcacc atcaccatca ccatcaccat catgggagct cgaacaataa caacaataac       60

aataacaata acggatccat gacgtggcca gttaaggatt tcaactactc agatcctgta      120

aatgacaacg atattctgta ccttcgcatt ccacaaaata aactgatcac cacaccagtc      180

aaagcattca tgattactca aaacatttgg gtcattccag aacgcttttc tagtgacaca      240

aatccgagtt tatctaaacc tccgcgtccg acgtccaaat atcagagcta ttacgatccc      300

tcatatctca gtacggacga acaaaaagat actttcctta aaggtatcat taaactgttt      360

aagcgtatta atgagcgcga tatcgggaaa aagttgatta attatcttgt tgtgggttcc      420

ccgttcatgg gcgatagctc tacccccgaa gacacttttg attttacccg tcatacgaca      480

aacatcgcgg tagagaagtt tgagaacgga tcgtggaaag tcacaaacat cattacacct      540

agcgtcttaa tttttggtcc gctgccaaac atcttagatt atacagccag cctgactttg      600

caggggcaac agtcgaatcc gagtttcgaa ggttttggta ccctgagcat tctgaaagtt      660

gccccggaat ttctgctcac tttttcagat gtcaccagca accagagctc agcagtatta      720

ggaaagtcaa ttttttgcat ggacccggtt attgcactga tgcacgaact gacgcactct      780

ctgcatcaac tgtatgggat caacatcccc agtgacaaac gtattcgtcc ccaggtgtct      840

gaaggatttt tctcacagga tgggccgaac gtccagttcg aagagttgta tactttcgga      900

ggcctggacg tagagatcat tccccagatt gagcgcagtc agctgcgtga gaaggcattg      960

ggccattata aggatattgc aaaacgcctg aataacatta acaaaacgat tccatcttcg     1020

tggatctcga atattgataa atataagaaa atttttagcg agaaatataa ttttgataaa     1080

gataatacag gtaactttgt ggttaacatt gacaaattca actcccttta cagtgatttg     1140

acgaatgtaa tgagcgaagt tgtgtatagt tcccaataca acgttaagaa tcgtacccat     1200

tacttctctc gtcactacct gccggttttc gcgaacatcc ttgacgataa tatttacact     1260

attcgtgacg gctttaactt gaccaacaag ggcttcaata ttgaaaattc aggccagaac     1320

attgaacgca acccggcctt gcagaaactg tcgagtgaat ccgtggttga cctgtttacc     1380

aaagtctgcg tcgacggcat cattacctcc aaaactaaat ctctgataga aggtagaaac     1440

aaagcgctga acctgcagtg tattaaagtg aaaaacaatc ggctgcctta tgtagcagat     1500

aaagatagca ttagtcagga gattttcgaa aataaaatta tcactgacga aaccaatgtt     1560

cagaattatt cagataaatt ttcactggac gaaagcatct tagatggcca agttccgatt     1620

aacccggaaa ttgttgatcc gttactgccg aacgtgaata tggaaccgtt aaacctccct     1680

ggcgaagaga tcgtatttta tgatgacatt acgaaatatg tggactacct taattcttat     1740

tactatttgg aaagccagaa actgtccaat aacgtggaaa acattactct gaccacaagc     1800

gtggaagagg ctttaggcta ctcaaataag atttatacct tcctcccgtc gctggcggaa     1860

aaagtaaata aaggtgtgca ggctggtctg ttcctcaact gggcgaatga agttgtcgaa     1920

gactttacca cgaatattat gaaaaaggat accctggata aaatctccga cgtctcggtt     1980

attatcccat atattggccc tgcgttaaat atcggtaata gtgcgctgcg ggggaatttt     2040

aaccaggcct ttgctaccgc gggcgtcgcg ttcctcctgg agggctttcc tgaatttact     2100

atcccggcgc tcggtgtttt tacattttac tcttccatcc aggagcgtga gaaaattatc     2160

aaaaccatcg aaaactgcct ggagcagcgg gtgaaacgct ggaaagattc ttatcaatgg     2220

atggtgtcaa actggttatc tcgcatcacg acccaattca accatattaa ttaccagatg     2280

tatgatagtc tgtcgtacca agctgacgcc attaaagcca aaattgatct ggaatataaa     2340

aagtactctg gtagcgataa ggagaacatc aaaagccagg tggagaacct taagaatagt     2400

ctggatgtga aaatctctga agctatgaat aacattaaca aattcattcg tgaatgttcg     2460

gtgacgtacc tgttcaagaa tatgctgcca aaagttattg atgaactgaa taaatttgat     2520

ctgcgtacca aaaccgaact tatcaacctc atcgactccc acaacattat ccttgtgggc     2580

gaagtggatc gtctgaaggc caaagtaaac gagagctttg aaaatacgat gccgtttaat     2640

attttttcat ataccaataa ctccttgctg aaagatatca tcaatgaata tttcaatcta     2700

gaatgtggcg gtggcggtag catcgaaggt cgttatggag gttttttgag aaggatacga     2760

ccaaaattaa agtgggataa tcaaggcggt gggggtagtt gcggcggtgg cggttcgcgt     2820

ccgccgggtt tctctccgtt ccgttgataa                                      2850


<210>  8
<211>  948
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  8

Met His His His His His His His His His His Gly Ser Ser Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Asn Asn Asn Asn Gly Ser Met Thr Trp Pro Val Lys 
            20                  25                  30          


Asp Phe Asn Tyr Ser Asp Pro Val Asn Asp Asn Asp Ile Leu Tyr Leu 
        35                  40                  45              


Arg Ile Pro Gln Asn Lys Leu Ile Thr Thr Pro Val Lys Ala Phe Met 
    50                  55                  60                  


Ile Thr Gln Asn Ile Trp Val Ile Pro Glu Arg Phe Ser Ser Asp Thr 
65                  70                  75                  80  


Asn Pro Ser Leu Ser Lys Pro Pro Arg Pro Thr Ser Lys Tyr Gln Ser 
                85                  90                  95      


Tyr Tyr Asp Pro Ser Tyr Leu Ser Thr Asp Glu Gln Lys Asp Thr Phe 
            100                 105                 110         


Leu Lys Gly Ile Ile Lys Leu Phe Lys Arg Ile Asn Glu Arg Asp Ile 
        115                 120                 125             


Gly Lys Lys Leu Ile Asn Tyr Leu Val Val Gly Ser Pro Phe Met Gly 
    130                 135                 140                 


Asp Ser Ser Thr Pro Glu Asp Thr Phe Asp Phe Thr Arg His Thr Thr 
145                 150                 155                 160 


Asn Ile Ala Val Glu Lys Phe Glu Asn Gly Ser Trp Lys Val Thr Asn 
                165                 170                 175     


Ile Ile Thr Pro Ser Val Leu Ile Phe Gly Pro Leu Pro Asn Ile Leu 
            180                 185                 190         


Asp Tyr Thr Ala Ser Leu Thr Leu Gln Gly Gln Gln Ser Asn Pro Ser 
        195                 200                 205             


Phe Glu Gly Phe Gly Thr Leu Ser Ile Leu Lys Val Ala Pro Glu Phe 
    210                 215                 220                 


Leu Leu Thr Phe Ser Asp Val Thr Ser Asn Gln Ser Ser Ala Val Leu 
225                 230                 235                 240 


Gly Lys Ser Ile Phe Cys Met Asp Pro Val Ile Ala Leu Met His Glu 
                245                 250                 255     


Leu Thr His Ser Leu His Gln Leu Tyr Gly Ile Asn Ile Pro Ser Asp 
            260                 265                 270         


