                         SEQUENCE LISTING

<110>  Bioceros B.V.
 
<120>  ANTI-CD134 (OX40) ANTIBODIES AND USES THEREOF

<130>  BIOBF/P51941PC

<150>  GB 1116092.6
<151>  2011-09-16

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  277
<212>  PRT
<213>  Homo sapiens

<220>
<221>   SIGNAL
<222>   (1)...(28)

<220>
<221>   TRANSMEM
<222>   (215)...(235)

<400>  1

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  2
<211>  834
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sf9 insect cell-optimized cDNA sequence for human CD134

<400>  2

Ala Thr Gly Thr Gly Cys Gly Thr Gly Gly Gly Cys Gly Cys Thr Cys 
1               5                   10                  15      


Gly Thr Cys Gly Thr Cys Thr Gly Gly Gly Thr Cys Gly Thr Gly Gly 
            20                  25                  30          


Thr Cys Cys Cys Thr Gly Cys Gly Cys Thr Gly Cys Thr Cys Thr Gly 
        35                  40                  45              


Cys Thr Gly Cys Thr Gly Cys Thr Gly Gly Gly Thr Cys Thr Gly Gly 
    50                  55                  60                  


Gly Cys Cys Thr Gly Thr Cys Cys Ala Cys Thr Gly Thr Cys Ala Cys 
65                  70                  75                  80  


Thr Gly Gly Ala Cys Thr Cys Cys Ala Cys Thr Gly Cys Gly Thr Gly 
                85                  90                  95      


Gly Gly Cys Gly Ala Cys Ala Cys Cys Thr Ala Cys Cys Cys Cys Thr 
            100                 105                 110         


Cys Cys Ala Ala Cys Gly Ala Cys Cys Gly Thr Thr Gly Cys Thr Gly 
        115                 120                 125             


Cys Cys Ala Cys Gly Ala Ala Thr Gly Cys Ala Gly Gly Cys Cys Thr 
    130                 135                 140                 


Gly Gly Cys Ala Ala Cys Gly Gly Cys Ala Thr Gly Gly Thr Gly Thr 
145                 150                 155                 160 


Cys Cys Cys Gly Thr Thr Gly Cys Thr Cys Cys Cys Gly Thr Thr Cys 
                165                 170                 175     


Cys Cys Ala Gly Ala Ala Cys Ala Cys Cys Gly Thr Gly Thr Gly Cys 
            180                 185                 190         


Cys Gly Thr Cys Cys Cys Thr Gly Cys Gly Gly Thr Cys Cys Cys Gly 
        195                 200                 205             


Gly Thr Thr Thr Cys Thr Ala Cys Ala Ala Cys Gly Ala Cys Gly Thr 
    210                 215                 220                 


Gly Gly Thr Gly Thr Cys Cys Thr Cys Cys Ala Ala Gly Cys Cys Cys 
225                 230                 235                 240 


Thr Gly Cys Ala Ala Gly Cys Cys Thr Thr Gly Cys Ala Cys Thr Thr 
                245                 250                 255     


Gly Gly Thr Gly Thr Ala Ala Cys Cys Thr Cys Cys Gly Cys Thr Cys 
            260                 265                 270         


Cys Gly Gly Thr Thr Cys Cys Gly Ala Gly Cys Gly Cys Ala Ala Gly 
        275                 280                 285             


Cys Ala Gly Cys Thr Gly Thr Gly Cys Ala Cys Cys Gly Cys Thr Ala 
    290                 295                 300                 


Cys Cys Cys Ala Gly Gly Ala Cys Ala Cys Thr Gly Thr Cys Thr Gly 
305                 310                 315                 320 


Thr Ala Gly Gly Thr Gly Cys Ala Gly Gly Gly Cys Thr Gly Gly Cys 
                325                 330                 335     


Ala Cys Cys Cys Ala Gly Cys Cys Cys Cys Thr Gly Gly Ala Cys Thr 
            340                 345                 350         


Cys Cys Thr Ala Cys Ala Ala Gly Cys Cys Cys Gly Gly Thr Gly Thr 
        355                 360                 365             


Cys Gly Ala Cys Thr Gly Cys Gly Cys Thr Cys Cys Cys Thr Gly Cys 
    370                 375                 380                 


Cys Cys Cys Cys Cys Thr Gly Gly Thr Cys Ala Cys Thr Thr Cys Thr 
385                 390                 395                 400 


Cys Thr Cys Cys Cys Gly Gly Cys Gly Ala Cys Ala Ala Cys Cys Ala 
                405                 410                 415     


Gly Gly Cys Thr Thr Gly Cys Ala Ala Ala Cys Cys Ala Thr Gly Gly 
            420                 425                 430         


Ala Cys Cys Ala Ala Cys Thr Gly Cys Ala Cys Cys Cys Thr Gly Gly 
        435                 440                 445             


Cys Thr Gly Gly Cys Ala Ala Gly Cys Ala Cys Ala Cys Cys Cys Thr 
    450                 455                 460                 


Gly Cys Ala Gly Cys Cys Cys Gly Cys Thr Thr Cys Cys Ala Ala Cys 
465                 470                 475                 480 


Thr Cys Cys Thr Cys Cys Gly Ala Cys Gly Cys Thr Ala Thr Cys Thr 
                485                 490                 495     


Gly Cys Gly Ala Gly Gly Ala Cys Cys Gly Thr Gly Ala Cys Cys Cys 
            500                 505                 510         


Cys Cys Cys Thr Gly Cys Thr Ala Cys Thr Cys Ala Ala Cys Cys Thr 
        515                 520                 525             


Cys Ala Gly Gly Ala Gly Ala Cys Thr Cys Ala Gly Gly Gly Thr Cys 
    530                 535                 540                 


Cys Cys Cys Cys Cys Gly Cys Thr Cys Gly Thr Cys Cys Cys Ala Thr 
545                 550                 555                 560 


Cys Ala Cys Cys Gly Thr Gly Cys Ala Gly Cys Cys Cys Ala Cys Cys 
                565                 570                 575     


Gly Ala Gly Gly Cys Thr Thr Gly Gly Cys Cys Cys Cys Gly Thr Ala 
            580                 585                 590         


Cys Cys Thr Cys Cys Cys Ala Ala Gly Gly Ala Cys Cys Thr Ala Gly 
        595                 600                 605             


Cys Ala Cys Thr Ala Gly Gly Cys Cys Thr Gly Thr Gly Gly Ala Gly 
    610                 615                 620                 


Gly Thr Gly Cys Cys Cys Gly Gly Thr Gly Gly Thr Cys Gly Thr Gly 
625                 630                 635                 640 


Cys Thr Gly Thr Gly Gly Cys Thr Gly Cys Thr Ala Thr Cys Cys Thr 
                645                 650                 655     


Gly Gly Gly Cys Cys Thr Gly Gly Gly Thr Cys Thr Gly Gly Thr Gly 
            660                 665                 670         


Cys Thr Gly Gly Gly Cys Cys Thr Gly Cys Thr Gly Gly Gly Thr Cys 
        675                 680                 685             


Cys Cys Cys Thr Gly Gly Cys Thr Ala Thr Cys Cys Thr Gly Cys Thr 
    690                 695                 700                 


Gly Gly Cys Thr Cys Thr Gly Thr Ala Cys Cys Thr Cys Cys Thr Gly 
705                 710                 715                 720 


Cys Gly Thr Cys Gly Thr Gly Ala Cys Cys Ala Gly Cys Gly Thr Cys 
                725                 730                 735     


Thr Gly Cys Cys Cys Cys Cys Cys Gly Ala Cys Gly Cys Thr Cys Ala 
            740                 745                 750         


Cys Ala Ala Gly Cys Cys Cys Cys Cys Thr Gly Gly Thr Gly Gly Thr 
        755                 760                 765             


Gly Gly Thr Thr Cys Cys Thr Thr Cys Cys Gly Thr Ala Cys Cys Cys 
    770                 775                 780                 


Cys Cys Ala Thr Cys Cys Ala Gly Gly Ala Gly Gly Ala Gly Cys Ala 
785                 790                 795                 800 


Gly Gly Cys Thr Gly Ala Cys Gly Cys Thr Cys Ala Cys Thr Cys Cys 
                805                 810                 815     


Ala Cys Cys Cys Thr Gly Gly Cys Cys Ala Ala Gly Ala Thr Cys Thr 
            820                 825                 830         


Ala Ala 
        


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminus amino acid sequence of clone 20E5 heavy chain

<400>  3

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
1               5                   10      


<210>  4
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 20E5 heavy chain variable region

<400>  4

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Tyr Gly Ser Ser Leu Ser Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  5
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 20E5 light chain variable region

<400>  5

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 20E5 heavy chain CDR1

<400>  6

Gly Tyr Thr Phe Thr Ser Tyr Val Met His 
1               5                   10  


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 20E5 heavy chain CDR2

<400>  7

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 20E5 heavy chain CDR3

<400>  8

Tyr Tyr Gly Ser Ser Leu Ser Met Asp Tyr 
1               5                   10  


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 20E5 light chain CDR1

<400>  9

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 20E5 light chain CDR2

<400>  10

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 20E5 light chain CDR3

<400>  11

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  12
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 12H3 heavy chain variable region

