                         SEQUENCE LISTING

<110>  Pfizer Inc.
       Bammert, Gary F.
       Dunham, Steven A.
 
<120>  INTERLEUKIN-31 MONOCLONAL ANTIBODY

<130>  PC71750

<150>  61/510,268
<151>  2011-07-21

<160>  78    

<170>  PatentIn version 3.4

<210>  1
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  1

Tyr Tyr Asp Ile Asn 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  2

Ser Tyr Asp Met Ser 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  3

Asn Tyr Gly Met Ser 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  4

Trp Ile Phe Pro Gly Asp Gly Gly Thr Lys Tyr Asn Glu Thr Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  5

Thr Ile Thr Ser Gly Gly Gly Tyr Thr Tyr Ser Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  6

Thr Ile Ser Tyr Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn Ile Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  7

Ala Arg Gly Gly Thr Ser Val Ile Arg Asp Ala Met Asp Tyr 
1               5                   10                  


<210>  8
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  8

Ala Arg Gln Asn Trp Val Val Gly Leu Ala Tyr 
1               5                   10      


<210>  9
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  9

Val Arg Gly Tyr Gly Tyr Asp Thr Met Asp Tyr 
1               5                   10      


<210>  10
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  10

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met His 
1               5                   10                  15  


<210>  11
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  11

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  12
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  12

Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr Gly Leu Met His 
1               5                   10                  15  


<210>  13
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  13

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  14

Gly Ala Ser Thr Arg Glu Ser 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  15

Arg Ala Ser Asn Leu Glu Ala 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  16

Gln Gln Ser Asn Lys Asp Pro Leu Thr 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  17

Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  18

Gln Gln Ser Arg Glu Tyr Pro Trp Thr 
1               5                   


<210>  19
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  19

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Thr Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Lys Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  20
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  caninized variable light chain mAb sequence, from Mus musculus 
       and Canis

<400>  20

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Lys Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  21
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  caninized variable light chain mAb sequence, from Mus musculus 
       and Canis

<400>  21

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Lys Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  22
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  22

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Asp Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Trp Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  23
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  caninized variable light chain mAb sequence, from Mus musculus 
       and Canis

<400>  23

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  24
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  24

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Gly Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Gln Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  25
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  caninized variable light chain mAb sequence, from Mus musculus 
       and Canis

<400>  25

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Gly Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  26
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  26

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Lys Tyr Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Gly Thr Lys Tyr Asn Glu Thr Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Ser Val Ile Arg Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  27
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  caninized variable heavy chain mAb sequence, from Mus musculus 
       and Canis

<400>  27

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Lys Tyr Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Gly Gly Thr Lys Tyr Asn Glu Thr Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Ser Val Ile Arg Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  28
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  28

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ile Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Gly Tyr Thr Tyr Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Asn Trp Val Val Gly Leu Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  29
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  caninized variable heavy chain mAb sequence, from Mus musculus 
       and Canis

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Gly Tyr Thr Tyr Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Asn Trp Val Val Gly Leu Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  30
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Tyr Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Gly Tyr Asp Thr Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  31
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  caninized variable heavy chain mAb sequence, from Mus musculus 
       and Canis

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Tyr Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Gly Tyr Asp Thr Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  32
<211>  159
<212>  PRT
<213>  Canis familiaris

<400>  32

Met Leu Ser His Thr Gly Pro Ser Arg Phe Ala Leu Phe Leu Leu Cys 
1               5                   10                  15      


Ser Met Glu Thr Leu Leu Ser Ser His Met Ala Pro Thr His Gln Leu 
            20                  25                  30          


Pro Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser 
        35                  40                  45              


Arg Gly Leu Leu Glu Asp Tyr Gln Lys Lys Glu Thr Gly Val Pro Glu 
    50                  55                  60                  


Ser Asn Arg Thr Leu Leu Leu Cys Leu Thr Ser Asp Ser Gln Pro Pro 
65                  70                  75                  80  


Arg Leu Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 
                85                  90                  95      


Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 
            100                 105                 110         


Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp 
        115                 120                 125             


Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
    130                 135                 140                 


Ala Cys Leu Glu Ser Val Phe Lys Ser Leu Asn Ser Gly Pro Gln 
145                 150                 155                 


<210>  33
<211>  477
<212>  DNA
<213>  Canis familiaris

<400>  33
atgctctccc acacaggacc atccaggttt gccctgttcc tgctctgctc tatggaaacc     60

ttgctgtcct cccatatggc acccacccat cagctaccac caagtgatgt acgaaaaatc    120

atcttggaat tacagccctt gtcgagggga cttttggaag actatcagaa gaaagagaca    180

ggggtgccag aatccaaccg taccttgctg ctgtgtctca cctctgattc ccaaccacca    240

cgcctcaaca gctcagccat cttgccttat ttcagggcaa tcagaccatt atcagataag    300

aacattattg ataaaatcat agaacagctt gacaaactca aatttcaaca tgaaccagaa    360

acagaaattt ctgtgcctgc agatactttt gaatgtaaaa gcttcatctt gacgatttta    420

cagcagttct cggcgtgcct ggaaagtgtg tttaagtcac taaactctgg acctcag       477


<210>  34
<211>  333
<212>  DNA
<213>  Mus musculus

<400>  34
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc     60

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gcactggtac    120

cagcagaaac caggacagcc acccaaactc ctcatctatc gtgcatccaa cctagaatct    180

gggatccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattaat    240

cctgtggaga ctgatgatgt tgcaacctat tactgtcagc aaagtaataa ggatccgctc    300

acgttcggtg ctgggaccaa gctggagctg aaa                                 333


<210>  35
<211>  363
<212>  DNA
<213>  Mus musculus

<400>  35
caggttcagc tgcagcagtc tggagctgaa ctggtaaagc ctggggcttc agtgaagttg     60

