
                                SEQUENCE LISTING

<110> University of Massachusetts

<120> SRPX FOR TREATMENT OF CANCER
  

<130> 07917-0348WO1

<150> US 61/534,655       
<151> 2011-09-14  

<160> 8

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 429
<212> PRT
<213> Homo sapien

<400> 1
Asp Ser Pro Leu Glu Asp Asp Glu Val Gly Tyr Ser His Pro Arg Tyr
 1               5                  10                  15      
Lys Asp Thr Pro Trp Cys Ser Pro Ile Lys Val Lys Tyr Gly Asp Val
            20                  25                  30          
Tyr Cys Arg Ala Pro Gln Gly Gly Tyr Tyr Lys Thr Ala Leu Gly Thr
        35                  40                  45              
Arg Cys Asp Ile Arg Cys Gln Lys Gly Tyr Glu Leu His Gly Ser Ser
    50                  55                  60                  
Leu Leu Ile Cys Gln Ser Asn Lys Arg Trp Ser Asp Lys Val Ile Cys
65                  70                  75                  80  
Lys Gln Lys Arg Cys Pro Thr Leu Ala Met Pro Ala Asn Gly Gly Phe
                85                  90                  95      
Lys Cys Val Asp Gly Ala Tyr Phe Asn Ser Arg Cys Glu Tyr Tyr Cys
            100                 105                 110         
Ser Pro Gly Tyr Thr Leu Lys Gly Glu Arg Thr Val Thr Cys Met Asp
        115                 120                 125             
Asn Lys Ala Trp Ser Gly Arg Pro Ala Ser Cys Val Asp Met Glu Pro
    130                 135                 140                 
Pro Arg Ile Lys Cys Pro Ser Val Lys Glu Arg Ile Ala Glu Pro Asn
145                 150                 155                 160 
Lys Leu Thr Val Arg Val Ser Trp Glu Thr Pro Glu Gly Arg Asp Thr
                165                 170                 175     
Ala Asp Gly Ile Leu Thr Asp Val Ile Leu Lys Gly Leu Pro Pro Gly
            180                 185                 190         
Ser Asn Phe Pro Glu Gly Asp His Lys Ile Gln Tyr Thr Val Tyr Asp
        195                 200                 205             
Arg Ala Glu Asn Lys Gly Thr Cys Lys Phe Arg Val Lys Val Arg Val
    210                 215                 220                 
Lys Arg Cys Gly Lys Leu Asn Ala Pro Glu Asn Gly Tyr Met Lys Cys
225                 230                 235                 240 
Ser Ser Asp Gly Asp Asn Tyr Gly Ala Thr Cys Glu Phe Ser Cys Ile
                245                 250                 255     
Gly Gly Tyr Glu Leu Gln Gly Ser Pro Ala Arg Val Cys Gln Ser Asn
            260                 265                 270         
Leu Ala Trp Ser Gly Thr Glu Pro Thr Cys Ala Ala Met Asn Val Asn
        275                 280                 285             
Val Gly Val Arg Thr Ala Ala Ala Leu Leu Asp Gln Phe Tyr Glu Lys
    290                 295                 300                 
Arg Arg Leu Leu Ile Val Ser Thr Pro Thr Ala Arg Asn Leu Leu Tyr
305                 310                 315                 320 
Arg Leu Gln Leu Gly Met Leu Gln Gln Ala Gln Cys Gly Leu Asp Leu
                325                 330                 335     
Arg His Ile Thr Val Val Glu Leu Val Gly Val Phe Pro Thr Leu Ile
            340                 345                 350         
Gly Arg Ile Gly Ala Lys Ile Met Pro Pro Ala Leu Ala Leu Gln Leu
        355                 360                 365             
Arg Leu Leu Leu Arg Ile Pro Leu Tyr Ser Phe Ser Met Val Leu Val
    370                 375                 380                 
Asp Lys His Gly Met Asp Lys Glu Arg Tyr Val Ser Leu Val Met Pro
385                 390                 395                 400 
Val Ala Leu Phe Asn Leu Ile Asp Thr Phe Pro Leu Arg Lys Glu Glu
                405                 410                 415     
Met Val Leu Gln Ala Glu Met Ser Gln Thr Cys Asn Thr
            420                 425                 


