                         SEQUENCE LISTING

<110>  University of Florida Research Foundation, Inc.
       Johnson, Howard
       Ahmed, Chulbul
 
<120>  TYPE I INTERFERON MIMETICS AS THERAPEUTICS FOR CANCER, VIRAL INFECTIONS, AND MULTIPLE SCLEROSIS

<130>  UF.993XC1PCT

<150>  61/499,495
<151>  2011-06-21

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  1

Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu His Glu Leu Ile 
1               5                   10                  15      


Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser Ser Ala Ala Trp 
            20                  25                  30          


Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu Tyr Gln Gln Leu 
        35                  40                  45              


Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg Val Gly Glu Thr 
    50                  55                  60                  


Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys Lys Tyr Phe Arg 
65                  70                  75                  80  


Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp 
                85                  90                  95      


Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser Leu Ser Thr Asn 
            100                 105                 110         


Leu Gln Glu Arg Leu Arg Arg Lys Glu 
        115                 120     


<210>  2
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  2

Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val Tyr His Gln 
1               5                   10                  15      


Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu Lys Glu Asp 
            20                  25                  30          


Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys Arg Tyr Tyr 
        35                  40                  45              


Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser His Cys Ala 
    50                  55                  60                  


Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr Phe Ile Asn 
65                  70                  75                  80  


Arg Leu Thr Gly Tyr Leu Arg Asn 
                85              


<210>  3
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Arg Arg Arg Arg Arg Arg Arg Arg Asn Gln Phe Gln Lys Ala Pro 
1               5                   10                  15      


Ala Ile Ser Val Leu His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe 
            20                  25                  30          


Thr Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys 
        35                  40                  45              


Phe Cys Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val 
    50                  55                  60                  


Met Gln Glu Glu Arg Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser 
65                  70                  75                  80  


Ile Leu Ala Val Lys Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr 
                85                  90                  95      


Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile 
            100                 105                 110         


Met Arg Ser Leu Ser Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg 
        115                 120                 125             


Lys Glu 
    130 


<210>  4
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Arg Arg Arg Arg Arg Arg Arg Arg Trp Asn Glu Thr Ile Val Glu 
1               5                   10                  15      


Asn Leu Leu Ala Asn Val Tyr His Gln Ile Asn His Leu Lys Thr Val 
            20                  25                  30          


Leu Glu Glu Lys Leu Glu Lys Glu Asp Phe Thr Arg Gly Lys Leu Met 
        35                  40                  45              


Ser Ser Leu His Leu Lys Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu 
    50                  55                  60                  


Lys Ala Lys Glu Tyr Ser His Cys Ala Trp Thr Ile Val Arg Val Glu 
65                  70                  75                  80  


Ile Leu Arg Asn Phe Tyr Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg 
                85                  90                  95      


Asn 
    


<210>  5
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  5

Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile 
1               5                   10                  15      


Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp 
            20                  25                  30          


Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu 
        35                  40                  45              


Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr 
    50                  55                  60                  


Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln 
65                  70                  75                  80  


Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp 
                85                  90                  95      


Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn 
            100                 105                 110         


Leu Gln Glu Ser Leu Arg Ser Lys Glu 
        115                 120     


<210>  6
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  6

His Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Ile 
1               5                   10                  15      


Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser Ser Ala Ala Trp 
            20                  25                  30          


Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu Tyr Gln Gln Leu 
        35                  40                  45              


Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly Val Glu Glu Thr 
    50                  55                  60                  


Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln 
65                  70                  75                  80  


Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp 
                85                  90                  95      


Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser Phe Ser Thr Asn 
            100                 105                 110         


Leu Gln Lys Arg Leu Arg Arg Lys Asp 
        115                 120     


<210>  7
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MuIFN-gamma(95-132)

<400>  7

Ala Lys Phe Glu Val Asn Asn Pro Gln Val Gln Arg Gln Ala Phe Asn 
1               5                   10                  15      


Glu Leu Ile Arg Val Val His Gln Leu Leu Pro Glu Ser Ser Leu Arg 
            20                  25                  30          


Lys Arg Lys Arg Ser Arg 
        35              


<210>  8
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  huIFN-gamma (95-134) peptide

<400>  8

Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile 
1               5                   10                  15      


His Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr 
            20                  25                  30          


Gly Lys Arg Lys Arg Ser Gln Met 
        35                  40  


<210>  9
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Tkip peptide

<400>  9

Trp Leu Val Phe Phe Val Ile Phe Tyr Phe Phe Arg 
1               5                   10          


<210>  10
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SOCS1-KIR peptide

<400>  10

Asp Thr His Phe Arg Thr Phe Arg Ser His Ser Asp Tyr Arg Arg Ile 
1               5                   10                  15      


<210>  11
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  12
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  13
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  a histone H3 peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  PHOSPHORYLATION

<400>  13

Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala Leu 
1               5                   10                  15      


Arg Glu Ile Arg 
            20  


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  a primer for amplifying human OAS1 promoter region

<400>  14
cattgacagg agagagagtg                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  a primer for amplifying human OAS1 promoter region

<400>  15
tcaggggagt gtctgatttg                                                   20


<210>  16
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  a primer for amplifying human beta-actin promoter region

<400>  16
ctcgctctcg ctcttttttt ttttc                                             25


<210>  17
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  a primer for amplifying human beta-actin promoter region

<400>  17
ctcgagccat aaaaggcaac t                                                 21


<210>  18
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  a nuclear localization sequence of IFNAR2

<400>  18

Arg Lys Lys Lys 
1               


<210>  19
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide PTD

<400>  19

Arg Gln Ile Lys Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15  


<210>  20
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide TAT

<400>  20

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  21
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide SynB1

<400>  21

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  22
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide SynB3

<400>  22

Arg Arg Leu Ser Tyr Ser Arg Arg Arg Phe 
1               5                   10  


<210>  23
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide PTD-4

<400>  23

Pro Ile Arg Arg Arg Lys Lys Leu Arg Arg Leu Lys 
1               5                   10          


<210>  24
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide PTD-5

<400>  24

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  25
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide FHV Coat-(35-49)

<400>  25

Arg Arg Arg Arg Asn Arg Thr Arg Arg Asn Arg Arg Arg Val Arg 
1               5                   10                  15  


<210>  26
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide BMV Gag-(7-25)

<400>  26

Lys Met Thr Arg Ala Gln Arg Arg Ala Ala Ala Arg Arg Asn Arg Trp 
1               5                   10                  15      


Thr Ala Arg 
            


<210>  27
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide HTLV-II Rex-(4-16)

<400>  27

Thr Arg Arg Gln Arg Thr Arg Arg Ala Arg Arg Asn Arg 
1               5                   10              


<210>  28
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide D-Tat

<400>  28

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  29
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide R9-Tat

<400>  29

Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  30
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide Transportan

<400>  30

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  31
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide MAP

<400>  31

Lys Leu Ala Leu Lys Leu Ala Leu Lys Leu Ala Leu Ala Leu Lys Leu 
1               5                   10                  15      


Ala 
    


<210>  32
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide SBP

<400>  32

Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  33
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide FBP

<400>  33

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  34
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide MPG

<400>  34

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  35
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide MPG(delta-NLS)

<400>  35

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Ser Lys Arg Lys Val 
            20                  25          


<210>  36
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide Pep-1

<400>  36

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  37
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell-penetrating peptide Pep-2

<400>  37

Lys Glu Thr Trp Phe Glu Thr Trp Phe Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