<400>  12

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Lys Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Tyr His Gly Pro His Leu Asp Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Pro 
        115                 120     


<210>  13
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 12H3 light chain variable region

<400>  13

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ala Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Thr Asp Tyr Phe Cys Gln Gln Tyr Ile Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 12H3 heavy chain CDR1

<400>  14

Gly Tyr Thr Phe Lys Asp Tyr Thr Met His 
1               5                   10  


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 12H3 heavy chain CDR2

<400>  15

Gly Ile Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 12H3 heavy chain CDR3

<400>  16

Met Gly Tyr His Gly Pro His Leu Asp Phe Asp Val 
1               5                   10          


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 12H3 light chain CDR1

<400>  17

Lys Ala Ser Gln Asp Val Gly Ala Ala Val Ala 
1               5                   10      


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 12H3 light chain CDR2

<400>  18

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of clone 12H3 light chain CDR3

<400>  19

Gln Gln Tyr Ile Asn Tyr Pro Leu Thr 
1               5                   


<210>  20
<211>  1398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHO-optimized cDNA sequence coding for chimeric clone 20E5 human 
       IgG4 chain

<400>  20

Ala Thr Gly Gly Ala Gly Thr Gly Gly Ala Gly Cys Gly Gly Ala Gly 
1               5                   10                  15      


Thr Gly Thr Thr Thr Ala Thr Gly Thr Thr Cys Cys Thr Gly Cys Thr 
            20                  25                  30          


Gly Ala Gly Cys Gly Thr Gly Ala Cys Cys Gly Cys Thr Gly Gly Cys 
        35                  40                  45              


Gly Thr Gly Cys Ala Cys Thr Cys Ala Gly Ala Gly Gly Thr Gly Cys 
    50                  55                  60                  


Ala Gly Cys Thr Gly Cys Ala Gly Cys Ala Gly Thr Cys Ala Gly Gly 
65                  70                  75                  80  


Cys Cys Cys Cys Gly Ala Gly Cys Thr Gly Gly Thr Cys Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Cys Gly Cys Thr Ala Gly Cys Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Ala Thr Gly Ala Gly Cys Thr Gly Thr Ala Ala Ala Gly Cys 
        115                 120                 125             


Thr Ala Gly Cys Gly Gly Cys Thr Ala Cys Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Cys Thr Ala Gly Cys Thr Ala Cys Gly Thr Gly Ala Thr Gly Cys 
145                 150                 155                 160 


Ala Cys Thr Gly Gly Gly Thr Cys Ala Ala Gly Cys Ala Gly Ala Ala 
                165                 170                 175     


Gly Cys Cys Cys Gly Gly Cys Cys Ala Gly Gly Gly Cys Cys Thr Gly 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Cys Gly Gly Cys Thr Ala Thr Ala 
        195                 200                 205             


Thr Thr Ala Ala Cys Cys Cys Cys Thr Ala Thr Ala Ala Cys Gly Ala 
    210                 215                 220                 


Cys Gly Gly Cys Ala Cys Thr Ala Ala Gly Thr Ala Thr Ala Ala Cys 
225                 230                 235                 240 


Gly Ala Gly Ala Ala Gly Thr Thr Thr Ala Ala Gly Gly Gly Cys Ala 
                245                 250                 255     


Ala Gly Gly Cys Thr Ala Cys Cys Cys Thr Gly Ala Cys Thr Ala Gly 
            260                 265                 270         


Cys Gly Ala Thr Ala Ala Gly Thr Cys Thr Ala Gly Cys Thr Cys Thr 
        275                 280                 285             


Ala Cys Cys Gly Cys Cys Thr Ala Thr Ala Thr Gly Gly Ala Ala Cys 
    290                 295                 300                 


Thr Gly Thr Cys Thr Ala Gly Thr Cys Thr Gly Ala Cys Thr Ala Gly 
305                 310                 315                 320 


Thr Gly Ala Ala Gly Ala Thr Ala Gly Cys Gly Cys Cys Gly Thr Cys 
                325                 330                 335     


Thr Ala Cys Thr Ala Cys Thr Gly Cys Gly Cys Thr Ala Ala Cys Thr 
            340                 345                 350         


Ala Cys Thr Ala Cys Gly Gly Cys Thr Cys Thr Ala Gly Cys Cys Thr 
        355                 360                 365             


Gly Thr Cys Thr Ala Thr Gly Gly Ala Cys Thr Ala Cys Thr Gly Gly 
    370                 375                 380                 


Gly Gly Cys Cys Ala Gly Gly Gly Cys Ala Cys Thr Ala Gly Cys Gly 
385                 390                 395                 400 


Thr Gly Ala Cys Cys Gly Thr Gly Thr Cys Thr Ala Gly Cys Gly Cys 
                405                 410                 415     


Thr Ala Gly Cys Ala Cys Thr Ala Ala Gly Gly Gly Cys Cys Cys Thr 
            420                 425                 430         


Ala Gly Cys Gly Thr Gly Thr Thr Cys Cys Cys Cys Cys Thr Gly Gly 
        435                 440                 445             


Cys Cys Cys Cys Cys Thr Gly Cys Thr Cys Thr Ala Gly Ala Thr Cys 
    450                 455                 460                 


Thr Ala Cys Thr Ala Gly Cys Gly Ala Gly Thr Cys Thr Ala Cys Cys 
465                 470                 475                 480 


Gly Cys Cys Gly Cys Thr Cys Thr Gly Gly Gly Cys Thr Gly Cys Cys 
                485                 490                 495     


Thr Gly Gly Thr Cys Ala Ala Gly Gly Ala Cys Thr Ala Cys Thr Thr 
            500                 505                 510         


Cys Cys Cys Cys Gly Ala Gly Cys Cys Cys Gly Thr Gly Ala Cys Cys 
        515                 520                 525             


Gly Thr Cys Ala Gly Cys Thr Gly Gly Ala Ala Thr Ala Gly Cys Gly 
    530                 535                 540                 


Gly Cys Gly Cys Thr Cys Thr Gly Ala Cys Thr Ala Gly Cys Gly Gly 
545                 550                 555                 560 


Cys Gly Thr Gly Cys Ala Cys Ala Cys Cys Thr Thr Cys Cys Cys Thr 
                565                 570                 575     


Gly Cys Cys Gly Thr Gly Cys Thr Gly Cys Ala Gly Thr Cys Thr Ala 
            580                 585                 590         


Gly Cys Gly Gly Cys Cys Thr Gly Thr Ala Thr Ala Gly Thr Cys Thr 
        595                 600                 605             


Gly Thr Cys Thr Ala Gly Cys Gly Thr Gly Gly Thr Cys Ala Cys Cys 
    610                 615                 620                 


Gly Thr Gly Cys Cys Thr Ala Gly Thr Thr Cys Thr Ala Gly Cys Cys 
625                 630                 635                 640 


Thr Gly Gly Gly Cys Ala Cys Thr Ala Ala Gly Ala Cys Cys Thr Ala 
                645                 650                 655     


Cys Ala Cys Cys Thr Gly Thr Ala Ala Cys Gly Thr Gly Gly Ala Cys 
            660                 665                 670         


Cys Ala Cys Ala Ala Gly Cys Cys Cys Thr Cys Thr Ala Ala Cys Ala 
        675                 680                 685             


Cys Thr Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Gly Cys Gly 
    690                 695                 700                 


Gly Gly Thr Gly Gly Ala Ala Thr Cys Thr Ala Ala Gly Thr Ala Cys 
705                 710                 715                 720 


Gly Gly Cys Cys Cys Thr Cys Cys Cys Thr Gly Cys Cys Cys Cys Cys 
                725                 730                 735     


Cys Cys Thr Gly Cys Cys Cys Thr Gly Cys Cys Cys Cys Thr Gly Ala 
            740                 745                 750         


Ala Thr Thr Thr Cys Thr Gly Gly Gly Cys Gly Gly Ala Cys Cys Thr 
        755                 760                 765             


Ala Gly Thr Gly Thr Gly Thr Thr Cys Cys Thr Gly Thr Thr Cys Cys 
    770                 775                 780                 


Cys Ala Cys Cys Thr Ala Ala Gly Cys Cys Thr Ala Ala Gly Gly Ala 
785                 790                 795                 800 


Cys Ala Cys Cys Cys Thr Gly Ala Thr Gly Ala Thr Cys Thr Cys Thr 
                805                 810                 815     


Ala Gly Ala Ala Cys Cys Cys Cys Cys Gly Ala Ala Gly Thr Gly Ala 
            820                 825                 830         


Cys Cys Thr Gly Cys Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly Ala 
        835                 840                 845             


Cys Gly Thr Gly Thr Cys Ala Cys Ala Gly Gly Ala Ala Gly Ala Thr 
    850                 855                 860                 


Cys Cys Cys Gly Ala Gly Gly Thr Cys Cys Ala Gly Thr Thr Thr Ala 
865                 870                 875                 880 