<210> 2
<211> 464
<212> PRT
<213> Homo sapien

<400> 2
Met Gly Ser Pro Ala His Arg Pro Ala Leu Leu Leu Leu Leu Pro Pro
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Leu Arg Val Pro Pro Ser Arg Ser Phe Pro
            20                  25                  30          
Gly Ser Gly Asp Ser Pro Leu Glu Asp Asp Glu Val Gly Tyr Ser His
        35                  40                  45              
Pro Arg Tyr Lys Asp Thr Pro Trp Cys Ser Pro Ile Lys Val Lys Tyr
    50                  55                  60                  
Gly Asp Val Tyr Cys Arg Ala Pro Gln Gly Gly Tyr Tyr Lys Thr Ala
65                  70                  75                  80  
Leu Gly Thr Arg Cys Asp Ile Arg Cys Gln Lys Gly Tyr Glu Leu His
                85                  90                  95      
Gly Ser Ser Leu Leu Ile Cys Gln Ser Asn Lys Arg Trp Ser Asp Lys
            100                 105                 110         
Val Ile Cys Lys Gln Lys Arg Cys Pro Thr Leu Ala Met Pro Ala Asn
        115                 120                 125             
Gly Gly Phe Lys Cys Val Asp Gly Ala Tyr Phe Asn Ser Arg Cys Glu
    130                 135                 140                 
Tyr Tyr Cys Ser Pro Gly Tyr Thr Leu Lys Gly Glu Arg Thr Val Thr
145                 150                 155                 160 
Cys Met Asp Asn Lys Ala Trp Ser Gly Arg Pro Ala Ser Cys Val Asp
                165                 170                 175     
Met Glu Pro Pro Arg Ile Lys Cys Pro Ser Val Lys Glu Arg Ile Ala
            180                 185                 190         
Glu Pro Asn Lys Leu Thr Val Arg Val Ser Trp Glu Thr Pro Glu Gly
        195                 200                 205             
Arg Asp Thr Ala Asp Gly Ile Leu Thr Asp Val Ile Leu Lys Gly Leu
    210                 215                 220                 
Pro Pro Gly Ser Asn Phe Pro Glu Gly Asp His Lys Ile Gln Tyr Thr
225                 230                 235                 240 
Val Tyr Asp Arg Ala Glu Asn Lys Gly Thr Cys Lys Phe Arg Val Lys
                245                 250                 255     
Val Arg Val Lys Arg Cys Gly Lys Leu Asn Ala Pro Glu Asn Gly Tyr
            260                 265                 270         
Met Lys Cys Ser Ser Asp Gly Asp Asn Tyr Gly Ala Thr Cys Glu Phe
        275                 280                 285             
Ser Cys Ile Gly Gly Tyr Glu Leu Gln Gly Ser Pro Ala Arg Val Cys
    290                 295                 300                 
Gln Ser Asn Leu Ala Trp Ser Gly Thr Glu Pro Thr Cys Ala Ala Met
305                 310                 315                 320 
Asn Val Asn Val Gly Val Arg Thr Ala Ala Ala Leu Leu Asp Gln Phe
                325                 330                 335     
Tyr Glu Lys Arg Arg Leu Leu Ile Val Ser Thr Pro Thr Ala Arg Asn
            340                 345                 350         
Leu Leu Tyr Arg Leu Gln Leu Gly Met Leu Gln Gln Ala Gln Cys Gly
        355                 360                 365             
Leu Asp Leu Arg His Ile Thr Val Val Glu Leu Val Gly Val Phe Pro
    370                 375                 380                 
Thr Leu Ile Gly Arg Ile Gly Ala Lys Ile Met Pro Pro Ala Leu Ala
385                 390                 395                 400 
Leu Gln Leu Arg Leu Leu Leu Arg Ile Pro Leu Tyr Ser Phe Ser Met
                405                 410                 415     
Val Leu Val Asp Lys His Gly Met Asp Lys Glu Arg Tyr Val Ser Leu
            420                 425                 430         
Val Met Pro Val Ala Leu Phe Asn Leu Ile Asp Thr Phe Pro Leu Arg
        435                 440                 445             
Lys Glu Glu Met Val Leu Gln Ala Glu Met Ser Gln Thr Cys Asn Thr
    450                 455                 460                 


<210> 3
<211> 2962
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetically-generated vector