Lys Arg Ile Arg Pro Gln Val Ser Glu Gly Phe Phe Ser Gln Asp Gly 
        275                 280                 285             


Pro Asn Val Gln Phe Glu Glu Leu Tyr Thr Phe Gly Gly Leu Asp Val 
    290                 295                 300                 


Glu Ile Ile Pro Gln Ile Glu Arg Ser Gln Leu Arg Glu Lys Ala Leu 
305                 310                 315                 320 


Gly His Tyr Lys Asp Ile Ala Lys Arg Leu Asn Asn Ile Asn Lys Thr 
                325                 330                 335     


Ile Pro Ser Ser Trp Ile Ser Asn Ile Asp Lys Tyr Lys Lys Ile Phe 
            340                 345                 350         


Ser Glu Lys Tyr Asn Phe Asp Lys Asp Asn Thr Gly Asn Phe Val Val 
        355                 360                 365             


Asn Ile Asp Lys Phe Asn Ser Leu Tyr Ser Asp Leu Thr Asn Val Met 
    370                 375                 380                 


Ser Glu Val Val Tyr Ser Ser Gln Tyr Asn Val Lys Asn Arg Thr His 
385                 390                 395                 400 


Tyr Phe Ser Arg His Tyr Leu Pro Val Phe Ala Asn Ile Leu Asp Asp 
                405                 410                 415     


Asn Ile Tyr Thr Ile Arg Asp Gly Phe Asn Leu Thr Asn Lys Gly Phe 
            420                 425                 430         


Asn Ile Glu Asn Ser Gly Gln Asn Ile Glu Arg Asn Pro Ala Leu Gln 
        435                 440                 445             


Lys Leu Ser Ser Glu Ser Val Val Asp Leu Phe Thr Lys Val Cys Val 
    450                 455                 460                 


Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu Gly Arg Asn 
465                 470                 475                 480 


Lys Ala Leu Asn Leu Gln Cys Ile Lys Val Lys Asn Asn Arg Leu Pro 
                485                 490                 495     


Tyr Val Ala Asp Lys Asp Ser Ile Ser Gln Glu Ile Phe Glu Asn Lys 
            500                 505                 510         


Ile Ile Thr Asp Glu Thr Asn Val Gln Asn Tyr Ser Asp Lys Phe Ser 
        515                 520                 525             


Leu Asp Glu Ser Ile Leu Asp Gly Gln Val Pro Ile Asn Pro Glu Ile 
    530                 535                 540                 


Val Asp Pro Leu Leu Pro Asn Val Asn Met Glu Pro Leu Asn Leu Pro 
545                 550                 555                 560 


Gly Glu Glu Ile Val Phe Tyr Asp Asp Ile Thr Lys Tyr Val Asp Tyr 
                565                 570                 575     


Leu Asn Ser Tyr Tyr Tyr Leu Glu Ser Gln Lys Leu Ser Asn Asn Val 
            580                 585                 590         


Glu Asn Ile Thr Leu Thr Thr Ser Val Glu Glu Ala Leu Gly Tyr Ser 
        595                 600                 605             


Asn Lys Ile Tyr Thr Phe Leu Pro Ser Leu Ala Glu Lys Val Asn Lys 
    610                 615                 620                 


Gly Val Gln Ala Gly Leu Phe Leu Asn Trp Ala Asn Glu Val Val Glu 
625                 630                 635                 640 


Asp Phe Thr Thr Asn Ile Met Lys Lys Asp Thr Leu Asp Lys Ile Ser 
                645                 650                 655     


Asp Val Ser Val Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly 
            660                 665                 670         


Asn Ser Ala Leu Arg Gly Asn Phe Asn Gln Ala Phe Ala Thr Ala Gly 
        675                 680                 685             


Val Ala Phe Leu Leu Glu Gly Phe Pro Glu Phe Thr Ile Pro Ala Leu 
    690                 695                 700                 


Gly Val Phe Thr Phe Tyr Ser Ser Ile Gln Glu Arg Glu Lys Ile Ile 
705                 710                 715                 720 


Lys Thr Ile Glu Asn Cys Leu Glu Gln Arg Val Lys Arg Trp Lys Asp 
                725                 730                 735     


Ser Tyr Gln Trp Met Val Ser Asn Trp Leu Ser Arg Ile Thr Thr Gln 
            740                 745                 750         


Phe Asn His Ile Asn Tyr Gln Met Tyr Asp Ser Leu Ser Tyr Gln Ala 
        755                 760                 765             


Asp Ala Ile Lys Ala Lys Ile Asp Leu Glu Tyr Lys Lys Tyr Ser Gly 
    770                 775                 780                 


Ser Asp Lys Glu Asn Ile Lys Ser Gln Val Glu Asn Leu Lys Asn Ser 
785                 790                 795                 800 


Leu Asp Val Lys Ile Ser Glu Ala Met Asn Asn Ile Asn Lys Phe Ile 
                805                 810                 815     


Arg Glu Cys Ser Val Thr Tyr Leu Phe Lys Asn Met Leu Pro Lys Val 
            820                 825                 830         


Ile Asp Glu Leu Asn Lys Phe Asp Leu Arg Thr Lys Thr Glu Leu Ile 
        835                 840                 845             


Asn Leu Ile Asp Ser His Asn Ile Ile Leu Val Gly Glu Val Asp Arg 
    850                 855                 860                 


Leu Lys Ala Lys Val Asn Glu Ser Phe Glu Asn Thr Met Pro Phe Asn 
865                 870                 875                 880 


Ile Phe Ser Tyr Thr Asn Asn Ser Leu Leu Lys Asp Ile Ile Asn Glu 
                885                 890                 895     


Tyr Phe Asn Leu Glu Cys Gly Gly Gly Gly Ser Ile Glu Gly Arg Tyr 
            900                 905                 910         


Gly Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn Gln 
        915                 920                 925             


Gly Gly Gly Gly Ser Cys Gly Gly Gly Gly Ser Arg Pro Pro Gly Phe 
    930                 935                 940                 


Ser Pro Phe Arg 
945             


<210>  9
<211>  2862
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  9
atgcatcacc atcaccatca ccatcaccat catgggagct cgaacaataa caacaataac       60

