                         SEQUENCE LISTING

<110>  THE TRUSTEES OF DARTMOUTH COLLEGE
       Sentman, Charles
       Zhang, Tong
 
<120>  NKP30 RECEPTOR TARGETED THERAPEUTICS

<130>  76799.000502

<140>  tba
<141>  2012-08-31

<150>  61/529,410
<151>  2011-08-31

<160>  127   

<170>  PatentIn version 3.3

<210>  1
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  2
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala 
            20      


<210>  3
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys Tyr Leu Leu Asp Gly 
1               5                   10                  15      


Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala Leu Phe Leu Arg Val 
            20                  25                  30          


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        35                  40                  45              


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    50                  55                  60                  


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
65                  70                  75                  80  


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                85                  90                  95      


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            100                 105                 110         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        115                 120                 125             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    130                 135                 140             


<210>  4
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  5
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  6
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln 
1               5                   10                  15  


<210>  8
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  8

Leu Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu 
1               5                   10                  15      


Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr 
            20                  25                  30          


Ala Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        35                  40                  45              


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    50                  55                  60                  


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
65                  70                  75                  80  


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                85                  90                  95      


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            100                 105                 110         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        115                 120                 125             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    130                 135                 140                 


Leu Pro 
145     


<210>  9
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  10
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  10

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  11
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala 
    130                 135                 140                 


Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg Gln Leu 
                165                 170                 175     


Pro Ala Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser Ser Ala 
            180                 185                 190         


His Leu Leu Pro Pro Val Pro Gly Gly 
        195                 200     


<210>  12
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Gly Thr Val Leu Leu Leu Arg Ala Gly Phe Tyr Ala Val Ser Phe 
1               5                   10                  15      


Leu Ser Val Ala Val 
            20      


<210>  13
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Ser Thr Val Tyr Tyr Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro 
1               5                   10                  15      


Arg Arg Gln Leu Pro Ala Val Val Pro Ala Pro Leu Pro Pro Pro Cys 
            20                  25                  30          


Gly Ser Ser Ala His Leu Leu Pro Pro Val Pro Gly Gly 
        35                  40                  45  


<210>  14
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala 
        


<210>  15
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  15

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         


His Pro Gln Leu Gly 
        115         


<210>  16
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala 
    130                 135                 140                 


Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Lys Tyr Ala Lys Ser Thr Leu Ser Gly Phe Pro Gln 
                165                 170                 175     


Leu 
    


<210>  17
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Gly Thr Val Leu Leu Leu Arg Ala Gly Phe Tyr Ala Val Ser Phe 
1               5                   10                  15      


Leu Ser Val Ala Val 
            20      


<210>  18
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala 
        


<210>  19
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  19

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         


His Pro Gln Leu Gly 
        115         


<210>  20
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Ser Thr Val Tyr Tyr Gln Gly Lys Tyr Ala Lys Ser Thr Leu Ser 
1               5                   10                  15      


Gly Phe Pro Gln Leu 
            20      


<210>  21
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala 
    130                 135                 140                 


Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Lys Cys His Cys His Met Gly Thr His Cys His Ser 
                165                 170                 175     


Ser Asp Gly Pro Arg Gly Val Ile Pro Glu Pro Arg Cys Pro 
            180                 185                 190 


<210>  22
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Gly Thr Val Leu Leu Leu Arg Ala Gly Phe Tyr Ala Val Ser Phe 
1               5                   10                  15      


Leu Ser Val Ala Val 
            20      


<210>  23
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala 
        


<210>  24
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  24

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         


His Pro Gln Leu Gly 
        115         


<210>  25
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Ser Thr Val Tyr Tyr Gln Gly Lys Cys His Cys His Met Gly Thr 
1               5                   10                  15      


His Cys His Ser Ser Asp Gly Pro Arg Gly Val Ile Pro Glu Pro Arg 
            20                  25                  30          


