                         SEQUENCE LISTING

<110>  Helmholtz Zentrum Mnchen
 
<120>  Improved Recombination Efficiency by Inhibition of NHEJ DNA 
       Repair

<130>  T1473 PCT

<150>  EP 11 00 4637.2
<151>  2011-06-07

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  260
<212>  PRT
<213>  Mus musculus

<400>  1

Val Asn Lys Val Ser Asn Val Phe Glu Asp Val Glu Phe Cys Val Met 
1               5                   10                  15      


Ser Gly Leu Asp Gly Tyr Pro Lys Ala Asp Leu Glu Asn Arg Ile Ala 
            20                  25                  30          


Glu Phe Gly Gly Tyr Ile Val Gln Asn Pro Gly Pro Asp Thr Tyr Cys 
        35                  40                  45              


Val Ile Ala Gly Ser Glu Asn Val Arg Val Lys Asn Ile Ile Ser Ser 
    50                  55                  60                  


Asp Lys Asn Asp Val Val Lys Pro Glu Trp Leu Leu Glu Cys Phe Lys 
65                  70                  75                  80  


Thr Lys Thr Cys Val Pro Trp Gln Pro Arg Phe Met Ile His Met Cys 
                85                  90                  95      


Pro Ser Thr Lys Gln His Phe Ala Arg Glu Tyr Asp Cys Tyr Gly Asp 
            100                 105                 110         


Ser Tyr Phe Val Asp Thr Asp Leu Asp Gln Leu Lys Glu Val Phe Leu 
        115                 120                 125             


Gly Ile Lys Pro Ser Glu Gln Gln Thr Pro Glu Glu Met Ala Pro Val 
    130                 135                 140                 


Ile Ala Asp Leu Glu Cys Arg Tyr Ser Trp Asp His Ser Pro Leu Ser 
145                 150                 155                 160 


Met Phe Arg His Tyr Thr Ile Tyr Leu Asp Leu Tyr Ala Val Ile Asn 
                165                 170                 175     


Asp Leu Ser Ser Arg Ile Glu Ala Thr Arg Leu Gly Ile Thr Ala Leu 
            180                 185                 190         


Glu Leu Arg Phe His Gly Ala Lys Val Val Ser Cys Leu Ser Glu Gly 
        195                 200                 205             


Val Ser His Val Ile Ile Gly Glu Asp Gln Arg Arg Val Thr Asp Phe 
    210                 215                 220                 


Lys Ile Phe Arg Arg Met Leu Lys Lys Lys Phe Lys Ile Leu Gln Glu 
225                 230                 235                 240 


Ser Trp Val Ser Asp Ser Val Asp Lys Gly Glu Leu Gln Glu Glu Asn 
                245                 250                 255     


Gln Tyr Leu Leu 
            260 


<210>  2
<211>  56
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Cys Tyr Gly Asp Ser Tyr Phe Val Asp Thr Asp Leu Asp Gln Leu 
1               5                   10                  15      


Lys Glu Val Phe Leu Gly Ile Lys Pro Ser Glu Gln Gln Thr Pro Glu 
            20                  25                  30          


Glu Met Ala Pro Val Ile Ala Asp Leu Glu Cys Arg Tyr Ser Trp Asp 
        35                  40                  45              


His Ser Pro Leu Ser Met Phe Arg 
    50                  55      


<210>  3
<211>  547
<212>  PRT
<213>  Mus musculus

<400>  3

Ile Gln Cys Ile Gln Ser Val Tyr Thr Ser Lys Ile Ile Ser Ser Asp 
1               5                   10                  15      


Arg Asp Leu Leu Ala Val Val Phe Tyr Gly Thr Glu Lys Asp Lys Asn 
            20                  25                  30          


Ser Val Asn Phe Lys Asn Ile Tyr Val Leu Gln Asp Leu Asp Asn Pro 
        35                  40                  45              


Gly Ala Lys Arg Val Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly 
    50                  55                  60                  


Lys Lys His Phe Arg Asp Thr Val Gly His Gly Ser Asp Tyr Ser Leu 
65                  70                  75                  80  


Ser Glu Val Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Leu 
                85                  90                  95      


Lys Met Ser His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asp Pro 
            100                 105                 110         


His Gly Arg Asp Ser Ala Lys Ala Ser Arg Ala Arg Thr Lys Ala Ser 
        115                 120                 125             


Asp Leu Arg Asp Thr Gly Ile Phe Leu Asp Leu Met His Leu Lys Lys 
    130                 135                 140                 


Pro Gly Gly Phe Asp Val Ser Val Phe Tyr Arg Asp Ile Ile Thr Thr 
145                 150                 155                 160 


Ala Glu Asp Glu Asp Leu Gly Val His Phe Glu Glu Ser Ser Lys Leu 
                165                 170                 175     


Glu Asp Leu Leu Arg Lys Val Arg Ala Lys Glu Thr Lys Lys Arg Val 
            180                 185                 190         


Leu Ser Arg Leu Lys Phe Lys Leu Gly Glu Asp Val Val Leu Met Val 
        195                 200                 205             


Gly Ile Tyr Asn Leu Val Gln Lys Ala Asn Lys Pro Phe Pro Val Arg 
    210                 215                 220                 


Leu Tyr Arg Glu Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe 
225                 230                 235                 240 


Asn Val Asn Thr Gly Ser Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser 
                245                 250                 255     


Leu Thr Tyr Gly Thr Arg Gln Ile Val Leu Glu Lys Glu Glu Thr Glu 
            260                 265                 270         


Glu Leu Lys Arg Phe Asp Glu Pro Gly Leu Ile Leu Met Gly Phe Lys 
        275                 280                 285             


Pro Thr Val Met Leu Lys Lys Gln His Tyr Leu Arg Pro Ser Leu Phe 
    290                 295                 300                 


Val Tyr Pro Glu Glu Ser Leu Val Ser Gly Ser Ser Thr Leu Phe Ser 
305                 310                 315                 320 


Ala Leu Leu Thr Lys Cys Val Glu Lys Lys Val Ile Ala Val Cys Arg 
                325                 330                 335     


Tyr Thr Pro Arg Lys Asn Val Ser Pro Tyr Phe Val Ala Leu Val Pro 
            340                 345                 350         


Gln Glu Glu Glu Leu Asp Asp Gln Asn Ile Gln Val Thr Pro Gly Gly 
        355                 360                 365             


Phe Gln Leu Val Phe Leu Pro Tyr Ala Asp Asp Lys Arg Lys Val Pro 
    370                 375                 380                 


Phe Thr Glu Lys Val Thr Ala Asn Gln Glu Gln Ile Asp Lys Met Lys 
385                 390                 395                 400 


Ala Ile Val Gln Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu 
                405                 410                 415     


Asn Pro Val Leu Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu 
            420                 425                 430         


Asp Met Met Glu Ser Glu Gln Val Val Asp Leu Thr Leu Pro Lys Val 
        435                 440                 445             


Glu Ala Ile Lys Lys Arg Leu Gly Ser Leu Ala Asp Glu Phe Lys Glu 
    450                 455                 460                 


Leu Val Tyr Pro Pro Gly Tyr Asn Pro Glu Gly Lys Val Ala Lys Arg 
465                 470                 475                 480 


Lys Gln Asp Asp Glu Gly Ser Thr Ser Lys Lys Pro Lys Val Glu Leu 
                485                 490                 495     


Ser Glu Glu Glu Leu Lys Ala His Phe Arg Lys Gly Thr Leu Gly Lys 
            500                 505                 510         


Leu Thr Val Pro Thr Leu Lys Asp Ile Cys Lys Ala His Gly Leu Lys 
        515                 520                 525             


Ser Gly Pro Lys Lys Gln Glu Leu Leu Asp Ala Leu Ile Arg His Leu 
    530                 535                 540                 


Glu Lys Asn 
545         


<210>  4
<211>  306
<212>  PRT
<213>  Mus musculus

<400>  4

Met Glu Asp Leu Arg Gln Tyr Met Phe Ser Ser Leu Lys Asn Asn Lys 
1               5                   10                  15      


Lys Cys Thr Pro Thr Glu Ala Gln Leu Ser Ala Ile Asp Asp Leu Ile 
            20                  25                  30          


Asp Ser Met Ser Leu Val Lys Lys Asn Glu Glu Glu Asp Ile Val Glu 
        35                  40                  45              


Asp Leu Phe Pro Thr Ser Lys Ile Pro Asn Pro Glu Phe Gln Arg Leu 
    50                  55                  60                  


Tyr Gln Cys Leu Leu His Arg Ala Leu His Leu Gln Glu Arg Leu Pro 
65                  70                  75                  80  


Pro Ile Gln Gln His Ile Leu Asn Met Leu Asp Pro Pro Thr Glu Met 
                85                  90                  95      


Lys Ala Lys Cys Glu Ser Pro Leu Ser Lys Val Lys Thr Leu Phe Pro 
            100                 105                 110         


Leu Thr Glu Val Ile Lys Lys Lys Asn Gln Val Thr Ala Gln Asp Val 
        115                 120                 125             


Phe Gln Asp Asn His Glu Glu Gly Pro Ala Ala Lys Lys Tyr Lys Thr 
    130                 135                 140                 


Glu Lys Glu Glu Asp His Ile Ser Ile Ser Ser Leu Ala Glu Gly Asn 
145                 150                 155                 160 


Ile Thr Lys Val Gly Ser Val Asn Pro Val Glu Asn Phe Arg Phe Leu 
                165                 170                 175     


Val Arg Gln Lys Ile Ala Ser Phe Glu Glu Ala Ser Leu Gln Leu Ile 
            180                 185                 190         


Ser His Ile Glu Gln Phe Leu Asp Thr Asn Glu Thr Leu Tyr Phe Met 
        195                 200                 205             


Lys Ser Met Asp Cys Ile Lys Ala Phe Arg Glu Glu Ala Ile Gln Phe 
    210                 215                 220                 


Ser Glu Glu Gln Arg Phe Asn Ser Phe Leu Glu Ala Leu Arg Glu Lys 
225                 230                 235                 240 


Val Glu Ile Lys Gln Leu Asn His Phe Trp Glu Ile Val Val Gln Asp 
                245                 250                 255     


Gly Val Thr Leu Ile Thr Lys Asp Glu Gly Pro Gly Ser Ser Ile Thr 
            260                 265                 270         


Ala Glu Glu Ala Thr Lys Phe Leu Ala Pro Lys Asp Lys Ala Lys Glu 
        275                 280                 285             


Asp Thr Thr Gly Pro Glu Glu Ala Gly Asp Val Asp Asp Leu Leu Asp 
    290                 295                 300                 


Met Ile 
305     


<210>  5
<211>  199
<212>  PRT
<213>  Clostridium spec. 7_2_43 FAA

<400>  5

Glu Gly Ile Lys Ser Asn Ile Ser Leu Leu Lys Asp Glu Leu Arg Gly 
1               5                   10                  15      


Gln Ile Ser His Ile Ser His Glu Tyr Leu Ser Leu Ile Asp Leu Ala 
            20                  25                  30          


Phe Asp Ser Lys Gln Asn Arg Leu Phe Glu Met Lys Val Leu Glu Leu 
        35                  40                  45              


Leu Val Asn Glu Tyr Gly Phe Lys Gly Arg His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ile Val Tyr Ser Thr Thr Leu Glu Asp Asn Phe Gly 
65                  70                  75                  80  


Ile Ile Val Asp Thr Lys Ala Tyr Ser Glu Gly Tyr Ser Leu Pro Ile 
                85                  90                  95      


Ser Gln Ala Asp Glu Met Glu Arg Tyr Val Arg Glu Asn Ser Asn Arg 
            100                 105                 110         


Asp Glu Glu Val Asn Pro Asn Lys Trp Trp Glu Asn Phe Ser Glu Glu 
        115                 120                 125             


Val Lys Lys Tyr Tyr Phe Val Phe Ile Ser Gly Ser Phe Lys Gly Lys 
    130                 135                 140                 


Phe Glu Glu Gln Leu Arg Arg Leu Ser Met Thr Thr Gly Val Asn Gly 
145                 150                 155                 160 


Ser Ala Val Asn Val Val Asn Leu Leu Leu Gly Ala Glu Lys Ile Arg 
                165                 170                 175     


Ser Gly Glu Met Thr Ile Glu Glu Leu Glu Arg Ala Met Phe Asn Asn 
            180                 185                 190         


