                         SEQUENCE LISTING

<110>  Beth Israel Deaconess Medical Center, Inc.
 
<120>  MODIFIED ADENOVIRAL VECTORS AND METHODS OF TREATMENT USING SAME

<130>  01948-203WO2

<150>  61/533,029
<151>  2011-09-09

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Adenovirus serotype 5


<220>
<221>  DOMAIN
<222>  (1)..(29)
<223>  HVR1

<400>  1

Glu Ala Ala Thr Ala Leu Glu Ile Asn Leu Glu Glu Glu Asp Asp Asp 
1               5                   10                  15      


Asn Glu Asp Glu Val Asp Glu Gln Ala Glu Gln Gln Lys 
            20                  25                  


<210>  2
<211>  6
<212>  PRT
<213>  Adenovirus serotype 5


<220>
<221>  DOMAIN
<222>  (1)..(6)
<223>  HVR2

<400>  2

Val Glu Gly Gln Thr Pro 
1               5       


<210>  3
<211>  3
<212>  PRT
<213>  Adenovirus serotype 5


<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  HVR3

<400>  3

Glu Thr Glu 
1           


<210>  4
<211>  7
<212>  PRT
<213>  Adenovirus serotype 5


<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  HVR4

<400>  4

Lys Gln Gln Asn Gly Lys Leu 
1               5           


<210>  5
<211>  13
<212>  PRT
<213>  Adenovirus serotype 5


<220>
<221>  DOMAIN
<222>  (1)..(13)
<223>  HVR5

<400>  5

Thr Thr Glu Ala Thr Ala Gly Asn Gly Asp Asn Leu Thr 
1               5                   10              


<210>  6
<211>  3
<212>  PRT
<213>  Adenovirus serotype 5


<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  HVR6

<400>  6

Ile Lys Glu 
1           


<210>  7
<211>  14
<212>  PRT
<213>  Adenovirus serotype 5


<220>
<221>  DOMAIN
<222>  (1)..(14)
<223>  HVR7

<400>  7

Lys Thr Gly Gln Glu Asn Gly Trp Glu Lys Asp Ala Thr Glu 
1               5                   10                  


<210>  8
<211>  182
<212>  PRT
<213>  Adenovirus serotype 5


<220>
<221>  DOMAIN
<222>  (1)..(182)
<223>  Fiber knob domain

<400>  8

Thr Leu Trp Thr Thr Pro Ala Pro Ser Pro Asn Cys Arg Leu Asn Ala 
1               5                   10                  15      


Glu Lys Asp Ala Lys Leu Thr Leu Val Leu Thr Lys Cys Gly Ser Gln 
            20                  25                  30          


Ile Leu Ala Thr Val Ser Val Leu Ala Val Lys Gly Ser Leu Ala Pro 
        35                  40                  45              


Ile Ser Gly Thr Val Gln Ser Ala His Leu Ile Ile Arg Phe Asp Glu 
    50                  55                  60                  


Asn Gly Val Leu Leu Asn Asn Ser Phe Leu Asp Pro Glu Tyr Trp Asn 
65                  70                  75                  80  


Phe Arg Asn Gly Asp Leu Thr Glu Gly Thr Ala Tyr Thr Asn Ala Val 
                85                  90                  95      


Gly Phe Met Pro Asn Leu Ser Ala Tyr Pro Lys Ser His Gly Lys Thr 
            100                 105                 110         


Ala Lys Ser Asn Ile Val Ser Gln Val Tyr Leu Asn Gly Asp Lys Thr 
        115                 120                 125             


Lys Pro Val Thr Leu Thr Ile Thr Leu Asn Gly Thr Gln Glu Thr Gly 
    130                 135                 140                 


Asp Thr Thr Pro Ser Ala Tyr Ser Met Ser Phe Ser Trp Asp Trp Ser 
145                 150                 155                 160 


Gly His Asn Tyr Ile Asn Glu Ile Phe Ala Thr Ser Ser Tyr Thr Phe 
                165                 170                 175     


