                         SEQUENCE LISTING

<110>  RAMOT at Tel-Aviv University Ltd.
 
<120>  ZYMOXINS AND METHODS OF USING THE SAME

<130>  RAMOT 043 PCT

<150>  61/525855
<151>  2011-08-22

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  110
<212>  PRT
<213>  Escherichia coli

<400>  1

Met Val Ser Arg Tyr Val Pro Asp Met Gly Asp Leu Ile Trp Val Asp 
1               5                   10                  15      


Phe Asp Pro Thr Lys Gly Ser Glu Gln Ala Gly His Arg Pro Ala Val 
            20                  25                  30          


Val Leu Ser Pro Phe Met Tyr Asn Asn Lys Thr Gly Met Cys Leu Cys 
        35                  40                  45              


Val Pro Cys Thr Thr Gln Ser Lys Gly Tyr Pro Phe Glu Val Val Leu 
    50                  55                  60                  


Ser Gly Gln Glu Arg Asp Gly Val Ala Leu Ala Asp Gln Val Lys Ser 
65                  70                  75                  80  


Ile Ala Trp Arg Ala Arg Gly Ala Thr Lys Lys Gly Thr Val Ala Pro 
                85                  90                  95      


Glu Glu Leu Gln Leu Ile Lys Ala Lys Ile Asn Val Leu Ile 
            100                 105                 110 


<210>  2
<211>  35
<212>  PRT
<213>  Escherichia coli

<400>  2

Arg Lys Glu Pro Val Phe Thr Leu Ala Glu Leu Val Asn Asp Ile Thr 
1               5                   10                  15      


Pro Glu Asn Leu His Glu Asn Ile Asp Trp Gly Glu Pro Lys Asp Lys 
            20                  25                  30          


Glu Val Trp 
        35  


<210>  3
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide

<400>  3

Ser Gly Leu Arg Ser Phe Leu Val Asn Met Cys Val Ala Thr Val Leu 
1               5                   10                  15      


Thr Ala Gly Ala Tyr Leu Cys Tyr Arg Phe Leu Phe Asn Ser Asn Thr 
            20                  25                  30          


<210>  4
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide

<400>  4

Ser Glu Glu Asp Asp Thr Thr Val Cys Cys Ser Met Ser Tyr Ser Trp 
1               5                   10                  15      


Thr Gly Ala Leu 
            20  


<210>  5
<211>  197
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide

<400>  5

Met Val Ser Arg Tyr Val Pro Asp Met Gly Asp Leu Ile Trp Val Asp 
1               5                   10                  15      


Phe Asp Pro Thr Lys Gly Ser Glu Gln Ala Gly His Arg Pro Ala Val 
            20                  25                  30          


Val Leu Ser Pro Phe Met Tyr Asn Asn Lys Thr Gly Met Cys Leu Cys 
        35                  40                  45              


Val Pro Cys Thr Thr Gln Ser Lys Gly Tyr Pro Phe Glu Val Val Leu 
    50                  55                  60                  


Ser Gly Gln Glu Arg Asp Gly Val Ala Leu Ala Asp Gln Val Lys Ser 
65                  70                  75                  80  


Ile Ala Trp Arg Ala Arg Gly Ala Thr Lys Lys Gly Thr Val Ala Pro 
                85                  90                  95      


Glu Glu Leu Gln Leu Ile Lys Ala Lys Ile Asn Val Leu Ile Ser Glu 
            100                 105                 110         


Glu Asp Asp Thr Thr Val Cys Cys Ser Met Ser Tyr Ser Trp Thr Gly 
        115                 120                 125             


Ala Leu Arg Lys Glu Pro Val Phe Thr Leu Ala Glu Leu Val Asn Asp 
    130                 135                 140                 


Ile Thr Pro Glu Asn Leu His Glu Asn Ile Asp Trp Gly Glu Pro Lys 
145                 150                 155                 160 


Asp Lys Glu Val Trp Ser Gly Leu Arg Ser Phe Leu Val Asn Met Cys 
                165                 170                 175     


Val Ala Thr Val Leu Thr Ala Gly Ala Tyr Leu Cys Tyr Arg Phe Leu 
            180                 185                 190         


Phe Asn Ser Asn Thr 
        195         


<210>  6
<211>  226
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide

<400>  6

Ser Gly Arg Thr Gln Ile Ser Ser Met Val Ser Arg Tyr Val Pro Asp 
1               5                   10                  15      


Met Gly Asp Leu Ile Trp Val Asp Phe Asp Pro Thr Lys Gly Ser Glu 
            20                  25                  30          


