                         SEQUENCE LISTING

<110>  Novozymes North America, Inc.
       Gaspar, Armindo Ribiero
       Xu, Hui
       Croonenberghs, James
       Luo, James
       Rane, Kishore
 
<120>  Processes For Pretreating Cellulosic Material And Improving 
       Hydrolysis Thereof

<130>  12045-WO-PCT

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  194
<212>  PRT
<213>  Humicola insolens cutinase

<400>  1

Gln Leu Gly Ala Ile Gln Asn Asp Leu Glu Ser Gly Ser Pro Asp Ala 
1               5                   10                  15      


Cys Pro Asp Ala Ile Leu Ile Phe Ala Arg Gly Ser Thr Glu Pro Gly 
            20                  25                  30          


Asn Met Gly Ile Thr Val Gly Pro Ala Leu Ala Asn Gly Leu Lys Glu 
        35                  40                  45              


His Ile Pro Asn Ile Trp Ile Gln Gly Val Gly Gly Pro Tyr Asp Ala 
    50                  55                  60                  


Ala Leu Ala Thr Asn Phe Leu Pro Arg Gly Thr Ser Gln Ala Asn Ile 
65                  70                  75                  80  


Asp Glu Gly Lys Arg Leu Phe His Leu Ala His Gln Lys Cys Pro Asn 
                85                  90                  95      


Thr Pro Val Val Ala Gly Gly Tyr Ser Gln Gly Ala Ala Leu Ile Ala 
            100                 105                 110         


Ala Ala Val Ser Glu Leu Ser Gly Ala Val Lys Glu Gln Val Lys Gly 
        115                 120                 125             


Val Val Leu Phe Gly Tyr Thr Gln Asn Leu Gln Asn Arg Gly Gly Ile 
    130                 135                 140                 


Pro Asn Tyr Pro Arg Glu Arg Thr Lys Val Phe Cys Asn Val Gly Asp 
145                 150                 155                 160 


Ala Val Cys Thr Gly Thr Leu Ile Ile Thr Pro Ala His Leu Ser Tyr 
                165                 170                 175     


Thr Ile Gln Ala Arg Gly Glu Ala Ala Arg Phe Leu Val Asp Arg Ile 
            180                 185                 190         


Arg Ala 
        


<210>  2
<211>  270
<212>  PRT
<213>  Mature savinase bacillus lentus

<400>  2

Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala 
1               5                   10                  15      


His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser 
        35                  40                  45              


Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr 
    50                  55                  60                  


His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu 
65                  70                  75                  80  


Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala 
                85                  90                  95      


Ser Glu Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp 
            100                 105                 110         


Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro 
        115                 120                 125             


Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg 
    130                 135                 140                 


Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile 
145                 150                 155                 160 


Ser Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp 
                165                 170                 175     


Gln Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp 
            180                 185                 190         


Ile Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr 
        195                 200                 205             


Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly 
    210                 215                 220                 


Ala Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln 
225                 230                 235                 240 


Ile Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn 
                245                 250                 255     


Leu Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            260                 265                 270 


<210>  3
<211>  385
<212>  PRT
<213>  Aspergillus aculeatus

<400>  3

Lys Thr Ser Met His Leu Asn Thr Thr Leu Leu Val Ser Leu Ala Leu 
1               5                   10                  15      


Gly Ala Ala Ser Val Leu Ala Ser Pro Ala Pro Pro Ala Ile Thr Ala 
            20                  25                  30          


Pro Pro Thr Ala Glu Glu Ile Ala Lys Arg Ala Thr Thr Cys Thr Phe 
        35                  40                  45              


Ser Gly Ser Asn Gly Ala Ser Ser Ala Ser Lys Ser Lys Thr Ser Cys 
    50                  55                  60                  


Ser Thr Ile Val Leu Ser Asn Val Ala Val Pro Ser Gly Thr Thr Leu 
65                  70                  75                  80  


Asp Leu Thr Lys Leu Asn Asp Gly Thr His Val Ile Phe Ser Gly Glu 
                85                  90                  95      


Thr Thr Phe Gly Tyr Lys Glu Trp Ser Gly Pro Leu Ile Ser Val Ser 
            100                 105                 110         


Gly Ser Asp Leu Thr Ile Thr Gly Ala Ser Gly His Ser Ile Asn Gly 
        115                 120                 125             