Ser Tyr Ile Ala Gln Glu 
            180         


<210>  9
<211>  21
<212>  PRT
<213>  Adenovirus serotype 11


<220>
<221>  DOMAIN
<222>  (1)..(21)
<223>  HVR1

<400>  9

Ala Glu Gly Val Lys Asn Thr Thr Gly Glu Glu His Val Thr Glu Glu 
1               5                   10                  15      


Glu Thr Asn Thr Thr 
            20      


<210>  10
<211>  17
<212>  PRT
<213>  Adenovirus serotype 26


<220>
<221>  DOMAIN
<222>  (1)..(17)
<223>  HVR1

<400>  10

Thr Lys Glu Lys Gln Gly Thr Thr Gly Gly Val Gln Gln Glu Lys Asp 
1               5                   10                  15      


Val 
    


<210>  11
<211>  24
<212>  PRT
<213>  Adenovirus serotype 34


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  HVR1

<400>  11

Asp Lys Gly Val Thr Ser Thr Gly Leu Val Asp Asp Gly Asn Thr Asp 
1               5                   10                  15      


Asp Gly Glu Glu Ala Lys Lys Ala 
            20                  


<210>  12
<211>  24
<212>  PRT
<213>  Adenovirus serotype 35


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  HVR1

<400>  12

Ala Lys Gly Val Pro Thr Ala Ala Ala Ala Gly Asn Gly Glu Glu Glu 
1               5                   10                  15      


His Glu Thr Glu Glu Lys Thr Ala 
            20                  


<210>  13
<211>  14
<212>  PRT
<213>  Adenovirus serotype 48


<220>
<221>  DOMAIN
<222>  (1)..(14)
<223>  HVR1

<400>  13

Glu Lys Lys Asn Gly Gly Gly Ser Asp Ala Asn Gln Met Gln 
1               5                   10                  


<210>  14
<211>  11
<212>  PRT
<213>  Adenovirus serotype 49


<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  HVR1

<400>  14

Ala Lys Glu Asn Asn Gly Gln Gly Glu Ala Lys 
1               5                   10      


<210>  15
<211>  14
<212>  PRT
<213>  Adenovirus serotype 50


<220>
<221>  DOMAIN
<222>  (1)..(14)
<223>  HVR1

<400>  15

Asn Lys Gly Asp Glu Glu Asp Gly Glu Asp Asp Gln Gln Ala 
1               5                   10                  


<210>  16
<211>  11
<212>  PRT
<213>  Simian adenovirus serotype C68/Pan9


<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  HVR1

<400>  16

Tyr Lys Ala Asp Gly Glu Thr Ala Thr Glu Lys 
1               5                   10      


<210>  17
<211>  10
<212>  PRT
<213>  Adenovirus serotype 11


<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  HVR2

<400>  17

Leu Glu Val Ser Asp Glu Glu Ser Lys Pro 
1               5                   10  


<210>  18
<211>  11
<212>  PRT
<213>  Adenovirus serotype 26


<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  HVR2

<400>  18

Thr Asp Glu Thr Ala Glu Asn Gly Lys Lys Asp 
1               5                   10      


<210>  19
<211>  10
<212>  PRT
<213>  Adenovirus serotype 34


<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  HVR2

<400>  19

Leu Glu Val Ser Thr Glu Gly Pro Lys Pro 
1               5                   10  


<210>  20
<211>  11
<212>  PRT
<213>  Adenovirus serotype 35


<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  HVR2

<400>  20

Leu Glu Ile Ser Ala Glu Asn Glu Ser Lys Pro 
1               5                   10      


<210>  21
<211>  12
<212>  PRT
<213>  Adenovirus serotype 48


<220>
<221>  DOMAIN
<222>  (1)..(12)
<223>  HVR2

<400>  21

Ile Asp Ala Thr Lys Glu Glu Asp Asn Gly Lys Glu 
1               5                   10          


<210>  22
<211>  13
<212>  PRT
<213>  Adenovirus serotype 49


<220>
<221>  DOMAIN
<222>  (1)..(13)
<223>  HVR2

<400>  22

Ile Asp Glu Asn Lys Glu Glu Asp Glu Glu Gly Arg Glu 
1               5                   10              


