
                                SEQUENCE LISTING

<110> Annunziata, Ida
      D'Azzo, Alessandra
      White-Gilbertson, Shai
      

<120> Methods and Compositions To Detect The
  Level Of Lysosomal Exocytosis Activity And Methods Of Use
  

<130> 44158/423475

<150> 61/529,675          
<151> 2011-08-31

<150> 61/544,855          
<151> 2011-10-07

<160> 4

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1644
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> 1427
<223> n = A,T,C or G

<400> 1
ccaagcttag atcttggagt ctagctgcca gggtcgcggc agctgcgggg agagatgact 60
ggggagcgac ccagcacggc gctcccggac agacgctggg ggccgcggat tctgggcttc 120
tggggaggct gtagggtttg ggtgtttgcc gcgatcttcc tgctgctgtc tctggcagcc 180
tcctggtcca aggctgagaa cgacttcggt ctggtgcagc cgctggtgac catggagcaa 240
ctgctgtggg tgagcgggag acagatcggc tcagtggaca ccttccgcat cccgctcatc 300
acagccactc cgcggggcac tcttctcgcc tttgctgagg cgaggaaaat gtcctcatcc 360
gatgaggggg ccaagttcat cgccctgcgg aggtccatgg accagggcag cacatggtct 420
cctacagcgt tcattgtcaa tgatggggat gtccccgatg ggctgaacct tggggcagta 480
gtgagcgatg ttgagacagg agtagtattt cttttctact ccctttgtgc tcacaaggcc 540
ggctgccagg tggcctctac catgttggta tggagcaagg atgatggtgt ttcctggagc 600
acaccccgga atctctccct ggatattggc actgaagtgt ttgcccctgg accgggctct 660
ggtattcaga aacagcggga gccacggaag ggccgcctca tcgtgtgtgg ccatgggacg 720
ctggagcggg acggagtctt ctgtctcctc agcgatgatc atggtgcctc ctggcgctac 780
ggaagtgggg tcagcggcat cccctacggt cagcccaagc aggaaaatga tttcaatcct 840
gatgaatgcc agccctatga gctcccagat ggctcagtcg tcatcaatgc ccgaaaccag 900
aacaactacc actgccactg ccgaattgtc ctccgcagct atgatgcctg tgatacacta 960
aggccccgtg atgtgacctt cgaccctgag ctcgtggacc ctgtggtagc tgcaggagct 1020
gtagtcacca gctccggcat tgtcttcttc tccaacccag cacatccaga gttccgagtg 1080
aacctgaccc tgcgatggag cttcagcaat ggtacctcat ggcggaaaga gacagtccag 1140
ctatggccag gccccagtgg ctattcatcc ctggcaaccc tggagggcag catggatgga 1200
gaggagcagg ccccccagct ctacgtcctg tatgagaaag gccggaacca ctacacagag 1260
agcatctccg tggccaaaat cagtgtctat gggacactct gagctgtgcc actgccacag 1320
gggtattctg ccttcaggac tctgccttca ggaagacggg tctgtagagg gtctgctgga 1380
gacgcctgaa agacagttcc atcttccttt agactccagc cttggcnaca tcaccttccc 1440
tttaccaggg aaatcacttc ctttaggact gaaagctagg cgtcctctcc cacaacaaag 1500
tcctgccctc atctgagaat actgtctttc catatggcta agtgtggccc caccaccctc 1560
tctgccctcc cgggacattg attggtcctg tcttgggcag gtctagtgag ctgtagaaat 1620
gaatcaatgt gaactcaggg aact                                        1644