Ser Glu Phe Ile Leu Lys Tyr 
        195                 


<210>  6
<211>  597
<212>  DNA
<213>  Clostridium spec. 7_2_43 FAA

<400>  6
gaaggcatca aaagcaacat ctccctcctg aaagacgaac tccgggggca gattagccac       60

attagtcacg aatacctctc cctcatcgac ctggctttcg atagcaagca gaacaggctc      120

tttgagatga aagtgctgga actgctcgtc aatgagtacg ggttcaaggg tcgacacctc      180

ggcggatcta ggaaaccaga cggcatcgtg tatagtacca cactggaaga caactttggg      240

atcattgtgg ataccaaggc atactctgag ggttatagtc tgcccatttc acaggccgac      300

gagatggaac ggtacgtgcg cgagaactca aatagagatg aggaagtcaa ccctaacaag      360

tggtgggaga acttctctga ggaagtgaag aaatactact tcgtctttat cagcgggtcc      420

ttcaagggta aatttgagga acagctcagg agactgagca tgactaccgg cgtgaatggc      480

agcgccgtca acgtggtcaa tctgctcctg ggcgctgaaa agattcggag cggagagatg      540

accatcgaag agctggagag ggcaatgttt aataatagcg agtttatcct gaaatac         597


<210>  7
<211>  587
<212>  PRT
<213>  Clostridium spec. 7_2_43 FAA

<400>  7

Met Ile Asn Ile Ile Asp Val Asn Asn Lys Thr Ile Arg Thr Phe Gly 
1               5                   10                  15      


Trp Val Gln Asn Pro Ser Asn Phe Glu Ser Leu Lys Lys Val Val Ala 
            20                  25                  30          


Ile Phe Asp Asn Thr Ser Lys Thr Tyr Asn Glu Leu Lys Asp Lys Lys 
        35                  40                  45              


Ile Lys Lys Leu Val Asp Glu Arg Asp Gly Gln Lys Glu Leu Leu Asn 
    50                  55                  60                  


Ala Leu Asn Ala Asn Pro Leu Lys Ile Lys Tyr Cys Asn Leu Val Gly 
65                  70                  75                  80  


Thr Ser Phe Thr Pro Arg Ser Ser Ala Arg Cys Asn Gly Ile Val Gln 
                85                  90                  95      


Ala Thr Val Lys Gly Gln Arg Lys Glu Phe Ile Asp Asp Trp Ser Ser 
            100                 105                 110         


Asp Asn Phe Val Arg Trp Ala His Ala Leu Gly Phe Ile Lys Tyr Asn 
        115                 120                 125             


Tyr Asp Thr Asp Thr Phe Glu Ile Thr Asp Val Gly Arg Lys Tyr Val 
    130                 135                 140                 


Gln Ser Glu Asp Asp Ser Asn Glu Glu Ser Thr Ile Leu Glu Glu Ala 
145                 150                 155                 160 


Met Leu Ser Tyr Pro Pro Val Ala Arg Val Leu Thr Leu Leu Ser Asn 
                165                 170                 175     


Gly Glu His Leu Thr Lys Tyr Glu Ile Gly Lys Lys Leu Gly Phe Val 
            180                 185                 190         


Gly Glu Ala Gly Phe Thr Ser Leu Pro Leu Asn Val Leu Ile Met Thr 
        195                 200                 205             


Leu Ala Thr Thr Asp Glu Pro Lys Glu Lys Asn Lys Ile Lys Thr Asp 
    210                 215                 220                 


Trp Asp Gly Ser Ser Asp Lys Tyr Ala Arg Met Ile Ser Gly Trp Leu 
225                 230                 235                 240 


Val Lys Leu Gly Leu Leu Val Gln Arg Pro Lys Leu Val Thr Val Asp 
                245                 250                 255     


Phe Gly Gly Glu Leu Tyr Ser Glu Thr Ile Gly His Ala Tyr Met Ile 
            260                 265                 270         


Thr Asp Arg Gly Leu Lys Ala Val Arg Arg Leu Leu Gly Ile Asn Lys 
        275                 280                 285             


Val Ala Arg Val Ser Lys Asn Val Phe Trp Glu Met Leu Ala Thr Lys 
    290                 295                 300                 


Gly Ile Asp Lys Asn Tyr Ile Arg Thr Arg Arg Ala Tyr Ile Leu Lys 
305                 310                 315                 320 


Ile Leu Ile Glu Ser Asn Lys Val Leu Thr Leu Glu Asp Ile Lys Gly 
                325                 330                 335     


Lys Leu Lys Leu Ala Ser Ile Asn Glu Ser Ile Asn Thr Ile Lys Asp 
            340                 345                 350         


Asp Ile Asn Gly Leu Ile Asn Thr Gly Ile Asn Ile Lys Ser Glu Thr 
        355                 360                 365             


Thr Gly Tyr Lys Ile Tyr Asp Ser Ile Asn Asp Phe Ile Ile Pro Lys 
    370                 375                 380                 


Thr Gly Asp Thr Glu Gly Ile Lys Ser Asn Ile Ser Leu Leu Lys Asp 
385                 390                 395                 400 


Glu Leu Arg Gly Gln Ile Ser His Ile Ser His Glu Tyr Leu Ser Leu 
                405                 410                 415     


Ile Asp Leu Ala Phe Asp Ser Lys Gln Asn Arg Leu Phe Glu Met Lys 
            420                 425                 430         


Val Leu Glu Leu Leu Val Asn Glu Tyr Gly Phe Lys Gly Arg His Leu 
        435                 440                 445             


Gly Gly Ser Arg Lys Pro Asp Gly Ile Val Tyr Ser Thr Thr Leu Glu 
    450                 455                 460                 


Asp Asn Phe Gly Ile Ile Val Asp Thr Lys Ala Tyr Ser Glu Gly Tyr 
465                 470                 475                 480 


Ser Leu Pro Ile Ser Gln Ala Asp Glu Met Glu Arg Tyr Val Arg Glu 
                485                 490                 495     


Asn Ser Asn Arg Asp Glu Glu Val Asn Pro Asn Lys Trp Trp Glu Asn 
            500                 505                 510         


Phe Ser Glu Glu Val Lys Lys Tyr Tyr Phe Val Phe Ile Ser Gly Ser 
        515                 520                 525             


Phe Lys Gly Lys Phe Glu Glu Gln Leu Arg Arg Leu Ser Met Thr Thr 
    530                 535                 540                 


Gly Val Asn Gly Ser Ala Val Asn Val Val Asn Leu Leu Leu Gly Ala 
545                 550                 555                 560 


Glu Lys Ile Arg Ser Gly Glu Met Thr Ile Glu Glu Leu Glu Arg Ala 
                565                 570                 575     


Met Phe Asn Asn Ser Glu Phe Ile Leu Lys Tyr 
            580                 585         


<210>  8
<211>  6606
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Vector Rab38-cht

<400>  8
caccgcatta ccctgggcgt tgaaaccgaa gaagacctgg atttgaaata ggcgttttct       60