tcctgcaagg cttctggcta caccttcaaa tactatgata taaactgggt gaggcagagg    120

cctgaacagg gacttgagtg gattggatgg atttttcctg gagatggtgg tactaagtac    180

aatgagacgt tcaagggcaa ggccacactg actacagaca aatcctccag cacagcctac    240

atgcagctca gcaggctgac atctgaggac tctgctgtct atttctgtgc aagagggggg    300

acttcggtga taagggatgc tatggactac tggggtcaag gaacctcagt caccgtctcc    360

tca                                                                  363


<210>  36
<211>  339
<212>  DNA
<213>  Mus musculus

<400>  36
gacattgtga tgtcacagtc tccatcctcc ctgagtgtgt cagcaggaga taaggtcact     60

atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctacttggcc    120

tggtaccagc agaaaccatg gcagcctcct aaactgctga tctacggggc atccactagg    180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc    240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga ttatagttat    300

ccgtacacgt tcggaggggg gaccaagctg gaaataaaa                           339


<210>  37
<211>  354
<212>  DNA
<213>  Mus musculus

<400>  37
gaagtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc     60

tcctgtgcag cctctggatt cgctttcagc agctatgaca tgtcttgggt tcgccagatt    120

ccggaaaaga ggctggagtg ggtcgcaacc attactagtg gtggtggtta cacctactct    180

gcagacagtg tgaagggccg attcaccatc tccagagaca atgccaggaa caccctgtac    240

ctgcaaatga gcagtctgag gtctgaggac acggccgtgt attattgtgc aagacaaaac    300

tgggtcgtgg ggttagctta ttggggccaa gggactctgg tcactgtctc tgca          354


<210>  38
<211>  333
<212>  DNA
<213>  Mus musculus

<400>  38
gacattttgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccatc     60

atctcctgca aggccagcca aagtgtcagt tttgctggta ctggtttaat gcactggtac    120

caacagaaac caggacagca acccaaactc ctcatctatc gtgcatccaa cctagaagct    180

ggggttccta ccaggtttag tggcagtggg tctaggacag acttcaccct caatatccat    240

cctgtggagg aggaggatgc tgcaacctat ttctgtcagc aaagcaggga atatccgtgg    300

acgttcggtg gaggcaccaa gctggaaatc aaa                                 333


<210>  39
<211>  353
<212>  DNA
<213>  Mus musculus

<400>  39
gaggtgcagt tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc     60

tcctgtgcag cctctggatt ctctttcagt aactatggca tgtcttgggt tcgccagact    120

ccagacaaga ggctggagtg ggtcgcaacc attagttatg gtggtagtta cacctactat    180

ccagacaata taaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac    240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgt aagggggtat    300

ggttacgata ctatggacta ctggggtcaa ggaacctcag tcaccgtctc gag           353


<210>  40
<211>  331
<212>  PRT
<213>  Canis familiaris

<400>  40

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu His Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Val His Pro Ala Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Phe Asn Glu Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro Val 
            100                 105                 110         


Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro Lys Pro 
        115                 120                 125             


Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val 
    130                 135                 140                 


Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
145                 150                 155                 160 


Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu Gln Gln 
                165                 170                 175     


Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu His Gln 
            180                 185                 190         


Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His Ile Asp 
        195                 200                 205             


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Arg Ala 
    210                 215                 220                 


His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser 
225                 230                 235                 240 


Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr Pro 
                245                 250                 255     


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
            260                 265                 270         


Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly 
    290                 295                 300                 


Asp Pro Phe Thr Cys Ala Val Met His Glu Thr Leu Gln Asn His Tyr 
305                 310                 315                 320 


Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330     


<210>  41
<211>  993
<212>  DNA
<213>  Canis familiaris

<400>  41
gcctccacca cggcgccctc ggttttccca ctggccccca gctgcgggtc cacttccggc     60