Ala Thr Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly 
                885                 890                 895     


Cys Gly Thr Gly Gly Ala Ala Gly Thr Gly Cys Ala Cys Ala Ala Cys 
            900                 905                 910         


Gly Cys Thr Ala Ala Gly Ala Cys Thr Ala Ala Gly Cys Cys Thr Ala 
        915                 920                 925             


Gly Ala Gly Ala Gly Gly Ala Ala Cys Ala Gly Thr Thr Thr Ala Ala 
    930                 935                 940                 


Cys Thr Cys Thr Ala Cys Cys Thr Ala Thr Ala Gly Gly Gly Thr Cys 
945                 950                 955                 960 


Gly Thr Cys Ala Gly Cys Gly Thr Gly Cys Thr Gly Ala Cys Cys Gly 
                965                 970                 975     


Thr Gly Cys Thr Gly Cys Ala Cys Cys Ala Gly Gly Ala Cys Thr Gly 
            980                 985                 990         


Gly Cys Thr Gly Ala Ala Cys Gly  Gly Cys Ala Ala Ala  Gly Ala Gly 
        995                 1000                 1005             


Thr Ala  Thr Ala Ala Gly Thr  Gly Thr Ala Ala Ala  Gly Thr Gly 
    1010                 1015                 1020             


Thr Cys  Thr Ala Ala Cys Ala  Ala Gly Gly Gly Cys  Cys Thr Gly 
    1025                 1030                 1035             


Cys Cys  Thr Ala Gly Cys Thr  Cys Thr Ala Thr Cys  Gly Ala Ala 
    1040                 1045                 1050             


Ala Ala  Gly Ala Cys Thr Ala  Thr Cys Thr Cys Thr  Ala Ala Gly 
    1055                 1060                 1065             


Gly Cys  Thr Ala Ala Gly Gly  Gly Cys Cys Ala Gly  Cys Cys Thr 
    1070                 1075                 1080             


Ala Gly  Ala Gly Ala Ala Cys  Cys Thr Cys Ala Gly  Gly Thr Cys 
    1085                 1090                 1095             


Thr Ala  Cys Ala Cys Cys Cys  Thr Gly Cys Cys Cys  Cys Cys Thr 
    1100                 1105                 1110             


Ala Gly  Thr Cys Ala Gly Gly  Ala Ala Gly Ala Gly  Ala Thr Gly 
    1115                 1120                 1125             


Ala Cys  Thr Ala Ala Gly Ala  Ala Thr Cys Ala Gly  Gly Thr Gly 
    1130                 1135                 1140             


Thr Cys  Ala Cys Thr Gly Ala  Cys Cys Thr Gly Thr  Cys Thr Gly 
    1145                 1150                 1155             


Gly Thr  Cys Ala Ala Gly Gly  Gly Cys Thr Thr Cys  Thr Ala Cys 
    1160                 1165                 1170             


Cys Cys  Thr Ala Gly Cys Gly  Ala Thr Ala Thr Cys  Gly Cys Cys 
    1175                 1180                 1185             


Gly Thr  Cys Gly Ala Gly Thr  Gly Gly Gly Ala Gly  Thr Cys Thr 
    1190                 1195                 1200             


Ala Ala  Cys Gly Gly Cys Cys  Ala Gly Cys Cys Cys  Gly Ala Gly 
    1205                 1210                 1215             


Ala Ala  Cys Ala Ala Cys Thr  Ala Thr Ala Ala Gly  Ala Cys Thr 
    1220                 1225                 1230             


Ala Cys  Cys Cys Cys Cys Cys  Cys Thr Gly Thr Gly  Cys Thr Gly 
    1235                 1240                 1245             


Gly Ala  Thr Ala Gly Cys Gly  Ala Cys Gly Gly Thr  Ala Gly Cys 
    1250                 1255                 1260             


Thr Thr  Cys Thr Thr Cys Cys  Thr Gly Thr Ala Cys  Thr Cys Ala 
    1265                 1270                 1275             


Cys Gly  Gly Cys Thr Gly Ala  Cys Cys Gly Thr Gly  Gly Ala Thr 
    1280                 1285                 1290             


Ala Ala  Gly Thr Cys Thr Ala  Gly Gly Thr Gly Gly  Cys Ala Gly 
    1295                 1300                 1305             


Gly Ala  Ala Gly Gly Cys Ala  Ala Cys Gly Thr Cys  Thr Thr Thr 
    1310                 1315                 1320             


Ala Gly  Cys Thr Gly Thr Ala  Gly Cys Gly Thr Gly  Ala Thr Gly 
    1325                 1330                 1335             


Cys Ala  Cys Gly Ala Gly Gly  Cys Cys Cys Thr Gly  Cys Ala Cys 
    1340                 1345                 1350             


Ala Ala  Thr Cys Ala Cys Thr  Ala Cys Ala Cys Thr  Cys Ala Gly 
    1355                 1360                 1365             


Ala Ala  Gly Thr Cys Ala Cys  Thr Gly Ala Gly Cys  Cys Thr Gly 
    1370                 1375                 1380             


Ala Gly  Cys Cys Thr Gly Gly  Gly Cys Ala Ala Gly  Thr Gly Ala 
    1385                 1390                 1395             


<210>  21
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHO-optimized cDNA sequence coding for chimeric clone 20E5 human 
       kappa chain

<400>  21

Ala Thr Gly Gly Ala Gly Thr Gly Gly Ala Gly Cys Gly Gly Ala Gly 
1               5                   10                  15      


Thr Gly Thr Thr Thr Ala Thr Gly Thr Thr Cys Cys Thr Gly Cys Thr 
            20                  25                  30          


Gly Ala Gly Cys Gly Thr Gly Ala Cys Cys Gly Cys Thr Gly Gly Cys 
        35                  40                  45              


Gly Thr Gly Cys Ala Cys Thr Cys Ala Gly Ala Thr Ala Thr Thr Cys 
    50                  55                  60                  


Ala Gly Ala Thr Gly Ala Cys Thr Cys Ala Gly Ala Cys Thr Ala Cys 
65                  70                  75                  80  


Cys Thr Cys Thr Ala Gly Cys Cys Thr Gly Ala Gly Cys Gly Cys Thr 
                85                  90                  95      


Ala Gly Cys Cys Thr Gly Gly Gly Cys Gly Ala Thr Ala Gly Ala Gly 
            100                 105                 110         


Thr Gly Ala Cys Thr Ala Thr Thr Ala Gly Cys Thr Gly Thr Ala Gly 
        115                 120                 125             


Ala Gly Cys Thr Ala Gly Thr Cys Ala Gly Gly Ala Thr Ala Thr Cys 
    130                 135                 140                 


Thr Cys Thr Ala Ala Cys Thr Ala Cys Cys Thr Gly Ala Ala Cys Thr 
145                 150                 155                 160 


Gly Gly Thr Ala Thr Cys Ala Gly Cys Ala Gly Ala Ala Ala Cys Cys 
                165                 170                 175     


Cys Gly Ala Cys Gly Gly Cys Ala Cys Cys Gly Thr Gly Ala Ala Gly 
            180                 185                 190         


Cys Thr Gly Cys Thr Gly Ala Thr Cys Thr Ala Cys Thr Ala Cys Ala 
        195                 200                 205             


Cys Cys Thr Cys Thr Ala Gly Ala Cys Thr Gly Cys Ala Cys Thr Cys 
    210                 215                 220                 


Ala Gly Gly Cys Gly Thr Gly Cys Cys Cys Thr Cys Thr Ala Gly Gly 
225                 230                 235                 240 


Thr Thr Thr Ala Gly Cys Gly Gly Thr Ala Gly Cys Gly Gly Thr Ala 
                245                 250                 255     


Gly Thr Gly Gly Cys Ala Cys Cys Gly Ala Cys Thr Ala Thr Ala Gly 
            260                 265                 270         


Cys Cys Thr Gly Ala Cys Thr Ala Thr Cys Thr Cys Thr Ala Ala Cys 
        275                 280                 285             


Cys Thr Gly Gly Ala Ala Cys Ala Gly Gly Ala Ala Gly Ala Thr Ala 
    290                 295                 300                 


Thr Cys Gly Cys Thr Ala Cys Cys Thr Ala Cys Thr Thr Cys Thr Gly 
305                 310                 315                 320 


Thr Cys Ala Gly Cys Ala Gly Gly Gly Cys Ala Ala Cys Ala Cys Cys 
                325                 330                 335     


Cys Thr Gly Cys Cys Cys Thr Gly Gly Ala Cys Cys Thr Thr Cys Gly 
            340                 345                 350         


Gly Cys Gly Gly Ala Gly Gly Cys Ala Cys Thr Ala Ala Gly Cys Thr 
        355                 360                 365             


Gly Gly Ala Ala Ala Thr Cys Ala Ala Gly Cys Gly Gly Ala Cys Cys 
    370                 375                 380                 


Gly Thr Gly Gly Cys Cys Gly Cys Thr Cys Cys Cys Thr Cys Ala Gly 
385                 390                 395                 400 