ttacatttct aaagtgggac tcctcacttg taaaaggaaa aataatgata cttttaagac      120

ttccaggatg actaaatggt gtgtatgaga agatttataa acatctgccg ctacttacaa      180

tgataagacc acttgtgtgt tgttcagctt ggagaattta ggataggagt ggaggctgaa      240

agaaaagtaa gcccttagca tttcctctca ggtggcctct actttaggtc attaacagtt      300

gaataggcgc taagagatag cattaccact ttatagaagc ccaggcaaaa ggagattaaa      360

gggtttgcct aaattctttc aactctaagg gccagagaag acctaagtct actgctttgc      420

tgtttctcaa ggtctcccca actttacaac actgtgtggg tggcaacagg gcttaatagc      480

ctcagaagac ctgggtattt ttcgacactc agttctctcc ccggcagaac gtggaaaaca      540

aaatccacat aagtttgtgt catggacggg aggcgagaga aaaatctctg tgaaaggagt      600

aaagcactgt gcaaatacca gcttgacagg cagtagcact ggggtcccgg gtcctttagc      660

ttccagtccc aggagttgct cttgtctcct cccactctgg agtccgcaga gtaggaagga      720

ggattaaacc cgggggagga gttccgcacc agctccctat cctgcgccag cacgcctagc      780

ctaagcgccc acatagagct ccggtctccg tcggtgccca gccccggctg tgcttcccag      840

agcaagctcc aggctccgca agacccgcgg gcctccagga tgcagacacc tcacaaggag      900

cacctgtaca agctgctggt gatcggcgac ctggtagtgg gcaagaccag cattatcaag      960

cgctatgtgc atcaaaattt ctcctcgcac tatcgagcca ccattggtgt ggacttcgcg     1020

ctgaaggtgc tccactggga cccagagacg gtggtgcgct tgcagctctg ggacattgct     1080

ggtgagcgat cagagcagcg cgcaacgggt gagggtggag tgagccagtg aggagttcgg     1140

gggtgaaggt tcggggagtg gaaaatgact tttcagtcgg ttccagtccc gggacccttg     1200

agtgcaatca agcaggagat ccggatcgcc tgggcgctcc actcttggaa agtttggctt     1260

aatggcttgg aaacctgatt tcaaagaaat ggaagtgttt tcttttcttt ctttcctttt     1320

tttttttttt ttttttcttt tgctgttgtt tctgttggag tcgtccccac tctacctgta     1380

acttctagat aacttcgctg gctctcactg gctgtgagaa agcgaaccac tttctcctgg     1440

gattcttggg tgcagagaag gctgtcgcct ggactcacaa ggagattgta gtcgcattct     1500

tgtttcattc tagtcctttt ctggacacag gtagccgcga cttggcccag agtatctcac     1560

gtggctttca tccttcgtgt ttagagggga agcccctagg aaatttaaga aggagcagga     1620

ttatcttagg aatttagttt ctttcaaatc tcactactat catctccttg cttattggcc     1680

tcttcagtca gaaaaatttg agatgctaaa tttgtataca tctagaacga actatctctt     1740

ctcactccac tcccctcttc cccatctctc ttccgtctcc ctccatcctt ggctatctct     1800

tcttcacttt ccatttcaaa caggagactg tgtatgtttt ttaggaaaac attaaaaaaa     1860

aaaccacaaa aacaaaaaca aaacggagac agggtcccgt catgtaactc tgctaaccta     1920

tatcaagctg accttgacct catagagacc cacttgcctc tgcctcccta gaggcaaggg     1980

tcggggttat ggtgatgtta atgtcgtttg ctttaagatt ccttgatttg atcttggtgt     2040

attttttgag aaatctaaag tatgaaatca gagtttgact aacagcttct accagctcct     2100

agccacaata aagactgagg caggctatag ttagtgctca atactgggtc ctacctggct     2160

gcttgtaacc tgggcatgcc tagcattcta gatgctaact caccaaagca gtagcatttt     2220

aagctgcaaa tggctaggca gcgacagctc aagaatcttc ttgctttgga gttttaaact     2280

ccaatgagat tttccatgat ccctttcaaa taaccctact taatctctct tcatagccca     2340

cagtaccaag aagcctttga taagctctgg attgaaaaga agcagttctt tttcaaaaga     2400

tgtgctcatt tgaactagtg catttccctg gaaacacttt gccaggactt gagatgggca     2460

ctaagaagga aaattcctca aaggacatgt acagtcttga gatgcattcg cttctgtagc     2520

catgagcttg ctggtcttga gataaggtta gttggtgtag ctaggttcat ggtttggagt     2580

ctttggcagt tctagagaag catgagctat tagagacttg gagattgcat caagtagagc     2640

cttttgagct tttcactgtg tacctgggcc ctctgtcgct gcacgtttta gtgtctgaaa     2700

tgtctttcag ctgtagcagt tttctcggga ccccagttta aaatagctta ctgtttaaaa     2760

gatgtagctg tagctagcat tattgaacta gcataattat agtctaaata gcattatgtc     2820

ttcagccttg ttatatgttg gtgagtttta gtttcctctt ctaaacggga agaacagaaa     2880

gatgtaatga ttctgagctt ccagagtgag acacctctag agagaaatac cttcttctga     2940

agactaccgt gtgattacag ataaattctg atatctttgt ttagcttttg atatctataa     3000

acagggagtg tattttatct ctccaaatga gagaagaata aacaataatg caaggtaaag     3060

gcaatagtgc tacactctag gagttaccac tctttgtaca tttatttata aatactaagc     3120

aagaggaaca tgccatacat acactgacta agtcctaaca agtggcagtt cttatatcac     3180

acatttatct tgccctcaaa tgccagtcca gcatcagttt agtctcatgc atttggcagc     3240

ataaggcagt ttgagttcca cacttgctct cagaagcaat ttaactccca cacttgggaa     3300

tcctttccta agccacagtt tcagaccaaa gttttggtga aggctataat cacagaagtc     3360

tgcacaagta gggagtctga aggatctgag ctccattcag cagtcagagc ggcatccaac     3420

cccaaggtaa tgctcagctc actttgataa cttcaagctc aaaggccctg aactgctgag     3480

ttggaggttg aaagatgttt gggtaaaagc aaggtaattg gcggatagga tggttgtaac     3540

gtaattgttt caagttgtat tagagacctc tgggttctaa ggggatatga aatccaacct     3600

ccactctcca ctgagattca agttaggtta agtatgcctt tgagtaccct caagtcacag     3660

catgccactc tccttttctt aactctaata tgtatctata aagaacgggt agtagtcaac     3720

tgagtcgacg gtatcgataa gcttgatcca gcttttgttc cctttagtga gggttaattg     3780

cgcgcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa     3840

ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga     3900

gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt     3960

gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct     4020

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat     4080

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     4140

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     4200

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     4260

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     4320

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     4380

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     4440

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     4500

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     4560

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc     4620

ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg aagccagtta     4680

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg     4740

gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt     4800

tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg     4860

tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta     4920

aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg     4980

aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg     5040

tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc     5100

gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg     5160

agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg     5220

aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag     5280

gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat     5340

caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc     5400

cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc     5460

ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa     5520

ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac     5580

gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt     5640

cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc     5700

gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa     5760

caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca     5820

tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat     5880

acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa     5940

aagtgccacc taaattgtaa gcgttaatat tttgttaaaa ttcgcgttaa atttttgtta     6000

aatcagctca ttttttaacc aataggccga aatcggcaaa atcccttata aatcaaaaga     6060

atagaccgag atagggttga gtgttgttcc agtttggaac aagagtccac tattaaagaa     6120

cgtggactcc aacgtcaaag ggcgaaaaac cgtctatcag ggcgatggcc cactacgtga     6180

accatcaccc taatcaagtt ttttggggtc gaggtgccgt aaagcactaa atcggaaccc     6240

taaagggagc ccccgattta gagcttgacg gggaaagccg gcgaacgtgg cgagaaagga     6300

agggaagaaa gcgaaaggag cgggcgctag ggcgctggca agtgtagcgg tcacgctgcg     6360

cgtaaccacc acacccgccg cgcttaatgc gccgctacag ggcgcgtccc attcgccatt     6420

caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat tacgccagct     6480

ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt tttcccagtc     6540

acgacgttgt aaaacgacgg ccagtgagcg cgcgtaatac gactcactat agggcgaatt     6600

ggagct                                                                6606


<210>  9
<211>  202
<212>  DNA
<213>  Mus musculus

<400>  9
atgcagacac ctcacaagga gcacctgtac aagctgctgg tgatcggcga cctgggtgtg       60

ggcaagacca gcattatcaa gcgctatgtg caccaaaact tctcctcgca ctaccgggcc      120

accattggtg tggacttcgc gctgaaggtg ctccactggg acccagagac ggtggtgcgc      180

ttgcagctct gggacattgc tg                                               202


<210>  10
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer RabCht-1

<400>  10
ctcaccgcat taccctgggc gttgaaaccg aagaagacc                              39


<210>  11
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer RabCht-2

<400>  11
gataatgctg gtcttgccca ctaccaggtc gccgatc                                37


<210>  12
<211>  82
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer RabCht-3

<400>  12
gtgggcaaga ccagcattat caagcgctat gtgcatcaaa atttctcctc gcactatcga       60

gccaccattg gtgtggactt cg                                                82


<210>  13
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer RabCht-4

<400>  13
gcttatcgat accgtcgact cagttgacta ctacccgttc                             40


<210>  14
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer cht-Ex1F

<400>  14
ggcctccagg atgcagacac c                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer cht Ex1R

<400>  15
ccagcaatgt cccagagctg c                                                 21


<210>  16
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer lig4-1

<400>  16
gactacgcgt gtaaacaaag tttccaatgt atttg                                  35


<210>  17
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer lig4-2

<400>  17
acgtacgcgt gcggccgcct aaagcaaata ctggttttcc                             40


<210>  18
<211>  6569
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCAG-venus-lig4-bpA

<400>  18
gggtaccggg ccccccctcg aggtcgacgg tatcgataag cttgatatcg aattcgagct       60

cggtacccgg gggcgcgccg gatctcgaca ttgattattg actagttatt aatagtaatc      120

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt      180

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta      240

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg actatttacg      300

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      360

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt      420

tcctacttgg cagtacatct acgtattagt catcgctatt accatgggtc gaggtgagcc      480

ccacgttctg cttcactctc cccatctccc ccccctcccc acccccaatt ttgtatttat      540

ttatttttta attattttgt gcagcgatgg gggcgggggg ggggggggcg cgcgccaggc      600

ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga gaggtgcggc ggcagccaat      660

cagagcggcg cgctccgaaa gtttcctttt atggcgaggc ggcggcggcg gcggccctat      720

aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc cttcgccccg tgccccgctc      780

cgcgccgcct cgcgccgccc gccccggctc tgactgaccg cgttactccc acaggtgagc      840

gggcgggacg gcccttctcc tccgggctgt aattagcgct tggtttaatg acggctcgtt      900

tcttttctgt ggctgcgtga aagccttaaa gggctccggg agggcccttt gtgcgggggg      960

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggcccgcg     1020

ctgcccggcg gctgtgagcg ctgcgggcgc ggcgcggggc tttgtgcgct ccgcgtgtgc     1080

gcgaggggag cgcggccggg ggcggtgccc cgcggtgcgg gggggctgcg aggggaacaa     1140

aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg ggtgtgggcg cggcggtcgg     1200

gctgtaaccc ccccctgcac ccccctcccc gagttgctga gcacggcccg gcttcgggtg     1260

cggggctccg tgcggggcgt ggcgcggggc tcgccgtgcc gggcgggggg tggcggcagg     1320

tgggggtgcc gggcggggcg gggccgcctc gggccgggga gggctcgggg gaggggcgcg     1380

gcggccccgg agcgccggcg gctgtcgagg cgcggcgagc cgcagccatt gccttttatg     1440

gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa atctggcgga gccgaaatct     1500

gggaggcgcc gccgcacccc ctctagcggg cgcgggcgaa gcggtgcggc gccggcagga     1560

aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt ctccatctcc     1620

agcctcgggg ctgccgcagg gggacggctg ccttcggggg ggacggggca gggcggggtt     1680

cggcttctgg cgtgtgaccg gcggctctag agcctctgct aaccatgttc atgccttctt     1740

ctttttccta cagatcctta attaataata cgactcacta taggggccgc caccatgccc     1800

aagaagaaga ggaaggtgat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc     1860

atcctggtcg agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc     1920

gagggcgatg ccacctacgg caagctgacc ctgaagctga tctgcaccac cggcaagctg     1980

cccgtgccct ggcccaccct cgtgaccacc ctgggctacg gcctgcagtg cttcgcccgc     2040

taccccgacc acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc     2100

caggagcgca ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag     2160

ttcgagggcg acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac     2220

ggcaacatcc tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcacc     2280

gccgacaagc agaagaacgg catcaaggcc aacttcaaga tccgccacaa catcgaggac     2340

ggcggcgtgc agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg     2400

ctgctgcccg acaaccacta cctgagctac cagtccgccc tgagcaaaga ccccaacgag     2460

aagcgcgatc acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg     2520

gacgagctgt acaagggcgg aggcggaggc ggaggcacgc gtgtaaacaa agtttccaat     2580

gtatttgaag atgttgagtt ttgtgttatg agtggattag atggttatcc aaaggctgac     2640

ctagagaaca gaattgcaga attcggtggt tatatagtac agaatccagg cccggataca     2700

tactgtgtta ttgcaggttc tgagaacgtt agagtgaaaa acattatttc ttcagataaa     2760

aatgatgttg tcaagcccga gtggctttta gagtgtttta agacaaaaac atgcgtgccg     2820

tggcaacctc gctttatgat tcacatgtgc ccgtcgacaa agcagcattt tgcccgtgag     2880

tatgactgct atggtgatag ctattttgtt gacacagatt tggatcaatt gaaagaagtg     2940

tttctaggaa ttaaacccag tgagcagcag actcctgaag aaatggcccc tgtgattgct     3000

gacttagaat gtcgttattc ctgggaccac tctcctctca gtatgtttcg acattacacc     3060

atttatttgg acttgtatgc tgttattaat gacttgagtt ccagaattga agccacgaga     3120

ttaggtatta cagcccttga gctgcggttt catggagcaa aggtggtttc ctgcttatct     3180

gaaggggtat ctcatgttat cattggggag gatcagagac gagttactga ctttaaaata     3240

ttcagaagaa tgcttaagaa aaagtttaaa atcctgcaag aaagttgggt gtccgattca     3300

gtagacaagg gcgaactgca ggaggaaaac cagtatttgc tttaggcggc cgcacgcgta     3360

aatgattgca gatccactag ttctagagct cgctgatcag cctcgactgt gccttctagt     3420

tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact     3480

cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat     3540

tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc     3600

aggcatgctg gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc     3660

tcgagatcca ctagttctag cctcgaggct agagcggccg ccaccgcggt ggagctccaa     3720

ttcgccctat agtgagtcgt attacgcgcg ctcactggcc gtcgttttac aacgtcgtga     3780

ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc ctttcgccag     3840

ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc gcagcctgaa     3900

tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     3960

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc     4020

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg     4080

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc     4140

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt     4200

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc     4260

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta     4320

acaaaaattt aacgcgaatt ttaacaaaat attaacgctt acaatttagg tggcactttt     4380

cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat     4440

ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg     4500

agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt     4560

tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga     4620

gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa     4680

gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt     4740

attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt     4800

gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc     4860

agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga     4920

ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat     4980

cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct     5040

gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc     5100

cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg     5160

gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg tgggtctcgc     5220

ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg     5280

acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca     5340

ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta gattgattta     5400

aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc     5460

aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa     5520

ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca     5580

ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta     5640

actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc     5700

caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca     5760

gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta     5820

ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag     5880

cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt     5940

cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc     6000

acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac     6060

ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac     6120

gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc     6180

tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat     6240

accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcggaagag     6300

cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg cagctggcac     6360

gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt gagttagctc     6420

actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt gtgtggaatt     6480

gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacgc caagcgcgca     6540

attaaccctc actaaaggga acaaaagct                                       6569


<210>  19
<211>  56
<212>  PRT
<213>  Mus musculus

<400>  19

Asp Cys Tyr Gly Asp Ser Tyr Phe Val Asp Thr Asp Leu Asp Gln Leu 
1               5                   10                  15      


Lys Glu Val Phe Leu Gly Ile Lys Pro Ser Glu Gln Gln Thr Pro Glu 
            20                  25                  30          


Glu Met Ala Pro Val Ile Ala Asp Leu Glu Cys Arg Tyr Ser Trp Asp 
        35                  40                  45              


His Ser Pro Leu Ser Met Phe Arg 
    50                  55      


<210>  20
<211>  5906
<212>  DNA
<213>  Artificial sequence

<220>
<223>  plasmid pCAG-E4ORF6-bpA

<400>  20
gggtaccggg ccccccctcg aggtcgacgg tatcgataag cttgatatcg aattcgagct       60

cggtacccgg gggcgcgccg gatctcgaca ttgattattg actagttatt aatagtaatc      120

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt      180

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta      240

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg actatttacg      300

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      360

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt      420

tcctacttgg cagtacatct acgtattagt catcgctatt accatgggtc gaggtgagcc      480

ccacgttctg cttcactctc cccatctccc ccccctcccc acccccaatt ttgtatttat      540

ttatttttta attattttgt gcagcgatgg gggcgggggg ggggggggcg cgcgccaggc      600

ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga gaggtgcggc ggcagccaat      660

cagagcggcg cgctccgaaa gtttcctttt atggcgaggc ggcggcggcg gcggccctat      720

aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc cttcgccccg tgccccgctc      780

cgcgccgcct cgcgccgccc gccccggctc tgactgaccg cgttactccc acaggtgagc      840

gggcgggacg gcccttctcc tccgggctgt aattagcgct tggtttaatg acggctcgtt      900

tcttttctgt ggctgcgtga aagccttaaa gggctccggg agggcccttt gtgcgggggg      960

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggcccgcg     1020

ctgcccggcg gctgtgagcg ctgcgggcgc ggcgcggggc tttgtgcgct ccgcgtgtgc     1080

gcgaggggag cgcggccggg ggcggtgccc cgcggtgcgg gggggctgcg aggggaacaa     1140

aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg ggtgtgggcg cggcggtcgg     1200

gctgtaaccc ccccctgcac ccccctcccc gagttgctga gcacggcccg gcttcgggtg     1260

cggggctccg tgcggggcgt ggcgcggggc tcgccgtgcc gggcgggggg tggcggcagg     1320

tgggggtgcc gggcggggcg gggccgcctc gggccgggga gggctcgggg gaggggcgcg     1380

gcggccccgg agcgccggcg gctgtcgagg cgcggcgagc cgcagccatt gccttttatg     1440

gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa atctggcgga gccgaaatct     1500