tccacggtgg ccctggcctg cctggtgtca ggctacttcc ccgagcctgt aactgtgtcc    120

tggaactccg gctccttgac cagcggtgtg cacaccttcc cgtccgtcct gcagtcctca    180

gggcttcact ccctcagcag catggtgaca gtgccctcca gcaggtggcc cagcgagacc    240

ttcacctgca acgtggtcca cccagccagc aacactaaag tagacaagcc agtgttcaat    300

gaatgcagat gcactgatac acccccatgc ccagtccctg aacctctggg agggccttcg    360

gtcctcatct ttcccccgaa acccaaggac atcctcagga ttacccgaac acccgaggtc    420

acctgtgtgg tgttagatct gggccgtgag gaccctgagg tgcagatcag ctggttcgtg    480

gatggtaagg aggtgcacac agccaagacc cagtctcgtg agcagcagtt caacggcacc    540

taccgtgtgg tcagcgtcct ccccattgag caccaggact ggctcacagg gaaggagttc    600

aagtgcagag tcaaccacat agacctcccg tctcccatcg agaggaccat ctctaaggcc    660

agagggaggg cccataagcc cagtgtgtat gtcctgccgc catccccaaa ggagttgtca    720

tccagtgaca cagtcagcat cacctgcctg ataaaagact tctacccacc tgacattgat    780

gtggagtggc agagcaatgg acagcaggag cccgagagga agcaccgcat gaccccgccc    840

cagctggacg aggacgggtc ctacttcctg tacagcaagc tctctgtgga caagagccgc    900

tggcagcagg gagacccctt cacatgtgcg gtgatgcatg aaactctaca gaaccactac    960

acagatctat ccctctccca ttctccgggt aaa                                 993


<210>  42
<211>  335
<212>  PRT
<213>  Canis familiaris

<400>  42

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln 
145                 150                 155                 160 


Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys 
        195                 200                 205             


Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser 
225                 230                 235                 240 


Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys 
                245                 250                 255     


Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln 
            260                 265                 270         


Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu 
        275                 280                 285             


Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg 
    290                 295                 300                 


Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu 
305                 310                 315                 320 


His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335 


<210>  43
<211>  1005
<212>  DNA
<213>  Canis familiaris

<400>  43
gcctcaacaa ctgctcctag cgtgtttccc ctggccccta gctgcggaag tacctcaggc     60

agcacagtgg ccctggcttg tctggtgtct ggatatttcc ctgagccagt gaccgtgagt    120

tggaacagcg gctctctgac ctccggggtg cacacatttc catctgtgct gcagtctagt    180

ggcctgtact ccctgtcaag catggtgact gtgccttcct ctaggtggcc atcagaaact    240

ttcacctgca acgtggccca tcccgccagc aagaccaaag tggacaagcc cgtgcctaaa    300

agggagaatg gaagggtgcc aagaccacct gattgcccta agtgtccagc tccagaaatg    360

ctgggaggac caagcgtgtt catctttcca cccaagccca aagacacact gctgattgct    420

agaactcccg aggtgacctg cgtggtggtg gacctggatc cagaggaccc cgaagtgcag    480

atctcctggt tcgtggatgg gaagcagatg cagacagcca aaactcagcc tcgggaggaa    540

cagtttaacg gaacctatag agtggtgtct gtgctgccaa ttggacacca ggactggctg    600

aagggcaaac agtttacatg caaggtgaac aacaaggccc tgcctagtcc aatcgagagg    660

actatttcaa aagctagggg acaggctcat cagccttccg tgtatgtgct gcctccatcc    720

cgggaggaac tgtctaagaa cacagtgagt ctgacttgtc tgatcaaaga tttctttccc    780

cctgacattg atgtggagtg gcagagcaat gggcagcagg agccagaatc caagtacaga    840

accacaccac cccagctgga cgaagatggc tcctatttcc tgtacagtaa gctgtcagtg    900

gacaaatcta ggtggcagcg cggggatacc tttatctgcg ccgtgatgca cgaggctctg    960

cacaatcatt acacacaaga aagtctgtca catagccccg gcaag                   1005


<210>  44
<211>  106
<212>  PRT
<213>  Canis familiaris

<400>  44

Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp 
1               5                   10                  15      


Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln 
        35                  40                  45              


Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser 
65                  70                  75                  80  


His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr 
                85                  90                  95      


Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys 
            100                 105     


<210>  45
<211>  318
<212>  DNA
<213>  Canis familiaris

<400>  45
aggaacgacg cccagcctgc tgtgtatctg tttcagccct cccctgatca gctgcacact     60

ggctctgcta gtgtggtgtg tctgctgaac agcttctacc caaaggatat caatgtgaag    120

tggaaagtgg acggcgtgat ccaggatact gggattcagg agtccgtgac cgaacaggac    180

aaagattcaa catatagcct gagctccact ctgaccatgt ctagtaccga gtacctgagc    240

cacgaactgt attcctgcga gatcactcat aagtccctgc cctctaccct gatcaagagc    300

ttccagagat cagagtgt                                                  318


<210>  46
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a caninized variable light chain mAb
       sequence, from Mus musculus and Canis

<400>  46
gagatcgtga tgacccagag ccccgccagc ctgagcctga gccaggaaga gaaagtcacc     60

atcacatgca agagcagcca gagcctgctg aacagcggca accagaagaa ctacctggcc    120

tggtatcagc agaagcccgg ccaggccccc aagctgctga tctacggcgc cagcacccgc    180

gagagcggcg tgccaagcag attttccggc agcggctccg gcaccgactt cagcttcacc    240

atcagcagcc tggaacccga ggacgtggcc gtgtactact gccagaacga ctacagctac    300

ccctacacct tcggccaggg taccaagctg gagatcaag                           339


<210>  47
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a caninized variable heavy chain mAb
       sequence, from Mus musculus and Canis