aataacaata acggatccat ggagttcgtt aacaaacagt tcaactataa agacccagtt      120

aacggtgttg acattgctta catcaaaatc ccgaacgctg gccagatgca gccggtaaag      180

gcattcaaaa tccacaacaa aatctgggtt atcccggaac gtgatacctt tactaacccg      240

gaagaaggtg acctgaaccc gccaccggaa gcgaaacagg tgccggtatc ttactatgac      300

tccacctacc tgtctaccga taacgaaaag gacaactacc tgaaaggtgt tactaaactg      360

ttcgagcgta tttactccac cgacctgggc cgtatgctgc tgactagcat cgttcgcggt      420

atcccgttct ggggcggttc taccatcgat accgaactga aagtaatcga cactaactgc      480

atcaacgtta ttcagccgga cggttcctat cgttccgaag aactgaacct ggtgatcatc      540

ggcccgtctg ctgatatcat ccagttcgag tgtaagagct ttggtcacga agttctgaac      600

ctcacccgta acggctacgg ttccactcag tacatccgtt tctctccgga cttcaccttc      660

ggttttgaag aatccctgga agtagacacg aacccactgc tgggcgctgg taaattcgca      720

actgatcctg cggttaccct ggctcacgaa ctgattcatg caggccaccg cctgtacggt      780

atcgccatca atccgaaccg tgtcttcaaa gttaacacca acgcgtatta cgagatgtcc      840

ggtctggaag ttagcttcga agaactgcgt acttttggcg gtcacgacgc taaattcatc      900

gactctctgc aagaaaacga gttccgtctg tactactata acaagttcaa agatatcgca      960

tccaccctga acaaagcgaa atccatcgtg ggtaccactg cttctctcca gtacatgaag     1020

aacgttttta aagaaaaata cctgctcagc gaagacacct ccggcaaatt ctctgtagac     1080

aagttgaaat tcgataaact ttacaaaatg ctgactgaaa tttacaccga agacaacttc     1140

gttaagttct ttaaagttct gaaccgcaaa acctatctga acttcgacaa ggcagtattc     1200

aaaatcaaca tcgtgccgaa agttaactac actatctacg atggtttcaa cctgcgtaac     1260

accaacctgg ctgctaattt taacggccag aacacggaaa tcaacaacat gaacttcaca     1320

aaactgaaaa acttcactgg tctgttcgag ttttacaagc tgctgtgcgt cgacggcatc     1380

attacctcca aaactaaatc tctgatagaa ggtagaaaca aagcgctgaa cgacctctgt     1440

atcaaggtta acaactggga tttattcttc agcccgagtg aagacaactt caccaacgac     1500

ctgaacaaag gtgaagaaat cacctcagat actaacatcg aagcagccga agaaaacatc     1560

tcgctggacc tgatccagca gtactacctg acctttaatt tcgacaacga gccggaaaac     1620

atttctatcg aaaacctgag ctctgatatc atcggccagc tggaactgat gccgaacatc     1680

gaacgtttcc caaacggtaa aaagtacgag ctggacaaat ataccatgtt ccactacctg     1740

cgcgcgcagg aatttgaaca cggcaaatcc cgtatcgcac tgactaactc cgttaacgaa     1800

gctctgctca acccgtcccg tgtatacacc ttcttctcta gcgactacgt gaaaaaggtc     1860

aacaaagcga ctgaagctgc aatgttcttg ggttgggttg aacagcttgt ttatgatttt     1920

accgacgaga cgtccgaagt atctactacc gacaaaattg cggatatcac tatcatcatc     1980

ccgtacatcg gtccggctct gaacattggc aacatgctgt acaaagacga cttcgttggc     2040

gcactgatct tctccggtgc ggtgatcctg ctggagttca tcccggaaat cgccatcccg     2100

gtactgggca cctttgctct ggtttcttac attgcaaaca aggttctgac tgtacaaacc     2160

atcgacaacg cgctgagcaa acgtaacgaa aaatgggatg aagtttacaa atatatcgtg     2220

accaactggc tggctaaggt taatactcag atcgacctca tccgcaaaaa aatgaaagaa     2280

gcactggaaa accaggcgga agctaccaag gcaatcatta actaccagta caaccagtac     2340

accgaggaag aaaaaaacaa catcaacttc aacatcgacg atctgtcctc taaactgaac     2400

gaatccatca acaaagctat gatcaacatc aacaagttcc tgaaccagtg ctctgtaagc     2460

tatctgatga actccatgat cccgtacggt gttaaacgtc tggaggactt cgatgcgtct     2520

ctgaaagacg ccctgctgaa atacatttac gacaaccgtg gcactctgat cggtcaggtt     2580

gatcgtctga aggacaaagt gaacaatacc ttatcgaccg acatcccttt tcagctcagt     2640

aaatatgtcg ataaccaacg ccttttgtcc acttgtggcg gtggcggtag catcgaaggt     2700

cgttacggtg gtttcatgac ctctgaaaaa tctcagaccc cgctggttac cctgttcaaa     2760

aacgctatca tcaaaaacgc ttacaaaaaa ggtgaaggcg gtgggggtag ttgcggcggt     2820

ggcggttcgc gtccgccggg tttctctccg ttccgttgat aa                        2862


<210>  10
<211>  952
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  10

Met His His His His His His His His His His Gly Ser Ser Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Asn Asn Asn Asn Gly Ser Met Glu Phe Val Asn Lys 
            20                  25                  30          


Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp Ile Ala Tyr Ile 
        35                  40                  45              


Lys Ile Pro Asn Ala Gly Gln Met Gln Pro Val Lys Ala Phe Lys Ile 
    50                  55                  60                  


His Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr Phe Thr Asn Pro 
65                  70                  75                  80  


Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys Gln Val Pro Val 
                85                  90                  95      


Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn Glu Lys Asp Asn 
            100                 105                 110         


Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile Tyr Ser Thr Asp 
        115                 120                 125             


Leu Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile Pro Phe Trp 
    130                 135                 140                 


Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp Thr Asn Cys 
145                 150                 155                 160 


Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu Glu Leu Asn 
                165                 170                 175     


Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln Phe Glu Cys Lys 
            180                 185                 190         


Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn Gly Tyr Gly Ser 
        195                 200                 205             


Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu 
    210                 215                 220                 


Ser Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala Gly Lys Phe Ala 
225                 230                 235                 240 


Thr Asp Pro Ala Val Thr Leu Ala His Glu Leu Ile His Ala Gly His 
                245                 250                 255     


Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe Lys Val Asn 
            260                 265                 270         


Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val Ser Phe Glu Glu 
        275                 280                 285             


Leu Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp Ser Leu Gln 
    290                 295                 300                 


Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile Ala 
305                 310                 315                 320 


Ser Thr Leu Asn Lys Ala Lys Ser Ile Val Gly Thr Thr Ala Ser Leu 
                325                 330                 335     


Gln Tyr Met Lys Asn Val Phe Lys Glu Lys Tyr Leu Leu Ser Glu Asp 
            340                 345                 350         


Thr Ser Gly Lys Phe Ser Val Asp Lys Leu Lys Phe Asp Lys Leu Tyr 
        355                 360                 365             


Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val Lys Phe Phe 
    370                 375                 380                 


Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn Phe Asp Lys Ala Val Phe 
385                 390                 395                 400 


Lys Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr Asp Gly Phe 
                405                 410                 415     


Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr 
            420                 425                 430         


Glu Ile Asn Asn Met Asn Phe Thr Lys Leu Lys Asn Phe Thr Gly Leu 
        435                 440                 445             


Phe Glu Phe Tyr Lys Leu Leu Cys Val Asp Gly Ile Ile Thr Ser Lys 
    450                 455                 460                 


Thr Lys Ser Leu Ile Glu Gly Arg Asn Lys Ala Leu Asn Asp Leu Cys 
465                 470                 475                 480 


Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn 
                485                 490                 495     


Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr Asn 
            500                 505                 510         


Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln Tyr 
        515                 520                 525             


Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu 
    530                 535                 540                 


Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile 
545                 550                 555                 560 


Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met 
                565                 570                 575     


Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile 
            580                 585                 590         


Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser Arg Val 
        595                 600                 605             


Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn Lys Ala Thr 
    610                 615                 620                 


Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr Asp Phe 
625                 630                 635                 640 


Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala Asp Ile 
                645                 650                 655     


Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met 
            660                 665                 670         


Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala Val 
        675                 680                 685             


Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr 
    690                 695                 700                 


Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu Thr Val Gln Thr 
705                 710                 715                 720 


Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu Val Tyr 
                725                 730                 735     


Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr Gln Ile Asp 
            740                 745                 750         


Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala Glu Ala 
        755                 760                 765             


Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu 
    770                 775                 780                 


Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu Asn 
785                 790                 795                 800 


Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln 
                805                 810                 815     


Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly Val Lys 
            820                 825                 830         


Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys Tyr 
        835                 840                 845             


Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp Arg Leu Lys 
    850                 855                 860                 


Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser 
865                 870                 875                 880 


Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Cys Gly Gly Gly Gly 
                885                 890                 895     