gggaggcgcc gccgcacccc ctctagcggg cgcgggcgaa gcggtgcggc gccggcagga     1560

aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt ctccatctcc     1620

agcctcgggg ctgccgcagg gggacggctg ccttcggggg ggacggggca gggcggggtt     1680

cggcttctgg cgtgtgaccg gcggctctag agcctctgct aaccatgttc atgccttctt     1740

ctttttccta cagatcctta attaataata cgactcacta taggggccgc caccatgact     1800

acgtccggcg ttccatttgg catgacacta cgaccaacac gatctcggtt gtctcggcgc     1860

actccgtaca gtagggatcg cctacctcct tttgagacag agacccgcgc taccatactg     1920

gaggatcatc cgctgctgcc cgaatgtaac actttgacaa tgcacaacgt gagttacgtg     1980

cgaggtcttc cctgcagtgt gggatttacg ctgattcagg aatgggttgt tccctgggat     2040

atggttctga cgcgggagga gcttgtaatc ctgaggaagt gtatgcacgt gtgcctgtgt     2100

tgtgccaaca ttgatatcat gacgagcatg atgatccatg gttacgagtc ctgggctctc     2160

cactgtcatt gttccagtcc cggttccctg cagtgcatag ccggcgggca ggttttggcc     2220

agctggttta ggatggtggt ggatggcgcc atgtttaatc agaggtttat atggtaccgg     2280

gaggtggtga attacaacat gccaaaagag gtaatgttta tgtccagcgt gtttatgagg     2340

ggtcgccact taatctacct gcgcttgtgg tatgatggcc acgtgggttc tgtggtcccc     2400

gccatgagct ttggatacag cgccttgcac tgtgggattt tgaacaatat tgtggtgctg     2460

tgctgcagtt actgtgctga tttaagtgag atcagggtgc gctgctgtgc ccggaggaca     2520

aggcgtctca tgctgcgggc ggtgcgaatc atcgctgagg agaccactgc catgttgtat     2580

tcctgcagga cggagcggcg gcggcagcag tttattcgcg cgctgctgca gcaccaccgc     2640

cctatcctga tgcacgatta tgactctacc cccatgtagt aggcggccgc acgcgtaaat     2700

gattgcagat ccactagttc tagagctcgc tgatcagcct cgactgtgcc ttctagttgc     2760

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     2820

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     2880

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     2940

catgctgggg atgcggtggg ctctatggct tctgaggcgg aaagaaccag ctggggctcg     3000

agatccacta gttctagcct cgaggctaga gcggccgcca ccgcggtgga gctccaattc     3060

gccctatagt gagtcgtatt acgcgcgctc actggccgtc gttttacaac gtcgtgactg     3120

ggaaaaccct ggcgttaccc aacttaatcg ccttgcagca catccccctt tcgccagctg     3180

gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg     3240

cgaatgggac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag     3300

cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct tcccttcctt     3360

tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt     3420

ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg atggttcacg     3480

tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt     3540

taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg tctattcttt     3600

tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc tgatttaaca     3660

aaaatttaac gcgaatttta acaaaatatt aacgcttaca atttaggtgg cacttttcgg     3720

ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg     3780

ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt     3840

attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt     3900

gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg     3960

ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa     4020

cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt     4080

gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag     4140

tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt     4200

gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga     4260

ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt     4320

tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta     4380

gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg     4440

caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc     4500

cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt     4560

atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg     4620

gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg     4680

attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa     4740

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa     4800

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga     4860

tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg     4920

ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact     4980

ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac     5040

cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg     5100

gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg     5160

gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga     5220

acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc     5280

gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg     5340

agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc     5400

tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc     5460

agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt     5520

cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc     5580

gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc     5640

ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag ctggcacgac     5700

aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact     5760

cattaggcac cccaggcttt acactttatg cttccggctc gtatgttgtg tggaattgtg     5820

agcggataac aatttcacac aggaaacagc tatgaccatg attacgccaa gcgcgcaatt     5880

aaccctcact aaagggaaca aaagct                                          5906


<210>  21
<211>  6512
<212>  DNA
<213>  Artificial sequence

<220>
<223>  plasmid pCAG-E1b55K-bpA

<400>  21
gggtaccggg ccccccctcg aggtcgacgg tatcgataag cttgatatcg aattcgagct       60

cggtacccgg gggcgcgccg gatctcgaca ttgattattg actagttatt aatagtaatc      120

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt      180

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta      240

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg actatttacg      300

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      360

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt      420

tcctacttgg cagtacatct acgtattagt catcgctatt accatgggtc gaggtgagcc      480

ccacgttctg cttcactctc cccatctccc ccccctcccc acccccaatt ttgtatttat      540

ttatttttta attattttgt gcagcgatgg gggcgggggg ggggggggcg cgcgccaggc      600

ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga gaggtgcggc ggcagccaat      660

cagagcggcg cgctccgaaa gtttcctttt atggcgaggc ggcggcggcg gcggccctat      720

aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc cttcgccccg tgccccgctc      780

cgcgccgcct cgcgccgccc gccccggctc tgactgaccg cgttactccc acaggtgagc      840

gggcgggacg gcccttctcc tccgggctgt aattagcgct tggtttaatg acggctcgtt      900

tcttttctgt ggctgcgtga aagccttaaa gggctccggg agggcccttt gtgcgggggg      960

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggcccgcg     1020

ctgcccggcg gctgtgagcg ctgcgggcgc ggcgcggggc tttgtgcgct ccgcgtgtgc     1080

gcgaggggag cgcggccggg ggcggtgccc cgcggtgcgg gggggctgcg aggggaacaa     1140

aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg ggtgtgggcg cggcggtcgg     1200

gctgtaaccc ccccctgcac ccccctcccc gagttgctga gcacggcccg gcttcgggtg     1260

cggggctccg tgcggggcgt ggcgcggggc tcgccgtgcc gggcgggggg tggcggcagg     1320

tgggggtgcc gggcggggcg gggccgcctc gggccgggga gggctcgggg gaggggcgcg     1380

gcggccccgg agcgccggcg gctgtcgagg cgcggcgagc cgcagccatt gccttttatg     1440

gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa atctggcgga gccgaaatct     1500

gggaggcgcc gccgcacccc ctctagcggg cgcgggcgaa gcggtgcggc gccggcagga     1560

aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt ctccatctcc     1620

agcctcgggg ctgccgcagg gggacggctg ccttcggggg ggacggggca gggcggggtt     1680

cggcttctgg cgtgtgaccg gcggctctag agcctctgct aaccatgttc atgccttctt     1740

ctttttccta cagatcctta attaataata cgactcacta taggggccgc caccatggag     1800

cgaagaaacc catctgagcg gggggtacct gctggatttt ctggccatgc atctgtggag     1860

agcggttgtg agacacaaga atcgcctgct actgttgtct tccgtccgcc cggcgataat     1920

accgacggag gagcagcagc agcagcagga ggaagccagg cggcggcggc aggagcagag     1980

cccatggaac ccgagagccg gcctggaccc tcgggaatga atgttgtaca ggtggctgaa     2040

ctgtatccag aactgagacg cattttgaca attacagagg atgggcaggg gctaaagggg     2100

gtaaagaggg agcggggggc ttgtgaggct acagaggagg ctaggaatct agcttttagc     2160

ttaatgacca gacaccgtcc tgagtgtatt acttttcaac agatcaagga taattgcgct     2220

aatgagcttg atctgctggc gcagaagtat tccatagagc agctgaccac ttactggctg     2280

cagccagggg atgattttga ggaggctatt agggtatatg caaaggtggc acttaggcca     2340

gattgcaagt acaagatcag caaacttgta aatatcagga attgttgcta catttctggg     2400

aacggggccg aggtggagat agatacggag gatagggtgg cctttagatg tagcatgata     2460

aatatgtggc cgggggtgct tggcatggac ggggtggtta ttatgaatgt aaggtttact     2520

ggccccaatt ttagcggtac ggttttcctg gccaatacca accttatcct acacggtgta     2580

agcttctatg ggtttaacaa tacctgtgtg gaagcctgga ccgatgtaag ggttcggggc     2640

tgtgcctttt actgctgctg gaagggggtg gtgtgtcgcc ccaaaagcag ggcttcaatt     2700

aagaaatgcc tctttgaaag gtgtaccttg ggtatcctgt ctgagggtaa ctccagggtg     2760

cgccacaatg tggcctccga ctgtggttgc ttcatgctag tgaaaagcgt ggctgtgatt     2820

aagcataaca tggtatgtgg caactgcgag gacagggcct ctcagatgct gacctgctcg     2880

gacggcaact gtcacctgct gaagaccatt cacgtagcca gccactctcg caaggcctgg     2940

ccagtgtttg agcataacat actgacccgc tgttccttgc atttgggtaa caggaggggg     3000

gtgttcctac cttaccaatg caatttgagt cacactaaga tattgcttga gcccgagagc     3060

atgtccaagg tgaacctgaa cggggtgttt gacatgacca tgaagatctg gaaggtgctg     3120

aggtacgatg agacccgcac caggtgcaga ccctgcgagt gtggcggtaa acatattagg     3180

aaccagcctg tgatgctgga tgtgaccgag gagctgaggc ccgatcactt ggtgctggcc     3240

tgcacccgcg ctgagtttgg ctctagcgat gaagatacag attgataggc ggccgcacgc     3300

gtaaatgatt gcagatccac tagttctaga gctcgctgat cagcctcgac tgtgccttct     3360

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3420

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3480

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3540

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     3600

ggctcgagat ccactagttc tagcctcgag gctagagcgg ccgccaccgc ggtggagctc     3660

caattcgccc tatagtgagt cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg     3720

tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc cccctttcgc     3780

cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct     3840

gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac     3900

gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc     3960

ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt     4020

agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg     4080

ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac     4140

gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta     4200

ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat     4260

ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt aggtggcact     4320

tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg     4380

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     4440

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     4500

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     4560

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     4620

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     4680

cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     4740

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     4800

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     4860

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     4920

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     4980

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     5040

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     5100

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     5160

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     5220

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     5280

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     5340

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     5400

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     5460

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     5520

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     5580

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     5640

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     5700

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     5760

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     5820

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     5880

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     5940

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     6000

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     6060

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     6120

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     6180

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa     6240

gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg     6300

cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa tgtgagttag     6360

ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat gttgtgtgga     6420

attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta cgccaagcgc     6480

gcaattaacc ctcactaaag ggaacaaaag ct                                   6512


<210>  22
<211>  66
<212>  DNA
<213>  Artificial sequence

<220>
<223>  >primerE4-1

<400>  22
gatcttaatt aataatacga ctcactatag gggccgccac catgactacg tccggcgttc       60

catttg                                                                  66


<210>  23
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  >primerE4-2

<400>  23
gatcacgcgt gcggccgcct actacatggg ggtagagtca taatcg                      46


<210>  24
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  >primerE1b-1

<400>  24
gatcttaatt aataatacga ctcactatag gggccgccac catggagcga agaaacccat       60

ctg                                                                     63


<210>  25
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  >primerE1b-2

<400>  25
gatcacgcgt gcggccgcct atcaatctgt atcttcatcg ctagag                      46


<210>  26
<211>  6684
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCAG-Ku70(62-609)-bpA

