                         SEQUENCE LISTING

<110>  Berggren, Per Olof  
       Shao-Nian Yang

<120>  Methods for Treating and Limiting Diabetes

<130>  150-299

<140>  US 61/501,480
<141>  June 27, 2011


<160>  8     

<170>  PatentIn version 3.1

<210>  1
<211>  487
<212>  DNA
<213>  Homo sapiens

<220>
<221>  CDS
<222>  (1)..(300)
<223>  

<400>  1
atg cag ccc cgg gta ctc ctt gtt gtt gcc ctc ctg gcg ctc ctg gcc       48
Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu Leu Ala         
1               5                   10                  15              

tct gcc cga gct tca gag gcc gag gat gcc tcc ctt ctc agc ttc atg       96
Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met         
            20                  25                  30                  

cag ggt tac atg aag cac gcc acc aag acc gcc aag gat gca ctg agc      144
Gln Gly Tyr Met Lys His Ala Thr Lys Thr Ala Lys Asp Ala Leu Ser         
        35                  40                  45                      

agc gtg cag gag tcc cag gtg gcc cag cag gcc agg ggc tgg gtg acc      192
Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp Val Thr         
    50                  55                  60                          

gat ggc ttc agt tcc ctg aaa gac tac tgg agc acc gtt aag gac aag      240
Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys Asp Lys         
65                  70                  75                  80          

ttc tct gag ttc tgg gat ttg gac cct gag gtc aga cca act tca gcc      288
Phe Ser Glu Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Thr Ser Ala         
                85                  90                  95              

gtg gct gcc tga gacctcaata ccccaagtcc acctgcctat ccatcctgcc          340
Val Ala Ala                                                             
                                                                        

agctccttgg gtcctgcaat ctccagggct gcccctgtag gttgcttaaa agggacagta    400

ttctcagtgc tctcctaccc cacctcatgc ctggcccccc tccaggcatg ctggcctccc    460

aataaagctg gacaagaagc tgctatg                                        487


<210>  2
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Pro Arg Val Leu Leu Val Val Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ser Ala Arg Ala Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met 
            20                  25                  30          


Gln Gly Tyr Met Lys His Ala Thr Lys Thr Ala Lys Asp Ala Leu Ser 
        35                  40                  45              


Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp Val Thr 
    50                  55                  60                  


Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys Asp Lys 
65                  70                  75                  80  


Phe Ser Glu Phe Trp Asp Leu Asp Pro Glu Val Arg Pro Thr Ser Ala 
                85                  90                  95      


Val Ala Ala 
            


<210>  3
<211>  2509
<212>  DNA
<213>  Rattus norvegicus

<400>  3
taaagagacg gatgacctac agccccaggc ccacccattc aacaggccta gctcattccc     60

aagcccagac atcaaggcat gggacaccca cgcatggcag cttcgtgtcc agctttatta    120

gggacagcat gtttaggtga ggtctgggga gggataaagg catgagaata tactttcccc    180

ttagagcaac cttcggaggc agcaggatag atggccagac acatctggaa catggaggtc    240

tcacggctca agagttggtg ttgttagttg gtcctcaggg ccagactccc agaggccagt    300

gaacttatca gtgaacttgc tccagtagcc tttcagggat ttgaagcgat tgtccatcca    360

gcccctgggg gttaaaacag taataggtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt    420