<210>  23
<211>  11
<212>  PRT
<213>  Adenovirus serotype 50


<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  HVR2

<400>  23

Leu Glu Val Pro Ser Glu Gly Gly Pro Lys Pro 
1               5                   10      


<210>  24
<211>  7
<212>  PRT
<213>  Simian adenovirus serotype C68/Pan9


<220>
<221>  DOMAIN
<222>  (1)..(7)
<223>  HVR2

<400>  24

Thr Asp Thr Asp Asp Gln Pro 
1               5           


<210>  25
<211>  3
<212>  PRT
<213>  Adenovirus serotypes 11/34/35


<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  HVR3

<400>  25

Asp Leu Asp 
1           


<210>  26
<211>  3
<212>  PRT
<213>  Adenovirus serotype 26


<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  HVR3

<400>  26

Glu Asn Glu 
1           


<210>  27
<211>  3
<212>  PRT
<213>  Adenovirus serotype 48


<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  HVR3

<400>  27

Asp Ser Asp 
1           


<210>  28
<211>  3
<212>  PRT
<213>  Adenovirus serotype 49


<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  HVR3

<400>  28

Asn Thr Glu 
1           


<210>  29
<211>  3
<212>  PRT
<213>  Adenovirus serotype 50


<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  HVR3

<400>  29

Asp Thr Asp 
1           


<210>  30
<211>  3
<212>  PRT
<213>  Simian adenovirus serotype C68/Pan9


<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  HVR3

<400>  30

Asp Ile Thr 
1           


<210>  31
<211>  10
<212>  PRT
<213>  Adenovirus serotype 11


<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  HVR4

<400>  31

Lys Thr Thr Glu Gln Pro Asn Gln Lys Val 
1               5                   10  


<210>  32
<211>  10
<212>  PRT
<213>  Adenovirus serotype 26


<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  HVR4

<400>  32

Lys Pro Val Asn Glu Gly Glu Gln Pro Lys 
1               5                   10  


<210>  33
<211>  11
<212>  PRT
<213>  Adenovirus serotype 34


<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  HVR4

<400>  33

Lys Pro Lys Glu Asp Asp Gly Thr Asn Asn Ile 
1               5                   10      


<210>  34
<211>  10
<212>  PRT
<213>  Adenovirus serotype 35


<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  HVR4

<400>  34

Lys Asn Ser Glu Pro Ser Ser Glu Lys Ile 
1               5                   10  


<210>  35
<211>  11
<212>  PRT
<213>  Adenovirus serotype 48


<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  HVR4

<400>  35

Lys Thr Pro Glu Lys Glu Gly Glu Glu Pro Lys 
1               5                   10      


<210>  36
<211>  10
<212>  PRT
<213>  Adenovirus serotype 49


<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  HVR4

<400>  36

Lys Thr Gly Glu Asn Gly Lys Pro Thr Glu 
1               5                   10  


<210>  37
<211>  8
<212>  PRT
<213>  Adenovirus serotype 50


<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  HVR4

<400>  37

Lys Lys Glu Glu Glu Gly Lys Val 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Simian adenovirus serotype C68/Pan9


<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  HVR4

<400>  38

Lys Thr Gly Thr Gly Thr Thr Lys 
1               5               


<210>  39
<211>  9
<212>  PRT
<213>  Adenovirus serotype 11


<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  HVR5

<400>  39

Ala Ala Ser Gln Lys Thr Asn Leu Ser 
1               5                   


<210>  40
<211>  16
<212>  PRT
<213>  Adenovirus serotype 26


<220>
<221>  DOMAIN
<222>  (1)..(16)
<223>  HVR5

<400>  40

Val Pro Gly Gly Ser Pro Pro Ala Gly Gly Ser Gly Glu Glu Tyr Lys 
1               5                   10                  15      


<210>  41
<211>  9
<212>  PRT
<213>  Adenovirus serotype 34


<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  HVR5

<400>  41

Leu Arg Ser Gln Arg Ser Glu Leu Lys 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Adenovirus serotype 35