<400>  26
gggtaccggg ccccccctcg aggtcgacgg tatcgataag cttgatatcg aattcgagct       60

cggtacccgg gggcgcgccg gatctcgaca ttgattattg actagttatt aatagtaatc      120

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt      180

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta      240

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg actatttacg      300

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      360

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt      420

tcctacttgg cagtacatct acgtattagt catcgctatt accatgggtc gaggtgagcc      480

ccacgttctg cttcactctc cccatctccc ccccctcccc acccccaatt ttgtatttat      540

ttatttttta attattttgt gcagcgatgg gggcgggggg ggggggggcg cgcgccaggc      600

ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga gaggtgcggc ggcagccaat      660

cagagcggcg cgctccgaaa gtttcctttt atggcgaggc ggcggcggcg gcggccctat      720

aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc cttcgccccg tgccccgctc      780

cgcgccgcct cgcgccgccc gccccggctc tgactgaccg cgttactccc acaggtgagc      840

gggcgggacg gcccttctcc tccgggctgt aattagcgct tggtttaatg acggctcgtt      900

tcttttctgt ggctgcgtga aagccttaaa gggctccggg agggcccttt gtgcgggggg      960

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggcccgcg     1020

ctgcccggcg gctgtgagcg ctgcgggcgc ggcgcggggc tttgtgcgct ccgcgtgtgc     1080

gcgaggggag cgcggccggg ggcggtgccc cgcggtgcgg gggggctgcg aggggaacaa     1140

aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg ggtgtgggcg cggcggtcgg     1200

gctgtaaccc ccccctgcac ccccctcccc gagttgctga gcacggcccg gcttcgggtg     1260

cggggctccg tgcggggcgt ggcgcggggc tcgccgtgcc gggcgggggg tggcggcagg     1320

tgggggtgcc gggcggggcg gggccgcctc gggccgggga gggctcgggg gaggggcgcg     1380

gcggccccgg agcgccggcg gctgtcgagg cgcggcgagc cgcagccatt gccttttatg     1440

gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa atctggcgga gccgaaatct     1500

gggaggcgcc gccgcacccc ctctagcggg cgcgggcgaa gcggtgcggc gccggcagga     1560

aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt ctccatctcc     1620

agcctcgggg ctgccgcagg gggacggctg ccttcggggg ggacggggca gggcggggtt     1680

cggcttctgg cgtgtgaccg gcggctctag agcctctgct aaccatgttc atgccttctt     1740

ctttttccta cagatcctta attaataata cgactcacta taggggccgc caccatgccc     1800

aagaagaaga ggaaggtgat ccagtgtatc cagagtgtgt acaccagtaa gatcataagc     1860

agcgatcggg atctcctggc agtggtgttc tatggaaccg agaaagataa aaattcagtg     1920

aatttcaaaa atatttatgt cttacaagat ttggacaacc caggcgctaa gcgagtgcta     1980

gagctcgacc agtttaaggg acaacagggg aagaagcact tccgagacac ggttggccat     2040

gggtctgact actctttgag tgaagtgctc tgggtctgtg ccaacctctt cagcgacgtc     2100

cagctcaaga tgagtcacaa gaggatcatg ctgttcacca atgaagacga cccccatggc     2160

cgtgacagtg ctaaagccag ccgggccagg accaaagcca gcgacctccg ggacactggg     2220

atcttccttg acttgatgca tctgaagaag ccaggaggct ttgatgtatc cgtgttctac     2280

agggacatca tcaccaccgc tgaggacgag gaccttgggg ttcacttcga ggagtcaagc     2340

aagctggaag acctgctaag gaaggttcga gccaaggaga ccaaaaagcg agttctgtcc     2400

aggttaaagt ttaagctcgg tgaagacgta gtactcatgg tgggcattta taacttggtc     2460

cagaaagcta acaagccttt tccagtgaga ctctatcggg aaacaaatga accagtgaaa     2520

accaagacaa ggacttttaa tgtaaacacc ggcagtctac tcctgcctag tgacaccaag     2580

cggtctctga cttacgggac acgtcagatt gtgctggaga aagaggagac agaggagctg     2640

aagcggtttg atgagccagg tttgatcctc atgggcttta agcccacggt gatgctgaag     2700

aagcagcact acctgaggcc ctctctgttc gtgtacccag aggagtccct ggtcagtggg     2760

agctcaacct tgttcagcgc tctgctcacc aagtgtgtgg agaagaaggt catagcagtg     2820

tgtagataca caccccggaa gaacgtctcc ccgtattttg tggctttggt gccccaggaa     2880

gaggagctgg atgatcagaa cattcaggtg actccaggag gcttccagct tgtcttcctc     2940

ccttatgccg atgacaagcg gaaggtgccc tttactgaga aggtgacggc caaccaggag     3000

cagatagaca agatgaaggc cattgttcaa aagctccgct tcacatacag gagcgacagt     3060

tttgagaatc cagtcctgca gcagcacttc cgcaacctgg aggccctagc tttggacatg     3120

atggagtcgg agcaagtggt agatctgaca ctacccaagg ttgaagccat aaagaaaaga     3180

ctgggttccc tggcagatga gtttaaagaa cttgtctatc ctccaggtta taatcccgag     3240

ggaaaagttg ccaagagaaa acaagatgat gaaggttcta cgagtaaaaa gcccaaggta     3300

gagttatcag aagaagagct gaaggcccat tttcgtaagg gcacactggg taagctcact     3360

gtacctacac tgaaggacat atgcaaggct catgggctta agagtgggcc gaagaagcag     3420

gaactgctag atgctcttat cagacacttg gagaagaact gaggatccac gcgtaaatga     3480

ttgcagatcc actagttcta gagctcgctg atcagcctcg actgtgcctt ctagttgcca     3540

gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac     3600

tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat     3660

tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca     3720

tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaaccagct ggggctcgag     3780

atccactagt tctagcctcg aggctagagc ggccgccacc gcggtggagc tccaattcgc     3840

cctatagtga gtcgtattac gcgcgctcac tggccgtcgt tttacaacgt cgtgactggg     3900

aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc     3960

gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg     4020

aatgggacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg     4080

tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc     4140

tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc     4200

gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta     4260

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     4320

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg     4380

atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa     4440

aatttaacgc gaattttaac aaaatattaa cgcttacaat ttaggtggca cttttcgggg     4500

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct     4560

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat     4620

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc     4680

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg     4740

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg     4800

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga     4860

cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta     4920

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc     4980

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc     5040

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg     5100

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc     5160

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca     5220

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct     5280

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat     5340

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg     5400

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat     5460

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact     5520

tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat     5580

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     5640

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     5700

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     5760

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     5820

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     5880

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     5940

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     6000

gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga     6060

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     6120

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     6180

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     6240

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     6300

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     6360

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     6420

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag     6480

gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca     6540

ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag     6600

cggataacaa tttcacacag gaaacagcta tgaccatgat tacgccaagc gcgcaattaa     6660

ccctcactaa agggaacaaa agct                                            6684


<210>  27
<211>  5961
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCAG-Ku80(427-732)-bpA

<400>  27
gggtaccggg ccccccctcg aggtcgacgg tatcgataag cttgatatcg aattcgagct       60

cggtacccgg gggcgcgccg gatctcgaca ttgattattg actagttatt aatagtaatc      120

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt      180

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta      240

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg actatttacg      300

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      360

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt      420

tcctacttgg cagtacatct acgtattagt catcgctatt accatgggtc gaggtgagcc      480

ccacgttctg cttcactctc cccatctccc ccccctcccc acccccaatt ttgtatttat      540

ttatttttta attattttgt gcagcgatgg gggcgggggg ggggggggcg cgcgccaggc      600

ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga gaggtgcggc ggcagccaat      660

cagagcggcg cgctccgaaa gtttcctttt atggcgaggc ggcggcggcg gcggccctat      720

aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc cttcgccccg tgccccgctc      780

cgcgccgcct cgcgccgccc gccccggctc tgactgaccg cgttactccc acaggtgagc      840

gggcgggacg gcccttctcc tccgggctgt aattagcgct tggtttaatg acggctcgtt      900

tcttttctgt ggctgcgtga aagccttaaa gggctccggg agggcccttt gtgcgggggg      960

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggcccgcg     1020

ctgcccggcg gctgtgagcg ctgcgggcgc ggcgcggggc tttgtgcgct ccgcgtgtgc     1080

gcgaggggag cgcggccggg ggcggtgccc cgcggtgcgg gggggctgcg aggggaacaa     1140

aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg ggtgtgggcg cggcggtcgg     1200

gctgtaaccc ccccctgcac ccccctcccc gagttgctga gcacggcccg gcttcgggtg     1260

cggggctccg tgcggggcgt ggcgcggggc tcgccgtgcc gggcgggggg tggcggcagg     1320

tgggggtgcc gggcggggcg gggccgcctc gggccgggga gggctcgggg gaggggcgcg     1380

gcggccccgg agcgccggcg gctgtcgagg cgcggcgagc cgcagccatt gccttttatg     1440

gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa atctggcgga gccgaaatct     1500

gggaggcgcc gccgcacccc ctctagcggg cgcgggcgaa gcggtgcggc gccggcagga     1560

aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt ctccatctcc     1620

agcctcgggg ctgccgcagg gggacggctg ccttcggggg ggacggggca gggcggggtt     1680

cggcttctgg cgtgtgaccg gcggctctag agcctctgct aaccatgttc atgccttctt     1740

ctttttccta cagatcctta attaataata cgactcacta taggggccgc caccatgccc     1800

aagaagaaga ggaaggtgat ggaagacttg cggcaataca tgttttcctc gctgaaaaac     1860

aataagaagt gcactcccac agaggcccag ctgagcgcta ttgatgatct gattgattcc     1920

atgagcttgg taaagaaaaa cgaggaagaa gacattgttg aagatttgtt tccaacctcc     1980

aaaattccaa atcctgaatt tcagcgattg taccagtgtc tgctgcatag agccttacat     2040

ctccaggagc ggctgccccc gattcagcag cacattttga atatgctgga tccccccact     2100

gagatgaaag caaaatgtga gagtccactc tctaaagtaa agaccctttt ccctctcaca     2160

gaagtcatca agaaaaagaa ccaagtgact gctcaggacg ttttccaaga caatcatgaa     2220

gaggggcccg ctgctaaaaa atataaaact gagaaagaag aagatcacat cagcatctcc     2280

agcctggcag aagggaacat caccaaggtt ggaagtgtga atcctgttga aaacttccgt     2340

ttcctagtaa gacagaagat tgccagcttt gaggaagcga gtctccagtt aataagtcac     2400

atcgaacaat ttttggatac caatgaaaca ctgtatttta tgaaaagtat ggactgcatc     2460

aaagctttcc gggaggaggc cattcagttt tcagaagaac agcgcttcaa cagcttcctg     2520

gaagcccttc gagagaaagt ggaaattaag caattaaatc atttctggga aattgttgtt     2580

caggatggag ttactctgat caccaaagac gaaggcccag gaagctctat cacagctgag     2640

gaagccacaa agtttctggc ccccaaagac aaagcaaaag aagatacaac gggacctgaa     2700

gaagctggtg atgtggatga tttactggac atgatatagc tgcagacgcg taaatgattg     2760

cagatccact agttctagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc     2820

atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt     2880

cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct     2940

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc     3000

tggggatgcg gtgggctcta tggcttctga ggcggaaaga accagctggg gctcgagatc     3060

cactagttct agcctcgagg ctagagcggc cgccaccgcg gtggagctcc aattcgccct     3120

atagtgagtc gtattacgcg cgctcactgg ccgtcgtttt acaacgtcgt gactgggaaa     3180

accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta     3240

atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat     3300

gggacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga     3360

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg     3420

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat     3480

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg     3540

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata     3600

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt     3660

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat     3720

ttaacgcgaa ttttaacaaa atattaacgc ttacaattta ggtggcactt ttcggggaaa     3780

tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat     3840

gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca     3900

acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca     3960

cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta     4020

catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt     4080

tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc     4140

cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc     4200

accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc     4260

cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa     4320

ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga     4380

accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat     4440

ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca     4500

attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc     4560

ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat     4620

tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag     4680

tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa     4740

gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca     4800

tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc     4860

ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc     4920

ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc     4980

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt     5040

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt     5100

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc     5160

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa     5220

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac     5280

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg     5340

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga     5400

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact     5460

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa     5520

cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc     5580

gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg     5640

ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat     5700

acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt     5760

tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta     5820

ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg     5880

ataacaattt cacacaggaa acagctatga ccatgattac gccaagcgcg caattaaccc     5940

tcactaaagg gaacaaaagc t                                               5961


<210>  28
<211>  89
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primerKu70-1

<400>  28
gatcttaatt aataatacga ctcactatag gggccgccac catgcccaag aagaagagga       60

aggtgatcca gtgtatccag agtgtgtac                                         89


<210>  29
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primerKu70-2

<400>  29
gatcacgcgt ggatcctcag ttcttctcca agtgtctg                               38


<210>  30
<211>  89
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primerKu80-1

<400>  30
gatcttaatt aataatacga ctcactatag gggccgccac catgcccaag aagaagagga       60

aggtgatgga agacttgcgg caatacatg                                         89


<210>  31
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primerKu80-2

<400>  31
gatcacgcgt ctgcagctat atcatgtcca gtaaatcatc                             40


<210>  32
<211>  6453
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCAG-Tal-IX-Fok

