                         SEQUENCE LISTING

<110>  Jefferies, Wilfred
 
<120>  P97 FRAGMENTS WITH TRANSFER ACTIVITY

<130>  BIOA-004/01WO 315702-2013

<150>  US 61/515,792
<151>  2011-08-05

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Lys Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn 
                


<210>  2
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg Ser Glu Asp Tyr 
1               5                   10                  15      


Glu Leu Leu Cys Pro Asn 
            20          


<210>  3
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Ala Arg Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln 
1               5                   10                  15      


Ile Pro Pro His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr 
            20                  25                  30          


Val Tyr Gly Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His 
        35                  40                  45              


Asn Lys Asn 
    50      


<210>  4
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu 
1               5                   10                  15      


Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr 
            20                  25                  30          


Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met 
        35                  40                  45              


Ser Ser Gln Gln Cys 
    50              


<210>  5
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Lys Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn 
            580                 585     


<210>  6
<211>  637
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Lys Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn 
625                 630                 635         


<210>  7
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg Ser Glu Asp Tyr 
1               5                   10                  15      


Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val Ser Gln Phe Ala 
            20                  25                  30          


Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val Met Val Arg Pro 
        35                  40                  45              


Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp Lys Ala Gln Asp 
    50                  55                  60                  


Leu Phe Gly Asp Asp His Asn Lys Asn 
65                  70              


<210>  8
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg Ser Glu Asp Tyr 
1               5                   10                  15      


Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val Ser Gln Phe Ala 
            20                  25                  30          


Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val Met Val Arg Pro 
        35                  40                  45              


Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp Lys Ala Gln Asp 
    50                  55                  60                  


Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys Met Phe Asp Ser 
65                  70                  75                  80  


Ser Asn Tyr His Gly Gln Asp Leu Leu Phe Lys Asp Ala Thr Val Arg 
                85                  90                  95      


Ala Val Pro Val Gly Glu Lys Thr Thr Tyr Arg Gly Trp Leu Gly Leu 
            100                 105                 110         


Asp Tyr Val Ala Ala Leu Glu Gly Met Ser Ser Gln Gln Cys 
        115                 120                 125     


<210>  9
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Ala Arg Ala Glu Val Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln 
1               5                   10                  15      


Ile Pro Pro His Ala Val Met Val Arg Pro Asp Thr Asn Ile Phe Thr 
            20                  25                  30          


Val Tyr Gly Leu Leu Asp Lys Ala Gln Asp Leu Phe Gly Asp Asp His 
        35                  40                  45              


Asn Lys Asn Gly Phe Lys Met Phe Asp Ser Ser Asn Tyr His Gly Gln 
    50                  55                  60                  


Asp Leu Leu Phe Lys Asp Ala Thr Val Arg Ala Val Pro Val Gly Glu 
65                  70                  75                  80  


Lys Thr Thr Tyr Arg Gly Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu 
                85                  90                  95      


Glu Gly Met Ser Ser Gln Gln Cys 
            100                 


<210>  10
<211>  14
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  Primer

<400>  10
gcggacttcc tcgg                                                         14


<210>  11
<211>  13
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  Primer

<400>  11
tcgcgagctt cct                                                          13


<210>  12
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  12

Gly Met Glu Val Arg Trp Cys Ala Thr Ser Asp Pro Glu Gln His Lys 
1               5                   10                  15      


Cys Gly Asn Met Ser Glu Ala Phe Arg Glu Ala Gly Ile Gln Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Arg Gly Thr Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Ala Ala Gln Glu Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Glu Val Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Ser Ser His Val Thr Ile Asp Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly Arg Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Ser Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Ala Gly Glu Thr 
145                 150                 155                 160 


Ser Tyr Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


Glu Gly Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Lys Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Gln Ala Leu Leu Ser Gln Asp Phe Glu Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Val Thr Glu Trp Arg Gln Cys His Leu Ala Arg 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Ala Asp Thr Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Arg Leu Leu Asn Glu Gly Gln Arg Leu Phe Ser His Glu Gly 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Glu Ala Tyr Gly Gln Lys Asp Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Ser Glu Leu Val Pro Ile Ala Thr Gln Thr 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly His Glu Tyr Leu His Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro Pro Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Thr Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Arg 
        355                 360                 365             


