                         SEQUENCE LISTING

<110>  Fundaci Clnic per la Recerca Biomdica
       Hospital Clnic i Provincial de Barcelona
       Universitat de Barcelona
 
<120>  Compounds derived from scavenger-like lymphocyte receptors 
       for use in immunotherapy

<130>  155 665 n17

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  1573
<212>  DNA
<213>  Homo sapiens

<400>  1
gagatacccg gccagacacc ctcacctgcg gtgcccagct gcccaggctg aggcaagaga       60

aggccagaaa ccatgcccat ggggtctctg caaccgctgg ccaccttgta cctgctgggg      120

atgctggtcg cttcctgcct cggacggctc agctggtatg acccagattt ccaggcaagg      180

ctcacccgtt ccaactcgaa gtgccagggc cagctggagg tctacctcaa ggacggatgg      240

cacatggttt gcagccagag ctggggccgg agctccaagc agtgggagga ccccagtcaa      300

gcgtcaaaag tctgccagcg gctgaactgt ggggtgccct taagccttgg ccccttcctt      360

gtcacctaca cacctcagag ctcaatcatc tgctacggac aactgggctc cttctccaac      420

tgcagccaca gcagaaatga catgtgtcac tctctgggcc tgacctgctt agaaccccag      480

aagacaacac ctccaacgac aaggcccccg cccaccacaa ctccagagcc cacagctcct      540

cccaggctgc agctggtggc acagtctggc ggccagcact gtgccggcgt ggtggagttc      600

tacagcggca gcctgggggg taccatcagc tatgaggccc aggacaagac ccaggacctg      660

gagaacttcc tctgcaacaa cctccagtgt ggctccttct tgaagcatct gccagagact      720

gaggcaggca gagcccaaga cccaggggag ccacgggaac accagccctt gccaatccaa      780

tggaagatcc agaactcaag ctgtacctcc ctggagcatt gcttcaggaa aatcaagccc      840

cagaaaagtg gccgagttct tgccctcctt tgctcaggtt tccagcccaa ggtgcagagc      900

cgtctggtgg ggggcagcag catctgtgaa ggcaccgtgg aggtgcgcca gggggctcag      960

tgggcagccc tgtgtgacag ctcttcagcc aggagctcgc tgcggtggga ggaggtgtgc     1020

cgggagcagc agtgtggcag cgtcaactcc tatcgagtgc tggacgctgg tgacccaaca     1080

tcccgggggc tcttctgtcc ccatcagaag ctgtcccagt gccacgaact ttgggagaga     1140

aattcctact gcaagaaggt gtttgtcaca tgccaggatt aaaaccccgc aggcctggcc     1200

gcaggcacgg tggcaagcat catcctggcc ctggtgctcc tggtggtgct gctggtcgtg     1260

tgcggccccc ttgcctacaa gaagctagtg aagaaattcc gccagaagaa gcagcgccag     1320

tggattggcc caacgggaat gaaccaaaac atgtctttcc atcgcaacca cacggcaacc     1380

gtccgatccc atgctgagaa ccccacagcc tcccacgtgg ataacgaata cagccaacct     1440

cccaggaact cccgcctgtc agcttatcca gctctggaag gggttctgca tcgctcctcc     1500

atgcagcctg acaactcctc cgacagtgac tatgatctgc atggggctca gaggctgtaa     1560

agaactggga tcc                                                        1573


<210>  2
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Leu Ser Trp Tyr Asp Pro Asp Phe Gln Ala Arg Leu Thr Arg Ser 
1               5                   10                  15      


Asn Ser Lys Cys Gln Gly Gln Leu Glu Val Tyr Leu Lys Asp Gly Trp 
            20                  25                  30          


His Met Val Cys Ser Gln Ser Trp Gly Arg Ser Ser Lys Gln Trp Glu 
        35                  40                  45              


Asp Pro Ser Gln Ala Ser Lys Val Cys Gln Arg Leu Asn Cys Gly Val 
    50                  55                  60                  


Pro Leu Ser Leu Gly Pro Phe Leu Val Thr Tyr Thr Pro Gln Ser Ser 
65                  70                  75                  80  


Ile Ile Cys Tyr Gly Gln Leu Gly Ser Phe Ser Asn Cys Ser His Ser 
                85                  90                  95      


Arg Asn Asp Met Cys His Ser Leu Gly Leu Thr Cys Leu Glu Pro Gln 
            100                 105                 110         


Lys Thr Thr Pro Pro Thr Thr Arg Pro Pro Pro Thr Thr Thr Pro Glu 
        115                 120                 125             


Pro Thr Ala Pro Pro Arg Leu Gln Leu Val Ala Gln Ser Gly Gly Gln 
    130                 135                 140                 