Thr Gly Thr Thr Thr Ala Thr Cys Thr Thr Cys Cys Cys Ala Cys Cys 
                405                 410                 415     


Thr Ala Gly Cys Gly Ala Cys Gly Ala Gly Cys Ala Gly Cys Thr Gly 
            420                 425                 430         


Ala Ala Gly Thr Cys Cys Gly Gly Cys Ala Cys Cys Gly Cys Thr Ala 
        435                 440                 445             


Gly Cys Gly Thr Cys Gly Thr Gly Thr Gly Cys Cys Thr Gly Cys Thr 
    450                 455                 460                 


Gly Ala Ala Cys Ala Ala Cys Thr Thr Cys Thr Ala Cys Cys Cys Thr 
465                 470                 475                 480 


Ala Gly Ala Gly Ala Ala Gly Cys Thr Ala Ala Gly Gly Thr Gly Cys 
                485                 490                 495     


Ala Gly Thr Gly Gly Ala Ala Ala Gly Thr Gly Gly Ala Thr Ala Ala 
            500                 505                 510         


Cys Gly Cys Cys Cys Thr Gly Cys Ala Gly Thr Cys Ala Gly Gly Cys 
        515                 520                 525             


Ala Ala Cys Thr Cys Thr Cys Ala Gly Gly Ala Ala Thr Cys Ala Gly 
    530                 535                 540                 


Thr Cys Ala Cys Cys Gly Ala Gly Cys Ala Gly Gly Ala Cys Thr Cys 
545                 550                 555                 560 


Thr Ala Ala Gly Gly Ala Thr Ala Gly Cys Ala Cys Cys Thr Ala Thr 
                565                 570                 575     


Ala Gly Cys Cys Thr Gly Thr Cys Thr Ala Gly Cys Ala Cys Cys Cys 
            580                 585                 590         


Thr Gly Ala Cys Cys Cys Thr Gly Thr Cys Thr Ala Ala Gly Gly Cys 
        595                 600                 605             


Cys Gly Ala Cys Thr Ala Cys Gly Ala Gly Ala Ala Gly Cys Ala Cys 
    610                 615                 620                 


Ala Ala Gly Gly Thr Cys Thr Ala Cys Gly Cys Cys Thr Gly Cys Gly 
625                 630                 635                 640 


Ala Ala Gly Thr Gly Ala Cys Thr Cys Ala Cys Cys Ala Gly Gly Gly 
                645                 650                 655     


Ala Cys Thr Gly Thr Cys Thr Ala Gly Cys Cys Cys Cys Gly Thr Gly 
            660                 665                 670         


Ala Cys Thr Ala Ala Gly Thr Cys Cys Thr Thr Thr Ala Ala Thr Ala 
        675                 680                 685             


Gly Ala Gly Gly Cys Gly Ala Gly Thr Gly Cys Thr Gly Ala 
    690                 695                 700         


<210>  22
<211>  1407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHO-optimized cDNA sequence coding for chimeric clone 20E5 human 
       IgG1 chain

<400>  22

Ala Thr Gly Gly Ala Gly Thr Gly Gly Thr Cys Ala Gly Gly Cys Gly 
1               5                   10                  15      


Thr Gly Thr Thr Cys Ala Thr Gly Thr Thr Cys Cys Thr Gly Cys Thr 
            20                  25                  30          


Gly Ala Gly Cys Gly Thr Gly Ala Cys Cys Gly Cys Thr Gly Gly Cys 
        35                  40                  45              


Gly Thr Gly Cys Ala Cys Thr Cys Ala Gly Ala Gly Gly Thr Gly Cys 
    50                  55                  60                  


Ala Gly Cys Thr Gly Cys Ala Gly Cys Ala Gly Thr Cys Ala Gly Gly 
65                  70                  75                  80  


Cys Cys Cys Cys Gly Ala Gly Cys Thr Gly Gly Thr Cys Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Cys Gly Cys Thr Ala Gly Cys Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Ala Thr Gly Ala Gly Cys Thr Gly Thr Ala Ala Ala Gly Cys 
        115                 120                 125             


Thr Ala Gly Cys Gly Gly Cys Thr Ala Cys Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Cys Thr Ala Gly Cys Thr Ala Cys Gly Thr Gly Ala Thr Gly Cys 
145                 150                 155                 160 


Ala Cys Thr Gly Gly Gly Thr Cys Ala Ala Gly Cys Ala Gly Ala Ala 
                165                 170                 175     


Gly Cys Cys Cys Gly Gly Thr Cys Ala Gly Gly Gly Cys Cys Thr Gly 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Cys Gly Gly Cys Thr Ala Thr Ala 
        195                 200                 205             


Thr Thr Ala Ala Cys Cys Cys Cys Thr Ala Thr Ala Ala Cys Gly Ala 
    210                 215                 220                 


Cys Gly Gly Cys Ala Cys Thr Ala Ala Gly Thr Ala Thr Ala Ala Cys 
225                 230                 235                 240 


Gly Ala Gly Ala Ala Gly Thr Thr Thr Ala Ala Gly Gly Gly Thr Ala 
                245                 250                 255     


Ala Ala Gly Cys Thr Ala Cys Cys Cys Thr Gly Ala Cys Thr Ala Gly 
            260                 265                 270         


Cys Gly Ala Thr Ala Ala Gly Thr Cys Thr Ala Gly Cys Thr Cys Thr 
        275                 280                 285             


Ala Cys Cys Gly Cys Cys Thr Ala Thr Ala Thr Gly Gly Ala Ala Cys 
    290                 295                 300                 


Thr Gly Thr Cys Thr Ala Gly Thr Cys Thr Gly Ala Cys Thr Ala Gly 
305                 310                 315                 320 


Thr Gly Ala Ala Gly Ala Thr Ala Gly Cys Gly Cys Cys Gly Thr Cys 
                325                 330                 335     


Thr Ala Cys Thr Ala Cys Thr Gly Cys Gly Cys Thr Ala Ala Cys Thr 
            340                 345                 350         


Ala Cys Thr Ala Cys Gly Gly Cys Thr Cys Thr Ala Gly Cys Cys Thr 
        355                 360                 365             


Gly Thr Cys Thr Ala Thr Gly Gly Ala Cys Thr Ala Cys Thr Gly Gly 
    370                 375                 380                 


Gly Gly Thr Cys Ala Gly Gly Gly Cys Ala Cys Thr Ala Gly Cys Gly 
385                 390                 395                 400 


Thr Gly Ala Cys Cys Gly Thr Gly Thr Cys Thr Ala Gly Cys Gly Cys 
                405                 410                 415     


Thr Ala Gly Cys Ala Cys Thr Ala Ala Gly Gly Gly Cys Cys Cys Thr 
            420                 425                 430         


Ala Gly Cys Gly Thr Gly Thr Thr Cys Cys Cys Cys Cys Thr Gly Gly 
        435                 440                 445             


Cys Cys Cys Cys Thr Ala Gly Cys Thr Cys Thr Ala Ala Gly Thr Cys 
    450                 455                 460                 


Thr Ala Cys Thr Ala Gly Cys Gly Gly Cys Gly Gly Cys Ala Cys Cys 
465                 470                 475                 480 


Gly Cys Cys Gly Cys Thr Cys Thr Gly Gly Gly Cys Thr Gly Cys Cys 
                485                 490                 495     


Thr Gly Gly Thr Cys Ala Ala Gly Gly Ala Cys Thr Ala Cys Thr Thr 
            500                 505                 510         


Cys Cys Cys Cys Gly Ala Gly Cys Cys Cys Gly Thr Gly Ala Cys Cys 
        515                 520                 525             


Gly Thr Cys Ala Gly Cys Thr Gly Gly Ala Ala Thr Ala Gly Cys Gly 
    530                 535                 540                 


Gly Cys Gly Cys Thr Cys Thr Gly Ala Cys Thr Ala Gly Cys Gly Gly 
545                 550                 555                 560 


Ala Gly Thr Gly Cys Ala Cys Ala Cys Cys Thr Thr Cys Cys Cys Cys 
                565                 570                 575     


Gly Cys Cys Gly Thr Gly Cys Thr Gly Cys Ala Gly Thr Cys Thr Ala 
            580                 585                 590         


Gly Cys Gly Gly Cys Cys Thr Gly Thr Ala Thr Ala Gly Thr Cys Thr 
        595                 600                 605             


Gly Thr Cys Thr Ala Gly Cys Gly Thr Gly Gly Thr Cys Ala Cys Cys 
    610                 615                 620                 


Gly Thr Gly Cys Cys Thr Ala Gly Thr Thr Cys Thr Ala Gly Cys Cys 
625                 630                 635                 640 


Thr Gly Gly Gly Cys Ala Cys Thr Cys Ala Gly Ala Cys Cys Thr Ala 
                645                 650                 655     


Thr Ala Thr Cys Thr Gly Thr Ala Ala Cys Gly Thr Gly Ala Ala Cys 
            660                 665                 670         