gtgtgtgtgt gtgtgtgtgt gaaaagatct cctgtgggca gctagaccca ggggtgcacc    480

taggcctcca ctggctccct aagccaccag caccacctta cctagcacca ccctcagaat    540

cacctgcagc taccactcaa ggtggaggag atggtaaagg ctaagaaaac ccaccttcat    600

cagagcccca ttacctcccg tccaatctct cttcaggcct gaggcaccaa ccactgggga    660

ggtggatact aaggtcagct tgcctttgta gtccatagaa acagtgtcct tgaggtgtcc    720

catccctggc tctaagtgga tggatcaagg gaggggtgaa ctttctgttt ggaaacatta    780

ccagagggct tctaagctct gtgatctagg ccaggttatc taactctttc ccagctgcgg    840

aggtagatag tacctctcca caacctgttc tgggcacaga gactgtcaac atcttttgct    900

acataggcaa tgatcaaatg tcacgtaaac gattggcagg gtaatgtttc atcacgggca    960

agatgcctca cttaggttga gcccagggat ggaaacaggg cagaaccccc aacccgtaat   1020

gctcaacctt ccaacttccc tgtaatcaga gcaggaaggc ctcccagagc acaccctaga   1080

ccctgtgctc aaagaagaaa acctgcaggg aggctgaacg ctcctcaggc tgctctgagg   1140

agaagcagag gagatagaag aagtctgctt gcactgcctg tcatcttagt cacagtcccc   1200

agcaaaggcc ccgtgagaga ctggatgctc agacgggccc aagaccctgg taaacttggt   1260

gggccacagt ctccgtgtcc agggcctcag caccagggca ggaggggcga ggaccaggaa   1320

aggaggtccg tgtgcatacc tggccaccac agctatatca gactcctgca tgctgcttag   1380

tgcatcctgg accgtcttgg aggcttgttc catgtagccc tgcatagagc ccagcagcaa   1440

ggatccctct ccctcatcag ctcctgcaag agagcagagt tgagccaggc cagccctcag   1500

ctcttgccca gccatcgctt ttcagggtag ggtccccaga ccagctcccg cagaaatccc   1560

agccccactt ccaccagctt acgggcagag gccaggagag ccacgagggc cacgatgagg   1620

agcattcggg gctgcatggc acctgtgcac ctgcgggaga ccatcttgtg agagggtatt   1680

gtggatctcc acatctaagc ccttccctgg agaacaccac ggcccctctg tcatgaatcc   1740

ccaagccttt ctcctactga tatcagctct cggagagaga actaagaaga cccagaccca   1800

ccccaagggg ctggaaggtg gaatgtggga atcctctgca aagcagaaca tctacccagc   1860

ctctgcccca atatatggag aaacaacagg tttctttttc tctctaggct tcaggctttt   1920

cagtctgggg taggcacgga tatcaaaggc ttctaatagc tcagagcaag acgaacaagg   1980

ggcagcatga cccagttccc aatcagctct gccactaccc agtgcaaggc ttttttgccc   2040

agtggcctcc ctttcctcag cttctagcct cccccaccca ccaggatacc caagggctgg   2100

aggccgtgaa ttccaagcat tctgtaggct agctggctga gtggccagag cgtcttctct   2160

ctgtctcctc cctcccttcc tctcctcccc aggggcatta cctggagtag ctagctgctt   2220

ctagggataa aactgggcag gcaagccggg acgctctgat ctgttttata ttggctccag   2280

gatgggacag cgggcacaga aggcccagtg agctggtcaa aggtcacctg ctgaacagtc   2340

cagaccagag cccgaggcag ggaggccatg cagccagctg ccagaggagt tgagaaatcc   2400

ctcagagatt gcccacaccg ttcacttcca cctccgcagc caagagatca gctactgacc   2460

tgcctcgatg agactggtga gacaggaaaa gactcagggg acaagcctt               2509


<210>  4
<211>  101
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Met Gln Pro Arg Met Leu Leu Ile Val Ala Leu Val Ala Leu Leu Ala 
1               5                   10                  15      


Ser Ala Arg Ala Asp Glu Gly Glu Gly Ser Leu Leu Leu Gly Ser Met 
            20                  25                  30          


Gln Gly Tyr Met Glu Gln Ala Ser Lys Thr Val Gln Asp Ala Leu Ser 
        35                  40                  45              


Ser Met Gln Glu Ser Asp Ile Ala Val Val Ala Ser Arg Gly Trp Met 
    50                  55                  60                  


Asp Asn Arg Phe Lys Ser Leu Lys Gly Tyr Trp Ser Lys Phe Thr Asp 
65                  70                  75                  80  


Lys Phe Thr Gly Leu Trp Glu Ser Gly Pro Glu Asp Gln Leu Thr Thr 
                85                  90                  95      


Pro Thr Leu Glu Pro 
            100     


<210>  5
<211>  3262
<212>  DNA
<213>  Macaca fascicularis

<220>
<221>  CDS
<222>  (858)..(912)
<223>  

<220>
<221>  CDS
<222>  (1048)..(1171)
<223>  

<220>
<221>  CDS
<222>  (2871)..(2988)
<223>  

<400>  5
ctgcagggct ggcgggacag cagcatggac acagtctcct ggggatttcc caactctccc     60