His Cys Ala Gly Val Val Glu Phe Tyr Ser Gly Ser Leu Gly Gly Thr 
145                 150                 155                 160 


Ile Ser Tyr Glu Ala Gln Asp Lys Thr Gln Asp Leu Glu Asn Phe Leu 
                165                 170                 175     


Cys Asn Asn Leu Gln Cys Gly Ser Phe Leu Lys His Leu Pro Glu Thr 
            180                 185                 190         


Glu Ala Gly Arg Ala Gln Asp Pro Gly Glu Pro Arg Glu His Gln Pro 
        195                 200                 205             


Leu Pro Ile Gln Trp Lys Ile Gln Asn Ser Ser Cys Thr Ser Leu Glu 
    210                 215                 220                 


His Cys Phe Arg Lys Ile Lys Pro Gln Lys Ser Gly Arg Val Leu Ala 
225                 230                 235                 240 


Leu Leu Cys Ser Gly Phe Gln Pro Lys Val Gln Ser Arg Leu Val Gly 
                245                 250                 255     


Gly Ser Ser Ile Cys Glu Gly Thr Val Glu Val Arg Gln Gly Ala Gln 
            260                 265                 270         


Trp Ala Ala Leu Cys Asp Ser Ser Ser Ala Arg Ser Ser Leu Arg Trp 
        275                 280                 285             


Glu Glu Val Cys Arg Glu Gln Gln Cys Gly Ser Val Asn Ser Tyr Arg 
    290                 295                 300                 


Val Leu Asp Ala Gly Asp Pro Thr Ser Arg Gly Leu Phe Cys Pro His 
305                 310                 315                 320 


Gln Lys Leu Ser Gln Cys His Glu Leu Trp Glu Arg Asn Ser Tyr Cys 
                325                 330                 335     


Lys Lys Val Phe Val Thr Cys Gln Asp 
            340                 345 


<210>  3
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Gln Leu Asn Thr Ser Ser Ala Glu Ser Glu Leu Trp Glu Pro Gly 
1               5                   10                  15      


Glu Arg Leu Pro Val Arg Leu Thr Asn Gly Ser Ser Ser Cys Ser Gly 
            20                  25                  30          


Thr Val Glu Val Arg Leu Glu Ala Ser Trp Glu Pro Ala Cys Gly Ala 
        35                  40                  45              


Leu Trp Asp Ser Arg Ala Ala Glu Ala Val Cys Arg Ala Leu Gly Cys 
    50                  55                  60                  


Gly Gly Ala Glu Ala Ala Ser Gln Leu Ala Pro Pro Thr Pro Glu Leu 
65                  70                  75                  80  


Pro Pro Pro Pro Ala Ala Gly Asn Thr Ser Val Ala Ala Asn Ala Thr 
                85                  90                  95      


Leu Ala Gly Ala Pro Ala Leu Leu Cys Ser Gly Ala Glu Trp Arg Leu 
            100                 105                 110         


Cys Glu Val Val Glu His Ala Cys Arg Ser Asp Gly Arg Arg Ala Arg 
        115                 120                 125             


Val Thr Cys Ala Glu Asn Arg Ala Leu Arg Leu Val Asp Gly Gly Gly 
    130                 135                 140                 


Ala Cys Ala Gly Arg Val Glu Met Leu Glu His Gly Glu Trp Gly Ser 
145                 150                 155                 160 


Val Cys Asp Asp Thr Trp Asp Leu Glu Asp Ala His Val Val Cys Arg 
                165                 170                 175     


Gln Leu Gly Cys Gly Trp Ala Val Gln Ala Leu Pro Gly Leu His Phe 
            180                 185                 190         


Thr Pro Gly Arg Gly Pro Ile His Arg Asp Gln Val Asn Cys Ser Gly 
        195                 200                 205             


Ala Glu Ala Tyr Leu Trp Asp Cys Pro Gly Leu Pro Gly Gln His Tyr 
    210                 215                 220                 


Cys Gly His Lys Glu Asp Ala Gly Val Val Cys Ser Glu His Gln Ser 
225                 230                 235                 240 


Trp Arg Leu Thr Gly Gly Ala Asp Arg Cys Glu Gly Gln Val Glu Val 
                245                 250                 255     


His Phe Arg Gly Val Trp Asn Thr Val Cys Asp Ser Glu Trp Tyr Pro 
            260                 265                 270         


Ser Glu Ala Lys Val Leu Cys Gln Ser Leu Gly Cys Gly Thr Ala Val 
        275                 280                 285             


Glu Arg Pro Lys Gly Leu Pro His Ser Leu Ser Gly Arg Met Tyr Tyr 
    290                 295                 300                 


Ser Cys Asn Gly Glu Glu Leu Thr Leu Ser Asn Cys Ser Trp Arg Phe 
305                 310                 315                 320 