Gln Ala Gly His Arg Pro Ala Val Val Leu Ser Pro Phe Met Tyr Asn 
        35                  40                  45              


Asn Lys Thr Gly Met Cys Leu Cys Val Pro Cys Thr Thr Gln Ser Lys 
    50                  55                  60                  


Gly Tyr Pro Phe Glu Val Val Leu Ser Gly Gln Glu Arg Asp Gly Val 
65                  70                  75                  80  


Ala Leu Ala Asp Gln Val Lys Ser Ile Ala Trp Arg Ala Arg Gly Ala 
                85                  90                  95      


Thr Lys Lys Gly Thr Val Ala Pro Glu Glu Leu Gln Leu Ile Lys Ala 
            100                 105                 110         


Lys Ile Asn Val Leu Ile Gly Gly Ser Ser Glu Glu Asp Asp Thr Thr 
        115                 120                 125             


Val Cys Cys Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Gly Gly Gly 
    130                 135                 140                 


Gly Ser Arg Lys Glu Pro Val Phe Thr Leu Ala Glu Leu Val Asn Asp 
145                 150                 155                 160 


Ile Thr Pro Glu Asn Leu His Glu Asn Ile Asp Trp Gly Glu Pro Lys 
                165                 170                 175     


Asp Lys Glu Val Trp Ser Ser Gly Gly Ser Gly Gly Gly Ser Gly Ser 
            180                 185                 190         


Gly Gly Ser Gly Leu Arg Ser Phe Leu Val Asn Met Cys Val Ala Thr 
        195                 200                 205             


Val Leu Thr Ala Gly Ala Tyr Leu Cys Tyr Arg Phe Leu Phe Asn Ser 
    210                 215                 220                 


Asn Thr 
225     


<210>  7
<211>  433
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide

<400>  7

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Met Val Ser Arg 
225                 230                 235                 240 


Tyr Val Pro Asp Met Gly Asp Leu Ile Trp Val Asp Phe Asp Pro Thr 
                245                 250                 255     


Lys Gly Ser Glu Gln Ala Gly His Arg Pro Ala Val Val Leu Ser Pro 
            260                 265                 270         


Phe Met Tyr Asn Asn Lys Thr Gly Met Cys Leu Cys Val Pro Cys Thr 
        275                 280                 285             


Thr Gln Ser Lys Gly Tyr Pro Phe Glu Val Val Leu Ser Gly Gln Glu 
    290                 295                 300                 


Arg Asp Gly Val Ala Leu Ala Asp Gln Val Lys Ser Ile Ala Trp Arg 
305                 310                 315                 320 


Ala Arg Gly Ala Thr Lys Lys Gly Thr Val Ala Pro Glu Glu Leu Gln 
                325                 330                 335     


Leu Ile Lys Ala Lys Ile Asn Val Leu Ile Ser Glu Glu Asp Asp Thr 
            340                 345                 350         


Thr Val Cys Cys Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Arg Lys 
        355                 360                 365             


Glu Pro Val Phe Thr Leu Ala Glu Leu Val Asn Asp Ile Thr Pro Glu 
    370                 375                 380                 


Asn Leu His Glu Asn Ile Asp Trp Gly Glu Pro Lys Asp Lys Glu Val 
385                 390                 395                 400 


Trp Ser Gly Leu Arg Ser Phe Leu Val Asn Met Cys Val Ala Thr Val 
                405                 410                 415     


Leu Thr Ala Gly Ala Tyr Leu Cys Tyr Arg Phe Leu Phe Asn Ser Asn 
            420                 425                 430         


Thr 
    


<210>  8
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide

<400>  8

Ser Gly Arg Thr Gln Ile Ser Ser 
1               5               


<210>  9
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide

<400>  9

Gly Gly Gly Gly Ser 
1               5   


<210>  10
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide

<400>  10

Ser Ser Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly Gly 
1               5                   10              


<210>  11
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  11
ggactcagat ctcgagcatg gtaagccgat acgtacccg                              39