Cys Pro 
        


<210>  26
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Trp Lys His Leu Cys Pro Ser Pro Leu 
        35                  40                  45              


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
    50                  55                  60                  


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
65                  70                  75                  80  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                85                  90                  95      


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            100                 105                 110         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        115                 120             


<210>  27
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
            20                  25                  30          


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
        35                  40                  45              


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
    50                  55                  60                  


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
65                  70                  75                  80  


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
                85                  90                  95      


Ala Ala Tyr Arg Ser 
            100     


<210>  28
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  28

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
            20                  25                  30  


<210>  29
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  29

Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
1               5                   10                  15      


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
            20                  25                  30          


Phe Ala Ala Tyr Arg Ser 
        35              


<210>  30
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  30

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


<210>  31
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Tyr Asn Glu Lys Ser Asn Gly Thr Ile 
        35                  40                  45              


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
    50                  55                  60                  


Pro Ser Lys Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
65                  70                  75                  80  


<210>  32
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  33
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  34
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  34

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        115                 120                 125             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    130                 135                 140                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
145                 150                 155                 160 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                165                 170                 175     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg 
            180                 185                 190         


Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser 
        195                 200                 205             


Leu Ser Ala Arg Tyr Val 
    210                 


<210>  35
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  35

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  36
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Gly Asn Arg Arg Arg 
                165                 170                 175     


Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser 
            180                 185                 190         


Leu Ser Ala Arg Tyr Val 
        195             


<210>  37
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
    50                  55                  60                  


Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
65                  70                  75                  80  


Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
                85                  90              


<210>  38
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln 
            


<210>  39
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  39

Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr 
1               5                   10                  15      


Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Leu Leu Ala 
            20                  25                  30          


Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile Val Gly Ala 
        35                  40                  45              


Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly 
    50                  55                  60                  


Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
65                  70                  


<210>  40
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  40

Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
1               5                   10                  15      


Val Gly Ala Val Phe 
            20      


<210>  41
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  41

Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210>  42
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
    50                  55                  60                  


Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
65                  70                  75                  80  


Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
                85                  90          


<210>  43
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln 
            


<210>  44
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  44

Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr 
1               5                   10                  15      


Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Leu Leu Ala 
            20                  25                  30          


Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile Val Gly Ala 
        35                  40                  45              


Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Asp Gly Lys 
    50                  55                  60                  


Val Tyr Ile Asn Met Pro Gly Arg Gly 
65                  70              


<210>  45
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  45

Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
1               5                   10                  15      


Val Gly Ala Val Phe 
            20      


<210>  46
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  47
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  47

Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu 
1               5                   10                  15      


Ile Ala Leu Ala Val 
            20      


<210>  48
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Thr Arg Lys 
65                  70                  75                  80  


Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln 
                85                  90                  95      


Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
            100                 105                 110         


<210>  49
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  49

Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu 
1               5                   10                  15      


Ile Ala Leu Ala Val 
            20      


<210>  50
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr 
65                  70                  75                  80  


Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr 
                85                  90                  95      


Gln Arg Pro Tyr Tyr Lys 
            100         


<210>  51
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln 
65                  70                  75                  80  


Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln 
                85                  90                  95      


Arg Pro Tyr Tyr Lys 
            100     


<210>  52
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  53
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  53

Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly 
1               5                   10                  15      


Ala Leu Phe Leu His 
            20      


<210>  54
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  54

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  55
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  56
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  56

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  57
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  58
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  58

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu 
            20      


<210>  59
<211>  201
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  59

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala 
    130                 135                 140                 


Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg Gln Leu 
                165                 170                 175     


Pro Ala Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser Ser Ala 
            180                 185                 190         


His Leu Leu Pro Pro Val Pro Gly Gly 
        195                 200     


<210>  60
<211>  271
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  60

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Ser Leu Cys Tyr Leu Leu Asp Gly 
    130                 135                 140                 


Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala Leu Phe Leu Arg Val 
145                 150                 155                 160 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
                165                 170                 175     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            180                 185                 190         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln 
        195                 200                 205             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    210                 215                 220                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
225                 230                 235                 240 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                245                 250                 255     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            260                 265                 270     


<210>  61
<211>  320
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  61

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Ser Phe Trp Val Leu Val Val Val 
    130                 135                 140                 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
145                 150                 155                 160 


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
                165                 170                 175     


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
            180                 185                 190         


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Leu Arg 
        195                 200                 205             


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
    210                 215                 220                 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
225                 230                 235                 240 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
                245                 250                 255     


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
            260                 265                 270         


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
        275                 280                 285             


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
    290                 295                 300                 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
305                 310                 315                 320 


<210>  62
<211>  282
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  62

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Ser Phe Trp Val Leu Val Val Val 
    130                 135                 140                 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
145                 150                 155                 160 


Ile Phe Trp Val Arg Ser Lys Lys Leu Arg Val Lys Phe Ser Arg Ser 
                165                 170                 175     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            180                 185                 190         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        195                 200                 205             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
    210                 215                 220                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
225                 230                 235                 240 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                245                 250                 255     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            260                 265                 270         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        275                 280         


<210>  63
<211>  273
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  63

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Ser Ile Tyr Ile Trp Ala Pro Leu 
    130                 135                 140                 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Lys Leu 
145                 150                 155                 160 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                165                 170                 175     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            180                 185                 190         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        195                 200                 205             


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    210                 215                 220                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
225                 230                 235                 240 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                245                 250                 255     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            260                 265                 270         


Arg 
    


<210>  64
<211>  924
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  64
atggcctgga tgctgttgct catcttgatc atggtccatc caggatcctg tgctctctgg     60

gtgtcccagc cccctgagat tcgtaccctg gaaggatcct ctgccttcct gccctgctcc    120

ttcaatgcca gccaagggag actggccatt ggctccgtca cgtggttccg agatgaggtg    180

gttccaggga aggaggtgag gaatggaacc ccagagttca ggggccgcct ggccccactt    240

gcttcttccc gtttcctcca tgaccaccag gctgagctgc acatccggga cgtgcgaggc    300

catgacgcca gcatctacgt gtgcagagtg gaggtgctgg gccttggtgt cgggacaggg    360

aatgggactc ggctggtggt ggagaaagaa catcctcagc taggggctag cttttgggtg    420

ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt    480

attttctggg tgaggagtaa gaggagcctg tgcgcacgcc cacgccgcag ccccgcccaa    540

gaagatggca aagtctacat caacatgcca ggcaggggca agcttagagt gaagttcagc    600

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat    660

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg    720

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat    780

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg    840

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac    900

atgcaggccc tgccccctcg ctaa                                           924


<210>  65
<211>  307
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  65

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Ser Phe Trp Val Leu Val Val Val 
    130                 135                 140                 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
145                 150                 155                 160 


Ile Phe Trp Val Arg Ser Lys Arg Ser Leu Cys Ala Arg Pro Arg Arg 
                165                 170                 175     


Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg 
            180                 185                 190         


Gly Lys Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        195                 200                 205             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    210                 215                 220                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
225                 230                 235                 240 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                245                 250                 255     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            260                 265                 270         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        275                 280                 285             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    290                 295                 300                 


Pro Pro Arg 
305         


<210>  66
<211>  924
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  66
atggcctgga tgctgttgct catcttgatc atggtccatc caggatcctg tgctctctgg     60

