                         SEQUENCE LISTING

<110>  THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS 
       REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND 
       HUMAN SERVICES
       Chang, Gwong-Jen J.
       Hughes, Holly R.
 
<120>  IDENTIFICATION OF A WEST NILE VIRUS CD4 T CELL EPITOPE AND USE 
       THEREOF FOR IMPROVING IMMUNOGENICITY OF VACCINES

<130>  6395-86466-02

<150>  US 61/506,934
<151>  2011-07-12

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  1
gtctcgtgcg tttatgccca tccagagcag tagggc                                 36


<210>  2
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  2
cacaccccct gtggctaaga aggtcaaagc attgatcg                               38


<210>  3
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  3
gaacacgagc acacccccta cggctaagaa ggtc                                   34


<210>  4
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  4
gcacattggt cgctaagaac aggagcacac cccc                                   34


<210>  5
<211>  36
<212>  PRT
<213>  West Nile virus

<400>  5

Gly Ala Leu Leu Leu Trp Met Gly Ile Asn Ala Arg Asp Arg Ser Ile 
1               5                   10                  15      


Ala Leu Thr Phe Leu Ala Val Gly Gly Val Leu Leu Phe Leu Ser Val 
            20                  25                  30          


Asn Val His Ala 
        35      


<210>  6
<211>  30
<212>  PRT
<213>  West Nile virus

<400>  6

Gly Ala Leu Leu Leu Trp Met Gly Ile Asn Ala Arg Asp Arg Ser Ile 
1               5                   10                  15      


Ala Leu Thr Phe Leu Ala Val Gly Gly Val Leu Leu Phe Leu 
            20                  25                  30  


<210>  7
<211>  2191
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (73)..(570)
<223>  prM coding sequence

<220>
<221>  misc_feature
<222>  (571)..(1755)
<223>  E coding sequence

<220>
<221>  misc_feature
<222>  (1796)..(1928)
<223>  intron

<220>
<221>  misc_feature
<222>  (1929)..(2188)
<223>  E coding sequence

<400>  7
atgggcaaga ggtccgccgg ctcaatcatg tggctcgcga gcttggcagt tgtcatagct       60

tgtgcaggcg cc ttc cat tta acc aca cgt aac gga gaa cca cac atg atc      111
              Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile         
              1               5                   10                      

gtc agc aga caa gag aaa ggg aaa agt ctt ctg ttt aaa aca gag gat        159
Val Ser Arg Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp           
    15                  20                  25                            

ggc gtg aac atg tgt acc ctc atg gcc atg gac ctt ggt gaa ttg tgt        207
Gly Val Asn Met Cys Thr Leu Met Ala Met Asp Leu Gly Glu Leu Cys           
30                  35                  40                  45            

gaa gac aca atc acg tac aag tgt ccc ctt ctc agg cag aat gag cca        255
Glu Asp Thr Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro           
                50                  55                  60                

gaa gac ata gac tgt tgg tgc aac tct acg tcc acg tgg gta act tat        303
Glu Asp Ile Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr           
            65                  70                  75                    

ggg acg tgt acc acc atg gga gaa cat aga aga gaa aaa aga tca gtg        351
Gly Thr Cys Thr Thr Met Gly Glu His Arg Arg Glu Lys Arg Ser Val           
        80                  85                  90                        

gca ctc gtt cca cat gtg gga atg gga ctg gag aca cga act gaa aca        399
Ala Leu Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr           
    95                  100                 105                           

tgg atg tca tca gaa ggg gcc tgg aaa cat gtc cag aga att gaa act        447
Trp Met Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr           
110                 115                 120                 125           

tgg atc ttg aga cat cca ggc ttc acc atg atg gca gca atc ctg gca        495
Trp Ile Leu Arg His Pro Gly Phe Thr Met Met Ala Ala Ile Leu Ala           
                130                 135                 140               

tac acc ata gga acg aca cat ttc caa aga gcc ctg att ttc atc tta        543
Tyr Thr Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu           
            145                 150                 155                   

ctg aca gct gtc act cct tca atg aca atgcgttgca taggaatgtc              590
Leu Thr Ala Val Thr Pro Ser Met Thr                                       
        160                 165                                           