Ser Ile Glu Gly Arg Tyr Gly Gly Phe Met Thr Ser Glu Lys Ser Gln 
            900                 905                 910         


Thr Pro Leu Val Thr Leu Phe Lys Asn Ala Ile Ile Lys Asn Ala Tyr 
        915                 920                 925             


Lys Lys Gly Glu Gly Gly Gly Gly Ser Cys Gly Gly Gly Gly Ser Arg 
    930                 935                 940                 


Pro Pro Gly Phe Ser Pro Phe Arg 
945                 950         


<210>  11
<211>  3012
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  11
atgcatcacc atcaccatca ccatcaccat catgggagct cgaacaataa caacaataac       60

aataacaata acggatccat gacgtggcca gttaaggatt tcaactactc agatcctgta      120

aatgacaacg atattctgta ccttcgcatt ccacaaaata aactgatcac cacaccagtc      180

aaagcattca tgattactca aaacatttgg gtcattccag aacgcttttc tagtgacaca      240

aatccgagtt tatctaaacc tccgcgtccg acgtccaaat atcagagcta ttacgatccc      300

tcatatctca gtacggacga acaaaaagat actttcctta aaggtatcat taaactgttt      360

aagcgtatta atgagcgcga tatcgggaaa aagttgatta attatcttgt tgtgggttcc      420

ccgttcatgg gcgatagctc tacccccgaa gacacttttg attttacccg tcatacgaca      480

aacatcgcgg tagagaagtt tgagaacgga tcgtggaaag tcacaaacat cattacacct      540

agcgtcttaa tttttggtcc gctgccaaac atcttagatt atacagccag cctgactttg      600

caggggcaac agtcgaatcc gagtttcgaa ggttttggta ccctgagcat tctgaaagtt      660

gccccggaat ttctgctcac tttttcagat gtcaccagca accagagctc agcagtatta      720

ggaaagtcaa ttttttgcat ggacccggtt attgcactga tgcacgaact gacgcactct      780

ctgcatcaac tgtatgggat caacatcccc agtgacaaac gtattcgtcc ccaggtgtct      840

gaaggatttt tctcacagga tgggccgaac gtccagttcg aagagttgta tactttcgga      900

ggcctggacg tagagatcat tccccagatt gagcgcagtc agctgcgtga gaaggcattg      960

ggccattata aggatattgc aaaacgcctg aataacatta acaaaacgat tccatcttcg     1020

tggatctcga atattgataa atataagaaa atttttagcg agaaatataa ttttgataaa     1080

gataatacag gtaactttgt ggttaacatt gacaaattca actcccttta cagtgatttg     1140

acgaatgtaa tgagcgaagt tgtgtatagt tcccaataca acgttaagaa tcgtacccat     1200

tacttctctc gtcactacct gccggttttc gcgaacatcc ttgacgataa tatttacact     1260

attcgtgacg gctttaactt gaccaacaag ggcttcaata ttgaaaattc aggccagaac     1320

attgaacgca acccggcctt gcagaaactg tcgagtgaat ccgtggttga cctgtttacc     1380

aaagtctgcg tcgacggcat cattacctcc aaaactaaat ctctgataga aggtagaaac     1440

aaagcgctga acctgcagtg tattaaagtg aaaaacaatc ggctgcctta tgtagcagat     1500

aaagatagca ttagtcagga gattttcgaa aataaaatta tcactgacga aaccaatgtt     1560

cagaattatt cagataaatt ttcactggac gaaagcatct tagatggcca agttccgatt     1620

aacccggaaa ttgttgatcc gttactgccg aacgtgaata tggaaccgtt aaacctccct     1680

ggcgaagaga tcgtatttta tgatgacatt acgaaatatg tggactacct taattcttat     1740

tactatttgg aaagccagaa actgtccaat aacgtggaaa acattactct gaccacaagc     1800

gtggaagagg ctttaggcta ctcaaataag atttatacct tcctcccgtc gctggcggaa     1860

aaagtaaata aaggtgtgca ggctggtctg ttcctcaact gggcgaatga agttgtcgaa     1920

gactttacca cgaatattat gaaaaaggat accctggata aaatctccga cgtctcggtt     1980

attatcccat atattggccc tgcgttaaat atcggtaata gtgcgctgcg ggggaatttt     2040

aaccaggcct ttgctaccgc gggcgtcgcg ttcctcctgg agggctttcc tgaatttact     2100

atcccggcgc tcggtgtttt tacattttac tcttccatcc aggagcgtga gaaaattatc     2160

aaaaccatcg aaaactgcct ggagcagcgg gtgaaacgct ggaaagattc ttatcaatgg     2220

atggtgtcaa actggttatc tcgcatcacg acccaattca accatattaa ttaccagatg     2280

tatgatagtc tgtcgtacca agctgacgcc attaaagcca aaattgatct ggaatataaa     2340

aagtactctg gtagcgataa ggagaacatc aaaagccagg tggagaacct taagaatagt     2400

ctggatgtga aaatctctga agctatgaat aacattaaca aattcattcg tgaatgttcg     2460

gtgacgtacc tgttcaagaa tatgctgcca aaagttattg atgaactgaa taaatttgat     2520

ctgcgtacca aaaccgaact tatcaacctc atcgactccc acaacattat ccttgtgggc     2580

gaagtggatc gtctgaaggc caaagtaaac gagagctttg aaaatacgat gccgtttaat     2640

attttttcat ataccaataa ctccttgctg aaagatatca tcaatgaata tttcaatcta     2700

gaatgtggcg gtggcggtag catcgaaggt cgtcacgtgg atgcgatctt cactcagtct     2760

taccgtaaag ttctggcgca gctgagcgct cgtaaactgc tgcaggatat cctgaaccgt     2820

cagcagggtg aacgtaacca ggaacagggc gctggcggtg ggggtagttg cggcggtggc     2880

ggttcgcacg tggatgcgat cttcactcag tcttaccgta aagttctggc gcagctgagc     2940

gctcgtaaac tgctgcagga tatcctgaac cgtcagcagg gtgaacgtaa ccaggaacag     3000

ggcgcttgat aa                                                         3012


<210>  12
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  12

Met His His His His His His His His His His Gly Ser Ser Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Asn Asn Asn Asn Gly Ser Met Thr Trp Pro Val Lys 
            20                  25                  30          


Asp Phe Asn Tyr Ser Asp Pro Val Asn Asp Asn Asp Ile Leu Tyr Leu 
        35                  40                  45              


Arg Ile Pro Gln Asn Lys Leu Ile Thr Thr Pro Val Lys Ala Phe Met 
    50                  55                  60                  


Ile Thr Gln Asn Ile Trp Val Ile Pro Glu Arg Phe Ser Ser Asp Thr 
65                  70                  75                  80  


Asn Pro Ser Leu Ser Lys Pro Pro Arg Pro Thr Ser Lys Tyr Gln Ser 
                85                  90                  95      


Tyr Tyr Asp Pro Ser Tyr Leu Ser Thr Asp Glu Gln Lys Asp Thr Phe 
            100                 105                 110         


Leu Lys Gly Ile Ile Lys Leu Phe Lys Arg Ile Asn Glu Arg Asp Ile 
        115                 120                 125             


Gly Lys Lys Leu Ile Asn Tyr Leu Val Val Gly Ser Pro Phe Met Gly 
    130                 135                 140                 


Asp Ser Ser Thr Pro Glu Asp Thr Phe Asp Phe Thr Arg His Thr Thr 
145                 150                 155                 160 


Asn Ile Ala Val Glu Lys Phe Glu Asn Gly Ser Trp Lys Val Thr Asn 
                165                 170                 175     


