                         SEQUENCE LISTING

<110>  TRANSGENE S.A.
       FOURNILLIER, Anne
       INCHAUSPE, Genevieve

<120>  immunotherapy composition and regimen for treating hepatitis C 
       virus infection

<130>  361598D31569

<150>  EP 11306249.1
<151>  2011-09-29

<150>  EP 11306434.9
<151>  2011-11-04

<150>  EP 11306442.2
<151>  2011-11-07

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  947
<212>  PRT
<213>  Hepatitis C virus

<400>  1

Met Ala Pro Ile Thr Ala Tyr Ser Gln Gln Thr Arg Gly Leu Leu Gly 
1               5                   10                  15      


Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Asp Gly 
            20                  25                  30          


Glu Val Gln Val Leu Ser Thr Ala Thr Gln Ser Phe Leu Ala Thr Cys 
        35                  40                  45              


Val Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Ser Lys Thr 
    50                  55                  60                  


Leu Ala Gly Pro Lys Gly Pro Ile Thr Gln Met Tyr Thr Asn Val Asp 
65                  70                  75                  80  


Gln Asp Leu Val Gly Trp Pro Ala Pro Pro Gly Ala Arg Ser Met Thr 
                85                  90                  95      


Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala 
            100                 105                 110         


Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu 
        115                 120                 125             


Ser Pro Arg Pro Val Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu 
    130                 135                 140                 


Leu Cys Pro Ser Gly His Val Val Gly Ile Phe Arg Ala Ala Val Cys 
145                 150                 155                 160 


Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Met 
                165                 170                 175     


Glu Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro 
            180                 185                 190         


Ala Val Pro Gln Thr Phe Gln Val Ala His Leu His Ala Pro Thr Gly 
        195                 200                 205             


Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr 
    210                 215                 220                 


Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly 
225                 230                 235                 240 


Ala Tyr Met Ser Lys Ala His Gly Ile Glu Pro Asn Ile Arg Thr Gly 
                245                 250                 255     


Val Arg Thr Ile Thr Thr Gly Gly Pro Ile Thr Tyr Ser Thr Tyr Gly 
            260                 265                 270         


Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile 
        275                 280                 285             


Ile Cys Asp Glu Cys His Ser Thr Asp Trp Thr Thr Ile Leu Gly Ile 
    290                 295                 300                 


Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val 
305                 310                 315                 320 


Leu Ala Thr Ala Thr Pro Pro Gly Ser Ile Thr Val Pro His Pro Asn 
                325                 330                 335     


Ile Glu Glu Val Ala Leu Ser Asn Thr Gly Glu Ile Pro Phe Tyr Gly 
            340                 345                 350         


Lys Ala Ile Pro Ile Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe 
        355                 360                 365             


Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Thr Gly 
    370                 375                 380                 


Leu Gly Leu Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val 
385                 390                 395                 400 


Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met 
                405                 410                 415     


Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys 
            420                 425                 430         


Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu 
        435                 440                 445             


Thr Thr Thr Val Pro Gln Asp Ala Val Ser Arg Ser Gln Arg Arg Gly 
    450                 455                 460                 


Arg Thr Gly Arg Gly Arg Ser Gly Ile Tyr Arg Phe Val Thr Pro Gly 
465                 470                 475                 480 


Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr 
                485                 490                 495     


Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val 
            500                 505                 510         


Arg Leu Arg Ala Tyr Leu Asn Thr Pro Gly Leu Pro Val Cys Gln Asp 
        515                 520                 525             


His Leu Glu Phe Trp Glu Ser Val Phe Thr Gly Leu Thr His Ile Asp 
    530                 535                 540                 


Ala His Phe Leu Ser Gln Thr Lys Gln Ala Gly Asp Asn Phe Pro Tyr 
545                 550                 555                 560 


Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro 
                565                 570                 575     


Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr 
            580                 585                 590         


Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn 
        595                 600                 605             


Glu Ile Thr Leu Thr His Pro Ile Thr Lys Phe Val Met Ala Cys Met 
    610                 615                 620                 


Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly 
625                 630                 635                 640 


Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Thr Thr Gly Ser Val Val 
                645                 650                 655     


Ile Val Gly Arg Ile Ile Leu Ser Gly Arg Pro Ala Val Val Pro Asp 
            660                 665                 670         


Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Ala Ser 
        675                 680                 685             


His Leu Pro Tyr Ile Glu Gln Gly Met Gln Leu Ala Glu Gln Phe Lys 
    690                 695                 700                 


Gln Lys Ala Leu Gly Leu Leu Gln Thr Ala Thr Lys Gln Ala Glu Ala 
705                 710                 715                 720 


Ala Ala Pro Val Val Glu Ser Arg Trp Arg Ala Leu Glu Ala Phe Trp 
                725                 730                 735     


Ala Lys His Met Trp Asn Phe Ile Ser Gly Ile Gln Tyr Leu Ala Gly 
            740                 745                 750         


Leu Ser Thr Leu Pro Gly Asn Pro Ala Ile Ala Ser Leu Met Ala Phe 
        755                 760                 765             


Thr Ala Ser Ile Thr Ser Pro Leu Thr Thr Gln Asn Thr Leu Leu Phe 
    770                 775                 780                 


Asn Ile Leu Gly Gly Trp Val Ala Ala Gln Leu Ala Pro Pro Ser Ala 
785                 790                 795                 800 


Ala Ser Ala Phe Val Gly Ala Gly Ile Ala Gly Ala Ala Ile Gly Ser 
                805                 810                 815     


Ile Gly Leu Gly Lys Val Leu Val Asp Ile Leu Ala Gly Tyr Gly Ala 
            820                 825                 830         


Gly Val Ala Gly Ala Leu Val Ala Phe Lys Val Met Ser Gly Glu Ala 
        835                 840                 845             


Pro Ser Ala Glu Asp Leu Val Asn Leu Leu Pro Ala Ile Leu Ser Pro 
    850                 855                 860                 


Gly Ala Leu Val Val Gly Ile Val Cys Ala Ala Ile Leu Arg Arg His 
865                 870                 875                 880 


Val Gly Pro Gly Glu Gly Ala Val Gln Trp Met Asn Arg Leu Ile Ala 
                885                 890                 895     


Phe Ala Ser Arg Gly Asn His Val Ser Pro Thr His Tyr Val Pro Glu 
            900                 905                 910         


Ser Asp Ala Ala Ala Arg Val Thr Gln Ile Leu Ser Ser Leu Thr Ile 
        915                 920                 925             


Thr Gln Leu Leu Lys Arg Leu His Gln Trp Ile Asn Glu Asp Cys Ser 
    930                 935                 940                 


Thr Pro Cys 
945         


<210>  2
<211>  592
<212>  PRT
<213>  Hepatitis C virus

<400>  2

Met Ser Met Ser Tyr Thr Trp Thr Gly Ala Leu Ile Thr Pro Cys Ala 
1               5                   10                  15      


Ala Glu Glu Ser Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser Leu Leu 
            20                  25                  30          


Arg His His Ser Met Val Tyr Ser Thr Thr Ser Arg Ser Ala Ser Leu 
        35                  40                  45              


Arg Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Leu Asp Asp His 
    50                  55                  60                  


Tyr Arg Asp Val Leu Lys Glu Met Lys Ala Lys Ala Ser Thr Val Lys 
65                  70                  75                  80  


Ala Arg Leu Leu Ser Ile Glu Glu Ala Cys Lys Leu Thr Pro Pro His 
                85                  90                  95      


Ser Ala Lys Ser Lys Phe Gly Tyr Gly Ala Lys Asp Val Arg Ser Leu 
            100                 105                 110         


Ser Ser Arg Ala Val Asn His Ile Arg Ser Val Trp Glu Asp Leu Leu 
        115                 120                 125             


Glu Asp Thr Glu Thr Pro Ile Asp Thr Thr Ile Met Ala Lys Asn Glu 
    130                 135                 140                 


Val Phe Cys Val Gln Pro Glu Lys Gly Gly Arg Lys Pro Ala Arg Leu 
145                 150                 155                 160 