<400> 3
attaggctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg 60
acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggccaactcc 120
atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc taccagggta 180
atggggatcc tctagaacta tagctagcat gcctgcaggc tgaccgccca acgacccccg 240
cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 300
acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 360
tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 420
ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat tagtcatcgc 480
tattaccatg gtgatgcggt tttggcagta caccaatggg cgtggatagc ggtttgactc 540
acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa 600
tcaacgggac tttccaaaat gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag 660
gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcactag 720
aagctttatt gcggtagttt atcacagtta aattgctaac gcagtcagtg cttctgacac 780
aacagtctcg aacttaagct gcagaagttg gtcgtgaggc actgggcagg taagtatcaa 840
ggttacaaga caggtttaag gagaccaata gaaactgggc ttgtcgagac agagaagact 900
cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct ttctctccac 960
aggtgtccac tcccagttca attacagctc ttaaggctag agtacttaat acgactcact 1020
ataggctagc ctcgagaatt cacgcgtggt acggtaccat gatggagaca gacacactcc 1080
tgctatgggt actgctgctc tgggttccag gttccactgg tgacgcggcc cagccggcca 1140
ggcgcgcgcg ccgtacgaag cttgactcac cactagaaga cgatgaagtc gggtattcac 1200
accctagata taaagatacc ccgtggtgct cccccatcaa ggtgaagtat ggggatgtgt 1260
actgcagggc ccctcaagga ggatactaca aaacagccct gggaaccagg tgcgacattc 1320
gctgccagaa gggctacgag ctgcatggct cttccctact gatctgccag tcaaacaaac 1380
gatggtctga caaggtcatc tgcaaacaaa agcgatgtcc tacccttgcc atgccagcaa 1440
atggagggtt taagtgtgta gatggtgcct actttaactc ccggtgtgag tattattgtt 1500
caccaggata cacgttgaaa ggggagcgga ccgtcacatg tatggacaac aaggcctgga 1560
gcggccggcc agcctcctgt gtggatatgg aacctcctag aatcaagtgc ccaagtgtga 1620
aggaacgcat tgcagaaccc aacaaactga cagtccgggt gtcctgggag acacccgaag 1680
gaagagacac agcagatgga attcttactg atgtcattct aaaaggcctc cccccaggct 1740
ccaactttcc agaaggagac cacaagatcc agtacacagt ctatgacaga gctgagaata 1800
agggcacttg caaatttcga gttaaagtaa gagtcaaacg ctgtggcaaa ctcaatgccc 1860
cagagaatgg ttacatgaag tgctccagcg acggtgataa ttatggagcc acctgtgagt 1920
tctcctgcat cggcggctat gagctccagg gtagccctgc ccgagtatgt caatccaacc 1980
tggcttggtc tggcacggag cccacctgtg cagccatgaa cgtcaatgtg ggtgtcagaa 2040
cggcagctgc acttctggat cagttttatg agaaaaggag actcctcatt gtgtccacac 2100
ccacagcccg aaacctcctt taccggctcc agctaggaat gctgcagcaa gcacagtgtg 2160
gccttgatct tcgacacatc accgtggtgg agctggtggg tgtgttcccg actctcattg 2220
gcaggatagg agcaaagatt atgcctccag ccctagcgct gcagctcagg ctgttgctgc 2280
gaatcccact ctactccttc agtatggtgc tagtggataa gcatggcatg gacaaagagc 2340
gctatgtctc cctggtgatg cctgtggccc tgttcaacct gattgacact tttcccttga 2400
gaaaagaaga gatggtccta caagccgaaa tgagccagac ctgtaacacc gctcgaggag 2460
ggcccgaaca aaaactcatc tcagaagaga atctgaatag cgccgtcgac catcatcatc 2520
atcatcattg aggtaccctc tagagtcgac ccgggcggcc tcgaggacgg ggtgaactac 2580
gcctgaggat ccgatctttt tccctctgcc aaaaattatg gggacatcat gaagcccctt 2640
gagcatctga cttctggcta ataaaggaaa tttattttca ttgcaatagt gtgttggaat 2700
tttttgtgtc tctcactcgg aagcaattcg ttgatctgaa tttcgaccac ccataatacc 2760
cattaccctg gtagataagt agcatggcgg gttaatcatt aactacaagg aacccctagt 2820
gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa 2880
ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagcct 2940
taattaatta attaaggcct ta                                          2962

<210> 4
<211> 2947
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetically-generated vector