Ile Ile Thr Pro Ser Val Leu Ile Phe Gly Pro Leu Pro Asn Ile Leu 
            180                 185                 190         


Asp Tyr Thr Ala Ser Leu Thr Leu Gln Gly Gln Gln Ser Asn Pro Ser 
        195                 200                 205             


Phe Glu Gly Phe Gly Thr Leu Ser Ile Leu Lys Val Ala Pro Glu Phe 
    210                 215                 220                 


Leu Leu Thr Phe Ser Asp Val Thr Ser Asn Gln Ser Ser Ala Val Leu 
225                 230                 235                 240 


Gly Lys Ser Ile Phe Cys Met Asp Pro Val Ile Ala Leu Met His Glu 
                245                 250                 255     


Leu Thr His Ser Leu His Gln Leu Tyr Gly Ile Asn Ile Pro Ser Asp 
            260                 265                 270         


Lys Arg Ile Arg Pro Gln Val Ser Glu Gly Phe Phe Ser Gln Asp Gly 
        275                 280                 285             


Pro Asn Val Gln Phe Glu Glu Leu Tyr Thr Phe Gly Gly Leu Asp Val 
    290                 295                 300                 


Glu Ile Ile Pro Gln Ile Glu Arg Ser Gln Leu Arg Glu Lys Ala Leu 
305                 310                 315                 320 


Gly His Tyr Lys Asp Ile Ala Lys Arg Leu Asn Asn Ile Asn Lys Thr 
                325                 330                 335     


Ile Pro Ser Ser Trp Ile Ser Asn Ile Asp Lys Tyr Lys Lys Ile Phe 
            340                 345                 350         


Ser Glu Lys Tyr Asn Phe Asp Lys Asp Asn Thr Gly Asn Phe Val Val 
        355                 360                 365             


Asn Ile Asp Lys Phe Asn Ser Leu Tyr Ser Asp Leu Thr Asn Val Met 
    370                 375                 380                 


Ser Glu Val Val Tyr Ser Ser Gln Tyr Asn Val Lys Asn Arg Thr His 
385                 390                 395                 400 


Tyr Phe Ser Arg His Tyr Leu Pro Val Phe Ala Asn Ile Leu Asp Asp 
                405                 410                 415     


Asn Ile Tyr Thr Ile Arg Asp Gly Phe Asn Leu Thr Asn Lys Gly Phe 
            420                 425                 430         


Asn Ile Glu Asn Ser Gly Gln Asn Ile Glu Arg Asn Pro Ala Leu Gln 
        435                 440                 445             


Lys Leu Ser Ser Glu Ser Val Val Asp Leu Phe Thr Lys Val Cys Val 
    450                 455                 460                 


Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu Gly Arg Asn 
465                 470                 475                 480 


Lys Ala Leu Asn Leu Gln Cys Ile Lys Val Lys Asn Asn Arg Leu Pro 
                485                 490                 495     


Tyr Val Ala Asp Lys Asp Ser Ile Ser Gln Glu Ile Phe Glu Asn Lys 
            500                 505                 510         


Ile Ile Thr Asp Glu Thr Asn Val Gln Asn Tyr Ser Asp Lys Phe Ser 
        515                 520                 525             


Leu Asp Glu Ser Ile Leu Asp Gly Gln Val Pro Ile Asn Pro Glu Ile 
    530                 535                 540                 


Val Asp Pro Leu Leu Pro Asn Val Asn Met Glu Pro Leu Asn Leu Pro 
545                 550                 555                 560 


Gly Glu Glu Ile Val Phe Tyr Asp Asp Ile Thr Lys Tyr Val Asp Tyr 
                565                 570                 575     


Leu Asn Ser Tyr Tyr Tyr Leu Glu Ser Gln Lys Leu Ser Asn Asn Val 
            580                 585                 590         


Glu Asn Ile Thr Leu Thr Thr Ser Val Glu Glu Ala Leu Gly Tyr Ser 
        595                 600                 605             


Asn Lys Ile Tyr Thr Phe Leu Pro Ser Leu Ala Glu Lys Val Asn Lys 
    610                 615                 620                 


Gly Val Gln Ala Gly Leu Phe Leu Asn Trp Ala Asn Glu Val Val Glu 
625                 630                 635                 640 


Asp Phe Thr Thr Asn Ile Met Lys Lys Asp Thr Leu Asp Lys Ile Ser 
                645                 650                 655     


Asp Val Ser Val Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly 
            660                 665                 670         


Asn Ser Ala Leu Arg Gly Asn Phe Asn Gln Ala Phe Ala Thr Ala Gly 
        675                 680                 685             


Val Ala Phe Leu Leu Glu Gly Phe Pro Glu Phe Thr Ile Pro Ala Leu 
    690                 695                 700                 


Gly Val Phe Thr Phe Tyr Ser Ser Ile Gln Glu Arg Glu Lys Ile Ile 
705                 710                 715                 720 


Lys Thr Ile Glu Asn Cys Leu Glu Gln Arg Val Lys Arg Trp Lys Asp 
                725                 730                 735     


Ser Tyr Gln Trp Met Val Ser Asn Trp Leu Ser Arg Ile Thr Thr Gln 
            740                 745                 750         


Phe Asn His Ile Asn Tyr Gln Met Tyr Asp Ser Leu Ser Tyr Gln Ala 
        755                 760                 765             


Asp Ala Ile Lys Ala Lys Ile Asp Leu Glu Tyr Lys Lys Tyr Ser Gly 
    770                 775                 780                 


Ser Asp Lys Glu Asn Ile Lys Ser Gln Val Glu Asn Leu Lys Asn Ser 
785                 790                 795                 800 


Leu Asp Val Lys Ile Ser Glu Ala Met Asn Asn Ile Asn Lys Phe Ile 
                805                 810                 815     


Arg Glu Cys Ser Val Thr Tyr Leu Phe Lys Asn Met Leu Pro Lys Val 
            820                 825                 830         


Ile Asp Glu Leu Asn Lys Phe Asp Leu Arg Thr Lys Thr Glu Leu Ile 
        835                 840                 845             


Asn Leu Ile Asp Ser His Asn Ile Ile Leu Val Gly Glu Val Asp Arg 
    850                 855                 860                 


Leu Lys Ala Lys Val Asn Glu Ser Phe Glu Asn Thr Met Pro Phe Asn 
865                 870                 875                 880 


Ile Phe Ser Tyr Thr Asn Asn Ser Leu Leu Lys Asp Ile Ile Asn Glu 
                885                 890                 895     


Tyr Phe Asn Leu Glu Cys Gly Gly Gly Gly Ser Ile Glu Gly Arg His 
            900                 905                 910         


Val Asp Ala Ile Phe Thr Gln Ser Tyr Arg Lys Val Leu Ala Gln Leu 
        915                 920                 925             


Ser Ala Arg Lys Leu Leu Gln Asp Ile Leu Asn Arg Gln Gln Gly Glu 
    930                 935                 940                 


Arg Asn Gln Glu Gln Gly Ala Gly Gly Gly Gly Ser Cys Gly Gly Gly 
945                 950                 955                 960 


Gly Ser His Val Asp Ala Ile Phe Thr Gln Ser Tyr Arg Lys Val Leu 
                965                 970                 975     


Ala Gln Leu Ser Ala Arg Lys Leu Leu Gln Asp Ile Leu Asn Arg Gln 
            980                 985                 990         


