                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       Hornstein, Eran
       Kredo-Russo, Sharon
 
<120>  DOWNREGULATION OF miR-7 FOR PROMOTION OF BETA CELL 
       DIFFERENTIATION AND INSULIN PRODUCTION

<130>  54344

<150>  US 61/521,411
<151>  2011-08-09

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  1
aacaacctgc ctatgcaacc                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  2
acttggacgg gaactgacac                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  3
cctgttggtg cacttcctac                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  4
tgcagtagtt ctccagctgg                                                   20


<210>  5
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  5
aaaccaagat cactgacaag aaataggt                                          28


<210>  6
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  6
tttgaaattg tacatcccaa gtgac                                             25


<210>  7
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  7
ttcccgaatg gaaccgagc                                                    19


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  8
gtaggcagta cgggtcctct                                                   20


<210>  9
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  9
acctcatccc aggcctatct c                                                 21


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  10
tgaggaggaa gccacaggaa                                                   20


<210>  11
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  11
cagatcggca gcacctttga a                                                 21


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  12
gacccactcc ctggaatgga                                                   20


<210>  13
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  13
tcccatcccc ttactttgat ga                                                22


<210>  14
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  14
gtagcagtat tcgtgtagct gg                                                22


<210>  15
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  15
tggcaaagtg gagattgttg cc                                                22


<210>  16
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  16
aagatggtga tgggcttccc g                                                 21


<210>  17
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  17
ctggttaagc agtacagccc caaa                                              24


<210>  18
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  18
tggcctgtat ccaacacttc gaga                                              24


<210>  19
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Anti-miR-7 antagomir (2'OH)-chl


<220>
<221>  misc_feature
<223>  2-O'-methylated oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate backbone

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate backbone

<220>
<221>  misc_feature
<222>  (20)..(23)
<223>  phosphorothioate backbone

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  (2'OH)-Chol conjugated oligonucleotide

<400>  19
acaacaaaau cacuagucuu cca                                               23


<210>  20
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Anti-miR-122 antagomir (2'OH)-chl


<220>
<221>  misc_feature
<223>  2-O'-methylated oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate backbone

<220>
<221>  misc_feature
<222>  (20)..(23)
<223>  Phosphorothioate backbone

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  (2'OH)-Chol conjugated oligonucleotide

<400>  20
acaaacacca uugucacacu cca                                               23


<210>  21
<211>  110
<212>  RNA
<213>  Homo sapiens

<400>  21
uuggauguug gccuaguucu guguggaaga cuagugauuu uguuguuuuu agauaacuaa       60

aucgacaaca aaucacaguc ugccauaugg cacaggccau gccucuacag                 110


<210>  22
<211>  110
<212>  RNA
<213>  Homo sapiens

<400>  22
cuggauacag aguggaccgg cuggccccau cuggaagacu agugauuuug uuguugucuu       60

acugcgcuca acaacaaauc ccagucuacc uaauggugcc agccaucgca                 110


<210>  23
<211>  110
<212>  RNA
<213>  Homo sapiens

<400>  23
agauuagagu ggcugugguc uagugcugug uggaagacua gugauuuugu uguucugaug       60

uacuacgaca acaagucaca gccggccuca uagcgcagac ucccuucgac                 110


<210>  24
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  24
uggaagacua gugauuuugu ugu                                               23


<210>  25
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  25
caacaaauca cagucugcca ua                                                22


<210>  26
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  26
caacaaaucc cagucuaccu aa                                                22


<210>  27
<211>  23
<212>  RNA
<213>  Mus musculus

<400>  27
aaaauguaag uauuugucuu ccc                                               23


<210>  28
<211>  24
<212>  RNA
<213>  Mus musculus

<400>  28
uggaagacua gugauuuugu uugu                                              24


<210>  29
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  29
caggctccag cttcctga                                                     18


<210>  30
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  30
gtggctgcag tttagctggt                                                   20


<210>  31
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  31
cgtccttcct ccctctagct c                                                 21


<210>  32
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  32
actccctgtc cctgccatg                                                    19


<210>  33
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  33
cagcatttgg caggctct                                                     18


<210>  34
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotides

<400>  34
aggatgttga gctgcgtgag                                                   20


<210>  35
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siPAx6

<400>  35
accaugaucg acaagauuug ccat                                              24


<210>  36
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti Human miR-7-1 pre sequence

<400>  36
tgtgccatat ggcagactgt ga                                                22


<210>  37
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti Human miR-7-1 pre (loop) sequence

<400>  37
tcgatttagt tatctaaaaa c                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti Human miR-7-2 pre sequnece

<400>  38
ggtagactgg gatttgttgt t                                                 21


<210>  39
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti Human miR-7-2 pre (loop) sequence

<400>  39
gagcgcagta agacaacaac aa                                                22


<210>  40
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti Human miR-7-3 pre sequence

<400>  40
gtctgcgcta tgaggccggc t                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Anti Human miR-7-3 pre (loop) sequence

<400>  41
ttgttgtcgt agtacatcag a                                                 21


<210>  42
<211>  5616
<212>  DNA
<213>  Homo sapiens

<400>  42
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg       60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac      120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc      180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga      240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc      300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc      360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt      420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc      480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga      540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc      600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga      660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac      720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg      780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc      840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag      900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca      960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc     1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat     1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat     1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg     1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac     1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac     1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt     1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta     1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat     1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt     1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat     1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa     1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc     1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg     1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag     1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc     1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac     1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga     2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac     2100

ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg     2160

aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg     2220

gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg     2280

ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct     2340

cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg     2400

ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt     2460

aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa     2520

atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg     2580

ggcatctgcc tcacctccac cgtgcagctc atcacgcagc tcatgccctt cggctgcctc     2640

ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt     2700

gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg     2760

gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg     2820

gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc     2880

aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg     2940

agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc     3000

cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata     3060

tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc     3120

ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac     3180

cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac     3240

cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc     3300

ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg     3360

agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt     3420

cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact     3480

gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc     3540

aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg     3600

cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat     3660

ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc     3720

cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc     3780

aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta     3840

agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc     3900

ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac     3960

agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta     4020

gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac     4080

tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat     4140

ctttcaaaga ggtatatttg aaaaaaaaaa aaagtatatg tgaggatttt tattgattgg     4200

ggatcttgga gtttttcatt gtcgctattg atttttactt caatgggctc ttccaacaag     4260

gaagaagctt gctggtagca cttgctaccc tgagttcatc caggcccaac tgtgagcaag     4320

gagcacaagc cacaagtctt ccagaggatg cttgattcca gtggttctgc ttcaaggctt     4380

ccactgcaaa acactaaaga tccaagaagg ccttcatggc cccagcaggc cggatcggta     4440

ctgtatcaag tcatggcagg tacagtagga taagccactc tgtcccttcc tgggcaaaga     4500

agaaacggag gggatggaat tcttccttag acttactttt gtaaaaatgt ccccacggta     4560

cttactcccc actgatggac cagtggtttc cagtcatgag cgttagactg acttgtttgt     4620

cttccattcc attgttttga aactcagtat gctgcccctg tcttgctgtc atgaaatcag     4680

caagagagga tgacacatca aataataact cggattccag cccacattgg attcatcagc     4740

atttggacca atagcccaca gctgagaatg tggaatacct aaggatagca ccgcttttgt     4800

tctcgcaaaa acgtatctcc taatttgagg ctcagatgaa atgcatcagg tcctttgggg     4860

catagatcag aagactacaa aaatgaagct gctctgaaat ctcctttagc catcacccca     4920

accccccaaa attagtttgt gttacttatg gaagatagtt ttctcctttt acttcacttc     4980

aaaagctttt tactcaaaga gtatatgttc cctccaggtc agctgccccc aaaccccctc     5040

cttacgcttt gtcacacaaa aagtgtctct gccttgagtc atctattcaa gcacttacag     5100

ctctggccac aacagggcat tttacaggtg cgaatgacag tagcattatg agtagtgtgg     5160

aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc     5220

agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg     5280

gaagattcag ctagttagga gcccaccttt tttcctaatc tgtgtgtgcc ctgtaacctg     5340

actggttaac agcagtcctt tgtaaacagt gttttaaact ctcctagtca atatccaccc     5400

catccaattt atcaaggaag aaatggttca gaaaatattt tcagcctaca gttatgttca     5460

gtcacacaca catacaaaat gttccttttg cttttaaagt aatttttgac tcccagatca     5520

gtcagagccc ctacagcatt gttaagaaag tatttgattt ttgtctcaat gaaaataaaa     5580

ctatattcat ttccactcta aaaaaaaaaa aaaaaa                               5616


<210>  43
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  44
<211>  4480
<212>  DNA
<213>  Homo sapiens

<400>  44
agttgtaact gtagtaggtc agtgatacat ggtgcaaaac agcctgggat aatattgcca       60

gctgccagac cagactaggg tggctcaagg ggttgccata gtttctaaat cttttgaagg      120

aaaaactgat cgcacagaag agtggtatgg aacccagtac aaacaagaag ctataccgga      180

tgaagtcatc aagaaatggc aaaatgctga cctgaatggg aaatttaaac ttcctacaaa      240

gaatgaattt attcctacga attttgagat tttaccgtta gaaaaagagg cgacaccata      300

ccctgctctt attaaggata cagctatgag caaactttgg ttcaaacaag atgataagtt      360

ttttttgccg aaggcttgtc tcaactttga atttttcagc ccatttgctt atgtggaccc      420

cttgcactgt aacatggcct atttgtacct tgagctcctc aaagactcac tcaacgagta      480

tgcatatgca gcagagctag caggcttgag ctatgatctc caaaatacca tctatgggat      540

gtatctttca gtgaaaggtt acaatgacaa gcagccaatt ttactaaaga agattattga      600

gaaaatggct acctttgaga ttgatgaaaa aagatttgaa attatcaaag aagcatatat      660

gcgatctctt aacaatttcc gggctgaaca gcctcaccag catgccatgt actacctccg      720

cttgctgatg actgaagtgg cctggactaa agatgagtta aaagaagctc tggatgatgt      780

aacccttcct cgccttaagg ccttcatacc tcagctcctg tcacggctgc acattgaagc      840

ccttctccat ggaaacataa caaagcaggc tgcattagga attatgcaga tggttgaaga      900

caccctcatt gaacatgctc ataccaaacc tctccttcca agtcagctgg ttcggtatag      960

agaagttcag ctccctgaca gaggatggtt tgtttatcag cagagaaatg aagttcacaa     1020

taactgtggc atcgagatat actaccaaac agacatgcaa agcacctcag agaatatgtt     1080

tctggagctc ttctgtcaga ttatctcgga accttgcttc aacaccctgc gcaccaagga     1140

gcagttgggc tatatcgtct tcagcgggcc acgtcgagct aatggcatac agggcttgag     1200

attcatcatc cagtcagaaa agccacctca ctacctagaa agcagagtgg aagctttctt     1260

aattaccatg gaaaagtcca tagaggacat gacagaagag gccttccaaa aacacattca     1320

ggcattagca attcgtcgac tagacaaacc aaagaagcta tctgctgagt gtgctaaata     1380

ctggggagaa atcatctccc agcaatataa ttttgacaga gataacactg aggttgcata     1440

tttaaagaca cttaccaagg aagatatcat caaattctac aaggaaatgt tggcagtaga     1500

tgctccaagg agacataagg tatccgtcca tgttcttgcc agggaaatgg attcttgtcc     1560

tgttgttgga gagttcccat gtcaaaatga cataaatttg tcacaagcac cagccttgcc     1620

acaacctgaa gtgattcaga acatgaccga attcaagcgt ggtctgccac tgtttcccct     1680

tgtgaaacca catattaact tcatggctgc aaaactctga agattcccca tgcatgggaa     1740

agtgcaagtg gatgcattcc tgagtcttcc agagcctaag aaaatcatct tggccacttt     1800

aatagtttct gattcactat tagagaaaca aacaaaaaat tgtcaaatgt cattatgtag     1860

aaatattata aatccaaagt aaattacaaa atcttataga tgtagaatat tttttaaata     1920

catgcctctt aaatatttta aaatttttct tttgattact gagagaaatt tccccaatat     1980

aacaatgctt aaaatgaatg atattcctat agaatcttcc ttccctattc tgtaaaatag     2040

tcacttgtcc gaagaaagtt aaaagttagc tcttttctaa aagcctccta gcttgacata     2100

gaaggcttca caacatttag aaaggtaata actttttaaa aattgatcct caaatttgct     2160

ttctacttga tggtttcatg taaatcagtg gaaaacatta catttggcag atgataaagc     2220

aatgtcatct tttattagtg aaatgctggt tatataaggc atggttttaa tctttttata     2280

aaatttgaac atgtttttta tgccaactcg taaaatgcta gaaaacccta cttatttaca     2340

atgctagaaa tacagactta ccttacatca attttgtcct aaaccgaatt tctcaggatt     2400

actgtggttt ctttcattct gattgaatta tattgaccta cttcttcata gttggtttgc     2460

agtgttccat gagttttact tttcctcatc aacatattgc tttaacacaa catatttatt     2520

taacacgtac aaatagggtc aacttcagat cctactgagt gtgtgacatg cttttccaac     2580

atcagctttt tgtaaccacc tgtataactt tttattacag tgaaattgca gtcagtatgt     2640

gaaccaaaat atcttgcccc tttatgaatt taaaaggcag ccaatacaaa gccacctttt     2700

tggaaatata aaaagtaaag ccttgcattc ttatatagca ggtcttcata aaactctaaa     2760

atcccttgtt gctaccagtc taatcttgcc ttaaatgtta agttattttt tgaatatata     2820

aatataaaca tataaacaca gatgatgact ggagtagact tttaaaaaaa tatttttttc     2880

atgagatact attttaggtg aaattgttac tgtagattta acagctgttt tgaaatattt     2940

actgttatta aaacttgctt caagagaaat tgtgaatata tttccatata caagcactag     3000

taacagtaag tggccctgtc atccactaac tcaggcaaag taaagaatgg catttttgaa     3060

ggacatttta cctccccata tgatttgatt ggctaggact ttcttctgta aagtcatacc     3120

ttttcacatc ttaagttttt acatttgcca ttttccaaat ctcaattttg ggcaagaacg     3180

atatagtcac aactatgggg ctgctttcaa aagcggggct ccatttctac tgtcagatca     3240

atgtggtgct gtaaccatct ttttatccct accttcaaga acctccttat atgaagcctg     3300

tctttatcca tcagaaggtg tgtgaaatca tcacttcctt ctggttttat gtatttgtag     3360

actatgcagc ttttcattaa actgcaagta tatacaagac agatctgaaa ttaggcctga     3420

gtgttccgat ccaccactgt actagtaaat aaaaatccac ctacctttta tgtggaaaat     3480

tatgtgctat tgagtaactt ttagctcttt tttaaaaaat gggtgaaatt taagtgtctt     3540

ttttatgaga atgacacatg aagagatctg agagcaatct catgtagtct tccatgaacc     3600

tgcaattgtt tggtatgcgt cagcattttc caatttccag gttggatcta gagctgctgt     3660

tgatcactca ggcatactaa tggattcatt tagatgggtc caagctgcag tccatgagca     3720

ataacagact accccagata ctgcagttta cgcagtgctt agtaaatgag atttgtggaa     3780

ctaagttatt agttacctga ggcttcttaa gaaagtcttc ttttttgacc agttgatgtg     3840

aaagagggag catgtgacac agccagtatg gtggagtgct agggttatcc tgtttacaat     3900

aaatcgcctg aatttcacct ctggagtctg catttgtatt atttttccag ttttagtgaa     3960

atagtacagt ggccagtcct cagcctacct ctcaacatcc cagtttgacc agatttcttg     4020

ctttcattgt tcataatgca gaaagcagtg aattatatta acattttaaa agtgtttctg     4080

ggtaacaatg atttttgtca aatagaagac tcaatttcac aaccttaaga atagatcact     4140

tttgtaaaac aagaatctca gtatttgatg ttggactcct tgctgtgagt attgtcactg     4200

actccaaacc cagaaagatt tgttcctgcc cttacaggga tgaaaataaa aaggatagaa     4260

aaaatatttc tctcctctac aatgagtcct tacatcttct tgccacatct ccagctgcag     4320

tttaggcaga tatcttgttc aatctctgtc ttcttgatcc ctgtcaaaat aatttttcta     4380

ctcatatagt ggccagttgg ctcaggcagg catttcaaga ggaatctgct tgttcctcac     4440

ttttccagca taggacagtg gtccagcccg cacagtcagc                           4480


<210>  45
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ser Lys Leu Trp Phe Lys Gln Asp Asp Lys Phe Phe Leu Pro Lys 
1               5                   10                  15      


Ala Cys Leu Asn Phe Glu Phe Phe Ser Pro Phe Ala Tyr Val Asp Pro 
            20                  25                  30          


Leu His Cys Asn Met Ala Tyr Leu Tyr Leu Glu Leu Leu Lys Asp Ser 
        35                  40                  45              


Leu Asn Glu Tyr Ala Tyr Ala Ala Glu Leu Ala Gly Leu Ser Tyr Asp 
    50                  55                  60                  


Leu Gln Asn Thr Ile Tyr Gly Met Tyr Leu Ser Val Lys Gly Tyr Asn 
65                  70                  75                  80  


Asp Lys Gln Pro Ile Leu Leu Lys Lys Ile Ile Glu Lys Met Ala Thr 
                85                  90                  95      


Phe Glu Ile Asp Glu Lys Arg Phe Glu Ile Ile Lys Glu Ala Tyr Met 
            100                 105                 110         


Arg Ser Leu Asn Asn Phe Arg Ala Glu Gln Pro His Gln His Ala Met 
        115                 120                 125             


Tyr Tyr Leu Arg Leu Leu Met Thr Glu Val Ala Trp Thr Lys Asp Glu 
    130                 135                 140                 


Leu Lys Glu Ala Leu Asp Asp Val Thr Leu Pro Arg Leu Lys Ala Phe 
145                 150                 155                 160 


Ile Pro Gln Leu Leu Ser Arg Leu His Ile Glu Ala Leu Leu His Gly 
                165                 170                 175     


Asn Ile Thr Lys Gln Ala Ala Leu Gly Ile Met Gln Met Val Glu Asp 
            180                 185                 190         


Thr Leu Ile Glu His Ala His Thr Lys Pro Leu Leu Pro Ser Gln Leu 
        195                 200                 205             


Val Arg Tyr Arg Glu Val Gln Leu Pro Asp Arg Gly Trp Phe Val Tyr 
    210                 215                 220                 


Gln Gln Arg Asn Glu Val His Asn Asn Cys Gly Ile Glu Ile Tyr Tyr 
225                 230                 235                 240 


Gln Thr Asp Met Gln Ser Thr Ser Glu Asn Met Phe Leu Glu Leu Phe 
                245                 250                 255     


Cys Gln Ile Ile Ser Glu Pro Cys Phe Asn Thr Leu Arg Thr Lys Glu 
            260                 265                 270         


Gln Leu Gly Tyr Ile Val Phe Ser Gly Pro Arg Arg Ala Asn Gly Ile 
        275                 280                 285             


Gln Gly Leu Arg Phe Ile Ile Gln Ser Glu Lys Pro Pro His Tyr Leu 
    290                 295                 300                 


Glu Ser Arg Val Glu Ala Phe Leu Ile Thr Met Glu Lys Ser Ile Glu 
305                 310                 315                 320 


Asp Met Thr Glu Glu Ala Phe Gln Lys His Ile Gln Ala Leu Ala Ile 
                325                 330                 335     


Arg Arg Leu Asp Lys Pro Lys Lys Leu Ser Ala Glu Cys Ala Lys Tyr 
            340                 345                 350         


Trp Gly Glu Ile Ile Ser Gln Gln Tyr Asn Phe Asp Arg Asp Asn Thr 
        355                 360                 365             


Glu Val Ala Tyr Leu Lys Thr Leu Thr Lys Glu Asp Ile Ile Lys Phe 
    370                 375                 380                 


Tyr Lys Glu Met Leu Ala Val Asp Ala Pro Arg Arg His Lys Val Ser 
385                 390                 395                 400 


Val His Val Leu Ala Arg Glu Met Asp Ser Cys Pro Val Val Gly Glu 
                405                 410                 415     


Phe Pro Cys Gln Asn Asp Ile Asn Leu Ser Gln Ala Pro Ala Leu Pro 
            420                 425                 430         


Gln Pro Glu Val Ile Gln Asn Met Thr Glu Phe Lys Arg Gly Leu Pro 
        435                 440                 445             


Leu Phe Pro Leu Val Lys Pro His Ile Asn Phe Met Ala Ala Lys Leu 
    450                 455                 460                 


<210>  46
<211>  7014
<212>  DNA
<213>  Homo sapiens

<400>  46
cggggaccgc gacgagcccg ggtcgccgtt ggcagcagca gcagcaacac cagcagcagc       60