aaatagagac tttgtggaag gggtttcagg aggaagctgg gttgacatag tcttagaaca      650

tgggagctgt gtgacgacga tggcaaaaaa caaaccaaca ttggattttg aactgataaa      710

aacagaagcc aaacagcctg ccaccctaag gaagtactgt atagaggcaa agctaaccaa      770

cacaacaaca gaatctcgct gcccaacaca aggggaaccc agcctaaatg aagagcagga      830

caaaaggttc gtctgcaaac actccatggt agacagagga tggggaaatg gatgtcgcga      890

ctttggaaag ggaggcattg tgacctgtgc tatgttcaga tgcaaaaaga acatggaagg      950

aaaagttgtg caaccagaaa acttggaata caccattgtg ataacacctc actcagggga     1010

agagcatgca gtcggaaatg acacaggaaa acatggcaag gaaatcaaaa taacaccaca     1070

gagttccatc acagaagcag aattgacagg ttatggcact gtcacaatgg agtgctctcc     1130

aagaacgggc ctcgacttca atgagatggt gttgttgcag atggaaaata aagcttggct     1190

ggtgcacagg caatggttcc tagacctgcc gttaccatgg ttgcccggag cggacacaca     1250

agggtcaaat tggatacaga aagagacatt ggtcactttc aaaaatcccc atgcgaagaa     1310

acaggatgtt gttgttttag gatcccaaga aggggccatg cacacagcac ttacaggggc     1370

cacagaaatc caaatgtcat caggaaactt actcttcaca ggacatctca agtgcaggct     1430

gagaatggac aagctacagc tcaaaggaat gtcatactct atgtgcacag gaaagtttaa     1490

agttgtggag cgaatagcag aaacacaaca tggaacaata gttatcagag tgcaatatga     1550

aggggacggc tctccatgca agatcccttt tgagataatg gatttggaaa aaagacatgt     1610

cttaggtcgc ctgattacag tcaacccaat tgtgacagaa aaagatagcc gggtcaacat     1670

agaagcagaa cctccattcg gagacagcta catcatcata ggagtagagc cgggacaact     1730

gaagctcaac tggtttaaga aaggaagcac gctgggcaag gccttttcaa caactttgaa     1790

gggaggtaag tatcaaggtt acaagacagg tttaaggaga ccaatagaaa ctgggcttgt     1850

cgagacagag aagactcttg cgtttctgat aggcacctat tggtcttact gacatccact     1910

ttgcctttct ctccacagct caaagactgg cagcgttggg cgacacagcc tgggactttg     1970

gctctattgg aggggtcttc aactccatag gaaaagccgt tcaccaagtg tttggtggtg     2030

ccttcagaac actctttggg ggaatgtctt ggatcacaca agggctaatg ggtgccctac     2090

tgctctggat gggcgtcaac gcacgagacc gatcaattgc tttggccttc ttagccacag     2150

ggggtgtgct cgtgttctta gcgaccaatg tgcatgctta a                         2191


<210>  8
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val Ser Arg 
1               5                   10                  15      


Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp Gly Val Asn 
            20                  25                  30          


Met Cys Thr Leu Met Ala Met Asp Leu Gly Glu Leu Cys Glu Asp Thr 
        35                  40                  45              


Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu Asp Ile 
    50                  55                  60                  


Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly Thr Cys 
65                  70                  75                  80  


Thr Thr Met Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala Leu Val 
                85                  90                  95      


Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp Met Ser 
            100                 105                 110         


Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr Trp Ile Leu 
        115                 120                 125             


Arg His Pro Gly Phe Thr Met Met Ala Ala Ile Leu Ala Tyr Thr Ile 
    130                 135                 140                 


Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu Thr Ala 
145                 150                 155                 160 


Val Thr Pro Ser Met Thr 
                165     


<210>  9
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENV2 RDERR E protein

<400>  9

Met Arg Cys Ile Gly Met Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Arg Asp Phe Gly Lys Gly Gly 
            100                 105                 110         


Ile Val Thr Cys Ala Met Phe Arg Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             


Val Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His 
    130                 135                 140                 


Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 


Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     


Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Gln Met Glu Asn Lys Ala Trp Leu Val 
        195                 200                 205             


His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 


Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 


Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         


Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             


Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 


Lys Phe Lys Val Val Glu Arg Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 


Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         


Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Arg Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 


Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly Ser Thr Leu Gly Lys 
385                 390                 395                 400 


Ala Phe Ser Thr Thr Leu Lys Gly Ala Gln Arg Leu Ala Ala Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Asn Ser Ile 
            420                 425                 430         


Gly Lys Ala Val His Gln Val Phe Gly Gly Ala Phe Arg Thr Leu Phe 
        435                 440                 445             


Gly Gly Met Ser Trp Ile Thr Gln Gly Leu Met Gly Ala Leu Leu Leu 
    450                 455                 460                 


Trp Met Gly Val Asn Ala Arg Asp Arg Ser Ile Ala Leu Ala Phe Leu 
465                 470                 475                 480 