Gln Gly Glu Arg Asn Gln Glu Gln  Gly Ala 
        995                 1000         


<210>  13
<211>  2814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  13
atgcatcacc atcaccatca ccatcaccat catgggagct cgaacaataa caacaataac       60

aataacaata acggatccat gacgtggcca gttaaggatt tcaactactc agatcctgta      120

aatgacaacg atattctgta ccttcgcatt ccacaaaata aactgatcac cacaccagtc      180

aaagcattca tgattactca aaacatttgg gtcattccag aacgcttttc tagtgacaca      240

aatccgagtt tatctaaacc tccgcgtccg acgtccaaat atcagagcta ttacgatccc      300

tcatatctca gtacggacga acaaaaagat actttcctta aaggtatcat taaactgttt      360

aagcgtatta atgagcgcga tatcgggaaa aagttgatta attatcttgt tgtgggttcc      420

ccgttcatgg gcgatagctc tacccccgaa gacacttttg attttacccg tcatacgaca      480

aacatcgcgg tagagaagtt tgagaacgga tcgtggaaag tcacaaacat cattacacct      540

agcgtcttaa tttttggtcc gctgccaaac atcttagatt atacagccag cctgactttg      600

caggggcaac agtcgaatcc gagtttcgaa ggttttggta ccctgagcat tctgaaagtt      660

gccccggaat ttctgctcac tttttcagat gtcaccagca accagagctc agcagtatta      720

ggaaagtcaa ttttttgcat ggacccggtt attgcactga tgcacgaact gacgcactct      780

ctgcatcaac tgtatgggat caacatcccc agtgacaaac gtattcgtcc ccaggtgtct      840

gaaggatttt tctcacagga tgggccgaac gtccagttcg aagagttgta tactttcgga      900

ggcctggacg tagagatcat tccccagatt gagcgcagtc agctgcgtga gaaggcattg      960

ggccattata aggatattgc aaaacgcctg aataacatta acaaaacgat tccatcttcg     1020

tggatctcga atattgataa atataagaaa atttttagcg agaaatataa ttttgataaa     1080

gataatacag gtaactttgt ggttaacatt gacaaattca actcccttta cagtgatttg     1140

acgaatgtaa tgagcgaagt tgtgtatagt tcccaataca acgttaagaa tcgtacccat     1200

tacttctctc gtcactacct gccggttttc gcgaacatcc ttgacgataa tatttacact     1260

attcgtgacg gctttaactt gaccaacaag ggcttcaata ttgaaaattc aggccagaac     1320

attgaacgca acccggcctt gcagaaactg tcgagtgaat ccgtggttga cctgtttacc     1380

aaagtctgcg tcgacggcat cattacctcc aaaactaaat ctctgataga aggtagaaac     1440

aaagcgctga acctgcagtg tattaaagtg aaaaacaatc ggctgcctta tgtagcagat     1500

aaagatagca ttagtcagga gattttcgaa aataaaatta tcactgacga aaccaatgtt     1560

cagaattatt cagataaatt ttcactggac gaaagcatct tagatggcca agttccgatt     1620

aacccggaaa ttgttgatcc gttactgccg aacgtgaata tggaaccgtt aaacctccct     1680

ggcgaagaga tcgtatttta tgatgacatt acgaaatatg tggactacct taattcttat     1740

tactatttgg aaagccagaa actgtccaat aacgtggaaa acattactct gaccacaagc     1800

gtggaagagg ctttaggcta ctcaaataag atttatacct tcctcccgtc gctggcggaa     1860

aaagtaaata aaggtgtgca ggctggtctg ttcctcaact gggcgaatga agttgtcgaa     1920

gactttacca cgaatattat gaaaaaggat accctggata aaatctccga cgtctcggtt     1980

attatcccat atattggccc tgcgttaaat atcggtaata gtgcgctgcg ggggaatttt     2040

aaccaggcct ttgctaccgc gggcgtcgcg ttcctcctgg agggctttcc tgaatttact     2100

atcccggcgc tcggtgtttt tacattttac tcttccatcc aggagcgtga gaaaattatc     2160

aaaaccatcg aaaactgcct ggagcagcgg gtgaaacgct ggaaagattc ttatcaatgg     2220

atggtgtcaa actggttatc tcgcatcacg acccaattca accatattaa ttaccagatg     2280

tatgatagtc tgtcgtacca agctgacgcc attaaagcca aaattgatct ggaatataaa     2340

aagtactctg gtagcgataa ggagaacatc aaaagccagg tggagaacct taagaatagt     2400

ctggatgtga aaatctctga agctatgaat aacattaaca aattcattcg tgaatgttcg     2460

gtgacgtacc tgttcaagaa tatgctgcca aaagttattg atgaactgaa taaatttgat     2520

ctgcgtacca aaaccgaact tatcaacctc atcgactccc acaacattat ccttgtgggc     2580

gaagtggatc gtctgaaggc caaagtaaac gagagctttg aaaatacgat gccgtttaat     2640

attttttcat ataccaataa ctccttgctg aaagatatca tcaatgaata tttcaatcta     2700

gaatgtggtg gcggtggctc tggtggcggc ggttctattg aaggtcgcgg tggcggtggc     2760

tctggtggcg gcggttctca gcactggtcc tattgcctgc gccctggttg ataa           2814


<210>  14
<211>  936
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  14

Met His His His His His His His His His His Gly Ser Ser Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Asn Asn Asn Asn Gly Ser Met Thr Trp Pro Val Lys 
            20                  25                  30          


Asp Phe Asn Tyr Ser Asp Pro Val Asn Asp Asn Asp Ile Leu Tyr Leu 
        35                  40                  45              


Arg Ile Pro Gln Asn Lys Leu Ile Thr Thr Pro Val Lys Ala Phe Met 
    50                  55                  60                  


Ile Thr Gln Asn Ile Trp Val Ile Pro Glu Arg Phe Ser Ser Asp Thr 
65                  70                  75                  80  


Asn Pro Ser Leu Ser Lys Pro Pro Arg Pro Thr Ser Lys Tyr Gln Ser 
                85                  90                  95      


Tyr Tyr Asp Pro Ser Tyr Leu Ser Thr Asp Glu Gln Lys Asp Thr Phe 
            100                 105                 110         


Leu Lys Gly Ile Ile Lys Leu Phe Lys Arg Ile Asn Glu Arg Asp Ile 
        115                 120                 125             


Gly Lys Lys Leu Ile Asn Tyr Leu Val Val Gly Ser Pro Phe Met Gly 
    130                 135                 140                 


Asp Ser Ser Thr Pro Glu Asp Thr Phe Asp Phe Thr Arg His Thr Thr 
145                 150                 155                 160 


Asn Ile Ala Val Glu Lys Phe Glu Asn Gly Ser Trp Lys Val Thr Asn 
                165                 170                 175     


Ile Ile Thr Pro Ser Val Leu Ile Phe Gly Pro Leu Pro Asn Ile Leu 
            180                 185                 190         


Asp Tyr Thr Ala Ser Leu Thr Leu Gln Gly Gln Gln Ser Asn Pro Ser 
        195                 200                 205             


Phe Glu Gly Phe Gly Thr Leu Ser Ile Leu Lys Val Ala Pro Glu Phe 
    210                 215                 220                 


Leu Leu Thr Phe Ser Asp Val Thr Ser Asn Gln Ser Ser Ala Val Leu 
225                 230                 235                 240 


Gly Lys Ser Ile Phe Cys Met Asp Pro Val Ile Ala Leu Met His Glu 
                245                 250                 255     


Leu Thr His Ser Leu His Gln Leu Tyr Gly Ile Asn Ile Pro Ser Asp 
            260                 265                 270         


Lys Arg Ile Arg Pro Gln Val Ser Glu Gly Phe Phe Ser Gln Asp Gly 
        275                 280                 285             