agcagccccg gcggcggcgc ggaccccgag cgcccgggcg caccccggct tcccggagcg      120

cgacgcggcg gcagcagccc cggtgcggcc gcgcgcgcct taggctcggc cccgcggctc      180

ggggaccccg actcccggcc cagcgagcgc gtcccccggc gccgcccgag agcccgagga      240

ggcagcggcc gcaggcagcc ggggaggggg gcggccaccg cccgcgccgg gcatcctcag      300

gagccccaga gcgcggaggg cgcggcgccg ccgagcggtg ctggcccccg cgggcctccc      360

cggaccttcc ccaccgcctg ggcccgaggg acgcgtgatc gggcgggcgg ccgggcgcaa      420

gggtgggagg gagccgcccc cgcccgcgcc ccctccgccc ctcgccccaa cccctgggcg      480

ccgggcccgg gccgcgcggc ctgaagcgcc cgcgatggcg agcccgccgc ggcacgggcc      540

gcccgggccg gcgagcggag acggccccaa cctcaacaac aacaacaaca acaacaacca      600

cagcgtgcgc aagtgcggct acctgcgcaa gcagaagcat ggccacaagc gcttcttcgt      660

gctgcgcgga cccggcgcgg gcggcgacga ggcgacggcg ggcggggggt cggcgccgca      720

accgccgcgg ctcgagtact acgagagcga gaaaaagtgg cggagcaagg caggcgcgcc      780

gaaacgggtg atcgctctcg actgctgcct gaacatcaac aagcgcgccg acgccaagca      840

caagtacctg atcgccctct acaccaagga cgagtacttc gccgtggccg ccgagaacga      900

gcaggagcag gagggctggt accgcgcgct caccgacctg gtcagcgagg gccgcgcggc      960

cgccggagac gcgccccccg ccgccgcgcc cgccgcgtcc tgcagcgcct ccctgcccgg     1020

cgccctgggc ggctctgccg gcgccgccgg ggccgaggac agctacgggc tggtggctcc     1080

cgccacggcc gcctaccgtg aggtgtggca ggtgaacctg aagcccaagg gtctgggcca     1140

gagcaagaac ctgacggggg tgtaccgtct gtgcctgtct gcgcgcacca tcggcttcgt     1200

gaagctcaac tgcgagcagc cgtcggtgac gctgcagctc atgaacatcc gccgctgcgg     1260

ccactcggac agcttcttct tcatcgaggt gggccgctcg gccgtcacag gccccggcga     1320

gctgtggatg caggcggacg actcggtggt ggcgcagaac atccacgaga ccatcctgga     1380

ggccatgaag gcgctcaagg agctcttcga gttccggccg cgcagtaaga gccaatcgtc     1440

ggggtcgtcg gccacgcacc ccatcagcgt ccccggcgcg cgccgccacc accacctggt     1500

caacctgccc cccagccaga cgggcctggt gcgccgctcg cgcaccgaca gcctggccgc     1560

caccccgccg gcggccaagt gcagctcgtg ccgggtgcgc accgccagcg agggcgacgg     1620

cggcgcggcg gcgggagcgg cggccgcggg cgccaggccg gtgtcggtgg ctgggagccc     1680

cctgagcccc gggccggtgc gcgcgcccct gagccgctcg cacaccctga gcggcggctg     1740

cggcggccgc gggagcaagg tggcgctgct gccggcaggg ggcgcgctgc aacacagccg     1800

ctccatgtcc atgcccgtgg cgcactcgcc gcccgccgcc accagccccg gctccctgtc     1860

gtccagcagc ggccacggct cgggctccta cccgccgccg cccggcccgc acccgcctct     1920

gccgcatccg ctgcaccacg gccccggcca gcggccctcc agcggcagcg cctccgcctc     1980

gggctccccc agcgaccccg gcttcatgtc cctggacgag tacggctcca gcccaggcga     2040

cctgcgcgcc ttctgcagcc accgaagcaa cacgcccgag tccatcgcgg agacgccccc     2100

ggcccgagac ggcggcggcg gcggtgagtt ctacgggtac atgaccatgg acaggcccct     2160

gagccactgt ggccgctcct accgccgggt ctcgggggac gcggcccagg acctggaccg     2220

agggctgcgc aagaggacct actccctgac cacgccagcc cggcagcggc cggtgcccca     2280

gccctcctct gcctcgctgg atgaatacac cctgatgcgg gccaccttct cgggcagcgc     2340

gggccgcctc tgcccgtcct gccccgcgtc ctctcccaag gtggcctacc acccctaccc     2400

agaggactac ggagacatcg agatcggctc ccacaggagc tccagcagca acctgggggc     2460

agacgacggc tacatgccca tgacgcccgg cgcggccctc gcgggcagtg ggagcggcag     2520

ctgcaggagc gacgactaca tgcccatgag ccccgccagc gtgtccgccc ccaagcagat     2580

cttgcagccc agggccgccg ccgccgccgc cgccgccgtg ccttctgcgg ggcctgcggg     2640

gccagcaccc acctctgcgg cgggcaggac attcccggcg agcgggggcg gctacaaggc     2700

cagctcgccc gccgagagct cccccgagga cagtgggtac atgcgcatgt ggtgcggttc     2760

caagctgtcc atggagcatg cagatggcaa gctgctgccc aacggggact acctcaacgt     2820

gtcccccagc gacgcggtca ccacgggcac cccgcccgac ttcttctccg cagccctgca     2880

ccccggcggg gagccgctca ggggcgttcc cggctgctgc tacagctcct tgccccgctc     2940

ctacaaggcc ccctacacct gtggcgggga cagcgaccag tacgtgctca tgagctcccc     3000

cgtggggcgc atcctggagg aggagcgtct ggagcctcag gccacgccag ggcccagcca     3060

ggcggccagc gccttcgggg ccggccccac gcagccccct caccctgtag tgccttcgcc     3120

cgtgcggcct agcggcggcc gcccggaggg cttcttgggc cagcgcggcc gggcggtgag     3180

gcccacgcgc ctgtccctgg aggggctgcc cagcctgccc agcatgcacg agtacccact     3240

gccaccggag cccaagagcc ccggcgagta catcaacatc gactttggcg agcccggggc     3300

ccgcctgtcg ccgcccgcgc ctcccctgct ggcgtcggcg gcctcgtcct cctcgctctt     3360

gtccgccagc agcccggcct cgtcgctggg ctcaggcacc ccgggcacca gcagcgacag     3420

ccggcagcgg tctccgctct ccgactacat gaacctcgac ttcagctccc ccaagtctcc     3480

taagccgggc gccccgagcg gccaccccgt gggctccttg gacggcctcc tgtcccccga     3540

ggcctcctcc ccgtatccgc cgttgccccc gcgtccgtcc gcgtccccgt cgtcgtctct     3600

gcagccgccg ccaccgccgc cggccccggg ggagctgtac cgcctgcccc ccgcctcggc     3660

cgttgccacc gcccagggcc cgggcgccgc ctcatcgttg tcctcggaca ccggggacaa     3720

tggtgactac accgagatgg cttttggtgt ggccgccacc ccgccgcaac ctatcgcggc     3780

ccccccgaag ccagaagctg cccgcgtggc cagcccgacg tcgggcgtga agaggctgag     3840

cctcatggag caggtgtcgg gagtcgaggc cttcctgcag gccagccagc ccccggaccc     3900

ccaccgcggc gccaaggtca tccgcgcaga cccgcagggg ggccgccgcc gccacagttc     3960

cgagaccttc tcctccacca cgacggtcac ccccgtgtcc ccgtccttcg cccacaaccc     4020

caagcgccac aactcggcct ccgtggaaaa tgtctctctc aggaaaagca gcgagggcgg     4080

cgtgggtgtc ggccctggag ggggcgacga gccgcccacc tccccacgac agttgcagcc     4140

ggcgccccct ttggcaccgc agggccggcc gtggaccccg ggtcagcccg ggggcttggt     4200

cggttgtcct gggagcggtg gatcgcccat gcgcagagag acctctgccg gcttccagaa     4260

tggtctcaac tacatcgcca tcgacgtgag ggaggagccc gggctgccac cccagccgca     4320

gccgccgccg ccgccgcttc ctcagccggg agacaagagc tcctggggcc ggacccgaag     4380

cctcgggggt ctcatcagcg ctgtgggcgt cggcagcacc ggcggcgggt gcggggggcc     4440

gggtcccggt gccctgcccc ctgccaacac ctacgccagc attgacttct tgtcccacca     4500

cttgaaggag gccaccatcg tgaaagagtg aagatctgtc tggctttatc accaggatgt     4560

cacatgtcag agagtatcat taaaagaaga cgctcagcac tgtttcagcc cgaagctgct     4620

tgcagttttc ttttggatct gagcaatgac tgtgtttgga aacatctgtg gactctgtta     4680

gatgaggcac caacaaggca aggtcacctg cctctttccc ttgttcccgg atggggcatt     4740

catcattgtg ctgtttgcgt tttgttttgt tttgttttaa caaaattagc tgaagaagtt     4800

attctcaaga aaattggatg ttttcattgg ccttcttaaa ttgtggccag tgtcttttaa     4860

tttcttcttc ttttcctttt ggcaaagcag atataaccct cagcatgcta ggagagtgca     4920

cccgtaccta tggaagtggt aaaatctggt atttactggc ttacactcaa aacgaccaca     4980

gtcctacctc agttcaaggt aaagccggat ttccgtggcg ggggtcccac aggacctcct     5040

gtagtagccc ctgcgctgtg tgtctggagc gcggtcctcg gccttattga aatggtccaa     5100

gtagacagct gcttgttgga ttccagtgca ggtacctgcg atgtttacgt ccacaccgag     5160

cccagtgtgg gactgacatt tctcaatgga agtgaaattt gggattggac tttgaagacg     5220

gattactaaa taataattat tatatgtaac tgaagcaacc tacttttgaa aatcaactgt     5280

attgggtagt gggaggtggg agggaagggc tttgggaagg ggatgaatat ctctttttac     5340

ctttaacaga cttgtttaat cttctcgatg tagatgttta tgtaggtact tcacattgca     5400

aacgcctttt attctattta caagctcaga tgtctctgct ctcctgaatc ttgggcatgc     5460

ctttctgtaa ccaaaaatcc ctgtaggcgt gctagcaatt ccagggtggt ccgggtttgg     5520

cagatttgat ttttaaaaaa cgtattatct ttaataaaat gttattatgt caaccagtga     5580

ggctgccctg aacaaaaaaa acaaaaagaa aaaaaaaaaa ggaaagaaag aaactgataa     5640

aaagaggcat tccagcccct atgttattga tggaaaaaga aaaagaagaa aagcaatctc     5700

gcagtacatg ttacttgtcg aaaaaattcc ggacaagact acccttgttt tatgttttca     5760

gtattctgaa aataccagtg tgtggcagtt ctcgcagatg ttacctaaaa ctgctgaact     5820

tgaccggcag aatgttctgc cgttttctgc tccctcgaca cttgattgga gggctgtcga     5880

cctctcctcc cgtgggggct tccccagtgc ctatcttctc tgatagtcat ggagaggtta     5940

cactaattca ttggagatgt aagttgttgg ttttgttttg ttttgttttt agaaaaatat     6000

atataaatat ataatagata tctatcgcta tagaataatg cattaataaa atgaggcttt     6060

tttagaggaa gaccaaaaaa ttcaatgtct taaaaatata tttaatggca atgcaaaagt     6120

cttcctgctt ccgtgctgaa ctttagaaca gaggattgta ttgcaagaca aagttgaatg     6180

taaagtgatc tccctgaaca tttttaaggt tttacttttc tgaaattata catcacagca     6240

gtgcataggc catataatgt tagctggaag gtcaatttca gtgtatgata tactttatta     6300

agatgtataa aaatcctgaa gtttttattt agttttggga ataggcatca atgggtggta     6360

tttgctttgt aactcccccc aggtacgata gggactgaat atggaccctg ctgaaagcag     6420

tgtattgacg catatttaac tcgccctcta tccgtagagt agtcatgaca ctatacagat     6480

ggttcgtgtt catactgcag cttaaaacaa gcaaaataca cagatgataa tatgctaaat     6540

tttcctctat cctgtacatt tcacaaaaag gcatatgcaa tatttacatt tttaatttag     6600

tttacagaat ggaaccaaaa tgtataaatg ttatgtttgc taaaacttca caatgtatat     6660

tgggtctttg tacattttgc ctgacttacc ttaaatttaa aatatttttt gctatataaa     6720

ctttaacagt tattaaacag tgttttcttt ttgggtacgt attgtttctg gatatcaaga     6780

tgttaaatat atttcttgct attgtgatat gacaagagac ttaacttatc ttgctctgtc     6840

ttccactgta cacgctgtat ataggggtca atgtgatgct gctggagacg agaataaact     6900

ggactagaat agtgcattgt atttagtctg tattgatcat ggatgccctc cttaatagcc     6960

atatgcaata aaataaagta cattatttat gaaatgaaaa aaaaaaaaaa aaaa           7014


<210>  47
<211>  1338
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Ser Pro Pro Arg His Gly Pro Pro Gly Pro Ala Ser Gly Asp 
1               5                   10                  15      


Gly Pro Asn Leu Asn Asn Asn Asn Asn Asn Asn Asn His Ser Val Arg 
            20                  25                  30          


Lys Cys Gly Tyr Leu Arg Lys Gln Lys His Gly His Lys Arg Phe Phe 
        35                  40                  45              


Val Leu Arg Gly Pro Gly Ala Gly Gly Asp Glu Ala Thr Ala Gly Gly 
    50                  55                  60                  


Gly Ser Ala Pro Gln Pro Pro Arg Leu Glu Tyr Tyr Glu Ser Glu Lys 
65                  70                  75                  80  


Lys Trp Arg Ser Lys Ala Gly Ala Pro Lys Arg Val Ile Ala Leu Asp 
                85                  90                  95      


Cys Cys Leu Asn Ile Asn Lys Arg Ala Asp Ala Lys His Lys Tyr Leu 
            100                 105                 110         


Ile Ala Leu Tyr Thr Lys Asp Glu Tyr Phe Ala Val Ala Ala Glu Asn 
        115                 120                 125             


Glu Gln Glu Gln Glu Gly Trp Tyr Arg Ala Leu Thr Asp Leu Val Ser 
    130                 135                 140                 


Glu Gly Arg Ala Ala Ala Gly Asp Ala Pro Pro Ala Ala Ala Pro Ala 
145                 150                 155                 160 


Ala Ser Cys Ser Ala Ser Leu Pro Gly Ala Leu Gly Gly Ser Ala Gly 
                165                 170                 175     


Ala Ala Gly Ala Glu Asp Ser Tyr Gly Leu Val Ala Pro Ala Thr Ala 
            180                 185                 190         


Ala Tyr Arg Glu Val Trp Gln Val Asn Leu Lys Pro Lys Gly Leu Gly 
        195                 200                 205             


Gln Ser Lys Asn Leu Thr Gly Val Tyr Arg Leu Cys Leu Ser Ala Arg 
    210                 215                 220                 


Thr Ile Gly Phe Val Lys Leu Asn Cys Glu Gln Pro Ser Val Thr Leu 
225                 230                 235                 240 


Gln Leu Met Asn Ile Arg Arg Cys Gly His Ser Asp Ser Phe Phe Phe 
                245                 250                 255     


Ile Glu Val Gly Arg Ser Ala Val Thr Gly Pro Gly Glu Leu Trp Met 
            260                 265                 270         


Gln Ala Asp Asp Ser Val Val Ala Gln Asn Ile His Glu Thr Ile Leu 
        275                 280                 285             


Glu Ala Met Lys Ala Leu Lys Glu Leu Phe Glu Phe Arg Pro Arg Ser 
    290                 295                 300                 


Lys Ser Gln Ser Ser Gly Ser Ser Ala Thr His Pro Ile Ser Val Pro 
305                 310                 315                 320 


Gly Ala Arg Arg His His His Leu Val Asn Leu Pro Pro Ser Gln Thr 
                325                 330                 335     


Gly Leu Val Arg Arg Ser Arg Thr Asp Ser Leu Ala Ala Thr Pro Pro 
            340                 345                 350         


Ala Ala Lys Cys Ser Ser Cys Arg Val Arg Thr Ala Ser Glu Gly Asp 
        355                 360                 365             


Gly Gly Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala Arg Pro Val Ser 
    370                 375                 380                 


Val Ala Gly Ser Pro Leu Ser Pro Gly Pro Val Arg Ala Pro Leu Ser 
385                 390                 395                 400 


Arg Ser His Thr Leu Ser Gly Gly Cys Gly Gly Arg Gly Ser Lys Val 
                405                 410                 415     


Ala Leu Leu Pro Ala Gly Gly Ala Leu Gln His Ser Arg Ser Met Ser 
            420                 425                 430         


Met Pro Val Ala His Ser Pro Pro Ala Ala Thr Ser Pro Gly Ser Leu 
        435                 440                 445             


Ser Ser Ser Ser Gly His Gly Ser Gly Ser Tyr Pro Pro Pro Pro Gly 
    450                 455                 460                 


Pro His Pro Pro Leu Pro His Pro Leu His His Gly Pro Gly Gln Arg 
465                 470                 475                 480 


Pro Ser Ser Gly Ser Ala Ser Ala Ser Gly Ser Pro Ser Asp Pro Gly 
                485                 490                 495     


Phe Met Ser Leu Asp Glu Tyr Gly Ser Ser Pro Gly Asp Leu Arg Ala 
            500                 505                 510         


Phe Cys Ser His Arg Ser Asn Thr Pro Glu Ser Ile Ala Glu Thr Pro 
        515                 520                 525             


Pro Ala Arg Asp Gly Gly Gly Gly Gly Glu Phe Tyr Gly Tyr Met Thr 
    530                 535                 540                 


Met Asp Arg Pro Leu Ser His Cys Gly Arg Ser Tyr Arg Arg Val Ser 
545                 550                 555                 560 


Gly Asp Ala Ala Gln Asp Leu Asp Arg Gly Leu Arg Lys Arg Thr Tyr 
                565                 570                 575     


Ser Leu Thr Thr Pro Ala Arg Gln Arg Pro Val Pro Gln Pro Ser Ser 
            580                 585                 590         


Ala Ser Leu Asp Glu Tyr Thr Leu Met Arg Ala Thr Phe Ser Gly Ser 
        595                 600                 605             


Ala Gly Arg Leu Cys Pro Ser Cys Pro Ala Ser Ser Pro Lys Val Ala 
    610                 615                 620                 


Tyr His Pro Tyr Pro Glu Asp Tyr Gly Asp Ile Glu Ile Gly Ser His 
625                 630                 635                 640 


Arg Ser Ser Ser Ser Asn Leu Gly Ala Asp Asp Gly Tyr Met Pro Met 
                645                 650                 655     


Thr Pro Gly Ala Ala Leu Ala Gly Ser Gly Ser Gly Ser Cys Arg Ser 
            660                 665                 670         


Asp Asp Tyr Met Pro Met Ser Pro Ala Ser Val Ser Ala Pro Lys Gln 
        675                 680                 685             


Ile Leu Gln Pro Arg Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Ser 
    690                 695                 700                 


Ala Gly Pro Ala Gly Pro Ala Pro Thr Ser Ala Ala Gly Arg Thr Phe 
705                 710                 715                 720 


Pro Ala Ser Gly Gly Gly Tyr Lys Ala Ser Ser Pro Ala Glu Ser Ser 
                725                 730                 735     


Pro Glu Asp Ser Gly Tyr Met Arg Met Trp Cys Gly Ser Lys Leu Ser 
            740                 745                 750         


Met Glu His Ala Asp Gly Lys Leu Leu Pro Asn Gly Asp Tyr Leu Asn 
        755                 760                 765             


Val Ser Pro Ser Asp Ala Val Thr Thr Gly Thr Pro Pro Asp Phe Phe 
    770                 775                 780                 


Ser Ala Ala Leu His Pro Gly Gly Glu Pro Leu Arg Gly Val Pro Gly 
785                 790                 795                 800 


Cys Cys Tyr Ser Ser Leu Pro Arg Ser Tyr Lys Ala Pro Tyr Thr Cys 
                805                 810                 815     


Gly Gly Asp Ser Asp Gln Tyr Val Leu Met Ser Ser Pro Val Gly Arg 
            820                 825                 830         


Ile Leu Glu Glu Glu Arg Leu Glu Pro Gln Ala Thr Pro Gly Pro Ser 
        835                 840                 845             


Gln Ala Ala Ser Ala Phe Gly Ala Gly Pro Thr Gln Pro Pro His Pro 
    850                 855                 860                 


Val Val Pro Ser Pro Val Arg Pro Ser Gly Gly Arg Pro Glu Gly Phe 
865                 870                 875                 880 


Leu Gly Gln Arg Gly Arg Ala Val Arg Pro Thr Arg Leu Ser Leu Glu 
                885                 890                 895     


Gly Leu Pro Ser Leu Pro Ser Met His Glu Tyr Pro Leu Pro Pro Glu 
            900                 905                 910         


Pro Lys Ser Pro Gly Glu Tyr Ile Asn Ile Asp Phe Gly Glu Pro Gly 
        915                 920                 925             


Ala Arg Leu Ser Pro Pro Ala Pro Pro Leu Leu Ala Ser Ala Ala Ser 
    930                 935                 940                 


Ser Ser Ser Leu Leu Ser Ala Ser Ser Pro Ala Ser Ser Leu Gly Ser 
945                 950                 955                 960 


Gly Thr Pro Gly Thr Ser Ser Asp Ser Arg Gln Arg Ser Pro Leu Ser 
                965                 970                 975     


Asp Tyr Met Asn Leu Asp Phe Ser Ser Pro Lys Ser Pro Lys Pro Gly 
            980                 985                 990         


Ala Pro Ser Gly His Pro Val Gly  Ser Leu Asp Gly Leu  Leu Ser Pro 
        995                 1000                 1005             


Glu Ala  Ser Ser Pro Tyr Pro  Pro Leu Pro Pro Arg  Pro Ser Ala 
    1010                 1015                 1020             


Ser Pro  Ser Ser Ser Leu Gln  Pro Pro Pro Pro Pro  Pro Ala Pro 
    1025                 1030                 1035             


Gly Glu  Leu Tyr Arg Leu Pro  Pro Ala Ser Ala Val  Ala Thr Ala 
    1040                 1045                 1050             


Gln Gly  Pro Gly Ala Ala Ser  Ser Leu Ser Ser Asp  Thr Gly Asp 
    1055                 1060                 1065             


Asn Gly  Asp Tyr Thr Glu Met  Ala Phe Gly Val Ala  Ala Thr Pro 
    1070                 1075                 1080             


Pro Gln  Pro Ile Ala Ala Pro  Pro Lys Pro Glu Ala  Ala Arg Val 
    1085                 1090                 1095             


Ala Ser  Pro Thr Ser Gly Val  Lys Arg Leu Ser Leu  Met Glu Gln 
    1100                 1105                 1110             


Val Ser  Gly Val Glu Ala Phe  Leu Gln Ala Ser Gln  Pro Pro Asp 
    1115                 1120                 1125             


Pro His  Arg Gly Ala Lys Val  Ile Arg Ala Asp Pro  Gln Gly Gly 
    1130                 1135                 1140             


Arg Arg  Arg His Ser Ser Glu  Thr Phe Ser Ser Thr  Thr Thr Val 
    1145                 1150                 1155             


Thr Pro  Val Ser Pro Ser Phe  Ala His Asn Pro Lys  Arg His Asn 
    1160                 1165                 1170             


Ser Ala  Ser Val Glu Asn Val  Ser Leu Arg Lys Ser  Ser Glu Gly 
    1175                 1180                 1185             


Gly Val  Gly Val Gly Pro Gly  Gly Gly Asp Glu Pro  Pro Thr Ser 
    1190                 1195                 1200             


Pro Arg  Gln Leu Gln Pro Ala  Pro Pro Leu Ala Pro  Gln Gly Arg 
    1205                 1210                 1215             


Pro Trp  Thr Pro Gly Gln Pro  Gly Gly Leu Val Gly  Cys Pro Gly 
    1220                 1225                 1230             


Ser Gly  Gly Ser Pro Met Arg  Arg Glu Thr Ser Ala  Gly Phe Gln 
    1235                 1240                 1245             


Asn Gly  Leu Asn Tyr Ile Ala  Ile Asp Val Arg Glu  Glu Pro Gly 
    1250                 1255                 1260             


Leu Pro  Pro Gln Pro Gln Pro  Pro Pro Pro Pro Leu  Pro Gln Pro 
    1265                 1270                 1275             


Gly Asp  Lys Ser Ser Trp Gly  Arg Thr Arg Ser Leu  Gly Gly Leu 
    1280                 1285                 1290             


Ile Ser  Ala Val Gly Val Gly  Ser Thr Gly Gly Gly  Cys Gly Gly 
    1295                 1300                 1305             


Pro Gly  Pro Gly Ala Leu Pro  Pro Ala Asn Thr Tyr  Ala Ser Ile 
    1310                 1315                 1320             


Asp Phe  Leu Ser His His Leu  Lys Glu Ala Thr Ile  Val Lys Glu 
    1325                 1330                 1335             


<210>  48
<211>  2949
<212>  DNA
<213>  Homo sapiens

<400>  48
agtttcccga ccagagagaa cgaacgtgtc tgcgggcgcg cggggagcag aggcggtggc       60

gggcggcggc ggcaccggga gccgccgagt gaccctcccc cgcccctctg gccccccacc      120

ctcccacccg cccgtggccc gcgcccatgg ccgcgcgcgc tccacacaac tcaccggagt      180

ccgcgccttg cgccgccgac cagttcgcag ctccgcgcca cggcagccag tctcacctgg      240

cggcaccgcc cgcccaccgc cccggccaca gcccctgcgc ccacggcagc actcgaggcg      300

accgcgacag tggtggggga cgctgctgag tggaagagag cgcagcccgg ccaccggacc      360

tacttactcg ccttgctgat tgtctatttt tgcgtttaca acttttctaa gaacttttgt      420

atacaaagga actttttaaa aaagacgctt ccaagttata tttaatccaa agaagaagga      480

tctcggccaa tttggggttt tgggttttgg cttcgtttct tctcttcgtt gactttgggg      540

ttcaggtgcc ccagctgctt cgggctgccg aggaccttct gggcccccac attaatgagg      600

cagccacctg gcgagtctga catggctgtc agcgacgcgc tgctcccatc tttctccacg      660

ttcgcgtctg gcccggcggg aagggagaag acactgcgtc aagcaggtgc cccgaataac      720

cgctggcggg aggagctctc ccacatgaag cgacttcccc cagtgcttcc cggccgcccc      780

tatgacctgg cggcggcgac cgtggccaca gacctggaga gcggcggagc cggtgcggct      840

tgcggcggta gcaacctggc gcccctacct cggagagaga ccgaggagtt caacgatctc      900

ctggacctgg actttattct ctccaattcg ctgacccatc ctccggagtc agtggccgcc      960

accgtgtcct cgtcagcgtc agcctcctct tcgtcgtcgc cgtcgagcag cggccctgcc     1020

agcgcgccct ccacctgcag cttcacctat ccgatccggg ccgggaacga cccgggcgtg     1080

gcgccgggcg gcacgggcgg aggcctcctc tatggcaggg agtccgctcc ccctccgacg     1140

gctcccttca acctggcgga catcaacgac gtgagcccct cgggcggctt cgtggccgag     1200

ctcctgcggc cagaattgga cccggtgtac attccgccgc agcagccgca gccgccaggt     1260

ggcgggctga tgggcaagtt cgtgctgaag gcgtcgctga gcgcccctgg cagcgagtac     1320

ggcagcccgt cggtcatcag cgtcagcaaa ggcagccctg acggcagcca cccggtggtg     1380

gtggcgccct acaacggcgg gccgccgcgc acgtgcccca agatcaagca ggaggcggtc     1440

tcttcgtgca cccacttggg cgctggaccc cctctcagca atggccaccg gccggctgca     1500

cacgacttcc ccctggggcg gcagctcccc agcaggacta ccccgaccct gggtcttgag     1560

gaagtgctga gcagcaggga ctgtcaccct gccctgccgc ttcctcccgg cttccatccc     1620

cacccggggc ccaattaccc atccttcctg cccgatcaga tgcagccgca agtcccgccg     1680

ctccattacc aagagctcat gccacccggt tcctgcatgc cagaggagcc caagccaaag     1740

aggggaagac gatcgtggcc ccggaaaagg accgccaccc acacttgtga ttacgcgggc     1800

tgcggcaaaa cctacacaaa gagttcccat ctcaaggcac acctgcgaac ccacacaggt     1860

gagaaacctt accactgtga ctgggacggc tgtggatgga aattcgcccg ctcagatgaa     1920

ctgaccaggc actaccgtaa acacacgggg caccgcccgt tccagtgcca aaaatgcgac     1980

cgagcatttt ccaggtcgga ccacctcgcc ttacacatga agaggcattt ttaaatccca     2040

gacagtggat atgacccaca ctgccagaag agaattcagt attttttact tttcacactg     2100

tcttcccgat gagggaagga gcccagccag aaagcactac aatcatggtc aagttcccaa     2160

ctgagtcatc ttgtgagtgg ataatcagga aaaatgagga atccaaaaga caaaaatcaa     2220

agaacagatg gggtctgtga ctggatcttc tatcattcca attctaaatc cgacttgaat     2280

attcctggac ttacaaaatg ccaagggggt gactggaagt tgtggatatc agggtataaa     2340

ttatatccgt gagttggggg agggaagacc agaattccct tgaattgtgt attgatgcaa     2400

tataagcata aaagatcacc ttgtattctc tttaccttct aaaagccatt attatgatgt     2460

tagaagaaga ggaagaaatt caggtacaga aaacatgttt aaatagccta aatgatggtg     2520

cttggtgagt cttggttcta aaggtaccaa acaaggaagc caaagttttc aaactgctgc     2580

atactttgac aaggaaaatc tatatttgtc ttccgatcaa catttatgac ctaagtcagg     2640

taatatacct ggtttacttc tttagcattt ttatgcagac agtctgttat gcactgtggt     2700

ttcagatgtg caataatttg tacaatggtt tattcccaag tatgccttaa gcagaacaaa     2760

tgtgtttttc tatatagttc cttgccttaa taaatatgta atataaattt aagcaaacgt     2820

ctattttgta tatttgtaaa ctacaaagta aaatgaacat tttgtggagt ttgtattttg     2880

catactcaag gtgagaatta agttttaaat aaacctataa tattttatct gaaaaaaaaa     2940

aaaaaaaaa                                                             2949


<210>  49
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Arg Gln Pro Pro Gly Glu Ser Asp Met Ala Val Ser Asp Ala Leu 
1               5                   10                  15      


