
                                SEQUENCE LISTING

<110> Isis Pharmaceuticals, Inc.
      Indiana University Research and Technology Corporation
      Merrill D. Benson
      Barbara Kluve-Beckerman
      Adam Mullick
      Susan M. Freier

<120> MODULATION OF INFLAMMATORY RESPONSES BY
      SAA1 AND SAA2

<130> BIOL0160WO


<150> 61/522,199
<151> 2011-08-10

<160> 19

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 607
<212> DNA
<213> Mus musculus

<400> 1
atagatcacc agatctgccc aggagacacc aggatgaagc tactcaccag cctggtcttc 60
tgctccctgc tcctgggagt ctgccatgga gggttttttt catttgttca cgaggctttc 120
caaggggctg gggacatgtg gcgagcctac actgacatga aggaagctaa ctggaaaaac 180
tcagacaaat acttccatgc tcgggggaac tatgatgctg ctcaaagggg tcccggggga 240
gtctgggctg ctgagaaaat cagtgatgga agagaggcct ttcaggaatt cttcggcaga 300
ggacatgagg acaccattgc tgaccaggaa gccaacagac atggccgcag tggcaaagac 360
cccaattact acagacctcc tggactgcct gacaaatact gagcgtcctc ctattagctc 420
agtaggttgt gctgggggcc tgagggtggg gtctgggctt cttcctacct aggaacactg 480
aagatgctct ctggggaaac attgtatatc tctcatgtgt gtatcccaca agggtttcag 540
aactgagtta ctcttgcagt agtaactgct tgaggaggag agggtaataa acagaaactt 600
ggaagtg                                                           607

<210> 2
<211> 607
<212> DNA
<213> Mus musculus

<400> 2
atagaccacc agatctgccc aggagacacc agcaggatga agctactcac cagcctggtc 60
ttctgctccc tgctcctggg agtctgccat ggagggtttt tttcatttat tggggaggct 120
ttccaagggg ctggagacat gtggcgagcc tacactgaca tgaaggaagc tggctggaaa 180
gatggagaca aatacttcca tgctcggggg aactatgatg ctgcccaaag gggtcccggg 240
ggagtctggg ctgctgagaa aatcagtgat gcaagagaga gctttcagga attcttcggc 300
agaggacacg aggacaccat ggctgaccag gaagccaaca gacatggccg cagtggcaaa 360
gaccccaatt actacagacc tcctggactg cctgccaaat actgagagtc ctcctattag 420
ttcagaaggc tgtgttgggg tcctgagggt ggggtctggg cttcctatct aggaacactg 480
aagatgctct ctggggcaac atagtatacc tctcatgtgt gtatcccaca aggtttcaga 540
atggagttac tcgagcagta gtaactgctt gaggaggaga gggtaataaa caggaacttg 600
gaagtgg                                                           607