Ala Thr Gly Gly Val Leu Val Phe Leu Ala Thr Asn Val His Ala 
                485                 490                 495 


<210>  10
<211>  2191
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  CDS
<222>  (73)..(570)
<223>  prM coding sequence

<220>
<221>  misc_feature
<222>  (571)..(1795)
<223>  E coding sequence

<220>
<221>  misc_feature
<222>  (1796)..(1928)
<223>  intron

<220>
<221>  misc_feature
<222>  (1929)..(2188)
<223>  E coding sequence

<400>  10
atgggcaaga ggtccgccgg ctcaatcatg tggctcgcga gcttggcagt tgtcatagct       60

tgtgcaggcg cc ttc cat tta acc aca cgt aac gga gaa cca cac atg atc      111
              Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile         
              1               5                   10                      

gtc agc aga caa gag aaa ggg aaa agt ctt ctg ttt aaa aca gag gat        159
Val Ser Arg Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp           
    15                  20                  25                            

ggc gtg aac atg tgt acc ctc atg gcc atg gac ctt ggt gaa ttg tgt        207
Gly Val Asn Met Cys Thr Leu Met Ala Met Asp Leu Gly Glu Leu Cys           
30                  35                  40                  45            

gaa gac aca atc acg tac aag tgt ccc ctt ctc agg cag aat gag cca        255
Glu Asp Thr Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro           
                50                  55                  60                

gaa gac ata gac tgt tgg tgc aac tct acg tcc acg tgg gta act tat        303
Glu Asp Ile Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr           
            65                  70                  75                    

ggg acg tgt acc acc atg gga gaa cat aga aga gaa aaa aga tca gtg        351
Gly Thr Cys Thr Thr Met Gly Glu His Arg Arg Glu Lys Arg Ser Val           
        80                  85                  90                        

gca ctc gtt cca cat gtg gga atg gga ctg gag aca cga act gaa aca        399
Ala Leu Val Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr           
    95                  100                 105                           

tgg atg tca tca gaa ggg gcc tgg aaa cat gtc cag aga att gaa act        447
Trp Met Ser Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr           
110                 115                 120                 125           

tgg atc ttg aga cat cca ggc ttc acc atg atg gca gca atc ctg gca        495
Trp Ile Leu Arg His Pro Gly Phe Thr Met Met Ala Ala Ile Leu Ala           
                130                 135                 140               

tac acc ata gga acg aca cat ttc caa aga gcc ctg att ttc atc tta        543
Tyr Thr Ile Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu           
            145                 150                 155                   

ctg aca gct gtc act cct tca atg aca atgcgttgca taggaatgtc              590
Leu Thr Ala Val Thr Pro Ser Met Thr                                       
        160                 165                                           