<210>  12
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  12
gagcaacata cggtcgtgtc atcttcttca gagcttccgc caatcagtac gttaattttg       60

gctttaatg                                                               69


<210>  13
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  13
cttttcgcga cccgccaccg cccagcgcac cagtccagga gtagctcata gagcaacata       60

cggtcgtgt                                                               69


<210>  14
<211>  70
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  14
gttttccggc gtgatgtcgt tgactagttc agcaagcgta aatacgggct cttttcgcga       60

cccgccaccg                                                              70


<210>  15
<211>  70
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  15
ccagacttcc ttatctttcg gctctcccca gtcgatattc tcgtggaggt tttccggcgt       60

gatgtcgttg                                                              70


<210>  16
<211>  70
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  16
ctcagtccgg aacctccgct accggatccg ccgccagaac cgcctgagct ccagacttcc       60

ttatctttcg                                                              70


<210>  17
<211>  70
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  17
gctccggctg tcagcacagt tgcgacacac atattcacaa gaaagcttct cagtccggaa       60

cctccgctac                                                              70


<210>  18
<211>  78
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  18
gtcgactgca gaattcctat gtgttgctat tgaacaggaa tctgtagcaa agatatgctc       60

cggctgtcag cacagttg                                                     78


<210>  19
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  19
cgtcagatcc gctagcgcta ccggtcgcca ccatggtgag caagggcgag gaggataac        59


<210>  20
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  20
gcttaccatg ctcgagatct gagtccggcc ggacttgtac agctcgtcca tgccg            55


<210>  21
<211>  70
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  21
gcactcatag atccgccagc tacgtcttct gtgtcagcac cgcttccgcc aatcagtacg       60

ttaattttgg                                                              70


<210>  22
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  22
cgggctcttt tcgcgacccg ccaccgccgg tccaagtggc actcatagat ccgccagc         58


<210>  23
<211>  459
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide

<400>  23

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Ser Gly Arg Thr 
225                 230                 235                 240 


Gln Ile Ser Ser Met Val Ser Arg Tyr Val Pro Asp Met Gly Asp Leu 
                245                 250                 255     


Ile Trp Val Asp Phe Asp Pro Thr Lys Gly Ser Glu Gln Ala Gly His 
            260                 265                 270         


Arg Pro Ala Val Val Leu Ser Pro Phe Met Tyr Asn Asn Lys Thr Gly 
        275                 280                 285             


Met Cys Leu Cys Val Pro Cys Thr Thr Gln Ser Lys Gly Tyr Pro Phe 
    290                 295                 300                 


Glu Val Val Leu Ser Gly Gln Glu Arg Asp Gly Val Ala Leu Ala Asp 
305                 310                 315                 320 


Gln Val Lys Ser Ile Ala Trp Arg Ala Arg Gly Ala Thr Lys Lys Gly 
                325                 330                 335     


Thr Val Ala Pro Glu Glu Leu Gln Leu Ile Lys Ala Lys Ile Asn Val 
            340                 345                 350         


Leu Ile Gly Gly Ser Gly Ala Asp Thr Glu Asp Val Ala Gly Gly Ser 
        355                 360                 365             


Met Ser Ala Thr Trp Thr Gly Gly Gly Gly Ser Arg Lys Glu Pro Val 
    370                 375                 380                 


Phe Thr Leu Ala Glu Leu Val Asn Asp Ile Thr Pro Glu Asn Leu His 
385                 390                 395                 400 


Glu Asn Ile Asp Trp Gly Glu Pro Lys Asp Lys Glu Val Trp Ser Ser 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly Gly Ser Gly Leu Arg Ser 
            420                 425                 430         


Phe Leu Val Asn Met Cys Val Ala Thr Val Leu Thr Ala Gly Ala Tyr 
        435                 440                 445             


Leu Cys Tyr Arg Phe Leu Phe Asn Ser Asn Thr 
    450                 455                 


<210>  24
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide

<400>  24

Lys Asp Glu Leu 
1               


<210>  25
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Met Ile Met Leu Gly Ala Ile Cys Ala Ile Ile Val Val Val Ile 
1               5                   10                  15      


Val Ile Tyr Phe Phe 
            20      


<210>  26
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Met Ile Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile 
1               5                   10                  15      


Ile Val Tyr Phe 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  27

Met Ile Val Ile Ile Cys Val Ile Val Leu Ile Ile Val Ile Leu Ile 
1               5                   10                  15      


Ile Leu Phe Ala 
            20  


<210>  28
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  28

Trp Trp Thr Asn Trp Val Ile Pro Ala Ile Ser Ala Val Ala Val Ala 
1               5                   10                  15      


Leu Met Tyr 
            


<210>  29
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  29

Leu Gln Leu Leu Leu Leu Val Cys Leu Val Ala Val Ala Ala Val Ile 
1               5                   10                  15      


Val 
    


<210>  30
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  30

Leu Leu Leu Phe Ala Ala Ala Leu Ala Ala Ala Ala Thr Leu Gly Cys 
1               5                   10                  15      


Thr Gly Leu Val 
            20  


<210>  31
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  31

Leu Leu Arg Trp Val Leu Thr Leu Ser Phe Leu Val Ala Thr Val Ala 
1               5                   10                  15      


Val Gly Leu 
            