Cys Ala Cys Ala Ala Gly Cys Cys Cys Thr Cys Thr Ala Ala Cys Ala 
        675                 680                 685             


Cys Thr Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Gly Ala Ala 
    690                 695                 700                 


Gly Gly Thr Gly Gly Ala Ala Cys Cys Thr Ala Ala Gly Thr Cys Cys 
705                 710                 715                 720 


Thr Gly Cys Gly Ala Thr Ala Ala Gly Ala Cys Thr Cys Ala Cys Ala 
                725                 730                 735     


Cys Cys Thr Gly Thr Cys Cys Cys Cys Cys Cys Thr Gly Cys Cys Cys 
            740                 745                 750         


Thr Gly Cys Cys Cys Cys Thr Gly Ala Gly Cys Thr Gly Cys Thr Gly 
        755                 760                 765             


Gly Gly Ala Gly Gly Ala Cys Cys Thr Ala Gly Thr Gly Thr Gly Thr 
    770                 775                 780                 


Thr Cys Cys Thr Gly Thr Thr Cys Cys Cys Ala Cys Cys Thr Ala Ala 
785                 790                 795                 800 


Gly Cys Cys Thr Ala Ala Gly Gly Ala Cys Ala Cys Cys Cys Thr Gly 
                805                 810                 815     


Ala Thr Gly Ala Thr Cys Thr Cys Thr Ala Gly Ala Ala Cys Cys Cys 
            820                 825                 830         


Cys Cys Gly Ala Ala Gly Thr Gly Ala Cys Cys Thr Gly Cys Gly Thr 
        835                 840                 845             


Gly Gly Thr Gly Gly Thr Gly Gly Ala Cys Gly Thr Cys Ala Gly Thr 
    850                 855                 860                 


Cys Ala Cys Gly Ala Gly Gly Ala Cys Cys Cys Thr Gly Ala Ala Gly 
865                 870                 875                 880 


Thr Gly Ala Ala Gly Thr Thr Thr Ala Ala Thr Thr Gly Gly Thr Ala 
                885                 890                 895     


Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys Gly Thr Gly Gly Ala Ala 
            900                 905                 910         


Gly Thr Gly Cys Ala Cys Ala Ala Cys Gly Cys Thr Ala Ala Gly Ala 
        915                 920                 925             


Cys Thr Ala Ala Gly Cys Cys Thr Ala Gly Ala Gly Ala Gly Gly Ala 
    930                 935                 940                 


Ala Cys Ala Gly Thr Ala Thr Ala Ala Cys Thr Cys Thr Ala Cys Cys 
945                 950                 955                 960 


Thr Ala Thr Ala Gly Gly Gly Thr Cys Gly Thr Cys Ala Gly Cys Gly 
                965                 970                 975     


Thr Gly Cys Thr Gly Ala Cys Cys Gly Thr Gly Cys Thr Gly Cys Ala 
            980                 985                 990         


Cys Cys Ala Gly Gly Ala Cys Thr  Gly Gly Cys Thr Gly  Ala Ala Cys 
        995                 1000                 1005             


Gly Gly  Thr Ala Ala Ala Gly  Ala Gly Thr Ala Thr  Ala Ala Gly 
    1010                 1015                 1020             


Thr Gly  Thr Ala Ala Ala Gly  Thr Gly Thr Cys Thr  Ala Ala Cys 
    1025                 1030                 1035             


Ala Ala  Gly Gly Cys Cys Cys  Thr Gly Cys Cys Ala  Gly Cys Cys 
    1040                 1045                 1050             


Cys Cys  Thr Ala Thr Cys Gly  Ala Ala Ala Ala Gly  Ala Cys Thr 
    1055                 1060                 1065             


Ala Thr  Cys Thr Cys Thr Ala  Ala Gly Gly Cys Thr  Ala Ala Gly 
    1070                 1075                 1080             


Gly Gly  Thr Cys Ala Gly Cys  Cys Thr Ala Gly Gly  Gly Ala Ala 
    1085                 1090                 1095             


Cys Cys  Thr Cys Ala Gly Gly  Thr Cys Thr Ala Cys  Ala Cys Cys 
    1100                 1105                 1110             


Cys Thr  Gly Cys Cys Cys Cys  Cys Thr Ala Gly Thr  Ala Gly Gly 
    1115                 1120                 1125             


Gly Ala  Cys Gly Ala Gly Cys  Thr Gly Ala Cys Thr  Ala Ala Gly 
    1130                 1135                 1140             


Ala Ala  Thr Cys Ala Gly Gly  Thr Cys Ala Gly Cys  Cys Thr Gly 
    1145                 1150                 1155             


Ala Cys  Thr Thr Gly Thr Cys  Thr Gly Gly Thr Cys  Ala Ala Gly 
    1160                 1165                 1170             


Gly Gly  Cys Thr Thr Cys Thr  Ala Cys Cys Cys Thr  Ala Gly Cys 
    1175                 1180                 1185             


Gly Ala  Thr Ala Thr Cys Gly  Cys Cys Gly Thr Cys  Gly Ala Gly 
    1190                 1195                 1200             


Thr Gly  Gly Gly Ala Gly Thr  Cys Thr Ala Ala Cys  Gly Gly Thr 
    1205                 1210                 1215             


Cys Ala  Gly Cys Cys Cys Gly  Ala Gly Ala Ala Cys  Ala Ala Cys 
    1220                 1225                 1230             


Thr Ala  Thr Ala Ala Gly Ala  Cys Thr Ala Cys Cys  Cys Cys Cys 
    1235                 1240                 1245             


Cys Cys  Thr Gly Thr Gly Cys  Thr Gly Gly Ala Thr  Ala Gly Cys 
    1250                 1255                 1260             


Gly Ala  Cys Gly Gly Thr Ala  Gly Cys Thr Thr Cys  Thr Thr Cys 
    1265                 1270                 1275             


Cys Thr  Gly Thr Ala Cys Thr  Cys Thr Ala Ala Ala  Cys Thr Gly 
    1280                 1285                 1290             


Ala Cys  Cys Gly Thr Gly Gly  Ala Thr Ala Ala Gly  Thr Cys Thr 
    1295                 1300                 1305             


Ala Gly  Gly Thr Gly Gly Cys  Ala Gly Cys Ala Gly  Gly Gly Thr 
    1310                 1315                 1320             


Ala Ala  Cys Gly Thr Gly Thr  Thr Cys Ala Gly Cys  Thr Gly Thr 
    1325                 1330                 1335             


Ala Gly  Cys Gly Thr Gly Ala  Thr Gly Cys Ala Cys  Gly Ala Gly 
    1340                 1345                 1350             


Gly Cys  Cys Cys Thr Gly Cys  Ala Cys Ala Ala Thr  Cys Ala Cys 
    1355                 1360                 1365             


Thr Ala  Cys Ala Cys Thr Cys  Ala Gly Ala Ala Gly  Thr Cys Ala 
    1370                 1375                 1380             


Cys Thr  Gly Ala Gly Cys Cys  Thr Gly Ala Gly Cys  Cys Cys Cys 
    1385                 1390                 1395             


Gly Gly  Thr Ala Ala Gly Thr  Gly Ala 
    1400                 1405         


<210>  23
<211>  1404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHO-optimized cDNA sequence coding for chimeric clone 12H3 human 
       IgG4 chain

<400>  23

Ala Thr Gly Gly Ala Gly Thr Gly Gly Thr Cys Thr Gly Gly Thr Gly 
1               5                   10                  15      


Thr Cys Thr Thr Thr Ala Thr Gly Thr Thr Cys Cys Thr Gly Cys Thr 
            20                  25                  30          


Gly Thr Cys Cys Gly Thr Gly Ala Cys Cys Gly Cys Gly Gly Gly Thr 
        35                  40                  45              


Gly Thr Cys Cys Ala Cys Ala Gly Cys Gly Ala Gly Gly Thr Gly Cys 
    50                  55                  60                  


Ala Gly Cys Thr Gly Cys Ala Gly Cys Ala Gly Thr Cys Cys Gly Gly 
65                  70                  75                  80  


Cys Cys Cys Thr Gly Ala Gly Cys Thr Gly Gly Thr Gly Ala Ala Ala 
                85                  90                  95      


Cys Cys Thr Gly Gly Cys Gly Cys Cys Thr Cys Cys Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Ala Thr Cys Thr Cys Cys Thr Gly Cys Ala Ala Gly Ala Cys 
        115                 120                 125             


Cys Thr Cys Cys Gly Gly Cys Thr Ala Cys Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Ala Gly Gly Ala Cys Thr Ala Cys Ala Cys Ala Ala Thr Gly Cys 
145                 150                 155                 160 


Ala Cys Thr Gly Gly Gly Thr Gly Ala Ala Ala Cys Ala Gly Thr Cys 
                165                 170                 175     


Cys Cys Ala Cys Gly Gly Cys Ala Ala Gly Thr Cys Cys Thr Thr Gly 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Cys Gly Gly Cys Gly Gly Ala Ala 
        195                 200                 205             