Asp Gly Ser Arg Trp Trp Asp Gly Glu Gly Gly Asn Gly Gly Lys Thr 
    130                 135                 140                 


Lys Pro Lys Phe Phe Ala Ala His Ser Leu Thr Asn Ser Val Ile Ser 
145                 150                 155                 160 


Gly Leu Lys Ile Val Asn Ser Pro Val Gln Val Phe Ser Val Ala Gly 
                165                 170                 175     


Ser Asp Tyr Leu Thr Leu Lys Asp Ile Thr Ile Asp Asn Ser Asp Gly 
            180                 185                 190         


Asp Asp Asn Gly Gly His Asn Thr Asp Ala Phe Asp Ile Gly Thr Ser 
        195                 200                 205             


Thr Tyr Val Thr Ile Ser Gly Ala Thr Val Tyr Asn Gln Asp Asp Cys 
    210                 215                 220                 


Val Ala Val Asn Ser Gly Glu Asn Ile Tyr Phe Ser Gly Gly Tyr Cys 
225                 230                 235                 240 


Ser Gly Gly His Gly Leu Ser Ile Gly Ser Val Gly Gly Arg Ser Asp 
                245                 250                 255     


Asn Thr Val Lys Asn Val Thr Phe Val Asp Ser Thr Ile Ile Asn Ser 
            260                 265                 270         


Asp Asn Gly Val Arg Ile Lys Thr Asn Ile Asp Thr Thr Gly Ser Val 
        275                 280                 285             


Ser Asp Val Thr Tyr Lys Asp Ile Thr Leu Thr Ser Ile Ala Lys Tyr 
    290                 295                 300                 


Gly Ile Val Val Gln Gln Asn Tyr Gly Asp Thr Ser Ser Thr Pro Thr 
305                 310                 315                 320 


Thr Gly Val Pro Ile Thr Asp Phe Val Leu Asp Asn Val His Gly Ser 
                325                 330                 335     


Val Val Ser Ser Gly Thr Asn Ile Leu Ile Ser Cys Gly Ser Gly Ser 
            340                 345                 350         


Cys Ser Asp Trp Thr Trp Thr Asp Val Ser Val Ser Gly Gly Lys Thr 
        355                 360                 365             


Ser Ser Lys Cys Thr Asn Val Pro Ser Gly Ala Ser Cys Asn Gly Ala 
    370                 375                 380                 


Ser 
385 


<210>  4
<211>  471
<212>  PRT
<213>  Rhizomucor pusillus amylase

<400>  4

Met Lys Phe Ser Ile Ser Leu Ser Ala Ala Ile Val Leu Phe Ala Ala 
1               5                   10                  15      


Ala Thr Ser Leu Ala Ser Pro Leu Pro Gln Gln Gln Arg Tyr Gly Lys 
            20                  25                  30          


Arg Ala Thr Ser Asp Asp Trp Lys Ser Lys Ala Ile Tyr Gln Leu Leu 
        35                  40                  45              


Thr Asp Arg Phe Gly Arg Ala Asp Asp Ser Thr Ser Asn Cys Ser Asn 
    50                  55                  60                  


Leu Ser Asn Tyr Cys Gly Gly Thr Tyr Glu Gly Ile Thr Lys His Leu 
65                  70                  75                  80  


Asp Tyr Ile Ser Gly Met Gly Phe Asp Ala Ile Trp Ile Ser Pro Ile 
                85                  90                  95      


Pro Lys Asn Ser Asp Gly Gly Tyr His Gly Tyr Trp Ala Thr Asp Phe 
            100                 105                 110         


Tyr Gln Leu Asn Ser Asn Phe Gly Asp Glu Ser Gln Leu Lys Ala Leu 
        115                 120                 125             


Ile Gln Ala Ala His Glu Arg Asp Met Tyr Val Met Leu Asp Val Val 
    130                 135                 140                 


Ala Asn His Ala Gly Pro Thr Ser Asn Gly Tyr Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Gly Asp Ala Ser Leu Tyr His Pro Lys Cys Thr Ile Asp Tyr Asn Asp 
                165                 170                 175     


Gln Thr Ser Ile Glu Gln Cys Trp Val Ala Asp Glu Leu Pro Asp Ile 
            180                 185                 190         


Asp Thr Glu Asn Ser Asp Asn Val Ala Ile Leu Asn Asp Ile Val Ser 
        195                 200                 205             