Leu Pro Ser Phe Ser Thr Phe Ala Ser Gly Pro Ala Gly Arg Glu Lys 
            20                  25                  30          


Thr Leu Arg Gln Ala Gly Ala Pro Asn Asn Arg Trp Arg Glu Glu Leu 
        35                  40                  45              


Ser His Met Lys Arg Leu Pro Pro Val Leu Pro Gly Arg Pro Tyr Asp 
    50                  55                  60                  


Leu Ala Ala Ala Thr Val Ala Thr Asp Leu Glu Ser Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ala Cys Gly Gly Ser Asn Leu Ala Pro Leu Pro Arg Arg Glu Thr 
                85                  90                  95      


Glu Glu Phe Asn Asp Leu Leu Asp Leu Asp Phe Ile Leu Ser Asn Ser 
            100                 105                 110         


Leu Thr His Pro Pro Glu Ser Val Ala Ala Thr Val Ser Ser Ser Ala 
        115                 120                 125             


Ser Ala Ser Ser Ser Ser Ser Pro Ser Ser Ser Gly Pro Ala Ser Ala 
    130                 135                 140                 


Pro Ser Thr Cys Ser Phe Thr Tyr Pro Ile Arg Ala Gly Asn Asp Pro 
145                 150                 155                 160 


Gly Val Ala Pro Gly Gly Thr Gly Gly Gly Leu Leu Tyr Gly Arg Glu 
                165                 170                 175     


Ser Ala Pro Pro Pro Thr Ala Pro Phe Asn Leu Ala Asp Ile Asn Asp 
            180                 185                 190         


Val Ser Pro Ser Gly Gly Phe Val Ala Glu Leu Leu Arg Pro Glu Leu 
        195                 200                 205             


Asp Pro Val Tyr Ile Pro Pro Gln Gln Pro Gln Pro Pro Gly Gly Gly 
    210                 215                 220                 


Leu Met Gly Lys Phe Val Leu Lys Ala Ser Leu Ser Ala Pro Gly Ser 
225                 230                 235                 240 


Glu Tyr Gly Ser Pro Ser Val Ile Ser Val Ser Lys Gly Ser Pro Asp 
                245                 250                 255     


Gly Ser His Pro Val Val Val Ala Pro Tyr Asn Gly Gly Pro Pro Arg 
            260                 265                 270         


Thr Cys Pro Lys Ile Lys Gln Glu Ala Val Ser Ser Cys Thr His Leu 
        275                 280                 285             


Gly Ala Gly Pro Pro Leu Ser Asn Gly His Arg Pro Ala Ala His Asp 
    290                 295                 300                 


Phe Pro Leu Gly Arg Gln Leu Pro Ser Arg Thr Thr Pro Thr Leu Gly 
305                 310                 315                 320 


Leu Glu Glu Val Leu Ser Ser Arg Asp Cys His Pro Ala Leu Pro Leu 
                325                 330                 335     


Pro Pro Gly Phe His Pro His Pro Gly Pro Asn Tyr Pro Ser Phe Leu 
            340                 345                 350         


Pro Asp Gln Met Gln Pro Gln Val Pro Pro Leu His Tyr Gln Glu Leu 
        355                 360                 365             


Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys Arg Gly 
    370                 375                 380                 


Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys Asp Tyr 
385                 390                 395                 400 


Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys Ala His 
                405                 410                 415     


Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Asp Trp Asp Gly 
            420                 425                 430         


Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg 
        435                 440                 445             


Lys His Thr Gly His Arg Pro Phe Gln Cys Gln Lys Cys Asp Arg Ala 
    450                 455                 460                 


Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Phe 
465                 470                 475                 


<210>  50
<211>  8228
<212>  DNA
<213>  Homo sapiens

<400>  50
ccgcgggtct atgggaagtt cggggacttg acagccgctg ccgccgcagg gcatttttgg       60

tcgaagagag ctgaagtaat gagaagacat catggaggcc cagtcccaca gctccacgac      120

cactgaaaag aaaaaagttg agaattccat agtgaagtgc tccactcgaa cagatgtgag      180

cgagaaagcc gttgcctcca gcaccacttc taatgaggat gaaagtcctg gacagactta      240

tcacagagag agaagaaacg caatcactat gcagccacag aatgtccagg ggctcagcaa      300

agtcagtgag gaaccttcaa catcgagtga cgagagggcc tcattgatca agaaagagat      360

ccatgggtcc ctgccacacg tggcggagcc ctctgtgccg taccgcggga cggtgtttgc      420

catggacccc aggaatggtt acatggagcc ccactaccac cctcctcatc ttttccctgc      480

cttccatcct cctgtaccaa ttgatgccag acatcatgag ggccgttacc attacgatcc      540

atctccgatt cctccattgc atatgacttc cgccttatct agtagcccta cgtatccgga      600

cctgcccttc attaggatct ccccacaccg gaaccccact gctgcttccg agtctccctt      660

cagccctcca catccctaca ttaatcccta catggactat atccgctcct tgcacagcag      720

cccatcgctc tccatgatct cagcaacccg tgggctgagc cctacagatg cgccccatgc      780

aggagtcagc ccagcagaat actatcatca gatggccctg ctaactggcc agcgcagccc      840

ctatgcagac attattccct cagctgccac cgccggcacg ggggccatcc acatggaata      900

tcttcatgct atggatagca ccagattctc cagccccagg ctgtcagcca ggccgagccg      960

aaaacgtaca ctgtccatat caccactctc cgatcatagc tttgaccttc agaccatgat     1020

aaggacgtct cccaactcct tggtcacgat tctcaataat tcccgtagca gctcttcagc     1080

aagtggctcc tatggtcact tatctgcaag tgcaatcagc cctgccttga gcttcaccta     1140

ctcttccgcg cccgtctctc tccacatgca tcagcagatc ctaagccgac aacagagctt     1200

aggttcagcc tttggacaca gccctccact catccaccct gccccaactt ttccaacaca     1260

gaggcctatt ccagggatcc ctacggttct gaaccccgtc caggtcagct ccggcccttc     1320

tgagtcctca cagaacaagc ccacgagtga gtctgcagtg agcagcactg gtgacccgat     1380

gcacaacaag aggtccaaga tcaaacccga tgaagacctc cccagcccag gggctcgggg     1440

gcagcaggaa cagcccgaag gaacaaccct tgtcaaggag gaaggggaca aagatgaaag     1500

caaacaggag cctgaagtca tctatgagac aaactgccac tgggaaggct gcgcgaggga     1560

gttcgacacc caagagcagc ttgtgcacca tataaataac gaccatattc atggagagaa     1620

gaaggagttc gtgtgcaggt ggctggactg ctcaagagag cagaaaccct tcaaagccca     1680

gtatatgttg gtagtgcata tgagaagaca cacgggcgag aagcctcaca aatgcacttt     1740

tgaaggttgc acaaaggcct actcgagact agaaaacttg aaaacacact tgagatctca     1800

cactggagag aaaccatacg tctgtgagca cgaaggttgc aacaaggctt tctcaaatgc     1860

ctctgatcgc gccaaacacc aaaacagaac gcattccaat gagaaaccat atgtgtgcaa     1920

aatcccaggc tgcactaagc gttacacaga cccaagctcc ctccggaaac atgtgaagac     1980

agtgcatggc ccagaggctc atgtcaccaa gaagcagcga ggggacatcc atcctcggcc     2040

gccacccccg agagattccg gcagccattc acagtccagg tcgcctggcc gaccgactca     2100

gggagccctt ggtgagcagc aggacctcag caacactacc tcaaagcggg aagaatgcct     2160

ccaggtgaaa accgtcaagg cagagaagcc aatgacatct cagccaagcc ctggtggtca     2220

gtcttcatgc agcagccaac agtcccccat cagcaactat tccaacagtg ggctcgagct     2280

tcctctgacc gatggaggta gtataggaga cctcagtgcc atcgatgaaa ccccaatcat     2340

ggactcaacc atttccactg caaccacagc ccttgctttg caagccagga gaaacccggc     2400

agggaccaaa tggatggagc acgtaaaact agaaaggcta aaacaagtga atggaatgtt     2460

tccgcgactg aaccccattc taccccctaa agcccctgcg gtctctcctc tcataggaaa     2520

tggcacacag tccaacaaca cctgcagctt gggtgggccc atgacgcttc tcccgggcag     2580

aagcgacctc tctggggtgg acgtcactat gctgaacatg ctcaacagaa gggacagcag     2640

cgccagcacc atcagctcgg cctacctgag cagccgccgc tcctcaggga tctcgccctg     2700

cttctccagc cgccgctcca gcgaggcgtc acaggccgag ggccggccgc agaacgtgag     2760

cgtggccgac tcctacgacc ccatctccac cgacgcctcg cgccgctcca gcgaagccag     2820

ccagagcgac ggcctgccca gcctgctcag cctcacgccc gcccagcagt accgcctcaa     2880

ggccaagtac gcggctgcca caggagggcc gccgccgacg cccctgccca acatggagag     2940

gatgagcctg aagacgcgcc tggcgctgct cggggatgcc ctcgagcctg gcgtggccct     3000

gcctccagtt catgccccga ggaggtgcag cgacggggga gcccacggct acgggcggcg     3060

ccacctgcag ccgcacgatg cgccgggcca cggcgtgagg agggccagcg acccggtgcg     3120

gacaggctcc gagggcctgg ccctgcctcg tgtgccgcgc ttcagcagcc tcagcagctg     3180

caaccccccg gcgatggcca cgtccgcgga gaagcgcagt ctcgtgcttc agaattacac     3240

gcggcccgag ggcggccagt cccgaaactt ccactcgtcc ccctgtcctc ccagcatcac     3300

cgagaacgtc accctggagt ccctgaccat ggacgctgat gccaacctga acgatgagga     3360

tttcctgccg gacgacgtgg tgcagtattt aaattcccag aaccaagcag ggtacgagca     3420

gcacttcccc agcgccctcc cggacgacag caaagtgccc cacgggcccg gtgactttga     3480

cgcgcccggg ctgccagaca gccacgctgg ccagcagttc catgccctcg agcagccctg     3540

ccccgagggc agcaaaaccg acctgcccat tcagtggaac gaagtcagct ccggaagcgc     3600

cgacctgtcc tcctccaagc tcaagtgtgg gccgcggccc gctgtgccgc agactcgcgc     3660

ctttgggttc tgcaacggca tggtcgtcca cccgcagaac cccttgagga gcgggcctgc     3720

tgggggctat cagaccctcg gggagaacag caacccctac ggtggcccag agcacttgat     3780

gctccacaac agccccggaa gtggcaccag tggaaacgcc ttccatgaac agccctgtaa     3840

ggccccgcag tatgggaact gtctcaacag gcagccagtg gcccctggtg cactcgacgg     3900

tgcctgtggt gccgggattc aagcctcaaa gctgaagagc acccccatgc aagggagcgg     3960

gggccagctg aatttcggcc tgccggtagc gccaaatgag tcagctggca gcatggtgaa     4020

tggcatgcag aaccaggacc cagtgggaca ggggtacctg gctcaccagc tcctcggcga     4080

cagcatgcag cacccggggg caggccgccc cggtcagcag atgcttgggc agattagtgc     4140

tacctcacac atcaacatct accaagggcc agagagctgc ctgccagggg ctcacggcat     4200

gggcagccag ccgtcaagct tggcagttgt caggggctac cagccatgtg ccagctttgg     4260

gggcagcagg cgccaggcta tgccgaggga cagccttgct ctgcagtcag gacagctcag     4320

tgacacaagt cagacctgca gggtgaatgg tatcaagatg gagatgaaag ggcagcccca     4380

tccgctgtgc tctaatctgc agaattactc tggtcagttc tatgaccaaa ccgtgggctt     4440

cagtcagcaa gacacgaaag ctggttcatt ctctatttca gacgccagct gcctgctaca     4500

ggggaccagc gccaaaaact ctgagttact ttccccaggt gctaatcagg tgacaagcac     4560

agtggacagc ctcgacagcc atgacctgga aggggtacag attgacttcg atgccatcat     4620

agacgatggg gaccactcca gcctgatgtc gggggccctg agcccaagta tcattcagaa     4680

cctttcccat agctcctccc gcctcaccac gcctcgggcg tccctcccat tcccagcgct     4740

gtccatgagc accaccaaca tggctatcgg ggacatgagt tctttgctga cctccctagc     4800

ggaagaaagc aaattccttg cagttatgca ataggcttta ggaaaaaaag actgcaacca     4860

acggaaatca ataggagttg aagagattaa actgactttg ttttggctgt ttttttagtt     4920

ctgtatgtat tttagcaatc tcatctcacc taactgagat gtgtttcaat tatattcctt     4980

ttatggaaaa ggactctgaa aaaccctaaa gtattctagg gagaaactgt cttccatttc     5040

agttttgaat cagtattgtt acactcaaac caccctcttt ttaaaaaaaa aaaaaaaaac     5100

tgtaagcccc gccccctttt tagtaaaccg atgtaaattt gtgatgtgca tattcttctt     5160

tcttttagaa gagcagtcaa attaaaggat ttgacatgtt ttgctgttgc tcaaaggaaa     5220

taggagttgg tgtgcttgtg accaaggggt tacacttcca gcttttaaaa ttctccttta     5280

catgtgctca gtgttttgtt ttgtgttttg gtttctgttt tttattttaa ttcccacatt     5340

gggcacaaga atcagaatat ggatagctag tttaagaaac ttttgtgggt gcactgtagc     5400

atagatgaca gaatattgat gttcccccca tctccaattc agttcagggc attccacagt     5460

taaacagaaa tgggaacgtg gggctcttat aaatgaaatg ggcgctcaca gttttggttt     5520

tcagctcttc atgtctgtaa gtgtgctttg ggggaggcta tgtctgtatg gtcgattctc     5580

agttatcaca tttgcctctc ctcccactac cttcatgaac attcagtgct gtttcgcact     5640

gcagttagag agaagggacg gacagttggt gacactcagc cacattgcta cttttatctg     5700

ttctggtaag aagttagata gatggtagat tgaagcaatt gggtagaatt agttggggga     5760

atatttatga gttgctgtgt ttgttgatta gttccatctc tttcccattt taactgagaa     5820

ttgattatat atagctctaa gtatataggt atttaaacaa ccccacaagc ggctgtatca     5880

gtaacattta ttaattccac tatagtgagg gaggatttcc attctaaata ccttattttg     5940

agggatttat aaaacttagt tgtaaaagag aaagcccaca tagtgggaat aaattgcttc     6000

agccattttt agtatttgag agcactaggg aagatgttta gtagctgtgt ggatgccttt     6060

tttcacaccc tgtctattga atgctgcatc cattcacgaa gttaaatgtt acatgcagtt     6120

agtccttaat gtggactgga tctgtacttt tgttttggat taaaacattt aaagattttt     6180

gaagtgcagc tactccccac gtgcatttga tacacataaa agtcatactg tgtgtgcaca     6240

aagagtacat ggattttcca gcatattgct ttaaaaaatt atataaactg ttaaaatatt     6300

aacacctcag gctacctgct gtattctgtc ccattgaccc ctggaattgg atttactgca     6360

agtgattgat aattcaatta tgtggctttt cccctttaat cttgccattt aaattacagt     6420

agaaagacaa aatcaagtaa aataaagtgt tagataatag aaagagtgtt aagaccagcc     6480

cacttttctc atgtttatgt tctttcattt ggaccaagaa tctccgcatg gaggttgatt     6540

tgccactggg gactttggct aagactatta ggtttgcttt caactagatg ttcctgagac     6600

aagcagaggg acactgcaat tccccttcca tgcctgctgt tctcccccat gtaagtcttc     6660

tttgaaatta acggatgtgt ctcctttgga acagccccat aacaaaagag aactactgat     6720

ctgagcatag gaaagtagag gctctaccac ttttcagttg aaaaagcaag actttctctg     6780

tgtttctgaa acaaggcata atgttgtcac agaatcagag atccagtctc acttttccac     6840

aaatctccaa atctccagtc ttatcttgtg tgctctaatg gtttggttca atccctttcc     6900

aactcttgtt ttcaaagcat ggggcctgag tgttctccac tcctcctaag aaaggagctt     6960

gggtggaagg gaccatgctg acctcctcca tcagagggct cttccagtag tattctcgga     7020

tgcaacctcc atttctcagt taccattatt tcctgtatca gctttgtcct tcctggaggg     7080

atgcacagtg atccggccca ccactgttgt tgtcttgtgc ttctgctctt tcctatggtt     7140

tcaggttatt ttctgggttt cccctattct tcttttattt cttttttttt ttatatttgc     7200

tttcctttct actgctttta gatttgcagg agatgcaagt ttcagctcaa tgtttggctt     7260

ctctcaatat ggaaatttca gaaggacaga ggagaggagg gaggaagaag aaagtatact     7320

cctccagaat ttcagtgatc tgttgtggca gtccagtgga aggaaggtct tttgaggtca     7380

cttagaagca tctttttggg acatcctttt gggatctctg taggctaggc atctcatatc     7440

ttgagactca cccccagcct ccaagcctct ctccatttct ctaacctatg cattttagag     7500

cgagaggacc gcctcactag tgtcaccatc ctgccttttc taaaacatgc aggctcacac     7560

attctactcc tgcttaatgt ctgtgttaaa cgttttctaa ccatttttgt tttatttttc     7620

tgaaaaagtt aacccctccc aactcctcac acattggctc ttcctcttga gccacaaagt     7680

tttgattctt gcgatgtatg tgccttattt tatgttaatc ttgtcaatga gagggaccag     7740

ttggtgttgc ccaatcagca ctccaaggct gtgtgtgcac cagccagaga gcgcacggtg     7800

gtagcagagt cgaggctgtc ttgtatcctg gtttcatgtg ttgttttgaa ctgataggag     7860

gatgttctct tctgacaagt tacccttgtg tatcctgcag acatgtaaaa taaaatacaa     7920

gttcattttt ttcacctttt ttagattttt ttaaaaaata aaatgtgtaa tccttttttt     7980

aaaagaaaca catgtaaata catttaagta ttgtaggcat agcgttcaga tgtgactggc     8040

ccaggcgttc ctcggacaag cctgcattcc ccgtgatcac gcccacctca agcccagggg     8100

ctgcagccca gccacagatg aactctacct ttgctttcag aaccacttag tccttttgta     8160

acaaagaaaa aaaaatgttt cttacaatgt caataaaaaa ttctttgtat ggaaaaaaaa     8220

aaaaaaaa                                                              8228


<210>  51
<211>  1580
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Glu Ala Gln Ser His Ser Ser Thr Thr Thr Glu Lys Lys Lys Val 
1               5                   10                  15      


Glu Asn Ser Ile Val Lys Cys Ser Thr Arg Thr Asp Val Ser Glu Lys 
            20                  25                  30          


Ala Val Ala Ser Ser Thr Thr Ser Asn Glu Asp Glu Ser Pro Gly Gln 
        35                  40                  45              


Thr Tyr His Arg Glu Arg Arg Asn Ala Ile Thr Met Gln Pro Gln Asn 
    50                  55                  60                  


Val Gln Gly Leu Ser Lys Val Ser Glu Glu Pro Ser Thr Ser Ser Asp 
65                  70                  75                  80  


Glu Arg Ala Ser Leu Ile Lys Lys Glu Ile His Gly Ser Leu Pro His 
                85                  90                  95      


Val Ala Glu Pro Ser Val Pro Tyr Arg Gly Thr Val Phe Ala Met Asp 
            100                 105                 110         


Pro Arg Asn Gly Tyr Met Glu Pro His Tyr His Pro Pro His Leu Phe 
        115                 120                 125             


Pro Ala Phe His Pro Pro Val Pro Ile Asp Ala Arg His His Glu Gly 
    130                 135                 140                 


Arg Tyr His Tyr Asp Pro Ser Pro Ile Pro Pro Leu His Met Thr Ser 
145                 150                 155                 160 


Ala Leu Ser Ser Ser Pro Thr Tyr Pro Asp Leu Pro Phe Ile Arg Ile 
                165                 170                 175     


Ser Pro His Arg Asn Pro Thr Ala Ala Ser Glu Ser Pro Phe Ser Pro 
            180                 185                 190         


Pro His Pro Tyr Ile Asn Pro Tyr Met Asp Tyr Ile Arg Ser Leu His 
        195                 200                 205             


Ser Ser Pro Ser Leu Ser Met Ile Ser Ala Thr Arg Gly Leu Ser Pro 
    210                 215                 220                 


Thr Asp Ala Pro His Ala Gly Val Ser Pro Ala Glu Tyr Tyr His Gln 
225                 230                 235                 240 


Met Ala Leu Leu Thr Gly Gln Arg Ser Pro Tyr Ala Asp Ile Ile Pro 
                245                 250                 255     


Ser Ala Ala Thr Ala Gly Thr Gly Ala Ile His Met Glu Tyr Leu His 
            260                 265                 270         


Ala Met Asp Ser Thr Arg Phe Ser Ser Pro Arg Leu Ser Ala Arg Pro 
        275                 280                 285             


Ser Arg Lys Arg Thr Leu Ser Ile Ser Pro Leu Ser Asp His Ser Phe 
    290                 295                 300                 


Asp Leu Gln Thr Met Ile Arg Thr Ser Pro Asn Ser Leu Val Thr Ile 
305                 310                 315                 320 


Leu Asn Asn Ser Arg Ser Ser Ser Ser Ala Ser Gly Ser Tyr Gly His 
                325                 330                 335     


Leu Ser Ala Ser Ala Ile Ser Pro Ala Leu Ser Phe Thr Tyr Ser Ser 
            340                 345                 350         


Ala Pro Val Ser Leu His Met His Gln Gln Ile Leu Ser Arg Gln Gln 
        355                 360                 365             


Ser Leu Gly Ser Ala Phe Gly His Ser Pro Pro Leu Ile His Pro Ala 
    370                 375                 380                 


Pro Thr Phe Pro Thr Gln Arg Pro Ile Pro Gly Ile Pro Thr Val Leu 
385                 390                 395                 400 


Asn Pro Val Gln Val Ser Ser Gly Pro Ser Glu Ser Ser Gln Asn Lys 
                405                 410                 415     


Pro Thr Ser Glu Ser Ala Val Ser Ser Thr Gly Asp Pro Met His Asn 
            420                 425                 430         


Lys Arg Ser Lys Ile Lys Pro Asp Glu Asp Leu Pro Ser Pro Gly Ala 
        435                 440                 445             


Arg Gly Gln Gln Glu Gln Pro Glu Gly Thr Thr Leu Val Lys Glu Glu 
    450                 455                 460                 


Gly Asp Lys Asp Glu Ser Lys Gln Glu Pro Glu Val Ile Tyr Glu Thr 
465                 470                 475                 480 


Asn Cys His Trp Glu Gly Cys Ala Arg Glu Phe Asp Thr Gln Glu Gln 
                485                 490                 495     


Leu Val His His Ile Asn Asn Asp His Ile His Gly Glu Lys Lys Glu 
            500                 505                 510         


Phe Val Cys Arg Trp Leu Asp Cys Ser Arg Glu Gln Lys Pro Phe Lys 
        515                 520                 525             


Ala Gln Tyr Met Leu Val Val His Met Arg Arg His Thr Gly Glu Lys 
    530                 535                 540                 


Pro His Lys Cys Thr Phe Glu Gly Cys Thr Lys Ala Tyr Ser Arg Leu 
545                 550                 555                 560 


Glu Asn Leu Lys Thr His Leu Arg Ser His Thr Gly Glu Lys Pro Tyr 
                565                 570                 575     


Val Cys Glu His Glu Gly Cys Asn Lys Ala Phe Ser Asn Ala Ser Asp 
            580                 585                 590         


Arg Ala Lys His Gln Asn Arg Thr His Ser Asn Glu Lys Pro Tyr Val 
        595                 600                 605             


Cys Lys Ile Pro Gly Cys Thr Lys Arg Tyr Thr Asp Pro Ser Ser Leu 
    610                 615                 620                 


Arg Lys His Val Lys Thr Val His Gly Pro Glu Ala His Val Thr Lys 
625                 630                 635                 640 


Lys Gln Arg Gly Asp Ile His Pro Arg Pro Pro Pro Pro Arg Asp Ser 
                645                 650                 655     


Gly Ser His Ser Gln Ser Arg Ser Pro Gly Arg Pro Thr Gln Gly Ala 
            660                 665                 670         


Leu Gly Glu Gln Gln Asp Leu Ser Asn Thr Thr Ser Lys Arg Glu Glu 
        675                 680                 685             


Cys Leu Gln Val Lys Thr Val Lys Ala Glu Lys Pro Met Thr Ser Gln 
    690                 695                 700                 


Pro Ser Pro Gly Gly Gln Ser Ser Cys Ser Ser Gln Gln Ser Pro Ile 
705                 710                 715                 720 