Thr Cys Thr Ala Cys Cys Cys Cys Ala Ala Cys Ala Ala Cys Gly Gly 
    210                 215                 220                 


Cys Gly Gly Cys Thr Cys Cys Ala Cys Cys Thr Ala Cys Ala Ala Cys 
225                 230                 235                 240 


Cys Ala Gly Ala Ala Cys Thr Thr Cys Ala Ala Gly Gly Ala Cys Ala 
                245                 250                 255     


Ala Gly Gly Cys Cys Ala Cys Cys Cys Thr Gly Ala Cys Cys Gly Thr 
            260                 265                 270         


Gly Gly Ala Cys Ala Ala Gly Thr Cys Cys Thr Cys Cys Thr Cys Cys 
        275                 280                 285             


Ala Cys Cys Gly Cys Cys Thr Ala Thr Ala Thr Gly Gly Ala Ala Thr 
    290                 295                 300                 


Thr Thr Cys Gly Gly Thr Cys Cys Cys Thr Gly Ala Cys Cys Thr Cys 
305                 310                 315                 320 


Cys Gly Ala Gly Gly Ala Cys Thr Cys Cys Gly Cys Cys Gly Thr Gly 
                325                 330                 335     


Thr Ala Cys Thr Ala Cys Thr Gly Cys Gly Cys Cys Cys Gly Gly Ala 
            340                 345                 350         


Thr Gly Gly Gly Cys Thr Ala Cys Cys Ala Cys Gly Gly Cys Cys Cys 
        355                 360                 365             


Cys Cys Ala Cys Cys Thr Gly Gly Ala Thr Thr Thr Cys Gly Ala Cys 
    370                 375                 380                 


Gly Thr Gly Thr Gly Gly Gly Gly Cys Gly Cys Thr Gly Gly Cys Ala 
385                 390                 395                 400 


Cys Cys Ala Cys Cys Gly Thr Gly Ala Cys Cys Gly Thr Gly Thr Cys 
                405                 410                 415     


Thr Cys Cys Ala Gly Cys Thr Ala Gly Cys Ala Cys Cys Ala Ala Gly 
            420                 425                 430         


Gly Gly Cys Cys Cys Cys Thr Cys Cys Gly Thr Gly Thr Thr Cys Cys 
        435                 440                 445             


Cys Thr Cys Thr Gly Gly Cys Cys Cys Cys Thr Thr Gly Cys Thr Cys 
    450                 455                 460                 


Cys Cys Gly Gly Thr Cys Cys Ala Cys Cys Thr Cys Cys Gly Ala Gly 
465                 470                 475                 480 


Thr Cys Thr Ala Cys Cys Gly Cys Cys Gly Cys Thr Cys Thr Gly Gly 
                485                 490                 495     


Gly Cys Thr Gly Cys Cys Thr Gly Gly Thr Gly Ala Ala Ala Gly Ala 
            500                 505                 510         


Cys Thr Ala Cys Thr Thr Cys Cys Cys Cys Gly Ala Gly Cys Cys Cys 
        515                 520                 525             


Gly Thr Gly Ala Cys Ala Gly Thr Gly Thr Cys Cys Thr Gly Gly Ala 
    530                 535                 540                 


Ala Cys Thr Cys Thr Gly Gly Cys Gly Cys Cys Cys Thr Gly Ala Cys 
545                 550                 555                 560 


Cys Ala Gly Cys Gly Gly Cys Gly Thr Gly Cys Ala Cys Ala Cys Cys 
                565                 570                 575     


Thr Thr Cys Cys Cys Thr Gly Cys Cys Gly Thr Gly Cys Thr Gly Cys 
            580                 585                 590         


Ala Gly Thr Cys Cys Thr Cys Cys Gly Gly Cys Cys Thr Gly Thr Ala 
        595                 600                 605             


Cys Thr Cys Cys Cys Thr Gly Thr Cys Cys Thr Cys Cys Gly Thr Gly 
    610                 615                 620                 


Gly Thr Gly Ala Cys Ala Gly Thr Gly Cys Cys Cys Thr Cys Cys Thr 
625                 630                 635                 640 


Cys Cys Ala Gly Cys Cys Thr Gly Gly Gly Cys Ala Cys Cys Ala Ala 
                645                 650                 655     


Gly Ala Cys Cys Thr Ala Cys Ala Cys Cys Thr Gly Thr Ala Ala Cys 
            660                 665                 670         


Gly Thr Gly Gly Ala Cys Cys Ala Cys Ala Ala Gly Cys Cys Cys Thr 
        675                 680                 685             


Cys Cys Ala Ala Cys Ala Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala 
    690                 695                 700                 


Cys Ala Ala Gly Cys Gly Gly Gly Thr Gly Gly Ala Ala Thr Cys Thr 
705                 710                 715                 720 


Ala Ala Gly Thr Ala Cys Gly Gly Cys Cys Cys Thr Cys Cys Cys Thr 
                725                 730                 735     


Gly Cys Cys Cys Ala Cys Cys Thr Thr Gly Cys Cys Cys Thr Gly Cys 
            740                 745                 750         


Cys Cys Cys Thr Gly Ala Ala Thr Thr Thr Cys Thr Gly Gly Gly Cys 
        755                 760                 765             


Gly Gly Ala Cys Cys Thr Thr Cys Cys Gly Thr Gly Thr Thr Cys Cys 
    770                 775                 780                 


Thr Gly Thr Thr Cys Cys Cys Cys Cys Cys Ala Ala Ala Gly Cys Cys 
785                 790                 795                 800 


Cys Ala Ala Gly Gly Ala Cys Ala Cys Cys Cys Thr Gly Ala Thr Gly 
                805                 810                 815     


Ala Thr Cys Thr Cys Cys Cys Gly Gly Ala Cys Cys Cys Cys Cys Gly 
            820                 825                 830         


Ala Ala Gly Thr Gly Ala Cys Cys Thr Gly Cys Gly Thr Gly Gly Thr 
        835                 840                 845             


Gly Gly Thr Gly Gly Ala Cys Gly Thr Gly Thr Cys Cys Cys Ala Ala 
    850                 855                 860                 


Gly Ala Ala Gly Ala Thr Cys Cys Cys Gly Ala Gly Gly Thr Cys Cys 
865                 870                 875                 880 


Ala Gly Thr Thr Cys Ala Ala Thr Thr Gly Gly Thr Ala Cys Gly Thr 
                885                 890                 895     


Gly Gly Ala Cys Gly Gly Cys Gly Thr Gly Gly Ala Ala Gly Thr Gly 
            900                 905                 910         


Cys Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Gly Ala Cys Cys Ala 
        915                 920                 925             


Ala Gly Cys Cys Cys Ala Gly Ala Gly Ala Gly Gly Ala Ala Cys Ala 
    930                 935                 940                 


Gly Thr Thr Cys Ala Ala Cys Thr Cys Cys Ala Cys Cys Thr Ala Cys 
945                 950                 955                 960 


Cys Gly Gly Gly Thr Gly Gly Thr Gly Thr Cys Cys Gly Thr Gly Cys 
                965                 970                 975     


Thr Gly Ala Cys Cys Gly Thr Gly Cys Thr Gly Cys Ala Cys Cys Ala 
            980                 985                 990         


Gly Gly Ala Cys Thr Gly Gly Cys  Thr Gly Ala Ala Cys  Gly Gly Cys 
        995                 1000                 1005             


Ala Ala  Ala Gly Ala Gly Thr  Ala Cys Ala Ala Gly  Thr Gly Cys 
    1010                 1015                 1020             


Ala Ala  Gly Gly Thr Cys Thr  Cys Cys Ala Ala Cys  Ala Ala Gly 
    1025                 1030                 1035             


Gly Gly  Cys Cys Thr Gly Cys  Cys Cys Ala Gly Cys  Thr Cys Thr 
    1040                 1045                 1050             


Ala Thr  Cys Gly Ala Ala Ala  Ala Gly Ala Cys Ala  Ala Thr Cys 
    1055                 1060                 1065             


Thr Cys  Cys Ala Ala Gly Gly  Cys Cys Ala Ala Gly  Gly Gly Cys 
    1070                 1075                 1080             


Cys Ala  Gly Cys Cys Cys Cys  Gly Cys Gly Ala Gly  Cys Cys Cys 
    1085                 1090                 1095             


Cys Ala  Gly Gly Thr Gly Thr  Ala Cys Ala Cys Cys  Cys Thr Gly 
    1100                 1105                 1110             


Cys Cys  Thr Cys Cys Cys Ala  Gly Cys Cys Ala Ala  Gly Ala Ala 
    1115                 1120                 1125             


Gly Ala  Gly Ala Thr Gly Ala  Cys Cys Ala Ala Gly  Ala Ala Cys 
    1130                 1135                 1140             


Cys Ala  Gly Gly Thr Gly Thr  Cys Cys Cys Thr Gly  Ala Cys Thr 
    1145                 1150                 1155             


Thr Gly  Thr Cys Thr Gly Gly  Thr Gly Ala Ala Ala  Gly Gly Cys 
    1160                 1165                 1170             