<210> 3
<211> 4823
<212> DNA
<213> Homo sapien

<400> 3
tctagactga gggtgaagga gcttccaggg cacacatgag acatggcagg gctaggctgc 60
tagttttatt ttgttttgtt ttagacacag ggtcttgctc tgttaaccag gctggagtgc 120
agtggcgtga ttatagctca ctgcagcctt gacctcctgg gtctcccaca atccttccgc 180
ttcagcctct tgagtagctg ggactgcagg tgcacactac cacacccggt ccatttattt 240
ttatatttcg tagagacaag atcttacagt tttgcacaga gtgatcttaa actcttgacc 300
ccaagtgatc ctcctgcctt ggcctccaaa agcattggga ttataggagt gagccactgt 360
gctggaccta gtctgtcagc tttgaagctt tagatatgaa ctcagaggga cttcatttca 420
gaggcatctg ccatgtggcc cagcagagcc catcctgagg aaatgactgg tagagtcagg 480
agctggcttc aaagctgccc tcacttcaca ccttccagca gcccaggtgc cgccatcacg 540
gggctcccac tctcaactcc gcagcctcag ccccctcaat gctgaggagc agagctggtc 600
tcctgccctg acagctgcca ggcacatctt gttccctcag gttgcacaac tgggataaat 660
gacccgggat gaagaaacca ctggcatcca ggaacttgtc ttagaccgtt ttgtagggga 720
aatgacctgc agggactttc cccagggacc acatccagct tttcttccct cccaagaaac 780
cagcagggaa ggctcagtat aaatagcagc caccgctccc tggcaggcag ggacccgcag 840
ctcagctaca gcacagatca ggtgaggagc acaccaagga gtgattttta aaacttactc 900
tgttttctct ttcccaacaa gattatcatt tcctttaaaa aaaatagtta tcctggggca 960
tacagccata ccattctgaa ggtgtcttat ctcctctgat ctagagaggt aagcagggtc 1020
gggcctggta gtacttggat gggagaacac ctgggaatac caggtgctaa aggctttaag 1080
aataaaaaat aatgatcctg ctttgtgttt atgggatgtt gagttctgtg cggggcagag 1140
ggaacacacg gtaaatgcgt tatggggaat tataggctac ttgagggagt gacagtctgg 1200
tggtaactcc tgccttcctc catcagtgcc acgttggctc ctcttatgca gtcaggcttc 1260
agggctgatg ggttcagaac cgagggcttc tggctctgag tgacggtcct gctgcaaggt 1320
ttcctagatg agccactgag actctaataa gatccagtga aataaccagg ctctcgtcgg 1380
aatataagtc ccaagggaag ctgtgccagt cttgtgggcg actgcctgac ttctcctttc 1440
atttcagcac catgaagctt ctcacgggcc tggttttctg ctccttggtc ctgggtgtca 1500
gcagccgaag cttcttttcg ttccttggcg aggcttttga tggtaaggct tcagaaggtt 1560
tgcaggattt ctgaagagaa acatcaccct ggacctgata aactggggaa aatgatgctt 1620
tcggaaggct gcttttgaac cacagagttg ctagtgtctg cgttgctgag gcctgccagg 1680
aactagggtt tgctgggttg cctgtctcga gtctttcaga gctgctggga atatcccttt 1740
cccgtagtgc agcttctcag gatgtgttaa gtggatggat cacatttcag aagccgctgc 1800
aaggtgtatc aaaaacacat atcctgagcc gtaaggaacg gggcatccag taacaacgca 1860
cacggggtat ttttgggctt ccttaagatt tgagccgctg ccttaggttg tgctgcccaa 1920
tgtgcctggg gagctgctaa acagattaga gagtcgagga ttgttgtcag ttactcagag 1980
aaagaacaat catcctttcc aggagcacct gagctgtttg ttttgagtag aagatgcaaa 2040
ataaggcctg caattggtat aaaatgtccc tcagcataaa tcgcatagga gtatgactaa 2100
ggctgttgac tcttctgtct tctttctcct tcctccttcg atttcctagt tggataatgt 2160
acagggccct ttagcctcgc tctgtcaggg gctcccttcc tggtttgttc tgtttccatt 2220
cttccttctc cagccttctt gacaagagct gggaactaac gtgcctcaag cccccacaag 2280
gaccacagca ttttctcatt tagtttcaga atgactctgt gacgcaatct tcctctcttg 2340
gaaggtgaga aagctgatct tggaaggtga gaaagctgag acttagagca gctgaagcca 2400