aaatagagac tttgtggaag gggtttcagg aggaagctgg gttgacatag tcttagaaca      650

tgggagctgt gtgacgacga tggcaaaaaa caaaccaaca ttggattttg aactgataaa      710

aacagaagcc aaacagcctg ccaccctaag gaagtactgt atagaggcaa agctaaccaa      770

cacaacaaca gaatctcgct gcccaacaca aggggaaccc agcctaaatg aagagcagga      830

caaaaggttc gtctgcaaac actccatggt agacagagga tggggaaatg gatgtcgcga      890

ctttggaaag ggaggcattg tgacctgtgc tatgttcaga tgcaaaaaga acatggaagg      950

aaaagttgtg caaccagaaa acttggaata caccattgtg ataacacctc actcagggga     1010

agagcatgca gtcggaaatg acacaggaaa acatggcaag gaaatcaaaa taacaccaca     1070

gagttccatc acagaagcag aattgacagg ttatggcact gtcacaatgg agtgctctcc     1130

aagaacgggc ctcgacttca atgagatggt gttgttgcag atggaaaata aagcttggct     1190

ggtgcacagg caatggttcc tagacctgcc gttaccatgg ttgcccggag cggacacaca     1250

agggtcaaat tggatacaga aagagacatt ggtcactttc aaaaatcccc atgcgaagaa     1310

acaggatgtt gttgttttag gatcccaaga aggggccatg cacacagcac ttacaggggc     1370

cacagaaatc caaatgtcat caggaaactt actcttcaca ggacatctca agtgcaggct     1430

gagaatggac aagctacagc tcaaaggaat gtcatactct atgtgcacag gaaagtttaa     1490

agttgtggag cgaatagcag aaacacaaca tggaacaata gttatcagag tgcaatatga     1550

aggggacggc tctccatgca agatcccttt tgagataatg gatttggaaa aaagacatgt     1610

cttaggtcgc ctgattacag tcaacccaat tgtgacagaa aaagatagcc gggtcaacat     1670

agaagcagaa cctccattcg gagacagcta catcatcata ggagtagagc cgggacaact     1730

gaagctcaac tggtttaaga aaggaagcac gctgggcaag gccttttcaa caactttgaa     1790

gggaggtaag tatcaaggtt acaagacagg tttaaggaga ccaatagaaa ctgggcttgt     1850

cgagacagag aagactcttg cgtttctgat aggcacctat tggtcttact gacatccact     1910

ttgcctttct ctccacagct caaagactgg cagcgttggg cgacacagcc tgggactttg     1970

gctctattgg aggggtcttc aactccatag gaaaagccgt tcaccaagtg tttggtggtg     2030

ccttcagaac actctttggg ggaatgtctt ggatcacaca agggctaatg ggtgccctac     2090

tgctctggat gggcataaac gcacgagacc gatcaattgc tttgaccttc ttagccgtag     2150

ggggtgtgct cctgttctta gcgaccaatg tgcatgctta a                         2191


<210>  11
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Phe His Leu Thr Thr Arg Asn Gly Glu Pro His Met Ile Val Ser Arg 
1               5                   10                  15      


Gln Glu Lys Gly Lys Ser Leu Leu Phe Lys Thr Glu Asp Gly Val Asn 
            20                  25                  30          


Met Cys Thr Leu Met Ala Met Asp Leu Gly Glu Leu Cys Glu Asp Thr 
        35                  40                  45              


Ile Thr Tyr Lys Cys Pro Leu Leu Arg Gln Asn Glu Pro Glu Asp Ile 
    50                  55                  60                  


Asp Cys Trp Cys Asn Ser Thr Ser Thr Trp Val Thr Tyr Gly Thr Cys 
65                  70                  75                  80  


Thr Thr Met Gly Glu His Arg Arg Glu Lys Arg Ser Val Ala Leu Val 
                85                  90                  95      


Pro His Val Gly Met Gly Leu Glu Thr Arg Thr Glu Thr Trp Met Ser 
            100                 105                 110         


Ser Glu Gly Ala Trp Lys His Val Gln Arg Ile Glu Thr Trp Ile Leu 
        115                 120                 125             


Arg His Pro Gly Phe Thr Met Met Ala Ala Ile Leu Ala Tyr Thr Ile 
    130                 135                 140                 


Gly Thr Thr His Phe Gln Arg Ala Leu Ile Phe Ile Leu Leu Thr Ala 
145                 150                 155                 160 


Val Thr Pro Ser Met Thr 
                165     


<210>  12
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DENV2 RDERR-TMD E protein

<400>  12

Met Arg Cys Ile Gly Met Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Arg Asp Phe Gly Lys Gly Gly 
            100                 105                 110         


Ile Val Thr Cys Ala Met Phe Arg Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             


Val Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His 
    130                 135                 140                 


Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 


Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     


Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Gln Met Glu Asn Lys Ala Trp Leu Val 
        195                 200                 205             


His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 


Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 


Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         


Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             


Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 


Lys Phe Lys Val Val Glu Arg Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 


Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         


Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Arg Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 


Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly Ser Thr Leu Gly Lys 
385                 390                 395                 400 


Ala Phe Ser Thr Thr Leu Lys Gly Ala Gln Arg Leu Ala Ala Leu Gly 
                405                 410                 415     


Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Asn Ser Ile 
            420                 425                 430         


Gly Lys Ala Val His Gln Val Phe Gly Gly Ala Phe Arg Thr Leu Phe 
        435                 440                 445             


Gly Gly Met Ser Trp Ile Thr Gln Gly Leu Met Gly Ala Leu Leu Leu 
    450                 455                 460                 


Trp Met Gly Ile Asn Ala Arg Asp Arg Ser Ile Ala Leu Thr Phe Leu 
465                 470                 475                 480 


Ala Val Gly Gly Val Leu Leu Phe Leu Ala Thr Asn Val His Ala 
                485                 490                 495 


<210>  13
<211>  81
<212>  PRT
<213>  Dengue virus type 2

<400>  13

Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr 
1               5                   10                  15      


Ser Ile Gly Lys Ala Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala 
            20                  25                  30          


Ala Phe Ser Gly Val Ser Trp Thr Met Lys Ile Leu Ile Gly Val Ile 
        35                  40                  45              


Ile Thr Trp Ile Gly Met Asn Ser Arg Ser Thr Ser Leu Ser Val Ser 
    50                  55                  60                  