<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  HVR5

<400>  42

Asn Ser Ser Gln Arg Thr Asn Phe Ser 
1               5                   


<210>  43
<211>  16
<212>  PRT
<213>  Adenovirus serotype 48


<220>
<221>  DOMAIN
<222>  (1)..(16)
<223>  HVR5

<400>  43

Ile Pro Ser Thr Gly Thr Gly Gly Asn Gly Thr Asn Val Asn Phe Lys 
1               5                   10                  15      


<210>  44
<211>  12
<212>  PRT
<213>  Adenovirus serotype 49


<220>
<221>  DOMAIN
<222>  (1)..(12)
<223>  HVR5

<400>  44

Leu Arg Gln Asn Asp Thr Gly Gly Asn Asn Asn Gln 
1               5                   10          


<210>  45
<211>  9
<212>  PRT
<213>  Adenovirus serotype 50


<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  HVR5

<400>  45

Leu Arg Ser Gln Met Thr Gly Leu Lys 
1               5                   


<210>  46
<211>  10
<212>  PRT
<213>  Simian adenovirus serotype C68/Pan9


<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  HVR5

<400>  46

Asn Arg Ser Ala Ala Ala Ala Gly Leu Ala 
1               5                   10  


<210>  47
<211>  3
<212>  PRT
<213>  Adenovirus serotype 11/35


<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  HVR6

<400>  47

Thr Glu Asp 
1           


<210>  48
<211>  3
<212>  PRT
<213>  Adenovirus serotype 26/49


<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  HVR6

<400>  48

Thr Ser Asp 
1           


<210>  49
<211>  3
<212>  PRT
<213>  Adenovirus serotype 34


<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  HVR6

<400>  49

Val Ser Asp 
1           


<210>  50
<211>  3
<212>  PRT
<213>  Adenovirus serotype 48


<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  HVR6

<400>  50

Lys Glu Asp 
1           


<210>  51
<211>  3
<212>  PRT
<213>  Adenovirus serotype 50


<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  HVR6

<400>  51

Ala Ser Asp 
1           


<210>  52
<211>  3
<212>  PRT
<213>  Simian adenovirus serotype C68/Pan9


<220>
<221>  DOMAIN
<222>  (1)..(3)
<223>  HVR6

<400>  52

Thr Asp Asp 
1           


<210>  53
<211>  12
<212>  PRT
<213>  Adenovirus serotype 11


<220>
<221>  DOMAIN
<222>  (1)..(12)
<223>  HVR7

<400>  53

Asn Gly Asp Asn Ala Pro Asn Trp Lys Glu Pro Glu 
1               5                   10          


<210>  54
<211>  17
<212>  PRT
<213>  Adenovirus serotype 26


<220>
<221>  DOMAIN
<222>  (1)..(17)
<223>  HVR7

<400>  54

Thr Asn Gly Asn Asp Gly Ala Glu Glu Ser Glu Trp Glu Lys Asp Asp 
1               5                   10                  15      


Ala 
    


<210>  55
<211>  11
<212>  PRT
<213>  Adenovirus serotype 34


<220>
<221>  DOMAIN
<222>  (1)..(11)
<223>  HVR7

<400>  55

Asn Gly Asp Gln Ser Thr Trp Thr Asn Val Asp 
1               5                   10      


<210>  56
<211>  12
<212>  PRT
<213>  Adenovirus serotype 35


<220>
<221>  DOMAIN
<222>  (1)..(12)
<223>  HVR7

<400>  56

Asn Gly Glu Asp Asn Asn Asn Trp Lys Glu Pro Glu 
1               5                   10          


<210>  57
<211>  13
<212>  PRT
<213>  Adenovirus serotype 48


<220>
<221>  DOMAIN
<222>  (1)..(13)
<223>  HVR7

<400>  57

Lys Thr Thr Asn Asn Thr Glu Trp Glu Lys Asp Thr Ala 
1               5                   10              