<210> 2
<211> 415
<212> PRT
<213> Homo sapiens

<400> 2
Met Thr Gly Glu Arg Pro Ser Thr Ala Leu Pro Asp Arg Arg Trp Gly
 1               5                  10                  15      
Pro Arg Ile Leu Gly Phe Trp Gly Gly Cys Arg Val Trp Val Phe Ala
            20                  25                  30          
Ala Ile Phe Leu Leu Leu Ser Leu Ala Ala Ser Trp Ser Lys Ala Glu
        35                  40                  45              
Asn Asp Phe Gly Leu Val Gln Pro Leu Val Thr Met Glu Gln Leu Leu
    50                  55                  60                  
Trp Val Ser Gly Arg Gln Ile Gly Ser Val Asp Thr Phe Arg Ile Pro
65                  70                  75                  80  
Leu Ile Thr Ala Thr Pro Arg Gly Thr Leu Leu Ala Phe Ala Glu Ala
                85                  90                  95      
Arg Lys Met Ser Ser Ser Asp Glu Gly Ala Lys Phe Ile Ala Leu Arg
            100                 105                 110         
Arg Ser Met Asp Gln Gly Ser Thr Trp Ser Pro Thr Ala Phe Ile Val
        115                 120                 125             
Asn Asp Gly Asp Val Pro Asp Gly Leu Asn Leu Gly Ala Val Val Ser
    130                 135                 140                 
Asp Val Glu Thr Gly Val Val Phe Leu Phe Tyr Ser Leu Cys Ala His
145                 150                 155                 160 
Lys Ala Gly Cys Gln Val Ala Ser Thr Met Leu Val Trp Ser Lys Asp
                165                 170                 175     
Asp Gly Val Ser Trp Ser Thr Pro Arg Asn Leu Ser Leu Asp Ile Gly
            180                 185                 190         
Thr Glu Val Phe Ala Pro Gly Pro Gly Ser Gly Ile Gln Lys Gln Arg
        195                 200                 205             
Glu Pro Arg Lys Gly Arg Leu Ile Val Cys Gly His Gly Thr Leu Glu
    210                 215                 220                 
Arg Asp Gly Val Phe Cys Leu Leu Ser Asp Asp His Gly Ala Ser Trp
225                 230                 235                 240 
Arg Tyr Gly Ser Gly Val Ser Gly Ile Pro Tyr Gly Gln Pro Lys Gln
                245                 250                 255     
Glu Asn Asp Phe Asn Pro Asp Glu Cys Gln Pro Tyr Glu Leu Pro Asp
            260                 265                 270         
Gly Ser Val Val Ile Asn Ala Arg Asn Gln Asn Asn Tyr His Cys His
        275                 280                 285             
Cys Arg Ile Val Leu Arg Ser Tyr Asp Ala Cys Asp Thr Leu Arg Pro
    290                 295                 300                 
Arg Asp Val Thr Phe Asp Pro Glu Leu Val Asp Pro Val Val Ala Ala
305                 310                 315                 320 
Gly Ala Val Val Thr Ser Ser Gly Ile Val Phe Phe Ser Asn Pro Ala
                325                 330                 335     
His Pro Glu Phe Arg Val Asn Leu Thr Leu Arg Trp Ser Phe Ser Asn
            340                 345                 350         
Gly Thr Ser Trp Arg Lys Glu Thr Val Gln Leu Trp Pro Gly Pro Ser
        355                 360                 365             
Gly Tyr Ser Ser Leu Ala Thr Leu Glu Gly Ser Met Asp Gly Glu Glu
    370                 375                 380                 
Gln Ala Pro Gln Leu Tyr Val Leu Tyr Glu Lys Gly Arg Asn His Tyr
385                 390                 395                 400 
Thr Glu Ser Ile Ser Val Ala Lys Ile Ser Val Tyr Gly Thr Leu
                405                 410                 415 


