                         SEQUENCE LISTING

<110>  Philogen S.P.A.
       Wuhlfard, Sarah
 
<120>  IL-12 Immunoconjugate

<130>  HMK/FP6827505

<150>  US 61/512,190
<151>  2011-07-27

<160>  49    

<170>  PatentIn version 3.3

<210>  1
<211>  3003
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: P40p35F8F8 nucleotide sequence

<400>  1
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct     60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg    120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt    180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg    240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa    300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc    360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct    420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg    480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct    540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac    600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag    660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg    720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag    780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa    840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg    900

gcatctgtgc cctgcagtgg tggaggcggt tcaggcggag gtggctctgg cggtggcgga    960

tcgagaaacc tccccgtggc cactccagac ccaggaatgt tcccatgcct tcaccactcc   1020

caaaacctgc tgagggccgt cagcaacatg ctccagaagg ccagacaaac tctagaattt   1080

tacccttgca cttctgaaga gattgatcat gaagatatca caaaagataa aaccagcaca   1140

gtggaggcct gtttaccatt ggaattaacc aagaatgaga gttgcctaaa ttccagagag   1200

acctctttca taactaatgg gagttgcctg gcctccagaa agacctcttt tatgatggcc   1260

ctgtgcctta gtagtattta tgaagacttg aagatgtacc aggtggagtt caagaccatg   1320

aatgcaaagc ttctgatgga tcctaagagg cagatctttc tagatcaaaa catgctggca   1380

gttattgatg agctgatgca ggccctgaat ttcaacagtg agactgtgcc acaaaaatcc   1440

tcccttgaag aaccggattt ttataaaact aaaatcaagc tctgcatact tcttcatgct   1500

ttcagaattc gggcagtgac tattgataga gtgatgagct atctgaatgc ttccggtagc   1560

gctgatggag gtgaggtgca gctgttggag tctgggggag gcttggtaca gcctgggggg   1620

tccctgagac tctcctgtgc agcctctgga ttcaccttta gcctgtttac gatgagctgg   1680

gtccgccagg ctccagggaa ggggctggag tgggtctcag ctattagtgg tagtggtggt   1740

agcacatact acgcagactc cgtgaagggc cggttcacca tctccagaga caattccaag   1800

aacacgctgt atctgcaaat gaacagcctg agagccgagg acacggccgt atattactgt   1860

gcgaaaagta ctcatttgta tctttttgac tactggggcc agggaaccct ggtcaccgtc   1920

tcgagtggcg gtagcggagg ggaaattgtg ttgacgcagt ctccaggcac cctgtctttg   1980

tctccagggg aaagagccac cctctcctgc agggccagtc agagtgttag catgccgttt   2040

ttagcctggt accagcagaa acctggccag gctcccaggc tcctcatcta tggtgcatcc   2100

agcagggcca ctggcatccc agacaggttc agtggcagtg ggtctgggac agacttcact   2160

ctcaccatca gcagactgga gcctgaagat tttgcagtgt attactgtca gcagatgcgt   2220

ggtcggccgc cgacgttcgg ccaagggacc aaggtggaaa tcaaatcttc ctcatccgga   2280

agtagctctt ccggctcatc gtccagcggc gaggtgcagc tgttggagtc tgggggaggc   2340

ttggtacagc ctggggggtc cctgagactc tcctgtgcag cctctggatt cacctttagc   2400

ctgtttacga tgagctgggt ccgccaggct ccagggaagg ggctggagtg ggtctcagct   2460

attagtggta gtggtggtag cacatactac gcagactccg tgaagggccg gttcaccatc   2520

tccagagaca attccaagaa cacgctgtat ctgcaaatga acagcctgag agccgaggac   2580

acggccgtat attactgtgc gaaaagtact catttgtatc tttttgacta ctggggccag   2640

ggaaccctgg tcaccgtctc gagtggcggt agcggagggg aaattgtgtt gacgcagtct   2700

ccaggcaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag ggccagtcag   2760

agtgttagca tgccgttttt agcctggtac cagcagaaac ctggccaggc tcccaggctc   2820

ctcatctatg gtgcatccag cagggccact ggcatcccag acaggttcag tggcagtggg   2880

tctgggacag acttcactct caccatcagc agactggagc ctgaagattt tgcagtgtat   2940

tactgtcagc agatgcgtgg tcggccgccg acgttcggcc aagggaccaa ggtggaaatc   3000

aaa                                                                 3003


<210>  2
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  2
ctgtttacg                                                              9


<210>  3
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  3
agtggtagtg gtggtagc                                                   18


<210>  4
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  4
agtactcatt tgtatctt                                                   18


<210>  5
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  5
atgccgttt                                                              9


<210>  6
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6
ggtgcatcca gcagggccac t                                               21