Ile Val Phe Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met Ala Leu 
                165                 170                 175     


Tyr Asp Val Val Ser Thr Leu Pro Gln Ala Val Met Gly Pro Ser Tyr 
            180                 185                 190         


Gly Phe Gln Tyr Ser Pro Gly Gln Arg Val Glu Phe Leu Val Asn Thr 
        195                 200                 205             


Trp Lys Ser Lys Lys Cys Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys 
    210                 215                 220                 


Phe Asp Ser Thr Val Thr Glu Asn Asp Ile Arg Thr Glu Glu Ser Ile 
225                 230                 235                 240 


Tyr Gln Cys Cys Asp Leu Ala Pro Glu Ala Arg Gln Ala Ile Lys Ser 
                245                 250                 255     


Leu Thr Glu Arg Leu Tyr Ile Gly Gly Pro Leu Thr Asn Ser Lys Gly 
            260                 265                 270         


Gln Asn Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr 
        275                 280                 285             


Ser Cys Gly Asn Thr Leu Thr Cys Tyr Leu Lys Ala Thr Ala Ala Cys 
    290                 295                 300                 


Arg Ala Ala Lys Leu Gln Asp Cys Thr Met Leu Val Asn Gly Asp Asp 
305                 310                 315                 320 


Leu Val Val Ile Cys Glu Ser Ala Gly Thr Gln Glu Asp Ala Ala Ser 
                325                 330                 335     


Leu Arg Val Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly 
            340                 345                 350         


Asp Pro Pro Gln Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser 
        355                 360                 365             


Ser Asn Val Ser Val Ala His Asp Ala Ser Gly Lys Arg Val Tyr Tyr 
    370                 375                 380                 


Leu Thr Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr 
385                 390                 395                 400 


Val Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Met Tyr 
                405                 410                 415     


Ala Pro Thr Leu Trp Ala Arg Met Ile Leu Met Thr His Phe Phe Ser 
            420                 425                 430         


Ile Leu Leu Ala Gln Glu Gln Leu Glu Lys Ala Leu Asp Cys Gln Ile 
        435                 440                 445             


Tyr Gly Ala Cys Tyr Ser Ile Glu Pro Leu Asp Leu Pro Gln Ile Ile 
    450                 455                 460                 


Glu Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Ser Tyr Ser Pro 
465                 470                 475                 480 


Gly Glu Ile Asn Arg Val Ala Ser Cys Leu Arg Lys Leu Gly Val Pro 
                485                 490                 495     


Pro Leu Arg Val Trp Arg His Arg Ala Arg Ser Val Arg Ala Lys Leu 
            500                 505                 510         


Leu Ser Gln Gly Gly Arg Ala Ala Thr Cys Gly Lys Tyr Leu Phe Asn 
        515                 520                 525             


Trp Ala Val Arg Thr Lys Leu Lys Leu Thr Pro Ile Pro Ala Ala Ser 
    530                 535                 540                 


Gln Leu Asp Leu Ser Gly Trp Phe Val Ala Gly Tyr Asn Gly Gly Asp 
545                 550                 555                 560 


Ile Tyr His Ser Leu Ser Arg Ala Arg Pro Arg Trp Phe Met Leu Cys 
                565                 570                 575     


Leu Leu Leu Leu Ser Val Gly Val Gly Ile Tyr Leu Leu Pro Asn Arg 
            580                 585                 590         


<210>  3
<211>  2844
<212>  DNA
<213>  Hepatitis C virus

<400>  3
atggcgccta tcacggccta ttcccaacaa acgcggggcc tgcttggctg tatcatcact       60