Asn Asn Ser Asn Leu Cys Ser Gln Ser Leu Ala Ala Arg Val Leu Cys 
                325                 330                 335     


Ser Ala Ser Arg Ser Leu His Asn Leu Ser Thr Pro Glu Val Pro Ala 
            340                 345                 350         


Ser Val Gln Thr Val Thr Ile Glu Ser Ser Val Thr Val Lys Ile Glu 
        355                 360                 365             


Asn Lys Glu Ser Arg 
    370             


<210>  4
<211>  1182
<212>  DNA
<213>  Homo sapiens

<400>  4
gagatacccg gccagacacc ctcacctgcg gtgcccagct gcccaggctg aggcaagaga       60

aggccagaaa ccatgcccat ggggtctctg caaccgctgg ccaccttgta cctgctgggg      120

atgctggtcg cttcctgcct cggacggctc agctggtatg acccagattt ccaggcaagg      180

ctcacccgtt ccaactcgaa gtgccagggc cagctggagg tctacctcaa ggacggatgg      240

cacatggttt gcagccagag ctggggccgg agctccaagc agtgggagga ccccagtcaa      300

gcgtcaaaag tctgccagcg gctgaactgt ggggtgccct taagccttgg ccccttcctt      360

gtcacctaca cacctcagag ctcaatcatc tgctacggac aactgggctc cttctccaac      420

tgcagccaca gcagaaatga catgtgtcac tctctgggcc tgacctgctt agaaccccag      480

aagacaacac ctccaacgac aaggcccccg cccaccacaa ctccagagcc cacagctcct      540

cccaggctgc agctggtggc acagtctggc ggccagcact gtgccggcgt ggtggagttc      600

tacagcggca gcctgggggg taccatcagc tatgaggccc aggacaagac ccaggacctg      660

gagaacttcc tctgcaacaa cctccagtgt ggctccttct tgaagcatct gccagagact      720

gaggcaggca gagcccaaga cccaggggag ccacgggaac accagccctt gccaatccaa      780

tggaagatcc agaactcaag ctgtacctcc ctggagcatt gcttcaggaa aatcaagccc      840

cagaaaagtg gccgagttct tgccctcctt tgctcaggtt tccagcccaa ggtgcagagc      900

cgtctggtgg ggggcagcag catctgtgaa ggcaccgtgg aggtgcgcca gggggctcag      960

tgggcagccc tgtgtgacag ctcttcagcc aggagctcgc tgcggtggga ggaggtgtgc     1020

cgggagcagc agtgtggcag cgtcaactcc tatcgagtgc tggacgctgg tgacccaaca     1080

tcccgggggc tcttctgtcc ccatcagaag ctgtcccagt gccacgaact ttgggagaga     1140

aattcctact gcaagaaggt gtttgtcaca tgccaggatt aa                        1182


<210>  5
<211>  1128
<212>  DNA
<213>  Homo sapiens

<400>  5
gaccagctca acaccagcag tgcagagagt gagctctggg agccagggga gcggcttccg       60

gtccgtctga caaacgggag cagcagctgc agcgggacgg tggaggtgcg gctcgaggcg      120

tcctgggagc ccgcgtgcgg ggcgctctgg gacagccgcg ccgccgaggc cgtgtgccga      180

gcactgggct gcggcggggc ggaggccgcc tctcagctcg ccccgccgac ccctgagctg      240

ccgcccccgc ctgcagccgg gaacaccagc gtagcagcta atgccactct ggccggggcg      300

cccgccctcc tgtgcagcgg cgccgagtgg cggctctgcg aggtggtgga gcacgcgtgc      360

cgcagcgacg ggaggcgggc ccgtgtcacc tgtgcagaga accgcgcgct gcgcctggtg      420

gacggtggcg gcgcctgcgc cggccgcgtg gagatgctgg agcatggcga gtggggatca      480

gtgtgcgatg acacttggga cctggaggac gcccacgtgg tgtgcaggca actgggctgc      540

ggctgggcag tccaggccct gcccggcttg cacttcacgc ccggccgcgg gcctatccac      600

cgggaccagg tgaactgctc gggggccgaa gcttacctgt gggactgccc ggggctgcca      660

ggacagcact actgcggcca caaagaggac gcgggcgtgg tgtgctcaga gcaccagtcc      720

tggcgcctga cagggggcgc tgaccgctgc gaggggcagg tggaggtaca cttccgaggg      780

gtctggaaca cagtgtgtga cagtgagtgg tacccatcgg aggccaaggt gctctgccag      840

tccttgggct gtggaactgc ggttgagagg cccaaggggc tgccccactc cttgtccggc      900

aggatgtact actcatgcaa tggggaggag ctcaccctct ccaactgctc ctggcggttc      960

aacaactcca acctctgcag ccagtcgctg gcagccaggg tcctctgctc agcttcccgg     1020

agtttgcaca atctgtccac tcccgaagtc cctgcaagtg ttcagacagt cactatagaa     1080

tcttctgtga cagtgaaaat agagaacaag gaatctcggt agggatcc                  1128


<210>  6
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for PCR amplification of human CD5.