gtgtcccagc cccctgagat tcgtaccctg gaaggatcct ctgccttcct gccctgctcc    120

ttcaatgcca gccaagggag actggccatt ggctccgtca cgtggttccg agatgaggtg    180

gttccaggga aggaggtgag gaatggaacc ccagagttca ggggccgcct ggccccactt    240

gcttcttccc gtttcctcca tgaccaccag gctgagctgc acatccggga cgtgcgaggc    300

catgacgcca gcatctacgt gtgcagagtg gaggtgctgg gccttggtgt cgggacaggg    360

aatgggactc ggctggtggt ggagaaagaa catcctcagc taggggctag cttttgggtg    420

ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt    480

attttctggg tgaggagtaa gaggagcaag cttagagtga agttcagcag gagcgcagac    540

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga    600

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg    660

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag    720

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt    780

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg    840

ccccctcgcc tgtgcgcacg cccacgccgc agccccgccc aagaagatgg caaagtctac    900

atcaacatgc caggcagggg ctga                                           924


<210>  67
<211>  307
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  67

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Ser Phe Trp Val Leu Val Val Val 
    130                 135                 140                 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
145                 150                 155                 160 


Ile Phe Trp Val Arg Ser Lys Arg Ser Lys Leu Arg Val Lys Phe Ser 
                165                 170                 175     


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
            180                 185                 190         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        195                 200                 205             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    210                 215                 220                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
225                 230                 235                 240 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                245                 250                 255     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            260                 265                 270         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Cys Ala Arg Pro 
        275                 280                 285             


Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro 
    290                 295                 300                 


Gly Arg Gly 
305         


<210>  68
<211>  1002
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  68
atggcctgga tgctgttgct catcttgatc atggtccatc caggatcctg tgctctctgg     60

gtgtcccagc cccctgagat tcgtaccctg gaaggatcct ctgccttcct gccctgctcc    120

ttcaatgcca gccaagggag actggccatt ggctccgtca cgtggttccg agatgaggtg    180

gttccaggga aggaggtgag gaatggaacc ccagagttca ggggccgcct ggccccactt    240

gcttcttccc gtttcctcca tgaccaccag gctgagctgc acatccggga cgtgcgaggc    300

catgacgcca gcatctacgt gtgcagagtg gaggtgctgg gccttggtgt cgggacaggg    360

aatgggactc ggctggtggt ggagaaagaa catcctcagc taggggctag cttttgggtg    420

ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt    480

attttctggg tgaggagtaa gaggagcctc gagcaacgaa ggaaatatag atcaaacaaa    540

ggagaaagtc ctgtggagcc tgcagagcct tgtcgttaca gctgccccag ggaggaggag    600

ggcagcacca tccccatcca ggaggattac cgaaaaccgg agcctgcctg ctcccccaag    660

cttagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag    720

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt    780

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac    840

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag    900

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac    960

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                      1002


<210>  69
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  69

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Ser Phe Trp Val Leu Val Val Val 
    130                 135                 140                 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
145                 150                 155                 160 


Ile Phe Trp Val Arg Ser Lys Arg Ser Leu Glu Gln Arg Arg Lys Tyr 
                165                 170                 175     


Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro Cys Arg 
            180                 185                 190         


Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu 
        195                 200                 205             


Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro Lys Leu Arg Val Lys 
    210                 215                 220                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
225                 230                 235                 240 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                245                 250                 255     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            260                 265                 270         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        275                 280                 285             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    290                 295                 300                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
305                 310                 315                 320 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                325                 330             


<210>  70
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  70
agtgcgagga gattcggcag cttat                                           25


<210>  71
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  71
gcgaggagat tcggcagctt atttc                                           25


<210>  72
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  72
ccaccatcct ctatgagatc ttgct                                           25


<210>  73
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  73
tcctctatga gatcttgcta gggaa                                           25


<210>  74
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  74
tctatggctt caactggcta gggtg                                           25


<210>  75
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  75
caggtagagg ccttgtccac ctaat                                           25


<210>  76
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  76
gcagcagaca ctgcttctta cttct                                           25


<210>  77
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  77
gacactgctt cttacttctg tgcta                                           25


<210>  78
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  78
cctctgcctc ttatcagttg gcgtt                                           25


<210>  79
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  79
gagcaaagtg gttattatgt ctgct                                           25


<210>  80
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  80
aagcaaacca gaagatgcga acttt                                           25


<210>  81
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  81
gacctgtatt ctggcctgaa tcaga                                           25