Gly Trp Val Gly Asn Tyr Ser Phe Asp Gly Ile Arg Ile Asp Thr Val 
    210                 215                 220                 


Lys His Ile Arg Lys Asp Phe Trp Thr Gly Tyr Ala Glu Ala Ala Gly 
225                 230                 235                 240 


Val Phe Ala Thr Gly Glu Val Phe Asn Gly Asp Pro Ala Tyr Val Gly 
                245                 250                 255     


Pro Tyr Gln Lys Tyr Leu Pro Ser Leu Ile Asn Tyr Pro Met Tyr Tyr 
            260                 265                 270         


Ala Leu Asn Asp Val Phe Val Ser Lys Ser Lys Gly Phe Ser Arg Ile 
        275                 280                 285             


Ser Glu Met Leu Gly Ser Asn Arg Asn Ala Phe Glu Asp Thr Ser Val 
    290                 295                 300                 


Leu Thr Thr Phe Val Asp Asn His Asp Asn Pro Arg Phe Leu Asn Ser 
305                 310                 315                 320 


Gln Ser Asp Lys Ala Leu Phe Lys Asn Ala Leu Thr Tyr Val Leu Leu 
                325                 330                 335     


Gly Glu Gly Ile Pro Ile Val Tyr Tyr Gly Ser Glu Gln Gly Phe Ser 
            340                 345                 350         


Gly Gly Ala Asp Pro Ala Asn Arg Glu Val Leu Trp Thr Thr Asn Tyr 
        355                 360                 365             


Asp Thr Ser Ser Asp Leu Tyr Gln Phe Ile Lys Thr Val Asn Ser Val 
    370                 375                 380                 


Arg Met Lys Ser Asn Lys Ala Val Tyr Met Asp Ile Tyr Val Gly Asp 
385                 390                 395                 400 


Asn Ala Tyr Ala Phe Lys His Gly Asp Ala Leu Val Val Leu Asn Asn 
                405                 410                 415     


Tyr Gly Ser Gly Ser Thr Asn Gln Val Ser Phe Ser Val Ser Gly Lys 
            420                 425                 430         


Phe Asp Ser Gly Ala Ser Leu Met Asp Ile Val Ser Asn Ile Thr Thr 
        435                 440                 445             


Thr Val Ser Ser Asp Gly Thr Val Thr Phe Asn Leu Lys Asp Gly Leu 
    450                 455                 460                 


Pro Ala Ile Phe Thr Ser Ala 
465                 470     


<210>  5
<211>  383
<212>  PRT
<213>  Aspergillus niger mannanase

<400>  5

Met Lys Leu Ser Asn Ala Leu Leu Thr Leu Ala Ser Leu Ala Leu Ala 
1               5                   10                  15      


Asn Val Ser Thr Ala Leu Pro Lys Ala Ser Pro Ala Pro Ser Thr Ser 
            20                  25                  30          


Ser Ser Ala Ala Ser Thr Ser Phe Ala Ser Thr Ser Gly Leu Gln Phe 
        35                  40                  45              


Thr Ile Asp Gly Glu Thr Gly Tyr Phe Ala Gly Thr Asn Ser Tyr Trp 
    50                  55                  60                  


Ile Gly Phe Leu Thr Asp Asn Ser Asp Val Asp Leu Val Met Ser His 
65                  70                  75                  80  


Leu Lys Ser Ser Gly Leu Lys Ile Leu Arg Val Trp Gly Phe Asn Asp 
                85                  90                  95      


Val Thr Ser Gln Pro Ser Ser Gly Thr Val Trp Tyr Gln Leu His Gln 
            100                 105                 110         


Asp Gly Lys Ser Thr Ile Asn Thr Gly Ala Asp Gly Leu Gln Arg Leu 
        115                 120                 125             


Asp Tyr Val Val Ser Ser Ala Glu Gln His Asp Ile Lys Leu Ile Ile 
    130                 135                 140                 


Asn Phe Val Asn Tyr Trp Thr Asp Tyr Gly Gly Met Ser Ala Tyr Val 
145                 150                 155                 160 


Ser Ala Tyr Gly Gly Ser Asp Glu Thr Asp Phe Tyr Thr Ser Asp Thr 
                165                 170                 175     


Ile Gln Ser Ala Tyr Gln Thr Tyr Ile Lys Thr Val Val Glu Arg Tyr 
            180                 185                 190         