<400>  32
ggcgcgccgg attcgacatt gattattgac tagttattaa tagtaatcaa ttacggggtc       60

attagttcat agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc      120

tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt      180

aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca      240

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg      300

taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca      360

gtacatctac gtattagtca tcgctattac catggtcgag gtgagcccca cgttctgctt      420

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt      480

attttgtgca gcgatggggg cggggggggg gggggggcgc gcgccaggcg gggcggggcg      540

gggcgagggg cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc      600

gctccgaaag tttcctttta tggcgaggcg gcggcggcgg cggccctata aaaagcgaag      660

cgcgcggcgg gcgggagtcg ctgcgcgctg ccttcgcccc gtgccccgct ccgccgccgc      720

ctcgcgccgc ccgccccggc tctgactgac cgcgttactc ccacaggtga gcgggcggga      780

cggcccttct cctccgggct gtaattagcg cttggtttaa tgacggcttg tttcttttct      840

gtggctgcgt gaaagccttg aggggctccg ggagggccct ttgtgcgggg gggagcggct      900

cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc gcgctgcccg      960

gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt gtgcgcgagg     1020

ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg aacaaaggct     1080

gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg gtcgggctgc     1140

aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc     1200

tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg caggtggggg     1260

tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg cgcggcggcc     1320

cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat     1380

cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg aaatctggga     1440

ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc ggcaggaagg     1500

aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc cctctccagc     1560

ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg gcggggttcg     1620

gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat gccttcttct     1680

ttttcctaca gatccttaat taataatacg actcactata ggggccgcca ccatgggacc     1740

taagaaaaag aggaaggtgg cggccgctga ctacaaggat gacgacgata aaccaggtgg     1800

cggaggtagt ggcggaggtg gggtacccgc cagtccagca gcccaggtgg atctgagaac     1860

cctcggctac agccagcagc agcaggagaa gatcaaacca aaggtgcggt ccaccgtcgc     1920

tcagcaccat gaagcactgg tggggcacgg tttcacacac gcccatattg tggctctgtc     1980

tcagcatccc gctgcactcg ggactgtggc cgtcaaatat caggacatga tcgccgctct     2040

gcctgaggca acccacgaag ccattgtggg cgtcggaaag cagtggagcg gtgccagagc     2100

actcgaagca ctcctcaccg tcgccgggga actgcggggt ccaccactcc agtccggact     2160

ggacactgga cagctgctga agatcgctaa acgcggcgga gtgacagctg tggaagctgt     2220

gcacgcttgg aggaatgctc tgacaggagc cccactgaat cttatgagac gacgtctcac     2280

ggcctgaccc cacagcaggt cgtcgctatt gcttctaatg gcggagggcg gcctgctctg     2340

gagagcattg tggctcagct gtccaggccc gatcctgccc tggctagatc cgcactcact     2400

aacgatcatc tggtcgctct cgcttgcctc ggtggacggc ccgctctgga cgcagtcaaa     2460

aagggtctcc cccatgctcc cgcactgatc aagagaacca acaggagaat tcctgaggga     2520

tccgatcgtt taaaccagct cgtgaaaagc gaactcgaag aaaagaaaag tgaactgcgg     2580

cacaaactga aatacgtccc acatgaatac attgagctga tcgagattgc taggaactcc     2640

acccaggaca gaatcctcga gatgaaagtg atggaattct ttatgaaagt ctacgggtat     2700

cggggcaagc acctgggcgg atctcgcaaa ccagatgggg caatctacac tgtgggtagt     2760

cccatcgact atggcgtgat tgtcgatacc aaggcctaca gtgggggtta taatctgccc     2820

attggacagg ctgacgagat gcagcgatac gtggaggaaa accagacaag aaataagcat     2880

atcaacccca atgagtggtg gaaagtgtat cctagctccg tcactgaatt caagtttctc     2940

ttcgtgtcag gccactttaa gggaaactac aaagcacagc tgaccaggct caatcatatt     3000

acaaactgca atggcgccgt gctgagcgtc gaggaactgc tcatcggcgg agagatgatc     3060

aaggccggca cactcaccct ggaggaggtc cgccgaaaat tcaataacgg ggaaatcaac     3120

ttctgaacgc gtaaatgatt gcagatccac tagttctaga attccagctg agcgccggtc     3180

gctaccatta ccagttggtc tggtgtcaaa aataataata accgggcagg ggggatctgc     3240

atggatcttt gtgaaggaac cttacttctg tggtgtgaca taattggaca aactacctac     3300

agagatttaa agctctaagg taaatataaa atttttaagt gtataatgtg ttaaactact     3360

gattctaatt gtttgtgtat tttagattcc aacctatgga actgatgaat gggagcagtg     3420

gtggaatgcc agatccagac atgataagat acattgatga gtttggacaa accacaacta     3480

gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa     3540

ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt atgtttcagg     3600

ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa tgtggtatgg     3660

ctgattatga tctgcggccg ccactggccg tcgttttaca acgtcgtgac tgggaaaacc     3720

ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc tggcgtaata     3780

gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatgga     3840

acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg     3900

ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca     3960

cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta     4020

gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc     4080

catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg     4140

gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat     4200

aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta     4260

acgcgaattt taacaaaata ttaacgctta caatttaggt ggcacttttc ggggaaatgt     4320

gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag     4380

acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca     4440

tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc     4500

agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat     4560

cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc     4620

aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg     4680

gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc     4740

agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat     4800

aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga     4860

gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc     4920

ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc     4980

aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt     5040

aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc     5100

tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc     5160

agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca     5220

ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca     5280

ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa aacttcattt     5340

ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta     5400

acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg     5460

agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc     5520

ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag     5580

cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa     5640

gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc     5700

cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc     5760

gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta     5820

caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag     5880

aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct     5940

tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga     6000

gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc     6060

ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt     6120

atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg     6180

cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg     6240

caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg acaggtttcc     6300

cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca ctcattaggc     6360

accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg tgagcggata     6420

acaatttcac acaggaaaca gctatgacca tga                                  6453


<210>  33
<211>  7858
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCAG-RabChtTal-1

<400>  33
ggcgcgccgg attcgacatt gattattgac tagttattaa tagtaatcaa ttacggggtc       60

attagttcat agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc      120

tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt      180

aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca      240

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg      300

taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca      360

gtacatctac gtattagtca tcgctattac catggtcgag gtgagcccca cgttctgctt      420

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt      480

attttgtgca gcgatggggg cggggggggg gggggggcgc gcgccaggcg gggcggggcg      540

gggcgagggg cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc      600

gctccgaaag tttcctttta tggcgaggcg gcggcggcgg cggccctata aaaagcgaag      660

cgcgcggcgg gcgggagtcg ctgcgcgctg ccttcgcccc gtgccccgct ccgccgccgc      720

ctcgcgccgc ccgccccggc tctgactgac cgcgttactc ccacaggtga gcgggcggga      780

cggcccttct cctccgggct gtaattagcg cttggtttaa tgacggcttg tttcttttct      840

gtggctgcgt gaaagccttg aggggctccg ggagggccct ttgtgcgggg gggagcggct      900

cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc gcgctgcccg      960

gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt gtgcgcgagg     1020

ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg aacaaaggct     1080

gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg gtcgggctgc     1140

aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc     1200

tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg caggtggggg     1260

tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg cgcggcggcc     1320

cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat     1380

cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg aaatctggga     1440

ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc ggcaggaagg     1500

aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc cctctccagc     1560

ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg gcggggttcg     1620

gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat gccttcttct     1680

ttttcctaca gatccttaat taataatacg actcactata ggggccgcca ccatgggacc     1740

taagaaaaag aggaaggtgg cggccgctga ctacaaggat gacgacgata aaccaggtgg     1800

cggaggtagt ggcggaggtg gggtacccgc cagtccagca gcccaggtgg atctgagaac     1860

cctcggctac agccagcagc agcaggagaa gatcaaacca aaagttcgtt ccaccgtcgc     1920

tcagcaccat gaagcactgg tggggcacgg tttcacacac gcccatattg tggctctgtc     1980

tcaacatccc gctgcactcg ggactgtggc cgtcaaatat caggacatga tcgccgctct     2040

gcctgaggca acccacgaag ccattgttgg cgtcggaaag cagtggagcg gtgccagagc     2100

actcgaagca ctcctcaccg tcgccgggga actgcggggt ccaccactcc agtccggact     2160

ggacactgga cagctgctga agatcgctaa acgcggcgga gtgacagctg tggaagctgt     2220

gcacgcttgg aggaatgctc tgacaggagc cccactgaat cttacacccg aacaggtggt     2280

ggccatcgct agtaacattg ggggcaaaca ggctctggaa acagtacagc ggctgttacc     2340

tgtgctgtgc caggctcatg gcctcacacc tcagcaggtc gtcgcaatcg cctccaatgg     2400

cggagggaag caggccctgg aaacggtgca gagactgtta ccagtgctgt gccaggccca     2460

tggcctaaca ccccagcagg tggtggccat cgccagccac gacggcggca agcaggccct     2520

ggaaaccgtg cagaggctgc tgcctgtgct gtgccaggct catggcctga cacctgagca     2580

ggtcgtcgcc atcgccagca acatcggcgg caagcaggcc ctggaaaccg tgcagaggct     2640

gctgccagtg ctgtgccagg cccatggctt aacacccgaa caggtggtgg ccatcgcttc     2700

taatattggg ggcaagcagg ccctggaaac agtccagaga ctgttgcctg tgctgtgcca     2760

ggctcatggc ttgacacctc agcaggtcgt cgctatcgcc tctaataatg ggggcaagca     2820

ggctctggag acagtacagc gcctgttacc agtgctgtgc caggcccacg ggctcacacc     2880

ccagcaggtg gtggcaatcg cttcccatga cggagggaaa caggctctgg aaacggtcca     2940

gaggctgctc cctgtgctgt gccaggctca cggtctaaca ccccagcagg tggtggccat     3000

tgctagcaac aatgggggca agcaggctct ggagacagtg cagcgcctgc tgcctgtgct     3060

gtgccaggct catggcctca cacctcagca ggtcgtcgcc atcgccagcc acgacggcgg     3120

caagcaggcc ctggaaaccg tgcagaggct gctgccagtg ctgtgccagg cccatggcct     3180

aacaccccag caggtggtgg caatcgcctc caatggcgga gggaagcagg ccctggaaac     3240

ggtgcagaga ctgttacctg tgctgtgcca ggctcatggc ctgacacctg agcaggtcgt     3300

cgctatcgct agcaatatcg gagggaagca ggctctggaa actgtccagc gcctgctccc     3360

agtgctgtgc caggcccatg gcttaacacc ccagcaggtg gtggcaattg ctagcaatgg     3420

cggagggaag caggccctgg agactgtcca gagactgcta cctgtgctgt gccaggctca     3480

tggcttgaca cctcagcagg tcgtcgctat cgcctctaat aatgggggca agcaggctct     3540

ggagacagta cagcgcctgt taccagtgct gtgccaggcc cacgggctca caccccagca     3600

ggtggtggcc atcgccagca acggcggcgg caagcaggcc ctggaaaccg tgcagaggct     3660

gctgcctgtg ctgtgccagg ctcacggcct gaccccacag caggtcgtcg ctattgcttc     3720

taatggcgga gggcggcctg ctctggagag cattgtggct cagctgtcca ggcccgatcc     3780

tgccctggct agatccgcac tcactaacga tcatctggtc gctctcgctt gcctcggtgg     3840

acggcccgct ctggacgcag tcaaaaaggg tctcccccat gctcccgcac tgatcaagag     3900

aaccaacagg agaattcctg agggatccga tcgtttaaac cagctcgtga aaagcgaact     3960

cgaagaaaag aaaagtgaac tgcggcacaa actgaaatac gtcccacatg aatacattga     4020

gctgatcgag attgctagga actccaccca ggacagaatc ctcgagatga aagtgatgga     4080

attctttatg aaagtctacg ggtatcgggg caagcacctg ggcggatctc gcaaaccaga     4140

tggggcaatc tacactgtgg gtagtcccat cgactatggc gtgattgtcg ataccaaggc     4200

ctacagtggg ggttataatc tgcccattgg acaggctgac gagatgcagc gatacgtgga     4260

ggaaaaccag acaagaaata agcatatcaa ccccaatgag tggtggaaag tgtatcctag     4320

ctccgtcact gaattcaagt ttctcttcgt gtctggccac tttaagggaa actacaaagc     4380

acagctgacc aggctcaatc atattacaaa ctgcaatggc gccgtgctga gcgtcgagga     4440

actgctcatc ggcggagaga tgatcaaggc cggcacactc accctggagg aggtccgccg     4500

aaaattcaat aacggggaaa tcaacttctg aacgcgtaaa tgattgcaga tccactagtt     4560

ctagaattcc agctgagcgc cggtcgctac cattaccagt tggtctggtg tcaaaaataa     4620

taataaccgg gcagggggga tctgcatgga tctttgtgaa ggaaccttac ttctgtggtg     4680

tgacataatt ggacaaacta cctacagaga tttaaagctc taaggtaaat ataaaatttt     4740

taagtgtata atgtgttaaa ctactgattc taattgtttg tgtattttag attccaacct     4800

atggaactga tgaatgggag cagtggtgga atgccagatc cagacatgat aagatacatt     4860

gatgagtttg gacaaaccac aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt     4920

tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac     4980

aattgcattc attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag     5040

taaaacctct acaaatgtgg tatggctgat tatgatctgc ggccgccact ggccgtcgtt     5100

ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat     5160

ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag     5220

ttgcgcagcc tgaatggcga atggaacgcg ccctgtagcg gcgcattaag cgcggcgggt     5280

gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc     5340

gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg     5400

gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat     5460

tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg     5520

ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct     5580

atctcggtct attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa     5640

aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac gcttacaatt     5700

taggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac     5760

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa     5820

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat     5880

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc     5940

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga     6000

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg     6060

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc     6120

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag     6180

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc     6240

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg     6300

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg     6360

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac     6420

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac     6480

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg     6540

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg     6600

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg     6660

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     6720

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     6780

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     6840

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     6900

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     6960

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     7020

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     7080

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     7140

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     7200

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     7260

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     7320

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     7380

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     7440

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     7500

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     7560

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     7620

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     7680

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     7740

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     7800

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatga       7858


<210>  34
<211>  7858
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCAG-RabChtTal-2