Arg Gln Arg Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Lys Ser Pro 
    370                 375                 380                 


Gln His Cys Met Glu Arg Ile Gln Ala Glu Gln Val Asp Ala Val Thr 
385                 390                 395                 400 


Leu Ser Gly Glu Asp Ile Tyr Thr Ala Gly Lys Lys Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu His Tyr Ala Pro Glu Asp Ser Ser Asn Ser Tyr 
            420                 425                 430         


Tyr Val Val Ala Val Val Arg Arg Asp Ser Ser His Ala Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Ala Gly Phe Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Asp Val Pro Val Gly Ala Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Glu Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ser Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Gln Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Asn Ser Gln Glu Arg Tyr Tyr Gly Tyr Arg Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu Asn Ala Gly Asp Val Ala Phe Val Arg His Thr Thr Val Phe 
545                 550                 555                 560 


Asp Asn Thr Asn Gly His Asn Ser Glu Pro Trp Ala Ala Glu Leu Arg 
                565                 570                 575     


Ser Glu Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Ser Gln Phe Ala Ala Cys Asn Leu Ala Gln Ile Pro Pro His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Lys 
625                 630                 635                 640 


Met Phe Asp Ser Ser Asn Tyr His Gly Gln Asp Leu Leu Phe Lys Asp 
                645                 650                 655     


Ala Thr Val Arg Ala Val Pro Val Gly Glu Lys Thr Thr Tyr Arg Gly 
            660                 665                 670         


Trp Leu Gly Leu Asp Tyr Val Ala Ala Leu Glu Gly Met Ser Ser Gln 
        675                 680                 685             


Gln Cys 
    690 


<210>  13
<211>  690
<212>  PRT
<213>  Mus musculus

<400>  13

Val Met Glu Val Gln Trp Cys Thr Ile Ser Asp Ala Glu Gln Gln Lys 
1               5                   10                  15      


Cys Lys Asp Met Ser Glu Ala Phe Gln Gly Ala Gly Ile Arg Pro Ser 
            20                  25                  30          


Leu Leu Cys Val Gln Gly Asn Ser Ala Asp His Cys Val Gln Leu Ile 
        35                  40                  45              


Lys Glu Gln Lys Ala Asp Ala Ile Thr Leu Asp Gly Gly Ala Ile Tyr 
    50                  55                  60                  


Glu Ala Gly Lys Glu His Gly Leu Lys Pro Val Val Gly Glu Val Tyr 
65                  70                  75                  80  


Asp Gln Asp Ile Gly Thr Ser Tyr Tyr Ala Val Ala Val Val Arg Arg 
                85                  90                  95      


Asn Ser Asn Val Thr Ile Asn Thr Leu Lys Gly Val Lys Ser Cys His 
            100                 105                 110         


Thr Gly Ile Asn Arg Thr Val Gly Trp Asn Val Pro Val Gly Tyr Leu 
        115                 120                 125             


Val Glu Ser Gly His Leu Ser Val Met Gly Cys Asp Val Leu Lys Ala 
    130                 135                 140                 


Val Gly Asp Tyr Phe Gly Gly Ser Cys Val Pro Gly Thr Gly Glu Thr 
145                 150                 155                 160 


Ser His Ser Glu Ser Leu Cys Arg Leu Cys Arg Gly Asp Ser Ser Gly 
                165                 170                 175     


His Asn Val Cys Asp Lys Ser Pro Leu Glu Arg Tyr Tyr Asp Tyr Ser 
            180                 185                 190         


Gly Ala Phe Arg Cys Leu Ala Glu Gly Ala Gly Asp Val Ala Phe Val 
        195                 200                 205             


Lys His Ser Thr Val Leu Glu Asn Thr Asp Gly Asn Thr Leu Pro Ser 
    210                 215                 220                 


Trp Gly Lys Ser Leu Met Ser Glu Asp Phe Gln Leu Leu Cys Arg Asp 
225                 230                 235                 240 