<210>  7
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  7
atgcgtggtc ggccgccg                                                   18


<210>  8
<211>  1001
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: P40p35F8F8 amino acid sequence

<400>  8

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser Gly Ser Ala Asp Gly Gly Glu Val Gln Leu 
        515                 520                 525             


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    530                 535                 540                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe Thr Met Ser Trp 
545                 550                 555                 560 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser 
                565                 570                 575     


Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            580                 585                 590         


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        595                 600                 605             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Thr 
    610                 615                 620                 


His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
625                 630                 635                 640 


Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
                645                 650                 655     


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
            660                 665                 670         


Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro 
        675                 680                 685             


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
    690                 695                 700                 


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
705                 710                 715                 720 


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
                725                 730                 735     


Gln Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
            740                 745                 750         


Glu Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser 
        755                 760                 765             


Ser Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
    770                 775                 780                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
785                 790                 795                 800 


Leu Phe Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                805                 810                 815     


Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp 
            820                 825                 830         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
        835                 840                 845             


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    850                 855                 860                 


Tyr Cys Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln 
865                 870                 875                 880 


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val 
                885                 890                 895     


Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
            900                 905                 910         


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro Phe Leu Ala 
        915                 920                 925             


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly 
    930                 935                 940                 


Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly 
945                 950                 955                 960 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp 
                965                 970                 975     


Phe Ala Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro Pro Thr Phe 
            980                 985                 990         


Gly Gln Gly Thr Lys Val Glu Ile  Lys 
        995                 1000     


<210>  9
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Phe Thr 
1           


<210>  10
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Ile Ser Gly Ser 
1               5   


<210>  11
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Thr His Leu Tyr Leu 
1               5       


<210>  12
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Phe 
1           


<210>  13
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  14
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Gly Arg Pro Pro 
1               5       


<210>  15
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  16
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  17
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  17

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  18
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210>  19
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Peptide linker sequence

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  20
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Peptide linker sequence

<400>  20

Gly Ser Ala Asp Gly Gly 
1               5       


<210>  21
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Peptide linker sequence

<400>  21

Gly Gly Ser Gly Gly 
1               5   


<210>  22
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Peptide linker sequence

<400>  22

Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly 
1               5                   10                  15  


<210>  23
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  23
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt cacctttagc ctgtttacga tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac    180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaagtact    300

catttgtatc tttttgacta ctggggccag ggaaccctgg tcaccgtctc gagt          354


<210>  24
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  24
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc atgccgtttt tagcctggta ccagcagaaa    120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca    180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    240

cctgaagatt ttgcagtgta ttactgtcag cagatgcgtg gtcggccgcc gacgttcggc    300

caagggacca aggtggaaat caaa                                           324


<210>  25
<211>  918
<212>  DNA
<213>  Homo sapiens

<400>  25
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct     60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg    120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt    180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg    240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa    300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc    360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct    420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg    480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct    540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac    600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag    660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg    720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag    780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa    840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg    900

gcatctgtgc cctgcagt                                                  918


<210>  26
<211>  591
<212>  DNA
<213>  Homo sapiens

<400>  26
agaaacctcc ccgtggccac tccagaccca ggaatgttcc catgccttca ccactcccaa     60

aacctgctga gggccgtcag caacatgctc cagaaggcca gacaaactct agaattttac    120

ccttgcactt ctgaagagat tgatcatgaa gatatcacaa aagataaaac cagcacagtg    180

gaggcctgtt taccattgga attaaccaag aatgagagtt gcctaaattc cagagagacc    240

tctttcataa ctaatgggag ttgcctggcc tccagaaaga cctcttttat gatggccctg    300

tgccttagta gtatttatga agacttgaag atgtaccagg tggagttcaa gaccatgaat    360

gcaaagcttc tgatggatcc taagaggcag atctttctag atcaaaacat gctggcagtt    420

attgatgagc tgatgcaggc cctgaatttc aacagtgaga ctgtgccaca aaaatcctcc    480

cttgaagaac cggattttta taaaactaaa atcaagctct gcatacttct tcatgctttc    540

agaattcggg cagtgactat tgatagagtg atgagctatc tgaatgcttc c             591


<210>  27
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: linker sequence

<400>  27
ggtggaggcg gttcaggcgg aggtggctct ggcggtggcg gatcg                     45


<210>  28
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: linker sequence

<400>  28
ggtagcgctg atggaggt                                                   18


<210>  29
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: linker sequence

<400>  29
ggcggtagcg gaggg                                                      15


<210>  30
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: linker sequence

<400>  30
tcttcctcat ccggaagtag ctcttccggc tcatcgtcca gcggc                     45


<210>  31
<211>  1431
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: F8 single chain diabody sequence