Ser Asn Tyr Ser Asn Ser Gly Leu Glu Leu Pro Leu Thr Asp Gly Gly 
                725                 730                 735     


Ser Ile Gly Asp Leu Ser Ala Ile Asp Glu Thr Pro Ile Met Asp Ser 
            740                 745                 750         


Thr Ile Ser Thr Ala Thr Thr Ala Leu Ala Leu Gln Ala Arg Arg Asn 
        755                 760                 765             


Pro Ala Gly Thr Lys Trp Met Glu His Val Lys Leu Glu Arg Leu Lys 
    770                 775                 780                 


Gln Val Asn Gly Met Phe Pro Arg Leu Asn Pro Ile Leu Pro Pro Lys 
785                 790                 795                 800 


Ala Pro Ala Val Ser Pro Leu Ile Gly Asn Gly Thr Gln Ser Asn Asn 
                805                 810                 815     


Thr Cys Ser Leu Gly Gly Pro Met Thr Leu Leu Pro Gly Arg Ser Asp 
            820                 825                 830         


Leu Ser Gly Val Asp Val Thr Met Leu Asn Met Leu Asn Arg Arg Asp 
        835                 840                 845             


Ser Ser Ala Ser Thr Ile Ser Ser Ala Tyr Leu Ser Ser Arg Arg Ser 
    850                 855                 860                 


Ser Gly Ile Ser Pro Cys Phe Ser Ser Arg Arg Ser Ser Glu Ala Ser 
865                 870                 875                 880 


Gln Ala Glu Gly Arg Pro Gln Asn Val Ser Val Ala Asp Ser Tyr Asp 
                885                 890                 895     


Pro Ile Ser Thr Asp Ala Ser Arg Arg Ser Ser Glu Ala Ser Gln Ser 
            900                 905                 910         


Asp Gly Leu Pro Ser Leu Leu Ser Leu Thr Pro Ala Gln Gln Tyr Arg 
        915                 920                 925             


Leu Lys Ala Lys Tyr Ala Ala Ala Thr Gly Gly Pro Pro Pro Thr Pro 
    930                 935                 940                 


Leu Pro Asn Met Glu Arg Met Ser Leu Lys Thr Arg Leu Ala Leu Leu 
945                 950                 955                 960 


Gly Asp Ala Leu Glu Pro Gly Val Ala Leu Pro Pro Val His Ala Pro 
                965                 970                 975     


Arg Arg Cys Ser Asp Gly Gly Ala His Gly Tyr Gly Arg Arg His Leu 
            980                 985                 990         


Gln Pro His Asp Ala Pro Gly His  Gly Val Arg Arg Ala  Ser Asp Pro 
        995                 1000                 1005             


Val Arg  Thr Gly Ser Glu Gly  Leu Ala Leu Pro Arg  Val Pro Arg 
    1010                 1015                 1020             


Phe Ser  Ser Leu Ser Ser Cys  Asn Pro Pro Ala Met  Ala Thr Ser 
    1025                 1030                 1035             


Ala Glu  Lys Arg Ser Leu Val  Leu Gln Asn Tyr Thr  Arg Pro Glu 
    1040                 1045                 1050             


Gly Gly  Gln Ser Arg Asn Phe  His Ser Ser Pro Cys  Pro Pro Ser 
    1055                 1060                 1065             


Ile Thr  Glu Asn Val Thr Leu  Glu Ser Leu Thr Met  Asp Ala Asp 
    1070                 1075                 1080             


Ala Asn  Leu Asn Asp Glu Asp  Phe Leu Pro Asp Asp  Val Val Gln 
    1085                 1090                 1095             


Tyr Leu  Asn Ser Gln Asn Gln  Ala Gly Tyr Glu Gln  His Phe Pro 
    1100                 1105                 1110             


Ser Ala  Leu Pro Asp Asp Ser  Lys Val Pro His Gly  Pro Gly Asp 
    1115                 1120                 1125             


Phe Asp  Ala Pro Gly Leu Pro  Asp Ser His Ala Gly  Gln Gln Phe 
    1130                 1135                 1140             


His Ala  Leu Glu Gln Pro Cys  Pro Glu Gly Ser Lys  Thr Asp Leu 
    1145                 1150                 1155             


Pro Ile  Gln Trp Asn Glu Val  Ser Ser Gly Ser Ala  Asp Leu Ser 
    1160                 1165                 1170             


Ser Ser  Lys Leu Lys Cys Gly  Pro Arg Pro Ala Val  Pro Gln Thr 
    1175                 1180                 1185             


Arg Ala  Phe Gly Phe Cys Asn  Gly Met Val Val His  Pro Gln Asn 
    1190                 1195                 1200             


Pro Leu  Arg Ser Gly Pro Ala  Gly Gly Tyr Gln Thr  Leu Gly Glu 
    1205                 1210                 1215             


Asn Ser  Asn Pro Tyr Gly Gly  Pro Glu His Leu Met  Leu His Asn 
    1220                 1225                 1230             


Ser Pro  Gly Ser Gly Thr Ser  Gly Asn Ala Phe His  Glu Gln Pro 
    1235                 1240                 1245             


Cys Lys  Ala Pro Gln Tyr Gly  Asn Cys Leu Asn Arg  Gln Pro Val 
    1250                 1255                 1260             


Ala Pro  Gly Ala Leu Asp Gly  Ala Cys Gly Ala Gly  Ile Gln Ala 
    1265                 1270                 1275             


Ser Lys  Leu Lys Ser Thr Pro  Met Gln Gly Ser Gly  Gly Gln Leu 
    1280                 1285                 1290             


Asn Phe  Gly Leu Pro Val Ala  Pro Asn Glu Ser Ala  Gly Ser Met 
    1295                 1300                 1305             


Val Asn  Gly Met Gln Asn Gln  Asp Pro Val Gly Gln  Gly Tyr Leu 
    1310                 1315                 1320             


Ala His  Gln Leu Leu Gly Asp  Ser Met Gln His Pro  Gly Ala Gly 
    1325                 1330                 1335             


Arg Pro  Gly Gln Gln Met Leu  Gly Gln Ile Ser Ala  Thr Ser His 
    1340                 1345                 1350             


Ile Asn  Ile Tyr Gln Gly Pro  Glu Ser Cys Leu Pro  Gly Ala His 
    1355                 1360                 1365             


Gly Met  Gly Ser Gln Pro Ser  Ser Leu Ala Val Val  Arg Gly Tyr 
    1370                 1375                 1380             


Gln Pro  Cys Ala Ser Phe Gly  Gly Ser Arg Arg Gln  Ala Met Pro 
    1385                 1390                 1395             


Arg Asp  Ser Leu Ala Leu Gln  Ser Gly Gln Leu Ser  Asp Thr Ser 
    1400                 1405                 1410             


Gln Thr  Cys Arg Val Asn Gly  Ile Lys Met Glu Met  Lys Gly Gln 
    1415                 1420                 1425             


Pro His  Pro Leu Cys Ser Asn  Leu Gln Asn Tyr Ser  Gly Gln Phe 
    1430                 1435                 1440             


Tyr Asp  Gln Thr Val Gly Phe  Ser Gln Gln Asp Thr  Lys Ala Gly 
    1445                 1450                 1455             


Ser Phe  Ser Ile Ser Asp Ala  Ser Cys Leu Leu Gln  Gly Thr Ser 
    1460                 1465                 1470             


Ala Lys  Asn Ser Glu Leu Leu  Ser Pro Gly Ala Asn  Gln Val Thr 
    1475                 1480                 1485             


Ser Thr  Val Asp Ser Leu Asp  Ser His Asp Leu Glu  Gly Val Gln 
    1490                 1495                 1500             


Ile Asp  Phe Asp Ala Ile Ile  Asp Asp Gly Asp His  Ser Ser Leu 
    1505                 1510                 1515             


Met Ser  Gly Ala Leu Ser Pro  Ser Ile Ile Gln Asn  Leu Ser His 
    1520                 1525                 1530             


Ser Ser  Ser Arg Leu Thr Thr  Pro Arg Ala Ser Leu  Pro Phe Pro 
    1535                 1540                 1545             


Ala Leu  Ser Met Ser Thr Thr  Asn Met Ala Ile Gly  Asp Met Ser 
    1550                 1555                 1560             


Ser Leu  Leu Thr Ser Leu Ala  Glu Glu Ser Lys Phe  Leu Ala Val 
    1565                 1570                 1575             


Met Gln  
    1580 


<210>  52
<211>  7014
<212>  DNA
<213>  Homo sapiens

<400>  52
cggggaccgc gacgagcccg ggtcgccgtt ggcagcagca gcagcaacac cagcagcagc       60

agcagccccg gcggcggcgc ggaccccgag cgcccgggcg caccccggct tcccggagcg      120

cgacgcggcg gcagcagccc cggtgcggcc gcgcgcgcct taggctcggc cccgcggctc      180

ggggaccccg actcccggcc cagcgagcgc gtcccccggc gccgcccgag agcccgagga      240

ggcagcggcc gcaggcagcc ggggaggggg gcggccaccg cccgcgccgg gcatcctcag      300

gagccccaga gcgcggaggg cgcggcgccg ccgagcggtg ctggcccccg cgggcctccc      360

cggaccttcc ccaccgcctg ggcccgaggg acgcgtgatc gggcgggcgg ccgggcgcaa      420

gggtgggagg gagccgcccc cgcccgcgcc ccctccgccc ctcgccccaa cccctgggcg      480

ccgggcccgg gccgcgcggc ctgaagcgcc cgcgatggcg agcccgccgc ggcacgggcc      540

gcccgggccg gcgagcggag acggccccaa cctcaacaac aacaacaaca acaacaacca      600

cagcgtgcgc aagtgcggct acctgcgcaa gcagaagcat ggccacaagc gcttcttcgt      660

gctgcgcgga cccggcgcgg gcggcgacga ggcgacggcg ggcggggggt cggcgccgca      720

accgccgcgg ctcgagtact acgagagcga gaaaaagtgg cggagcaagg caggcgcgcc      780

gaaacgggtg atcgctctcg actgctgcct gaacatcaac aagcgcgccg acgccaagca      840

caagtacctg atcgccctct acaccaagga cgagtacttc gccgtggccg ccgagaacga      900

gcaggagcag gagggctggt accgcgcgct caccgacctg gtcagcgagg gccgcgcggc      960

cgccggagac gcgccccccg ccgccgcgcc cgccgcgtcc tgcagcgcct ccctgcccgg     1020

cgccctgggc ggctctgccg gcgccgccgg ggccgaggac agctacgggc tggtggctcc     1080

cgccacggcc gcctaccgtg aggtgtggca ggtgaacctg aagcccaagg gtctgggcca     1140

gagcaagaac ctgacggggg tgtaccgtct gtgcctgtct gcgcgcacca tcggcttcgt     1200

gaagctcaac tgcgagcagc cgtcggtgac gctgcagctc atgaacatcc gccgctgcgg     1260

ccactcggac agcttcttct tcatcgaggt gggccgctcg gccgtcacag gccccggcga     1320

gctgtggatg caggcggacg actcggtggt ggcgcagaac atccacgaga ccatcctgga     1380

ggccatgaag gcgctcaagg agctcttcga gttccggccg cgcagtaaga gccaatcgtc     1440

ggggtcgtcg gccacgcacc ccatcagcgt ccccggcgcg cgccgccacc accacctggt     1500

caacctgccc cccagccaga cgggcctggt gcgccgctcg cgcaccgaca gcctggccgc     1560

caccccgccg gcggccaagt gcagctcgtg ccgggtgcgc accgccagcg agggcgacgg     1620

cggcgcggcg gcgggagcgg cggccgcggg cgccaggccg gtgtcggtgg ctgggagccc     1680

cctgagcccc gggccggtgc gcgcgcccct gagccgctcg cacaccctga gcggcggctg     1740

cggcggccgc gggagcaagg tggcgctgct gccggcaggg ggcgcgctgc aacacagccg     1800

ctccatgtcc atgcccgtgg cgcactcgcc gcccgccgcc accagccccg gctccctgtc     1860

gtccagcagc ggccacggct cgggctccta cccgccgccg cccggcccgc acccgcctct     1920

gccgcatccg ctgcaccacg gccccggcca gcggccctcc agcggcagcg cctccgcctc     1980

gggctccccc agcgaccccg gcttcatgtc cctggacgag tacggctcca gcccaggcga     2040

cctgcgcgcc ttctgcagcc accgaagcaa cacgcccgag tccatcgcgg agacgccccc     2100

ggcccgagac ggcggcggcg gcggtgagtt ctacgggtac atgaccatgg acaggcccct     2160

gagccactgt ggccgctcct accgccgggt ctcgggggac gcggcccagg acctggaccg     2220

agggctgcgc aagaggacct actccctgac cacgccagcc cggcagcggc cggtgcccca     2280

gccctcctct gcctcgctgg atgaatacac cctgatgcgg gccaccttct cgggcagcgc     2340

gggccgcctc tgcccgtcct gccccgcgtc ctctcccaag gtggcctacc acccctaccc     2400

agaggactac ggagacatcg agatcggctc ccacaggagc tccagcagca acctgggggc     2460

agacgacggc tacatgccca tgacgcccgg cgcggccctc gcgggcagtg ggagcggcag     2520

ctgcaggagc gacgactaca tgcccatgag ccccgccagc gtgtccgccc ccaagcagat     2580

cttgcagccc agggccgccg ccgccgccgc cgccgccgtg ccttctgcgg ggcctgcggg     2640

gccagcaccc acctctgcgg cgggcaggac attcccggcg agcgggggcg gctacaaggc     2700

cagctcgccc gccgagagct cccccgagga cagtgggtac atgcgcatgt ggtgcggttc     2760

caagctgtcc atggagcatg cagatggcaa gctgctgccc aacggggact acctcaacgt     2820

gtcccccagc gacgcggtca ccacgggcac cccgcccgac ttcttctccg cagccctgca     2880

ccccggcggg gagccgctca ggggcgttcc cggctgctgc tacagctcct tgccccgctc     2940

ctacaaggcc ccctacacct gtggcgggga cagcgaccag tacgtgctca tgagctcccc     3000

cgtggggcgc atcctggagg aggagcgtct ggagcctcag gccacgccag ggcccagcca     3060

ggcggccagc gccttcgggg ccggccccac gcagccccct caccctgtag tgccttcgcc     3120

cgtgcggcct agcggcggcc gcccggaggg cttcttgggc cagcgcggcc gggcggtgag     3180

gcccacgcgc ctgtccctgg aggggctgcc cagcctgccc agcatgcacg agtacccact     3240

gccaccggag cccaagagcc ccggcgagta catcaacatc gactttggcg agcccggggc     3300

ccgcctgtcg ccgcccgcgc ctcccctgct ggcgtcggcg gcctcgtcct cctcgctctt     3360

gtccgccagc agcccggcct cgtcgctggg ctcaggcacc ccgggcacca gcagcgacag     3420

ccggcagcgg tctccgctct ccgactacat gaacctcgac ttcagctccc ccaagtctcc     3480

taagccgggc gccccgagcg gccaccccgt gggctccttg gacggcctcc tgtcccccga     3540

ggcctcctcc ccgtatccgc cgttgccccc gcgtccgtcc gcgtccccgt cgtcgtctct     3600

gcagccgccg ccaccgccgc cggccccggg ggagctgtac cgcctgcccc ccgcctcggc     3660

cgttgccacc gcccagggcc cgggcgccgc ctcatcgttg tcctcggaca ccggggacaa     3720

tggtgactac accgagatgg cttttggtgt ggccgccacc ccgccgcaac ctatcgcggc     3780

ccccccgaag ccagaagctg cccgcgtggc cagcccgacg tcgggcgtga agaggctgag     3840

cctcatggag caggtgtcgg gagtcgaggc cttcctgcag gccagccagc ccccggaccc     3900

ccaccgcggc gccaaggtca tccgcgcaga cccgcagggg ggccgccgcc gccacagttc     3960

cgagaccttc tcctccacca cgacggtcac ccccgtgtcc ccgtccttcg cccacaaccc     4020

caagcgccac aactcggcct ccgtggaaaa tgtctctctc aggaaaagca gcgagggcgg     4080

cgtgggtgtc ggccctggag ggggcgacga gccgcccacc tccccacgac agttgcagcc     4140

ggcgccccct ttggcaccgc agggccggcc gtggaccccg ggtcagcccg ggggcttggt     4200

cggttgtcct gggagcggtg gatcgcccat gcgcagagag acctctgccg gcttccagaa     4260

tggtctcaac tacatcgcca tcgacgtgag ggaggagccc gggctgccac cccagccgca     4320

gccgccgccg ccgccgcttc ctcagccggg agacaagagc tcctggggcc ggacccgaag     4380

cctcgggggt ctcatcagcg ctgtgggcgt cggcagcacc ggcggcgggt gcggggggcc     4440

gggtcccggt gccctgcccc ctgccaacac ctacgccagc attgacttct tgtcccacca     4500

cttgaaggag gccaccatcg tgaaagagtg aagatctgtc tggctttatc accaggatgt     4560

cacatgtcag agagtatcat taaaagaaga cgctcagcac tgtttcagcc cgaagctgct     4620

tgcagttttc ttttggatct gagcaatgac tgtgtttgga aacatctgtg gactctgtta     4680

gatgaggcac caacaaggca aggtcacctg cctctttccc ttgttcccgg atggggcatt     4740

catcattgtg ctgtttgcgt tttgttttgt tttgttttaa caaaattagc tgaagaagtt     4800

attctcaaga aaattggatg ttttcattgg ccttcttaaa ttgtggccag tgtcttttaa     4860

tttcttcttc ttttcctttt ggcaaagcag atataaccct cagcatgcta ggagagtgca     4920

cccgtaccta tggaagtggt aaaatctggt atttactggc ttacactcaa aacgaccaca     4980

gtcctacctc agttcaaggt aaagccggat ttccgtggcg ggggtcccac aggacctcct     5040

gtagtagccc ctgcgctgtg tgtctggagc gcggtcctcg gccttattga aatggtccaa     5100

gtagacagct gcttgttgga ttccagtgca ggtacctgcg atgtttacgt ccacaccgag     5160

cccagtgtgg gactgacatt tctcaatgga agtgaaattt gggattggac tttgaagacg     5220

gattactaaa taataattat tatatgtaac tgaagcaacc tacttttgaa aatcaactgt     5280

attgggtagt gggaggtggg agggaagggc tttgggaagg ggatgaatat ctctttttac     5340

ctttaacaga cttgtttaat cttctcgatg tagatgttta tgtaggtact tcacattgca     5400

aacgcctttt attctattta caagctcaga tgtctctgct ctcctgaatc ttgggcatgc     5460

ctttctgtaa ccaaaaatcc ctgtaggcgt gctagcaatt ccagggtggt ccgggtttgg     5520

cagatttgat ttttaaaaaa cgtattatct ttaataaaat gttattatgt caaccagtga     5580

ggctgccctg aacaaaaaaa acaaaaagaa aaaaaaaaaa ggaaagaaag aaactgataa     5640

aaagaggcat tccagcccct atgttattga tggaaaaaga aaaagaagaa aagcaatctc     5700

gcagtacatg ttacttgtcg aaaaaattcc ggacaagact acccttgttt tatgttttca     5760

gtattctgaa aataccagtg tgtggcagtt ctcgcagatg ttacctaaaa ctgctgaact     5820

tgaccggcag aatgttctgc cgttttctgc tccctcgaca cttgattgga gggctgtcga     5880

cctctcctcc cgtgggggct tccccagtgc ctatcttctc tgatagtcat ggagaggtta     5940

cactaattca ttggagatgt aagttgttgg ttttgttttg ttttgttttt agaaaaatat     6000

atataaatat ataatagata tctatcgcta tagaataatg cattaataaa atgaggcttt     6060

tttagaggaa gaccaaaaaa ttcaatgtct taaaaatata tttaatggca atgcaaaagt     6120

cttcctgctt ccgtgctgaa ctttagaaca gaggattgta ttgcaagaca aagttgaatg     6180

taaagtgatc tccctgaaca tttttaaggt tttacttttc tgaaattata catcacagca     6240

gtgcataggc catataatgt tagctggaag gtcaatttca gtgtatgata tactttatta     6300

agatgtataa aaatcctgaa gtttttattt agttttggga ataggcatca atgggtggta     6360

tttgctttgt aactcccccc aggtacgata gggactgaat atggaccctg ctgaaagcag     6420

tgtattgacg catatttaac tcgccctcta tccgtagagt agtcatgaca ctatacagat     6480

ggttcgtgtt catactgcag cttaaaacaa gcaaaataca cagatgataa tatgctaaat     6540

tttcctctat cctgtacatt tcacaaaaag gcatatgcaa tatttacatt tttaatttag     6600

tttacagaat ggaaccaaaa tgtataaatg ttatgtttgc taaaacttca caatgtatat     6660

tgggtctttg tacattttgc ctgacttacc ttaaatttaa aatatttttt gctatataaa     6720

ctttaacagt tattaaacag tgttttcttt ttgggtacgt attgtttctg gatatcaaga     6780

tgttaaatat atttcttgct attgtgatat gacaagagac ttaacttatc ttgctctgtc     6840

ttccactgta cacgctgtat ataggggtca atgtgatgct gctggagacg agaataaact     6900

ggactagaat agtgcattgt atttagtctg tattgatcat ggatgccctc cttaatagcc     6960

atatgcaata aaataaagta cattatttat gaaatgaaaa aaaaaaaaaa aaaa           7014


<210>  53
<211>  1338
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Ser Pro Pro Arg His Gly Pro Pro Gly Pro Ala Ser Gly Asp 
1               5                   10                  15      


Gly Pro Asn Leu Asn Asn Asn Asn Asn Asn Asn Asn His Ser Val Arg 
            20                  25                  30          


Lys Cys Gly Tyr Leu Arg Lys Gln Lys His Gly His Lys Arg Phe Phe 
        35                  40                  45              


Val Leu Arg Gly Pro Gly Ala Gly Gly Asp Glu Ala Thr Ala Gly Gly 
    50                  55                  60                  


Gly Ser Ala Pro Gln Pro Pro Arg Leu Glu Tyr Tyr Glu Ser Glu Lys 
65                  70                  75                  80  


Lys Trp Arg Ser Lys Ala Gly Ala Pro Lys Arg Val Ile Ala Leu Asp 
                85                  90                  95      


Cys Cys Leu Asn Ile Asn Lys Arg Ala Asp Ala Lys His Lys Tyr Leu 
            100                 105                 110         


Ile Ala Leu Tyr Thr Lys Asp Glu Tyr Phe Ala Val Ala Ala Glu Asn 
        115                 120                 125             


Glu Gln Glu Gln Glu Gly Trp Tyr Arg Ala Leu Thr Asp Leu Val Ser 
    130                 135                 140                 


Glu Gly Arg Ala Ala Ala Gly Asp Ala Pro Pro Ala Ala Ala Pro Ala 
145                 150                 155                 160 


Ala Ser Cys Ser Ala Ser Leu Pro Gly Ala Leu Gly Gly Ser Ala Gly 
                165                 170                 175     


Ala Ala Gly Ala Glu Asp Ser Tyr Gly Leu Val Ala Pro Ala Thr Ala 
            180                 185                 190         


Ala Tyr Arg Glu Val Trp Gln Val Asn Leu Lys Pro Lys Gly Leu Gly 
        195                 200                 205             


Gln Ser Lys Asn Leu Thr Gly Val Tyr Arg Leu Cys Leu Ser Ala Arg 
    210                 215                 220                 


Thr Ile Gly Phe Val Lys Leu Asn Cys Glu Gln Pro Ser Val Thr Leu 
225                 230                 235                 240 


Gln Leu Met Asn Ile Arg Arg Cys Gly His Ser Asp Ser Phe Phe Phe 
                245                 250                 255     


Ile Glu Val Gly Arg Ser Ala Val Thr Gly Pro Gly Glu Leu Trp Met 
            260                 265                 270         


Gln Ala Asp Asp Ser Val Val Ala Gln Asn Ile His Glu Thr Ile Leu 
        275                 280                 285             


Glu Ala Met Lys Ala Leu Lys Glu Leu Phe Glu Phe Arg Pro Arg Ser 
    290                 295                 300                 


Lys Ser Gln Ser Ser Gly Ser Ser Ala Thr His Pro Ile Ser Val Pro 
305                 310                 315                 320 


Gly Ala Arg Arg His His His Leu Val Asn Leu Pro Pro Ser Gln Thr 
                325                 330                 335     


Gly Leu Val Arg Arg Ser Arg Thr Asp Ser Leu Ala Ala Thr Pro Pro 
            340                 345                 350         


Ala Ala Lys Cys Ser Ser Cys Arg Val Arg Thr Ala Ser Glu Gly Asp 
        355                 360                 365             


Gly Gly Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala Arg Pro Val Ser 
    370                 375                 380                 


Val Ala Gly Ser Pro Leu Ser Pro Gly Pro Val Arg Ala Pro Leu Ser 
385                 390                 395                 400 


Arg Ser His Thr Leu Ser Gly Gly Cys Gly Gly Arg Gly Ser Lys Val 
                405                 410                 415     


Ala Leu Leu Pro Ala Gly Gly Ala Leu Gln His Ser Arg Ser Met Ser 
            420                 425                 430         


Met Pro Val Ala His Ser Pro Pro Ala Ala Thr Ser Pro Gly Ser Leu 
        435                 440                 445             


Ser Ser Ser Ser Gly His Gly Ser Gly Ser Tyr Pro Pro Pro Pro Gly 
    450                 455                 460                 