<400>  6
gctgtcccag tgccacgaac t                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer PCR amplification of human CD5

<400>  7
gaagctcctc tgtgtcctca t                                                 21


<210>  8
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer PCR amplification of house-keeping LIEX gene

<400>  8
tcactcaagg caaccttcct gc                                                22


<210>  9
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer PCR amplification of house-keeping LIEX gene

<400>  9
cgacctcatc tctaaccatg aacag                                             25


<210>  10
<211>  268
<212>  DNA
<213>  Simian virus 40

<400>  10
gtgtggaaag tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta       60

gtcagcaacc aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat      120

gcatctcaat tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac      180

tccgcccagt tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga      240

ggccgaggcc gcctcggcct ctgagcta                                         268


<210>  11
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer PCR amplification of human CD6 ectodomain 
       (extracellular portion)

<400>  11
cttctagatg accagctcaa caccaccagc a                                      31


<210>  12
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for PCR amplification of human CD6 ectodomain 
       (extracellular portion)

<400>  12
gcggatccct attctatagt gactgtctga aca                                    33


<210>  13
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly Arg Leu Ser Trp Tyr Asp Pro Asp 
            20                  25                  30          


Phe Gln Ala Arg Leu Thr Arg Ser Asn Ser Lys Cys Gln Gly Gln Leu 
        35                  40                  45              


Glu Val Tyr Leu Lys Asp Gly Trp His Met Val Cys Ser Gln Ser Trp 
    50                  55                  60                  


Gly Arg Ser Ser Lys Gln Trp Glu Asp Pro Ser Gln Ala Ser Lys Val 
65                  70                  75                  80  


Cys Gln Arg Leu Asn Cys Gly Val Pro Leu Ser Leu Gly Pro Phe Leu 
                85                  90                  95      


Val Thr Tyr Thr Pro Gln Ser Ser Ile Ile Cys Tyr Gly Gln Leu Gly 
            100                 105                 110         


Ser Phe Ser Asn Cys Ser His Ser Arg Asn Asp Met Cys His Ser Leu 
        115                 120                 125             


Gly Leu Thr Cys Leu Glu Pro Gln Lys Thr Thr Pro Pro Thr Thr Arg 
    130                 135                 140                 


Pro Pro Pro Thr Thr Thr Pro Glu Pro Thr Ala Pro Pro Arg Leu Gln 
145                 150                 155                 160 


Leu Val Ala Gln Ser Gly Gly Gln His Cys Ala Gly Val Val Glu Phe 
                165                 170                 175     


Tyr Ser Gly Ser Leu Gly Gly Thr Ile Ser Tyr Glu Ala Gln Asp Lys 
            180                 185                 190         


Thr Gln Asp Leu Glu Asn Phe Leu Cys Asn Asn Leu Gln Cys Gly Ser 
        195                 200                 205             


Phe Leu Lys His Leu Pro Glu Thr Glu Ala Gly Arg Ala Gln Asp Pro 
    210                 215                 220                 


Gly Glu Pro Arg Glu His Gln Pro Leu Pro Ile Gln Trp Lys Ile Gln 
225                 230                 235                 240 


Asn Ser Ser Cys Thr Ser Leu Glu His Cys Phe Arg Lys Ile Lys Pro 
                245                 250                 255     


Gln Lys Ser Gly Arg Val Leu Ala Leu Leu Cys Ser Gly Phe Gln Pro 
            260                 265                 270         


Lys Val Gln Ser Arg Leu Val Gly Gly Ser Ser Ile Cys Glu Gly Thr 
        275                 280                 285             


Val Glu Val Arg Gln Gly Ala Gln Trp Ala Ala Leu Cys Asp Ser Ser 
    290                 295                 300                 


Ser Ala Arg Ser Ser Leu Arg Trp Glu Glu Val Cys Arg Glu Gln Gln 
305                 310                 315                 320 


Cys Gly Ser Val Asn Ser Tyr Arg Val Leu Asp Ala Gly Asp Pro Thr 
                325                 330                 335     


Ser Arg Gly Leu Phe Cys Pro His Gln Lys Leu Ser Gln Cys His Glu 
            340                 345                 350         


Leu Trp Glu Arg Asn Ser Tyr Cys Lys Lys Val Phe Val Thr Cys Gln 
        355                 360                 365             


Asp 
    


<210>  14
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly 
            20                  