Gly Ser Arg Ala Asp Ile Thr Glu Trp Arg Arg Cys His Leu Ala Lys 
                245                 250                 255     


Val Pro Ala His Ala Val Val Val Arg Gly Asp Met Asp Gly Gly Leu 
            260                 265                 270         


Ile Phe Gln Leu Leu Asn Glu Gly Gln Leu Leu Phe Ser His Glu Asp 
        275                 280                 285             


Ser Ser Phe Gln Met Phe Ser Ser Lys Ala Tyr Ser Gln Lys Asn Leu 
    290                 295                 300                 


Leu Phe Lys Asp Ser Thr Leu Glu Leu Val Pro Ile Ala Thr Gln Asn 
305                 310                 315                 320 


Tyr Glu Ala Trp Leu Gly Gln Glu Tyr Leu Gln Ala Met Lys Gly Leu 
                325                 330                 335     


Leu Cys Asp Pro Asn Arg Leu Pro His Tyr Leu Arg Trp Cys Val Leu 
            340                 345                 350         


Ser Ala Pro Glu Ile Gln Lys Cys Gly Asp Met Ala Val Ala Phe Ser 
        355                 360                 365             


Arg Gln Asn Leu Lys Pro Glu Ile Gln Cys Val Ser Ala Glu Ser Pro 
    370                 375                 380                 


Glu His Cys Met Glu Gln Ile Gln Ala Gly His Thr Asp Ala Val Thr 
385                 390                 395                 400 


Leu Arg Gly Glu Asp Ile Tyr Arg Ala Gly Lys Val Tyr Gly Leu Val 
                405                 410                 415     


Pro Ala Ala Gly Glu Leu Tyr Ala Glu Glu Asp Arg Ser Asn Ser Tyr 
            420                 425                 430         


Phe Val Val Ala Val Ala Arg Arg Asp Ser Ser Tyr Ser Phe Thr Leu 
        435                 440                 445             


Asp Glu Leu Arg Gly Lys Arg Ser Cys His Pro Tyr Leu Gly Ser Pro 
    450                 455                 460                 


Ala Gly Trp Glu Val Pro Ile Gly Ser Leu Ile Gln Arg Gly Phe Ile 
465                 470                 475                 480 


Arg Pro Lys Asp Cys Asp Val Leu Thr Ala Val Ser Gln Phe Phe Asn 
                485                 490                 495     


Ala Ser Cys Val Pro Val Asn Asn Pro Lys Asn Tyr Pro Ser Ala Leu 
            500                 505                 510         


Cys Ala Leu Cys Val Gly Asp Glu Lys Gly Arg Asn Lys Cys Val Gly 
        515                 520                 525             


Ser Ser Gln Glu Arg Tyr Tyr Gly Tyr Ser Gly Ala Phe Arg Cys Leu 
    530                 535                 540                 


Val Glu His Ala Gly Asp Val Ala Phe Val Lys His Thr Thr Val Phe 
545                 550                 555                 560 


Glu Asn Thr Asn Gly His Asn Pro Glu Pro Trp Ala Ser His Leu Arg 
                565                 570                 575     


Trp Gln Asp Tyr Glu Leu Leu Cys Pro Asn Gly Ala Arg Ala Glu Val 
            580                 585                 590         


Asp Gln Phe Gln Ala Cys Asn Leu Ala Gln Met Pro Ser His Ala Val 
        595                 600                 605             


Met Val Arg Pro Asp Thr Asn Ile Phe Thr Val Tyr Gly Leu Leu Asp 
    610                 615                 620                 


Lys Ala Gln Asp Leu Phe Gly Asp Asp His Asn Lys Asn Gly Phe Gln 
625                 630                 635                 640 


Met Phe Asp Ser Ser Lys Tyr His Ser Gln Asp Leu Leu Phe Lys Asp 
                645                 650                 655     


Ala Thr Val Arg Ala Val Pro Val Arg Glu Lys Thr Thr Tyr Leu Asp 
            660                 665                 670         


Trp Leu Gly Pro Asp Tyr Val Val Ala Leu Glu Gly Met Leu Ser Gln 
        675                 680                 685             


Gln Cys 
    690 