atgcccaggg acttactgcc agtcagcagg tggcagggca gaggtttgag cccggctgtg 2460
cttgaggtca gggctcttgc caggtagacg catcactgac cacctcctag aggttgatgg 2520
ttatgaatct caggcacacc ttggcatcac ctgaaatacc catgccttca actccccagc 2580
agagtctgca gaaactggcc tggggtgtgg cctgggcact gggtactttc agtttctctc 2640
tgggtgatta gaaagtgcag ccaaggctca cgcctgtaat tccagcactt tgggaggcca 2700
aggtggatga atcacttgag gtcatgagtt ccggagcagc ctggccaaca tggtgaaacc 2760
ccgtctctac taaaaatact aaaatgtagc caggcgtggt ggcaggcacc tgtaatccca 2820
gctactcagg aggctgaagc acgagaatca cttcaacccg agaagcagag gttgcagtga 2880
ctagagatcg caccagtgtc ctccaacctg ggtgacagag cgagactcca tctaaaaaaa 2940
atgaaaaaga aagtgcagcc aaggcagagc accactgccc tattgcttcc tcaagcaacc 3000
cacagcatca gtacagccta ctaagaaagt atttagggac ttttatgctc ctaacagtca 3060
ctggaactca cgtcacaatg acgtgtattc catttgcaag aatatatact ttaggtcggg 3120
gtgcggtggc tcacgcctgt aatcccagca ctttgggagg ccaaggcagg gggatcacga 3180
ggtcaggagt tcgagaccag cctgaccaac atggtgaaat ccccgtctct actaaaaata 3240
caaaaattag ccaggcgtga tggcgcatgc ctgtaatctc agctactcag gaggctgatc 3300
ggaagaagaa tctcttgaac ctggaggtgg aggttgcgat gagctgagat agcaccactg 3360
caactccagc ctgggcgaca gaactttagt agtcagggca gaagtactct gtgtctgcca 3420
cctttctcag catcagtatt ccatgtcact acctcattca tacacactcc tggatcttat 3480
cataggcagc ttcattctat agcagtggct cttcaccagg gcacttgaag aagccaacta 3540
ggataaagga atgtgcttct caacccatgg tatccaaggc tgctatgatc acaggctgaa 3600
agcttgaagt cagtggaaga tttgtccttc ctcattcccc tctaaggtgt tgttggagtc 3660
tttatgttct cctgatgtcc cttctgcctt tcctttcctt tccaggggct cgggacatgt 3720
ggagagccta ctctgacatg agagaagcca attacatcgg ctcagacaaa tacttccatg 3780
ctcgggggaa ctatgatgct gccaaaaggg gacctggggg tgcctgggct gcagaagtga 3840
tcaggtaact ggagctcctg ggacgttagg gctgggtgag cagagcttgc ctgccttgga 3900
cagtcaggag ggagacgagc tccttgtgga gaagttagag gctgcggccc ctcctcctct 3960
tgccctctct ctgcctctgt gctcagtgtg agggtctgag tggatggtag gagtgagtga 4020
ttcctcatcc tccctctctg ggtgctgttc atccagccta ggggtgccca gcctggctga 4080
atggggtggt gcccagtgtt ttcatccctc cttccttggc ctttctgggc tcctctctga 4140
gccctccctt ggaacaggga gaatgggagg gtgggctatt gctcactggc ctgattatta 4200
atctccttct tgcctgcctt gattacagcg atgccagaga gaatatccag agattctttg 4260
gccatggtgc ggaggactcg ctggctgatc aggctgccaa tgaatggggc aggagtggca 4320
aagaccccaa tcacttccga cctgctggcc tgcctgagaa atactgagct tcctcttcac 4380
tctgctctca ggagatctgg ctgtgaggcc ctcagggcag ggatacaaag cggggagagg 4440
gtacacaatg ggtatctaat aaatacttaa gaggtggaat tgtggaaact gggtgttata 4500
ctttgtggta tagactgcct gtttagtatg aagggcgatc catgcacatc taagtgaacg 4560
tggaggctgg gtgggtggga gacgactcct gggcacacag ggcatcctgg gcatccctga 4620
ggcaaggaca tgatgagttc agtggccacc cccacaggat cccaggggct tcagcagatc 4680
ccacccctta ccccatgtga gcagctgccc agtgagtctg taggaacccg agccacattc 4740
ccagtgagtt caactgcacc ccggcacgtt ttgctagcac ctcaatggag agctccttgc 4800
ttgcagcttt ggcttgtgca ccc                                         4823