gccagcttgc tgcctctggc cgccctgcct caggccctgg tctctgatca gcaggtgacc    120

tttgcccagt gccctgggtc ctcagtgcct gctgccctgg agacaatata aaacaggctc    180

agaaccctcc tgcctgcctg ctctgttcat ccctagaggc agctgctcca ggtaatgccc    240

tctggggagg ggaaagagga ggggaggagg atgaagagga gcaagaggag ctccctgccc    300

agcccagcca gcaagcctgg agaaacactt gctagagcta aggaagcctc ggagctggac    360

gggtgccccc aacccctcat cataacctga agaaaatgga ggcccgggag gggtgtcact    420

tgcccaaagc tacacagggg gtggggctgg aaatggttcc aagtgcaggc ttccccgtca    480

ttctgcaggc ttagggctgg aggaagcctt agacagccca gtcctaccca gacagggaaa    540

ctgaggcctg gagagggcca gaaagcccca aagtcacaca gcatgttggc tgcactggac    600

agagaccagt ccagaccgca ggtgccttga tgtccagtct ggtgggtttt ctgctccatc    660

ccacctacct ccctttgggc ccctcactag tccccttctg agagcccgta ttagcaggaa    720

gcaggcccct actccctctg gcagaccgag ctcaggtccc accttagggg ccatgccacc    780

tgtccaggga ggggtccaga ggcatggggg cctggggtgc ccctcacagg acaattcctt    840

gcaggaacag aggcgcc atg cag ccc cgg gta ctc ctt gtt gct gcc ctg       890
                   Met Gln Pro Arg Val Leu Leu Val Ala Ala Leu          
                   1               5                   10               

ctg tca ctc ctg gcc tct gcc a gtaagcactt ggtgggactg ggctgggggc       942
Leu Ser Leu Leu Ala Ser Ala                                             
            15                                                          

aggatggagg tggcttgggg atcccagtcc taatgggtgg tcaagcagga gctcagggct   1002

cgcctagagg ccgatccacc actctcagcc ctgctctttc ctcag ga  gct tca gag   1058
                                                  Arg Ala Ser Glu       
                                                      20                

gcc gag gac acc tcc ctt ctt ggc ttc atg cag ggc tac atg cag cat     1106
Ala Glu Asp Thr Ser Leu Leu Gly Phe Met Gln Gly Tyr Met Gln His         
        25                  30                  35                      

gcc acc aag acc gcc aag gat gca ctg acc agc gtc cag gag tcc cag     1154
Ala Thr Lys Thr Ala Lys Asp Ala Leu Thr Ser Val Gln Glu Ser Gln         
    40                  45                  50                          

gtg gcc cag cag gcc ag  gtacacccgc tggcctccct ccccatccct            1201
Val Ala Gln Gln Ala Arg                                                 
55                                                                      