<400> 4
attaggctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg 60
acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggccaactcc 120
atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc taccagggta 180
atggggatcc tctagaacta tagctagcat gcctgcaggc tgaccgccca acgacccccg 240
cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 300
acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 360
tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 420
ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat tagtcatcgc 480
tattaccatg gtgatgcggt tttggcagta caccaatggg cgtggatagc ggtttgactc 540
acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa 600
tcaacgggac tttccaaaat gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag 660
gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcactag 720
aagctttatt gcggtagttt atcacagtta aattgctaac gcagtcagtg cttctgacac 780
aacagtctcg aacttaagct gcagaagttg gtcgtgaggc actgggcagg taagtatcaa 840
ggttacaaga caggtttaag gagaccaata gaaactgggc ttgtcgagac agagaagact 900
cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct ttctctccac 960
aggtgtccac tcccagttca attacagctc ttaaggctag agtacttaat acgactcact 1020
ataggctagc ctcgagaatt cacgcgtggt acggtaccat ggggagcccc gcacatcggc 1080
ccgcgctgct gctgctgctg ccgcctctgc tgctgctgct gctgctgcgc gtcccgccca 1140
gccgcagctt cccaggatcg ggagactcac cactagaaga cgatgaagtc gggtattcac 1200
accctagata taaagatacc ccgtggtgct cccccatcaa ggtgaagtat ggggatgtgt 1260
actgcagggc ccctcaagga ggatactaca aaacagccct gggaaccagg tgcgacattc 1320
gctgccagaa gggctacgag ctgcatggct cttccctact gatctgccag tcaaacaaac 1380
gatggtctga caaggtcatc tgcaaacaaa agcgatgtcc tacccttgcc atgccagcaa 1440
atggagggtt taagtgtgta gatggtgcct actttaactc ccggtgtgag tattattgtt 1500
caccaggata cacgttgaaa ggggagcgga ccgtcacatg tatggacaac aaggcctgga 1560
gcggccggcc agcctcctgt gtggatatgg aacctcctag aatcaagtgc ccaagtgtga 1620
aggaacgcat tgcagaaccc aacaaactga cagtccgggt gtcctgggag acacccgaag 1680
gaagagacac agcagatgga attcttactg atgtcattct aaaaggcctc cccccaggct 1740
ccaactttcc agaaggagac cacaagatcc agtacacagt ctatgacaga gctgagaata 1800
agggcacttg caaatttcga gttaaagtaa gagtcaaacg ctgtggcaaa ctcaatgccc 1860
cagagaatgg ttacatgaag tgctccagcg acggtgataa ttatggagcc acctgtgagt 1920
tctcctgcat cggcggctat gagctccagg gtagccctgc ccgagtatgt caatccaacc 1980
tggcttggtc tggcacggag cccacctgtg cagccatgaa cgtcaatgtg ggtgtcagaa 2040
cggcagctgc acttctggat cagttttatg agaaaaggag actcctcatt gtgtccacac 2100
ccacagcccg aaacctcctt taccggctcc agctaggaat gctgcagcaa gcacagtgtg 2160
gccttgatct tcgacacatc accgtggtgg agctggtggg tgtgttcccg actctcattg 2220
gcaggatagg agcaaagatt atgcctccag ccctagcgct gcagctcagg ctgttgctgc 2280
gaatcccact ctactccttc agtatggtgc tagtggataa gcatggcatg gacaaagagc 2340
gctatgtctc cctggtgatg cctgtggccc tgttcaacct gattgacact tttcccttga 2400
gaaaagaaga gatggtccta caagccgaaa tgagccagac ctgtaacacc gaacaaaaac 2460
tcatctcaga agaggatctg aatagcgccg tcgaccatca tcatcatcat cattgaggta 2520
ccctctagag tcgacccggg cggcctcgag gacggggtga actacgcctg aggatccgat 2580
ctttttccct ctgccaaaaa ttatggggac atcatgaagc cccttgagca tctgacttct 2640
ggctaataaa ggaaatttat tttcattgca atagtgtgtt ggaatttttt gtgtctctca 2700
ctcggaagca attcgttgat ctgaatttcg accacccata atacccatta ccctggtaga 2760
taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac 2820
tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc 2880
gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agccttaatt aattaattaa 2940
ggcctta                                                           2947

<210> 5
<211> 5752
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetically-generated plasmid