<400>  47
gaggtgcagc tggtggaatc tggcggcgac ctggtcaagc ctggcggcag cctgagactg     60

agctgtgtgg ccagcggctt caccttcagc agctacgaca tgagctgggt ccgacaggcc    120

cctggcaagg gactgcagtg ggtggccacc atcaccagcg gcggaggcta cacctacagc    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgcccggaa caccctgtac    240

ctgcagatga acagcctgcg gagcgaggac accgccgtgt actactgcgc cagacagaac    300

tgggtcgtgg gcctggccta ctggggccag ggaacactcg tgaccgtctc gagc          354


<210>  48
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a caninized variable light chain mAb
       sequence, from Mus musculus and Canis

<400>  48
gagatcgtga tgacccagag ccccgccagc ctgagcctga gccaggaaga gaaagtcacc     60

atcacatgca aggccagcca gagcgtgtcc ttcgccggca caggcctgat gcactggtat    120

cagcagaagc ccggccaggc ccccaagctg ctgatctacc gggccagcaa cctggaagcc    180

ggcgtgccaa gcagattcag cggcagcggc tccggcaccg acttcagctt caccatcagc    240

agcctcgaac ccgaggacgt ggccgtgtac tactgccagc agagcagaga gtacccctgg    300

accttcggcc agggtaccaa gctggagatc aag                                 333


<210>  49
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a caninized variable heavy chain mAb
       sequence, from Mus musculus and Canis

<400>  49
gaggtgcagc tggtggaatc tggcggcgac ctggtcaagc ctggcggcag cctgagactg     60

agctgtgtgg ccagcggctt caccttcagc aactacggca tgagctgggt ccgacaggcc    120

cctggcaagg gactgcagtg ggtggccacc atcagctacg gcggcagcta cacctactac    180

cccgacaaca tcaagggccg gttcaccatc agccgggaca acgccaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccatgt actactgcgt gcggggctac    300

ggctacgaca caatggacta ctggggccag ggcaccctcg tgaccgtctc gagc          354


<210>  50
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a caninized variable light chain mAb
       sequence, from Mus musculus and Canis

<400>  50
gatatagtga tgacacaaac tcctctcagt ctttccgtat caccgggaga accggcttcc     60

atttcctgtc gggcctcaga gtctgtggac aactacggga tatccttcat gcactggtat    120

cagcagaaac ccggccagcc ccctaaactc cttatttaca gggccagtaa tctggaaagc    180

ggtgtgcccg atcgatttag cggttccggg agcggcacag atttcaccct gcgaatctct    240

agagttgaag cggatgatgc aggagtatat tactgccagc aatccaataa ggatcccctt    300

acattcggcg cgggtaccaa gctggagatc aag                                 333


<210>  51
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a caninized variable heavy chain mAb
       sequence, from Mus musculus and Canis

<400>  51
gaggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgccag cgtgaaggtg     60

tcctgcaaga ccagcggcta caccttcaag tactacgaca tcaactgggt ccgacaggcc    120

cctggcgccg gactggattg gatgggctgg atcttccccg gcgacggcgg caccaagtac    180

aacgagacat tcaagggcag agtgaccctg accgccgaca ccagcaccag caccgcctac    240

atggaactga gcagcctgag agccggcgat atcgctgtgt actactgcgc cagaggcggc    300

accagcgtga tccgggacgc tatggactac tggggccagg gcaccctcgt gaccgtctcg    360

agc                                                                  363


<210>  52
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a caninized variable light chain mAb
       sequence, from Mus musculus and Canis

<400>  52
gacattgtta tgactcagac gcccctgagc ctgagcgtct cccccggcga gcccgctagt     60

attagttgcc gggcatccga gtcagtggac aattatggca tcagctttat gcattggttt    120

cagcagaaac caggtcagtc ccctcaactc ctgatttaca gagcttccaa tctggaatca    180

ggcgttcctg acagatttag cggatcaggc tccgggacag atttcaccct gcgcatcagt    240

cgcgtggaag ccgatgacgc aggcgtctat tattgtcaac agtccaacaa ggatcccctt    300

acattcggag ccggtaccaa gctggagatc aag                                 333


<210>  53
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  caninized variable light chain mAb sequence, from Mus musculus 
       and Canis

<400>  53

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Arg Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Lys Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  54
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a caninized variable light chain mAb
       sequence, from Mus musculus and Canis

<400>  54
gacatcgtga tgacccagac ccccctgagc ctgagcgtgt cccctggcga gcctgccagc     60

atcagctgca gagccagcga gagcgtggac aactacggca tcagcttcat gcactggttc    120

cagcagaagc ccggccagag cccccagcgg ctgatctaca gagccagcaa cctggaaagc    180

ggcgtgcccg atcggtttag cggctctggc agcggcaccg acttcaccct gcggatctct    240

cgggtggaag ccgatgacgc cggagtgtac tactgccagc agagcaacaa ggaccccctg    300

acctttggcg ccggtaccaa gctggagatc aag                                 333


<210>  55
<211>  148
<212>  PRT
<213>  Artificial

<220>
<223>  canine IL-31 full length protein encoded by codon-optimized 
       nucleotide sequence