Ser Asn Ser Ser Ala Val Phe Ala Trp Glu Leu Ala Asn Glu Pro Arg 
        195                 200                 205             


Cys Pro Ser Cys Asp Thr Ser Val Leu Tyr Asn Trp Ile Glu Lys Thr 
    210                 215                 220                 


Ser Lys Phe Ile Lys Gly Leu Asp Ala Asp His Met Val Cys Ile Gly 
225                 230                 235                 240 


Asp Glu Gly Phe Gly Leu Asn Ile Asp Ser Asp Gly Ser Tyr Pro Tyr 
                245                 250                 255     


Gln Phe Ser Glu Gly Leu Asn Phe Thr Met Asn Leu Gly Ile Asp Thr 
            260                 265                 270         


Ile Asp Phe Gly Thr Leu His Leu Tyr Pro Asp Ser Trp Gly Thr Ser 
        275                 280                 285             


Asp Asp Trp Gly Asn Gly Trp Ile Thr Ala His Gly Ala Ala Cys Lys 
    290                 295                 300                 


Ala Ala Gly Lys Pro Cys Leu Leu Glu Glu Tyr Gly Val Thr Ser Asn 
305                 310                 315                 320 


His Cys Ser Val Glu Ser Pro Trp Gln Lys Thr Ala Leu Asn Thr Thr 
                325                 330                 335     


Gly Val Gly Ala Asp Leu Phe Trp Gln Tyr Gly Asp Asp Leu Ser Thr 
            340                 345                 350         


Gly Lys Ser Pro Asp Asp Gly Asn Thr Ile Tyr Tyr Gly Thr Ser Asp 
        355                 360                 365             


Tyr Glu Cys Leu Val Thr Asp His Val Ala Ala Ile Gly Ser Ala 
    370                 375                 380             


<210>  6
<211>  591
<212>  PRT
<213>  Talaromices emersoni glucoamylase

<400>  6

Ala Thr Gly Ser Leu Asp Ser Phe Leu Ala Thr Glu Thr Pro Ile Ala 
1               5                   10                  15      


Leu Gln Gly Val Leu Asn Asn Ile Gly Pro Asn Gly Ala Asp Val Ala 
            20                  25                  30          


Gly Ala Ser Ala Gly Ile Val Val Ala Ser Pro Ser Arg Ser Asp Pro 
        35                  40                  45              


Asn Tyr Phe Tyr Ser Trp Thr Arg Asp Ala Ala Leu Thr Ala Lys Tyr 
    50                  55                  60                  


Leu Val Asp Ala Phe Asn Arg Gly Asn Lys Asp Leu Glu Gln Thr Ile 
65                  70                  75                  80  


Gln Gln Tyr Ile Ser Ala Gln Ala Lys Val Gln Thr Ile Ser Asn Pro 
                85                  90                  95      


Ser Gly Asp Leu Ser Thr Gly Gly Leu Gly Glu Pro Lys Phe Asn Val 
            100                 105                 110         


Asn Glu Thr Ala Phe Thr Gly Pro Trp Gly Arg Pro Gln Arg Asp Gly 
        115                 120                 125             


Pro Ala Leu Arg Ala Thr Ala Leu Ile Ala Tyr Ala Asn Tyr Leu Ile 
    130                 135                 140                 


Asp Asn Gly Glu Ala Ser Thr Ala Asp Glu Ile Ile Trp Pro Ile Val 
145                 150                 155                 160 


Gln Asn Asp Leu Ser Tyr Ile Thr Gln Tyr Trp Asn Ser Ser Thr Phe 
                165                 170                 175     


Asp Leu Trp Glu Glu Val Glu Gly Ser Ser Phe Phe Thr Thr Ala Val 
            180                 185                 190         


Gln His Arg Ala Leu Val Glu Gly Asn Ala Leu Ala Thr Arg Leu Asn 
        195                 200                 205             


His Thr Cys Ser Asn Cys Val Ser Gln Ala Pro Gln Val Leu Cys Phe 
    210                 215                 220                 


Leu Gln Ser Tyr Trp Thr Gly Ser Tyr Val Leu Ala Asn Phe Gly Gly 
225                 230                 235                 240 


Ser Gly Arg Ser Gly Lys Asp Val Asn Ser Ile Leu Gly Ser Ile His 
                245                 250                 255     