<210>  82
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  82
ggcctctgcc tcttatcagt t                                               21


<210>  83
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  83
gcctctgcct cttatcagtt g                                               21


<210>  84
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  84
gcctcttatc agttggcgtt t                                               21


<210>  85
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  85
aggatcacct gtcactgaag g                                               21


<210>  86
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  86
ggatcacctg tcactgaagg a                                               21


<210>  87
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  87
gaattggagc aaagtggtta t                                               21


<210>  88
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  88
ggagcaaagt ggttattatg t                                               21


<210>  89
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  89
gcaaaccaga agatgcgaac t                                               21


<210>  90
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  90
acctgtattc tggcctgaat c                                               21


<210>  91
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  91
gcctgaatca gagacgcatc t                                               21


<210>  92
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  92
ctgaaatact atggcaacac aatgataaa                                       29


<210>  93
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  93
aaacataggc agtgatgagg atcacctgt                                       29


<210>  94
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  94
attgtcatag tggacatctg catcactgg                                       29


<210>  95
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  95
ctgtattctg gcctgaatca gagacgcat                                       29


<210>  96
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  96
gatacctata gaggaacttg a                                               21


<210>  97
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  97
gacagagtgt ttgtgaattg c                                               21


<210>  98
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  98
gaacactgct ctcagacatt a                                               21


<210>  99
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  99
ggacccacga ggaatatata g                                               21


<210>  100
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  100
ggtgtaatgg gacagatata t                                               21


<210>  101
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  101
gcaagttcat tatcgaatgt g                                               21


<210>  102
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  102
ggctggcatc attgtcactg a                                               21


<210>  103
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  103
gctggcatca ttgtcactga t                                               21


<210>  104
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  104
gcatcattgt cactgatgtc a                                               21


<210>  105
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  105
gctttgggag tcttctgctt t                                               21


<210>  106
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  106
tggaacatag cacgtttctc tctggcctg                                       29


<210>  107
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  107
ctgctctcag acattacaag actggacct                                       29


<210>  108
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  108
accgtggctg gcatcattgt cactgatgt                                       29


<210>  109
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  109
tgatgctcag tacagccacc ttggaggaa                                       29


<210>  110
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  110
ggctatcatt cttcttcaag g                                               21


<210>  111
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  111
gcccagtcaa tcaaaggaaa c                                               21


<210>  112
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  112
ggttaaggtg tatgactatc a                                               21


<210>  113
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  113
ggttcggtac ttctgacttg t                                               21


<210>  114
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  114
gaatgtgtca gaactgcatt g                                               21


<210>  115
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  115
gcagccacca tatctggctt t                                               21


<210>  116
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  116
ggctttctct ttgctgaaat c                                               21


<210>  117
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  117
gctttctctt tgctgaaatc g                                               21


<210>  118
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  118
gccaccttca aggaaaccag t                                               21


<210>  119
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  119
gaaaccagtt gaggaggaat t                                               21


<210>  120
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  120
ggctttctct ttgctgaaat cgtcagcat                                       29


<210>  121
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  121
aggatggagt tcgccagtcg agagcttca                                       29


<210>  122
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  122
cctcaaggat cgagaagatg accagtaca                                       29


<210>  123
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  123
tacagccacc ttcaaggaaa ccagttgag                                       29


<210>  124
<211>  816
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  124
atggcctgga tgctgttgct catcttgatc atggtccatc caggatcctg tgctctctgg     60