<400> 5
attaggctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg 60
acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggccaactcc 120
atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc taccagggta 180
atggggatcc tctagaacta tagctagcat gcctgcaggc tgaccgccca acgacccccg 240
cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 300
acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 360
tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 420
ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat tagtcatcgc 480
tattaccatg gtgatgcggt tttggcagta caccaatggg cgtggatagc ggtttgactc 540
acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa 600
tcaacgggac tttccaaaat gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag 660
gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcactag 720
aagctttatt gcggtagttt atcacagtta aattgctaac gcagtcagtg cttctgacac 780
aacagtctcg aacttaagct gcagaagttg gtcgtgaggc actgggcagg taagtatcaa 840
ggttacaaga caggtttaag gagaccaata gaaactgggc ttgtcgagac agagaagact 900
cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct ttctctccac 960
aggtgtccac tcccagttca attacagctc ttaaggctag agtacttaat acgactcact 1020
ataggctagc ctcgagaatt cacgcgtggt acggtaccat gatggagaca gacacactcc 1080
tgctatgggt actgctgctc tgggttccag gttccactgg tgacgcggcc cagccggcca 1140
ggcgcgcgcg ccgtacgaag cttgactcac cactagaaga cgatgaagtc gggtattcac 1200
accctagata taaagatacc ccgtggtgct cccccatcaa ggtgaagtat ggggatgtgt 1260
actgcagggc ccctcaagga ggatactaca aaacagccct gggaaccagg tgcgacattc 1320
gctgccagaa gggctacgag ctgcatggct cttccctact gatctgccag tcaaacaaac 1380
gatggtctga caaggtcatc tgcaaacaaa agcgatgtcc tacccttgcc atgccagcaa 1440
atggagggtt taagtgtgta gatggtgcct actttaactc ccggtgtgag tattattgtt 1500
caccaggata cacgttgaaa ggggagcgga ccgtcacatg tatggacaac aaggcctgga 1560
gcggccggcc agcctcctgt gtggatatgg aacctcctag aatcaagtgc ccaagtgtga 1620
aggaacgcat tgcagaaccc aacaaactga cagtccgggt gtcctgggag acacccgaag 1680
gaagagacac agcagatgga attcttactg atgtcattct aaaaggcctc cccccaggct 1740
ccaactttcc agaaggagac cacaagatcc agtacacagt ctatgacaga gctgagaata 1800
agggcacttg caaatttcga gttaaagtaa gagtcaaacg ctgtggcaaa ctcaatgccc 1860
cagagaatgg ttacatgaag tgctccagcg acggtgataa ttatggagcc acctgtgagt 1920
tctcctgcat cggcggctat gagctccagg gtagccctgc ccgagtatgt caatccaacc 1980
tggcttggtc tggcacggag cccacctgtg cagccatgaa cgtcaatgtg ggtgtcagaa 2040
cggcagctgc acttctggat cagttttatg agaaaaggag actcctcatt gtgtccacac 2100
ccacagcccg aaacctcctt taccggctcc agctaggaat gctgcagcaa gcacagtgtg 2160
gccttgatct tcgacacatc accgtggtgg agctggtggg tgtgttcccg actctcattg 2220
gcaggatagg agcaaagatt atgcctccag ccctagcgct gcagctcagg ctgttgctgc 2280
gaatcccact ctactccttc agtatggtgc tagtggataa gcatggcatg gacaaagagc 2340
gctatgtctc cctggtgatg cctgtggccc tgttcaacct gattgacact tttcccttga 2400
gaaaagaaga gatggtccta caagccgaaa tgagccagac ctgtaacacc gctcgaggag 2460
ggcccgaaca aaaactcatc tcagaagaga atctgaatag cgccgtcgac catcatcatc 2520
atcatcattg aggtaccctc tagagtcgac ccgggcggcc tcgaggacgg ggtgaactac 2580
gcctgaggat ccgatctttt tccctctgcc aaaaattatg gggacatcat gaagcccctt 2640
gagcatctga cttctggcta ataaaggaaa tttattttca ttgcaatagt gtgttggaat 2700
tttttgtgtc tctcactcgg aagcaattcg ttgatctgaa tttcgaccac ccataatacc 2760
cattaccctg gtagataagt agcatggcgg gttaatcatt aactacaagg aacccctagt 2820
gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa 2880
ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagcct 2940
taattaacct aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt 3000
tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta atagcgaaga 3060
ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat gggacgcgcc 3120
ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact 3180
tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc 3240
cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt 3300
acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg ggccatcgcc 3360
ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt 3420
gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat 3480
tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa 3540
ttttaacaaa atattaacgc ttacaattta ggtggcactt ttcggggaaa tgtgcgcgga 3600
acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa 3660
ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt 3720
gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg 3780
ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg 3840
gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg 3900
agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag 3960
caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca 4020
gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg 4080
agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc 4140
gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg 4200
aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg 4260
ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca attaatagac 4320
tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg 4380
tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg 4440
gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact 4500
atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa 4560
ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca tttttaattt 4620
aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag 4680
ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct 4740
ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt 4800
tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg 4860
cagataccaa atactgttct tctagtgtag ccgtagttag gccaccactt caagaactct 4920
gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc 4980
gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg 5040
tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa 5100
ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg 5160
gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg 5220
ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga 5280
tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt 5340
ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct 5400
gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga 5460
acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat acgcaaaccg 5520
cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt tcccgactgg 5580
aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta ggcaccccag 5640
gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt 5700
cacacaggaa acagctatga ccatgattac gccagattta attaaggcct ta         5752