Leu Val Leu Val Gly Val Val Thr Leu Tyr Leu Gly Ala Met Val Gln 
65                  70                  75                  80  


Ala 
    


<210>  14
<211>  81
<212>  PRT
<213>  Dengue virus type 1

<400>  14

Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Thr 
1               5                   10                  15      


Ser Val Gly Lys Leu Ile His Gln Ile Phe Gly Thr Ala Tyr Gly Val 
            20                  25                  30          


Leu Phe Ser Gly Val Ser Trp Thr Met Lys Ile Gly Ile Gly Ile Leu 
        35                  40                  45              


Leu Thr Trp Leu Gly Leu Asn Ser Arg Ser Thr Ser Leu Ser Met Thr 
    50                  55                  60                  


Cys Ile Ala Val Gly Met Val Thr Leu Tyr Leu Gly Val Met Val Gln 
65                  70                  75                  80  


Ala 
    


<210>  15
<211>  81
<212>  PRT
<213>  Dengue virus type 3

<400>  15

Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Leu Asn 
1               5                   10                  15      


Ser Leu Gly Lys Met Val His Gln Ile Phe Gly Ser Ala Tyr Thr Ala 
            20                  25                  30          


Leu Phe Ser Gly Val Ser Trp Ile Met Lys Ile Gly Ile Gly Val Leu 
        35                  40                  45              


Leu Thr Trp Ile Gly Leu Asn Ser Lys Asn Thr Ser Met Ser Phe Ser 
    50                  55                  60                  


Cys Ile Ala Ile Gly Ile Ile Thr Leu Tyr Leu Gly Val Val Val Gln 
65                  70                  75                  80  


Ala 
    


<210>  16
<211>  81
<212>  PRT
<213>  Dengue virus type 4

<400>  16

Leu Gly Glu Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Leu Phe Thr 
1               5                   10                  15      


Ser Leu Gly Lys Ala Val His Gln Val Phe Gly Ser Val Tyr Thr Thr 
            20                  25                  30          


Met Phe Gly Gly Val Ser Trp Met Ile Arg Ile Leu Ile Gly Phe Leu 
        35                  40                  45              


Val Leu Trp Ile Gly Thr Asn Ser Arg Asn Thr Ser Met Ala Met Thr 
    50                  55                  60                  


Cys Ile Ala Val Gly Gly Ile Thr Leu Phe Leu Gly Phe Thr Val Gln 
65                  70                  75                  80  


Ala 
    


<210>  17
<211>  81
<212>  PRT
<213>  West Nile virus

<400>  17

Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Phe Thr 
1               5                   10                  15      


Ser Val Gly Lys Ala Val His Gln Val Phe Gly Gly Ala Phe Arg Ser 
            20                  25                  30          


Leu Phe Gly Gly Met Ser Trp Ile Thr Gln Gly Leu Leu Gly Ala Leu 
        35                  40                  45              


Leu Leu Trp Met Gly Ile Asn Ala Arg Asp Arg Ser Ile Ala Leu Thr 
    50                  55                  60                  


Phe Leu Ala Val Gly Gly Val Leu Leu Phe Leu Ser Val Asn Val His 
65                  70                  75                  80  


Ala 
    


<210>  18
<211>  81
<212>  PRT
<213>  Japanese encephalitis virus

<400>  18

Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Asn 
1               5                   10                  15      


Ser Ile Gly Lys Ala Val His Gln Val Phe Gly Gly Ala Phe Arg Thr 
            20                  25                  30          


Leu Phe Gly Gly Met Ser Trp Ile Thr Gln Gly Leu Met Gly Ala Leu 
        35                  40                  45              


Leu Leu Trp Met Gly Val Asn Ala Arg Asp Arg Ser Ile Ala Leu Ala 
    50                  55                  60                  


Phe Leu Ala Thr Gly Gly Val Leu Val Phe Leu Ala Thr Asn Val His 
65                  70                  75                  80  


Ala 
    


<210>  19
<211>  81
<212>  PRT
<213>  Murray Valley encephalitis virus

<400>  19

Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Phe Asn 
1               5                   10                  15      


Ser Ile Gly Lys Ala Val His Gln Val Phe Gly Gly Ala Phe Arg Thr 
            20                  25                  30          


Leu Phe Gly Gly Met Ser Trp Ile Ser Pro Gly Leu Leu Gly Ala Leu 
        35                  40                  45              


Leu Leu Trp Met Gly Val Asn Ala Arg Asp Lys Ser Ile Ala Leu Ala 
    50                  55                  60                  


Phe Leu Ala Thr Gly Gly Val Leu Leu Phe Leu Ala Thr Asn Val His 
65                  70                  75                  80  