<400>  34
ggcgcgccgg attcgacatt gattattgac tagttattaa tagtaatcaa ttacggggtc       60

attagttcat agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc      120

tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt      180

aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca      240

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg      300

taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca      360

gtacatctac gtattagtca tcgctattac catggtcgag gtgagcccca cgttctgctt      420

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt      480

attttgtgca gcgatggggg cggggggggg gggggggcgc gcgccaggcg gggcggggcg      540

gggcgagggg cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc      600

gctccgaaag tttcctttta tggcgaggcg gcggcggcgg cggccctata aaaagcgaag      660

cgcgcggcgg gcgggagtcg ctgcgcgctg ccttcgcccc gtgccccgct ccgccgccgc      720

ctcgcgccgc ccgccccggc tctgactgac cgcgttactc ccacaggtga gcgggcggga      780

cggcccttct cctccgggct gtaattagcg cttggtttaa tgacggcttg tttcttttct      840

gtggctgcgt gaaagccttg aggggctccg ggagggccct ttgtgcgggg gggagcggct      900

cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc gcgctgcccg      960

gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt gtgcgcgagg     1020

ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg aacaaaggct     1080

gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg gtcgggctgc     1140

aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc     1200

tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg caggtggggg     1260

tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg cgcggcggcc     1320

cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat     1380

cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg aaatctggga     1440

ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc ggcaggaagg     1500

aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc cctctccagc     1560

ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg gcggggttcg     1620

gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat gccttcttct     1680

ttttcctaca gatccttaat taataatacg actcactata ggggccgcca ccatgggacc     1740

taagaaaaag aggaaggtgg cggccgctga ctacaaggat gacgacgata aaccaggtgg     1800

cggaggtagt ggcggaggtg gggtacccgc cagtccagca gcccaggtgg atctgagaac     1860

cctcggctac agccagcagc agcaggagaa gatcaaacca aaagttcgtt ccaccgtcgc     1920

tcagcaccat gaagcactgg tggggcacgg tttcacacac gcccatattg tggctctgtc     1980

tcaacatccc gctgcactcg ggactgtggc cgtcaaatat caggacatga tcgccgctct     2040

gcctgaggca acccacgaag ccattgttgg cgtcggaaag cagtggagcg gtgccagagc     2100

actcgaagca ctcctcaccg tcgccgggga actgcggggt ccaccactcc agtccggact     2160

ggacactgga cagctgctga agatcgctaa acgcggcgga gtgacagctg tggaagctgt     2220

gcacgcttgg aggaatgctc tgacaggagc cccactgaat cttacacccc agcaggtggt     2280

ggccattgct agcaacaatg ggggcaagca ggctctggag acagtgcagc gcctgctgcc     2340

tgtgctgtgc caggctcatg gcctcacacc tcagcaggtc gtcgccattg cttctaacaa     2400

tggagggaag caggctctgg agactgtgca gagactgctg ccagtgctgt gccaggccca     2460

tggcctaaca ccccagcagg tggtggccat cgccagccac gacggcggca agcaggccct     2520

ggaaaccgtg cagaggctgc tgcctgtgct gtgccaggct catggcctga cacctcagca     2580

ggtcgtcgcc atcgccagcc acgacggcgg caagcaggcc ctggaaaccg tgcagaggct     2640

gctgccagtg ctgtgccagg cccatggctt aacaccccag caggtggtgg ccatcgctag     2700

tcatgacggg ggcaaacagg ctctggaaac agtacagcgg ctgttacctg tgctgtgcca     2760

ggctcatggc ttgacacctc agcaggtcgt cgctatcgcc tctaataatg ggggcaagca     2820

ggctctggag acagtacagc gcctgttacc agtgctgtgc caggcccacg ggctcacacc     2880

ccagcaggtg gtggcaattg cttccaataa cggcggaaaa caggctctgg aaaccgtcca     2940

gaggctgctg cctgtgctgt gccaggctca cggtctaaca ccccagcagg tggtggccat     3000

cgcttccaac ggagggggca aacaggctct ggaaacagtg cagaggctgc tgcctgtgct     3060

gtgccaggct catggcctca cacctgagca ggtcgtcgcc atcgccagca acatcggcgg     3120

caagcaggcc ctggaaaccg tgcagaggct gctgccagtg ctgtgccagg cccatggcct     3180

aacaccccag caggtggtgg caattgcttc caataacggc ggaaaacagg ctctggaaac     3240

cgtccagagg ctgctgcctg tgctgtgcca ggctcatggc ctgacacctc agcaggtcgt     3300

cgcaatcgcc tccaatggcg gagggaagca ggccctggaa acggtgcaga gactgttacc     3360

agtgctgtgc caggcccatg gcttaacacc ccagcaggtg gtggcaatcg cctctaataa     3420

cggagggaag caggccctgg aaaccgtgca gagactgtta cctgtgctgt gccaggctca     3480

tggcttgaca cctcagcagg tcgtcgctat cgctagtcat gatggcggaa aacaggctct     3540

ggaaactgtg cagcggctgc tcccagtgct gtgccaggcc cacgggctca caccccagca     3600

ggtggtggca atcgcctcta ataacggagg gaagcaggcc ctggaaaccg tgcagagact     3660

gttacctgtg ctgtgccagg ctcacggcct gaccccacag caggtcgtcg ctattgcttc     3720

taatggcgga gggcggcctg ctctggagag cattgtggct cagctgtcca ggcccgatcc     3780

tgccctggct agatccgcac tcactaacga tcatctggtc gctctcgctt gcctcggtgg     3840

acggcccgct ctggacgcag tcaaaaaggg tctcccccat gctcccgcac tgatcaagag     3900

aaccaacagg agaattcctg agggatccga tcgtttaaac cagctcgtga aaagcgaact     3960

cgaagaaaag aaaagtgaac tgcggcacaa actgaaatac gtcccacatg aatacattga     4020

gctgatcgag attgctagga actccaccca ggacagaatc ctcgagatga aagtgatgga     4080

attctttatg aaagtctacg ggtatcgggg caagcacctg ggcggatctc gcaaaccaga     4140

tggggcaatc tacactgtgg gtagtcccat cgactatggc gtgattgtcg ataccaaggc     4200

ctacagtggg ggttataatc tgcccattgg acaggctgac gagatgcagc gatacgtgga     4260

ggaaaaccag acaagaaata agcatatcaa ccccaatgag tggtggaaag tgtatcctag     4320

ctccgtcact gaattcaagt ttctcttcgt gtctggccac tttaagggaa actacaaagc     4380

acagctgacc aggctcaatc atattacaaa ctgcaatggc gccgtgctga gcgtcgagga     4440

actgctcatc ggcggagaga tgatcaaggc cggcacactc accctggagg aggtccgccg     4500

aaaattcaat aacggggaaa tcaacttctg aacgcgtaaa tgattgcaga tccactagtt     4560

ctagaattcc agctgagcgc cggtcgctac cattaccagt tggtctggtg tcaaaaataa     4620

taataaccgg gcagggggga tctgcatgga tctttgtgaa ggaaccttac ttctgtggtg     4680

tgacataatt ggacaaacta cctacagaga tttaaagctc taaggtaaat ataaaatttt     4740

taagtgtata atgtgttaaa ctactgattc taattgtttg tgtattttag attccaacct     4800

atggaactga tgaatgggag cagtggtgga atgccagatc cagacatgat aagatacatt     4860

gatgagtttg gacaaaccac aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt     4920

tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac     4980

aattgcattc attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag     5040

taaaacctct acaaatgtgg tatggctgat tatgatctgc ggccgccact ggccgtcgtt     5100

ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat     5160

ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag     5220

ttgcgcagcc tgaatggcga atggaacgcg ccctgtagcg gcgcattaag cgcggcgggt     5280

gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc     5340

gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg     5400

gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat     5460

tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg     5520

ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct     5580

atctcggtct attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa     5640

aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac gcttacaatt     5700

taggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac     5760

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa     5820

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat     5880

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc     5940

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga     6000

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg     6060

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc     6120

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag     6180

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc     6240

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg     6300

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg     6360

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac     6420

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac     6480

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg     6540

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg     6600

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg     6660

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     6720

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     6780

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     6840

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     6900

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     6960

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     7020

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     7080

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     7140

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     7200

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     7260

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     7320

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     7380

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     7440

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     7500

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     7560

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     7620

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     7680

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     7740

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     7800

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatga       7858


<210>  35
<211>  932
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RabChtTal-1

<400>  35

Met Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Asp Tyr Lys Asp 
1               5                   10                  15      


Asp Asp Asp Lys Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Val Pro 
            20                  25                  30          


Ala Ser Pro Ala Ala Gln Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln 
        35                  40                  45              


Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln 
    50                  55                  60                  


His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His Ile Val 
65                  70                  75                  80  


Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr 
                85                  90                  95      


Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val 
            100                 105                 110         


Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu 
        115                 120                 125             


Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Ser Gly Leu Asp 
    130                 135                 140                 


Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 
145                 150                 155                 160 


Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 
                165                 170                 175     


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
            180                 185                 190         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        195                 200                 205             


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
    210                 215                 220                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
225                 230                 235                 240 


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser His 
                245                 250                 255     


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
            260                 265                 270         


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
        275                 280                 285             


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
    290                 295                 300                 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
        355                 360                 365             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
    370                 375                 380                 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
385                 390                 395                 400 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                405                 410                 415     


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
            420                 425                 430         


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        435                 440                 445             


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
    450                 455                 460                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
465                 470                 475                 480 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
                485                 490                 495     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            500                 505                 510         


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
        515                 520                 525             


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    530                 535                 540                 


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
545                 550                 555                 560 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
                565                 570                 575     


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
            580                 585                 590         


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
        595                 600                 605             


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
    610                 615                 620                 


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
625                 630                 635                 640 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
                645                 650                 655     


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu 
            660                 665                 670         


Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Arg Ser 
        675                 680                 685             


Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg 
    690                 695                 700                 


Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Ala Leu 
705                 710                 715                 720 


Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu Gly Ser Asp Arg Leu Asn 
                725                 730                 735     


Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
            740                 745                 750         


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
        755                 760                 765             


Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
    770                 775                 780                 


Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 
785                 790                 795                 800 


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
                805                 810                 815     


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
            820                 825                 830         


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg 
        835                 840                 845             


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
    850                 855                 860                 


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
865                 870                 875                 880 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
                885                 890                 895     


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
            900                 905                 910         


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
        915                 920                 925             


Glu Ile Asn Phe 
    930         


<210>  36
<211>  932
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RabChtTal-2

<400>  36

Met Gly Pro Lys Lys Lys Arg Lys Val Ala Ala Ala Asp Tyr Lys Asp 
1               5                   10                  15      


Asp Asp Asp Lys Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Val Pro 
            20                  25                  30          


Ala Ser Pro Ala Ala Gln Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln 
        35                  40                  45              


Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln 
    50                  55                  60                  


His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His Ile Val 
65                  70                  75                  80  


Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr 
                85                  90                  95      


Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val 
            100                 105                 110         


Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu 
        115                 120                 125             


Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Ser Gly Leu Asp 
    130                 135                 140                 


Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 
145                 150                 155                 160 


Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 
                165                 170                 175     


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
            180                 185                 190         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        195                 200                 205             


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
    210                 215                 220                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
225                 230                 235                 240 


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser His 
                245                 250                 255     


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
            260                 265                 270         


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
        275                 280                 285             


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
    290                 295                 300                 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
        355                 360                 365             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
    370                 375                 380                 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
385                 390                 395                 400 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                405                 410                 415     


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
            420                 425                 430         


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        435                 440                 445             


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
    450                 455                 460                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
465                 470                 475                 480 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
                485                 490                 495     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            500                 505                 510         


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
        515                 520                 525             


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    530                 535                 540                 


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
545                 550                 555                 560 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
                565                 570                 575     


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
            580                 585                 590         


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
        595                 600                 605             


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
    610                 615                 620                 


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
625                 630                 635                 640 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
                645                 650                 655     


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu 
            660                 665                 670         


Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Arg Ser 
        675                 680                 685             


Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg 
    690                 695                 700                 


Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Ala Leu 
705                 710                 715                 720 


Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu Gly Ser Asp Arg Leu Asn 
                725                 730                 735     


Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
            740                 745                 750         


