                         SEQUENCE LISTING

<110>  QUIDEL CORPORATION
       Li, Yunsheng
       Olivo, Paul D.
       Kim, Jaekyung
 
<120>  Compositions And Methods For Detecting Autoantibodies

<130>  DHI-17182

<140>  PCT/US11/50976
<141>  2011-09-09

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Asp Leu Pro 
1               5                   10                  15      


Arg Asp Leu Gly Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
    50                  55                  60                  


Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Thr Leu Pro Ser Lys Glu Lys Phe Thr Ser Leu 
            260                 265                 270         


Leu Val Ala Thr Leu Thr Tyr Pro Ser His Cys Cys Ala Phe Ser Asn 
        275                 280                 285             


Leu Pro Lys Lys Glu Gln Asn Phe Ser Phe Ser Ile Phe Glu Asn Phe 
    290                 295                 300                 


Ser Lys Gln Cys Glu Ser Thr Val Arg Lys Ala Asp Asn Glu Thr Leu 
305                 310                 315                 320 


Tyr Ser Ala Ile Phe Glu Glu Asn Glu Leu Ser Gly Trp Asp Glu Leu 
                325                 330                 335     


Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His Tyr Asp 
            340                 345                 350         


Tyr Thr Ile Cys Gly Asp Ser Glu Asp Met Val Cys Thr Pro Lys Ser 
        355                 360                 365             


Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe Leu Arg 
    370                 375                 380                 


Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn Val Phe 
385                 390                 395                 400 


Val Leu Leu Ile Leu Leu Thr Ser His Tyr Lys Leu Asn Val Pro Arg 
                405                 410                 415     


Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly Met Tyr 
            420                 425                 430         


Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu Tyr Tyr 
        435                 440                 445             


Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr Ala Gly 
    450                 455                 460                 


Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu Thr Val 
465                 470                 475                 480 


Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg Leu Asp 
                485                 490                 495     


Arg Lys Ile Arg Leu Arg His Ala Cys Ala Ile Met Val Gly Gly Trp 
            500                 505                 510         


Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile Ser Ser 
        515                 520                 525             


Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr Pro Leu 
    530                 535                 540                 


Ala Leu Ala Tyr Ile Val Phe Val Leu Thr Leu Asn Ile Val Ala Phe 
545                 550                 555                 560 


Val Ile Val Cys Cys Cys Tyr Val Lys Ile Tyr Ile Thr Val Arg Asn 
                565                 570                 575     


Pro Gln Tyr Asn Pro Gly Asp Lys Asp Thr Lys Ile Ala Lys Arg Met 
            580                 585                 590         


Ala Val Leu Ile Phe Thr Asp Phe Ile Cys Met Ala Pro Ile Ser Phe 
        595                 600                 605             


Tyr Ala Leu Ser Ala Ile Leu Asn Lys Pro Leu Ile Thr Val Ser Asn 
    610                 615                 620                 


Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys Ala Asn 
625                 630                 635                 640 


Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp Val Phe 
                645                 650                 655     


Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln Ala Tyr 
            660                 665                 670         


Arg Gly Gln Arg Val Pro Pro Lys Asn Ser Thr Asp Ile Gln Val Gln 
        675                 680                 685             


Lys Val Thr His Asp Met Arg Gln Gly Leu His Asn Met Glu Asp Val 
    690                 695                 700                 


Tyr Glu Leu Ile Glu Asn Ser His Leu Thr Pro Lys Lys Gln Gly Gln 
705                 710                 715                 720 


Ile Ser Glu Glu Tyr Met Gln Thr Val Leu 
                725                 730 


<210>  2
<211>  2193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
atgaggccgg cggacttgct gcagctggtg ctgctgctcg acctgcccag ggacctgggc       60