Pro His Pro Pro Leu Pro His Pro Leu His His Gly Pro Gly Gln Arg 
465                 470                 475                 480 


Pro Ser Ser Gly Ser Ala Ser Ala Ser Gly Ser Pro Ser Asp Pro Gly 
                485                 490                 495     


Phe Met Ser Leu Asp Glu Tyr Gly Ser Ser Pro Gly Asp Leu Arg Ala 
            500                 505                 510         


Phe Cys Ser His Arg Ser Asn Thr Pro Glu Ser Ile Ala Glu Thr Pro 
        515                 520                 525             


Pro Ala Arg Asp Gly Gly Gly Gly Gly Glu Phe Tyr Gly Tyr Met Thr 
    530                 535                 540                 


Met Asp Arg Pro Leu Ser His Cys Gly Arg Ser Tyr Arg Arg Val Ser 
545                 550                 555                 560 


Gly Asp Ala Ala Gln Asp Leu Asp Arg Gly Leu Arg Lys Arg Thr Tyr 
                565                 570                 575     


Ser Leu Thr Thr Pro Ala Arg Gln Arg Pro Val Pro Gln Pro Ser Ser 
            580                 585                 590         


Ala Ser Leu Asp Glu Tyr Thr Leu Met Arg Ala Thr Phe Ser Gly Ser 
        595                 600                 605             


Ala Gly Arg Leu Cys Pro Ser Cys Pro Ala Ser Ser Pro Lys Val Ala 
    610                 615                 620                 


Tyr His Pro Tyr Pro Glu Asp Tyr Gly Asp Ile Glu Ile Gly Ser His 
625                 630                 635                 640 


Arg Ser Ser Ser Ser Asn Leu Gly Ala Asp Asp Gly Tyr Met Pro Met 
                645                 650                 655     


Thr Pro Gly Ala Ala Leu Ala Gly Ser Gly Ser Gly Ser Cys Arg Ser 
            660                 665                 670         


Asp Asp Tyr Met Pro Met Ser Pro Ala Ser Val Ser Ala Pro Lys Gln 
        675                 680                 685             


Ile Leu Gln Pro Arg Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Ser 
    690                 695                 700                 


Ala Gly Pro Ala Gly Pro Ala Pro Thr Ser Ala Ala Gly Arg Thr Phe 
705                 710                 715                 720 


Pro Ala Ser Gly Gly Gly Tyr Lys Ala Ser Ser Pro Ala Glu Ser Ser 
                725                 730                 735     


Pro Glu Asp Ser Gly Tyr Met Arg Met Trp Cys Gly Ser Lys Leu Ser 
            740                 745                 750         


Met Glu His Ala Asp Gly Lys Leu Leu Pro Asn Gly Asp Tyr Leu Asn 
        755                 760                 765             


Val Ser Pro Ser Asp Ala Val Thr Thr Gly Thr Pro Pro Asp Phe Phe 
    770                 775                 780                 


Ser Ala Ala Leu His Pro Gly Gly Glu Pro Leu Arg Gly Val Pro Gly 
785                 790                 795                 800 


Cys Cys Tyr Ser Ser Leu Pro Arg Ser Tyr Lys Ala Pro Tyr Thr Cys 
                805                 810                 815     


Gly Gly Asp Ser Asp Gln Tyr Val Leu Met Ser Ser Pro Val Gly Arg 
            820                 825                 830         


Ile Leu Glu Glu Glu Arg Leu Glu Pro Gln Ala Thr Pro Gly Pro Ser 
        835                 840                 845             


Gln Ala Ala Ser Ala Phe Gly Ala Gly Pro Thr Gln Pro Pro His Pro 
    850                 855                 860                 


Val Val Pro Ser Pro Val Arg Pro Ser Gly Gly Arg Pro Glu Gly Phe 
865                 870                 875                 880 


Leu Gly Gln Arg Gly Arg Ala Val Arg Pro Thr Arg Leu Ser Leu Glu 
                885                 890                 895     


Gly Leu Pro Ser Leu Pro Ser Met His Glu Tyr Pro Leu Pro Pro Glu 
            900                 905                 910         


Pro Lys Ser Pro Gly Glu Tyr Ile Asn Ile Asp Phe Gly Glu Pro Gly 
        915                 920                 925             


Ala Arg Leu Ser Pro Pro Ala Pro Pro Leu Leu Ala Ser Ala Ala Ser 
    930                 935                 940                 


Ser Ser Ser Leu Leu Ser Ala Ser Ser Pro Ala Ser Ser Leu Gly Ser 
945                 950                 955                 960 


Gly Thr Pro Gly Thr Ser Ser Asp Ser Arg Gln Arg Ser Pro Leu Ser 
                965                 970                 975     


Asp Tyr Met Asn Leu Asp Phe Ser Ser Pro Lys Ser Pro Lys Pro Gly 
            980                 985                 990         


Ala Pro Ser Gly His Pro Val Gly  Ser Leu Asp Gly Leu  Leu Ser Pro 
        995                 1000                 1005             


Glu Ala  Ser Ser Pro Tyr Pro  Pro Leu Pro Pro Arg  Pro Ser Ala 
    1010                 1015                 1020             


Ser Pro  Ser Ser Ser Leu Gln  Pro Pro Pro Pro Pro  Pro Ala Pro 
    1025                 1030                 1035             


Gly Glu  Leu Tyr Arg Leu Pro  Pro Ala Ser Ala Val  Ala Thr Ala 
    1040                 1045                 1050             


Gln Gly  Pro Gly Ala Ala Ser  Ser Leu Ser Ser Asp  Thr Gly Asp 
    1055                 1060                 1065             


Asn Gly  Asp Tyr Thr Glu Met  Ala Phe Gly Val Ala  Ala Thr Pro 
    1070                 1075                 1080             


Pro Gln  Pro Ile Ala Ala Pro  Pro Lys Pro Glu Ala  Ala Arg Val 
    1085                 1090                 1095             


Ala Ser  Pro Thr Ser Gly Val  Lys Arg Leu Ser Leu  Met Glu Gln 
    1100                 1105                 1110             


Val Ser  Gly Val Glu Ala Phe  Leu Gln Ala Ser Gln  Pro Pro Asp 
    1115                 1120                 1125             


Pro His  Arg Gly Ala Lys Val  Ile Arg Ala Asp Pro  Gln Gly Gly 
    1130                 1135                 1140             


Arg Arg  Arg His Ser Ser Glu  Thr Phe Ser Ser Thr  Thr Thr Val 
    1145                 1150                 1155             


Thr Pro  Val Ser Pro Ser Phe  Ala His Asn Pro Lys  Arg His Asn 
    1160                 1165                 1170             


Ser Ala  Ser Val Glu Asn Val  Ser Leu Arg Lys Ser  Ser Glu Gly 
    1175                 1180                 1185             


Gly Val  Gly Val Gly Pro Gly  Gly Gly Asp Glu Pro  Pro Thr Ser 
    1190                 1195                 1200             


Pro Arg  Gln Leu Gln Pro Ala  Pro Pro Leu Ala Pro  Gln Gly Arg 
    1205                 1210                 1215             


Pro Trp  Thr Pro Gly Gln Pro  Gly Gly Leu Val Gly  Cys Pro Gly 
    1220                 1225                 1230             


Ser Gly  Gly Ser Pro Met Arg  Arg Glu Thr Ser Ala  Gly Phe Gln 
    1235                 1240                 1245             


Asn Gly  Leu Asn Tyr Ile Ala  Ile Asp Val Arg Glu  Glu Pro Gly 
    1250                 1255                 1260             


Leu Pro  Pro Gln Pro Gln Pro  Pro Pro Pro Pro Leu  Pro Gln Pro 
    1265                 1270                 1275             


Gly Asp  Lys Ser Ser Trp Gly  Arg Thr Arg Ser Leu  Gly Gly Leu 
    1280                 1285                 1290             


Ile Ser  Ala Val Gly Val Gly  Ser Thr Gly Gly Gly  Cys Gly Gly 
    1295                 1300                 1305             


Pro Gly  Pro Gly Ala Leu Pro  Pro Ala Asn Thr Tyr  Ala Ser Ile 
    1310                 1315                 1320             


Asp Phe  Leu Ser His His Leu  Lys Glu Ala Thr Ile  Val Lys Glu 
    1325                 1330                 1335             


<210>  54
<211>  7614
<212>  DNA
<213>  Homo sapiens

<400>  54
aggccccgcc cgggccaacc gcctgcctgg tccgccctct gaccaagatc actccatgga       60

tgaaatgaca gctgtggtga aaattgaaaa aggagttggt ggcaataatg ggggcaatgg      120

taatggtggt ggtgcctttt cacaggctcg aagtagcagc acaggcagta gcagcagcac      180

tggaggagga gggcaggagt cccagccatc ccctttggct ctgctggcag caacttgcag      240

cagaattgag tcacccaatg agaacagcaa caactcccag ggcccgagtc agtcaggggg      300

aacaggtgag cttgacctca cagccacaca actttcacag ggtgccaatg gctggcagat      360

catctcttcc tcctctgggg ctacccctac ctcaaaggaa cagagtggca gcagtaccaa      420

tggcagcaat ggcagtgagt cttccaagaa tcgcacagtc tctggtgggc agtatgttgt      480

ggctgccgct cccaacttac agaaccagca agttctgaca ggactacctg gagtgatgcc      540

taatattcag tatcaagtaa tcccacagtt ccagaccgtt gatgggcaac agctgcagtt      600

tgctgccact ggggcccaag tgcagcagga tggttctggt caaatacaga tcataccagg      660

tgcaaaccaa cagattatca caaatcgagg aagtggaggc aacatcattg ctgctatgcc      720

aaacctactc cagcaggctg tccccctcca aggcctggct aataatgtac tctcaggaca      780

gactcagtat gtgaccaatg taccagtggc cctgaatggg aacatcacct tgctacctgt      840

caacagcgtt tctgcagcta ccttgactcc cagctctcag gcagtcacga tcagcagctc      900

tgggtcccag gagagtggct cacagcctgt cacctcaggg actaccatca gttctgccag      960

cttggtatca tcacaagcca gttccagctc ctttttcacc aatgccaata gctactcaac     1020

tactactacc accagcaaca tgggaattat gaactttact accagtggat catcagggac     1080

caactctcaa ggccagacac cccagagggt cagtgggcta caggggtctg atgctctgaa     1140

catccagcaa aaccagacat ctggaggctc attgcaagca ggccagcaaa aagaaggaga     1200

gcaaaaccag cagacacagc agcaacaaat tcttatccag cctcagctag ttcaaggggg     1260

acaggccctc caggccctcc aagcagcacc attgtcaggg cagaccttta caactcaagc     1320

catctcccag gaaaccctcc agaacctcca gcttcaggct gttccaaact ctggtcccat     1380

catcatccgg acaccaacag tggggcccaa tggacaggtc agttggcaga ctctacagct     1440

gcagaacctc caagttcaga acccacaagc ccaaacaatc accttagccc caatgcaggg     1500

tgtttccttg gggcagacca gcagcagcaa caccactctc acacccattg cctcagctgc     1560

ttccattcct gctggcacag tcactgtgaa tgctgctcaa ctctcctcca tgccaggcct     1620

ccagaccatt aacctcagtg cattgggtac ttcaggaatc caggtgcacc caattcaagg     1680

cctgccgttg gctatagcaa atgccccagg tgatcatgga gctcagcttg gtctccatgg     1740

ggctggtggt gatggaatac atgatgacac agcaggtgga gaggaaggag aaaacagccc     1800

agatgcccaa ccccaagccg gtcggaggac ccggcgggaa gcatgcacct gcccctactg     1860

taaagacagt gaaggaaggg gctcggggga tcctggcaaa aagaaacagc atatttgcca     1920

catccaaggc tgtgggaaag tgtatggcaa gacctctcac ctgcgggcac acttgcgctg     1980

gcatacaggc gagaggccat ttatgtgtac ctggtcatac tgtgggaaac gcttcacacg     2040

ttcggatgag ctacagaggc acaaacgtac acacacaggt gagaagaaat ttgcctgccc     2100

tgagtgtcct aagcgcttca tgaggagtga ccacctgtca aaacatatca agacccacca     2160

gaataagaag ggaggcccag gtgtagctct gagtgtgggc actttgcccc tggacagtgg     2220

ggcaggttca gaaggcagtg gcactgccac tccttcagcc cttattacca ccaatatggt     2280

agccatggag gccatctgtc cagagggcat tgcccgtctt gccaacagtg gcatcaacgt     2340

catgcaggtg gcagatctgc agtccattaa tatcagtggc aatggcttct gagatcaggc     2400

acccggggcc agagacatat gggccatacc ccttaacccc gggatgcaag gtagcatggg     2460

tccaagagac atggaagaga gagccatgaa gcattaaaat gcatggtgtt gagaagaatc     2520

aggagaggga tacaagagag gagatggggt cccggcaccc atctgtatca tcagtgcctc     2580

tttgaaggtg ggaaacatta gtgaaaattc tgttggtgcc acgctttgat gagcatttgt     2640

ttgaccccag tttcttctta cacttcttac cccagcctac ccttcctgca tttctcttct     2700

cagctcttcc atgatggatt cccccccctt tcctaaagcc atcatgcctt gataaatata     2760

tatgatcatt gaaatacttt ttaacaaaaa acagattcta tattattata tatatatata     2820

tatatataaa gatatataga gatgcattca caggggttgg ctgggaggag gaagaccatt     2880

ctgtgaccaa aataccttgg tcattttttt tatattgcct tatttcccta tggctgagcc     2940

ttgttgtgac acatcaagct tttctgtaga tgttgtcttg gcttcccacc agcttaagcg     3000

ttcatatgct ctgcttttag ttcatatata catacataat gtttttcctt tcttaatttt     3060

gtctttttgt ttgggatcag cttcttgcac tccttcccta actcaactgt tgccgtctca     3120

tcttctctca tctgatcact tcatgttttg tttttgttac tgcctggatg aggcacttct     3180

gtcaattttt tcaggacctt agttccagca gcagaatgga aaaatccttg aagcccaggc     3240

tgatgcttga agtaactgtg gagggagtgt tcaaaatact actgacgcag gcaccttctt     3300

ggcgctggag agtcaaaggc atctcccttc attagctgct ctgagcatca agaattagaa     3360

gtctttcagt ggaattgtac aagagtccct ttgaagataa taatcttggc tcagtttgta     3420

taaactgtca aattttcaaa taataggtag ggggctttca ctaggaaaat catgtgctca     3480

gaagaggaaa tgactcgtag tcaggttcag gagttagtgg agtatttgga ctttggtact     3540

gctgtcttcc aaggtagctc taagttttga tgtgtgggct tctgagttta tattctgaaa     3600

ggaaatacac ttcttttgaa catccccact aggttctttt ccattgtcaa taaggagcat     3660

cagccagtga atctgtttca ggtttccatt ctgcagaact cctccaaagc atgtgctagt     3720

ggcaagacag tggttcttat gatgttttcc cttaactttt ccttgtatgt tcttgggtgg     3780

ttcctaaggg aaagggaagc acatgatcat gggaatgata gcccagaaca aaaagaaatc     3840

ttgtcttacc acagtgtttt ataggagaga ttgggagaaa tcatcctgtt ttctctgtga     3900

cctgatttca gaagagactg atccaaaaat tataacggca gggaacctag tgcatttggc     3960

actgagattt aaatgcaacc agaattgtcc tcaaggccca gccataaaag cattgtctct     4020

ctcgaccttc tggtatcttg ttagagagct tttcactgtg aggaagtgtg gaaaaatagc     4080

tctgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta atctgttagg ttggggatag     4140

gttttctgct agccaatatt aaaagagacc tgcaataaaa aaattaccct gatctgatag     4200

aaagcaagtg tttttgtatg tgtgggtgaa tgtgtgttca tgcccgtata tgtctacaca     4260

cagatgacaa attatatttg aaatcgttgg aaaataaatt cagatcaaaa tgcctttcag     4320

gcccattacc tagaaatcta tcttaaaacc tgggtatgtt cctaaggtca tttctttgct     4380

tatgctaaat taattacaat tatgaatgga ggatattcta ctgtactttt ttaaaaagaa     4440

actatttttg tgtttgaaag tgaaaccaac atccagatct atagcagagt ccttattctt     4500

ctcataaatc tttttacttt ggctacaaat agatgatggt atgattctat tatatatttt     4560

atataaaatc catccaaatt aagttttggg taagtgtgtt gtttaatctg aactatagta     4620

acttaatact ctaaacaata gttcactcca tttggtcctt tctccacaga tgtaattatg     4680

ttttcaactc aggaactatg gcaaggaact ttccccagat caaattctat taacgctgag     4740

atacaagtca tccatgcaca gccactatca taccctttat tctcactgaa aggcagaact     4800

cagaacctgt tattttatgt ctgtaatcat gtactttggc atcttttgga ggaaaggggc     4860

aggataactc actggaatgt acagtatttt gctagtgcat ttcaaggaat ggaatcttct     4920

ccagtatgaa attaccagat ataaaataat gtaatgatgc tgaggatata agcttttaga     4980

aggtaatttg atggtatttc tttctcgaat gaaaagctgc tggtttaccc tcaaccctat     5040

tcattagcat taccatgagt gaatttatat ctaattattt ccacttgccc tgttctcttc     5100

acaccaagga agctccagat ccagtatctt gtttggcctc aaaacagaag cagcttcttt     5160

tgtctcccag cagtagtgag ccactcagtc tcttccacag gaagtttgga gcctacattc     5220

cttgagtcag gagcttatta cagaaaaacc ccgtttccct gaacttttgg ctaacagaaa     5280

ttaatttaac tgacatgcat attgattctg aaattttttt cctaagtttt tttcattttt     5340

ttgaatgagt tttttaaatt ttttagatga ccaaaacttg cagggcaggg gatgcccaga     5400

agagtggtga gatagtaaaa cacttattcc ctcatccttt caggttttca ggttgcccat     5460

ttatattcat ttacatgtca tttgactgtc tcacttttta cccagaacag taacaaccca     5520

caccgtcttc cttcagggat ttccaactgg cactctgtgg gtgctacaca gaatgcaatt     5580

taatggatat ttctcagcct ggttcagaat aaattgatcc tttgatccca gaaagtatat     5640

actgaagtgt gggataaaga ttatgattag gggagggttg gagacaaaag ctgtaaatta     5700

ctatggctga tttatttcta ctatatacat atatattttt tgcttttgta tatcctatat     5760

aggaaactaa gcattgtatt ttttttaaca aatctaaaaa agcactatga actacaggtg     5820

tttgactttc aaaatatatt ttgtattgtt aatatcttca cattgtgtga atactggaag     5880

ctgcagatct ttgctaggac gcaataaatt tatatacttt ttgaggggtt cttctggggt     5940

gctaatcagg cccctgttat gcttaggggg agccctggtg ctacttgctt gaagttttca     6000

gtgtaagtac cctgatgcct tttggacctt gggatcagat caagagtttt ggagatcagg     6060

taccaaggaa ataaggacag tctagctgcc tcaagtgagg ggccctttgc atagctctcc     6120

ttccccctca ctgaagctgg gtagcctatt ggggttgaga gggaaaatgt gaaatctcag     6180

aatttatctc ccttagaaga gagccagtaa cttatgtaca aggatgaaag aaaggtcgca     6240

gcagtagctt tggggaaagg gaggaagata tggcacttct ccaaccccgg aaaacattgc     6300

ttttgaaaac tgctgataaa atatgagccg gttattactt ctgtttggga gactgtgctc     6360

tctgtggtgc ctctcttggc tctactccac agataccaga cctcttctaa gaggatgagc     6420

agaccagctt tgaggttgac ctgtttctct ttgtctgcct tcccaaaaca ccagccccca     6480

ggaagacatt aagcagcctt aagcttaaat tcctactccc tcttccaaat ttggctcact     6540

tgccttagat ccaaggcagg gaaaggaaaa gaaggggggt ctctggcttt attactcccc     6600

taagtcttta ctctgacttc cccaaaccca gaaagatttt ctccacagtg ttcatttgaa     6660

agaggagtat tttgtcccat tttccccttc ctcattatca aacagcccca gtcttccttg     6720

tctctgctaa gaaagtagag gcatgatgat ctgcctctca actgccctaa gtcctagcta     6780

agtatcaggg gaaaaaaaaa aaaaaaaagc ctaacaaatg ggattagact agggctgcaa     6840

gtagtgagga ttttgttgat acctctgctg ggatgtgtgc tttcccatat cttgccttca     6900

ggaattacac tgtgcctttt ccccagggat atgggctctg tctacccagt gctccagttt     6960

cccggtaact gctcttgaac attgtggaca agggcaggtc ttcatatttt tgatcatccc     7020

tttctcccag tgaaatccca tagcccttac ctagagtcta gggcacaaag acttcgggga     7080

agatacactg agattgacct gaggagacat ctacacacac cagtggcagc tgccccaggg     7140

cctgcttccc cttcctaagt ctgtcatcct ctggaaggga tgggtggtgc tccaatctct     7200

ggtgcctaaa aacccaagtt tatttctctc ttaacactgg caataaccag tccacaccac     7260

tgttgccttt taaaacctct taataatctc atgctgtgtt tgttttgatt ccaatccaat     7320

tatcaccagg gctgtgtggg taaatgcttt taaatgctct ctcatcttgt tcttccccct     7380

caccccccac tcttaggtat gtatgatgct aatcttgtcc ctaagtaagt ttcttcctgc     7440

tccttttgta tcttcctttc ttgtctttcc tcctaccttt tgtctcttgg tgttttggga     7500

cttttttttt tttttttttg gccttttgta caaagattag tttcaatgta gtctgtagcc     7560

tcctttgtaa accaattaaa aagtttttta ataaaaaaaa aaaaaaaaaa aaaa           7614


<210>  55
<211>  778
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Asp Glu Met Thr Ala Val Val Lys Ile Glu Lys Gly Val Gly Gly 
1               5                   10                  15      


Asn Asn Gly Gly Asn Gly Asn Gly Gly Gly Ala Phe Ser Gln Ala Arg 
            20                  25                  30          


Ser Ser Ser Thr Gly Ser Ser Ser Ser Thr Gly Gly Gly Gly Gln Glu 
        35                  40                  45              


Ser Gln Pro Ser Pro Leu Ala Leu Leu Ala Ala Thr Cys Ser Arg Ile 
    50                  55                  60                  


Glu Ser Pro Asn Glu Asn Ser Asn Asn Ser Gln Gly Pro Ser Gln Ser 
65                  70                  75                  80  


Gly Gly Thr Gly Glu Leu Asp Leu Thr Ala Thr Gln Leu Ser Gln Gly 
                85                  90                  95      


Ala Asn Gly Trp Gln Ile Ile Ser Ser Ser Ser Gly Ala Thr Pro Thr 
            100                 105                 110         


Ser Lys Glu Gln Ser Gly Ser Ser Thr Asn Gly Ser Asn Gly Ser Glu 
        115                 120                 125             


Ser Ser Lys Asn Arg Thr Val Ser Gly Gly Gln Tyr Val Val Ala Ala 
    130                 135                 140                 


Ala Pro Asn Leu Gln Asn Gln Gln Val Leu Thr Gly Leu Pro Gly Val 
145                 150                 155                 160 


Met Pro Asn Ile Gln Tyr Gln Val Ile Pro Gln Phe Gln Thr Val Asp 
                165                 170                 175     


Gly Gln Gln Leu Gln Phe Ala Ala Thr Gly Ala Gln Val Gln Gln Asp 
            180                 185                 190         


Gly Ser Gly Gln Ile Gln Ile Ile Pro Gly Ala Asn Gln Gln Ile Ile 
        195                 200                 205             


Thr Asn Arg Gly Ser Gly Gly Asn Ile Ile Ala Ala Met Pro Asn Leu 
    210                 215                 220                 


Leu Gln Gln Ala Val Pro Leu Gln Gly Leu Ala Asn Asn Val Leu Ser 
225                 230                 235                 240 


Gly Gln Thr Gln Tyr Val Thr Asn Val Pro Val Ala Leu Asn Gly Asn 
                245                 250                 255     


Ile Thr Leu Leu Pro Val Asn Ser Val Ser Ala Ala Thr Leu Thr Pro 
            260                 265                 270         


Ser Ser Gln Ala Val Thr Ile Ser Ser Ser Gly Ser Gln Glu Ser Gly 
        275                 280                 285             


Ser Gln Pro Val Thr Ser Gly Thr Thr Ile Ser Ser Ala Ser Leu Val 
    290                 295                 300                 


Ser Ser Gln Ala Ser Ser Ser Ser Phe Phe Thr Asn Ala Asn Ser Tyr 
305                 310                 315                 320 


Ser Thr Thr Thr Thr Thr Ser Asn Met Gly Ile Met Asn Phe Thr Thr 
                325                 330                 335     


Ser Gly Ser Ser Gly Thr Asn Ser Gln Gly Gln Thr Pro Gln Arg Val 
            340                 345                 350         


Ser Gly Leu Gln Gly Ser Asp Ala Leu Asn Ile Gln Gln Asn Gln Thr 
        355                 360                 365             


Ser Gly Gly Ser Leu Gln Ala Gly Gln Gln Lys Glu Gly Glu Gln Asn 
    370                 375                 380                 


Gln Gln Thr Gln Gln Gln Gln Ile Leu Ile Gln Pro Gln Leu Val Gln 
385                 390                 395                 400 


Gly Gly Gln Ala Leu Gln Ala Leu Gln Ala Ala Pro Leu Ser Gly Gln 
                405                 410                 415     