Thr Thr  Cys Thr Ala Cys Cys  Cys Cys Thr Cys Cys  Gly Ala Thr 
    1175                 1180                 1185             


Ala Thr  Cys Gly Cys Cys Gly  Thr Cys Gly Ala Gly  Thr Gly Gly 
    1190                 1195                 1200             


Gly Ala  Gly Thr Cys Cys Ala  Ala Cys Gly Gly Cys  Cys Ala Gly 
    1205                 1210                 1215             


Cys Cys  Cys Gly Ala Gly Ala  Ala Cys Ala Ala Cys  Thr Ala Cys 
    1220                 1225                 1230             


Ala Ala  Gly Ala Cys Cys Ala  Cys Cys Cys Cys Cys  Cys Cys Thr 
    1235                 1240                 1245             


Gly Thr  Gly Cys Thr Gly Gly  Ala Cys Thr Cys Cys  Gly Ala Cys 
    1250                 1255                 1260             


Gly Gly  Cys Thr Cys Cys Thr  Thr Cys Thr Thr Cys  Cys Thr Gly 
    1265                 1270                 1275             


Thr Ala  Cys Thr Cys Thr Cys  Gly Gly Cys Thr Gly  Ala Cys Ala 
    1280                 1285                 1290             


Gly Thr  Gly Gly Ala Thr Ala  Ala Gly Thr Cys Cys  Cys Gly Gly 
    1295                 1300                 1305             


Thr Gly  Gly Cys Ala Ala Gly  Ala Ala Gly Gly Cys  Ala Ala Cys 
    1310                 1315                 1320             


Gly Thr  Cys Thr Thr Cys Thr  Cys Cys Thr Gly Cys  Thr Cys Cys 
    1325                 1330                 1335             


Gly Thr  Gly Ala Thr Gly Cys  Ala Cys Gly Ala Gly  Gly Cys Cys 
    1340                 1345                 1350             


Cys Thr  Gly Cys Ala Cys Ala  Ala Cys Cys Ala Cys  Thr Ala Cys 
    1355                 1360                 1365             


Ala Cys  Cys Cys Ala Gly Ala  Ala Gly Thr Cys Cys  Cys Thr Gly 
    1370                 1375                 1380             


Thr Cys  Cys Cys Thr Gly Ala  Gly Cys Cys Thr Gly  Gly Gly Cys 
    1385                 1390                 1395             


Ala Ala  Gly Thr Ala Gly 
    1400                 


<210>  24
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHO-optimized cDNA sequence coding for chimeric clone 12H3 human 
       kappa chain

<400>  24

Ala Thr Gly Gly Ala Gly Thr Gly Gly Thr Cys Cys Gly Gly Thr Gly 
1               5                   10                  15      


Thr Cys Thr Thr Thr Ala Thr Gly Thr Thr Cys Cys Thr Gly Cys Thr 
            20                  25                  30          


Gly Thr Cys Cys Gly Thr Gly Ala Cys Cys Gly Cys Thr Gly Gly Cys 
        35                  40                  45              


Gly Thr Gly Cys Ala Cys Thr Cys Cys Gly Ala Thr Ala Thr Cys Gly 
    50                  55                  60                  


Thr Gly Ala Thr Gly Ala Cys Cys Cys Ala Gly Thr Cys Cys Cys Ala 
65                  70                  75                  80  


Cys Ala Ala Gly Thr Thr Thr Ala Thr Gly Thr Cys Cys Ala Cys Cys 
                85                  90                  95      


Thr Cys Cys Cys Thr Gly Gly Gly Cys Gly Ala Cys Ala Gly Ala Gly 
            100                 105                 110         


Thr Cys Thr Cys Thr Ala Thr Thr Ala Cys Cys Thr Gly Cys Ala Ala 
        115                 120                 125             


Gly Gly Cys Cys Thr Cys Cys Cys Ala Gly Gly Ala Cys Gly Thr Gly 
    130                 135                 140                 


Gly Gly Cys Gly Cys Thr Gly Cys Cys Gly Thr Gly Gly Cys Cys Thr 
145                 150                 155                 160 


Gly Gly Thr Ala Thr Cys Ala Gly Cys Ala Gly Ala Ala Gly Cys Cys 
                165                 170                 175     


Cys Gly Gly Cys Cys Ala Gly Thr Cys Cys Cys Cys Cys Ala Ala Gly 
            180                 185                 190         


Cys Thr Gly Cys Thr Gly Ala Thr Cys Thr Ala Cys Thr Gly Gly Gly 
        195                 200                 205             


Cys Cys Thr Cys Cys Ala Cys Cys Ala Gly Ala Cys Ala Cys Ala Cys 
    210                 215                 220                 


Cys Gly Gly Cys Gly Thr Gly Cys Cys Cys Gly Ala Cys Ala Gly Ala 
225                 230                 235                 240 


Thr Thr Cys Ala Cys Cys Gly Gly Cys Gly Gly Ala Gly Gly Cys Thr 
                245                 250                 255     


Cys Thr Gly Gly Cys Ala Cys Cys Gly Ala Cys Thr Thr Cys Ala Cys 
            260                 265                 270         


Cys Cys Thr Gly Ala Cys Ala Ala Thr Cys Thr Cys Cys Ala Ala Cys 
        275                 280                 285             


Gly Thr Gly Cys Ala Gly Thr Cys Cys Gly Ala Gly Gly Ala Cys Cys 
    290                 295                 300                 


Thr Gly Ala Cys Cys Gly Ala Cys Thr Ala Cys Thr Thr Cys Thr Gly 
305                 310                 315                 320 


Cys Cys Ala Gly Cys Ala Gly Thr Ala Thr Ala Thr Cys Ala Ala Cys 
                325                 330                 335     


Thr Ala Cys Cys Cys Cys Cys Thr Gly Ala Cys Cys Thr Thr Cys Gly 
            340                 345                 350         


Gly Cys Gly Gly Ala Gly Gly Cys Ala Cys Cys Ala Ala Gly Cys Thr 
        355                 360                 365             


Gly Gly Ala Ala Ala Thr Cys Ala Ala Gly Cys Gly Gly Ala Cys Cys 
    370                 375                 380                 


Gly Thr Gly Gly Cys Cys Gly Cys Thr Cys Cys Cys Thr Cys Cys Gly 
385                 390                 395                 400 


Thr Gly Thr Thr Thr Ala Thr Cys Thr Thr Cys Cys Cys Ala Cys Cys 
                405                 410                 415     


Cys Thr Cys Cys Gly Ala Cys Gly Ala Gly Cys Ala Gly Cys Thr Gly 
            420                 425                 430         


Ala Ala Gly Thr Cys Cys Gly Gly Cys Ala Cys Cys Gly Cys Cys Thr 
        435                 440                 445             


Cys Cys Gly Thr Gly Gly Thr Cys Thr Gly Cys Cys Thr Gly Cys Thr 
    450                 455                 460                 


Gly Ala Ala Cys Ala Ala Cys Thr Thr Cys Thr Ala Cys Cys Cys Cys 
465                 470                 475                 480 


Cys Gly Cys Gly Ala Gly Gly Cys Cys Ala Ala Gly Gly Thr Gly Cys 
                485                 490                 495     


Ala Gly Thr Gly Gly Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala 
            500                 505                 510         


Cys Gly Cys Cys Cys Thr Gly Cys Ala Gly Thr Cys Cys Gly Gly Cys 
        515                 520                 525             


Ala Ala Cys Thr Cys Cys Cys Ala Ala Gly Ala Ala Thr Cys Cys Gly 
    530                 535                 540                 


Thr Gly Ala Cys Cys Gly Ala Gly Cys Ala Gly Gly Ala Cys Thr Cys 
545                 550                 555                 560 


Cys Ala Ala Gly Gly Ala Cys Ala Gly Cys Ala Cys Cys Thr Ala Cys 
                565                 570                 575     


Thr Cys Cys Cys Thr Gly Thr Cys Cys Thr Cys Cys Ala Cys Cys Cys 
            580                 585                 590         


Thr Gly Ala Cys Cys Cys Thr Gly Thr Cys Cys Ala Ala Gly Gly Cys 
        595                 600                 605             


Cys Gly Ala Cys Thr Ala Cys Gly Ala Gly Ala Ala Gly Cys Ala Cys 
    610                 615                 620                 


Ala Ala Gly Gly Thr Gly Thr Ala Cys Gly Cys Cys Thr Gly Cys Gly 
625                 630                 635                 640 


Ala Ala Gly Thr Gly Ala Cys Cys Cys Ala Cys Cys Ala Gly Gly Gly 
                645                 650                 655     


Cys Cys Thr Gly Thr Cys Cys Ala Gly Cys Cys Cys Cys Gly Thr Gly 
            660                 665                 670         


Ala Cys Cys Ala Ala Gly Thr Cys Cys Thr Thr Cys Ala Ala Cys Cys 
        675                 680                 685             


Gly Gly Gly Gly Cys Gly Ala Gly Thr Gly Cys Thr Ala Ala 
    690                 695                 700         