<210> 6
<211> 5737
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetically-generated plasmid

<400> 6
attaggctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg 60
acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggccaactcc 120
atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc taccagggta 180
atggggatcc tctagaacta tagctagcat gcctgcaggc tgaccgccca acgacccccg 240
cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 300
acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 360
tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 420
ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat tagtcatcgc 480
tattaccatg gtgatgcggt tttggcagta caccaatggg cgtggatagc ggtttgactc 540
acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa 600
tcaacgggac tttccaaaat gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag 660
gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcactag 720
aagctttatt gcggtagttt atcacagtta aattgctaac gcagtcagtg cttctgacac 780
aacagtctcg aacttaagct gcagaagttg gtcgtgaggc actgggcagg taagtatcaa 840
ggttacaaga caggtttaag gagaccaata gaaactgggc ttgtcgagac agagaagact 900
cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct ttctctccac 960
aggtgtccac tcccagttca attacagctc ttaaggctag agtacttaat acgactcact 1020
ataggctagc ctcgagaatt cacgcgtggt acggtaccat ggggagcccc gcacatcggc 1080
ccgcgctgct gctgctgctg ccgcctctgc tgctgctgct gctgctgcgc gtcccgccca 1140
gccgcagctt cccaggatcg ggagactcac cactagaaga cgatgaagtc gggtattcac 1200
accctagata taaagatacc ccgtggtgct cccccatcaa ggtgaagtat ggggatgtgt 1260
actgcagggc ccctcaagga ggatactaca aaacagccct gggaaccagg tgcgacattc 1320
gctgccagaa gggctacgag ctgcatggct cttccctact gatctgccag tcaaacaaac 1380
gatggtctga caaggtcatc tgcaaacaaa agcgatgtcc tacccttgcc atgccagcaa 1440
atggagggtt taagtgtgta gatggtgcct actttaactc ccggtgtgag tattattgtt 1500
caccaggata cacgttgaaa ggggagcgga ccgtcacatg tatggacaac aaggcctgga 1560
gcggccggcc agcctcctgt gtggatatgg aacctcctag aatcaagtgc ccaagtgtga 1620
aggaacgcat tgcagaaccc aacaaactga cagtccgggt gtcctgggag acacccgaag 1680
gaagagacac agcagatgga attcttactg atgtcattct aaaaggcctc cccccaggct 1740
ccaactttcc agaaggagac cacaagatcc agtacacagt ctatgacaga gctgagaata 1800
agggcacttg caaatttcga gttaaagtaa gagtcaaacg ctgtggcaaa ctcaatgccc 1860
cagagaatgg ttacatgaag tgctccagcg acggtgataa ttatggagcc acctgtgagt 1920
tctcctgcat cggcggctat gagctccagg gtagccctgc ccgagtatgt caatccaacc 1980
tggcttggtc tggcacggag cccacctgtg cagccatgaa cgtcaatgtg ggtgtcagaa 2040
cggcagctgc acttctggat cagttttatg agaaaaggag actcctcatt gtgtccacac 2100
ccacagcccg aaacctcctt taccggctcc agctaggaat gctgcagcaa gcacagtgtg 2160
gccttgatct tcgacacatc accgtggtgg agctggtggg tgtgttcccg actctcattg 2220
gcaggatagg agcaaagatt atgcctccag ccctagcgct gcagctcagg ctgttgctgc 2280
gaatcccact ctactccttc agtatggtgc tagtggataa gcatggcatg gacaaagagc 2340
gctatgtctc cctggtgatg cctgtggccc tgttcaacct gattgacact tttcccttga 2400
gaaaagaaga gatggtccta caagccgaaa tgagccagac ctgtaacacc gaacaaaaac 2460
tcatctcaga agaggatctg aatagcgccg tcgaccatca tcatcatcat cattgaggta 2520
ccctctagag tcgacccggg cggcctcgag gacggggtga actacgcctg aggatccgat 2580
ctttttccct ctgccaaaaa ttatggggac atcatgaagc cccttgagca tctgacttct 2640
ggctaataaa ggaaatttat tttcattgca atagtgtgtt ggaatttttt gtgtctctca 2700
ctcggaagca attcgttgat ctgaatttcg accacccata atacccatta ccctggtaga 2760
taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac 2820
tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc 2880
gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agccttaatt aacctaattc 2940
actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc aacttaatcg 3000
ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc gcaccgatcg 3060
cccttcccaa cagttgcgca gcctgaatgg cgaatgggac gcgccctgta gcggcgcatt 3120
aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc 3180
gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca 3240
agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc 3300
caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt 3360
tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac 3420
aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc 3480
ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt 3540
aacgcttaca atttaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta 3600
tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt 3660
caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc 3720
ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa 3780
gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt 3840
aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt 3900
ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc 3960
atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg 4020
gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg 4080
gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac 4140
atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca 4200
aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta 4260
actggcgaac tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat 4320
aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa 4380
tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag 4440
ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat 4500
agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt 4560
tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg 4620
aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga 4680
gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta 4740
atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa 4800
gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact 4860
gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca 4920
tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt 4980
accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg 5040
ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag 5100
cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta 5160
agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat 5220
ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg 5280
tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc 5340
ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac 5400
cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc 5460
gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt 5520
tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc gggcagtgag 5580
cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg 5640
cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac aggaaacagc 5700
tatgaccatg attacgccag atttaattaa ggcctta                          5737