Thr Phe Thr Thr Gln Ala Ile Ser Gln Glu Thr Leu Gln Asn Leu Gln 
            420                 425                 430         


Leu Gln Ala Val Pro Asn Ser Gly Pro Ile Ile Ile Arg Thr Pro Thr 
        435                 440                 445             


Val Gly Pro Asn Gly Gln Val Ser Trp Gln Thr Leu Gln Leu Gln Asn 
    450                 455                 460                 


Leu Gln Val Gln Asn Pro Gln Ala Gln Thr Ile Thr Leu Ala Pro Met 
465                 470                 475                 480 


Gln Gly Val Ser Leu Gly Gln Thr Ser Ser Ser Asn Thr Thr Leu Thr 
                485                 490                 495     


Pro Ile Ala Ser Ala Ala Ser Ile Pro Ala Gly Thr Val Thr Val Asn 
            500                 505                 510         


Ala Ala Gln Leu Ser Ser Met Pro Gly Leu Gln Thr Ile Asn Leu Ser 
        515                 520                 525             


Ala Leu Gly Thr Ser Gly Ile Gln Val His Pro Ile Gln Gly Leu Pro 
    530                 535                 540                 


Leu Ala Ile Ala Asn Ala Pro Gly Asp His Gly Ala Gln Leu Gly Leu 
545                 550                 555                 560 


His Gly Ala Gly Gly Asp Gly Ile His Asp Asp Thr Ala Gly Gly Glu 
                565                 570                 575     


Glu Gly Glu Asn Ser Pro Asp Ala Gln Pro Gln Ala Gly Arg Arg Thr 
            580                 585                 590         


Arg Arg Glu Ala Cys Thr Cys Pro Tyr Cys Lys Asp Ser Glu Gly Arg 
        595                 600                 605             


Gly Ser Gly Asp Pro Gly Lys Lys Lys Gln His Ile Cys His Ile Gln 
    610                 615                 620                 


Gly Cys Gly Lys Val Tyr Gly Lys Thr Ser His Leu Arg Ala His Leu 
625                 630                 635                 640 


Arg Trp His Thr Gly Glu Arg Pro Phe Met Cys Thr Trp Ser Tyr Cys 
                645                 650                 655     


Gly Lys Arg Phe Thr Arg Ser Asp Glu Leu Gln Arg His Lys Arg Thr 
            660                 665                 670         


His Thr Gly Glu Lys Lys Phe Ala Cys Pro Glu Cys Pro Lys Arg Phe 
        675                 680                 685             


Met Arg Ser Asp His Leu Ser Lys His Ile Lys Thr His Gln Asn Lys 
    690                 695                 700                 


Lys Gly Gly Pro Gly Val Ala Leu Ser Val Gly Thr Leu Pro Leu Asp 
705                 710                 715                 720 


Ser Gly Ala Gly Ser Glu Gly Ser Gly Thr Ala Thr Pro Ser Ala Leu 
                725                 730                 735     


Ile Thr Thr Asn Met Val Ala Met Glu Ala Ile Cys Pro Glu Gly Ile 
            740                 745                 750         


Ala Arg Leu Ala Asn Ser Gly Ile Asn Val Met Gln Val Ala Asp Leu 
        755                 760                 765             


Gln Ser Ile Asn Ile Ser Gly Asn Gly Phe 
    770                 775             


<210>  56
<211>  5497
<212>  DNA
<213>  Homo sapiens

<400>  56
agttccggcc catgttgttt cggccgagga gccgtcgccg ccatttcaag accgtactag       60

gtagatggtc aattagagtt cccagggttt gaagcctgta actgctgccg ccgctcaagc      120

cctccagagc attgctacgg ctgctgccct tgtactacta cctccaaata cgttcttgct      180

ggtagtggcg gcagcaggac caattacctc ttttttgctc tccctcgaga agctccagat      240

ggcgtcttcc gtgggcaacg tggccgacag cacagaacca acgaaacgta tgctttcctt      300

ccaagggtta gctgagttgg cacatcgaga atatcaggca ggagattttg aggcagctga      360

gagacactgc atgcagctct ggagacaaga gccagacaat actggtgtgc ttttattact      420

ttcatctata cacttccagt gtcgaaggct ggacagatct gctcacttta gcactctggc      480

aattaaacag aacccccttc tggcagaagc ttattcgaat ttggggaatg tgtacaagga      540

aagagggcag ttgcaggagg caattgagca ttatcgacat gcattgcgtc tcaaacctga      600

tttcatcgat ggttatatta acctggcagc cgccttggta gcagcgggtg acatggaagg      660

ggcagtacaa gcttacgtct ctgctcttca gtacaatcct gatttgtact gtgttcgcag      720

tgacctgggg aacctgctca aagccctggg tcgcttggaa gaagccaagg catgttattt      780

gaaagcaatt gagacgcaac cgaactttgc agtagcttgg agtaatcttg gctgtgtttt      840

caatgcacaa ggggaaattt ggcttgcaat tcatcacttt gaaaaggctg tcacccttga      900

cccaaacttt ctggatgctt atatcaattt aggaaatgtc ttgaaagagg cacgcatttt      960

tgacagagct gtggcagctt atcttcgtgc cctaagtttg agtccaaatc acgcagtggt     1020

gcacggcaac ctggcttgtg tatactatga gcaaggcctg atagatctgg caatagacac     1080

ctacaggcgg gctatcgaac tacaaccaca tttccctgat gcttactgca acctagccaa     1140

tgctctcaaa gagaagggca gtgttgctga agcagaagat tgttataata cagctctccg     1200

tctgtgtccc acccatgcag actctctgaa taacctagcc aatatcaaac gagaacaggg     1260

aaacattgaa gaggcagttc gcttgtatcg taaagcatta gaagtcttcc cagagtttgc     1320

tgctgcccat tcaaatttag caagtgtact gcagcagcag ggaaaactgc aggaagctct     1380

gatgcattat aaggaggcta ttcgaatcag tcctaccttt gctgatgcct actctaatat     1440

gggaaacact ctaaaggaga tgcaggatgt tcagggagcc ttgcagtgtt atacgcgtgc     1500

catccaaatt aatcctgcat ttgcagatgc acatagcaat ctggcttcca ttcataagga     1560

ttcagggaat attccagaag ccatagcttc ttaccgcacg gctctgaaac ttaagcctga     1620

ttttcctgat gcttattgta acttggctca ttgcctgcag attgtctgtg attggacaga     1680

ctatgatgag cgaatgaaga agttggtcag tattgtggct gaccagttag agaagaatag     1740

gttgccttct gtgcatcctc atcatagtat gctatatcct ctttctcatg gcttcaggaa     1800

ggctattgct gagaggcacg gcaacctgtg cttagataag attaatgttc ttcataaacc     1860

accatatgaa catccaaaag acttgaagct cagtgatggt cggctgcgtg taggatatgt     1920

gagttccgac tttgggaatc atcctacttc tcaccttatg cagtctattc caggcatgca     1980

caatcctgat aaatttgagg tgttctgtta tgccctgagc ccagacgatg gcacaaactt     2040

ccgagtgaag gtgatggcag aagccaatca tttcattgat ctttctcaga ttccatgcaa     2100

tggaaaagca gctgatcgca tccatcagga tggaattcat atccttgtaa atatgaatgg     2160

ctatactaag ggcgctcgaa atgagctttt tgctctcagg ccagctccta ttcaggcaat     2220

gtggctggga taccctggga cgagtggtgc gcttttcatg gattatatta tcactgatca     2280

ggaaacttcg ccagctgaag ttgctgagca gtattccgag aaattggctt atatgcccca     2340

cacttttttt attggtgatc atgctaatat gttccctcac ctgaagaaaa aagcagtcat     2400

cgattttaag tccaatgggc acatttatga caatcggata gttctgaatg gcatcgacct     2460

caaagcattt cttgatagtc taccagatgt gaaaattgtc aagatgaagt gtcctgatgg     2520

aggagacaat gcagatagca gtaacacagc tcttaatatg cctgttattc ctatgaatac     2580

tattgcagaa gcagttattg aaatgattaa ccgaggacag attcaaataa caattaatgg     2640

attcagtatt agcaatggac tggcaactac tcagatcaac aataaggctg caactggaga     2700

ggaggttccc cgtaccatta ttgtaaccac ccgttctcag tacgggttac cagaagatgc     2760

catcgtatac tgtaacttta atcagttgta taaaattgac ccttctactt tgcagatgtg     2820

ggcaaacatt ctgaagcgtg ttcccaatag tgtactctgg ctgttgcgtt ttccagcagt     2880

aggagaacct aatattcaac agtatgcaca aaacatgggc ctgccccaga accgtatcat     2940

tttttcacct gttgctccta aagaggaaca cgtcaggaga ggccagctgg ctgatgtctg     3000

cttggacact ccactctgta atgggcacac cacagggatg gatgtcctct gggcagggac     3060

ccccatggtg actatgccag gagagactct tgcttctcga gttgcagcat cccagctcac     3120

ttgcttaggt tgtcttgagc ttattgctaa aaacagacaa gaatatgaag acatagctgt     3180

gaagctggga actgatctag aatacctgaa gaaagttcgt ggcaaagtct ggaagcaaag     3240

aatatctagc cctctgttca acaccaaaca atacacaatg gaactagagc ggctctatct     3300

acagatgtgg gagcattatg cagctggcaa caaacctgac cacatgatta agcctgttga     3360

agtcactgag tcagcataaa taaagactgc acaggagaat tacccctata cctgagcctc     3420

aaccttctgg gggaaaggga actagataac atacttctta cttgtctgta cagtaccttg     3480

ttgcagatgg gtgatatata atggtaatag aatagcacag ccagacttgc ttcctgcatg     3540

gtagggagag acacaaaaga tgggaaactg cttttccaca aggaatctcc gtagaatttt     3600

gcggcgacca gatggtgcat aggtctggaa ggtctgatct cccttggtct tccatgggat     3660

ggttagtgtg gaggggagat atagattgtc cggccgcttt gtgattccat ggattgattc     3720

agtcttctgg attttttttt ctttatattt tgggtactgg agcttttaaa aatgtttggt     3780

ttcaggtatt tttattcatg tgaagtgtat atgattctct tgagataagg ttttaagcta     3840

aaatgttact ccctgtttta gtttctgaac tctgacagat tgacagggac tttgctggtg     3900

tagtcttttt ataggtttta taaaccactt gagcctatat cagtcgtttt agtgtctgac     3960

ctaatatttg gagctatcag tgctttgttg atttagatga tgactcaaga ttttttctgg     4020

tccatttccc atttcctttt cttccctgac ccccataccc tcacccttaa aattctcctg     4080

taactcaact aacaaaatca agcctgattc aaaacatcct agggtgtttt aaacacacca     4140

tctggtgcca aatgaagatt tttaggagtg attactaatt atcaagggca cagttgtggt     4200

actgtcattg ataataatat agtttttttt tttttcctaa ttttgacctg tttcaccagt     4260

gttttaccct tgactgcccc ttctatgctg cttccaaaag tgatagtgtg tgtaagattt     4320

ttaccttcct ttctaaagtt tttttttttt ttttttaagt gagtcctgtt cttcctattt     4380

ctttcagcag aaatgaaatc ccaggtaagt ataagtattc aagtatttga tcagtaagtc     4440

acagttatct ccagtgcatt aaataacctt catcaagaaa taggttatag gtaaaatctc     4500

tgaaggatca tctatgtatt caagtaatta ttttttagat aataactgtc ttctggactt     4560

ggtcttgaag tctgtacaga ttcagcctca gtagtagcga actgcactgc tgtttggttt     4620

ggagtacaaa ttagacttat agtcctcctg gaacttgagt tattaaaatc ataggaataa     4680

aattatggga tctcaacaaa gggtcgaggg tttgaggctt aaacaagcca acatatgaat     4740

atatgttttg tctcgctata ctgcacttac gctatccagt tgcaggtaat tttttgtctg     4800

ctagtagtgt tctagattat gtctttccaa agcgctgagg ctgtgcacct attctgtagt     4860

tgcagctgat gcctgaatgt atcctagctg acaaattatt gattaataag aacttgaatt     4920

tctggaagat tcttactgtt aaccaaattt tgagcaagga gtctcaaagg taattctgaa     4980

ccagaattac atgttaatga acagtgtacc ttttaacagt gtaaatcacg gaatatccgt     5040

gaagggattt cttaatttat tttttaccgg ttgattgaaa tatcagttaa aggttgccag     5100

catggttgca gataaactga tgtttgaaat tcgctgaaat acttaatgtg gaataggata     5160

atatacttcc aatgccctca aggctgtgac cttacagcca ttttacatag cacatcattc     5220

ctcctatagg gatgaacttt ttcctggcac gaaaagtagc cgctctggtt gaagctttgc     5280

ttattgtaac aggcttttat ttccaggtaa tatgtcttgg aagacttaat tctgattaga     5340

gatatagata ttactggaaa ctaattgttt tttttctatt gtactctgct ttatcaaaga     5400

agtaaaacat ttaaatcgta ctacagaaat taagatgttg tcttgcgatc cttaataaat     5460

gaatgatttc cctttaatac ggaaaaaaaa aaaaaaa                              5497


<210>  57
<211>  1046
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Ser Ser Val Gly Asn Val Ala Asp Ser Thr Glu Pro Thr Lys 
1               5                   10                  15      


Arg Met Leu Ser Phe Gln Gly Leu Ala Glu Leu Ala His Arg Glu Tyr 
            20                  25                  30          


Gln Ala Gly Asp Phe Glu Ala Ala Glu Arg His Cys Met Gln Leu Trp 
        35                  40                  45              


Arg Gln Glu Pro Asp Asn Thr Gly Val Leu Leu Leu Leu Ser Ser Ile 
    50                  55                  60                  


His Phe Gln Cys Arg Arg Leu Asp Arg Ser Ala His Phe Ser Thr Leu 
65                  70                  75                  80  


Ala Ile Lys Gln Asn Pro Leu Leu Ala Glu Ala Tyr Ser Asn Leu Gly 
                85                  90                  95      


Asn Val Tyr Lys Glu Arg Gly Gln Leu Gln Glu Ala Ile Glu His Tyr 
            100                 105                 110         


Arg His Ala Leu Arg Leu Lys Pro Asp Phe Ile Asp Gly Tyr Ile Asn 
        115                 120                 125             


Leu Ala Ala Ala Leu Val Ala Ala Gly Asp Met Glu Gly Ala Val Gln 
    130                 135                 140                 


Ala Tyr Val Ser Ala Leu Gln Tyr Asn Pro Asp Leu Tyr Cys Val Arg 
145                 150                 155                 160 


Ser Asp Leu Gly Asn Leu Leu Lys Ala Leu Gly Arg Leu Glu Glu Ala 
                165                 170                 175     


Lys Ala Cys Tyr Leu Lys Ala Ile Glu Thr Gln Pro Asn Phe Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Leu Gly Cys Val Phe Asn Ala Gln Gly Glu Ile Trp 
        195                 200                 205             


Leu Ala Ile His His Phe Glu Lys Ala Val Thr Leu Asp Pro Asn Phe 
    210                 215                 220                 


Leu Asp Ala Tyr Ile Asn Leu Gly Asn Val Leu Lys Glu Ala Arg Ile 
225                 230                 235                 240 


Phe Asp Arg Ala Val Ala Ala Tyr Leu Arg Ala Leu Ser Leu Ser Pro 
                245                 250                 255     


Asn His Ala Val Val His Gly Asn Leu Ala Cys Val Tyr Tyr Glu Gln 
            260                 265                 270         


Gly Leu Ile Asp Leu Ala Ile Asp Thr Tyr Arg Arg Ala Ile Glu Leu 
        275                 280                 285             


Gln Pro His Phe Pro Asp Ala Tyr Cys Asn Leu Ala Asn Ala Leu Lys 
    290                 295                 300                 


Glu Lys Gly Ser Val Ala Glu Ala Glu Asp Cys Tyr Asn Thr Ala Leu 
305                 310                 315                 320 


Arg Leu Cys Pro Thr His Ala Asp Ser Leu Asn Asn Leu Ala Asn Ile 
                325                 330                 335     


Lys Arg Glu Gln Gly Asn Ile Glu Glu Ala Val Arg Leu Tyr Arg Lys 
            340                 345                 350         


Ala Leu Glu Val Phe Pro Glu Phe Ala Ala Ala His Ser Asn Leu Ala 
        355                 360                 365             


Ser Val Leu Gln Gln Gln Gly Lys Leu Gln Glu Ala Leu Met His Tyr 
    370                 375                 380                 


Lys Glu Ala Ile Arg Ile Ser Pro Thr Phe Ala Asp Ala Tyr Ser Asn 
385                 390                 395                 400 


Met Gly Asn Thr Leu Lys Glu Met Gln Asp Val Gln Gly Ala Leu Gln 
                405                 410                 415     


Cys Tyr Thr Arg Ala Ile Gln Ile Asn Pro Ala Phe Ala Asp Ala His 
            420                 425                 430         


Ser Asn Leu Ala Ser Ile His Lys Asp Ser Gly Asn Ile Pro Glu Ala 
        435                 440                 445             


Ile Ala Ser Tyr Arg Thr Ala Leu Lys Leu Lys Pro Asp Phe Pro Asp 
    450                 455                 460                 


Ala Tyr Cys Asn Leu Ala His Cys Leu Gln Ile Val Cys Asp Trp Thr 
465                 470                 475                 480 


Asp Tyr Asp Glu Arg Met Lys Lys Leu Val Ser Ile Val Ala Asp Gln 
                485                 490                 495     


Leu Glu Lys Asn Arg Leu Pro Ser Val His Pro His His Ser Met Leu 
            500                 505                 510         


Tyr Pro Leu Ser His Gly Phe Arg Lys Ala Ile Ala Glu Arg His Gly 
        515                 520                 525             


Asn Leu Cys Leu Asp Lys Ile Asn Val Leu His Lys Pro Pro Tyr Glu 
    530                 535                 540                 


His Pro Lys Asp Leu Lys Leu Ser Asp Gly Arg Leu Arg Val Gly Tyr 
545                 550                 555                 560 


Val Ser Ser Asp Phe Gly Asn His Pro Thr Ser His Leu Met Gln Ser 
                565                 570                 575     


Ile Pro Gly Met His Asn Pro Asp Lys Phe Glu Val Phe Cys Tyr Ala 
            580                 585                 590         


Leu Ser Pro Asp Asp Gly Thr Asn Phe Arg Val Lys Val Met Ala Glu 
        595                 600                 605             


Ala Asn His Phe Ile Asp Leu Ser Gln Ile Pro Cys Asn Gly Lys Ala 
    610                 615                 620                 


Ala Asp Arg Ile His Gln Asp Gly Ile His Ile Leu Val Asn Met Asn 
625                 630                 635                 640 


Gly Tyr Thr Lys Gly Ala Arg Asn Glu Leu Phe Ala Leu Arg Pro Ala 
                645                 650                 655     


Pro Ile Gln Ala Met Trp Leu Gly Tyr Pro Gly Thr Ser Gly Ala Leu 
            660                 665                 670         


Phe Met Asp Tyr Ile Ile Thr Asp Gln Glu Thr Ser Pro Ala Glu Val 
        675                 680                 685             


Ala Glu Gln Tyr Ser Glu Lys Leu Ala Tyr Met Pro His Thr Phe Phe 
    690                 695                 700                 


Ile Gly Asp His Ala Asn Met Phe Pro His Leu Lys Lys Lys Ala Val 
705                 710                 715                 720 


Ile Asp Phe Lys Ser Asn Gly His Ile Tyr Asp Asn Arg Ile Val Leu 
                725                 730                 735     


Asn Gly Ile Asp Leu Lys Ala Phe Leu Asp Ser Leu Pro Asp Val Lys 
            740                 745                 750         


Ile Val Lys Met Lys Cys Pro Asp Gly Gly Asp Asn Ala Asp Ser Ser 
        755                 760                 765             


Asn Thr Ala Leu Asn Met Pro Val Ile Pro Met Asn Thr Ile Ala Glu 
    770                 775                 780                 


Ala Val Ile Glu Met Ile Asn Arg Gly Gln Ile Gln Ile Thr Ile Asn 
785                 790                 795                 800 


Gly Phe Ser Ile Ser Asn Gly Leu Ala Thr Thr Gln Ile Asn Asn Lys 
                805                 810                 815     


Ala Ala Thr Gly Glu Glu Val Pro Arg Thr Ile Ile Val Thr Thr Arg 
            820                 825                 830         


Ser Gln Tyr Gly Leu Pro Glu Asp Ala Ile Val Tyr Cys Asn Phe Asn 
        835                 840                 845             


Gln Leu Tyr Lys Ile Asp Pro Ser Thr Leu Gln Met Trp Ala Asn Ile 
    850                 855                 860                 


Leu Lys Arg Val Pro Asn Ser Val Leu Trp Leu Leu Arg Phe Pro Ala 
865                 870                 875                 880 


Val Gly Glu Pro Asn Ile Gln Gln Tyr Ala Gln Asn Met Gly Leu Pro 
                885                 890                 895     


Gln Asn Arg Ile Ile Phe Ser Pro Val Ala Pro Lys Glu Glu His Val 
            900                 905                 910         


Arg Arg Gly Gln Leu Ala Asp Val Cys Leu Asp Thr Pro Leu Cys Asn 
        915                 920                 925             


Gly His Thr Thr Gly Met Asp Val Leu Trp Ala Gly Thr Pro Met Val 
    930                 935                 940                 


Thr Met Pro Gly Glu Thr Leu Ala Ser Arg Val Ala Ala Ser Gln Leu 
945                 950                 955                 960 


Thr Cys Leu Gly Cys Leu Glu Leu Ile Ala Lys Asn Arg Gln Glu Tyr 
                965                 970                 975     


Glu Asp Ile Ala Val Lys Leu Gly Thr Asp Leu Glu Tyr Leu Lys Lys 
            980                 985                 990         


Val Arg Gly Lys Val Trp Lys Gln  Arg Ile Ser Ser Pro  Leu Phe Asn 
        995                 1000                 1005             


Thr Lys  Gln Tyr Thr Met Glu  Leu Glu Arg Leu Tyr  Leu Gln Met 
    1010                 1015                 1020             


Trp Glu  His Tyr Ala Ala Gly  Asn Lys Pro Asp His  Met Ile Lys 
    1025                 1030                 1035             