Thr Phe Asp Pro Ala Gly Gly Cys Asp Asp Ser Thr Phe Gln Pro Cys 
            260                 265                 270         


Ser Ala Arg Ala Leu Ala Asn His Lys Val Val Thr Asp Ser Phe Arg 
        275                 280                 285             


Ser Ile Tyr Ala Ile Asn Ser Gly Ile Ala Glu Gly Ser Ala Val Ala 
    290                 295                 300                 


Val Gly Arg Tyr Pro Glu Asp Val Tyr Gln Gly Gly Asn Pro Trp Tyr 
305                 310                 315                 320 


Leu Ala Thr Ala Ala Ala Ala Glu Gln Leu Tyr Asp Ala Ile Tyr Gln 
                325                 330                 335     


Trp Lys Lys Ile Gly Ser Ile Ser Ile Thr Asp Val Ser Leu Pro Phe 
            340                 345                 350         


Phe Gln Asp Ile Tyr Pro Ser Ala Ala Val Gly Thr Tyr Asn Ser Gly 
        355                 360                 365             


Ser Thr Thr Phe Asn Asp Ile Ile Ser Ala Val Gln Thr Tyr Gly Asp 
    370                 375                 380                 


Gly Tyr Leu Ser Ile Val Glu Lys Tyr Thr Pro Ser Asp Gly Ser Leu 
385                 390                 395                 400 


Thr Glu Gln Phe Ser Arg Thr Asp Gly Thr Pro Leu Ser Ala Ser Ala 
                405                 410                 415     


Leu Thr Trp Ser Tyr Ala Ser Leu Leu Thr Ala Ser Ala Arg Arg Gln 
            420                 425                 430         


Ser Val Val Pro Ala Ser Trp Gly Glu Ser Ser Ala Ser Ser Val Leu 
        435                 440                 445             


Ala Val Cys Ser Ala Thr Ser Ala Thr Gly Pro Tyr Ser Thr Ala Thr 
    450                 455                 460                 


Asn Thr Val Trp Pro Ser Ser Gly Ser Gly Ser Ser Thr Thr Thr Ser 
465                 470                 475                 480 


Ser Ala Pro Cys Thr Thr Pro Thr Ser Val Ala Val Thr Phe Asp Glu 
                485                 490                 495     


Ile Val Ser Thr Ser Tyr Gly Glu Thr Ile Tyr Leu Ala Gly Ser Ile 
            500                 505                 510         


Pro Glu Leu Gly Asn Trp Ser Thr Ala Ser Ala Ile Pro Leu Arg Ala 
        515                 520                 525             


Asp Ala Tyr Thr Asn Ser Asn Pro Leu Trp Tyr Val Thr Val Asn Leu 
    530                 535                 540                 


Pro Pro Gly Thr Ser Phe Glu Tyr Lys Phe Phe Lys Asn Gln Thr Asp 
545                 550                 555                 560 


Gly Thr Ile Val Trp Glu Asp Asp Pro Asn Arg Ser Tyr Thr Val Pro 
                565                 570                 575     


Ala Tyr Cys Gly Gln Thr Thr Ala Ile Leu Asp Asp Ser Trp Gln 
            580                 585                 590     


<210>  7
<211>  574
<212>  PRT
<213>  Trametes cingulata glucoamylase

<400>  7

Met Arg Phe Thr Leu Leu Thr Ser Leu Leu Gly Leu Ala Leu Gly Ala 
1               5                   10                  15      


Phe Ala Gln Ser Ser Ala Ala Asp Ala Tyr Val Ala Ser Glu Ser Pro 
            20                  25                  30          


Ile Ala Lys Ala Gly Val Leu Ala Asn Ile Gly Pro Ser Gly Ser Lys 
        35                  40                  45              


Ser Asn Gly Ala Lys Ala Gly Ile Val Ile Ala Ser Pro Ser Thr Ser 
    50                  55                  60                  


Asn Pro Asn Tyr Leu Tyr Thr Trp Thr Arg Asp Ser Ser Leu Val Phe 
65                  70                  75                  80  


Lys Ala Leu Ile Asp Gln Phe Thr Thr Gly Glu Asp Thr Ser Leu Arg 
                85                  90                  95      


Thr Leu Ile Asp Glu Phe Thr Ser Ala Glu Ala Ile Leu Gln Gln Val 
            100                 105                 110         


