                         SEQUENCE LISTING

<110>  Keefe, Dennis
       Concino, Michael
       Heartlein, Michael
       Josiah, Serene
       Strack-Logue, Bettina
 
<120>  MITOCHONDRIAL TARGETING AND THERAPEUTIC USE THEREOF

<130>  2006685-0147

<150>  US 61/498,430
<151>  2011-06-17

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
1               5                   10                  15      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            20                  25                  30          


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        35                  40                  45              


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    50                  55                  60                  


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
65                  70                  75                  80  


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                85                  90                  95      


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            100                 105                 110         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        115                 120                 125             


Asp Ala 
    130 


<210>  2
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln 
            20  


<210>  3
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


<210>  4
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala 
    210 


<210>  5
<211>  12
<212>  PRT
<213>  Human immunodeficiency virus

<400>  5

Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10          


<210>  6
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal FXN-TAT fusion protein

<400>  6

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
    210                 215                 220         


<210>  7
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal FXN-TAT fusion protein

<400>  7

Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Met Trp Thr Leu 
1               5                   10                  15      


Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro Ser Pro Ala Gln 
            20                  25                  30          


Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu Leu Ala Pro Leu 
        35                  40                  45              


Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala Thr Cys Thr Pro 
    50                  55                  60                  


Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln Ile Trp Asn Val 
65                  70                  75                  80  


Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys Ser Gly Thr Leu 
                85                  90                  95      


Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu Arg Leu Ala Glu 
            100                 105                 110         


Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp Leu Ala Asp Lys 
        115                 120                 125             


Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly Ser Gly Val Leu 
    130                 135                 140                 


Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val Ile Asn Lys Gln 
145                 150                 155                 160 


Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser Ser Gly Pro Lys 
                165                 170                 175     


Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser His Asp Gly Val 
            180                 185                 190         


Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys Ala Leu Lys Thr 
        195                 200                 205             


Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys Asp Ala 
    210                 215                 220         