Pro Val  Glu Val Thr Glu Ser  Ala 
    1040                 1045     


<210>  58
<211>  11242
<212>  DNA
<213>  Homo sapiens

<400>  58
tttttttttt ttttttttga gaaaggggaa tttcatccca aataaaagga atgaagtctg       60

gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc gccgcgctct      120

cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc aacgactatc      180

agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac atcctgctca      240

tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc attaccgagt      300

acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc cccaacctca      360

cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc gagatgacca      420

atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc atcaggattg      480

agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc ctggatgcgg      540

tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac ctgtgtccag      600

ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag tacaactacc      660

gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg aagcgggcgt      720

gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc gcgcctgaca      780

acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt gtgcctgcct      840

gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac ttctgcgcca      900

acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac ggcgagtgca      960

tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac tgcatccctt     1020

gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc attgattctg     1080

ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg ctcattaaca     1140

tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc atcgaggtgg     1200

tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc ttcctaaaaa     1260

accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc tacgtcctcg     1320

acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc atcaaagcag     1380

ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac cgcatggagg     1440

aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg aacaacgggg     1500

agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg tcgaagaatc     1560

gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc atcagcttca     1620

ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg caggatgcct     1680

gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag gacgtggagc     1740

ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac gtcaaggctg     1800

tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag atcttgtaca     1860

ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca tcgaactcct     1920

cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac ctgagttact     1980

acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac aattactgct     2040

ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt gaggaggtca     2100

cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc gcctgcccca     2160

aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa gtctttgaga     2220

atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga gatgtcatgc     2280

aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca gacacctaca     2340

acatcaccga cccggaagag ctggagacag agtacccttt ctttgagagc agagtggata     2400

acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc atcgatatcc     2460

acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc gtctttgcaa     2520

ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg gagccaaggc     2580

ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga ttgattctaa     2640

tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg tccagacagg     2700

aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac tacacagccc     2760

ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg ttcttctatg     2820

tccaggccaa aacaggatat gaaaacttca tccatctgat catcgctctg cccgtcgctg     2880

tcctgttgat cgtgggaggg ttggtgatta tgctgtacgt cttccataga aagagaaata     2940

acagcaggct ggggaatgga gtgctgtatg cctctgtgaa cccggagtac ttcagcgctg     3000

ctgatgtgta cgttcctgat gagtgggagg tggctcggga gaagatcacc atgagccggg     3060

aacttgggca ggggtcgttt gggatggtct atgaaggagt tgccaagggt gtggtgaaag     3120

atgaacctga aaccagagtg gccattaaaa cagtgaacga ggccgcaagc atgcgtgaga     3180

ggattgagtt tctcaacgaa gcttctgtga tgaaggagtt caattgtcac catgtggtgc     3240

gattgctggg tgtggtgtcc caaggccagc caacactggt catcatggaa ctgatgacac     3300

ggggcgatct caaaagttat ctccggtctc tgaggccaga aatggagaat aatccagtcc     3360

tagcacctcc aagcctgagc aagatgattc agatggccgg agagattgca gacggcatgg     3420

catacctcaa cgccaataag ttcgtccaca gagaccttgc tgcccggaat tgcatggtag     3480

ccgaagattt cacagtcaaa atcggagatt ttggtatgac gcgagatatc tatgagacag     3540

actattaccg gaaaggaggg aaagggctgc tgcccgtgcg ctggatgtct cctgagtccc     3600

tcaaggatgg agtcttcacc acttactcgg acgtctggtc cttcggggtc gtcctctggg     3660

agatcgccac actggccgag cagccctacc agggcttgtc caacgagcaa gtccttcgct     3720

tcgtcatgga gggcggcctt ctggacaagc cagacaactg tcctgacatg ctgtttgaac     3780

tgatgcgcat gtgctggcag tataacccca agatgaggcc ttccttcctg gagatcatca     3840

gcagcatcaa agaggagatg gagcctggct tccgggaggt ctccttctac tacagcgagg     3900

agaacaagct gcccgagccg gaggagctgg acctggagcc agagaacatg gagagcgtcc     3960

ccctggaccc ctcggcctcc tcgtcctccc tgccactgcc cgacagacac tcaggacaca     4020

aggccgagaa cggccccggc cctggggtgc tggtcctccg cgccagcttc gacgagagac     4080

agccttacgc ccacatgaac gggggccgca agaacgagcg ggccttgccg ctgccccagt     4140

cttcgacctg ctgatccttg gatcctgaat ctgtgcaaac agtaacgtgt gcgcacgcgc     4200

agcggggtgg ggggggagag agagttttaa caatccattc acaagcctcc tgtacctcag     4260

tggatcttca gaactgccct tgctgcccgc gggagacagc ttctctgcag taaaacacat     4320

ttgggatgtt ccttttttca atatgcaagc agctttttat tccctgccca aacccttaac     4380

tgacatgggc ctttaagaac cttaatgaca acacttaata gcaacagagc acttgagaac     4440

cagtctcctc actctgtccc tgtccttccc tgttctccct ttctctctcc tctctgcttc     4500

ataacggaaa aataattgcc acaagtccag ctgggaagcc ctttttatca gtttgaggaa     4560

gtggctgtcc ctgtggcccc atccaaccac tgtacacacc cgcctgacac cgtgggtcat     4620

tacaaaaaaa cacgtggaga tggaaatttt tacctttatc tttcaccttt ctagggacat     4680

gaaatttaca aagggccatc gttcatccaa ggctgttacc attttaacgc tgcctaattt     4740

tgccaaaatc ctgaactttc tccctcatcg gcccggcgct gattcctcgt gtccggaggc     4800

atgggtgagc atggcagctg gttgctccat ttgagagaca cgctggcgac acactccgtc     4860

catccgactg cccctgctgt gctgctcaag gccacaggca cacaggtctc attgcttctg     4920

actagattat tatttggggg aactggacac aataggtctt tctctcagtg aaggtgggga     4980

gaagctgaac cggcttccct gccctgcctc cccagccccc tgcccaaccc ccaagaatct     5040

ggtggccatg ggccccgaag cagcctggcg gacaggcttg gagtcaaggg gccccatgcc     5100

tgcttctctc ccagccccag ctcccccgcc cgcccccaag gacacagatg ggaaggggtt     5160

tccagggact cagccccact gttgatgcag gtttgcaagg aaagaaattc aaacaccaca     5220

acagcagtaa gaagaaaagc agtcaatgga ttcaagcatt ctaagctttg ttgacatttt     5280

ctctgttcct aggacttctt catgggtctt acagttctat gttagaccat gaaacatttg     5340

catacacatc gtctttaatg tcacttttat aactttttta cggttcagat attcatctat     5400

acgtctgtac agaaaaaaaa aagctgctat tttttttgtt cttgatcttt gtggatttaa     5460

tctatgaaaa ccttcaggtc caccctctcc cctttctgct cactccaaga aacttcttat     5520

gctttgtact agagtgcgtg actttcttcc tcttttcccg gtaatggata cttctatcac     5580

ataatttgcc atgaactgtt ggatgccttt ttataaatac atcccccatc cctgctccca     5640

cctgcccctt tagttgtttt ctaacccgta ggctctctgg gcacgaggca gaaagcaggc     5700

cgggcaccca tcctgagagg gccgcgctcc tctccccagc ctgccctcac agcattggag     5760

cctgttacag tgcaagacat gatacaaact caggtcagaa aaacaaaggt taaatatttc     5820

acacgtcttt gttcagtgtt tccactcacc gtggttgaga agcctcaccc tctctttccc     5880

ttgcctttgc ttaggttgtg acacacatat atatatattt ttttaattct tgggtacaac     5940

agcagtgtta accgcagaca ctaggcattt ggattactat ttttcttaat ggctatttaa     6000

tccttccatc ccacgaaaaa cagctgctga gtccaaggga gcagcagagc gtggtccggc     6060

agggcctgtt gtggccctcg ccacccccct caccggaccg actgacctgt ctttggaacc     6120

agaacatccc aagggaactc cttcgcactg gcgttgagtg ggaccccggg atccaggctg     6180

gcccagggcg gcaccctcag ggctgtgccc gctggagtgc taggtggagg cagcacagac     6240

gccacggtgg cccaagagcc cctttgcttc ttgctggggg accagggctg tggtgctggc     6300

ccactttccc tcggccagga atccaggtcc ttggggccca ggggtcttgt cttgtttcat     6360

ttttagcact tctcaccaga gagatgacag cacaagagtt gcttctggga tagaaatgtt     6420

taggagtaag aacaaagctg ggatacggtg attgctagtt gtgactgaag attcaacaca     6480

gaaaagaaag tttatacggc ttttttgctg gtcagcagtt tgtcccactg ctttctctag     6540

tctctatccc atagcgtgtt ccctttaaaa aaaaaaaaaa ggtattatat gtaggagttt     6600

tcttttaatt tattttgtga taaattacca gtttcaatca ctgtagaaaa gccccattat     6660

gaatttaaat ttcaaggaaa gggtgtgtgt gtgtgtatgt gtggggtgtg tgtgtgtgag     6720

agtgatggga cagttcttga ttttttgggt tttttttccc ccaaacattt atctacctca     6780

ctcttatttt ttatatgtgt atatagacaa aagaatacat ctcacctttc tcagcacctg     6840

acaataggcc gttgatactg gtaacctcat ccacgccaca ggcgccacac ccaggtgatg     6900

cagggggaag ccaggctgta ttccggggtc aaagcaacac taactcacct ctctgctcat     6960

ttcagacagc ttgccttttt ctgagatgtc ctgttttgtg ttgctttttt tgttttgttt     7020

tctatcttgg tttccaccaa ggtgttagat ttctcctcct cctagccagg tggccctgtg     7080

aggccaacga gggcaccaga gcacacctgg gggagccacc aggctgtccc tggctggttg     7140

tctttggaac aaactgcttc tgtgcagatg gaatgaccaa cacatttcgt ccttaagaga     7200

gcagtggttc ctcaggttct gaggagagga aggtgtccag gcagcaccat ctctgtgcga     7260

atccccaggg taaaggcgtg gggcattggg tttgctcccc ttgctgctgc tccatccctg     7320

caggaggctc gcgctgaggc aggaccgtgc ggccatggct gctgcattca ttgagcacaa     7380

aggtgcagct gcagcagcag ctggagagca agagtcaccc agcctgtgcg ccagaatgca     7440

gaggctcctg acctcacagc cagtccctga tagaacacac gcaggagcag agtcccctcc     7500

ccctccaggc tgccctctca acttctccct cacctccttc cctaggggta gacagagatg     7560

taccaaacct tccggctgga aagcccagtg gccggcgccg aggctcgtgg cgtcacgccc     7620

cccccgccag ggctgtacct ccgtctccct ggtcctgctg ctcacaggac agacggctcg     7680

ctcccctctt ccagcagctg ctcttacagg cactgatgat ttcgctggga agtgtggcgg     7740

gcagctttgc ctaagcgtgg atggctcctc ggcaattcca gcctaagtga aggcgctcag     7800

gagcctcctg ctggaacgcg acccatctct cccaggaccc cggggatctt aaggtcattg     7860

agaaatactg ttggatcagg gttttgttct tccacactgt aggtgacccc ttggaataac     7920

ggcctctcct ctcgtgcaca tacctaccgg tttccacaac tggatttcta cagatcattc     7980

agctggttat aagggttttg tttaaactgt ccgagttact gatgtcattt tgtttttgtt     8040

ttatgtaggt agcttttaag tagaaaacac taacagtgta gtgcccatca tagcaaatgc     8100

ttcagaaaca cctcaataaa agagaaaact tggcttgtgt gatggtgcag tcactttact     8160

ggaccaaccc acccaccttg actataccaa ggcatcatct atccacagtt ctagcctaac     8220

ttcatgctga tttctctgcc tcttgatttt tctctgtgtg ttccaaataa tcttaagctg     8280

agttgtggca ttttccatgc aacctccttc tgccagcagc tcacactgct tgaagtcata     8340

tgaaccactg aggcacatca tggaattgat gtgagcatta agacgttctc ccacacagcc     8400

cttccctgag gcagcaggag ctggtgtgta ctggagacac tgttgaactt gatcaagacc     8460

cagaccaccc caggtctcct tcgtgggatg tcatgacgtt tgacatacct ttggaacgag     8520

cctcctcctt ggaagatgga agaccgtgtt cgtggccgac ctggcctctc ctggcctgtt     8580

tcttaagatg cggagtcaca tttcaatggt acgaaaagtg gcttcgtaaa atagaagagc     8640

agtcactgtg gaactaccaa atggcgagat gctcggtgca cattggggtg ctttgggata     8700

aaagatttat gagccaacta ttctctggca ccagattcta ggccagtttg ttccactgaa     8760

gcttttccca cagcagtcca cctctgcagg ctggcagccg aatggcttgc cagtggctct     8820

gtggcaagat cacactgaga tcgatgggtg agaaggctag gatgcttgtc tagtgttctt     8880

agctgtcacg ttggctcctt ccagggtggc cagacggtgt tggccactcc cttctaaaac     8940

acaggcgccc tcctggtgac agtgacccgc cgtggtatgc cttggcccat tccagcagtc     9000

ccagttatgc atttcaagtt tggggtttgt tcttttcgtt aatgttcctc tgtgttgtca     9060

gctgtcttca tttcctgggc taagcagcat tgggagatgt ggaccagaga tccactcctt     9120

aagaaccagt ggcgaaagac actttctttc ttcactctga agtagctggt ggtacaaatg     9180

agaacttcaa gagaggatgt tatttagact gaacctctgt tgccagagat gctgaagata     9240

cagaccttgg acaggtcaga gggtttcatt tttggccttc atcttagatg actggttgcg     9300

tcatttggag aagtgagtgc tccttgatgg tggaatgacc gggtggtggg tacagaacca     9360

ttgtcacagg gatcctggca cagagaagag ttacgagcag cagggtgcag ggcttggaag     9420

gaatgtgggc aaggttttga acttgattgt tcttgaagct atcagaccac atcgaggctc     9480

agcagtcatc cgtgggcatt tggtttcaac aaagaaacct aacatcctac tctggaaact     9540

gatctcggag ttaaggcgaa ttgttcaaga acacaaacta catcgcactc gtcagttgtc     9600

agttctgggg catgacttta gcgttttgtt tctgcgagaa cataacgatc actcattttt     9660

atgtcccacg tgtgtgtgtc cgcatctttc tggtcaacat tgttttaact agtcactcat     9720

tagcgttttc aatagggctc ttaagtccag tagattacgg gtagtcagtt gacgaagatc     9780

tggtttacaa gaactaatta aatgtttcat tgcatttttg taagaacaga ataattttat     9840

aaaatgtttg tagtttataa ttgccgaaaa taatttaaag acactttttt tttctctgtg     9900

tgtgcaaatg tgtgtttgtg atccattttt tttttttttt tttaggacac ctgtttacta     9960

gctagcttta caatatgcca aaaaaggatt tctccctgac cccatccgtg gttcaccctc    10020

ttttcccccc atgctttttg ccctagttta taacaaagga atgatgatga tttaaaaagt    10080

agttctgtat cttcagtatc ttggtcttcc agaaccctct ggttgggaag gggatcattt    10140

tttactggtc atttcccttt ggagtgtagc tactttaaca gatggaaaga acctcattgg    10200

ccatggaaac agccgaggtg ttggagccca gcagtgcatg gcaccgttcg gcatctggct    10260

tgattggtct ggctgccgtc attgtcagca cagtgccatg gacatgggaa gacttgactg    10320

cacagccaat ggttttcatg atgattacag catacacagt gatcacataa acgatgacag    10380

ctatggggca cacaggccat ttgcttacat gcctcgtatc atgactgatt actgctttgt    10440

tagaacacag aagagaccct attttattta aggcagaacc ccgaagatac gtatttccaa    10500

tacagaaaag aatttttaat aaaaactata acatacacaa aaattggttt taaagttgac    10560

tccacttcct ctaactccag tggattgttg gccatgtctc cccaactcca caatatctct    10620

atcatgggaa acacctgggg tttttgcgct acataggaga aagatctgga aactatttgg    10680

gttttgtttt caacttttca tttggatgtt tggcgttgca cacacacatc caccggtgga    10740

agagacgccc ggtgaaaaca cctgtctgct ttctaagcca gtgaggttga ggtgagaggt    10800

ttgccagagt ttgtctacct ctgggtatcc ctttgtctgg gataaaaaaa atcaaaccag    10860

aaggcgggat ggaatggatg caccgcaaat aatgcatttt ctgagttttc ttgttaaaaa    10920

aaaatttttt taagtaagaa aaaaaaaggt aataacatgg ccaatttgtt acataaaatg    10980

actttctgtg tataaattat tcctaaaaaa tcctgtttat ataaaaaatc agtagatgaa    11040

aaaaatttca aaatgttttt gtatattctg ttgtaagaat ttattcctgt tattgcgata    11100

tactctggat tctttacata atggaaaaaa gaaactgtct attttgaatg gctgaagcta    11160

aggcaacgtt agtttctctt actctgcttt tttctagtaa agtactacat ggtttaagtt    11220

aaataaaata attctgtatg ca                                             11242


<210>  59
<211>  1367
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Ile His Leu Ile Ile Ala Leu Pro Val Ala Val 
    930                 935                 940                 


Leu Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His Arg 
945                 950                 955                 960 


Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser Val 
                965                 970                 975     


Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu Trp 
            980                 985                 990         


Glu Val Ala Arg Glu Lys Ile Thr  Met Ser Arg Glu Leu  Gly Gln Gly 
        995                 1000                 1005             


Ser Phe  Gly Met Val Tyr Glu  Gly Val Ala Lys Gly  Val Val Lys 
    1010                 1015                 1020             


Asp Glu  Pro Glu Thr Arg Val  Ala Ile Lys Thr Val  Asn Glu Ala 
    1025                 1030                 1035             


Ala Ser  Met Arg Glu Arg Ile  Glu Phe Leu Asn Glu  Ala Ser Val 
    1040                 1045                 1050             


Met Lys  Glu Phe Asn Cys His  His Val Val Arg Leu  Leu Gly Val 
    1055                 1060                 1065             


Val Ser  Gln Gly Gln Pro Thr  Leu Val Ile Met Glu  Leu Met Thr 
    1070                 1075                 1080             


Arg Gly  Asp Leu Lys Ser Tyr  Leu Arg Ser Leu Arg  Pro Glu Met 
    1085                 1090                 1095             


Glu Asn  Asn Pro Val Leu Ala  Pro Pro Ser Leu Ser  Lys Met Ile 
    1100                 1105                 1110             


Gln Met  Ala Gly Glu Ile Ala  Asp Gly Met Ala Tyr  Leu Asn Ala 
    1115                 1120                 1125             


Asn Lys  Phe Val His Arg Asp  Leu Ala Ala Arg Asn  Cys Met Val 
    1130                 1135                 1140             


Ala Glu  Asp Phe Thr Val Lys  Ile Gly Asp Phe Gly  Met Thr Arg 
    1145                 1150                 1155             


Asp Ile  Tyr Glu Thr Asp Tyr  Tyr Arg Lys Gly Gly  Lys Gly Leu 
    1160                 1165                 1170             


Leu Pro  Val Arg Trp Met Ser  Pro Glu Ser Leu Lys  Asp Gly Val 
    1175                 1180                 1185             


Phe Thr  Thr Tyr Ser Asp Val  Trp Ser Phe Gly Val  Val Leu Trp 
    1190                 1195                 1200             


Glu Ile  Ala Thr Leu Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn 
    1205                 1210                 1215             


Glu Gln  Val Leu Arg Phe Val  Met Glu Gly Gly Leu  Leu Asp Lys 
    1220                 1225                 1230             


Pro Asp  Asn Cys Pro Asp Met  Leu Phe Glu Leu Met  Arg Met Cys 
    1235                 1240                 1245             


Trp Gln  Tyr Asn Pro Lys Met  Arg Pro Ser Phe Leu  Glu Ile Ile 
    1250                 1255                 1260             


Ser Ser  Ile Lys Glu Glu Met  Glu Pro Gly Phe Arg  Glu Val Ser 
    1265                 1270                 1275             


Phe Tyr  Tyr Ser Glu Glu Asn  Lys Leu Pro Glu Pro  Glu Glu Leu 
    1280                 1285                 1290             


Asp Leu  Glu Pro Glu Asn Met  Glu Ser Val Pro Leu  Asp Pro Ser 
    1295                 1300                 1305             


Ala Ser  Ser Ser Ser Leu Pro  Leu Pro Asp Arg His  Ser Gly His 
    1310                 1315                 1320             


Lys Ala  Glu Asn Gly Pro Gly  Pro Gly Val Leu Val  Leu Arg Ala 
    1325                 1330                 1335             


Ser Phe  Asp Glu Arg Gln Pro  Tyr Ala His Met Asn  Gly Gly Arg 
    1340                 1345                 1350             


Lys Asn  Glu Arg Ala Leu Pro  Leu Pro Gln Ser Ser  Thr Cys 
    1355                 1360                 1365         


<210>  60
<211>  16142
<212>  DNA
<213>  Homo sapiens

<400>  60
gcccccgccg cccccgggcc ctgatggact gaatgaaggc tgcctacacc gcctatcgat       60