gtgtcccagc cccctgagat tcgtaccctg gaaggatcct ctgccttcct gccctgctcc    120

ttcaatgcca gccaagggag actggccatt ggctccgtca cgtggttccg agatgaggtg    180

gttccaggga aggaggtgag gaatggaacc ccagagttca ggggccgcct ggccccactt    240

gcttcttccc gtttcctcca tgaccaccag gctgagctgc acatccggga cgtgcgaggc    300

catgacgcca gcatctacgt gtgcagagtg gaggtgctgg gccttggtgt cgggacaggg    360

aatgggactc ggctggtggt ggagaaagaa catcctcagc taggggctag cctctgctac    420

ctgctggatg gaatcctctt catctatggt gtcattctca ctgccttgtt cctgagagtg    480

aagttcagca ggagcgcaga cgcccccgcg taccagcagg gccagaacca gctctataac    540

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac    600

cctgagatgg ggggaaagcc gcagagaagg aagaaccctc aggaaggcct gtacaatgaa    660

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg    720

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac    780

gacgcccttc acatgcaggc cctgccccct cgctaa                              816


<210>  125
<211>  963
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  125
atggcctgga tgctgttgct catcttgatc atggtccatc caggatcctg tgctctctgg     60

gtgtcccagc cccctgagat tcgtaccctg gaaggatcct ctgccttcct gccctgctcc    120

ttcaatgcca gccaagggag actggccatt ggctccgtca cgtggttccg agatgaggtg    180

gttccaggga aggaggtgag gaatggaacc ccagagttca ggggccgcct ggccccactt    240

gcttcttccc gtttcctcca tgaccaccag gctgagctgc acatccggga cgtgcgaggc    300

catgacgcca gcatctacgt gtgcagagtg gaggtgctgg gccttggtgt cgggacaggg    360

aatgggactc ggctggtggt ggagaaagaa catcctcagc taggggctag cttttgggtg    420

ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt    480

attttctggg tgaggagtaa gaggagcagg ctcctgcaca gtgactacat gaacatgact    540

ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc    600

gcagcctatc gctccaagct tagagtgaag ttcagcagga gcgcagacgc ccccgcgtac    660

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat    720

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgca gagaaggaag    780

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt    840

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt    900

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc    960

taa                                                                  963


<210>  126
<211>  849
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  126
atggcctgga tgctgttgct catcttgatc atggtccatc caggatcctg tgctctctgg     60

gtgtcccagc cccctgagat tcgtaccctg gaaggatcct ctgccttcct gccctgctcc    120

ttcaatgcca gccaagggag actggccatt ggctccgtca cgtggttccg agatgaggtg    180

gttccaggga aggaggtgag gaatggaacc ccagagttca ggggccgcct ggccccactt    240

gcttcttccc gtttcctcca tgaccaccag gctgagctgc acatccggga cgtgcgaggc    300

catgacgcca gcatctacgt gtgcagagtg gaggtgctgg gccttggtgt cgggacaggg    360

aatgggactc ggctggtggt ggagaaagaa catcctcagc taggggctag cttttgggtg    420

ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt    480

attttctggg tgaggagtaa gaagcttaga gtgaagttca gcaggagcgc agacgccccc    540

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag    600

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgcagaga    660

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc    720

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac    780

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc    840

cctcgctaa                                                            849


<210>  127
<211>  819
<212>  DNA
<213>  Artificial

<220>
<223>  Chimeric receptor

<400>  127
atggcctgga tgctgttgct catcttgatc atggtccatc caggatcctg tgctctctgg     60

gtgtcccagc cccctgagat tcgtaccctg gaaggatcct ctgccttcct gccctgctcc    120

ttcaatgcca gccaagggag actggccatt ggctccgtca cgtggttccg agatgaggtg    180

gttccaggga aggaggtgag gaatggaacc ccagagttca ggggccgcct ggccccactt    240

gcttcttccc gtttcctcca tgaccaccag gctgagctgc acatccggga cgtgcgaggc    300

catgacgcca gcatctacgt gtgcagagtg gaggtgctgg gccttggtgt cgggacaggg    360

aatgggactc ggctggtggt ggagaaagaa catcctcagc taggggctag catctacatc    420

tgggcgccct tggccgggac ttgtggggtc cttctcctgt cactggttat caccaagctt    480

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc    540

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc    600

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat    660

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc    720

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc    780

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                           819