<210>  58
<211>  16
<212>  PRT
<213>  Adenovirus serotype 49


<220>
<221>  DOMAIN
<222>  (1)..(16)
<223>  HVR7

<400>  58

Asp Thr Thr Val Ala Gly Thr Asn Asp Lys Trp Lys Val Asn Ala Lys 
1               5                   10                  15      


<210>  59
<211>  12
<212>  PRT
<213>  Adenovirus serotype 50


<220>
<221>  DOMAIN
<222>  (1)..(12)
<223>  HVR7

<400>  59

Asn Gly Asp Glu Thr Thr Thr Trp Lys Asp Leu Glu 
1               5                   10          


<210>  60
<211>  13
<212>  PRT
<213>  Simian adenovirus serotype C68/Pan9


<220>
<221>  DOMAIN
<222>  (1)..(13)
<223>  HVR7

<400>  60

Asn Gly Thr Asp Gln Thr Thr Trp Thr Lys Asp Asp Ser 
1               5                   10              


<210>  61
<211>  179
<212>  PRT
<213>  Simian adenovirus serotype C68/Pan9


<220>
<221>  DOMAIN
<222>  (1)..(179)
<223>  Fiber knob domain

<400>  61

Thr Leu Trp Thr Thr Pro Asp Pro Ser Pro Asn Cys Gln Ile Leu Ala 
1               5                   10                  15      


Glu Asn Asp Ala Lys Leu Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln 
            20                  25                  30          


Ile Leu Ala Thr Val Ser Val Leu Val Val Gly Ser Gly Asn Leu Asn 
        35                  40                  45              


Pro Ile Thr Gly Thr Val Ser Ser Ala Gln Val Phe Leu Arg Phe Asp 
    50                  55                  60                  


Ala Asn Gly Val Leu Leu Thr Glu His Ser Thr Leu Lys Lys Tyr Trp 
65                  70                  75                  80  


Gly Tyr Arg Gln Gly Asp Ser Ile Asp Gly Thr Pro Tyr Thr Asn Ala 
                85                  90                  95      


Val Gly Phe Met Pro Asn Leu Lys Ala Tyr Pro Lys Ser Gln Ser Ser 
            100                 105                 110         


Thr Thr Lys Asn Asn Ile Val Gly Gln Val Tyr Met Asn Gly Asp Val 
        115                 120                 125             


Ser Lys Pro Met Leu Leu Thr Ile Thr Leu Asn Gly Thr Asp Asp Ser 
    130                 135                 140                 


Asn Ser Thr Tyr Ser Met Ser Phe Ser Tyr Thr Trp Thr Asn Gly Ser 
145                 150                 155                 160 


Tyr Val Gly Ala Thr Phe Gly Ala Asn Ser Tyr Thr Phe Ser Tyr Ile 
                165                 170                 175     


Ala Gln Glu 
            


<210>  62
<211>  192
<212>  PRT
<213>  Adenovirus serotype 15


<220>
<221>  DOMAIN
<222>  (1)..(192)
<223>  Fiber knob domain

<400>  62

Thr Leu Trp Thr Thr Pro Asp Pro Ser Pro Asn Cys Arg Val Ser Glu 
1               5                   10                  15      


Asp Lys Asp Ser Lys Leu Thr Leu Ile Leu Thr Lys Cys Gly Ser Gln 
            20                  25                  30          


Ile Leu Ala Ser Phe Ser Leu Leu Val Val Lys Gly Thr Tyr Ala Thr 
        35                  40                  45              


Val Asp Lys Asn Thr Thr Asn Lys Gln Phe Ser Ile Lys Leu Leu Phe 
    50                  55                  60                  


Asp Ala Asn Gly Lys Leu Lys Ser Glu Ser Asn Leu Ser Gly Tyr Trp 
65                  70                  75                  80  


Asn Tyr Arg Ser Asp Asn Ser Val Val Ser Thr Pro Tyr Asp Asn Ala 
                85                  90                  95      


Val Pro Phe Met Pro Asn Thr Thr Ala Tyr Pro Lys Ile Ile Asn Ser 
            100                 105                 110         