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
        755                 760                 765             


Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
    770                 775                 780                 


Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 
785                 790                 795                 800 


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
                805                 810                 815     


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
            820                 825                 830         


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg 
        835                 840                 845             


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
    850                 855                 860                 


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
865                 870                 875                 880 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
                885                 890                 895     


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
            900                 905                 910         


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
        915                 920                 925             


Glu Ile Asn Phe 
    930         


<210>  37
<211>  9989
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pCMV-Rab-Reporter(hygro)

<400>  37
gaattcgagc ttgcatgcct gcaggtcgtt acataactta cggtaaatgg cccgcctggc       60

tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg      120

ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg      180

gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa      240

tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac      300

atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg      360

cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg      420

agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca      480

ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta      540

gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac      600

cgggaccgat ccagcctccg gactctagag gatccggtac tcgaggacac tgcagagacc      660

tacttcacta acaaccggta tggtcgccag tagcttggca ctggccgtcg ttttacaacg      720

tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc cttgcagcac atcccccttt      780

cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag      840

cctgaatggc gaatggcgct ttgcctggtt tccggcacca gaagcggtgc cggaaagctg      900

gctggagtgc gatcttcctg aggccgatac tgtcgtcgtc ccctcaaact ggcagatgca      960

cggttacgat gcgcccatct acaccaacgt gacctatccc attacggtca atccgccgtt     1020

tgttcccacg gagaatccga cgggttgtta ctcgctcaca tttaatgttg atgaaagctg     1080

gctataaaac cggtacagtt cggccaccat ggtcgtatca agcgctatgt gcaccaaaac     1140

ttctcctcgc actaccgggc caccattggt cgagtagctt ggcactggcc gtcgttttac     1200

aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc     1260

ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc     1320

gcagcctgaa tggcgaatgg cgctttgcct ggtttccggc accagaagcg gtgccggaaa     1380

gctggctgga gtgcgatctt cctgaggccg atactgtcgt cgtcccctca aactggcaga     1440

tgcacggtta cgatgcgccc atctacacca acgtgaccta tcccattacg gtcaatccgc     1500

cgtttgttcc cacggagaat ccgacgggtt gttactcgct cacatttaat gttgatgaaa     1560

gctggctaca ggaaggccag acgcgaatta tttttgatgg cgttaactcg gcgtttcatc     1620

tgtggtgcaa cgggcgctgg gtcggttacg gccaggacag tcgtttgccg tctgaatttg     1680

acctgagcgc atttttacgc gccggagaaa accgcctcgc ggtgatggtg ctgcgctgga     1740

gtgacggcag ttatctggaa gatcaggata tgtggcggat gagcggcatt ttccgtgacg     1800

tctcgttgct gcataaaccg actacacaaa tcagcgattt ccatgttgcc actcgcttta     1860

atgatgattt cagccgcgct gtactggagg ctgaagttca gatgtgcggc gagttgcgtg     1920

actacctacg ggtaacagtt tctttatggc agggtgaaac gcaggtcgcc agcggcaccg     1980

cgcctttcgg cggtgaaatt atcgatgagc gtggtggtta tgccgatcgc gtcacactac     2040

gtctgaacgt cgaaaacccg aaactgtgga gcgccgaaat cccgaatctc tatcgtgcgg     2100

tggttgaact gcacaccgcc gacggcacgc tgattgaagc agaagcctgc gatgtcggtt     2160

tccgcgaggt gcggattgaa aatggtctgc tgctgctgaa cggcaagccg ttgctgattc     2220

gaggcgttaa ccgtcacgag catcatcctc tgcatggtca ggtcatggat gagcagacga     2280

tggtgcagga tatcctgctg atgaagcaga acaactttaa cgccgtgcgc tgttcgcatt     2340

atccgaacca tccgctgtgg tacacgctgt gcgaccgcta cggcctgtat gtggtggatg     2400

aagccaatat tgaaacccac ggcatggtgc caatgaatcg tctgaccgat gatccgcgct     2460

ggctaccggc gatgagcgaa cgcgtaacgc gaatggtgca gcgcgatcgt aatcacccga     2520

gtgtgatcat ctggtcgctg gggaatgaat caggccacgg cgctaatcac gacgcgctgt     2580

atcgctggat caaatctgtc gatccttccc gcccggtgca gtatgaaggc ggcggagccg     2640

acaccacggc caccgatatt atttgcccga tgtacgcgcg cgtggatgaa gaccagccct     2700

tcccggctgt gccgaaatgg tccatcaaaa aatggctttc gctacctgga gagacgcgcc     2760

cgctgatcct ttgcgaatac gcccacgcga tgggtaacag tcttggcggt ttcgctaaat     2820

actggcaggc gtttcgtcag tatccccgtt tacagggcgg cttcgtctgg gactgggtgg     2880

atcagtcgct gattaaatat gatgaaaacg gcaacccgtg gtcggcttac ggcggtgatt     2940

ttggcgatac gccgaacgat cgccagttct gtatgaacgg tctggtcttt gccgaccgca     3000

cgccgcatcc agcgctgacg gaagcaaaac accagcagca gtttttccag ttccgtttat     3060

ccgggcaaac catcgaagtg accagcgaat acctgttccg tcatagcgat aacgagctcc     3120

tgcactggat ggtggcgctg gatggtaagc cgctggcaag cggtgaagtg cctctggatg     3180

tcgctccaca aggtaaacag ttgattgaac tgcctgaact accgcagccg gagagcgccg     3240

ggcaactctg gctcacagta cgcgtagtgc aaccgaacgc gaccgcatgg tcagaagccg     3300

ggcacatcag cgcctggcag cagtggcgtc tggcggaaaa cctcagtgtg acgctccccg     3360

ccgcgtccca cgccatcccg catctgacca ccagcgaaat ggatttttgc atcgagctgg     3420

gtaataagcg ttggcaattt aaccgccagt caggctttct ttcacagatg tggattggcg     3480

ataaaaaaca actgctgacg ccgctgcgcg atcagttcac ccgtgcaccg ctggataacg     3540

acattggcgt aagtgaagcg acccgcattg accctaacgc ctgggtcgaa cgctggaagg     3600

cggcgggcca ttaccaggcc gaagcagcgt tgttgcagtg cacggcagat acacttgctg     3660

atgcggtgct gattacgacc gctcacgcgt ggcagcatca ggggaaaacc ttatttatca     3720

gccggaaaac ctaccggatt gatggtagtg gtcaaatggc gattaccgtt gatgttgaag     3780

tggcgagcga tacaccgcat ccggcgcgga ttggcctgaa ctgccagctg gcgcaggtag     3840

cagagcgggt aaactggctc ggattagggc cgcaagaaaa ctatcccgac cgccttactg     3900

ccgcctgttt tgaccgctgg gatctgccat tgtcagacat gtataccccg tacgtcttcc     3960

cgagcgaaaa cggtctgcgc tgcgggacgc gcgaattgaa ttatggccca caccagtggc     4020

gcggcgactt ccagttcaac atcagccgct acagtcaaca gcaactgatg gaaaccagcc     4080

atcgccatct gctgcacgcg gaagaaggca catggctgaa tatcgacggt ttccatatgg     4140

ggattggtgg cgacgactcc tggagcccgt cagtatcggc ggaattccag ctgagcgccg     4200

gtcgctacca ttaccagttg gtctggtgtc aggggatccc ccgggctgca gccaatatgg     4260

gatcggccat tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc     4320

tattcggcta tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgttccggc     4380

tgtcagcgca ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg     4440

aactgcagga cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag     4500

ctgtgctcga cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg     4560

ggcaggatct cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg     4620

caatgcggcg gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac     4680

atcgcatcga gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg     4740

acgaagagca tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgcgcatgc     4800

ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat atcatggtgg     4860

aaaatggccg cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc     4920

aggacatagc gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc     4980

gcttcctcgt gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc     5040

ttcttgacga gttcttctga ggggatcaat tctctagagc tcgctgatca gcctcgactg     5100

tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg     5160

aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga     5220

gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg     5280

aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag acggaaagaa     5340

ccagctgggg ctcgatcctc tagagtcgac gtttgatctg atatcatcga tgaattctac     5400

cgggtagggg aggcgctttt cccaaggcag tctggagcat gcgctttagc agccccgctg     5460

ggcacttggc gctacacaag tggcctctgg cctcgcacac attccacatc caccggtagg     5520

cgccaaccgg ctccgttctt tggtggcccc ttcgcgccac cttctactcc tcccctagtc     5580

aggaagttcc cccccgcccc gcagctcgcg tcgtgcagga cgtgacaaat ggaagtagca     5640

cgtctcacta gtctcgtgca gatggacagc accgctgagc aatggaagcg ggtaggcctt     5700

tggggcagcg gccaatagca gctttgctcc ttcgctttct gggctcagag gctgggaagg     5760

ggtgggtccg ggggcgggct caggggcggg ctcaggggcg gggcgggcgc ccgaaggtcc     5820

tccggaggcc cggcattctg cacgcttcaa aagcgcacgt ctgccgcgct gttctcctct     5880

tcctcatctc cgggcctttc gaccgatcca gccgccacca tgaaaaagcc tgaactcacc     5940

gcgacgtctg tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag     6000

ctctcggagg gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc     6060

ctgcgggtaa atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt     6120

gcatcggccg cgctcccgat tccggaagtg cttgacattg gggaattcag cgagagcctg     6180

acctattgca tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa     6240

ctgcccgctg ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt     6300

agccagacga gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg     6360

cgtgatttca tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac     6420

gacaccgtca gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac     6480

tgccccgaag tccggcacct cgtgcacgcg gatttcggct ccaacaatgt cctgacggac     6540

aatggccgca taacagcggt cattgactgg agcgaggcga tgttcgggga ttcccaatac     6600

gaggtcgcca acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc     6660

tacttcgagc ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc gtatatgctc     6720

cgcattggtc ttgaccaact ctatcagagc ttggttgacg gcaatttcga tgatgcagct     6780

tgggcgcagg gtcgatgcga cgcaatcgtc cgatccggag ccgggactgt cgggcgtaca     6840

caaatcgccc gcagaagcgc ggccgtctgg accgatggct gtgtagaagt actcgccgat     6900

agtggaaacc gacgccccag cactcgtccg agggcaaagg aatagtcgag aaattgatga     6960

tctattaaac aataaagatg tccactaaaa tggaagtttt tcctgtcata ctttgttaag     7020

aagggtgaga acagagtacc tacattttga atggaaggat tggagctacg ggggtggggg     7080

tggggtggga ttagataaat gcctgctctt tactgaaggc tctttactat tgctttatga     7140

taatgtttca tagttggata tcataattta aacaagcaaa accaaattaa gggccagctc     7200

attcctccca ctcatgatct atagatcaaa catgcatgaa gttcctattc cgaagttcct     7260

attctctaga aagtatagga acttcataaa acctgcaggc atgcaagcga tcgcggccgg     7320

ccaaggcccg cggggccact agttctagag cggccagctt ggcgtaatca tggtcatagc     7380

tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca     7440

taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct     7500

cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac     7560

gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc     7620

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt     7680

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg     7740

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg     7800

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat     7860

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta     7920

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct     7980

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc     8040

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa     8100

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg     8160

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag     8220

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt     8280

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta     8340

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc     8400

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca     8460

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa     8520

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat     8580

ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct     8640

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt     8700

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat     8760

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta     8820

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg     8880

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt     8940

tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg     9000

cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg     9060

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc     9120

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa     9180

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac     9240

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt     9300

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg     9360

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa     9420

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata     9480

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc taagaaacca     9540

ttattatcat gacattaacc tataaaaata ggcgtatcac gaggcccttt cgtctcgcgc     9600

gtttcggtga tgacggtgaa aacctctgac acatgcagct cccggagacg gtcacagctt     9660

gtctgtaagc ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg     9720

ggtgtcgggg ctggcttaac tatgcggcat cagagcagat tgtactgaga gtgcaccata     9780

tgcggtgtga aataccgcac agatgcgtaa ggagaaaata ccgcatcagg cgccattcgc     9840

cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc     9900

agctggcgaa agggggatgt gctgcaaggc gattaagttg ggtaacgcca gggttttccc     9960

agtcacgacg ttgtaaaacg acggccagt                                       9989


<210>  38
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tal effector motif (repeat) #11 of the Xanthomonas Hax3 protein

<400>  38

Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly 
        


<210>  39
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tal effector motif (repeat) #5 derived from the Xanthomonas Hax3 
       protein

<400>  39

Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly 
        


<210>  40
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tal effector motif (repeat) #4 from the Xanthomonas Hax4 protein

<400>  40

Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly 
        


<210>  41
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tal effector motif (repeat) #4 from the Hax4 protein with 
       replacement of the amino acids 12 into N and 13 into N

<400>  41

Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly 
        