<400>  55

Met Arg Gly Ser His His His His His His Gly Ser Ser His Met Ala 
1               5                   10                  15      


Pro Thr His Gln Leu Pro Pro Ser Asp Val Arg Lys Ile Ile Leu Glu 
            20                  25                  30          


Leu Gln Pro Leu Ser Arg Gly Leu Leu Glu Asp Tyr Gln Lys Lys Glu 
        35                  40                  45              


Thr Gly Val Pro Glu Ser Asn Arg Thr Leu Leu Leu Cys Leu Thr Ser 
    50                  55                  60                  


Asp Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala Ile Leu Pro Tyr Phe 
65                  70                  75                  80  


Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile 
                85                  90                  95      


Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile 
            100                 105                 110         


Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile 
        115                 120                 125             


Leu Gln Gln Phe Ser Ala Cys Leu Glu Ser Val Phe Lys Ser Leu Asn 
    130                 135                 140                 


Ser Gly Pro Gln 
145             


<210>  56
<211>  444
<212>  DNA
<213>  Artificial

<220>
<223>  codon-optimized nucleotide sequence encoding canine IL-31 
       full-length protein

<400>  56
atgagaggat cccatcacca tcaccaccac ggctcatctc atatggctcc tactcaccaa     60

ttaccaccct ccgatgtccg taaaattatt ctcgaattac aacctttatc ccgcggtctg    120

ctcgaagatt accaaaaaaa agaaacaggc gtcccagaaa gcaaccgtac attactcctt    180

tgccttacct ccgattccca accacctcgt cttaactcat cagccattct cccttatttc    240

cgtgccattc gccctctttc tgataaaaat attattgaca aaattattga acaactcgac    300

aaattaaaat tccaacacga acccgaaacc gaaatctccg tacctgccga tacctttgaa    360

tgcaaatcct ttatcctcac tattttacaa caattctccg catgtctcga atccgtcttc    420

aaatctctca attccggtcc acag                                           444


<210>  57
<211>  151
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence corresponding to canine IL-31 protein with 
       N-terminal truncation (-20N)

<400>  57

Met Leu Glu Leu Gln Pro Leu Ser Arg Gly Leu Leu Glu Asp Tyr Gln 
1               5                   10                  15      


Lys Lys Glu Thr Gly Val Pro Glu Ser Asn Arg Thr Leu Leu Leu Cys 
            20                  25                  30          


Leu Thr Ser Asp Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala Ile Leu 
        35                  40                  45              


Pro Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp 
    50                  55                  60                  


Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu 
65                  70                  75                  80  


Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile 
                85                  90                  95      


Leu Thr Ile Leu Gln Gln Phe Ser Ala Cys Leu Glu Ser Val Phe Lys 
            100                 105                 110         


Ser Leu Asn Ser Gly Pro Gln Lys Gly Glu Leu Asn Ser Lys Leu Glu 
        115                 120                 125             


Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg Thr 
    130                 135                 140                 


Gly His His His His His His 
145                 150     


<210>  58
<211>  456
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding canine IL-31 protein with N-terminal
       truncation (-20N)

<400>  58
atgctcgaat tacaaccttt atcccgcggt ctgctcgaag attaccaaaa aaaagaaaca     60

ggcgtcccag aaagcaaccg tacattactc ctttgcctta cctccgattc ccaaccacct    120

cgtcttaact catcagccat tctcccttat ttccgtgcca ttcgccctct ttctgataaa    180

aatattattg acaaaattat tgaacaactc gacaaattaa aattccaaca cgaacccgaa    240

accgaaatct ccgtacctgc cgataccttt gaatgcaaat cctttatcct cactatttta    300

caacaattct ccgcatgtct cgaatccgtc ttcaaatctc tcaattccgg tccacagaag    360

ggcgagctca attcgaagct tgaaggtaag cctatcccta accctctcct cggtctcgat    420

tctacgcgta ccggtcatca tcaccatcac cattga                              456


<210>  59
<211>  131
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence corresponding to canine IL-31 protein with 
       N-terminal truncation (-40N)

<400>  59

Met Val Pro Glu Ser Asn Arg Thr Leu Leu Leu Cys Leu Thr Ser Asp 
1               5                   10                  15      


Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg 
            20                  25                  30          


Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu 
        35                  40                  45              


Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser 
    50                  55                  60                  


Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu 
65                  70                  75                  80  


Gln Gln Phe Ser Ala Cys Leu Glu Ser Val Phe Lys Ser Leu Asn Ser 
                85                  90                  95      


Gly Pro Gln Lys Gly Glu Leu Asn Ser Lys Leu Glu Gly Lys Pro Ile 
            100                 105                 110         


Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg Thr Gly His His His 
        115                 120                 125             


His His His 
    130     


<210>  60
<211>  393
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding canine IL-31 protein with N-terminal
       truncation (-40N)