<210>  25
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of chimeric clone 20E5 human IgG4 chain

<400>  25

Met Glu Trp Ser Gly Val Phe Met Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Asn Tyr Tyr Gly Ser Ser Leu Ser Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
225                 230                 235                 240 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455                 460                 


Lys 
465 


<210>  26
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of chimeric clone 20E5 human kappa chain

<400>  26

Met Glu Trp Ser Gly Val Phe Met Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn 
                85                  90                  95      


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  27
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of chimeric clone 20E5 human IgG1 chain

<400>  27

Met Glu Trp Ser Gly Val Phe Met Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Asn Tyr Tyr Gly Ser Ser Leu Ser Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  28
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of chimeric clone 12H3 human IgG4 chain

<400>  28

Met Glu Trp Ser Gly Val Phe Met Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
        35                  40                  45              


Lys Asp Tyr Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Gly Ile Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn 
65                  70                  75                  80  


Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Met Gly Tyr His Gly Pro His Leu Asp Phe Asp 
        115                 120                 125             


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Pro Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
225                 230                 235                 240 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Leu Gly Lys 
465         


<210>  29
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of chimeric clone 12H3 human kappa chain

<400>  29

Met Glu Trp Ser Gly Val Phe Met Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr 
            20                  25                  30          


Ser Leu Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val 
        35                  40                  45              


Gly Ala Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg 
65                  70                  75                  80  


Phe Thr Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn 
                85                  90                  95      


Val Gln Ser Glu Asp Leu Thr Asp Tyr Phe Cys Gln Gln Tyr Ile Asn 
            100                 105                 110         


Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  30
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of human CD134_CRD2 (aa 1-28 >< 66-277)

<220>
<221>   SIGNAL
<222>   (1)...(28)

<220>
<221>   TRANSMEM
<222>   (178)...(198)

<400>  30

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Pro Cys Gly Pro 
            20                  25                  30          


Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro Cys Lys Pro Cys Thr 
        35                  40                  45              


Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys Gln Leu Cys Thr Ala 
    50                  55                  60                  


Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly Thr Gln Pro Leu Asp 
65                  70                  75                  80  


Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys Pro Pro Gly His Phe 
                85                  90                  95      


Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp Thr Asn Cys Thr Leu 
            100                 105                 110         


Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn Ser Ser Asp Ala Ile 
        115                 120                 125             


Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro Gln Glu Thr Gln Gly 
    130                 135                 140                 


Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr Glu Ala Trp Pro Arg 
145                 150                 155                 160 


Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu Val Pro Gly Gly Arg 
                165                 170                 175     


Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly 
            180                 185                 190         


Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg 
        195                 200                 205             


Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr 
    210                 215                 220                 


Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
225                 230                 235                 240 


<210>  31
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of human CD134_CRD3 (aa 1-28 >< 108-277)

<220>
<221>   SIGNAL
<222>   (1)...(28)

<220>
<221>   TRANSMEM
<222>   (136)...(156)

<400>  31

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Arg Cys Arg Ala 
            20                  25                  30          


Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro 
        35                  40                  45              


Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro 
    50                  55                  60                  


Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser 
65                  70                  75                  80  


Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln 
                85                  90                  95      


Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro 
            100                 105                 110         


Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val 
        115                 120                 125             


Glu Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu 
    130                 135                 140                 


Val Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu 
145                 150                 155                 160 


Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly 
                165                 170                 175     


Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His 
            180                 185                 190         


Ser Thr Leu Ala Lys Ile 
        195             


<210>  32
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of human CD134_CRD4 (aa 1-28 >< 127-277)

<220>
<221>   SIGNAL
<222>   (1)...(28)

<220>
<221>   TRANSMEM
<222>   (117)...(137)

<400>  32

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Pro Cys Pro Pro 
            20                  25                  30          


Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp Thr Asn 
        35                  40                  45              


Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn Ser Ser 
    50                  55                  60                  


Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro Gln Glu 
65                  70                  75                  80  


Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr Glu Ala 
                85                  90                  95      


Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu Val Pro 
            100                 105                 110         


Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly 
        115                 120                 125             


Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg 
    130                 135                 140                 


Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser 
145                 150                 155                 160 


Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu 
                165                 170                 175     


Ala Lys Ile 
            


<210>  33
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of human CD134_CRD4 truncated (aa 1-28 >< 
       147-277)

<220>
<221>   SIGNAL
<222>   (1)...(28)

<220>
<221>   TRANSMEM
<222>   (97)...(117)

<400>  33

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Cys Thr Leu Ala 
            20                  25                  30          


Gly Lys His Thr Leu Gln Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys 
        35                  40                  45              


Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro 
    50                  55                  60                  


Pro Ala Arg Pro Ile Thr Val Gln Pro Thr Glu Ala Trp Pro Arg Thr 
65                  70                  75                  80  


Ser Gln Gly Pro Ser Thr Arg Pro Val Glu Val Pro Gly Gly Arg Ala 
                85                  90                  95      


Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
            100                 105                 110         


Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu 
        115                 120                 125             


Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro 
    130                 135                 140                 


Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
145                 150                 155                 


<210>  34
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  34

Arg Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val 
1               5                   10                  15      


Asp Cys Ala 
            


<210>  35
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  35

Arg Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val 
1               5                   10                  15      


Asp Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln 
            20                  25                  30          


Ala Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu 
        35                  40                  45              


Gln Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro 
    50                  55                  60                  


Pro Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile 
65                  70                  75                  80  


Thr Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser 
                85                  90                  95      


Thr Arg Pro Val Glu Val Pro Gly Gly Arg Ala 
            100                 105         


<210>  36
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  36

Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn Ser Ser 
1               5                   10                  15      


Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro Gln Glu 
            20                  25                  30          


Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr Glu Ala 
        35                  40                  45              


Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu Val Pro 
    50                  55                  60                  


Gly Gly Arg Ala 
65              


<210>  37
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  37

Thr Tyr Ser Ser Pro Glu Asp Gly Ile His Glu Leu Phe Pro Ala Pro 
1               5                   10                  15      


Asp Gly Glu Glu Asp Thr Ala Glu Leu Gln Gly Gly Cys 
            20                  25                  


<210>  38
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  38

Arg Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val 
1               5                   10                  15      


Asp Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln 
            20                  25                  30          


Ala Cys Lys Pro Trp Thr Asn 
        35                  


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mkappa antisense primer (primer no: 201)

<400>  39
gacagttggt gcagcatcag                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mkappa antisense primer (primer no: 266)

<400>  40
cactggatgg tgggaagatg                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mlgG1 antisense primer (primer no: 203)

<400>  41
ggccagtgga tagacagatg                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mlgG1 antisense primer (primer no: 204)

<400>  42
tggacaggga tccagagttc                                                   20


<210>  43
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  20E5HC sense primer (primer no: 259)

<400>  43
gcgaagtaca aytncarcar wsngg                                             25


<210>  44
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  20E5HC sense primer (primer no: 260)


<400>  44
gcgtacaatt acarcarwsn ggncc                                             25


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  20E5LC sense primer (primer no: 265)


<400>  45
gcgatataca ratgacncar ac                                                22


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mlgG1 antisense primer (primer no: 416)

<400>  46
cagtggatag acagatgggg g                                                 21


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mkappa antisense primer (primer no: 394)

<400>  47
actggatggt gggaagatgg                                                   20


<210>  48
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal peptide sense primer (primer no: 405)

<400>  48
atgggatgga gctrtatcat sytctt                                            26


<210>  49
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal peptide sense primer (primer no: 410)

<400>  49
atggratgga gckgggtctt tmtctt                                            26


<210>  50
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal peptide sense primer (primer no: 389)

<400>  50
atgggcwtca aagatggagt caca                                              24


<210>  51
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD134 leader sense primer (primer no: 362)

<400>  51
ctcggatccg ccaccatgtg cgtg                                              24


<210>  52
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRD2 sense primer (primer no: 364)

<400>  52
actgtcactg gaccctgcgg tccc                                              24


<210>  53
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRD2 antisense primer (primer no: 365)

<400>  53
gggaccgcag ggtccagtga cagt                                              24


<210>  54
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRD3 sense primer (primer no: 366)

<400>  54
actgtcactg gaaggtgcag ggct                                              24


<210>  55
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD134 end primer (primer no: 363)

<400>  55
agaattctta ttagatcttg gcca                                              24


<210>  56
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRD3 antisense primer (primer no: 367)

<400>  56
agccctgcac cttccagtga cagt                                              24


<210>  57
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRD4 sense primer (primer no: 368)

<400>  57
actgtcactg gaccctgccc ccct                                              24


<210>  58
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRD4 antisense primer (primer no: 369)

<400>  58
aggggggcag ggtccagtga cagt                                              24


<210>  59
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRD4 truncated sense primer (primer no: 370)

<400>  59
actgtcactg gatgcaccct ggct                                              24


<210>  60
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRD4 truncated antisense primer (primer no: 371)

<400>  60
agccagggtg catccagtga cagt                                              24


<210>  61
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal amino acid sequence of clone 20E5 light chain

<400>  61

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
1               5                   10      