<210> 3
<211> 1815
<212> DNA
<213> Homo sapiens

<400> 3
ggggagatga tccgagccgc gccgccgccg ctgttcctgc tgctgctgct gctgctgctg 60
ctagtgtcct gggcgtcccg aggcgaggca gcccccgacc aggacgagat ccagcgcctc 120
cccgggctgg ccaagcagcc gtctttccgc cagtactccg gctacctcaa aagctccggc 180
tccaagcacc tccactactg gtttgtggag tcccagaagg atcccgagaa cagccctgtg 240
gtgctttggc tcaatggggg tcccggctgc agctcactag atgggctcct cacagagcat 300
ggccccttcc tggtccagcc agatggtgtc accctggagt acaaccccta ttcttggaat 360
ctgattgcca atgtgttata cctggagtcc ccagctgggg tgggcttctc ctactccgat 420
gacaagtttt atgcaactaa tgacactgag gtcgcccaga gcaattttga ggcccttcaa 480
gatttcttcc gcctctttcc ggagtacaag aacaacaaac ttttcctgac cggggagagc 540
tatgctggca tctacatccc caccctggcc gtgctggtca tgcaggatcc cagcatgaac 600
cttcaggggc tggctgtggg caatggactc tcctcctatg agcagaatga caactccctg 660
gtctactttg cctactacca tggccttctg gggaacaggc tttggtcttc tctccagacc 720
cactgctgct ctcaaaacaa gtgtaacttc tatgacaaca aagacctgga atgcgtgacc 780
aatcttcagg aagtggcccg catcgtgggc aactctggcc tcaacatcta caatctctat 840
gccccgtgtg ctggaggggt gcccagccat tttaggtatg agaaggacac tgttgtggtc 900
caggatttgg gcaacatctt cactcgcctg ccactcaagc ggatgtggca tcaggcactg 960
ctgcgctcag gggataaagt gcgcatggac cccccctgca ccaacacaac agctgcttcc 1020
acctacctca acaacccgta cgtgcggaag gccctcaaca tcccggagca gctgccacaa 1080
tgggacatgt gcaactttct ggtaaactta cagtaccgcc gtctctaccg aagcatgaac 1140
tcccagtatc tgaagctgct tagctcacag aaataccaga tcctattata taatggagat 1200
gtagacatgg cctgcaattt catgggggat gagtggtttg tggattccct caaccagaag 1260
atggaggtgc agcgccggcc ctggttagtg aagtacgggg acagcgggga gcagattgcc 1320
ggcttcgtga aggagttctc ccacatcgcc tttctcacga tcaagggcgc cggccacatg 1380
gttcccaccg acaagcccct cgctgccttc accatgttct cccgcttcct gaacaagcag 1440
ccatactgat gaccacagca accagctcca cggcctgatg cagcccctcc cagcctctcc 1500
cgctaggaga gtcctcttct aagcaaagtg cccctgcagg cgggttctgc cgccaggact 1560
gcccccttcc cagagccctg tacatcccag actgggccca gggtctccca tagacagcct 1620
gggggcaagt tagcacttta ttcccgcagc agttcctgaa tggggtggcc tggccccttc 1680
tctgcttaaa gaatgccctt tatgatgcac tgattccatc ccaggaaccc aacagagctc 1740
aggacagccc acagggaggt ggtggacgga ctgtaattga tagattgatt atggaattaa 1800
attgggtaca gcttc                                                  1815

<210> 4
<211> 480
<212> PRT
<213> Homo sapiens

<400> 4
Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro Asp Gln
            20                  25                  30          
Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser Phe Arg
        35                  40                  45              
Gln Tyr Ser Gly Tyr Leu Lys Ser Ser Gly Ser Lys His Leu His Tyr
    50                  55                  60                  
Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val Val Leu
65                  70                  75                  80  
Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu Leu Thr
                85                  90                  95      
Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu Glu Tyr
            100                 105                 110         
Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu Glu Ser
        115                 120                 125             
Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr Ala Thr
    130                 135                 140                 
Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln Asp Phe
145                 150                 155                 160 
Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu Thr Gly
                165                 170                 175     
Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu Val Met
            180                 185                 190         
Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn Gly Leu
        195                 200                 205             
Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala Tyr Tyr
    210                 215                 220                 
His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr His Cys
225                 230                 235                 240 
Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu Glu Cys
                245                 250                 255     
Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser Gly Leu
            260                 265                 270         
Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro Ser His
        275                 280                 285             
Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly Asn Ile
    290                 295                 300                 
Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu Leu Arg
305                 310                 315                 320 
Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr Thr Ala
                325                 330                 335     
Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu Asn Ile
            340                 345                 350         
Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val Asn Leu
        355                 360                 365             
Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu Lys Leu
    370                 375                 380                 
Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp Val Asp
385                 390                 395                 400 
Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser Leu Asn
                405                 410                 415     
Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr Gly Asp
            420                 425                 430         
Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His Ile Ala
        435                 440                 445             
Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp Lys Pro
    450                 455                 460                 
Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln Pro Tyr
465                 470                 475                 480 