Thr Thr Val Pro Glu Asn Lys Lys Ser Ser Ala Lys Lys Thr Ile Val 
        115                 120                 125             


Gly Asn Val Tyr Leu Glu Gly Asn Ala Gly Gln Pro Val Ala Val Ala 
    130                 135                 140                 


Ile Ser Phe Asn Lys Glu Thr Thr Ala Asp Tyr Ser Ile Thr Phe Asp 
145                 150                 155                 160 


Phe Ala Trp Ser Lys Ala Tyr Glu Thr Pro Val Pro Phe Asp Thr Ser 
                165                 170                 175     


Ser Met Thr Phe Ser Tyr Ile Ala Gln Glu Asn Gln Asp Lys Gly Glu 
            180                 185                 190         


<210>  63
<211>  947
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  DOMAIN
<222>  (1)..(947)
<223>  Adenovirus serotype 5 HVR48(1-7) chimeric hexon protein

<400>  63

Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser 
1               5                   10                  15      


Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 
            20                  25                  30          


Arg Ala Thr Glu Thr Tyr Phe Ser Leu Asn Asn Lys Phe Arg Asn Pro 
        35                  40                  45              


Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 
    50                  55                  60                  


Thr Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr 
65                  70                  75                  80  


Lys Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 
                85                  90                  95      


Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr 
            100                 105                 110         


Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly 
        115                 120                 125             


Ala Pro Asn Pro Cys Glu Trp Glu Glu Lys Lys Asn Gly Gly Gly Ser 
    130                 135                 140                 


Asp Ala Asn Gln Met Gln Thr His Val Phe Gly Gln Ala Pro Tyr Ser 
145                 150                 155                 160 


Gly Ile Asn Ile Thr Lys Glu Gly Ile Gln Ile Gly Ile Asp Ala Thr 
                165                 170                 175     


Lys Glu Glu Asp Asn Gly Lys Glu Ile Tyr Ala Asp Lys Thr Phe Gln 
            180                 185                 190         


Pro Glu Pro Gln Ile Gly Glu Ser Gln Trp Gln Asp Ser Asp Asn Tyr 
        195                 200                 205             


Tyr Gly Gly Arg Val Leu Lys Lys Thr Thr Pro Met Lys Pro Cys Tyr 
    210                 215                 220                 


Gly Ser Tyr Ala Lys Pro Thr Asn Glu Asn Gly Gly Gln Ala Lys Phe 
225                 230                 235                 240 


Lys Thr Pro Glu Lys Glu Gly Glu Glu Pro Lys Glu Ser Gln Val Glu 
                245                 250                 255     


Met Gln Phe Phe Asp Ile Pro Ser Thr Gly Thr Gly Gly Asn Gly Thr 
            260                 265                 270         


Asn Val Asn Phe Lys Pro Lys Val Val Leu Tyr Ser Glu Asp Val Asp 
        275                 280                 285             


Ile Glu Thr Pro Asp Thr His Ile Ser Tyr Met Pro Gly Lys Glu Asp 
    290                 295                 300                 


Ala Ser Ser Arg Glu Leu Met Gly Gln Gln Ser Met Pro Asn Arg Pro 
305                 310                 315                 320 


Asn Tyr Ile Ala Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn 
                325                 330                 335     


Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn 
            340                 345                 350         


Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu 
        355                 360                 365             


Leu Leu Asp Ser Ile Gly Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn 
    370                 375                 380                 


Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His 
385                 390                 395                 400 


Gly Thr Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asp Gly Ala 
                405                 410                 415     


Gly Thr Asn Ala Val Tyr Gln Gly Val Lys Val Lys Thr Thr Asn Asn 
            420                 425                 430         


Thr Glu Trp Glu Lys Asp Thr Ala Val Ser Glu His Asn Gln Ile Arg 
        435                 440                 445             


Val Gly Asn Asn Phe Ala Met Glu Ile Asn Leu Asn Ala Asn Leu Trp 
    450                 455                 460                 