<210> 4
<211> 716
<212> DNA
<213> Homo sapien

<400> 4
aggctcagta taaatagcag ccaccgctcc ctggcaggca gggacccgca gctcagctac 60
agcacagatc aggtgaggag cacaccaagg agtgattttt aaaacttact ctgttttctc 120
tttcccaaca agattatcat ttcctttaaa aaaaatagtt atcctggggc atacagccat 180
accattctga aggtgtctta tctcctctga tctagagagc accatgaagc ttctcacggg 240
cctggttttc tgctccttgg tcctgggtgt cagcagccga agcttctttt cgttccttgg 300
cgaggctttt gatggggctc gggacatgtg gagagcctac tctgacatga gagaagccaa 360
ttacatcggc tcagacaaat acttccatgc tcgggggaac tatgatgctg ccaaaagggg 420
acctgggggt gcctgggctg cagaagtgat cagcgatgcc agagagaata tccagagatt 480
ctttggccat ggtgcggagg actcgctggc tgatcaggct gccaatgaat ggggcaggag 540
tggcaaagac cccaatcact tccgacctgc tggcctgcct gagaaatact gagcttcctc 600
ttcactctgc tctcaggaga tctggctgtg aggccctcag ggcagggata caaagcgggg 660
agagggtaca caatgggtat ctaataaata cttaagaggt ggaatttgtg gaaact     716

<210> 5
<211> 569
<212> DNA
<213> Homo sapien

<400> 5
aggctcagta taaatagcag ccaccgctcc ctggcaggca gggacccgca gctcagctac 60
agcacagatc agcaccatga agcttctcac gggcctggtt ttctgctcct tggtcctggg 120
tgtcagcagc cgaagcttct tttcgttcct tggcgaggct tttgatgggg ctcgggacat 180
gtggagagcc tactctgaca tgagagaagc caattacatc ggctcagaca aatacttcca 240
tgctcggggg aactatgatg ctgccaaaag gggacctggg ggtgcctggg ctgcagaagt 300
gatcagcgat gccagagaga atatccagag attctttggc catggtgcgg aggactcgct 360
ggctgatcag gctgccaatg aatggggcag gagtggcaaa gaccccaatc acttccgacc 420
tgctggcctg cctgagaaat actgagcttc ctcttcactc tgctctcagg agatctggct 480
gtgaggccct cagggcaggg atacaaagcg gggagagggt acacaatggg tatctaataa 540
atacttaaga ggtggaattt gtggaaact                                   569

<210> 6
<211> 526
<212> DNA
<213> Homo sapien

<400> 6
cagctacagc acagatcagc accatgaagc ttctcacggg cctggttttc tgctccttgg 60
tcctgagtgt cagcagccga agcttctttt cgttccttgg cgaggctttt gatggggctc 120
gggacatgtg gagagcctac tctgacatga gagaagccaa ttacatcggc tcagacaaat 180
acttccatgc tcgggggaac tatgatgctg ccaaaagggg acctgggggt gcctgggccg 240
cagaagtgat cagcaatgcc agagagaata tccagagact cacaggccat ggtgcggagg 300
actcgctggc cgatcaggct gccaataaat ggggcaggag tggcagagac cccaatcact 360
tccgacctgc tggcctgcct gagaaatact gagcttcctc ttcactctgc tctcaggaga 420
cctggctatg agccctcggg gcagggattc aaagttagtg aggtctatgt ccagagaagc 480
tgagatatgg catataatag gcatctaata aatgcttaag aggtgg                526