catgccagct ccctccattc ccacccgccc tgccctggtg agatcccagc aatggaatgg   1261

aggtgccagc ctcccctggt cctgtgcctc tttggcctcc tctttcctca cagggccttg   1321

gtcaggctgc tgtgggagag acgacagagt tgagactgcg ttccccccgg gtccctcctt   1381

tctcccagag cagttctagg gtgggccatt ttagccctca tttccatttt cctttccttt   1441

tctttctttt tcttttcttt ttttttcttt ctttcttttt tttttttgag atggagtctc   1501

cctctgtcac ccaggctaga gtgcagtggt gcgatctcag cggatctcgg ctcactgcaa   1561

cctctgcctc ccaggttcac cccattctcc tgcctcagcc tcccaagtag ctgggattac   1621

aggcgtgcca ccacatccag ctactttttg tatttttctc agagacgggg tttccccatg   1681

ttggacaggc tggtcttgaa ctcctgacct caggtgatct gcctacctcg gcctcccaaa   1741

ttgctgggat tacaggcatg agccactgcg cctgacccca ttttcctttt ctgaaggtct   1801

ggctagagca gaggtcctca acctttttgg caccagggac cagttttgtg gtagacagtt   1861

tttccatggg tcagcgggga tggcttgggg atgaaactgc tccacctcag atcaccaggc   1921

attggattct cctaagaagc cctccacccc gacccctggc atgcgcagtt cacaacaggt   1981

ttcacactcc tgtgagaatc taatgccgcc taacctgaca gaaggcgggg cttgggcggt   2041

attcctctgt cacccatcac tcactttgtg ctgtgcagcc tggctcctaa ctggccatgg   2101

accagtaccc atctgtgact tgggggctgg ggacccctgg gctaggggtt tgccttggga   2161

ggccccacct ggcccaattc tagcctgggt atgagagtgc ttctgctttg ttccaagacc   2221

tggggccagg gtgagtagaa gtgtgtcctt cctctcccat cctgcccctg cccatcggtc   2281

ctctcctctc cctactccct tccccacctc accctgactg gcattggctg gcatagcaga   2341

ggttgtttat aagcattctt aatcctcaga accggctttg gggtaggtgt tattttccca   2401

ctttgcagat gagaaaattg aggctcagag cgattaggtg acctgcccca gatcacacaa   2461

ctaatcaatc ctccaatgac tttccaaatg agaggtcgcc tccctctgtc ctaccctgct   2521

cggaaccacc aggatataca actccagggg atactgtctg cacagaaaac aatgacagcc   2581

ttgacctttc acatctcccc accctgtcac tctgtgcctc aagcccaggg gcaaaaacat   2641

ctgaggtcac ctggagacgg cagggttcga cttgtgctgg ggttcctgta agggcatctc   2701

ttctcccagg gtggcagctg tgggcagtcc tgcctgaggt ctcagggctg ttgtccagtg   2761

aagttgagag ggtggcaggg agagccagtg gggacatggg tgtgggtccc atagttgcct   2821

ccaaaggagt tctcatgccc tgctctgttg cttcccctta ctgatttag a ggc tgg     2877
                                                        Gly Trp         
                                                                        

gtg acc gat ggc ttc agt tcc ctg aaa gac tac tgg agc acc gtt aag     2925
Val Thr Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys         
        65                  70                  75                      

gac aag tta tct ggg ttc tgg gat ttg aac cct gag gcc aaa ccc act     2973
Asp Lys Leu Ser Gly Phe Trp Asp Leu Asn Pro Glu Ala Lys Pro Thr         
    80                  85                  90                          

ctg gct gag gct gcc tgagacctca ataccccaag tccacctgcc tgtccatcct     3028
Leu Ala Glu Ala Ala                                                     
95                                                                      

gccagctcct tgggtcctgc agcctccagg gctgcccctg taggttgctt aaaagggaca   3088

gtattctcag tgccctccta ccgcacctca tgcctggccc ccctccaggc agggtgtcct   3148

cccaataaag ctggacaaga agctgctatg agtgggccgt cacaagtgtg ccatctgtgt   3208

ctgggtatgg gaaagggtcc gaggctgttc tgtgggtagg cactggacga ctgc         3262


<210>  6
<211>  99
<212>  PRT
<213>  Macaca fascicularis

<400>  6

Met Gln Pro Arg Val Leu Leu Val Ala Ala Leu Leu Ser Leu Leu Ala 
1               5                   10                  15      


Ser Ala Arg Ala Ser Glu Ala Glu Asp Thr Ser Leu Leu Gly Phe Met 
            20                  25                  30          


Gln Gly Tyr Met Gln His Ala Thr Lys Thr Ala Lys Asp Ala Leu Thr 
        35                  40                  45              


Ser Val Gln Glu Ser Gln Val Ala Gln Gln Ala Arg Gly Trp Val Thr 
    50                  55                  60                  


Asp Gly Phe Ser Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys Asp Lys 
65                  70                  75                  80  


Leu Ser Gly Phe Trp Asp Leu Asn Pro Glu Ala Lys Pro Thr Leu Ala 
                85                  90                  95      


Glu Ala Ala 
            


<210>  7
<211>  2411
<212>  DNA
<213>  Mus musculus

<220>
<221>  CDS
<222>  (54)..(350)
<223>  

<400>  7
gctacatcag gggctgtgca gcgtcgccca tactccgagc aaagaactgt ggc cag        56
                                                           Gln          
                                                           1            

agg cag tcg agg tta gtg agg act gcg agg cag aca ctt tgc tgt gtt      104
Arg Gln Ser Arg Leu Val Arg Thr Ala Arg Gln Thr Leu Cys Cys Val         
            5                   10                  15                  

caa atc caa gtc aag ggt aca aaa atg cag agc aat aaa gcc ttt aac      152
Gln Ile Gln Val Lys Gly Thr Lys Met Gln Ser Asn Lys Ala Phe Asn         
        20                  25                  30                      

ttg gag aag cag aat cat act cca agg aag cat cat cag cat cac cac      200
Leu Glu Lys Gln Asn His Thr Pro Arg Lys His His Gln His His His         
    35                  40                  45                          

cag cag cac cat cag cag caa cag cag cag cag cag caa cag cca ccc      248
Gln Gln His His Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro         
50                  55                  60                  65          

cca cca ata cct gca aat ggc cag cag gcc agc agc cag aat gaa ggc      296
Pro Pro Ile Pro Ala Asn Gly Gln Gln Ala Ser Ser Gln Asn Glu Gly         
                70                  75                  80              

ttg act att gac ctg aag aat ttt agg aaa cca gga gag aag acc ttt      344
Leu Thr Ile Asp Leu Lys Asn Phe Arg Lys Pro Gly Glu Lys Thr Phe         
            85                  90                  95                  