Arg Asn Phe Leu Tyr Ser Asn Ile Ala Leu Tyr Leu Pro Asp Lys Leu 
465                 470                 475                 480 


Lys Tyr Ser Pro Ser Asn Val Lys Ile Ser Asp Asn Pro Asn Thr Tyr 
                485                 490                 495     


Asp Tyr Met Asn Lys Arg Val Val Ala Pro Gly Leu Val Asp Cys Tyr 
            500                 505                 510         


Ile Asn Leu Gly Ala Arg Trp Ser Leu Asp Tyr Met Asp Asn Val Asn 
        515                 520                 525             


Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu 
    530                 535                 540                 


Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys 
545                 550                 555                 560 


Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr 
                565                 570                 575     


Glu Trp Asn Phe Arg Lys Asp Val Asn Met Val Leu Gln Ser Ser Leu 
            580                 585                 590         


Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile Lys Phe Asp Ser Ile 
        595                 600                 605             


Cys Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr 
    610                 615                 620                 


Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp 
625                 630                 635                 640 


Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr 
                645                 650                 655     


Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly 
            660                 665                 670         


Trp Ala Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser 
        675                 680                 685             


Gly Tyr Asp Pro Tyr Tyr Thr Tyr Ser Gly Ser Ile Pro Tyr Leu Asp 
    690                 695                 700                 


Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ala Ile Thr Phe 
705                 710                 715                 720 


Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn 
                725                 730                 735     


Glu Phe Glu Ile Lys Arg Ser Val Asp Gly Glu Gly Tyr Asn Val Ala 
            740                 745                 750         


Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala Asn 
        755                 760                 765             


Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Ile Pro Glu Ser Tyr Lys Asp 
    770                 775                 780                 


Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val 
785                 790                 795                 800 


Val Asp Asp Thr Lys Tyr Lys Asp Tyr Gln Gln Val Gly Ile Leu His 
                805                 810                 815     


Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg 
            820                 825                 830         


Glu Gly Gln Ala Tyr Pro Ala Asn Phe Pro Tyr Pro Leu Ile Gly Lys 
        835                 840                 845             


Thr Ala Val Asp Ser Ile Thr Gln Lys Lys Phe Leu Cys Asp Arg Thr 
    850                 855                 860                 


Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu 
865                 870                 875                 880 


Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn Ser Ala His Ala Leu 
                885                 890                 895     


Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu Pro Thr Leu Leu Tyr 
            900                 905                 910         


Val Leu Phe Glu Val Phe Asp Val Val Arg Val His Arg Pro His Arg 
        915                 920                 925             


Gly Val Ile Glu Thr Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn 
    930                 935                 940                 


Ala Thr Thr 
945         


<210>  64
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  DOMAIN
<222>  (1)..(578)
<223>  Adenovirus serotype 5 KC68 chimeric fiber protein

<400>  64

Met Lys Arg Ala Arg Pro Ser Glu Asp Thr Phe Asn Pro Val Tyr Pro 
1               5                   10                  15      


Tyr Asp Thr Glu Thr Gly Pro Pro Thr Val Pro Phe Leu Thr Pro Pro 
            20                  25                  30          


Phe Val Ser Pro Asn Gly Phe Gln Glu Ser Pro Pro Gly Val Leu Ser 
        35                  40                  45              


Leu Arg Leu Ser Glu Pro Leu Val Thr Ser Asn Gly Met Leu Ala Leu 
    50                  55                  60                  


Lys Met Gly Asn Gly Leu Ser Leu Asp Glu Ala Gly Asn Leu Thr Ser 
65                  70                  75                  80  


Gln Asn Val Thr Thr Val Ser Pro Pro Leu Lys Lys Thr Lys Ser Asn 
                85                  90                  95      


Ile Asn Leu Glu Ile Ser Ala Pro Leu Thr Val Thr Ser Glu Ala Leu 
            100                 105                 110         


Thr Val Ala Ala Ala Ala Pro Leu Met Val Ala Gly Asn Thr Leu Thr 
        115                 120                 125             


Met Gln Ser Gln Ala Pro Leu Thr Val His Asp Ser Lys Leu Ser Ile 
    130                 135                 140                 