<210> 7
<211> 3596
<212> DNA
<213> Homo sapien

<400> 7
cctctcttgt tcccataggt tacacaactg ggataaatga cccgggatga agaaaccacc 60
ggcatccagg aacttgtctt agaccagttt gtaggggaaa tgacctgcag ggactttccc 120
cagggaccac atccagcttt tcttccctcc caagagacca gcaaggctca ctataaatag 180
cagccacctc tccctggcag acagggaccc gcagctcagc tacagcacag atcaggtgag 240
gagcacacca aggagtgatt tttaaaactt actctgtttt ctctttccca acaagattat 300
catttccttt aaaaaaaata gttatcctgg ggcatacagc cataccattc tgaaggtgtc 360
ttatctcctc tgatctagag aggtaagcag ggtcgggcct ggtagtactt ggatgggaga 420
acacctggga ataccaggtg ctaaaggctt taagaataaa aaataatgat cctgctttgt 480
gtttatccca tgttgagttc tgtgcggggc agagggaaca cacggtaaat gcgttatggg 540
gaattatagg ctacttgagg gagtgacagt ctggtggtaa ctcctgcctt cctccatcag 600
tgccacgttg gcatcctctt atgcagtcag gcttcagggc tgatgggttc agaaccgagg 660
gcttctggct ctgagtgagg tcctgctgca aggtttccta gatgagccac tgagactcta 720
ataagatcca gtggaaataa ccaggctctc gtcggaatat aagtcccaag ggaagctgtg 780
ccagtcttgt gggcgactgc ctgacttctc ctttcatttc agcaccatga agcttctcac 840
gggcctggtt ttctgctcct tggtcctgag tgtcagcagc cgaagcttct tttcgttcct 900
tggcgaggct tttgatggta aggcttcaga aggtttgcag gatttctgaa gagaaacatc 960
gccctggacc tgataaactg gggaaaatga tgctttcgga aggctgcttt tgaaccacag 1020
agttgctagt gtctgcgttg ctgaggcctg ccaggaacta gggtttgctg ggttgcctgt 1080
ctcgagtctt tcagagctgc tgggaatatc ccctttcccc gtagtgcagc ttctcaggat 1140
gtgttaagtg gatggatcac atttcagaag ccgctgcaag gtgtatcaaa aacacatctc 1200
ctgagccgta agggacgggg catccagtaa caacgcacac ggggtatttt tgggcttcct 1260
taagatttga gccgctgcct taggttgtgc tgcccaatgt gcctggggag ctgctaaaca 1320
gattagagag tcgaggattg ttgtcagtta ctcagagaaa gaacaatcat cctttccagg 1380
agcacctgag ctgtttgttt tgagtagaag atgcaaaata aggcctgcaa ttggtataaa 1440
atgtccctca gcataaatcg cataggagta tgactaaggc tgttgactct tctgtcttct 1500
ttctcctttc ctccttcgat ttcctagttg gataatgtac agggctcttt agcctcgctc 1560
tgtcaggggc tcccttcctg gtttgttctg tttccattct tccttctcca gccttcttga 1620
caagagctgg gaactaacgt gcctcaagcc cccacaagga ccacagcatt ttctcatcta 1680
gtttcagaat gactctgtga ggcaggcatc ccttctgtga aggtgagaaa gctgagactt 1740
agagcagctg aggccaatgc ccagggactt actgccagtc agcaggtggc agggcagagg 1800
tttgagcccg gctgtgcttg aggtcagggc tcttgccagg tagacgcatc actgaccacc 1860
tcccagaggt tgatggttat gaatctcagg cacaccttgg catcacctga actacccatg 1920
ccttcaactc cccagcagag tctgcagaaa ctggcctggg gtgtggcctg ggcactggga 1980
ctttcagttt ctctctgggt gattagaaag tgcagccaag gctcacgcct gtaattccag 2040
cactttggga ggccaaggtg gatgaatcac ttgaggtcat gagttccgga gcagcctggc 2100
caacatggtg aaaccctgtg tctactaaaa atatgaaaat gtagccaggc gtggtggcag 2160
gcacctgtaa tcccagctac tcaggaggct gaagcaggaa aatcacttga acccgggaag 2220
cgaagttgta gtgagttaca ttgctccagt gtgctccagc ctgggtgaca gagtgagact 2280
ccgtctaaaa aaataaaaaa gaaaaagaaa gtgcaaccac ggcggagaac cgctgctcta 2340
ttgcttcctc aagcaaccca cagtatcagt acagcctact gagaaagtgt ttagggactt 2400
ttatgctcct aacagtcact ggaactcagg tcacaatgac atgtattcca tttgcaagaa 2460
tatatacttt agtagtcagg gcagaagtac tctgtgtctg ccacctttct cagcatcagt 2520
attccatgtc accacctcat tcatatacac tcctggatct tatcataggc agcttcattc 2580
tatagcagtg gctcttcacc agggcacttg aagaagccaa ctaggataaa ggaatgtgct 2640
tctcaaccca tggtatccaa ggctgctatg atcacaggct gaaagcttga agtcagtgga 2700
agatttgtcc ttctttcatt cccctctaag gtgttgttgg agtctttatg ttctcctgat 2760
gtcccttctg cctttccttt cctttccagg ggctcgggac atgtggagag cctactctga 2820
catgagagaa gccaattaca tcggctcaga caaatacttc catgctcggg ggaactatga 2880
tgctgccaaa aggggacctg ggggtgcctg ggctgcagaa gtgatcaggt aactggagct 2940
cctgggacgt tagggctggg tgagcagagc ttgcctgcct tggacagtca ggagggagac 3000
gagctccttg tggagaagtt agaggctgtg gtccctcctc ttcttgccct ctctctgcct 3060
ctgtgctcag tgtgagggtc tgagtggatg gtaggagtga gtgattcctc cccctccccc 3120
tctgggtgct gttcatccag cctaggggtg cccagcctgt ctgaatgggg cagtgcccag 3180
gcagggtcag tgttttcact cctccttcct tggcctttct gggctcctct ctgagccctc 3240
ccttggaacg gggagaatgg gagggtgagc tgttgctcac tggcctgatg attaatctcc 3300
ttcttgcctg cctggactac agcaatgcca gagagaatat ccagagactc acaggccgtg 3360
gtgcggagga ctcgctggcc gatcaggctg ccaataaatg gggcaggagt ggcagagacc 3420
ccaatcactt ccgacctgct ggcctgcctg agaaatactg agcttcctct tcactctgct 3480
ctcaggagac ctggctatga ggccctcggg gcagggatac aaagttagtg aggtctatgt 3540
ccagagaagc tgagatatgg catataatag gcatctaata aatgcttaag aggtgg     3596