<210> 7
<211> 405
<212> PRT
<213> Homo sapien

<400> 7
Met Gly Ser Pro Ala His Arg Pro Ala Leu Leu Leu Leu Leu Pro Pro
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Leu Arg Val Pro Pro Ser Arg Ser Phe Pro
            20                  25                  30          
Gly Ser Gly Asp Ser Pro Leu Glu Asp Asp Glu Val Gly Tyr Ser His
        35                  40                  45              
Pro Arg Tyr Lys Asp Thr Pro Trp Cys Ser Pro Ile Lys Val Lys Tyr
    50                  55                  60                  
Gly Asp Val Tyr Cys Arg Ala Pro Gln Gly Gly Tyr Tyr Lys Thr Ala
65                  70                  75                  80  
Leu Gly Thr Arg Cys Asp Ile Arg Cys Gln Lys Gly Tyr Glu Leu His
                85                  90                  95      
Gly Ser Ser Leu Leu Ile Cys Gln Ser Asn Lys Arg Trp Ser Asp Lys
            100                 105                 110         
Val Ile Cys Lys His Met Glu Pro Pro Arg Ile Lys Cys Pro Ser Val
        115                 120                 125             
Lys Glu Arg Ile Ala Glu Pro Asn Lys Leu Thr Val Arg Val Ser Trp
    130                 135                 140                 
Glu Thr Pro Glu Gly Arg Asp Thr Ala Asp Gly Ile Leu Thr Asp Val
145                 150                 155                 160 
Ile Leu Lys Gly Leu Pro Pro Gly Ser Asn Phe Pro Glu Gly Asp His
                165                 170                 175     
Lys Ile Gln Tyr Thr Val Tyr Asp Arg Ala Glu Asn Lys Gly Thr Cys
            180                 185                 190         
Lys Phe Arg Val Lys Val Arg Val Lys Arg Cys Gly Lys Leu Asn Ala
        195                 200                 205             
Pro Glu Asn Gly Tyr Met Lys Cys Ser Ser Asp Gly Asp Asn Tyr Gly
    210                 215                 220                 
Ala Thr Cys Glu Phe Ser Cys Ile Gly Gly Tyr Glu Leu Gln Gly Ser
225                 230                 235                 240 
Pro Ala Arg Val Cys Gln Ser Asn Leu Ala Trp Ser Gly Thr Glu Pro
                245                 250                 255     
Thr Cys Ala Ala Met Asn Val Asn Val Gly Val Arg Thr Ala Ala Ala
            260                 265                 270         
Leu Leu Asp Gln Phe Tyr Glu Lys Arg Arg Leu Leu Ile Val Ser Thr
        275                 280                 285             
Pro Thr Ala Arg Asn Leu Leu Tyr Arg Leu Gln Leu Gly Met Leu Gln
    290                 295                 300                 
Gln Ala Gln Cys Gly Leu Asp Leu Arg His Ile Thr Val Val Glu Leu
305                 310                 315                 320 
Val Gly Val Phe Pro Thr Leu Ile Gly Arg Ile Gly Ala Lys Ile Met
                325                 330                 335     
Pro Pro Ala Leu Ala Leu Gln Leu Arg Leu Leu Leu Arg Ile Pro Leu
            340                 345                 350         
Tyr Ser Phe Ser Met Val Leu Val Asp Lys His Gly Met Asp Lys Glu
        355                 360                 365             
Arg Tyr Val Ser Leu Val Met Pro Val Ala Leu Phe Asn Leu Ile Asp
    370                 375                 380                 
Thr Phe Pro Leu Arg Lys Glu Glu Met Val Leu Gln Ala Glu Met Ser
385                 390                 395                 400 
Gln Thr Cys Asn Thr
                405 