<400>  60
atggtcccag aaagcaaccg tacattactc ctttgcctta cctccgattc ccaaccacct     60

cgtcttaact catcagccat tctcccttat ttccgtgcca ttcgccctct ttctgataaa    120

aatattattg acaaaattat tgaacaactc gacaaattaa aattccaaca cgaacccgaa    180

accgaaatct ccgtacctgc cgataccttt gaatgcaaat cctttatcct cactatttta    240

caacaattct ccgcatgtct cgaatccgtc ttcaaatctc tcaattccgg tccacagaag    300

ggcgagctca attcgaagct tgaaggtaag cctatcccta accctctcct cggtcwcgat    360

tctacgcgta ccggtcatca tcaccatcac cat                                 393


<210>  61
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence corresponding to canine IL-31 protein with 
       N-terminal truncation (-60N)

<400>  61

Met Leu Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 
1               5                   10                  15      


Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 
            20                  25                  30          


Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp 
        35                  40                  45              


Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
    50                  55                  60                  


Ala Cys Leu Glu Ser Val Phe Lys Ser Leu Asn Ser Gly Pro Gln Lys 
65                  70                  75                  80  


Gly Glu Leu Asn Ser Lys Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu 
                85                  90                  95      


Leu Gly Leu Asp Ser Thr Arg Thr Gly His His His His His His 
            100                 105                 110     


<210>  62
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding canine IL-31 protein with N-terminal
       truncation (-60N)

<400>  62
atgcttaact catcagccat tctcccttat ttccgtgcca ttcgccctct ttctgataaa     60

aatattattg acaaaattat tgaacaactc gacaaattaa aattccaaca cgaacccgaa    120

accgaaatct ccgtacctgc cgataccttt gaatgcaaat cctttatcct cactatttta    180

caacaattct ccgcatgtct cgaatccgtc ttcaaatctc tcaattccgg tccacagaag    240

ggcgagctca attcgaagct tgaaggtaag cctatcccta accctctcct cggtctcgat    300

tctacgcgta ccggtcatca tcaccatcac cat                                 333


<210>  63
<211>  136
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence corresponding to canine IL-31 protein with 
       C-terminal truncation at position 20-122

<400>  63

Met Leu Glu Leu Gln Pro Leu Ser Arg Gly Leu Leu Glu Asp Tyr Gln 
1               5                   10                  15      


Lys Lys Glu Thr Gly Val Pro Glu Ser Asn Arg Thr Leu Leu Leu Cys 
            20                  25                  30          


Leu Thr Ser Asp Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala Ile Leu 
        35                  40                  45              


Pro Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp 
    50                  55                  60                  


Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu 
65                  70                  75                  80  


Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile 
                85                  90                  95      


Leu Thr Ile Leu Gln Gln Phe Ser Lys Gly Glu Leu Asn Ser Lys Leu 
            100                 105                 110         


Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg 
        115                 120                 125             


Thr Gly His His His His His His 
    130                 135     


<210>  64
<211>  411
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding canine IL-31 protein with C-terminal
       truncation at position 20-122

<400>  64
atgctcgaat tacaaccttt atcccgcggt ctgctcgaag attaccaaaa aaaagaaaca     60

ggcgtcccag aaagcaaccg tacattactc ctttgcctta cctccgattc ccaaccacct    120

cgtcttaact catcagccat tctcccttat ttccgtgcca ttcgccctct ttctgataaa    180

aatattattg acaaaattat tgaacaactc gacaaattaa aattccaaca cgaacccgaa    240

accgaaatct ccgtacctgc cgataccttt gaatgcaaat cctttatcct cactatttta    300

caacaattct ccaagggcga gctcaattcg aagcttgaag gtaagcctat ccctaaccct    360

ctcctcggtc tcgattctac gcgtaccggt catcatcacc atcaccattg a             411


<210>  65
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence corresponding to canine IL-31 protein with 
       C-terminal truncation at position 20-100

<400>  65

Met Leu Glu Leu Gln Pro Leu Ser Arg Gly Leu Leu Glu Asp Tyr Gln 
1               5                   10                  15      


Lys Lys Glu Thr Gly Val Pro Glu Ser Asn Arg Thr Leu Leu Leu Cys 
            20                  25                  30          


Leu Thr Ser Asp Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala Ile Leu 
        35                  40                  45              


Pro Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp 
    50                  55                  60                  


Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu 
65                  70                  75                  80  


Thr Glu Lys Gly Glu Leu Asn Ser Lys Leu Glu Gly Lys Pro Ile Pro 
                85                  90                  95      


Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg Thr Gly His His His His 
            100                 105                 110         


His His 
        


<210>  66
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding canine IL-31 protein with C-terminal
       truncation at position 20-100