agcctcacag gtcgggacaa gaaccaggtc gatggggagg ttcaggtgct ctccaccgca      120

acgcaatctt tcctggcgac ctgcgtcaat ggcgtgtgtt ggaccgtcta ccatggtgcc      180

ggctcgaaga ccctggccgg cccgaagggt ccaatcaccc aaatgtacac caatgtagac      240

caggacctcg tcggctggcc ggcgcccccc ggggcgcgct ccatgacacc gtgcacctgc      300

ggcagctcgg acctttactt ggtcacgagg catgccgatg tcattccggt gcgccggcga      360

ggcgacagca gggggagtct actctcccct aggcccgtct cctacctgaa gggctcctcg      420

ggtggaccac tgctttgccc ttcggggcac gttgtaggca tcttccgggc tgctgtgtgc      480

acccgggggg ttgcgaaggc ggtggacttc atacccgttg agtctatgga aactaccatg      540

cggtctccgg tcttcacaga caactcatcc cctccggccg taccgcaaac attccaagtg      600

gcacatttac acgctcccac tggcagcggc aagagcacca aagtgccggc tgcatatgca      660

gcccaagggt acaaggtgct cgtcctaaac ccgtccgttg ctgccacatt gggctttgga      720

gcgtatatgt ccaaggcaca tggcatcgag cctaacatca gaactggggt aaggaccatc      780

accacgggcg gccccatcac gtactccacc tatggcaagt tccttgccga cggtggatgc      840

tccgggggcg cctatgacat cataatatgt gacgaatgcc actcaactga ctggacaacc      900

atcttgggca tcggcacagt cctggatcag gcagagacgg ctggagcgcg gctcgtcgtg      960

ctcgccaccg ccacgcctcc gggatcgatc accgtgccac accccaacat cgaggaagtg     1020

gccctgtcca acactgggga gattcccttc tatggcaaag ccatccccat tgaggccatc     1080

aaggggggaa ggcatctcat cttctgccat tccaagaaga agtgtgacga gctcgccgca     1140

aagctgacag gcctcggact caatgctgta gcgtattacc ggggtctcga tgtgtccgtc     1200

ataccgacta gcggagacgt cgttgtcgtg gcaacagacg ctctaatgac gggctttacc     1260

ggcgactttg actcagtgat cgactgcaac acatgtgtca cccagacagt cgatttcagc     1320

ttggatccca ccttcaccat tgagacgaca accgtgcccc aagacgcggt gtcgcgctcg     1380

cagcggcgag gtaggactgg caggggcagg agtggcatct acaggtttgt gactccagga     1440

gaacggccct caggcatgtt cgactcctcg gtcctgtgtg agtgctatga cgcaggctgc     1500

gcttggtatg agctcacgcc cgctgagact acagtcaggt tgcgggctta cctgaataca     1560

ccagggttgc ccgtctgcca ggaccatctg gagttctggg aaagcgtctt cacaggcctc     1620

acccacatag atgcccactt cctgtcccaa accaagcagg caggagacaa cttcccctac     1680

ctggtggcat accaagccac ggtgtgcgcc agggctcagg ctccacctcc atcgtgggat     1740

caaatgtgga agtgtctcat acggcttaaa cctacgctgc acgggccaac acccctgctg     1800

tataggctag gagccgttca aaatgagatc accctcacac atcccataac caaattcgtc     1860

atggcatgca tgtcggccga cctggaggtc gtcactagca cctgggtgct ggtaggcgga     1920

gtccttgcag ctctggccgc atattgcctg acaaccggta gtgtggtcat tgtgggtagg     1980

atcattttgt ccgggaggcc ggctgttgtt cccgacaggg aagtcctcta ccgggagttc     2040

gatgaaatgg aagagtgcgc ctcacacctc ccttacatcg agcaaggaat gcagctcgcc     2100

gagcagttca agcagaaggc actcgggttg ctgcaaacag ccaccaagca agcggaggcc     2160

gctgctcccg tggtggagtc caggtggcgg gcccttgagg ccttctgggc aaagcacatg     2220

tggaacttca tcagcgggat acagtactta gcaggcttat ccactctgcc tgggaacccc     2280

gcgatagcat cactgatggc attcacagcc tctatcacca gtccgctcac cacccagaat     2340

accctcctat tcaacatctt agggggatgg gtggctgctc aactcgctcc tcccagtgct     2400