ggaatggggt gttcgtctcc accctgcgag tgccatcagg aggaggactt cagagtcacc      120

tgcaaggata ttcaacgcat ccccagctta ccgcccagta cgcagactct gaagcttatt      180

gagactcacc tgagaactat tccaagtcat gcattttcta atctgcccaa tatttccaga      240

atctacgtat ctatagatgt gactctgcag cagctggaat cacactcctt ctacaatttg      300

agtaaagtga ctcacataga aattcggaat accaggaact taacttacat agaccctgat      360

gccctcaaag agctccccct cctaaagttc cttggcattt tcaacactgg acttaaaatg      420

ttccctgacc tgaccaaagt ttattccact gatatattct ttatacttga aattacagac      480

aacccttaca tgacgtcaat ccctgtgaat gcttttcagg gactatgcaa tgaaaccttg      540

acactgaagc tgtacaacaa tggctttact tcagtccaag gatatgcttt caatgggaca      600

aagctggatg ctgtttacct aaacaagaat aaatacctga cagttattga caaagatgca      660

tttggaggag tatacagtgg accaagcttg ctggacgtgt ctcaaaccag tgtcactgcc      720

cttccatcca aaggcctgga gcacctgaag gaactgatag caagaaacac ctggactctt      780

aagacactgc cctccaaaga aaaattcacg agcctcctgg tcgccacgct gacctacccc      840

agccactgct gcgccttcag taatttgccg aagaaagaac agaatttttc attttccatt      900

tttgaaaact tctccaaaca atgcgaaagc acagttagaa aagcagataa cgagacgctt      960

tattccgcca tctttgagga gaatgaactc agtggctggg atgagctcaa aaacccccag     1020

gaagagactc tacaagcttt tgacagccat tatgactaca ccatatgtgg ggacagtgaa     1080

gacatggtgt gtacccccaa gtccgatgag ttcaacccgt gtgaagacat aatgggctac     1140

aagttcctga gaattgtggt gtggttcgtt agtctgctgg ctctcctggg caatgtcttt     1200

gtcctgctta ttctcctcac cagccactac aaactgaacg tcccccgctt tctcatgtgc     1260

aacctggcct ttgcggattt ctgcatgggg atgtacctgc tcctcatcgc ctctgtagac     1320

ctctacactc actctgagta ctacaaccat gccatcgact ggcagacagg ccctgggtgc     1380

aacacggctg gtttcttcac tgtctttgca agcgagttat cggtgtatac gctgacggtc     1440

atcaccctgg agcgctggta tgccatcacc ttcgccatgc gcctggaccg gaagatccgc     1500

ctcaggcacg catgtgccat catggttggg ggctgggttt gctgcttcct tctcgccctg     1560

cttcctttgg tgggaataag tagctatgcc aaagtcagta tctgcctgcc catggacacc     1620

gagacccctc ttgctctggc atatattgtt tttgttctga cgctcaacat agttgccttc     1680

gtcatcgtct gctgctgtta tgtgaagatc tacatcacag tccgaaatcc gcagtacaac     1740

ccaggggaca aagataccaa aattgccaag aggatggctg tgttgatctt caccgacttc     1800

atatgcatgg ccccaatctc attctatgct ctgtcagcaa ttctgaacaa gcctctcatc     1860

actgttagca actccaaaat cttgctggta ctcttctatc cacttaactc ctgtgccaat     1920

ccattcctct atgctatttt caccaaggcc ttccagaggg atgtgttcat cctactcagc     1980

aagtttggca tctgtaaacg ccaggctcag gcataccggg ggcagagggt tcctccaaag     2040

aacagcactg atattcaggt tcaaaaggtt acccacgaca tgaggcaggg tctccacaac     2100

atggaagatg tctatgaact gattgaaaac tcccatctaa ccccaaagaa gcaaggccaa     2160

atctcagaag agtatatgca aacggttttg taa                                  2193


<210>  3
<211>  550
<212>  PRT
<213>  Renilla reniformis

<400>  3

Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asn Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Asn Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ser Lys Leu 
545                 550 


<210>  4
<211>  1653
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
atggaagacg ccaaaaacat aaagaaaggc ccggcgccat tctatcctct agaggatgga       60

accgctggag agcaactgca taaggctatg aagagatacg ccctggttcc tggaacaatt      120

gcttttacag atgcacatat cgaggtgaac atcacgtacg cggaatactt cgaaatgtcc      180

gttcggttgg cagaagctat gaaacgatat gggctgaata caaatcacag aatcgtcgta      240

tgcagtgaaa actctcttca attctttatg ccggtgttgg gcgcgttatt tatcggagtt      300

gcagttgcgc ccgcgaacga catttataat gaacgtgaat tgctcaacag tatgaacatt      360

tcgcagccta ccgtagtgtt tgtttccaaa aaggggttgc aaaaaatttt gaacgtgcaa      420

aaaaaattac caataatcca gaaaattatt atcatggatt ctaaaacgga ttaccaggga      480

tttcagtcga tgtacacgtt cgtcacatct catctacctc ccggttttaa tgaatacgat      540

tttgtaccag agtcctttga tcgtgacaaa acaattgcac tgataatgaa ttcctctgga      600

tctactgggt tacctaaggg tgtggccctt ccgcatagaa ctgcctgcgt cagattctcg      660

catgccagag atcctatttt tggcaatcaa atcattccgg atactgcgat tttaagtgtt      720

gttccattcc atcacggttt tggaatgttt actacactcg gatatttgat atgtggattt      780

cgagtcgtct taatgtatag atttgaagaa gagctgtttt tacgatccct tcaggattac      840

aaaattcaaa gtgcgttgct agtaccaacc ctattttcat tcttcgccaa aagcactctg      900

attgacaaat acgatttatc taatttacac gaaattgctt ctgggggcgc acctctttcg      960

aaagaagtcg gggaagcggt tgcaaaacgc ttccatcttc cagggatacg acaaggatat     1020

gggctcactg agactacatc agctattctg attacacccg agggggatga taaaccgggc     1080

gcggtcggta aagttgttcc attttttgaa gcgaaggttg tggatctgga taccgggaaa     1140

acgctgggcg ttaatcagag aggcgaatta tgtgtcagag gacctatgat tatgtccggt     1200

tatgtaaaca atccggaagc gaccaacgcc ttgattgaca aggatggatg gctacattct     1260

ggagacatag cttactggga cgaagacgaa cacttcttca tagttgaccg cttgaagtct     1320

ttaattaaat acaaaggata tcaggtggcc cccgctgaat tggaatcgat attgttacaa     1380

caccccaaca tcttcgacgc gggcgtggca ggtcttcccg acgatgacgc cggtgaactt     1440

cccgccgccg ttgttgtttt ggagcacgga aagacgatga cggaaaaaga gatcgtggat     1500

tacgtcgcca gtcaagtaac aaccgcgaaa aagttgcgcg gaggagttgt gtttgtggac     1560

gaagtaccga aaggtcttac cggaaaactc gacgcaagaa aaatcagaga gatcctcata     1620

aaggccaaga agggcggaaa gtccaaattg taa                                  1653