Pro Asn Val Gln Phe Glu Glu Leu Tyr Thr Phe Gly Gly Leu Asp Val 
    290                 295                 300                 


Glu Ile Ile Pro Gln Ile Glu Arg Ser Gln Leu Arg Glu Lys Ala Leu 
305                 310                 315                 320 


Gly His Tyr Lys Asp Ile Ala Lys Arg Leu Asn Asn Ile Asn Lys Thr 
                325                 330                 335     


Ile Pro Ser Ser Trp Ile Ser Asn Ile Asp Lys Tyr Lys Lys Ile Phe 
            340                 345                 350         


Ser Glu Lys Tyr Asn Phe Asp Lys Asp Asn Thr Gly Asn Phe Val Val 
        355                 360                 365             


Asn Ile Asp Lys Phe Asn Ser Leu Tyr Ser Asp Leu Thr Asn Val Met 
    370                 375                 380                 


Ser Glu Val Val Tyr Ser Ser Gln Tyr Asn Val Lys Asn Arg Thr His 
385                 390                 395                 400 


Tyr Phe Ser Arg His Tyr Leu Pro Val Phe Ala Asn Ile Leu Asp Asp 
                405                 410                 415     


Asn Ile Tyr Thr Ile Arg Asp Gly Phe Asn Leu Thr Asn Lys Gly Phe 
            420                 425                 430         


Asn Ile Glu Asn Ser Gly Gln Asn Ile Glu Arg Asn Pro Ala Leu Gln 
        435                 440                 445             


Lys Leu Ser Ser Glu Ser Val Val Asp Leu Phe Thr Lys Val Cys Val 
    450                 455                 460                 


Asp Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Ile Glu Gly Arg Asn 
465                 470                 475                 480 


Lys Ala Leu Asn Leu Gln Cys Ile Lys Val Lys Asn Asn Arg Leu Pro 
                485                 490                 495     


Tyr Val Ala Asp Lys Asp Ser Ile Ser Gln Glu Ile Phe Glu Asn Lys 
            500                 505                 510         


Ile Ile Thr Asp Glu Thr Asn Val Gln Asn Tyr Ser Asp Lys Phe Ser 
        515                 520                 525             


Leu Asp Glu Ser Ile Leu Asp Gly Gln Val Pro Ile Asn Pro Glu Ile 
    530                 535                 540                 


Val Asp Pro Leu Leu Pro Asn Val Asn Met Glu Pro Leu Asn Leu Pro 
545                 550                 555                 560 


Gly Glu Glu Ile Val Phe Tyr Asp Asp Ile Thr Lys Tyr Val Asp Tyr 
                565                 570                 575     


Leu Asn Ser Tyr Tyr Tyr Leu Glu Ser Gln Lys Leu Ser Asn Asn Val 
            580                 585                 590         


Glu Asn Ile Thr Leu Thr Thr Ser Val Glu Glu Ala Leu Gly Tyr Ser 
        595                 600                 605             


Asn Lys Ile Tyr Thr Phe Leu Pro Ser Leu Ala Glu Lys Val Asn Lys 
    610                 615                 620                 


Gly Val Gln Ala Gly Leu Phe Leu Asn Trp Ala Asn Glu Val Val Glu 
625                 630                 635                 640 


Asp Phe Thr Thr Asn Ile Met Lys Lys Asp Thr Leu Asp Lys Ile Ser 
                645                 650                 655     


Asp Val Ser Val Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly 
            660                 665                 670         


Asn Ser Ala Leu Arg Gly Asn Phe Asn Gln Ala Phe Ala Thr Ala Gly 
        675                 680                 685             


Val Ala Phe Leu Leu Glu Gly Phe Pro Glu Phe Thr Ile Pro Ala Leu 
    690                 695                 700                 


Gly Val Phe Thr Phe Tyr Ser Ser Ile Gln Glu Arg Glu Lys Ile Ile 
705                 710                 715                 720 


Lys Thr Ile Glu Asn Cys Leu Glu Gln Arg Val Lys Arg Trp Lys Asp 
                725                 730                 735     


Ser Tyr Gln Trp Met Val Ser Asn Trp Leu Ser Arg Ile Thr Thr Gln 
            740                 745                 750         


Phe Asn His Ile Asn Tyr Gln Met Tyr Asp Ser Leu Ser Tyr Gln Ala 
        755                 760                 765             


Asp Ala Ile Lys Ala Lys Ile Asp Leu Glu Tyr Lys Lys Tyr Ser Gly 
    770                 775                 780                 


Ser Asp Lys Glu Asn Ile Lys Ser Gln Val Glu Asn Leu Lys Asn Ser 
785                 790                 795                 800 


Leu Asp Val Lys Ile Ser Glu Ala Met Asn Asn Ile Asn Lys Phe Ile 
                805                 810                 815     


Arg Glu Cys Ser Val Thr Tyr Leu Phe Lys Asn Met Leu Pro Lys Val 
            820                 825                 830         


Ile Asp Glu Leu Asn Lys Phe Asp Leu Arg Thr Lys Thr Glu Leu Ile 
        835                 840                 845             


Asn Leu Ile Asp Ser His Asn Ile Ile Leu Val Gly Glu Val Asp Arg 
    850                 855                 860                 


Leu Lys Ala Lys Val Asn Glu Ser Phe Glu Asn Thr Met Pro Phe Asn 
865                 870                 875                 880 


Ile Phe Ser Tyr Thr Asn Asn Ser Leu Leu Lys Asp Ile Ile Asn Glu 
                885                 890                 895     


Tyr Phe Asn Leu Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            900                 905                 910         


Ile Glu Gly Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln His 
        915                 920                 925             


Trp Ser Tyr Cys Leu Arg Pro Gly 
    930                 935     


<210>  15
<211>  2793
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  15
atgcatcacc atcaccatca ccatcaccat catgggagct cgaacaataa caacaataac       60