<400>  66
atgctcgaat tacaaccttt atcccgcggt ctgctcgaag attaccaaaa aaaagaaaca     60

ggcgtcccag aaagcaaccg tacattactc ctttgcctta cctccgattc ccaaccacct    120

cgtcttaact catcagccat tctcccttat ttccgtgcca ttcgccctct ttctgataaa    180

aatattattg acaaaattat tgaacaactc gacaaattaa aattccaaca cgaacccgaa    240

accgaaaagg gcgagctcaa ttcgaagctt gaaggtaagc ctatccctaa ccctctcctc    300

ggtctcgatt ctacgcgtac cggtcatcat caccatcacc attga                    345


<210>  67
<211>  94
<212>  PRT
<213>  Artificial

<220>
<223>  amino acid sequence corresponding to canine IL-31 protein with 
       C-terminal truncation at position 20-80

<400>  67

Met Leu Glu Leu Gln Pro Leu Ser Arg Gly Leu Leu Glu Asp Tyr Gln 
1               5                   10                  15      


Lys Lys Glu Thr Gly Val Pro Glu Ser Asn Arg Thr Leu Leu Leu Cys 
            20                  25                  30          


Leu Thr Ser Asp Ser Gln Pro Pro Arg Leu Asn Ser Ser Ala Ile Leu 
        35                  40                  45              


Pro Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Lys Gly 
    50                  55                  60                  


Glu Leu Asn Ser Lys Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu 
65                  70                  75                  80  


Gly Leu Asp Ser Thr Arg Thr Gly His His His His His His 
                85                  90                  


<210>  68
<211>  285
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding canine IL-31 protein with C-terminal
       truncation at position 20-80

<400>  68
atgctcgaat tacaaccttt atcccgcggt ctgctcgaag attaccaaaa aaaagaaaca     60

ggcgtcccag aaagcaaccg tacattactc ctttgcctta cctccgattc ccaaccacct    120

cgtcttaact catcagccat tctcccttat ttccgtgcca ttcgccctct ttctgataaa    180

aatattaagg gcgagctcaa ttcgaagctt gaaggtaagc ctatccctaa ccctctcctc    240

ggtctcgatt ctacgcgtac cggtcatcat caccatcacc attga                    285


<210>  69
<211>  444
<212>  DNA
<213>  Felis catus

<400>  69
atgagaggat cccatcacca tcaccaccac ggctcatctc atatggcccc cgcacatcgc     60

ctgcagccga gtgacattcg taaaattatc ttggagctgc gcccgatgtc caagggctta    120

ctgcaggatt atctgaagaa agagatcggg ctgcctgaaa gcaaccatag tagcctgccg    180

tgtttatcgt ctgatagcca gttaccacac atcaatggct ctgcgatttt gccctacttt    240

cgcgccatcc gtccgctgtc cgataaaaat accatcgaca aaattatcga acaactggat    300

aaattgaagt ttcagcgcga gcctgaagcg aaagtttcga tgccagcmga taacttcgaa    360

cgcaaaaact ttattttagc ggtgttgcag cagttttctg cctgtctgga acacgtgctc    420

cagtcactca atagtgggcc acaa                                           444


<210>  70
<211>  148
<212>  PRT
<213>  Felis catus

<400>  70

Met Arg Gly Ser His His His His His His Gly Ser Ser His Met Ala 
1               5                   10                  15      


Pro Ala His Arg Leu Gln Pro Ser Asp Ile Arg Lys Ile Ile Leu Glu 
            20                  25                  30          


Leu Arg Pro Met Ser Lys Gly Leu Leu Gln Asp Tyr Leu Lys Lys Glu 
        35                  40                  45              


Ile Gly Leu Pro Glu Ser Asn His Ser Ser Leu Pro Cys Leu Ser Ser 
    50                  55                  60                  


Asp Ser Gln Leu Pro His Ile Asn Gly Ser Ala Ile Leu Pro Tyr Phe 
65                  70                  75                  80  


Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Thr Ile Asp Lys Ile Ile 
                85                  90                  95      


Glu Gln Leu Asp Lys Leu Lys Phe Gln Arg Glu Pro Glu Ala Lys Val 
            100                 105                 110         


Ser Met Pro Ala Asp Asn Phe Glu Arg Lys Asn Phe Ile Leu Ala Val 
        115                 120                 125             


Leu Gln Gln Phe Ser Ala Cys Leu Glu His Val Leu Gln Ser Leu Asn 
    130                 135                 140                 


Ser Gly Pro Gln 
145             


<210>  71
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  felinized variable light chain mAb sequence, from Mus musculus 
       and Felis catus

<400>  71

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Phe Ala 
            20                  25                  30          


Gly Thr Gly Leu Met His Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      


Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  72
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a felinized variable light chain mAb
       sequence, from Mus musculus and Felis catus

<400>  72
gagattcaaa tgacccagag tcctagctca ctgagcgcat cacccgggga ccgcgtgacc     60

atcacgtgca aggcatctca gtccgtgtca ttcgctggaa ccggtctgat gcactggtat    120

cagcaaaaac cagggaaagt ccctaaactg ctgatctatc gcgcctccaa tcttgaggcc    180

ggggtgccat ctcggttctc tggtagcggc agcggaactg actttaccct gacaatctcc    240

tcactcgagc ctgaagacgc cgccacctac tactgtcaac agtccagaga atacccatgg    300

acctttggac agggtaccaa gctggagatc aaa                                 333


<210>  73
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  felinized variable heavy chain mAb sequence, from Mus musculus 
       and Felis catus