aca cag cgtagccgtc tctttgtggg caatcttccc cctgatatca ctgaggagga       400
Thr Gln                                                                 
                                                                        

aatgaggaaa ctatttgaga aatatggaaa agcaggcgaa gttttcattc ataaggataa    460

aggctttggc tttattcgct tggaaacacg aaccctagcg gaaattgtca aagtggagct    520

ggacaacatg cccctccgtg ggaagcagct gcgagtgcgc ttcgcctgtc acagtgcatc    580

ccttacagtc cgcaaccttc ctcagtacgt gtcgaacgaa ctgctggaag aagccttttc    640

tgtgttcggc caggtggaga gggctgtagt cattgtggat gaccgaggaa ggccctcagg    700

gaaaggcatt gttgagttct cagggaagcc agctgctcgg aaagctctgg acagatgcag    760

tgaaggctcc ttcttgctga ctacatttcc ttggcctgtg actgtggagc ctatggacca    820

gttagatgat gaagagggac ttccagagaa actggttata aaaaaccagc aattccacaa    880

ggagagagaa cagccaccca gatttgcaca acctggctcc tttgagtatg agtatgccat    940

gcgctggaag gcactcattg agatggagaa gcaacagcag gatcaagtgg atcggaacat   1000

caaggaggct cgtgagaagc tggagatgga gatggaggct gcacgtcatg agcaccaggt   1060

tatgctaatg aggcaggatt tgatgagacg tcaagaagag cttcggagaa tggaggagct   1120

gcataaccaa gaggttcaga agcgaaagca gttagaactc aggcaggaag aggaacgcag   1180

gcgccgtgag gaagagatgc ggcgacaaca agaggaaatg atgcgccgac agcaggaagg   1240

attcaaggga accttccctg atgcgagaga acaagagata cggatgggcc aaatggctat   1300

gggaggtgct atgggcataa acaatagagg cgcgatgccc cctgctcctg tgccacctgg   1360

tactccagct cctccaggac ctgccactat gatgccagat ggaacccttg gattgacccc   1420

accaacaact gaacgttttg gccaagctgc aacaatggaa ggaattggag caattggtgg   1480

aactcctcct gcattcaacc gtccagctcc gggagctgaa tttgctccaa ataaacgccg   1540

ccgatattag ataaagttgc attgtctagt ttcctgcagc ccttaaaaga agggcccttt   1600

ttggactagc cagaattcta ccctggaaaa gtgttagggg ttcttcccaa tagataggcc   1660

ttccctgctt gtactactct agggatcatg cttgaagtca gaggggcaga gaaggggtgg   1720

tattcaacaa gtcaaagtct gtggtatatt gctttatcaa gactgtctgg tgcattcctg   1780

aactatatta attgttgagg gcctggagaa ccatgggaaa atgaactcag agctccatta   1840

atcttgatca ttccttctct ctctttctct ctctcttgtt ttaattactt tctcatcttt   1900

attcccctca acccctgaga cactgccata tataccacaa accataaaca tcctccaatg   1960

acctagcccc atccctccat tcactcccag gtaagaattc agacaaatgt ccacagaggt   2020

tacagcatac gtacggttgt gttatatctc atatatgacc ccttcatgtc ctaaggaaga   2080

cattttctct tagaggtttt cattttagta tatcttaaaa gaatcttgtg ttaccttgcc   2140

tccatctttt tcttgggtaa ggactacact ttgtgtctct gatgttgctg ttcacagctt   2200

ttcttgatag gcctagtaca atcttgggaa cagggttgct gtgtggtgaa ggtctgacag   2260

tagttcttag tcttgcctat cttaggtagc tacgctgtgc atttttattg gtatactatg   2320

aattgttcca gataccttca gtttggaaag ttttctgaga aatggagacg tcatgcggca   2380

tcaccttatt aaaatgcatt tgaagccttt t                                  2411


<210>  8
<211>  99
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Arg Gln Ser Arg Leu Val Arg Thr Ala Arg Gln Thr Leu Cys Cys 
1               5                   10                  15      


Val Gln Ile Gln Val Lys Gly Thr Lys Met Gln Ser Asn Lys Ala Phe 
            20                  25                  30          


Asn Leu Glu Lys Gln Asn His Thr Pro Arg Lys His His Gln His His 
        35                  40                  45              


His Gln Gln His His Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro 
    50                  55                  60                  


Pro Pro Pro Ile Pro Ala Asn Gly Gln Gln Ala Ser Ser Gln Asn Glu 
65                  70                  75                  80  


Gly Leu Thr Ile Asp Leu Lys Asn Phe Arg Lys Pro Gly Glu Lys Thr 
                85                  90                  95      


Phe Thr Gln 
            