Ala 
    


<210>  20
<211>  81
<212>  PRT
<213>  St. Louis encephalitis virus

<400>  20

Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Asn 
1               5                   10                  15      


Ser Ile Gly Lys Ala Val His Gln Val Phe Gly Gly Ala Phe Arg Thr 
            20                  25                  30          


Leu Phe Gly Gly Met Ser Trp Ile Thr Gln Gly Leu Leu Gly Ala Leu 
        35                  40                  45              


Leu Leu Trp Met Gly Leu Gln Ala Arg Asp Arg Ser Ile Ser Leu Thr 
    50                  55                  60                  


Leu Leu Ala Thr Gly Gly Ile Leu Ile Phe Leu Ala Thr Ser Val Gln 
65                  70                  75                  80  


Ala 
    


<210>  21
<211>  81
<212>  PRT
<213>  Yellow fever virus

<400>  21

Met Gly Asp Ala Ala Trp Asp Phe Ser Ser Ala Gly Gly Phe Phe Thr 
1               5                   10                  15      


Ser Val Gly Lys Gly Ile His Thr Val Phe Gly Ser Ala Phe Gln Gly 
            20                  25                  30          


Leu Phe Gly Gly Leu Asn Trp Ile Thr Lys Val Ile Met Gly Ala Val 
        35                  40                  45              


Leu Ile Trp Val Gly Ile Asn Thr Arg Asn Met Thr Met Ser Met Ser 
    50                  55                  60                  


Met Ile Leu Val Gly Val Ile Met Met Phe Leu Ser Leu Gly Val Gly 
65                  70                  75                  80  


Ala 
    


<210>  22
<211>  81
<212>  PRT
<213>  Tick-borne encephalitis virus

<400>  22

Ile Gly Glu His Ala Trp Asp Phe Gly Ser Ala Gly Gly Phe Leu Ser 
1               5                   10                  15      


Ser Ile Gly Lys Ala Val His Thr Val Leu Gly Gly Ala Phe Asn Ser 
            20                  25                  30          


Ile Phe Gly Gly Val Gly Phe Leu Pro Lys Leu Leu Leu Gly Val Ala 
        35                  40                  45              


Leu Ala Trp Leu Gly Leu Asn Met Arg Asn Pro Thr Met Ser Met Ser 
    50                  55                  60                  


Phe Leu Leu Ala Gly Gly Leu Val Leu Ala Met Thr Leu Gly Val Gly 
65                  70                  75                  80  


Ala 
    


<210>  23
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Leu Gly Gly Val Phe Thr 
1               5                   10                  15      


Ser Ile Gly Lys Ala Leu His Gln Val Phe Gly Ala Ile Tyr Gly Ala 
            20                  25                  30          


Ala Phe Ser Gly Val Ser Trp Thr Met Lys Ile Leu Ile Gly Val Ile 
        35                  40                  45              


Ile Thr Trp Ile Gly Ile Asn Ser Arg Ser Thr Ser Leu Ser Val Thr 
    50                  55                  60                  


Leu Val Leu Val Gly Val Val Thr Leu Tyr Leu Gly Ala Met Val Gln 
65                  70                  75                  80  


Ala 
    


<210>  24
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Thr 
1               5                   10                  15      


Ser Val Gly Lys Leu Ile His Gln Ile Phe Gly Thr Ala Tyr Gly Val 
            20                  25                  30          


Leu Phe Ser Gly Val Ser Trp Thr Met Lys Ile Gly Ile Gly Ile Leu 
        35                  40                  45              


Leu Thr Trp Leu Gly Ile Asn Ser Arg Ser Thr Ser Leu Ser Met Thr 
    50                  55                  60                  


Cys Ile Ala Val Gly Met Val Thr Leu Tyr Leu Gly Val Met Val Gln 
65                  70                  75                  80  


Ala 
    


<210>  25
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Leu Asn 
1               5                   10                  15      


Ser Leu Gly Lys Met Val His Gln Ile Phe Gly Ser Ala Tyr Thr Ala 
            20                  25                  30          


Leu Phe Ser Gly Val Ser Trp Ile Met Lys Ile Gly Ile Gly Val Leu 
        35                  40                  45              


Leu Thr Trp Ile Gly Ile Asn Ser Lys Asn Thr Ser Met Ser Phe Thr 
    50                  55                  60                  


Cys Ile Ala Val Gly Ile Ile Thr Leu Tyr Leu Gly Val Val Val Gln 
65                  70                  75                  80  


Ala 
    


<210>  26
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Leu Gly Glu Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Leu Phe Thr 
1               5                   10                  15      