<400>  73

Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Val Ala Ser Gly Phe Thr Tyr Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Tyr Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Asn Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Tyr Gly Tyr Asp Thr Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  74
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding a felinized variable heavy chain mAb
       sequence, from Mus musculus and Felis catus

<400>  74
gacgtgcaac tggtcgaaag cggaggcgat cttgtgaagc caggtgggag tctccggctc     60

acatgcgtgg cctctggctt tacctacagc aactacggga tgagttgggt tcgccaggca    120

ccaggaaagg gcctgcaatg ggtggccact ataagctatg gtgggtccta tacctactac    180

cctgataata tcaaggggag attcactatt tcccgcgaca atgctaagaa tactctctac    240

ctccagatga atagcctgaa gactgaggat accgctacct actattgcgt gcgcggctac    300

ggctacgata ccatggacta ctggggacag ggaacccttg tcactgtctc gagc          354


<210>  75
<211>  335
<212>  PRT
<213>  Felis catus

<400>  75

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Thr Thr Ser Gly Ala Thr Val Ala Leu Ala Cys Leu Val Leu Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Leu Ser Asp Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln 
145                 150                 155                 160 


Ile Thr Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys 
        195                 200                 205             


Val Asn Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala 
225                 230                 235                 240 


Gln Glu Glu Leu Ser Arg Asn Lys Val Ser Val Thr Cys Leu Ile Lys 
                245                 250                 255     


Ser Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln 
            260                 265                 270         


Pro Glu Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser 
        275                 280                 285             


Asp Gly Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His 
    290                 295                 300                 


Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu 
305                 310                 315                 320 


His Ser His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
                325                 330                 335 


<210>  76
<211>  1005
<212>  DNA
<213>  Felis catus

<400>  76
gcctccacca cggccccatc ggtgttccca ctggccccca gctgcgggac cacatctggc     60

gccaccgtgg ccctggcctg cctggtgtta ggctacttcc ctgagccggt gaccgtgtcc    120

tggaactccg gcgccctgac cagcggtgtg cacaccttcc cggccgtcct gcaggcctcg    180

gggctgtact ctctcagcag catggtgaca gtgccctcca gcaggtggct cagtgacacc    240

ttcacctgca acgtggccca cccgcccagc aacaccaagg tggacaagac cgtgcgcaaa    300

acagaccacc caccgggacc caaaccctgc gactgtccca aatgcccacc ccctgagatg    360

cttggaggac cgtccatctt catcttcccc ccaaaaccca aggacaccct ctcgatttcc    420

cggacgcccg aggtcacatg cttggtggtg gacttgggcc cagatgactc cgatgtccag    480

atcacatggt ttgtggataa cacccaggtg tacacagcca agacgagtcc gcgtgaggag    540

cagttcaaca gcacctaccg tgtggtcagt gtcctcccca tcctacacca ggactggctc    600

aaggggaagg agttcaagtg caaggtcaac agcaaatccc tcccctcccc catcgagagg    660

accatctcca aggccaaagg acagccccac gagccccagg tgtacgtcct gcctccagcc    720

caggaggagc tcagcaggaa caaagtcagt gtgacctgcc tgatcaaatc cttccacccg    780

cctgacattg ccgtcgagtg ggagatcacc ggacagccgg agccagagaa caactaccgg    840

acgaccccgc cccagctgga cagcgacggg acctacttcg tgtacagcaa gctctcggtg    900

gacaggtccc actggcagag gggaaacacc tacacctgct cggtgtcaca cgaagctctg    960

cacagccacc acacacagaa atccctcacc cagtctccgg gtaaa                   1005


<210>  77
<211>  110
<212>  PRT
<213>  Felis catus

<400>  77

Arg Ser Asp Ala Gln Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp 
1               5                   10                  15      


Glu Leu His Thr Gly Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe 
            20                  25                  30          


Tyr Pro Lys Glu Val Asn Val Lys Trp Lys Val Asp Gly Val Val Gln 
        35                  40                  45              


Asn Lys Gly Ile Gln Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Gln 
65                  70                  75                  80  


Ser His Glu Lys Phe Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser 
                85                  90                  95      


Thr Leu Val Lys Ser Phe Asn Arg Ser Glu Cys Gln Arg Glu 
            100                 105                 110 


<210>  78
<211>  330
<212>  DNA
<213>  Felis catus

<400>  78
cggagtgatg ctcagccatc tgtctttctc ttccaaccat ctctggacga gttacataca     60

ggaagtgcct ctatcgtgtg catattgaat gacttctacc ccaaagaggt caatgtcaag    120

tggaaagtgg atggcgtagt ccaaaacaaa ggcatccagg agagcaccac agagcagaac    180

agcaaggaca gcacctacag cctcagcagc accctgacga tgtccagtac ggagtaccaa    240

agtcatgaaa agttctcctg cgaggtcact cacaagagcc tggcctccac cctcgtcaag    300

agcttcaaca ggagcgagtg tcagagagag                                     330