Ala Thr Gln Gly Pro Leu Thr Val Ser Glu Gly Lys Leu Ala Leu Gln 
145                 150                 155                 160 


Thr Ser Gly Pro Leu Thr Thr Thr Asp Ser Ser Thr Leu Thr Ile Thr 
                165                 170                 175     


Ala Ser Pro Pro Leu Thr Thr Ala Thr Gly Ser Leu Gly Ile Asp Leu 
            180                 185                 190         


Lys Glu Pro Ile Tyr Thr Gln Asn Gly Lys Leu Gly Leu Lys Tyr Gly 
        195                 200                 205             


Ala Pro Leu His Val Thr Asp Asp Leu Asn Thr Leu Thr Val Ala Thr 
    210                 215                 220                 


Gly Pro Gly Val Thr Ile Asn Asn Thr Ser Leu Gln Thr Lys Val Thr 
225                 230                 235                 240 


Gly Ala Leu Gly Phe Asp Ser Gln Gly Asn Met Gln Leu Asn Val Ala 
                245                 250                 255     


Gly Gly Leu Arg Ile Asp Ser Gln Asn Arg Arg Leu Ile Leu Asp Val 
            260                 265                 270         


Ser Tyr Pro Phe Asp Ala Gln Asn Gln Leu Asn Leu Arg Leu Gly Gln 
        275                 280                 285             


Gly Pro Leu Phe Ile Asn Ser Ala His Asn Leu Asp Ile Asn Tyr Asn 
    290                 295                 300                 


Lys Gly Leu Tyr Leu Phe Thr Ala Ser Asn Asn Ser Lys Lys Leu Glu 
305                 310                 315                 320 


Val Asn Leu Ser Thr Ala Lys Gly Leu Met Phe Asp Ala Thr Ala Ile 
                325                 330                 335     


Ala Ile Asn Ala Gly Asp Gly Leu Glu Phe Gly Ser Pro Asn Ala Pro 
            340                 345                 350         


Asn Thr Asn Pro Leu Lys Thr Lys Ile Gly His Gly Leu Glu Phe Asp 
        355                 360                 365             


Ser Asn Lys Ala Met Val Pro Lys Leu Gly Thr Gly Leu Ser Phe Asp 
    370                 375                 380                 


Ser Thr Gly Ala Ile Thr Val Gly Asn Lys Asn Asn Asp Lys Leu Thr 
385                 390                 395                 400 


Leu Trp Thr Thr Pro Asp Pro Ser Pro Asn Cys Gln Ile Leu Ala Glu 
                405                 410                 415     


Asn Asp Ala Lys Leu Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile 
            420                 425                 430         


Leu Ala Thr Val Ser Val Leu Val Val Gly Ser Gly Asn Leu Asn Pro 
        435                 440                 445             


Ile Thr Gly Thr Val Ser Ser Ala Gln Val Phe Leu Arg Phe Asp Ala 
    450                 455                 460                 


Asn Gly Val Leu Leu Thr Glu His Ser Thr Leu Lys Lys Tyr Trp Gly 
465                 470                 475                 480 


Tyr Arg Gln Gly Asp Ser Ile Asp Gly Thr Pro Tyr Thr Asn Ala Val 
                485                 490                 495     


Gly Phe Met Pro Asn Leu Lys Ala Tyr Pro Lys Ser Gln Ser Ser Thr 
            500                 505                 510         


Thr Lys Asn Asn Ile Val Gly Gln Val Tyr Met Asn Gly Asp Val Ser 
        515                 520                 525             


Lys Pro Met Leu Leu Thr Ile Thr Leu Asn Gly Thr Asp Asp Ser Asn 
    530                 535                 540                 


Ser Thr Tyr Ser Met Ser Phe Ser Tyr Thr Trp Thr Asn Gly Ser Tyr 
545                 550                 555                 560 


Val Gly Ala Thr Phe Gly Ala Asn Ser Tyr Thr Phe Ser Tyr Ile Ala 
                565                 570                 575     


Gln Glu 
        