Ser Leu Gly Lys Ala Val His Gln Val Phe Gly Ser Val Tyr Thr Thr 
            20                  25                  30          


Met Phe Gly Gly Val Ser Trp Met Ile Arg Ile Leu Ile Gly Phe Leu 
        35                  40                  45              


Val Leu Trp Ile Gly Ile Asn Ser Arg Asn Thr Ser Met Ala Met Thr 
    50                  55                  60                  


Cys Ile Ala Val Gly Gly Ile Thr Leu Phe Leu Gly Phe Thr Val Gln 
65                  70                  75                  80  


Ala 
    


<210>  27
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Asn 
1               5                   10                  15      


Ser Ile Gly Lys Ala Val His Gln Val Phe Gly Gly Ala Phe Arg Thr 
            20                  25                  30          


Leu Phe Gly Gly Met Ser Trp Ile Thr Gln Gly Leu Met Gly Ala Leu 
        35                  40                  45              


Leu Leu Trp Met Gly Ile Asn Ala Arg Asp Arg Ser Ile Ala Leu Thr 
    50                  55                  60                  


Phe Leu Ala Val Gly Gly Val Leu Leu Phe Leu Ala Thr Asn Val His 
65                  70                  75                  80  


Ala 
    


<210>  28
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Phe Asn 
1               5                   10                  15      


Ser Ile Gly Lys Ala Val His Gln Val Phe Gly Gly Ala Phe Arg Thr 
            20                  25                  30          


Leu Phe Gly Gly Met Ser Trp Ile Ser Pro Gly Leu Leu Gly Ala Leu 
        35                  40                  45              


Leu Leu Trp Met Gly Ile Asn Ala Arg Asp Lys Ser Ile Ala Leu Thr 
    50                  55                  60                  


Phe Leu Ala Val Gly Gly Val Leu Leu Phe Leu Ala Thr Asn Val His 
65                  70                  75                  80  


Ala 
    


<210>  29
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Ile Gly Gly Val Phe Asn 
1               5                   10                  15      


Ser Ile Gly Lys Ala Val His Gln Val Phe Gly Gly Ala Phe Arg Thr 
            20                  25                  30          


Leu Phe Gly Gly Met Ser Trp Ile Thr Gln Gly Leu Leu Gly Ala Leu 
        35                  40                  45              


Leu Leu Trp Met Gly Ile Gln Ala Arg Asp Arg Ser Ile Ser Leu Thr 
    50                  55                  60                  


Leu Leu Ala Val Gly Gly Ile Leu Leu Phe Leu Ala Thr Ser Val Gln 
65                  70                  75                  80  


Ala 
    


<210>  30
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Met Gly Asp Ala Ala Trp Asp Phe Ser Ser Ala Gly Gly Phe Phe Thr 
1               5                   10                  15      


Ser Val Gly Lys Gly Ile His Thr Val Phe Gly Ser Ala Phe Gln Gly 
            20                  25                  30          


Leu Phe Gly Gly Leu Asn Trp Ile Thr Lys Val Ile Met Gly Ala Val 
        35                  40                  45              


Leu Ile Trp Val Gly Ile Asn Thr Arg Asn Met Thr Met Ser Met Thr 
    50                  55                  60                  


Met Ile Leu Val Gly Val Ile Met Leu Phe Leu Ser Leu Gly Val Gly 
65                  70                  75                  80  


Ala 
    


<210>  31
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Ile Gly Glu His Ala Trp Asp Phe Gly Ser Ala Gly Gly Phe Leu Ser 
1               5                   10                  15      


Ser Ile Gly Lys Ala Val His Thr Val Leu Gly Gly Ala Phe Asn Ser 
            20                  25                  30          


Ile Phe Gly Gly Val Gly Phe Leu Pro Lys Leu Leu Leu Gly Val Ala 
        35                  40                  45              


Leu Ala Trp Leu Gly Ile Asn Met Arg Asn Pro Thr Met Ser Met Thr 
    50                  55                  60                  


Phe Leu Leu Val Gly Gly Leu Val Leu Ala Met Thr Leu Gly Val Gly 
65                  70                  75                  80  


Ala 
    


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Thr Gln Gly Leu Leu Gly Ala Leu Leu Leu Trp Met Gly Ile Asn 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Gln Gly Leu Met Gly Ala Leu Leu Leu Trp Met Gly Val Asn Ala 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Gly Ala Leu Leu Leu Trp Met Gly Ile Asn Ala Arg Asp Arg Ser 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Ala Leu Leu Leu Trp Met Gly Val Asn Ala Arg Asp Arg Ser Ile 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Trp Met Gly Ile Asn Ala Arg Asp Arg Ser Ile Ala Leu Thr Phe 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Met Gly Val Asn Ala Arg Asp Arg Ser Ile Ala Leu Ala Phe Leu 
1               5                   10                  15  