gcttcggcct tcgtgggtgc cggcattgcc ggtgcggcca ttggcagcat aggccttggg     2460

aaggtgcttg tggacattct ggcgggctat ggagcggggg tggccggtgc actcgtggct     2520

tttaaggtca tgagcggcga ggcgccctcc gccgaggacc tggttaactt gctccctgcc     2580

atcctctccc ccggcgcctt ggtcgtcggg atcgtgtgtg cagcaatcct gcgtcggcac     2640

gtgggcccgg gagagggggc tgtgcagtgg atgaaccggc tgatagcgtt cgcttcgcgg     2700

ggtaaccacg tttcccccac gcactacgtg cctgagagcg acgccgcagc acgtgtaact     2760

cagatcctct ccagcctcac catcactcag ctgctgaaga ggcttcacca gtggattaat     2820

gaggactgct ccacgccatg ctaa                                            2844


<210>  4
<211>  1779
<212>  DNA
<213>  Hepatitis C virus

<400>  4
atgtcaatgt cctacacatg gacaggtgcc ttgatcacgc catgcgctgc ggaggagagc       60

aagttgccca tcaatccgtt gagcaactct ttgctgcgtc accacagtat ggtctactcc      120

acaacatctc gcagcgcaag tctgcggcag aagaaggtca cctttgacag actgcaagtc      180

ctggacgacc actaccggga cgtgctcaag gagatgaagg cgaaggcgtc cacagttaag      240

gctaggcttc tatctataga ggaggcctgc aaactgacgc ccccacattc ggccaaatcc      300

aaatttggct acggggcgaa ggacgtccgg agcctatcca gcagggccgt caaccacatc      360

cgctccgtgt gggaggactt gctggaagac actgaaacac caattgatac caccatcatg      420

gcaaaaaatg aggttttctg cgtccaacca gagaaaggag gccgcaagcc agctcgcctt      480

atcgtattcc cagacctggg ggtacgtgta tgcgagaaga tggcccttta cgacgtggtc      540

tccacccttc ctcaggccgt gatgggcccc tcatacggat tccagtactc tcctgggcag      600

cgggtcgagt tcctggtgaa tacctggaaa tcaaagaaat gccctatggg cttctcatat      660

gacacccgct gctttgactc aacggtcact gagaatgaca tccgtactga ggagtcaatc      720

taccaatgtt gtgacttggc ccccgaagcc agacaggcca taaagtcgct cacagagcgg      780

ctctacatcg ggggtcccct gactaattca aaagggcaga actgcggtta tcgccggtgc      840

cgcgcgagcg gcgtgctgac gactagctgc ggcaataccc tcacatgcta cttgaaagcc      900

actgcggcct gtcgagctgc aaagctccag gactgcacga tgctcgtgaa cggagacgac      960

cttgtcgtta tctgcgaaag cgcgggaacc caggaggatg cggcgagcct acgagtcttc     1020

acggaggcta tgactaggta ctctgccccc cccggggacc cgccccaacc agaatacgac     1080

ttggagctga taacgtcatg ctcctccaat gtgtcggtcg cgcacgatgc atccggcaaa     1140

agggtgtact acctcacccg tgaccccacc acccccctcg cacgggctgc gtgggagaca     1200

gttagacaca ctccagtcaa ctcctggcta ggcaatatca tcatgtatgc gcccacccta     1260

tgggcgagga tgattctgat gactcatttc ttctctatcc ttctagctca ggagcaactt     1320

gaaaaagccc tggattgtca gatctacggg gcctgctact ccattgagcc acttgaccta     1380

cctcagatca tcgaacgact ccatggtctt agcgcatttt cactccatag ttactctcca     1440

ggtgagatca atagggtggc ttcatgcctc aggaaacttg gggtaccacc cttgcgagtc     1500

tggagacatc gggccagaag tgtccgcgct aagttgctgt cccagggggg gagggccgcc     1560

acttgcggca aatacctctt caactgggca gtaaggacca agcttaaact cactccaatc     1620

ccggctgcgt cccagctaga cttgtccggc tggttcgttg ctggttacaa cgggggagac     1680

atatatcaca gcctgtctcg tgcccgaccc cgttggttca tgttgtgcct actcctactt     1740

tctgtagggg taggcatcta cctgctcccc aaccggtaa                            1779