<400>  31
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt cacctttagc ctgtttacga tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac    180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaagtact    300

catttgtatc tttttgacta ctggggccag ggaaccctgg tcaccgtctc gagtggcggt    360

agcggagggg aaattgtgtt gacgcagtct ccaggcaccc tgtctttgtc tccaggggaa    420

agagccaccc tctcctgcag ggccagtcag agtgttagca tgccgttttt agcctggtac    480

cagcagaaac ctggccaggc tcccaggctc ctcatctatg gtgcatccag cagggccact    540

ggcatcccag acaggttcag tggcagtggg tctgggacag acttcactct caccatcagc    600

agactggagc ctgaagattt tgcagtgtat tactgtcagc agatgcgtgg tcggccgccg    660

acgttcggcc aagggaccaa ggtggaaatc aaatcttcct catccggaag tagctcttcc    720

ggctcatcgt ccagcggcga ggtgcagctg ttggagtctg ggggaggctt ggtacagcct    780

ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttagcct gtttacgatg    840

agctgggtcc gccaggctcc agggaagggg ctggagtggg tctcagctat tagtggtagt    900

ggtggtagca catactacgc agactccgtg aagggccggt tcaccatctc cagagacaat    960

tccaagaaca cgctgtatct gcaaatgaac agcctgagag ccgaggacac ggccgtatat   1020

tactgtgcga aaagtactca tttgtatctt tttgactact ggggccaggg aaccctggtc   1080

accgtctcga gtggcggtag cggaggggaa attgtgttga cgcagtctcc aggcaccctg   1140

tctttgtctc caggggaaag agccaccctc tcctgcaggg ccagtcagag tgttagcatg   1200

ccgtttttag cctggtacca gcagaaacct ggccaggctc ccaggctcct catctatggt   1260

gcatccagca gggccactgg catcccagac aggttcagtg gcagtgggtc tgggacagac   1320

ttcactctca ccatcagcag actggagcct gaagattttg cagtgtatta ctgtcagcag   1380

atgcgtggtc ggccgccgac gttcggccaa gggaccaagg tggaaatcaa a            1431


<210>  32
<211>  680
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: F8 single chain diabody sequence

<400>  32

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser Gly Ser Ala Asp Gly Gly Glu Val Gln Leu Leu 
        195                 200                 205             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    210                 215                 220                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Phe Thr Met Ser Trp Val 
225                 230                 235                 240 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly 
                245                 250                 255     


Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            260                 265                 270         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        275                 280                 285             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Thr His 
    290                 295                 300                 


Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
305                 310                 315                 320 


Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr 
                325                 330                 335     


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
            340                 345                 350         


Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        355                 360                 365             


Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly 
    370                 375                 380                 


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
385                 390                 395                 400 


Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
                405                 410                 415     


Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
            420                 425                 430         


Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser 
        435                 440                 445             


Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    450                 455                 460                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu 
465                 470                 475                 480 


Phe Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                485                 490                 495     


Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
            500                 505                 510         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
        515                 520                 525             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    530                 535                 540                 


Cys Ala Lys Ser Thr His Leu Tyr Leu Phe Asp Tyr Trp Gly Gln Gly 
545                 550                 555                 560 


Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu 
                565                 570                 575     


Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
            580                 585                 590         


Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp 
        595                 600                 605             


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala 
    610                 615                 620                 


Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser 
625                 630                 635                 640 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe 
                645                 650                 655     


Ala Val Tyr Tyr Cys Gln Gln Met Arg Gly Arg Pro Pro Thr Phe Gly 
            660                 665                 670         


Gln Gly Thr Lys Val Glu Ile Lys 
        675                 680 


<210>  33
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  34
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  35
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  35

Ser Phe Ser Met Ser 
1               5   


<210>  36
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  36

Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  37
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  37

Pro Phe Pro Tyr Phe Asp Tyr 
1               5           


<210>  38
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  38

Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala 
1               5                   10          


<210>  39
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  39

Tyr Ala Ser Ser Arg Ala Thr 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Gln Thr Gly Arg Ile Pro Pro Thr 
1               5                   


<210>  41
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Asp Gly Ser Ser Gly Gly Ser Gly Gly Ala Ser 
        115                 120                 125             


Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
    130                 135                 140                 


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
145                 150                 155                 160 


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
                165                 170                 175     


Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
        195                 200                 205             


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro 
    210                 215                 220                 


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235     


<210>  42
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala His Asn Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Arg 
        115     


<210>  43
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  43

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ser Val Tyr Thr Met Pro Pro 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  44
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  44

Arg Tyr Gly Met Ser 
1               5   


<210>  45
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  45

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  46
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  46

Ala His Asn Ala Phe Asp Tyr 
1               5           


<210>  47
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  47

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  48
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  48

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  49
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  49

Asn Ser Ser Val Tyr Thr Met Pro Pro Val Val 
1               5                   10      