<210> 8
<211> 379
<212> PRT
<213> Homo sapien

<400> 8
Met Gly Ser Pro Ala His Arg Pro Ala Leu Leu Leu Leu Leu Pro Pro
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Leu Arg Val Pro Pro Ser Arg Ser Phe Pro
            20                  25                  30          
Gly Ser Gly Asp Ser Pro Leu Glu Asp Asp Glu Val Gly Tyr Ser His
        35                  40                  45              
Pro Arg Tyr Lys Asp Thr Pro Trp Cys Ser Pro Ile Lys Val Lys Tyr
    50                  55                  60                  
Gly Asp Val Tyr Cys Arg Ala Pro Gln Gly Gly Tyr Tyr Lys Thr Ala
65                  70                  75                  80  
Leu Gly Thr Arg Cys Asp Ile Arg Cys Gln Lys Gly Tyr Glu Leu His
                85                  90                  95      
Gly Ser Ser Leu Leu Ile Cys Gln Ser Asn Lys Arg Trp Ser Asp Lys
            100                 105                 110         
Val Ile Cys Lys Gln Lys Arg Cys Pro Thr Leu Ala Met Pro Ala Asn
        115                 120                 125             
Gly Gly Phe Lys Cys Val Asp Gly Ala Tyr Phe Asn Ser Arg Cys Glu
    130                 135                 140                 
Tyr Tyr Cys Ser Pro Gly Tyr Thr Leu Lys Gly Glu Arg Thr Val Thr
145                 150                 155                 160 
Cys Met Asp Asn Lys Ala Trp Ser Gly Arg Pro Ala Ser Cys Val Asp
                165                 170                 175     
Met Glu Pro Pro Arg Ile Lys Cys Pro Ser Val Lys Glu Arg Ile Ala
            180                 185                 190         
Glu Pro Asn Lys Leu Thr Val Arg Val Ser Trp Glu Thr Pro Glu Gly
        195                 200                 205             
Arg Asp Thr Ala Asp Gly Ile Leu Thr Asp Val Ile Leu Lys Gly Leu
    210                 215                 220                 
Pro Pro Gly Ser Asn Phe Pro Glu Gly Asp His Lys Ile Gln Tyr Thr
225                 230                 235                 240 
Val Tyr Asp Arg Ala Glu Asn Lys Gly Thr Cys Lys Phe Arg Val Lys
                245                 250                 255     
Val Arg Val Lys Arg Cys Gly Lys Leu Asn Ala Pro Glu Asn Gly Tyr
            260                 265                 270         
Met Lys Cys Ser Ser Asp Gly Asp Asn Tyr Gly Ala Thr Cys Glu Phe
        275                 280                 285             
Ser Cys Ile Gly Gly Tyr Glu Leu Gln Gly Ser Pro Ala Arg Val Cys
    290                 295                 300                 
Gln Ser Asn Leu Ala Trp Ser Gly Thr Glu Pro Thr Cys Ala Ala Met
305                 310                 315                 320 
Asn Val Asn Val Gly Val Arg Thr Ala Ala Ala Leu Leu Asp Gln Phe
                325                 330                 335     
Tyr Glu Lys Arg Arg Leu Leu Ile Val Ser Thr Pro Thr Ala Arg Asn
            340                 345                 350         
Leu Leu Tyr Arg Leu Gln Leu Gly Met Leu Gln Ala Val Ala Ala Asn
        355                 360                 365             
Pro Thr Leu Leu Leu Gln Tyr Gly Ala Ser Gly
    370                 375                 