Pro Asn Pro Ser Gly Thr Val Ser Thr Gly Gly Leu Gly Glu Pro Lys 
        115                 120                 125             


Phe Asn Ile Asp Glu Thr Ala Phe Thr Asp Ala Trp Gly Arg Pro Gln 
    130                 135                 140                 


Arg Asp Gly Pro Ala Leu Arg Ala Thr Ala Ile Ile Thr Tyr Ala Asn 
145                 150                 155                 160 


Trp Leu Leu Asp Asn Lys Asn Thr Thr Tyr Val Thr Asn Thr Leu Trp 
                165                 170                 175     


Pro Ile Ile Lys Leu Asp Leu Asp Tyr Val Ala Ser Asn Trp Asn Gln 
            180                 185                 190         


Ser Thr Phe Asp Leu Trp Glu Glu Ile Asn Ser Ser Ser Phe Phe Thr 
        195                 200                 205             


Thr Ala Val Gln His Arg Ala Leu Arg Glu Gly Ala Thr Phe Ala Asn 
    210                 215                 220                 


Arg Ile Gly Gln Thr Ser Val Val Ser Gly Tyr Thr Thr Gln Ala Asn 
225                 230                 235                 240 


Asn Leu Leu Cys Phe Leu Gln Ser Tyr Trp Asn Pro Thr Gly Gly Tyr 
                245                 250                 255     


Ile Thr Ala Asn Thr Gly Gly Gly Arg Ser Gly Lys Asp Ala Asn Thr 
            260                 265                 270         


Val Leu Thr Ser Ile His Thr Phe Asp Pro Ala Ala Gly Cys Asp Ala 
        275                 280                 285             


Val Thr Phe Gln Pro Cys Ser Asp Lys Ala Leu Ser Asn Leu Lys Val 
    290                 295                 300                 


Tyr Val Asp Ala Phe Arg Ser Ile Tyr Ser Ile Asn Ser Gly Ile Ala 
305                 310                 315                 320 


Ser Asn Ala Ala Val Ala Thr Gly Arg Tyr Pro Glu Asp Ser Tyr Met 
                325                 330                 335     


Gly Gly Asn Pro Trp Tyr Leu Thr Thr Ser Ala Val Ala Glu Gln Leu 
            340                 345                 350         


Tyr Asp Ala Leu Ile Val Trp Asn Lys Leu Gly Ala Leu Asn Val Thr 
        355                 360                 365             


Ser Thr Ser Leu Pro Phe Phe Gln Gln Phe Ser Ser Gly Val Thr Val 
    370                 375                 380                 


Gly Thr Tyr Ala Ser Ser Ser Ser Thr Phe Lys Thr Leu Thr Ser Ala 
385                 390                 395                 400 


Ile Lys Thr Phe Ala Asp Gly Phe Leu Ala Val Asn Ala Lys Tyr Thr 
                405                 410                 415     


Pro Ser Asn Gly Gly Leu Ala Glu Gln Tyr Ser Arg Ser Asn Gly Ser 
            420                 425                 430         


Pro Val Ser Ala Val Asp Leu Thr Trp Ser Tyr Ala Ala Ala Leu Thr 
        435                 440                 445             


Ser Phe Ala Ala Arg Ser Gly Lys Thr Tyr Ala Ser Trp Gly Ala Ala 
    450                 455                 460                 


Gly Leu Thr Val Pro Thr Thr Cys Ser Gly Ser Gly Gly Ala Gly Thr 
465                 470                 475                 480 


Val Ala Val Thr Phe Asn Val Gln Ala Thr Thr Val Phe Gly Glu Asn 
                485                 490                 495     


Ile Tyr Ile Thr Gly Ser Val Pro Ala Leu Gln Asn Trp Ser Pro Asp 
            500                 505                 510         


Asn Ala Leu Ile Leu Ser Ala Ala Asn Tyr Pro Thr Trp Ser Ser Thr 
        515                 520                 525             


Val Asn Leu Pro Ala Ser Thr Thr Ile Glu Tyr Lys Tyr Ile Arg Lys 
    530                 535                 540                 


Phe Asn Gly Ala Val Thr Trp Glu Ser Asp Pro Asn Asn Ser Ile Thr 
545                 550                 555                 560 


Thr Pro Ala Ser Gly Thr Phe Thr Gln Asn Asp Thr Trp Arg 
                565                 570                 