<210>  38
<211>  501
<212>  PRT
<213>  West Nile virus

<400>  38

Phe Asn Cys Leu Gly Met Ser Asn Arg Asp Phe Leu Glu Gly Val Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Leu Val Leu Glu Gly Asp Ser Cys Val Thr 
            20                  25                  30          


Ile Met Ser Lys Asp Lys Pro Thr Ile Asp Val Lys Met Met Asn Met 
        35                  40                  45              


Glu Ala Ala Asn Leu Ala Glu Val Arg Ser Tyr Cys Tyr Leu Ala Thr 
    50                  55                  60                  


Val Ser Asp Leu Ser Thr Lys Ala Ala Cys Pro Thr Met Gly Glu Ala 
65                  70                  75                  80  


His Asn Asp Lys Arg Ala Asp Pro Ala Phe Val Cys Arg Gln Gly Val 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Ile Asp Thr Cys Ala Lys Phe Ala Cys Ser Thr Lys Ala Ile Gly Arg 
        115                 120                 125             


Thr Ile Leu Lys Glu Asn Ile Lys Tyr Glu Val Ala Ile Phe Val His 
    130                 135                 140                 


Gly Pro Thr Thr Val Glu Ser His Gly Asn Tyr Ser Thr Gln Val Gly 
145                 150                 155                 160 


Ala Thr Gln Ala Gly Arg Phe Ser Ile Thr Pro Ala Ala Pro Ser Tyr 
                165                 170                 175     


Thr Leu Lys Leu Gly Glu Tyr Gly Glu Val Thr Val Asp Cys Glu Pro 
            180                 185                 190         


Arg Ser Gly Ile Asp Thr Asn Ala Tyr Tyr Val Met Thr Val Gly Thr 
        195                 200                 205             


Lys Thr Phe Leu Val His Arg Glu Trp Phe Met Asp Leu Asn Leu Pro 
    210                 215                 220                 


Trp Ser Ser Ala Gly Ser Thr Val Trp Arg Asn Arg Glu Thr Leu Met 
225                 230                 235                 240 


Glu Phe Glu Glu Pro His Ala Thr Lys Gln Ser Val Ile Ala Leu Gly 
                245                 250                 255     


Ser Gln Glu Gly Ala Leu His Gln Ala Leu Ala Gly Ala Ile Pro Val 
            260                 265                 270         


Glu Phe Ser Ser Asn Thr Val Lys Leu Thr Ser Gly His Leu Lys Cys 
        275                 280                 285             


Arg Val Lys Met Glu Lys Leu Gln Leu Lys Gly Thr Thr Tyr Gly Val 
    290                 295                 300                 


Cys Ser Lys Ala Phe Lys Phe Leu Gly Thr Pro Ala Asp Thr Gly His 
305                 310                 315                 320 


Gly Thr Val Val Leu Glu Leu Gln Tyr Thr Gly Thr Asp Gly Pro Cys 
                325                 330                 335     


Lys Val Pro Ile Ser Ser Val Ala Ser Leu Asn Asp Leu Thr Pro Val 
            340                 345                 350         


Gly Arg Leu Val Thr Val Asn Pro Phe Val Ser Val Ala Thr Ala Asn 
        355                 360                 365             


Ala Lys Val Leu Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    370                 375                 380                 


Val Val Gly Arg Gly Glu Gln Gln Ile Asn His His Trp His Lys Ser 
385                 390                 395                 400 


Gly Ser Ser Ile Gly Lys Ala Phe Thr Thr Thr Leu Lys Gly Ala Gln 
                405                 410                 415     


Arg Leu Ala Ala Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly 
            420                 425                 430         


Gly Val Phe Thr Ser Val Gly Lys Ala Val His Gln Val Phe Gly Gly 
        435                 440                 445             


Ala Phe Arg Ser Leu Phe Gly Gly Met Ser Trp Ile Thr Gln Gly Leu 
    450                 455                 460                 


Leu Gly Ala Leu Leu Leu Trp Met Gly Ile Asn Ala Arg Asp Arg Ser 
465                 470                 475                 480 


Ile Ala Leu Thr Phe Leu Ala Val Gly Gly Val Leu Leu Phe Leu Ser 
                485                 490                 495     


Val Asn Val His Ala 
            500     