gcctcaccaa agacctagaa ggctgcgcca tgaacccgga gctgacaatg gaaagtctgg      120

gcactttgca cgggccggcc ggcggcggca gtggcggggg cggcggcggg ggcggcgggg      180

gcggcggcgg gggcccgggc catgagcagg agctgctggc cagccccagc ccccaccacg      240

cgggccgcgg cgccgctggc tcgctgcggg gccctccgcc gcctccaacc gcgcaccagg      300

agctgggcac ggcggcagcg gcggcagcgg cggcgtcgcg ctcggccatg gtcaccagca      360

tggcctcgat cctggacggc ggcgactacc ggcccgagct ctccatcccg ctgcaccacg      420

ccatgagcat gtcctgcgac tcgtctccgc ctggcatggg catgagcaac acctacacca      480

cgctgacacc gctccagccg ctgccaccca tctccaccgt gtctgacaag ttccaccacc      540

ctcacccgca ccaccatccg caccaccacc accaccacca ccaccagcgc ctgtccggca      600

acgtcagcgg cagcttcacc ctcatgcgcg acgagcgcgg gctcccggcc atgaacaacc      660

tctacagtcc ctacaaggag atgcccggca tgagccagag cctgtccccg ctggccgcca      720

cgccgctggg caacgggcta ggcggcctcc acaacgcgca gcagagtctg cccaactacg      780

gtccgccggg ccacgacaaa atgctcagcc ccaacttcga cgcgcaccac actgccatgc      840

tgacccgcgg tgagcaacac ctgtcccgcg gcctgggcac cccacctgcg gccatgatgt      900

cgcacctgaa cggcctgcac cacccgggcc acactcagtc tcacgggccg gtgctggcac      960

ccagtcgcga gcggccaccc tcgtcctcat cgggctcgca ggtggccacg tcgggccagc     1020

tggaagaaat caacaccaaa gaggtggccc agcgcatcac agcggagctg aagcgctaca     1080

gtatccccca ggcgatcttt gcgcagaggg tgctgtgccg gtctcagggg actctctccg     1140

acctgctccg gaatccaaaa ccgtggagta aactcaaatc tggcagggag accttccgca     1200

ggatgtggaa gtggcttcag gagcccgagt tccagcgcat gtccgcctta cgcctggcag     1260

cgtgcaaacg caaagagcaa gaaccaaaca aagacaggaa caattcccag aagaagtccc     1320

gcctggtgtt cactgacctc caacgccgaa cactcttcgc catcttcaag gagaacaaac     1380

gcccgtcaaa ggagatgcag atcaccattt cccagcagct gggcctggag ctcacaaccg     1440

tcagcaactt cttcatgaac gcccggcgcc gcagcctgga gaagtggcaa gacgatctga     1500

gcacaggggg ctcctcgtcc acctccagca cgtgtaccaa agcatgatgg aaggactctc     1560

acttgggcac aagtcacctc caaatgagga caacagatac caaaagaaaa caaaggaaaa     1620

agacaccgga ttcctagctg gggcccttca ctggtgattt gaaagcacaa ttctcttgca     1680

aagaaactta tattctagct gtaatcatag gccaggtgtt cttcttttgt ttttaatggc     1740

tatggagtcc aagtgcaagc tgaaaaatta atctcttaga accagacact gttctctgag     1800

catgctaagc atcccagaaa cccaaatggg gccttcctgg agcgagttaa ttccagtatg     1860

gtgtcaacca agctcgggat tgcttaaaat atcatccatc ccacttcagg tcctgtcagc     1920

ttcttgcagt cagagttcct atgagtaaca ataggagttt ggcctatgta aggactctga     1980

gtttaggctt ccaagataca acaataagag aagaatctag caacgagaat gacctcattt     2040

gctttccaca tgcttagcct cattatacca tgttatgtcc aagttcacag ccacaacatc     2100

agaatggtaa ttactgagca caagttttaa atatggacgt taaaaaaaaa aatccaagga     2160

cctgtttttc caacccagac atcttttcat tgaatgattt agaaagcttt aagttgatcc     2220

agcttacaat tttttttttc tttacctcct ggaaatctca tatggtcttg gatccgtcaa     2280

aaaaaccagt cagttcactt gcgctcaaag tatcaagcac aacaaagata aacagaagtg     2340

aggaaggttc tgggttcact acatctggat tttcaagaca cctattgtga agtcattagg     2400

gaattgatga gaatatggct tcaagcacat tttgcagttt gctacaaatt ctgttgtaca     2460

taatgcagac gcacactcag gaggccaatt taactgttaa cagtgcatgg agcgaatgca     2520

gcattttaaa agatctaggt ttttttaggt cattaatgtg tccttggttg atcagtcatc     2580

tggtccctcc tactgtgtgt tatgaccacc acgtaatcca ttctcgctct ttctgatttg     2640

gggtttttcc tcatccatcc cattagtagg gatgttttct gtgttttcta gcaagaaaaa     2700

aaaatcaatc aatcaaacct gcatacatgt tactcatgac tgtcatctag tcctaaatct     2760

cttctgttgt tgaatcatcc ttgcaaaaca gctgaataca tctggagaaa acacagcaca     2820

ccaaagaagc agaatactgc aaaccaaaga catttatgac ttgtcatttt ctagcctaaa     2880

aatactgtga ttacttttag aaatcagaaa acctctgcaa ctccgaatgg cattcagctc     2940

ttgcatttgg cgcatcatcg ggctgagcgg accagctaca ccaaggacat tagccaagcc     3000

acccagaggg gtggctttgc cacaccagtt gtcaccttcc catagcaagt ggaagagcgc     3060

ccacagaact ctgggagatt gcaaaggtca caatgtgcat atttaccagt gaatggcccc     3120

gggtggggcc acgtgggggt gttcaaagca agccaaacgc tgcaatcatt ctttacagac     3180

acttgagact gactttttta tgaattactt agtcgaaacc aaagaaactt tttctgcacc     3240

tacttctgca acaaacaaaa ctgtcccatt aaaatgaata aataaatccg taaatcaatg     3300

gaaatcacca ccaataagaa ggaagcacgc cagaaaataa acgaaaacaa aaacagggag     3360

acacactgtg ttcaaacaga cctcttggga cattttttgg aagcagattt taaagaaagg     3420

gttgagacaa agatagaaat aaggaagagc ctcagtggct gctgcttcat ttgacaactc     3480

acacggtaat cttaaagctg aagattgtct ttaatttgtg cctatgcagt ttttcaaaag     3540

aacacggaac agagcaacag aaacctcaac agctacaata ccaaagatga ggatttctca     3600

caccttttgt ttcagttcat tatctcctct tgcctggcta aaatactaat agcgccattg     3660

aactgtataa aggtaatcaa ttatgtttct ctgagcaaca aaaggaaagg gccatttatt     3720

tgattttatt gtttcatttc aattttgtct tatggttttt tgccccaaca tggaatctct     3780

caaaagtttc catggactcc aagtttaaga tgttgggata ttgaacagtt ctctctgctc     3840

agcagagggt agggaataac attatcactt gaatgttctt tgcttaaccc ttagacttgg     3900

ttccttctat gttcagagtc tcatcatcag gggaaggaaa gggagtgagg gtcagggata     3960

ggggtcttgg tgatgcatcc tctcccgagc cacagaacca aagagtttat agaggaattt     4020

acagcctcgt tttcatgtga ttgctacatc ctaacagggc ttcatttggg ggtgggggga     4080

aacatgtaaa aataattgcc agtttctact tttctattag ctttttaaaa atcagctgta     4140

aagttgcatt tctaaagaaa gatatatata atatataaaa tacatatata gatcaacttg     4200

acattggtga taaccaaaat tattgctgtc caaattcatg tcttgttttg gtccagtgct     4260

tcatttgcta agtattcggt tcagaatttt tctcatttct catgccattc cagagttaat     4320

ttgccactgt ggatgatttg aagtattcag atctctatgg aagtttctgg gacaggttta     4380

aagtcaagat caagcatttt agcatttaac ctgttgataa atggatccat ggtgtacatg     4440

agttttattt gtattcggag tcatctctat tctatccctc agcctcgatt aaggtggtga     4500

gtgaagtgca tccaacagac tcggcccaga actgggtcct gacagtgggg tgctcatctt     4560

ctgtaactgt tgggaaggct cggtggtcca ttttcaccag ttaaagaata tgaggccagc     4620

ccagaaatct gttctccagg agctgccctg tcccatctgg gtgtgccaga ccccctcagt     4680

gagcaggtcc accaaaggga cttctcacag gggaagccca actcctgttg caatgggttg     4740

atagatttcc tcagggtggt aattaccaat tcgtattttg acaagcctat gtgcaaccac     4800

agctggcact ggggtgggca gtggtgttgg gtgggatggg ggagagtgtc tcaatcctga     4860

agagaaaata taaagcaggt tttggggaga cttctggagt cctgccccta gagagcccca     4920

ttgttgttct ttgtgccccc tcctcattcc ccctatgtgg gtctccctat gcaggagctg     4980

tgagagaatg tgactctcca caatttttat aattcatcct tcctaggaga ttgttcattg     5040

gctcttccct tgtgtccctt tgtcccttgc tcatactcca tgtttccttt gtcaaaggac     5100

taagaaaaga gcatatttca gcagaggagt gttcccatgt gggttgattt caacttgggt     5160

atttctaaaa gagtccttgt gacatgtgtc cagtggaaat ggttgctctt ttccagactg     5220

gattgaggaa tggagcctgt ttgatttggt tagtgattct ttgacatact aatctcagcg     5280

tttgggtctc cagcatcctc tgaagatgtc tagactagta gaggctgcct ttgtgacctg     5340

acattacaac attggtcaaa ccagtcctct gataatcaga agaacatgtc ataattgttt     5400

aaaaaaaaaa aaaaggcaag aatttctctc caaggagctt taataaatgt ctcattccag     5460

ataatgtcat accagagaaa agtgcttgct tttagaaaat tatttacata catatataaa     5520

tatatatgtg tatctataca gttatgtatc aaaattttaa gccctgcaga atttcaattt     5580

gttagaaatc taacagaaaa aaatttctat attgaaaggt aatagaattt aacccagtga     5640

gtttactcaa ggatttttaa atttaagtta ataatttcag agaaaataac catttgggtg     5700

tggttatagt ttagtatcca ttacctcaat ccaaggaaaa ttccaggcat tcctcaacca     5760

tcaggaaaag gtacagtgtg aaggaacagt tctcagccaa atttcacatt cttgaggcaa     5820

cagaaatcaa aacactcaga gccattgagt ggaaaaacaa tttactttat tcctttacac     5880

aaataggctt gcattgtttt tgttttaatg tgattttggt actagggata taattatttc     5940

attccaggaa ataataaaaa aaaacagaca gagccaatac atttcttttt ttaaaggaaa     6000

cagcaacaac aataaaaact cagcaccaat atttaaaagc ttttccaaaa tgtaaaagaa     6060

gtgtttagct tgcaccatgc ataaaggtgc aggctagttg aaccaggaag catggcactt     6120

cctctggaga aatccagaaa gagttgcttc taagctccct tttccccctg caggctcttg     6180

gcaattgtag gctttagcaa atccagaata attttcaatt caagctaaaa taaaatcaac     6240

atttggaatg taaatctgat acacacacac ttttctaagt caaacaacat atttcaaaac     6300

caaaaataaa taccttttag ataatcagtt attttctttg tctatactgg gcacccacct     6360

actagtgcca gtaaattcaa gttgaacaga tttttaaaat cactattatc tgggtatggg     6420

ggaaacttcc ccacttttga aaatgttggt agaattatag gaatgtctgt ttgattatca     6480

ttaccaaagt gtcatgacag tatgcctttg tagtgaactc ggattttcag gagtttgaat     6540

agttggatat tttaaaatct aagaagaaaa ggcctgtttc caatgttgtt gaagaataat     6600

gaactctatt aaaaagtgga gaaaaagata atacatgtgg tcaaggttga ccacaaggcc     6660

caggcacaac taccttggcg ataatcttct agattcgtaa caggttagag ctgacttttt     6720

gtttttgttg ttgctgatgc tgtgtgattc agacttctca gcctaaccag gaagagtaag     6780

tggaaatggt agatgaagaa ggggtagagc tggtgtatct ataactttct gatatttgtc     6840

tgccaaactt gatatattag taattttttt atctttagct aagatcaagt cacccctgaa     6900

acaacaggag attctagttt taaaataagg ccacaaaaat ccttacggaa tgaagaatgg     6960

caccccagtt ggttgtataa gtctcataag ataatgatgt tgattttaaa tatggatgtc     7020

tcaatgcctg ttttctatca atgatttgtt tgtttccaag gtcggggagg gaaagagggg     7080

agggtttatc tgttttagaa agtctcagaa tacttataaa atacagaagt agttattaaa     7140

atatatagga cctcacatag gtagatacag aacttaccat tgaggctgat gggctgttgt     7200

gtgaatcaca caggacctta aatgaggctc attattctca cacaccaaaa tgactctgac     7260

agcctgaagc agttattgct agagcccaag ctttccttgg aggttttgga gttaggttga     7320

ttggaagtaa ccagctaata ccttttctag tggagaaaaa gacattgcta ccagcttgtt     7380

catcccatag aagtcttcca ctctgctcca tttttagcag caagcatttc atgtagcata     7440

aaccttggca gataagtgtg cctaaggttt atacagtctg tccgcttgga tgtatacaaa     7500

tttagataca tattttaaca tgtgttctca tagatgactt tataacaaca cacattacct     7560

ataggtgtct agactgtgta catacaagtg tgtacagaca agcttcatac gtatatactg     7620

taatccgtta caacaaataa attttaaatc atcgtttaac atgtatgtgg tacttctaca     7680

gtgtacattg ttttcattat ttattgtaac attgaaaacc acagtgcagg gaaaacaaaa     7740

gtatcccagc atcttcatcc tgtacacttg gaattaattt catttgggca tatccaagat     7800

aaactcaact ttcaagaaat cttgtatatt atttaatcat ctgtgttagg atgacaccta     7860

tgattgatga cttcggttga atagctttat tctggatttt tcataactaa agctaaatcc     7920

aaagacctga aaaaggacaa aaagaaaaaa aaaaaaagaa aaaacaaaga aaaagaagaa     7980

aaaataataa agtcaagcgc aaactgatgg ggagacagtg ggctctggtt tccaggattg     8040

agacaatggt actgcggtct tggggagact gcgttagcta gtggggagtg gtgatttttt     8100

tcatgcttgt cacatctaaa tggtctttaa catgagaaag ttttagaggt tataatttcc     8160

tgctttgttt ttatttagac tatcaaatga agttatacat gttgtcagtc aaaaaatgaa     8220

gacaccctct gccccacccc acagaatgct ttttatcttg tctctttggg ttatgaccca     8280

acaagctaag taccattaat gtaattaact tatttaaatt agttcctagt acataaatgt     8340

ataggatttg ggtaattatt taatcatcct tccttagttt gattctactc cttgtactta     8400

tttatcaaaa cctagaccaa tggtgcatca gagatgcaaa attctacttg gaatactctt     8460

gaagtttagt ttgctttata aagcagtgaa attctgttac agacagggaa gaaatacagg     8520

ttacaaaaag agaatttggg atattcttcc ctcttaaatt aacttttaaa atagtctaag     8580

taacaatttt taaattattt aacttaagtt cgcagcccca cctggtacca ggcgaacttc     8640

acctcttaat tattgtggcc ctcggagcct tcatattgta acttatttat ttaacttatt     8700

cagcatctgt gaaaggtgca ctgtatagtt tatattttta atttaaaaca acagagagca     8760

ctgcagtttg tttgctgtca gaacaacaga gcaaattttg tggacaagca atgactattc     8820

agcctgaacc tgtgcattca gaaaacataa gctgagaccc tgcttcacca gcctggattt     8880

cggggcttct atacagaaac tggaaaaata aattttaaaa aaatcgtaaa caaaaagaga     8940

gaaaccctta cactagctgc ttccaagaat gaactctgtg tgtatgtaaa gcaacaaaac     9000

aaaaaaggaa aaaaacaaaa agcagaaaaa agaaaaaaaa aatgaaaaac tttctatttc     9060

tagtgagaac caaagaaggc tacctcactg actttttcca tttgtaattt taatcgtgtt     9120

gatgacacca aagataccaa agatttcttt ctctgtgcgg tctgcatttt gcttgtgctc     9180

ttttataatt tgaacgattt tctctgacat atggtatgta cagccacagc tcagataccc     9240

caaagaaata attatctatg cgacggcggc tgctaatttg gaaagggata ttttctgtgt     9300

ttctcttata tgtttgctgt ctgctcgaca tgttcaagat gcgagttcag atgctgctgt     9360

aattggattc cttaaattct gattacaaat tgaggaagga aactggttgg aaatggcctt     9420

cagtcctagc catggcctct atccccgctg ggacctgtca cagtaaagac tgccaattac     9480

tgaaccacag aagctctgac cattgagtag ttgagctgga agagacctta ggaatcattt     9540

agtccaagcc ccggtggccc agaggaatga aatagttatc caaatcaaat aactcttgag     9600

agtgaaagcc cacacatgcc tcctggttcc tgccccagtg ctccgcttat tgtacagtgc     9660

tacctctgca tgagagcggt cccacattga caaataggat ggtggcaatc ctttagcaat     9720

gagcagggac tggggtttat ctcttaacat tttcagctgt aaaattagtc acaagcattt     9780

tcagtgtccc attagtacat agtcacatat ggtcggttgc ttcgtgaagg tggcctgtct     9840

tgaaatacta gggctcatac gggatttttg ccctaggaaa aacatgttga tcccaatgat     9900

gtgatcactt ttgaaccttt ccattacaaa gcattgtata gataactttt taattcagta     9960

ggaggagaaa gttcattctt ggcctgttgg ctttgattat tatgggtact ttaaagtcag    10020

tatttatcaa gaaagggaac ttgaccacca ttggcacatg tgacatttaa gctcttcagc    10080

cttttccttt ttagttgtag gtgtttacat ttcatttcta agccaactct gtatttatga    10140

gagaagttta agccttacat catttgatac taaagggtta tttgtggtaa atgaaaaatg    10200

accccaaaat tacagaggaa tatgccagtt taagaaatgg ctacttaaag ttgcttctct    10260

ctttccttct tactcatgaa attaattggt cttcttcaag tttctttaga ttccattaaa    10320

tgattaaatc actattaaga gccattcatc aacgtgattt gtgtgttagc caatgaatct    10380

gtctcagctt ttgaccaaat gggttttaga caaatgcaaa gatctgcctc tagtccatat    10440

ggctcttttt gagtgctagt attttgcatt tcacataatg tagttatttt gagcttttaa    10500

agagagcatt tagacaaaga agcaaagaga ggaagggacc aatcaactca tcagttccat    10560

gcatcaacaa agcatagcta gtagaggaat ataaatgaca gattgacaaa ctgtaggaaa    10620

cactgttact ctctttctga agttttcaag caccatccta tgtgaaagtt ccctcctgtc    10680

caaacaagct caaggcccat cttctcccta tacaaggcaa acctgtaagg ccttccttcc    10740

aaagagtaca ttgctttggt tttcttccta aattcctatt ggaattagaa ctctcagaat    10800

ccctgggaga cagagcaaag atgacttaat tcattgagca gcagagctcc ctataagtga    10860

acatcacctt ccccatcttt cctactgcca cacccatacg agagaggatc tagaaagagc    10920

gatggcagcc tgaacacaga aaacatcccc acttggcaga cctctcctca gcaatccccc    10980

cagcctcatg cttcacttgc aaagtgtgac ataaccacgg gacgagtgcc ttgcttgaac    11040

caaagcaacg atttagccag tctggacctc tctgtgcttt ttttaattct tcctgtgaat    11100

acctcagctt caactgggcc tccatacagt cagttggtgg gcttattgta ctgtggtgct    11160

ttgcaatgca accctgcaaa gaacaagatt tgtactaata ccaaaggttc tttctctatg    11220

tctcctcctc tgcctccctc gttcttccct tttttctagt tcttcacggt tccaaagctt    11280

tactatgaac ctgggcatgt tggcaatgca gaccgcgcaa ttccttaccg aattttctca    11340

gatatacctc atagacaata gtgtttagag taatgttatt atagcgtatg taataaatta    11400

ttcactgttt cttttggtaa ctgtgattta aaaaaagaaa aaagaaaaaa aagctttata    11460

cgttttaggt tgtgcttttg taatagatga aaaaaggtgc gcttaaaaag aaaatgtatg    11520

tttttttccc cctttggatt ttatttatgc tggattgggg aaagttgcag aatgagccca    11580

aagtttacag tttcatattt tgctgaagaa acaatctgtg ttcatttgct ctgttgaaaa    11640

gaataattat tttctacatt tgtgccactt ggtctgaaca attaattgtt ccgtgttaac    11700

agtgtagtat tatgattagc aactgccaat cagtgctata attttatgca tgaggctaaa    11760

aatttagcag tgtgatgcat tgtggtctta atagcaacat ttttcatttt gaactagatc    11820

ttcccctttg gttcaatgga ctttatttat gcatgggcgc ctattgtttg ttagcagttg    11880

tggaacagtt gtgtatacat taaactgtga aaatgtacac agttcagcct cagacggtgg    11940

taatattggt tttattggga gatgtgtcac ctcgaaaata ccctttacat ctgttgggat    12000

ctgaaaatga gtcacattga attgggttcc agctttataa tgagaaacgt tattcctaat    12060

ttttgagtta gccaatttgc attccacaaa ttgggatcct cataacccaa atatatcacc    12120

gtatgtgaga gggatttgaa agcgagtatt gaaaaactca cctttgcata tttaatttcc    12180

accaaaagga gttattttgg ctttatgctc atgaacttag acctaactgg ccatgtatat    12240

gtagatgcaa attcatctag ctgtggccct ctttgatctc tgcttgggaa tggctatttt    12300

tgactatgcg tggtttcttc tcgtattttg tgatcaggtc agctcccagt agaaactcaa    12360

atggcatcaa tattactaac tcttctctgc ccacttctct tttgtccact ctcctagaca    12420

ttcccaccaa ctgttccagt gatttgggca aaaatacgca gccatttccc aaaacttcac    12480

atgtgcagct atcatggctg tccctcccta gacttggagg tgactctcac ttaattttta    12540

cctgcccaac aatgttccat ctaccatcta aaaggtaata taagaagaag ttttgaaacc    12600

cactttagga aaaccatctt ctttaaatcc ttcaattatc tgaggcctct atatgtcaaa    12660

actatttttc agttgcaggg gattgggcaa acttgttctt tcttatactt gggttcaaag    12720

acccattctc cagtttcata tttcccaaac caaaatgctt gacataaagc caaatcaact    12780

gccaagcaca ctttattttg cataggagta tgcagcctag ggaaccttgg ttgaaaagca    12840

gcagtctgct atgcaaaata ttggaaatca ctgacagtgt agcattcata ttatctgtca    12900

atgagggtat attgggaacg tgctctcgtg aataataaaa agcaacatat ttttatttgg    12960

ccttataaat taggttgtgg taatgtaaac tttgatatat agtcttttta tttttctctt    13020

attaatctgc caaagatggg aacagataca agaatttttc aaattggctt ttgtaagaca    13080

attgatgatt gtaatagtgt ttaatcttcc agaaagcttt atatgttgtt ccacaataaa    13140

attgatattt gtttcagcaa agttttcctg acactcacaa acccacaaac tgttcctctt    13200

aatgcagata ttgtagaatc tacaaagttc aaatccattt ttgatccaaa gaaagtagag    13260

gagtatttga gacatgagtg tacccagccc tttttttaat cacaggcaat gcatgggtct    13320

ggctggttac actttgccaa gaagacttgt cttatgaaac ccaaggtata ttttgttatg    13380

ccattttatg tccttttctt ttaacattgt ggaaagtggt atgttgaatc aagtgtaagc    13440

tgagttttcc agacaactga agtagctaca tcatgaatgt tattttgtta ttaaagggtt    13500

tttactcagt gctttgtgcc aatggatgtc cttttccttg gagacacata actacaaaat    13560

tacctcagct tggcctggtt ttctctcctg ccctcttggg gaaacatggg cctggcctgg    13620

gaaaaggcag gtcatgggct ggaaggtagg ttttggtact aggaagaaat ctctgtatct    13680

gtcagcttta aagagaactg ggccaaaaat ctctaacctc actctctctg gactccaaca    13740

cttccctgca atcctttggt cttgagcatg tgccagcatg aaggcagact ccagttcata    13800

catgaaaggc aagaaaaaga aaatagtaac cttgaatctt ctgtgggcca ccaggcactc    13860

acctttcccc accttgcaca ctatccagtc aaggctattg cagcccatct ggtggcttta    13920

catgggacat taccaaaggc ttcttcctcc atcctggggt tgcaaaggat ccaggtcccc    13980

tccatccagt ggggctcttc cacatcagaa gtccccctcc caccatcctc tgcatcctgt    14040

ttagctatcc catctatacc ttttggagat gattatttag aaaacaaaga aaggtatgga    14100

atggggtttc ctattgtttg ctaggttata ttttagcaat tctcaattct ttgatctgga    14160

aaaatacaag agggaaaagg agaccccact atctccctgt gctttgctcc catctcaggg    14220

ggcaggggca gtgcacattg cctatgctgt tgatctgtct tgggcgacag gctgaatcac    14280

agctattgcc ccagccaaaa acatggccca tcaatgccta ctttatctct gcttgaaaat    14340

cctattcaaa aagttgtaga gtttgaggtt tttatccccc catatccttt gctttggtcc    14400

agtttggcct ttagcataag agtcagcttt atctctagga aagttttttc agattatgac    14460

aaggaacctg ccacctggga agaaaagagt ccgaagacta gcaatcggat aggtagtcat    14520

accattaaca gatacttcct tgaaggtaga atattatttc ctttctttac agttttgtgt    14580

tacacaagtc caagtggtgc cagcaaactt cttaccgtga aatgttgtaa aacacctggc    14640

atactgaaat ttctgaaaca aaaacacaag ctccacattg ataacttgat aaataaccac    14700

taaagtttag atgcagggac tgagatgata caggcaaaat cttggtgttg gtttctcttt    14760

taattcgtat cttcgatcac ctaacctttc tcaatccaag agcagttcag tcttttctcc    14820

ccaagtctag gatgccaaag agcatcatag gaaaagataa ttagggattg accagcattt    14880

caattagttc tcttcttcat ctttgcattt ctcaaaagtg ttctcctgga ccagagggaa    14940

agagctggtc catttttttt cattctttct attcaaattt ttccacccag acaatacttt    15000

attaacacag atactgtaga tccttccttg gtcagtgaat tattacaaga ggagctatcc    15060

ttccaccaaa gtgagtgaaa acaagttcca gtatcttttc ttccatccag ttttgttctc    15120

agaatccaag tcagtcctgg gtcttttctc actttagacc ctggcctcag atgtgtttat    15180

tcttgctatt taaaaatacc tttaaatttc acatgctggc ctgcagaact tgcatccttt    15240

gttctatact gttgactgct tgatggtatt gaaaggtgac tataatgagg gaagaaagga    15300

ggaggtaaag agagaagaat ttgtcccaga tctgtttaaa gtttcaaaat ttaaaaaggg    15360

acccattaaa ttatgggaaa atggctatag agtgtgagcc tccgttgacc atatgctcaa    15420

agaccgtact ctgccacctg ccttccaggt agctattcta gaaactcagt cctttgtgga    15480

aacccaacta ccttttaaaa gtctctttcc agattccaaa aggacaagag atcagagagt    15540

cacatatacg cctcttgttt tattttcttg ctttcacggg tattattgcc aagaaaatcg    15600

tagggaaaaa ctttaaactt ttcttttcag ttgatccctt tgacatcacc tctcatgttt    15660

aaaatcagga aaacacaccc ctaaaatttg cactctcttc cgttttgaaa aagaaaaccc    15720

acacacaaat gcacactatt accgtctttc accctgcgct atatttccaa agtgtattat    15780

aatccagata ttgccccatc tcaaacatgt taagtcagac tgtgctgaaa gactttccag    15840

ggacggtcaa cagggtatat gttcagtggc tgccctgaaa tcctggtggg gatgaggatc    15900

acgcttcatc atcaagggga tgcccatccc ctgataagct cccagtcctt ttggaagatt    15960

tctttgaatg ttaattgcat tttcagtttt gctcatttcc caccccaatg ttttgtctgc    16020

aacatcgctt acactggatt ctttctattt ttattcctat cattaaatgg tagtgctgta    16080

aattctgcaa ttaatgttaa ataaactgct ttaattcatt gaaaaaaaaa aaaaaaaaaa    16140

aa                                                                   16142


<210>  61
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Lys Ala Ala Tyr Thr Ala Tyr Arg Cys Leu Thr Lys Asp Leu Glu 
1               5                   10                  15      


Gly Cys Ala Met Asn Pro Glu Leu Thr Met Glu Ser Leu Gly Thr Leu 
            20                  25                  30          


His Gly Pro Ala Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Pro Gly His Glu Gln Glu Leu Leu Ala Ser 
    50                  55                  60                  


Pro Ser Pro His His Ala Gly Arg Gly Ala Ala Gly Ser Leu Arg Gly 
65                  70                  75                  80  


Pro Pro Pro Pro Pro Thr Ala His Gln Glu Leu Gly Thr Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ser Arg Ser Ala Met Val Thr Ser Met Ala Ser 
            100                 105                 110         


Ile Leu Asp Gly Gly Asp Tyr Arg Pro Glu Leu Ser Ile Pro Leu His 
        115                 120                 125             


His Ala Met Ser Met Ser Cys Asp Ser Ser Pro Pro Gly Met Gly Met 
    130                 135                 140                 


Ser Asn Thr Tyr Thr Thr Leu Thr Pro Leu Gln Pro Leu Pro Pro Ile 
145                 150                 155                 160 


Ser Thr Val Ser Asp Lys Phe His His Pro His Pro His His His Pro 
                165                 170                 175     


His His His His His His His His Gln Arg Leu Ser Gly Asn Val Ser 
            180                 185                 190         


Gly Ser Phe Thr Leu Met Arg Asp Glu Arg Gly Leu Pro Ala Met Asn 
        195                 200                 205             


Asn Leu Tyr Ser Pro Tyr Lys Glu Met Pro Gly Met Ser Gln Ser Leu 
    210                 215                 220                 


Ser Pro Leu Ala Ala Thr Pro Leu Gly Asn Gly Leu Gly Gly Leu His 
225                 230                 235                 240 


Asn Ala Gln Gln Ser Leu Pro Asn Tyr Gly Pro Pro Gly His Asp Lys 
                245                 250                 255     


Met Leu Ser Pro Asn Phe Asp Ala His His Thr Ala Met Leu Thr Arg 
            260                 265                 270         


Gly Glu Gln His Leu Ser Arg Gly Leu Gly Thr Pro Pro Ala Ala Met 
        275                 280                 285             


Met Ser His Leu Asn Gly Leu His His Pro Gly His Thr Gln Ser His 
    290                 295                 300                 


Gly Pro Val Leu Ala Pro Ser Arg Glu Arg Pro Pro Ser Ser Ser Ser 
305                 310                 315                 320 


Gly Ser Gln Val Ala Thr Ser Gly Gln Leu Glu Glu Ile Asn Thr Lys 
                325                 330                 335     


Glu Val Ala Gln Arg Ile Thr Ala Glu Leu Lys Arg Tyr Ser Ile Pro 
            340                 345                 350         


Gln Ala Ile Phe Ala Gln Arg Val Leu Cys Arg Ser Gln Gly Thr Leu 
        355                 360                 365             


Ser Asp Leu Leu Arg Asn Pro Lys Pro Trp Ser Lys Leu Lys Ser Gly 
    370                 375                 380                 


Arg Glu Thr Phe Arg Arg Met Trp Lys Trp Leu Gln Glu Pro Glu Phe 
385                 390                 395                 400 


Gln Arg Met Ser Ala Leu Arg Leu Ala Ala Cys Lys Arg Lys Glu Gln 
                405                 410                 415     


Glu Pro Asn Lys Asp Arg Asn Asn Ser Gln Lys Lys Ser Arg Leu Val 
            420                 425                 430         


Phe Thr Asp Leu Gln Arg Arg Thr Leu Phe Ala Ile Phe Lys Glu Asn 
        435                 440                 445             


Lys Arg Pro Ser Lys Glu Met Gln Ile Thr Ile Ser Gln Gln Leu Gly 
    450                 455                 460                 


Leu Glu Leu Thr Thr Val Ser Asn Phe Phe Met Asn Ala Arg Arg Arg 
465                 470                 475                 480 


Ser Leu Glu Lys Trp Gln Asp Asp Leu Ser Thr Gly Gly Ser Ser Ser 
                485                 490                 495     


Thr Ser Ser Thr Cys Thr Lys Ala 
            500                 