aataacaata acggatccat ggagttcgtt aacaaacagt tcaactataa agacccagtt      120

aacggtgttg acattgctta catcaaaatc ccgaacgctg gccagatgca gccggtaaag      180

gcattcaaaa tccacaacaa aatctgggtt atcccggaac gtgatacctt tactaacccg      240

gaagaaggtg acctgaaccc gccaccggaa gcgaaacagg tgccggtatc ttactatgac      300

tccacctacc tgtctaccga taacgaaaag gacaactacc tgaaaggtgt tactaaactg      360

ttcgagcgta tttactccac cgacctgggc cgtatgctgc tgactagcat cgttcgcggt      420

atcccgttct ggggcggttc taccatcgat accgaactga aagtaatcga cactaactgc      480

atcaacgtta ttcagccgga cggttcctat cgttccgaag aactgaacct ggtgatcatc      540

ggcccgtctg ctgatatcat ccagttcgag tgtaagagct ttggtcacga agttctgaac      600

ctcacccgta acggctacgg ttccactcag tacatccgtt tctctccgga cttcaccttc      660

ggttttgaag aatccctgga agtagacacg aacccactgc tgggcgctgg taaattcgca      720

actgatcctg cggttaccct ggctcacgaa ctgattcatg caggccaccg cctgtacggt      780

atcgccatca atccgaaccg tgtcttcaaa gttaacacca acgcgtatta cgagatgtcc      840

ggtctggaag ttagcttcga agaactgcgt acttttggcg gtcacgacgc taaattcatc      900

gactctctgc aagaaaacga gttccgtctg tactactata acaagttcaa agatatcgca      960

tccaccctga acaaagcgaa atccatcgtg ggtaccactg cttctctcca gtacatgaag     1020

aacgttttta aagaaaaata cctgctcagc gaagacacct ccggcaaatt ctctgtagac     1080

aagttgaaat tcgataaact ttacaaaatg ctgactgaaa tttacaccga agacaacttc     1140

gttaagttct ttaaagttct gaaccgcaaa acctatctga acttcgacaa ggcagtattc     1200

aaaatcaaca tcgtgccgaa agttaactac actatctacg atggtttcaa cctgcgtaac     1260

accaacctgg ctgctaattt taacggccag aacacggaaa tcaacaacat gaacttcaca     1320

aaactgaaaa acttcactgg tctgttcgag ttttacaagc tgctgtgcgt cgacggcatc     1380

attacctcca aaactaaatc tctgatagaa ggtagaaaca aagcgctgaa cgacctctgt     1440

atcaaggtta acaactggga tttattcttc agcccgagtg aagacaactt caccaacgac     1500

ctgaacaaag gtgaagaaat cacctcagat actaacatcg aagcagccga agaaaacatc     1560

tcgctggacc tgatccagca gtactacctg acctttaatt tcgacaacga gccggaaaac     1620

atttctatcg aaaacctgag ctctgatatc atcggccagc tggaactgat gccgaacatc     1680

gaacgtttcc caaacggtaa aaagtacgag ctggacaaat ataccatgtt ccactacctg     1740

cgcgcgcagg aatttgaaca cggcaaatcc cgtatcgcac tgactaactc cgttaacgaa     1800

gctctgctca acccgtcccg tgtatacacc ttcttctcta gcgactacgt gaaaaaggtc     1860

aacaaagcga ctgaagctgc aatgttcttg ggttgggttg aacagcttgt ttatgatttt     1920

accgacgaga cgtccgaagt atctactacc gacaaaattg cggatatcac tatcatcatc     1980

ccgtacatcg gtccggctct gaacattggc aacatgctgt acaaagacga cttcgttggc     2040

gcactgatct tctccggtgc ggtgatcctg ctggagttca tcccggaaat cgccatcccg     2100

gtactgggca cctttgctct ggtttcttac attgcaaaca aggttctgac tgtacaaacc     2160

atcgacaacg cgctgagcaa acgtaacgaa aaatgggatg aagtttacaa atatatcgtg     2220

accaactggc tggctaaggt taatactcag atcgacctca tccgcaaaaa aatgaaagaa     2280

gcactggaaa accaggcgga agctaccaag gcaatcatta actaccagta caaccagtac     2340

accgaggaag aaaaaaacaa catcaacttc aacatcgacg atctgtcctc taaactgaac     2400

gaatccatca acaaagctat gatcaacatc aacaagttcc tgaaccagtg ctctgtaagc     2460

tatctgatga actccatgat cccgtacggt gttaaacgtc tggaggactt cgatgcgtct     2520

ctgaaagacg ccctgctgaa atacatttac gacaaccgtg gcactctgat cggtcaggtt     2580

gatcgtctga aggacaaagt gaacaatacc ttatcgaccg acatcccttt tcagctcagt     2640

aaatatgtcg ataaccaacg ccttttgtcc acttgtggcg gtggcggtag catcgaaggt     2700

cgtgttccat taccagcagg aggaggaaca gtattgacta aaatgtatcc atgcggaaat     2760

cactgggcag tgggacatct aatgggatga taa                                  2793


<210>  16
<211>  929
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  16

Met His His His His His His His His His His Gly Ser Ser Asn Asn 
1               5                   10                  15      


Asn Asn Asn Asn Asn Asn Asn Asn Gly Ser Met Glu Phe Val Asn Lys 
            20                  25                  30          


Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp Ile Ala Tyr Ile 
        35                  40                  45              


Lys Ile Pro Asn Ala Gly Gln Met Gln Pro Val Lys Ala Phe Lys Ile 
    50                  55                  60                  


His Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr Phe Thr Asn Pro 
65                  70                  75                  80  


Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys Gln Val Pro Val 
                85                  90                  95      


Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn Glu Lys Asp Asn 
            100                 105                 110         


Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile Tyr Ser Thr Asp 
        115                 120                 125             


Leu Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile Pro Phe Trp 
    130                 135                 140                 


Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp Thr Asn Cys 
145                 150                 155                 160 


Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu Glu Leu Asn 
                165                 170                 175     


Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln Phe Glu Cys Lys 
            180                 185                 190         


Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn Gly Tyr Gly Ser 
        195                 200                 205             


Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu 
    210                 215                 220                 


Ser Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala Gly Lys Phe Ala 
225                 230                 235                 240 


Thr Asp Pro Ala Val Thr Leu Ala His Glu Leu Ile His Ala Gly His 
                245                 250                 255     


Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe Lys Val Asn 
            260                 265                 270         


Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val Ser Phe Glu Glu 
        275                 280                 285             


Leu Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp Ser Leu Gln 
    290                 295                 300                 


Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile Ala 
305                 310                 315                 320 


Ser Thr Leu Asn Lys Ala Lys Ser Ile Val Gly Thr Thr Ala Ser Leu 
                325                 330                 335     


Gln Tyr Met Lys Asn Val Phe Lys Glu Lys Tyr Leu Leu Ser Glu Asp 
            340                 345                 350         


Thr Ser Gly Lys Phe Ser Val Asp Lys Leu Lys Phe Asp Lys Leu Tyr 
        355                 360                 365             


Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val Lys Phe Phe 
    370                 375                 380                 


Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn Phe Asp Lys Ala Val Phe 
385                 390                 395                 400 


Lys Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr Asp Gly Phe 
                405                 410                 415     


Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr 
            420                 425                 430         


Glu Ile Asn Asn Met Asn Phe Thr Lys Leu Lys Asn Phe Thr Gly Leu 
        435                 440                 445             


Phe Glu Phe Tyr Lys Leu Leu Cys Val Asp Gly Ile Ile Thr Ser Lys 
    450                 455                 460                 


Thr Lys Ser Leu Ile Glu Gly Arg Asn Lys Ala Leu Asn Asp Leu Cys 
465                 470                 475                 480 


Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn 
                485                 490                 495     


Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr Asn 
            500                 505                 510         


Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln Tyr 
        515                 520                 525             


Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile Glu 
    530                 535                 540                 


Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn Ile 
545                 550                 555                 560 


Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr Met 
                565                 570                 575     


Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser Arg Ile 
            580                 585                 590         


Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser Arg Val 
        595                 600                 605             


Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn Lys Ala Thr 
    610                 615                 620                 


Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr Asp Phe 
625                 630                 635                 640 


Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala Asp Ile 
                645                 650                 655     


Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn Met 
            660                 665                 670         


Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala Val 
        675                 680                 685             


Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr 
    690                 695                 700                 


Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu Thr Val Gln Thr 
705                 710                 715                 720 


Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu Val Tyr 
                725                 730                 735     


Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr Gln Ile Asp 
            740                 745                 750         


Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala Glu Ala 
        755                 760                 765             


Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu 
    770                 775                 780                 


Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu Asn 
785                 790                 795                 800 


Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln 
                805                 810                 815     


Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly Val Lys 
            820                 825                 830         


Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys Tyr 
        835                 840                 845             


Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp Arg Leu Lys 
    850                 855                 860                 


Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser 
865                 870                 875                 880 


Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Cys Gly Gly Gly Gly 
                885                 890                 895     


Ser Ile Glu Gly Arg Val Pro Leu Pro Ala Gly Gly Gly Thr Val Leu 
            900                 905                 910         


Thr Lys Met Tyr Pro Cys Gly Asn His Trp Ala Val Gly His Leu Met 
        915                 920                 925             


Gly 
    