<210> 8
<211> 545
<212> DNA
<213> Homo sapien

<400> 8
agggacccgc agctcagcta cagcacagat cagcaccatg aagcttctca cgggcctggt 60
tttctgctcc ttggtcctga gtgtcagcag ccgaagcttc ttttcgttcc ttggcgaggc 120
ttttgatggg gctcgggaca tgtggagagc ctactctgac atgagagaag ccaattacat 180
cggctcagac aaatacttcc atgctcgggg gaactatgat gctgccaaaa ggggacctgg 240
gggtgcctgg gctgcagaag tgatcagcaa tgccagagag aatatccaga gactcacagg 300
ccgtggtgcg gaggactcgc tggccgatca ggctgccaat aaatggggca ggagtggcag 360
agaccccaat cacttccgac ctgctggcct gcctgagaaa tactgagctt cctcttcact 420
ctgctctcag gagacctggc tatgaggccc tcggggcagg gatacaaagt tagtgaggtc 480
tatgtccaga gaagctgaga tatggcatat aataggcatc taataaatgc ttaagaggtg 540
gaaaa                                                             545

<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 9
agagcatctt cagtgttcct                                             20

<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 10
tgtgggatac acacatgaga                                             20

<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 11
cttgtgggat acacacatga                                             20

<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 12
tgtttattac cctctcctcc                                             20

<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 13
gctgaccagg aagccaacag                                             20

<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 14
caggcagtcc aggaggtctg                                             20

<210> 15
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Probe

<400> 15
catggccgca gtggcaaaga cc                                          22

<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 16
cctcctggac tgcctgacaa                                             20

<210> 17
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 17
cccagcacaa cctactgagc ta                                          22

<210> 18
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Probe

<400> 18
actgagcgtc ctcc                                                   14

<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic oligonucleotide

<400> 19
ccttccctga aggttcctcc                                             20
